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Review Article

Fc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeutics

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Pages 235-254 | Received 14 Mar 2013, Accepted 26 Jun 2013, Published online: 24 Oct 2013

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Crossref
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Crossref
A. R. Satvik Iyengar, Shreya Gupta, Snehal Jawalekar & Abhay H. Pande. (2019) Protein Chimerization: A New Frontier for Engineering Protein Therapeutics with Improved Pharmacokinetics. Journal of Pharmacology and Experimental Therapeutics 370:3, pages 703-714.
Crossref
R. S. Pearsall, M. V. Davies, M. Cannell, J. Li, J. Widrick, A. W. Mulivor, S. Wallner, M. E. Troy, M. Spaits, K. Liharska, D. Sako, R. Castonguay, S. Keates, A. V. Grinberg, R. N. V. S. Suragani & R. Kumar. (2019) Follistatin-based ligand trap ACE-083 induces localized hypertrophy of skeletal muscle with functional improvement in models of neuromuscular disease. Scientific Reports 9:1.
Crossref
H. A. Daniel Lagassé, Hartmut Hengel, Basil Golding & Zuben E. Sauna. (2019) Fc-Fusion Drugs Have FcγR/C1q Binding and Signaling Properties That May Affect Their Immunogenicity. The AAPS Journal 21:4.
Crossref
R.R.C. New, B.D. Moore, W. Butcher, R. Mahood, M.S. Lever, S. Smither, L. O'Brien, S.A. Weller, M. Bayliss, L.C.D. Gibson, C. Macleod, M. Bogus, R. Harvey, N. Almond & E.D. Williamson. (2019) Antibody-mediated protection against MERS-CoV in the murine model. Vaccine 37:30, pages 4094-4102.
Crossref
Alexandra Schifferli, Falk Nimmerjahn & Thomas Kühne. (2019) Immunomodulation in Primary Immune Thrombocytopenia: A Possible Role of the Fc Fragment of Romiplostim?. Frontiers in Immunology 10.
Crossref
Gang Niu, Guohao Wang, Joseph Lau, Lixin Lang, Orit Jacobson, Ying Ma, Dale O. Kiesewetter, Shaoliang Zhang & Xiaoyuan Chen. (2018) Antidiabetic Effect of Abextide, a Long‐Acting Exendin‐4 Analogue in Cynomolgus Monkeys. Advanced Healthcare Materials 8:12, pages 1800686.
Crossref
Rahela Zaman, Rowshan Ara Islam, Nabilah Ibnat, Iekhsan Othman, Anuar Zaini, Chooi Yeng Lee & Ezharul Hoque Chowdhury. (2019) Current strategies in extending half-lives of therapeutic proteins. Journal of Controlled Release 301, pages 176-189.
Crossref
Nina Hanke, Claudia Kunz, Meinolf Thiemann, Harald Fricke & Thorsten Lehr. (2019) Translational PBPK Modeling of the Protein Therapeutic and CD95L Inhibitor Asunercept to Develop Dose Recommendations for Its First Use in Pediatric Glioblastoma Patients. Pharmaceutics 11:4, pages 152.
Crossref
Roselyne Castonguay, Jennifer Lachey, Samantha Wallner, Jamie Strand, Katia Liharska, Abigail E. Watanabe, Marishka Cannell, Monique V. Davies, Dianne Sako, Megan E. Troy, Lavanya Krishnan, Aaron W. Mulivor, Huiming Li, Sarah Keates, Mark J. Alexander, R. Scott Pearsall & Ravi Kumar. (2019) Follistatin-288-Fc Fusion Protein Promotes Localized Growth of Skeletal Muscle. Journal of Pharmacology and Experimental Therapeutics 368:3, pages 435-445.
Crossref
Safieh Aghaabdollahian, Reza Ahangari Cohan, Dariush Norouzian, Fatemeh Davami, Mohammad Reza Asadi Karam, Fatemeh Torkashvand, Golnaz Vaseghi, Reza Moazzami & Sakineh Latif Dizaji. (2019) Enhancing bioactivity, physicochemical, and pharmacokinetic properties of a nano-sized, anti-VEGFR2 Adnectin, through PASylation technology. Scientific Reports 9:1.
Crossref
Atefeh Ghorbani Aghdam, Saeed Moradhaseli, Farnoush Jafari, Paria Motahari, Sepideh Samavat, Rasoul Mahboudi & Shayan Maleknia. (2019) Therapeutic Fc fusion protein misfolding: A three-phasic cultivation experimental design. PLOS ONE 14:1, pages e0210712.
Crossref
Valentina Lorenzoni, Isotta Triulzi & Giuseppe Turchetti. (2018) Budget impact analysis of the use of extended half-life recombinant factor VIII (efmoroctocog alfa) for the treatment of congenital haemophilia a: the Italian National Health System perspective. BMC Health Services Research 18:1.
Crossref
Xutong Shen, Qingqing Li, Fanwen Wang, Jingxiao Bao, Mengting Dai, Heng Zheng & Xingzhen Lao. (2018) Generation of a novel long-acting thymosin alpha1-Fc fusion protein and its efficacy for the inhibition of breast cancer in vivo. Biomedicine & Pharmacotherapy 108, pages 610-617.
Crossref
Saori Suzuki, Hiroaki Annaka, Shota Konno, Izumi Kumagai & Ryutaro Asano. (2018) Engineering the hinge region of human IgG1 Fc-fused bispecific antibodies to improve fragmentation resistance. Scientific Reports 8:1.
Crossref
Jisoo Park, Yumi Lee, Byoung Joon Ko & Tae Hyeon Yoo. (2018) Peptide-Directed Photo-Cross-Linking for Site-Specific Conjugation of IgG. Bioconjugate Chemistry 29:10, pages 3240-3244.
Crossref
Fanwen Wang, Tingting Yu, Heng Zheng & Xingzhen Lao. (2018) Thymosin Alpha1-Fc Modulates the Immune System and Down-regulates the Progression of Melanoma and Breast Cancer with a Prolonged Half-life. Scientific Reports 8:1.
Crossref
Rob Peters & Tim Harris. (2018) Advances and innovations in haemophilia treatment. Nature Reviews Drug Discovery 17:7, pages 493-508.
Crossref
Pan Liu, Jan Wysocki, Tomokazu Souma, Minghao Ye, Veronica Ramirez, Bisheng Zhou, Lisa D. Wilsbacher, Susan E. Quaggin, Daniel Batlle & Jing Jin. (2018) Novel ACE2-Fc chimeric fusion provides long-lasting hypertension control and organ protection in mouse models of systemic renin angiotensin system activation. Kidney International 94:1, pages 114-125.
Crossref
Tae Yoon Kim, Hyo-Deok Seo, Joong-jae Lee, Jung Ae Kang, Woo Sik Kim, Hye-Min Kim, Ha-Yeon Song, Ji Min Park, Dong-Eun Lee & Hak-Sung Kim. (2018) A dimeric form of a small-sized protein binder exhibits enhanced anti-tumor activity through prolonged blood circulation. Journal of Controlled Release 279, pages 282-291.
Crossref
Richard S. Blumberg & David Lillicrap. (2018) Tolerogenic properties of the Fc portion of IgG and its relevance to the treatment and management of hemophilia. Blood 131:20, pages 2205-2214.
Crossref
Dongfen Yuan, Frederik Rode & Yanguang Cao. (2018) A Minimal Physiologically Based Pharmacokinetic Model with a Nested Endosome Compartment for Novel Engineered Antibodies. The AAPS Journal 20:3.
Crossref
J. Mahlangu, G. Young, C. Hermans, V. Blanchette, E. Berntorp & E. Santagostino. (2018) Defining extended half-life rFVIII-A critical review of the evidence. Haemophilia 24:3, pages 348-358.
Crossref
Minzhi Yu, Mason M. Benjamin, Santhanakrishnan Srinivasan, Emily E. Morin, Ekaterina I. Shishatskaya, Steven P. Schwendeman & Anna Schwendeman. (2018) Battle of GLP-1 delivery technologies. Advanced Drug Delivery Reviews 130, pages 113-130.
Crossref
Diogo M. Magnani, Thomas F. Rogers, Nicholas J. Maness, Nathan D. Grubaugh, Nathan Beutler, Varian K. Bailey, Lucas Gonzalez-Nieto, Martin J. Gutman, Núria Pedreño-Lopez, Jaclyn M. Kwal, Michael J. Ricciardi, Tereance A. Myers, Justin G. Julander, Rudolf P. Bohm, Margaret H. Gilbert, Faith Schiro, Pyone P. Aye, Robert V. Blair, Mauricio A. Martins, Kathrine P. Falkenstein, Amitinder Kaur, Christine L. Curry, Esper G. Kallas, Ronald C. Desrosiers, Pascal J. Goldschmidt-Clermont, Stephen S. Whitehead, Kristian G. Andersen, Myrna C. Bonaldo, Andrew A. Lackner, Antonito T. Panganiban, Dennis R. Burton & David I. Watkins. (2018) Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques. Nature Communications 9:1.
Crossref
Jenny Chia, Jade Louber, Isabelle Glauser, Shirley Taylor, Greg T. Bass, Steve K. Dower, Paul A. Gleeson & Anne M. Verhagen. (2018) Half-life–extended recombinant coagulation factor IX–albumin fusion protein is recycled via the FcRn-mediated pathway. Journal of Biological Chemistry 293:17, pages 6363-6373.
Crossref
Paul J. Carter & Greg A. Lazar. (2017) Next generation antibody drugs: pursuit of the 'high-hanging fruit'. Nature Reviews Drug Discovery 17:3, pages 197-223.
Crossref
Asa Ohsaki, Nicholas Venturelli, Tess M. Buccigrosso, Stavroula K. Osganian, John Lee, Richard S. Blumberg & Michiko K. Oyoshi. (2018) Maternal IgG immune complexes induce food allergen–specific tolerance in offspring. Journal of Experimental Medicine 215:1, pages 91-113.
Crossref
Sandor Kerpel-Fronius. (2018) A short review of the pharmacokinetic behavior of biological medicinal agents for the clinical practice. Microchemical Journal 136, pages 270-274.
Crossref
Carole Heath & Dean Pettit. 2018. Challenges in Protein Product Development. Challenges in Protein Product Development 545 558 .
Daniel Dixon, Serguei Tchessalov & Bakul Bhatnagar. 2018. Challenges in Protein Product Development. Challenges in Protein Product Development 407 439 .
Nina Wronkowitz, Thorsten Hartmann, Sven Wolfgang Görgens, Daniela Dietze‐Schroeder, Ira Indrakusuma, In Young Choi, Sung Hee Park, Young‐Mi Lee, Se Chang Kwon, Yeonjoo Kang, Marcus Hompesch & Jürgen Eckel. (2017) LAPS Insulin115 : A novel ultra‐long‐acting basal insulin with a unique action profile . Diabetes, Obesity and Metabolism 19:12, pages 1722-1731.
Crossref
Frank Driessler, Maricel G. Miguelino, Glenn F. Pierce, Robert T. Peters & Jurg M. Sommer. (2017) Evaluation of recombinant factor VIII Fc (Eloctate) activity by thromboelastometry in a multicenter phase 3 clinical trial and correlation with bleeding phenotype. Blood Coagulation & Fibrinolysis 28:7, pages 540-550.
Crossref
Yuki Shiga, Daisuke Murata, Akinori Sugimoto, Yuta Oshima, Minoru Tada, Akiko Ishii-Watabe, Kenichiro Imai, Kentaro Tomii, Takashi Takeuchi, Shinji Kagaya & Atsushi Sato. (2017) Hinge-Deficient IgG1 Fc Fusion: Application to Human Lactoferrin. Molecular Pharmaceutics 14:9, pages 3025-3035.
Crossref
James S. Foster, Angela D. Williams, Sallie Macy, Tina Richey, Alan Stuckey, Daniel Craig Wooliver, Richa Koul-Tiwari, Emily B. Martin, Stephen J. Kennel & Jonathan S. Wall. (2017) A Peptide-Fc Opsonin with Pan-Amyloid Reactivity. Frontiers in Immunology 8.
Crossref
Akinori Hishiya & Keizo Koya. (2017) Artificial DnaJ Protein for protein production and conformational diseases. Scientific Reports 7:1.
Crossref
Aleksandra Sokolowska-Wedzina, Grzegorz Chodaczek, Julia Chudzian, Aleksandra Borek, Malgorzata Zakrzewska & Jacek Otlewski. (2017) High-Affinity Internalizing Human scFv-Fc Antibody for Targeting FGFR1-Overexpressing Lung Cancer. Molecular Cancer Research 15:8, pages 1040-1050.
Crossref
Sheridan M. Hoy. (2017) Eftrenonacog Alfa: A Review in Haemophilia B. Drugs 77:11, pages 1235-1246.
Crossref
Li-Chun Zheng, Xiao-Qing Wang, Kun Lu, Xiao-Ling Deng, Cheng-Wei Zhang, Hong Luo, Xu-Dong Xu, Xiao-Man Chen, Lu Yan, Yi-Qing Wang & Song-Lin Shi. (2017) Ephrin-B2/Fc promotes proliferation and migration, and suppresses apoptosis in human umbilical vein endothelial cells. Oncotarget 8:25, pages 41348-41363.
Crossref
Tarianna Stewart, William T. Koval, Samuel A. Molina, Suzanne M. Bock, James W. LillardJr.Jr., Russell F. Ross, Tejal A. Desai & Michael Koval. (2017) Calibrated flux measurements reveal a nanostructure-stimulated transcytotic pathway. Experimental Cell Research 355:2, pages 153-161.
Crossref
D. Levin, H.A.D. Lagassé, E. Burch, S. Strome, S. Tan, H. Jiang, Z.E. Sauna & B. Golding. (2017) Modulating immunogenicity of factor IX by fusion to an immunoglobulin Fc domain: a study using a hemophilia B mouse model. Journal of Thrombosis and Haemostasis 15:4, pages 721-734.
Crossref
Maria Mancuso & Elena Santagostino. (2017) Outcome of Clinical Trials with New Extended Half-Life FVIII/IX Concentrates. Journal of Clinical Medicine 6:4, pages 39.
Crossref
Abdullah F. U. H. Saeed, Rongzhi Wang, Sumei Ling & Shihua Wang. (2017) Antibody Engineering for Pursuing a Healthier Future. Frontiers in Microbiology 8.
Crossref
Mark L. Brader, Edward N. Baker, Michael F. Dunn, Thomas M. Laue & John F. Carpenter. (2017) Using X-Ray Crystallography to Simplify and Accelerate Biologics Drug Development. Journal of Pharmaceutical Sciences 106:2, pages 477-494.
Crossref
Li Zhou, Hsuan-Yao Wang, Shanshan Tong, Curtis T. Okamoto, Wei-Chiang Shen & Jennica L. Zaro. (2017) Single chain Fc-dimer-human growth hormone fusion protein for improved drug delivery. Biomaterials 117, pages 24-31.
Crossref
H.A. Daniel Lagassé, Aikaterini Alexaki, Vijaya L. Simhadri, Nobuko H. Katagiri, Wojciech Jankowski, Zuben E. Sauna & Chava Kimchi-Sarfaty. (2017) Recent advances in (therapeutic protein) drug development. F1000Research 6, pages 113.
Crossref
K.John Pasi, Kathelijn Fischer, Margaret Ragni, Beatrice Nolan, David J. Perry, Roshni Kulkarni, Margareth Ozelo, Johnny Mahlangu, Amy D. Shapiro, Ross I. Baker, Carolyn M. Bennett, Christopher Barnes, Johannes Oldenburg, Tadashi Matsushita, Huixing Yuan, Alejandra Ramirez-Santiago, Glenn F. Pierce, Geoffrey Allen & Baisong Mei. (2017) Long-term safety and efficacy of extended-interval prophylaxis with recombinant factor IX Fc fusion protein (rFIXFc) in subjects with haemophilia B. Thrombosis and Haemostasis 117:03, pages 508-518.
Crossref
Kim Schafer, James Munn, Kate Khair, Neelam Thukral, Angela Tom & Sally McAlister. (2017) Pharmacokinetics, Safety, and Efficacy of Recombinant Factor VIII Fc Fusion Protein. Journal of Infusion Nursing 40:1, pages 65-75.
Crossref
Wenwen Dong, Hao Zhang, He Huang, Jianbo Zhou, Liping Hu, Ailing Lian, Lijun Zhu, Ningning Ma, Pingping Yang, Kai Wei & Ruiliang Zhu. (2016) Chicken IgY Fc Linked to Bordetella avium ompA and Taishan Pinus massoniana Pollen Polysaccharide Adjuvant Enhances Macrophage Function and Specific Immune Responses. Frontiers in Microbiology 7.
Crossref
Hyo Jung Julie Chang, Michael O'Boyle, Ronald C. Anderson & Chompoonut Suttikun. (2016) An fMRI study of advertising appeals and their relationship to product attractiveness and buying intentions. Journal of Consumer Behaviour 15:6, pages 538-548.
Crossref
Martin Whitham & Mark A. Febbraio. (2016) The ever-expanding myokinome: discovery challenges and therapeutic implications. Nature Reviews Drug Discovery 15:10, pages 719-729.
Crossref
Jiang-Jiang Qin, Wei Wang, Sushanta Sarkar & Ruiwen Zhang. (2016) Oral delivery of anti-MDM2 inhibitor SP141-loaded FcRn-targeted nanoparticles to treat breast cancer and metastasis. Journal of Controlled Release 237, pages 101-114.
Crossref
James E. Frampton. (2016) Efmoroctocog Alfa: A Review in Haemophilia A. Drugs 76:13, pages 1281-1291.
Crossref
P.M. Mannucci, M.E. Mancuso & M. Franchini. (2016) Tailoring hemostatic therapies to lower inhibitor development in previously untreated patients with severe hemophilia A. Journal of Thrombosis and Haemostasis 14:7, pages 1330-1336.
Crossref
P. Collins, E. Chalmers, P. Chowdary, D. Keeling, M. Mathias, J. O'Donnell, K. J. Pasi, S. Rangarajan & A. Thomas. (2016) The use of enhanced half‐life coagulation factor concentrates in routine clinical practice: guidance from UKHCDO . Haemophilia 22:4, pages 487-498.
Crossref
B. Brand, R. Gruppo, T. T. Wynn, L. Griskevicius, M. F. Lopez Fernandez, M. Chapman, T. Dvorak, B. G. Pavlova & B. E. Abbuehl. (2016) Efficacy and safety of pegylated full‐length recombinant factor VIII with extended half‐life for perioperative haemostasis in haemophilia A patients . Haemophilia 22:4.
Crossref
João Pedro Martins, Patrick J. Kennedy, Hélder A. Santos, Cristina Barrias & Bruno Sarmento. (2016) A comprehensive review of the neonatal Fc receptor and its application in drug delivery. Pharmacology & Therapeutics 161, pages 22-39.
Crossref
Yao-Yun Fan & Hendrik Neubert. (2016) Quantitative Analysis of Human Neonatal Fc Receptor (FcRn) Tissue Expression in Transgenic Mice by Online Peptide Immuno-Affinity LC-HRMS. Analytical Chemistry 88:8, pages 4239-4247.
Crossref
Saman Soleimanpour, Ali Mohammadi, Kiarash Ghazvini, Saeid Amel Jamehdar, Hamid Sadeghian, Mahboubeh Taghiabadi & S.A.R. Rezaee. (2016) Construction of Mycobacterium tuberculosis ESAT-6 fused to human Fcγ of IgG1: To target FcγR as a delivery system for enhancement of immunogenicity. Gene 580:2, pages 111-117.
Crossref
Stian Foss, Algirdas Grevys, Kine Marita Knudsen Sand, Malin Bern, Pat Blundell, Terje E. Michaelsen, Richard J. Pleass, Inger Sandlie & Jan Terje Andersen. (2016) Enhanced FcRn-dependent transepithelial delivery of IgG by Fc-engineering and polymerization. Journal of Controlled Release 223, pages 42-52.
Crossref
Manuel Carcao & Alok Srivastava. (2016) Factor VIII/factor IX prophylaxis for severe hemophilia. Seminars in Hematology 53:1, pages 3-9.
Crossref
Atsushi Furukawa, Katsumi Maenaka & Takao Nomura. 2016. Advanced Methods in Structural Biology. Advanced Methods in Structural Biology 67 81 .
Brian A. BaldoBrian A. Baldo. 2016. Safety of Biologics Therapy. Safety of Biologics Therapy 263 307 .
Jennifer A. Dumont, Kenneth S. Loveday, David R. Light, Glenn F. Pierce & Haiyan Jiang. (2015) Evaluation of the toxicology and pharmacokinetics of recombinant factor VIII Fc fusion protein in animals. Thrombosis Research 136:6, pages 1266-1272.
Crossref
Saman Soleimanpour, Hadi Farsiani, Arman Mosavat, Kiarash Ghazvini, Mohammad Reza Akbari Eydgahi, Mojtaba Sankian, Hamid Sadeghian, Zahra Meshkat & Seyed Abdolrahim Rezaee. (2015) APC targeting enhances immunogenicity of a novel multistage Fc-fusion tuberculosis vaccine in mice. Applied Microbiology and Biotechnology 99:24, pages 10467-10480.
Crossref
Keith Wycoff, James Maclean, Archana Belle, Lloyd Yu, Y Tran, Chad Roy & Frederick Hayden. (2015) Anti‐infective immunoadhesins from plants. Plant Biotechnology Journal 13:8, pages 1078-1093.
Crossref
Tal Noy-Porat, Ofer Cohen, Sharon Ehrlich, Eyal Epstein, Ron Alcalay & Ohad Mazor. (2015) Acetylcholinesterase-Fc Fusion Protein (AChE-Fc): A Novel Potential Organophosphate Bioscavenger with Extended Plasma Half-Life. Bioconjugate Chemistry 26:8, pages 1753-1758.
Crossref
G. Young, J. Mahlangu, R. Kulkarni, B. Nolan, R. Liesner, J. Pasi, C. Barnes, S. Neelakantan, G. Gambino, L. M. Cristiano, G. F. Pierce & G. Allen. (2015) Recombinant factor VIII Fc fusion protein for the prevention and treatment of bleeding in children with severe hemophilia A. Journal of Thrombosis and Haemostasis 13:6, pages 967-977.
Crossref
Michal Pyzik, Timo Rath, Wayne I. Lencer, Kristi Baker & Richard S. Blumberg. (2015) FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin. The Journal of Immunology 194:10, pages 4595-4603.
Crossref
Brian A. Baldo. (2015) Chimeric Fusion Proteins Used for Therapy: Indications, Mechanisms, and Safety. Drug Safety 38:5, pages 455-479.
Crossref
Daniel M. Czajkowsky, Jan Terje Andersen, Anja Fuchs, Timothy J. Wilson, David Mekhaiel, Marco Colonna, Jianfeng He, Zhifeng Shao, Daniel A. Mitchell, Gang Wu, Anne Dell, Stuart Haslam, Katy A. Lloyd, Shona C. Moore, Inger Sandlie, Patricia A. Blundell & Richard J. Pleass. (2015) Developing the IVIG biomimetic, Hexa-Fc, for drug and vaccine applications. Scientific Reports 5:1.
Crossref
Céline Monnet, Sylvie Jorieux, Rémi Urbain, Nathalie Fournier, Khalil Bouayadi, Christophe De Romeuf, Christian K. Behrens, Alexandre Fontayne & Philippe Mondon. (2015) Selection of IgG Variants with Increased FcRn Binding Using Random and Directed Mutagenesis: Impact on Effector Functions. Frontiers in Immunology 6.
Crossref
Timo Rath, Kristi Baker, Michal Pyzik & Richard S. Blumberg. (2015) Regulation of Immune Responses by the Neonatal Fc Receptor and Its Therapeutic Implications. Frontiers in Immunology 5.
Crossref
Ditza Levin, Basil Golding, Scott E. Strome & Zuben E. Sauna. (2015) Fc fusion as a platform technology: potential for modulating immunogenicity. Trends in Biotechnology 33:1, pages 27-34.
Crossref
Uli Binder & Arne Skerra. 2015. Biobetters. Biobetters 269 311 .
A. D. Shapiro, M. V. Ragni, R. Kulkarni, J. Oldenberg, A. Srivastava, D. V. Quon, K. J. Pasi, H. Hanabusa, I. Pabinger, J. Mahlangu, P. Fogarty, D. Lillicrap, S. Kulke, J. Potts, S. Neelakantan, I. Nestorov, S. Li, J. A. Dumont, H. Jiang, A. Brennan & G. F. Pierce. (2014) Recombinant factor  VIII Fc fusion protein: extended‐interval dosing maintains low bleeding rates and correlates with von W illebrand factor levels . Journal of Thrombosis and Haemostasis 12:11, pages 1788-1800.
Crossref
Jurg Sommer, Yang Buyue, Sara Bardan, Robert Peters, Haiyan Jiang, George Kamphaus, Elaine Gray & Glenn Pierce. (2017) Comparative field study: impact of laboratory assay variability on the assessment of recombinant factor IX Fc fusion protein (rFIXFc) activity. Thrombosis and Haemostasis 112:11, pages 932-940.
Crossref
Kristi Baker, Timo Rath, Michal Pyzik & Richard S. Blumberg. (2014) The Role of FcRn in Antigen Presentation. Frontiers in Immunology 5.
Crossref
J. McCue, D. Osborne, J. Dumont, R. Peters, B. Mei, G. F. Pierce, K. Kobayashi & D. Euwart. (2014) Validation of the manufacturing process used to produce long‐acting recombinant factor IX Fc fusion protein . Haemophilia 20:4.
Crossref
M. Carcao. (2014) Changing paradigm of prophylaxis with longer acting factor concentrates. Haemophilia 20, pages 99-105.
Crossref