Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 28, Issue 6 (2013)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 28, Issue 6 (2013)

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Review Article

Review Article
Enzymatic biotransformation of terpenes as bioactive agents
Nighat Sultana & Zafar Saeed Saify
Pages: 1113-1128
Published online: 09 Oct 2012
AbstractforEnzymatic biotransformation of terpenes as bioactive agents | Full Text | References | PDF (2.9 MB)
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Article
An update on carbonic anhydrase-related proteins VIII, X and XI
Ashok Aspatwar, Martti E. E. Tolvanen & Seppo Parkkila
Pages: 1129-1142
Published online: 07 Jan 2013
AbstractforAn update on carbonic anhydrase-related proteins VIII, X and XI | Full Text | References | PDF (1.7 MB)
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Research Article

Article
Antioxidant activity of indole-based melatonin analogues in erythrocytes and their voltammetric characterization
Sibel Suzen, Betul Tekiner-Gulbas, Hanif Shirinzadeh, Duysal Uslu, Hande Gurer-Orhan, Mehmet Gumustas & Sibel Aysil Ozkan
Pages: 1143-1155
Published online: 20 Sep 2012
AbstractforAntioxidant activity of indole-based melatonin analogues in erythrocytes and their voltammetric characterization | Full Text | References | PDF (931.1 KB)
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Article
Urease inhibitory isoflavonoids from different parts of Calopogonium mucunoides (Fabaceae)
Brigitte Ndemangou, Valerie Tedjon Sielinou, Juliette Catherine Vardamides, Muhammad Shaiq Ali, Mehreen Lateef, Lubna Iqbal, Nigaht Afza & Augustin Ephrem Nkengfack
Pages: 1156-1161
Published online: 11 Oct 2012
AbstractforUrease inhibitory isoflavonoids from different parts of Calopogonium mucunoides (Fabaceae) | Full Text | References | PDF (746 KB)
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Article
Structure-activity relationships of bergenin derivatives effect on α-glucosidase inhibition
Yusei Kashima, Hidehiko Yamaki, Takuya Suzuki & Mitsuo Miyazawa
Pages: 1162-1170
Published online: 26 Sep 2012
AbstractforStructure-activity relationships of bergenin derivatives effect on α-glucosidase inhibition | Full Text | References | PDF (878.2 KB)
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Article
Molecular modeling study bioactive natural product of khellin analogues as a novel potential pharmacophore of EGFR inhibitors
Abdel-Sattar S. Hamad Elgazwy, Mastoura M. Edrees & Nasser S. M. Ismail
Pages: 1171-1181
Published online: 01 Oct 2012
AbstractforMolecular modeling study bioactive natural product of khellin analogues as a novel potential pharmacophore of EGFR inhibitors | Full Text | References | PDF (1.7 MB)
  • 1343 Views
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Article
Mechanism of the plant cytochrome P450 for herbicide resistance: a modelling study
Qinfan Li, Yupeng Fang, Xiuxiu Li, Hong Zhang, Mengmeng Liu, Huibin Yang, Zhuo Kang, Yan Li & Yonghua Wang
Pages: 1182-1191
Published online: 11 Oct 2012
AbstractforMechanism of the plant cytochrome P450 for herbicide resistance: a modelling study | Full Text | References | PDF (991.1 KB)
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Article
Synthesis, cytotoxic evaluation, docking and in silico pharmacokinetic prediction of 4-arylideneamino/cycloalkylidineamino 1, 2-naphthoquinone thiosemicarbazones
Shubhanjali Shukla, Radhey Shyam Srivastava, Sushant Kumar Shrivastava, Ajit Sodhi & Pankaj Kumar
Pages: 1192-1198
Published online: 14 Sep 2012
AbstractforSynthesis, cytotoxic evaluation, docking and in silico pharmacokinetic prediction of 4-arylideneamino/cycloalkylidineamino 1, 2-naphthoquinone thiosemicarbazones | Full Text | References | PDF (842.8 KB) | Supplemental
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Article
Synthesis and characterization of 5,7-dihydroxyflavanone derivatives as novel protein tyrosine phosphatase 1B inhibitors
Liang-Peng Sun, Wei-Ping Ma, Li-Xin Gao, Ling-Ling Yang, Ying-Chun Quan, Jia Li & Hu-Ri Piao
Pages: 1199-1204
Published online: 26 Sep 2012
AbstractforSynthesis and characterization of 5,7-dihydroxyflavanone derivatives as novel protein tyrosine phosphatase 1B inhibitors | Full Text | References | PDF (830.2 KB)
  • 976 Views
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Article
Synthesis and antidiabetic activity of 2,4-thiazolidindione, imidazolidinedione and 2-thioxo-imidazolidine-4-one derivatives bearing 6-methyl chromonyl pharmacophore
Meltem Ceylan Unlusoy, Canan Kazak, Ornela Bayro, Eugen J. Verspohl, Rahmiye Ertan & Oya Bozdag Dundar
Pages: 1205-1210
Published online: 12 Oct 2012
AbstractforSynthesis and antidiabetic activity of 2,4-thiazolidindione, imidazolidinedione and 2-thioxo-imidazolidine-4-one derivatives bearing 6-methyl chromonyl pharmacophore | Full Text | References | PDF (745.7 KB)
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Article
Synthesis and antifungal activity of new hydrazide derivatives
Gülhan Turan-Zitouni, Mehlika Dilek Altıntop, Ahmet Özdemir, Fatih Demirci, Usama Abu Mohsen & Zafer Asım Kaplancıklı
Pages: 1211-1216
Published online: 26 Sep 2012
AbstractforSynthesis and antifungal activity of new hydrazide derivatives | Full Text | References | PDF (698.1 KB)
  • 972 Views
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Article
Stabilization of Aspergillus parasiticus cytosine deaminase by immobilization on calcium alginate beads improved enzyme operational stability
H. Zanna, A. J. Nok, S. Ibrahim & H. M. Inuwa
Pages: 1217-1220
Published online: 03 Oct 2012
AbstractforStabilization of Aspergillus parasiticus cytosine deaminase by immobilization on calcium alginate beads improved enzyme operational stability | Full Text | References | PDF (957.1 KB)
  • 471 Views
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Article
Synthesis of 1-acetyl-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives and evaluation of their anticancer activity
Ahmet Özdemir, Mehlika Dilek Altıntop, Zafer Asım Kaplancıklı, Gülhan Turan-Zitouni, Gülşen Akalın Çiftçi & Şafak Ulusoylar Yıldırım
Pages: 1221-1227
Published online: 01 Oct 2012
AbstractforSynthesis of 1-acetyl-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives and evaluation of their anticancer activity | Full Text | References | PDF (833.2 KB) | Supplemental
  • 1010 Views
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Article
Pyrimidine-fused heterocycle derivatives as a novel class of inhibitors for α-glucosidase
Reza Yousefi, Mohammad-Mehdi Alavian-Mehr, Fatemeh Mokhtari, Farhad Panahi, Mohammad H. Mehraban & Ali Khalafi-Nezhad
Pages: 1228-1235
Published online: 08 Oct 2012
AbstractforPyrimidine-fused heterocycle derivatives as a novel class of inhibitors for α-glucosidase | Full Text | References | PDF (840.4 KB)
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Article
Pharmacophore based 3D-QSAR modeling and free energy analysis of VEGFR-2 inhibitors
Muthukumaran Rajagopalan, Sangeetha Balasubramanian, Amutha Ramaswamy & Premendu Prakash Mathur
Pages: 1236-1246
Published online: 15 Oct 2012
AbstractforPharmacophore based 3D-QSAR modeling and free energy analysis of VEGFR-2 inhibitors | Full Text | References | PDF (1.3 MB) | Supplemental
  • 1150 Views
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Article
In vivo and in vitro effect of androstene derivatives as 5α-reductase type 1 enzyme inhibitors
Eugene Bratoeff, Araceli Sánchez, Yazmín Arellano, Yvonne Heuze, Juan Soriano & Marisa Cabeza
Pages: 1247-1254
Published online: 10 Oct 2012
AbstractforIn vivo and in vitro effect of androstene derivatives as 5α-reductase type 1 enzyme inhibitors | Full Text | References | PDF (959 KB)
  • 779 Views
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Article
Microwave-assisted synthesis of sec/tert-butyl 2-arylbenzimidazoles and their unexpected antiproliferative activity towards ER negative breast cancer cells
Aisyah Saad Abdul Rahim, Salizawati Muhamad Salhimi, Natarajan Arumugam, Lim Chung Pin, Ng Shy Yee, Nithya Niranjini Muttiah, Wong Boon Keat, Shafida Abd. Hamid, Hasnah Osman & Ishak b. Mat
Pages: 1255-1260
Published online: 15 Oct 2012
AbstractforMicrowave-assisted synthesis of sec/tert-butyl 2-arylbenzimidazoles and their unexpected antiproliferative activity towards ER negative breast cancer cells | Full Text | References | PDF (686.6 KB)
  • 750 Views
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Article
Effects of some metal ions on rainbow trout erythrocytes glutathione S-transferase enzyme: an in vitro study
Veysel Comakli, Mehmet Ciftci & O. Irfan Kufrevioglu
Pages: 1261-1266
Published online: 12 Oct 2012
AbstractforEffects of some metal ions on rainbow trout erythrocytes glutathione S-transferase enzyme: an in vitro study | Full Text | References | PDF (830.7 KB)
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Article
Synthesis and antimalarial activity of urenyl Bis-chalcone in vitro and in vivo
José N. Domínguez, Neira Gamboa de Domínguez, Juan Rodrigues, María Eugenia Acosta, Noris Caraballo & Caritza León
Pages: 1267-1273
Published online: 24 Oct 2012
AbstractforSynthesis and antimalarial activity of urenyl Bis-chalcone in vitro and in vivo | Full Text | References | PDF (861.5 KB)
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Article
Ligand design, synthesis and biological anti-HCV evaluations for genotypes 1b and 4a of certain 4-(3- & 4-[3-(3,5-dibromo-4-hydroxyphenyl)-propylamino]phenyl) butyric acids and 3-(3,5-dibromo-4-hydroxyphenyl)-propylamino-acetamidobenzoic acid esters
Mohamed Abdel Hamid Ismail, Khaled A. M. Abouzid, Nasser Saad Mohamed & Eman Mahmoud Elawady Dokla
Pages: 1274-1290
Published online: 07 Jan 2013
AbstractforLigand design, synthesis and biological anti-HCV evaluations for genotypes 1b and 4a of certain 4-(3- & 4-[3-(3,5-dibromo-4-hydroxyphenyl)-propylamino]phenyl) butyric acids and 3-(3,5-dibromo-4-hydroxyphenyl)-propylamino-acetamidobenzoic acid esters | Full Text | References | PDF (1 MB) | Supplemental
  • 882 Views
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Article
In vitro antibacterial, antifungal and cytotoxic activities of some triazole Schiff bases and their oxovanadium(IV) complexes
Sajjad H. Sumrra & Zahid H. Chohan
Pages: 1291-1299
Published online: 02 Nov 2012
AbstractforIn vitro antibacterial, antifungal and cytotoxic activities of some triazole Schiff bases and their oxovanadium(IV) complexes | Full Text | References | PDF (702.3 KB) | Supplemental
  • 1049 Views
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Article
Potential antitumour and pro-oxidative effects of (E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4-hydroxyphenyl) acrylate (QNACR)
Juan R. Rodrigues, Rosa Ferrer, Neira Gamboa, Jaime Charris & Fernando Antunes
Pages: 1300-1306
Published online: 09 Nov 2012
AbstractforPotential antitumour and pro-oxidative effects of (E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4-hydroxyphenyl) acrylate (QNACR) | Full Text | References | PDF (705.2 KB) | Supplemental
  • 440 Views
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Article
Microwave-assisted synthesis of antimicrobial agents based on pyridazine moiety
Mansoura I. Mohamed, Howida T. Zaky & Nadia G. Kandile
Pages: 1307-1315
Published online: 19 Nov 2012
AbstractforMicrowave-assisted synthesis of antimicrobial agents based on pyridazine moiety | Full Text | References | PDF (1.6 MB)
  • 621 Views
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Article
Synthesis and biological evaluation of novel series of aminopyrimidine derivatives as urease inhibitors and antimicrobial agents
Laxman K. Adsul, Babasaheb P. Bandgar, Hemant V. Chavan, Shivkumar S. Jalde, Valmik D. Dhakane & Amol L. Shirfule
Pages: 1316-1323
Published online: 11 Dec 2012
AbstractforSynthesis and biological evaluation of novel series of aminopyrimidine derivatives as urease inhibitors and antimicrobial agents | Full Text | References | PDF (817.3 KB)
  • 1262 Views
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Article
Repetitive intraperitoneal caspase-3 inhibitor and anesthesia reduces neuronal damage
Eduardo Chaparro, Diana Erasso, Carolina Quiroga, Gerardo Bosco, Andrea Parmagnani, Alessandro Rubini, Devanand Mangar & Enrico Camporesi
Pages: 1324-1330
Published online: 03 Dec 2012
AbstractforRepetitive intraperitoneal caspase-3 inhibitor and anesthesia reduces neuronal damage | Full Text | References | PDF (844.4 KB)
  • 539 Views
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Article
Molecular modelling design, synthesis and cytotoxic evaluation of certain substituted 2-(3,4,5-triacetoxybenzoylamino)benzo[d]thiazole and 2-(galloylamino)benzo[d]thiazole derivatives having potential topoisomerase-I inhibitory activity
Mohamed A. H. Ismail, Christophe Tratrat & Michelyne G. Haroun
Pages: 1331-1345
Published online: 07 Sep 2012
AbstractforMolecular modelling design, synthesis and cytotoxic evaluation of certain substituted 2-(3,4,5-triacetoxybenzoylamino)benzo[d]thiazole and 2-(galloylamino)benzo[d]thiazole derivatives having potential topoisomerase-I inhibitory activity | Full Text | References | PDF (1.1 MB) | Supplemental
  • 783 Views
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