Expert Opinion on Drug Discovery, Volume 17, Issue 5 (2022)

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Expert Opinion on Drug Discovery, Volume 17, Issue 5 (2022)

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Editorial

Editorial
What are the current challenges for machine learning in drug discovery and repurposing?
Tero Aittokallio
Pages: 423-425
Published online: 08 Mar 2022
First Page PreviewforWhat are the current challenges for machine learning in drug discovery and repurposing? | Full Text | References | PDF (167.7 KB) | EPUB
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Drug Discovery Case History

Article
An overview of the preclinical discovery and development of trastuzumab deruxtecan: a novel gastric cancer therapeutic
James Kalmuk, Dan Rinder, Carl Heltzel & Albert Craig Lockhart
Pages: 427-436
Published online: 15 Apr 2022
AbstractforAn overview of the preclinical discovery and development of trastuzumab deruxtecan: a novel gastric cancer therapeutic | Full Text | References | PDF (1.6 MB) | EPUB
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Special Report

Article
Novel strategies for targeting the thioredoxin system for cancer therapy
Qianhe Xu & Junmin Zhang
Pages: 437-442
Published online: 27 Feb 2022
AbstractforNovel strategies for targeting the thioredoxin system for cancer therapy | Full Text | References | PDF (1.8 MB) | EPUB
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Review

Targeting the cytoskeleton and extracellular matrix in cardiovascular disease drug discovery
Bohdan B. Khomtchouk, Yoon Seo Lee, Maha L. Khan, Patrick Sun, Deniel Mero & Michael H. Davidson
Pages: 443-460
Published online: 08 Mar 2022
AbstractforTargeting the cytoskeleton and extracellular matrix in cardiovascular disease drug discovery | Full Text | References | PDF (2.5 MB) | EPUB
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Article
Advances in computer-aided drug design for type 2 diabetes
Wanqiu Huang, Luyong Zhang & Zheng Li
Pages: 461-472
Published online: 07 Mar 2022
AbstractforAdvances in computer-aided drug design for type 2 diabetes | Full Text | References | PDF (4.8 MB) | EPUB
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Antimicrobial peptides: A plausible approach for COVID-19 treatment
Pooja Rani, Bhupinder Kapoor, Monica Gulati, Atanas G. Atanasov, Qushmua Alzahrani & Reena Gupta
Pages: 473-487
Published online: 09 Mar 2022
AbstractforAntimicrobial peptides: A plausible approach for COVID-19 treatment | Full Text | References | PDF (4.1 MB) | EPUB
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Animal models of systemic lupus erythematosus and their applications in drug discovery
Yue Xin, Bo Zhang, Junpeng Zhao, Qianmei Liu, Haoyuan Yin & Qianjin Lu
Pages: 489-500
Published online: 14 Mar 2022
AbstractforAnimal models of systemic lupus erythematosus and their applications in drug discovery | Full Text | References | PDF (411.2 KB) | EPUB
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The importance of sulfur-containing motifs in drug design and discovery
Muhamad Mustafa & Jean-Yves Winum
Pages: 501-512
Published online: 25 Feb 2022
AbstractforThe importance of sulfur-containing motifs in drug design and discovery | Full Text | References | PDF (2.1 MB) | EPUB
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Frankincense diterpenes as a bio-source for drug discovery
Hidayat Hussain, Luay Rashan, Uzma Hassan, Muzaffar Abbas, Faruck L. Hakkim & Ivan R. Green
Pages: 513-529
Published online: 04 Mar 2022
AbstractforFrankincense diterpenes as a bio-source for drug discovery | Full Text | References | PDF (868.7 KB) | EPUB
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