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Understanding the metabolic basis of drug resistance

Therapeutic induction of the Warburg effect kills cancer cells

, , , , , , , , , & show all
Pages 2521-2528 | Received 20 May 2011, Accepted 25 May 2011, Published online: 01 Aug 2011

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Michael P. Lisanti, Ubaldo E. Martinez-Outschoorn & Federica Sotgia. (2013) Oncogenes induce the cancer-associated fibroblast phenotype: Metabolic symbiosis and “fibroblast addiction” are new therapeutic targets for drug discovery. Cell Cycle 12:17, pages 2723-2732.
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Ubaldo E Martinez-Outschoorn, Joseph M Curry, Ying-Hui Ko, Zhao Lin, Madalina Tuluc, David Cognetti, Ruth C Birbe, Edmund Pribitkin, Alessandro Bombonati, Richard G Pestell, Anthony Howell, Federica Sotgia & Michael P Lisanti. (2013) Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment. Cell Cycle 12:16, pages 2580-2597.
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Paola Avena, Wanda Anselmo, Chenguang Wang, Richard G. Pestell, Rebecca S. Lamb, Ivan Casaburi, Sebastiano Andò, Ubaldo E. Martinez-Outschoorn & Michael P. Lisanti. (2013) Compartment-specific activation of PPARγ governs breast cancer tumor growth, via metabolic reprogramming and symbiosis. Cell Cycle 12:9, pages 1360-1370.
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Rosa Sanchez-Alvarez, Ubaldo E. Martinez-Outschoorn, Zhao Lin, Rebecca Lamb, James Hulit, Anthony Howell, Federica Sotgia, Emanuel Rubin & Michael P. Lisanti. (2013) Ethanol exposure induces the cancer-associated fibroblast phenotype and lethal tumor metabolism. Cell Cycle 12:2, pages 289-301.
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Rosa Sanchez-Alvarez, Ubaldo E. Martinez-Outschoorn, Rebecca Lamb, James Hulit, Anthony Howell, Ricardo Gandara, Marina Sartini, Emanuel Rubin, Michael P. Lisanti & Federica Sotgia. (2013) Mitochondrial dysfunction in breast cancer cells prevents tumor growth. Cell Cycle 12:1, pages 172-182.
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Marion MacFarlane, Gemma L. Robinson & Kelvin Cain. (2012) Glucose—a sweet way to die. Cell Cycle 11:21, pages 3919-3925.
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Claudia Capparelli, Barbara Chiavarina, Diana Whitaker-Menezes, Timothy G. Pestell, Richard G. Pestell, James Hulit, Sebastiano Andò, Anthony Howell, Ubaldo E. Martinez-Outschoorn, Federica Sotgia & Michael P. Lisanti. (2012) CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, “fueling” tumor growth via paracrine interactions, without an increase in neo-angiogenesis. Cell Cycle 11:19, pages 3599-3610.
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Ahmed F. Salem, Diana Whitaker-Menezes, Zhao Lin, Ubaldo E. Martinez-Outschoorn, Herbert B. Tanowitz, Mazhar Salim Al-Zoubi, Anthony Howell, Richard G. Pestell, Federica Sotgia & Michael P. Lisanti. (2012) Two-compartment tumor metabolism: Autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells. Cell Cycle 11:13, pages 2545-2559.
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Agnieszka K. Witkiewicz, Diana Whitaker-Menezes, Abhijit Dasgupta, Nancy J. Philp, Zhao Lin, Ricardo Gandara, Sharon Sneddon, Ubaldo E. Martinez-Outschoorn, Federica Sotgia & Michael P. Lisanti. (2012) Using the “reverse Warburg effect” to identify high-risk breast cancer patients. Cell Cycle 11:6, pages 1108-1117.
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Alessandro Rimessi, Erika Zecchini, Roberta Siviero, Carlotta Giorgi, Sara Leo, Rosario Rizzuto & Paolo Pinton. (2012) The selective inhibition of nuclear PKCζ restores the effectiveness of chemotherapeutic agents in chemoresistant cells. Cell Cycle 11:5, pages 1040-1048.
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Adam Ertel, Aristotelis Tsirigos, Diana Whitaker-Menezes, Ruth Birbe, Stephanos Pavlides, Ubaldo E. Martinez-Outschoorn, Richard G. Pestell, Anthony Howell, Federica Sotgia & Michael P. Lisanti. (2012) Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism. Cell Cycle 11:2, pages 253-263.
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Ubaldo E. Martinez-Outschoorn, Richard G. Pestell, Anthony Howell, Mark L. Tykocinski, Fnu Nagajyothi, Fabiana S. Machado, Herbert B. Tanowitz, Federica Sotgia & Michael P. Lisanti. (2011) Energy transfer in "parasitic" cancer metabolism. Cell Cycle 10:24, pages 4208-4216.
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Barbara Chiavarina , Diana Whitaker-Menezes, Ubaldo E. Martinez-Outschoorn, Agnieszka K. Witkiewicz, Ruth Birbe, Anthony Howell, Richard G. Pestell, Johanna Smith, Rene Daniel, Federica Sotgia & Michael P. Lisanti. (2011) Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth. Cancer Biology & Therapy 12:12, pages 1101-1113.
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Ying-Hui Ko, Zhao Lin, Neal Flomenberg, Richard G. Pestell, Anthony Howell, Federica Sotgia, Michael P. Lisanti & Ubaldo E. Martinez-Outschoorn. (2011) Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells. Cancer Biology & Therapy 12:12, pages 1085-1097.
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Michael P Lisanti, Ubaldo E. Martinez-Outschoorn, Zhao Lin, Stephanos Pavlides, Diana Whitaker-Menezes, Richard G. Pestell, Anthony Howell & Federica Sotgia. (2011) Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis. Cell Cycle 10:15, pages 2440-2449.
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