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Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence

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Pages 2391-2401 | Published online: 15 Jun 2012

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Mikhail V. Blagosklonny. (2022) Cell senescence, rapamycin and hyperfunction theory of aging. Cell Cycle 21:14, pages 1456-1467.
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Matthew J. Payea, Carlos Anerillas, Ravi Tharakan & Myriam Gorospe. (2021) Translational Control during Cellular Senescence. Molecular and Cellular Biology 41:2.
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Reeja S. Maskey, Fang Wang, Elyssa Lehman, Yiqun Wang, Natasha Emmanuel, Wenyan Zhong, Guixian Jin, Robert T. Abraham, Kim T. Arndt, Jeremy S. Myers & Anthony Mazurek. (2021) Sustained mTORC1 activity during palbociclib-induced growth arrest triggers senescence in ER+ breast cancer cells. Cell Cycle 20:1, pages 65-80.
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Mikhail V. Blagosklonny. (2018) Rapamycin, proliferation and geroconversion to senescence. Cell Cycle 17:24, pages 2655-2665.
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Véronique Gire & Vjekoslav Dulić. (2015) Senescence from G2 arrest, revisited. Cell Cycle 14:3, pages 297-304.
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Mikhail V Blagosklonny. (2014) Geroconversion: irreversible step to cellular senescence. Cell Cycle 13:23, pages 3628-3635.
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Olga V Leontieva, Geraldine M Paszkiewicz & Mikhail V Blagosklonny. (2014) Comparison of rapamycin schedules in mice on high-fat diet. Cell Cycle 13:21, pages 3350-3356.
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Olga V Leontieva, Geraldine M Paszkiewicz & Mikhail V Blagosklonny. (2014) Fasting levels of hepatic p-S6 are increased in old mice. Cell Cycle 13:17, pages 2656-2659.
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Xavier Deschênes-Simard, Frédéric Lessard, Marie-France Gaumont-Leclerc, Nabeel Bardeesy & Gerardo Ferbeyre. (2014) Cellular senescence and protein degradation. Cell Cycle 13:12, pages 1840-1858.
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Zhanna V Chitikova, Serguei A Gordeev, Tatiana V Bykova, Svetlana G Zubova, Valery A Pospelov & Tatiana V Pospelova. (2014) Sustained activation of DNA damage response in irradiated apoptosis-resistant cells induces reversible senescence associated with mTOR downregulation and expression of stem cell markers. Cell Cycle 13:9, pages 1424-1439.
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Olga V. Leontieva & Mikhail V Blagosklonny. (2014) M(o)TOR of pseudo-hypoxic state in aging: Rapamycin to the rescue. Cell Cycle 13:4, pages 509-515.
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Tatyana V. Pospelova, Tatiana V Bykova, Svetlana G Zubova, Natalia V Katolikova, Natalia M Yartzeva & Valery A Pospelov. (2013) Rapamycin induces pluripotent genes associated with avoidance of replicative senescence. Cell Cycle 12:24, pages 3841-3851.
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Mikhail V Blagosklonny. (2013) Aging is not programmed. Cell Cycle 12:24, pages 3736-3742.
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Mikhail V Blagosklonny. (2013) Immunosuppressants in cancer prevention and therapy. OncoImmunology 2:12.
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Olga V Leontieva, Liliya R Novototskaya, Geraldine M Paszkiewicz, Elena A Komarova, Andrei V Gudkov & Mikhail V Blagosklonny. (2013) Dysregulation of the mTOR pathway in p53-deficient mice. Cancer Biology & Therapy 14:12, pages 1182-1188.
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Christoph Garbers, Fabian Kuck, Samadhi Aparicio-Siegmund, Kirstin Konzak, Mareike Kessenbrock, Annika Sommerfeld, Dieter Häussinger, Philipp Lang, Dirk Brenner, Tak Wah Mak, Stefan Rose-John, Frank Essmann, Klaus Schulze-Osthoff, Roland Piekorz & Jürgen Scheller. (2013) Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR). Cell Cycle 12:21, pages 3421-3432.
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Olga V. Leontieva & Mikhail V Blagosklonny. (2013) S6K in geroconversion. Cell Cycle 12:20, pages 3249-3252.
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BRUNA COROMINAS-FAJA, SÍLVIA CUFÍ, Cristina Oliveras-Ferraros, ELISABET CUYÀS, Eugeni López-Bonet, RUTH LUPU, TOMÁS ALARCÓN, Luciano Vellon, JUAN MANUEL IGLESIAS, OLATZ LEIS, Angel Martin, Alejandro Vazquez-Martin & Javier A. Menendez. (2013) Nuclear reprogramming of luminal-like breast cancer cells generates Sox2-overexpressing cancer stem-like cellular states harboring transcriptional activation of the mTOR pathway. Cell Cycle 12:18, pages 3109-3124.
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Michael G Garelick, Vivian L MacKay, Aya Yanagida, Emmeline C Academia, Katherine H Schreiber, Warren C Ladiges & Brian K Kennedy. (2013) Chronic rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo. Cell Cycle 12:15, pages 2493-2504.
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Mikhail V. Blagosklonny. (2012) Rapalogs in cancer prevention. Cancer Biology & Therapy 13:14, pages 1349-1354.
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Olga V. Leontieva & Mikhail V Blagosklonny. (2012) Hypoxia and gerosuppression: The mTOR saga continues. Cell Cycle 11:21, pages 3926-3931.
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Eros Lazzerini Denchi. (2012) A critical role for TORC1 in cellular senescence. Cell Cycle 11:16, pages 2976-2976.
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Manuel Serrano. (2012) Dissecting the role of mTOR complexes in cellular senescence. Cell Cycle 11:12, pages 2231-2232.
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Tatyana V. Pospelova, Olga V. Leontieva, Tatiana V. Bykova, Svetlana G. Zubova, Valery A. Pospelov & Mikhail V. Blagosklonny. (2012) Suppression of replicative senescence by rapamycin in rodent embryonic cells. Cell Cycle 11:12, pages 2402-2407.
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