16,473
Views
580
CrossRef citations to date
0
Altmetric
Review Article

Polymorphism of human cytochrome P450 enzymes and its clinical impact

, &
Pages 89-295 | Accepted 24 Feb 2009, Published online: 01 May 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (79)

Mengxu Zhang, Vivi Rottschäfer & Elizabeth C. M. de Lange. (2024) The potential impact of CYP and UGT drug-metabolizing enzymes on brain target site drug exposure. Drug Metabolism Reviews 56:1, pages 1-30.
Read now
Eman AlHussain A. Gawad, Mevidette El Madani, Hanan Mostafa & Radwa Marwan Abdel halim. (2023) Precision medicine as a predictive factor for risk of hospitalization of recurrent ischemic stroke patients treated with low dose aspirin. A pilot study. Egyptian Journal of Anaesthesia 39:1, pages 157-166.
Read now
Gabriel Felix da Silva Gomes, Priscila Goes Camargo, Kaio Maciel de Santiago-Silva, Helena Tiemi Suzukawa, Ana Paula Sotero da Silva Ribeiro, Alexandre Orsato, Gerson Nakazato, Sueli Fumie Yamada-Ogatta, Ligia Carla Faccin-Galhardi, Camilo Henrique da Silva Lima, Marcelle de Lima Ferreira Bispo & Carla Cristina Perez. (2023) In silico approaches and in vitro assays identify a coumarin derivative as antiviral potential against SARS-CoV-2. Journal of Biomolecular Structure and Dynamics 41:18, pages 8978-8991.
Read now
Min Zhang, Bin Wang, Xu-ting Li, Qin Yin, Ge Liang & Si-cong Li. (2023) Impact of tectoridin on the pharmacokinetics of florfenicol via targeting cytochrome P450 and P-glycoprotein of rats. Xenobiotica 53:5, pages 429-437.
Read now
Michiaki Kojima, Kanami Machida, Sumie Cho, Daichi Watanabe, Hiroyuki Seki, Miyuki Shimoji, Ayuko Imaoka, Hiroshi Yamazaki, F. Peter Guengerich, Katsunori Nakamura, Koujirou Yamamoto, Takeshi Akiyoshi & Hisakazu Ohtani. (2023) The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro. Xenobiotica 53:5, pages 357-365.
Read now
Aymen Shatnawi, Zourayz Kamran & Qusai Al-Share. (2023) Pharmacogenomics of Lipid-Lowering Agents: the Impact on Efficacy and Safety. Personalized Medicine 20:1, pages 65-86.
Read now
Benjamin J. Maldonato, Ana G. Vergara, Jaydeep Yadav, Sarah M. Glass, Erickson M. Paragas, Dongying Li, Philip Lazarus, Joseph L. McClay, Baitang Ning, Ann K. Daly & Laura E. Russell. (2022) Epigenetics in drug disposition & drug therapy: symposium report of the 24th North American meeting of the International Society for the Study of Xenobiotics (ISSX). Drug Metabolism Reviews 54:3, pages 318-330.
Read now
Isisdoris Rodrigues de Souza, Patrícia Savio de Araujo-Souza & Daniela Morais Leme. (2022) Genetic variants affecting chemical mediated skin immunotoxicity. Journal of Toxicology and Environmental Health, Part B 25:2, pages 43-95.
Read now
Tingting Zhang, Qiuyan Li, Bonan Dong, Xiao Liang, Mansha Jia, Jing Bai, Jingcui Yu & Songbin Fu. (2021) Genetic Polymorphism of Drug Metabolic Gene CYPs, VKORC1, NAT2, DPYD and CHST3 of Five Ethnic Minorities in Heilongjiang Province, Northeast China. Pharmacogenomics and Personalized Medicine 14, pages 1537-1547.
Read now
Yuliang Wang, Linna Peng, Hongyan Lu, Zhanhao Zhang, Shishi Xing, Dandan Li, Chunjuan He, Tianbo Jin & Li Wang. (2021) Genetic Polymorphisms of Very Important Pharmacogene Variants in the Blang Population from Yunnan Province in China. Pharmacogenomics and Personalized Medicine 14, pages 1647-1660.
Read now
Sicong Li, Xuting Li, Dingsheng Yuan, Bin Wang, Rui Yang, Min Zhang, Jinliang Li & Fuqiang Zeng. (2021) Effects of paeoniflorin on the activities and mRNA expression of rat CYP1A2, CYP2C11 and CYP3A1 enzymes in vivo. Xenobiotica 51:9, pages 961-967.
Read now
Jian-Chang Qian, Jian-Ping Cai & Guo-Xin Hu. (2021) Han Chinese specific cytochrome P450 polymorphisms and their impact on the metabolism of anti-hypertensive drugs with adrenoreceptor blocking properties. Expert Opinion on Drug Metabolism & Toxicology 17:6, pages 707-716.
Read now
Hang-Xing Huang, He Wu, Yingying Zhao, Tao Zhou, Xin Ai, Yu Dong, Yan Zhang & Yong Lai. (2021) Effect of CYP2C9 genetic polymorphism and breviscapine on losartan pharmacokinetics in healthy subjects. Xenobiotica 51:5, pages 616-623.
Read now
Rosemary H. Waring. (2020) Cytochrome P450: genotype to phenotype. Xenobiotica 50:1, pages 9-18.
Read now
Alan David Kaye, Andrew Jesse Garcia, O Morgan Hall, George M Jeha, Kelsey D Cramer, Amanda L Granier, Anusha Kallurkar, Elyse M Cornett & Richard D Urman. (2019) Update on the pharmacogenomics of pain management. Pharmacogenomics and Personalized Medicine 12, pages 125-143.
Read now
Yan Xuhong, Zhang Sinong, Liang Jianping, Cai Yu, Zhu Juanli, Zhang Chao, Li Desheng, Hua Kai, Cui Yali & Hui Wenli. (2019) A PCR-lateral flow assay system based on gold magnetic nanoparticles for CYP2C19 genotyping and its clinical applications. Artificial Cells, Nanomedicine, and Biotechnology 47:1, pages 636-643.
Read now
Xiuli Feng, Yan Liu, Xiao Sun, Ang Li, Xiaoyan Jiang, Xiaosong Zhu & Zhongxi Zhao. (2019) Pharmacokinetics behaviors of l-menthol after inhalation and intravenous injection in rats and its inhibition effects on CYP450 enzymes in rat liver microsomes. Xenobiotica 49:10, pages 1183-1191.
Read now
Dongying Li, William H. Tolleson, Dianke Yu, Si Chen, Lei Guo, Wenming Xiao, Weida Tong & Baitang Ning. (2019) Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis. Journal of Environmental Science and Health, Part C 37:3, pages 180-214.
Read now
Yuqing Gong, Sanjana Haque, Pallabita Chowdhury, Theodore J. Cory, Sunitha Kodidela, Murali M. Yallapu, John M. Norwood & Santosh Kumar. (2019) Pharmacokinetics and pharmacodynamics of cytochrome P450 inhibitors for HIV treatment. Expert Opinion on Drug Metabolism & Toxicology 15:5, pages 417-427.
Read now
David M. Taylor & Ursula Werneke. (2018) Ethnopharmacology†. Nordic Journal of Psychiatry 72:sup1, pages S30-S32.
Read now
Vitchan Kim, Sora Yeom, Yejin Lee, Hyoung-Goo Park, Myung-A Cho, Harim Kim & Donghak Kim. (2018) In vitro functional analysis of human cytochrome P450 2A13 genetic variants: P450 2A13*2, *3, *4, and *10. Journal of Toxicology and Environmental Health, Part A 81:12, pages 493-501.
Read now
Alan Talevi. (2018) Drug repositioning: current approaches and their implications in the precision medicine era. Expert Review of Precision Medicine and Drug Development 3:1, pages 49-61.
Read now
Huaqiao Tang, Nana Long, Min Dai, Lin Lin, Jianlong Li, Fenghui Sun & Lijuan Guo. (2018) Effect of citral on mouse hepatic cytochrome P450 enzymes. Pharmaceutical Biology 56:1, pages 337-343.
Read now
Jens Borggaard Larsen & Jan Borg Rasmussen. (2017) Pharmacogenetic testing revisited: 5′ nuclease real-time polymerase chain reaction test panels for genotyping CYP2D6 and CYP2C19. Pharmacogenomics and Personalized Medicine 10, pages 115-128.
Read now
Jarrett R. Amsden & Paul O. Gubbins. (2017) Pharmacogenomics of triazole antifungal agents: implications for safety, tolerability and efficacy. Expert Opinion on Drug Metabolism & Toxicology 13:11, pages 1135-1146.
Read now
Muh Akbar Bahar, Didik Setiawan, Eelko Hak & Bob Wilffert. (2017) Pharmacogenetics of Drug–Drug Interaction and Drug–Drug–Gene Interaction: A Systematic Review on CYP2C9, CYP2C19 and CYP2D6. Pharmacogenomics 18:7, pages 701-739.
Read now
Mamoonah Chaudhry, Marco Alessandrini, Jacobus Rademan, Tyren M Dodgen, Francois E Steffens, Danie G van Zyl, Andrea Gaedigk & Michael S Pepper. (2017) Impact of CYP2D6 Genotype on Amitriptyline Efficacy for the Treatment of Diabetic Peripheral Neuropathy: A Pilot Study. Pharmacogenomics 18:5, pages 433-443.
Read now
Sonya Ting & Stephan Schug. (2016) The pharmacogenomics of pain management: prospects for personalized medicine. Journal of Pain Research 9, pages 49-56.
Read now
Ren-ai Xu, Er-min Gu, Quan Zhou, Lingjing Yuan, Xiaoxia Hu, Jianping Cai & Guoxin Hu. (2016) Effects of 22 novel CYP2D6 variants found in Chinese population on the metabolism of dapoxetine. Drug Design, Development and Therapy 10, pages 687-696.
Read now
Zhe Wang, Li Wang, Ren-ai Xu, Yun-yun Zhan, Cheng-ke Huang, Da-peng Dai, Jian-ping Cai & Guo-xin Hu. (2016) Role of cytochrome P450 2D6 genetic polymorphism in carvedilol hydroxylation in vitro. Drug Design, Development and Therapy 10, pages 1909-1916.
Read now
Qinghua Weng, Bingqing Liang, Yali Zhou, Xiangyu Li, Hao Wang, Yunyun Zhan, Dapeng Dai, JianPing Cai & Guoxin Hu. (2016) Effect of 24 cytochrome P450 2D6 variants found in the Chinese population on the N-demethylation of amitriptyline in vitro. Pharmaceutical Biology 54:11, pages 2475-2479.
Read now
Vinicius A Sortica, Juliana D Lindenau, Maristela G Cunha, Maria DO Ohnishi, Ana Maria R Ventura, Ândrea KC Ribeiro-dos-Santos, Sidney EB Santos, Luciano SP Guimarães & Mara H Hutz. (2016) The Effect of SNPs in CYP450 in Chloroquine/Primaquine Plasmodium Vivax Malaria Treatment. Pharmacogenomics 17:17, pages 1903-1911.
Read now
Tianbo Jin, Mingxia Zhang, Hua Yang, Tingting Geng, Ning Zhang, Tian Feng, Yajuan Ma, Dongya Yuan & Longli Kang. (2016) Genetic polymorphisms of the drug-metabolizing enzyme CYP2C19 in the Uyghur population in northwest China. Xenobiotica 46:7, pages 634-640.
Read now
Yun-Yun Zhan, Bing-Qing Liang, Hao Wang, Zhen-He Wang, Qing-Hua Weng, Da-Peng Dai, Jian-Ping Cai & Guo-Xin Hu. (2016) Effect of CYP2D6 variants on venlafaxine metabolism in vitro. Xenobiotica 46:5, pages 424-429.
Read now
Hui-dan Zhu, Ni Gu, Meng Wang, Hong-ru Kong & Meng-tao Zhou. (2015) Effects of capsicine on rat cytochrome P450 isoforms CYP1A2, CYP2C19, and CYP3A4. Drug Development and Industrial Pharmacy 41:11, pages 1824-1828.
Read now
Da-Peng Dai, Li-Ming Hu, Pei-Wu Geng, Shuang-Hu Wang, Jie Cai, Guo-Xin Hu & Jian-Ping Cai. (2015) In vitro functional analysis of 24 novel CYP2C19 variants recently found in the Chinese Han population. Xenobiotica 45:11, pages 1030-1035.
Read now
Igor Koturbash, William H Tolleson, Lei Guo, Dianke Yu, Si Chen, Huixiao Hong, William Mattes & Baitang Ning. (2015) Micrornas as Pharmacogenomic Biomarkers for Drug Efficacy and Drug Safety Assessment. Biomarkers in Medicine 9:11, pages 1153-1176.
Read now
Jacob T Brown & Jeffrey R Bishop. (2015) Atomoxetine Pharmacogenetics: Associations with Pharmacokinetics, Treatment Response and Tolerability. Pharmacogenomics 16:13, pages 1513-1520.
Read now
Jin H. Yoon, Scott D. Lane & Michael F. Weaver. (2015) Opioid Analgesics and Nicotine: More Than Blowing Smoke. Journal of Pain & Palliative Care Pharmacotherapy 29:3, pages 281-289.
Read now
Xiaoxiang Du, Huizhou Ye, Chunxia Zhang, Lei Ye & Guanyang Lin. (2015) Effect of kanglaite on rat cytochrome P450. Pharmaceutical Biology 53:7, pages 995-1001.
Read now
Douglas F. Dluzen & Philip Lazarus. (2015) MicroRNA regulation of the major drug-metabolizing enzymes and related transcription factors. Drug Metabolism Reviews 47:3, pages 320-334.
Read now
Ramakrishna Nirogi, Raghava Choudary Palacharla, Venkatesham Uthukam, Arunkumar Manoharan, Surya Rao Srikakolapu, Ilayaraja Kalaikadhiban, Rajesh Kumar Boggavarapu, Ranjith Kumar Ponnamaneni, Devender Reddy Ajjala & Gopinadh Bhyrapuneni. (2015) Chemical inhibitors of CYP450 enzymes in liver microsomes: combining selectivity and unbound fractions to guide selection of appropriate concentration in phenotyping assays. Xenobiotica 45:2, pages 95-106.
Read now
Florence CF Chang & Victor SC Fung. (2014) Clinical significance of pharmacogenomic studies in tardive dyskinesia associated with patients with psychiatric disorders. Pharmacogenomics and Personalized Medicine 7, pages 317-328.
Read now
Marisol López-López, Eva Peñas-Lledó, Pedro Dorado, Alberto Ortega, Teresa Corona, Adriana Ochoa, Petra Yescas, Elisa Alonso & Adrián LLerena. (2014) CYP2D6Genetic Polymorphisms in Southern Mexican Mayan Lacandones and Mestizos from Chiapas. Pharmacogenomics 15:15, pages 1859-1865.
Read now
Yi Huang, Shuang-li Zheng, Zhi-sheng Xu & Yao Hou. (2014) Effects of Alismatis rhizome on rat cytochrome P450 enzymes. Pharmaceutical Biology 52:6, pages 681-687.
Read now
Yu-Han Wang, Pei-Pei Pan, Da-Peng Dai, Shuang-Hu Wang, Pei-Wu Geng, Jian-Ping Cai & Guo-Xin Hu. (2014) Effect of 36 CYP2C9 variants found in the Chinese population on losartan metabolism in vitro. Xenobiotica 44:3, pages 270-275.
Read now
Nadia Aspromonte, Francesco Monitillo, Agata Puzzovivo, Roberto Valle, Pasquale Caldarola & Massimo Iacoviello. (2014) Modulation of cardiac cytochrome P450 in patients with heart failure. Expert Opinion on Drug Metabolism & Toxicology 10:3, pages 327-339.
Read now
Hassan R. Dhaini & Loulou Kobeissi. (2014) Toxicogenetic Profile and Cancer Risk in Lebanese. Journal of Toxicology and Environmental Health, Part B 17:2, pages 95-125.
Read now
Dennie GA Hebels, Marlon JA Jetten, Hugo JW Aerts, Ralf Herwig, Daniël HJ Theunissen, Stan Gaj, Joost H van Delft & Jos CS Kleinjans. (2014) Evaluation of Database-Derived Pathway Development for Enabling Biomarker Discovery for Hepatotoxicity. Biomarkers in Medicine 8:2, pages 185-200.
Read now
Amir S. Youssef, Upendra A. Argikar, Murali Pathikonda, Henry P. Parkman & Swati Nagar. (2013) Identification of domperidone metabolites in plasma and urine of gastroparesis patients with LC–ESI-MS/MS. Xenobiotica 43:12, pages 1073-1083.
Read now
Haruka Nishimuta, Tetsuya Nakagawa, Naruaki Nomura & Masashi Yabuki. (2013) Species differences in hepatic and intestinal metabolic activities for 43 human cytochrome P450 substrates between humans and rats or dogs. Xenobiotica 43:11, pages 948-955.
Read now
Daniel J. Müller, Ivana Kekin, Amy C. C. Kao & Eva J. Brandl. (2013) Towards the implementation of CYP2D6 and CYP2C19 genotypes in clinical practice: Update and report from a pharmacogenetic service clinic. International Review of Psychiatry 25:5, pages 554-571.
Read now
C. Anthony Altar, John Hornberger, Ashwini Shewade, Victor Cruz, Jill Garrison & David Mrazek. (2013) Clinical validity of cytochrome P450 metabolism and serotonin gene variants in psychiatric pharmacotherapy. International Review of Psychiatry 25:5, pages 509-533.
Read now
Maria Konstandi. (2013) Psychophysiological stress: a significant parameter in drug pharmacokinetics. Expert Opinion on Drug Metabolism & Toxicology 9:10, pages 1317-1334.
Read now
Vidya Perera, Annette S Gross, Thomas M Polasek, Yan Qin, Gauri Rao, Alan Forrest, Junzhe Xu & Andrew J McLachlan. (2013) Considering CYP1A2 phenotype and genotype for optimizing the dose of olanzapine in the management of schizophrenia. Expert Opinion on Drug Metabolism & Toxicology 9:9, pages 1115-1137.
Read now
Marco Alessandrini, Sahle Asfaha, Tyren Mark Dodgen, Louise Warnich & Michael Sean Pepper. (2013) Cytochrome P450 pharmacogenetics in African populations. Drug Metabolism Reviews 45:2, pages 253-275.
Read now
Danilo C Finamor, Rita Sinigaglia-Coimbra, Luiz C. M. Neves, Marcia Gutierrez, Jeferson J. Silva, Lucas D. Torres, Fernanda Surano, Domingos J. Neto, Neil F. Novo, Yara Juliano, Antonio C. Lopes & Cicero Galli Coimbra. (2013) A pilot study assessing the effect of prolonged administration of high daily doses of vitamin D on the clinical course of vitiligo and psoriasis. Dermato-Endocrinology 5:1, pages 222-234.
Read now
Saskia J. Rietjens, Laura Hondebrink, Remco H. S. Westerink & Jan Meulenbelt. (2012) Pharmacokinetics and pharmacodynamics of 3,4-methylenedioxymethamphetamine (MDMA): interindividual differences due to polymorphisms and drug–drug interactions. Critical Reviews in Toxicology 42:10, pages 854-876.
Read now
Li-Ming Hu, Da-Peng Dai, Guo-Xin Hu, Jie-Fu Yang, Ren-Ai Xu, Li-Ping Yang, Jian-Chang Qian, Ren-Shan Ge & Jian-Ping Cai. (2012) Genetic Polymorphisms and Novel Allelic Variants of CYP2C19 in the Chinese Han Population. Pharmacogenomics 13:14, pages 1571-1581.
Read now
Xianlu Zhuo, Houyu Zhao, Aoshuang Chang, Yan Zhou, Gang Zhang, Yufeng Song & Yinghui Tan. (2012) Quantitative Assessment of CYP1A1*2A Variations With Oral Carcinoma Susceptibility: Evidence From 1,438 Cases and 2,086 Controls. Cancer Investigation 30:8, pages 552-559.
Read now
Pascal Detampel, Mareike Beck, Stephan Krähenbühl & Jörg Huwyler. (2012) Drug interaction potential of resveratrol. Drug Metabolism Reviews 44:3, pages 253-265.
Read now
Joseph McGraw & Donald Waller. (2012) Cytochrome P450 variations in different ethnic populations. Expert Opinion on Drug Metabolism & Toxicology 8:3, pages 371-382.
Read now
Heather E Wheeler & M Eileen Dolan. (2012) Lymphoblastoid Cell Lines in Pharmacogenomic Discovery and Clinical Translation. Pharmacogenomics 13:1, pages 55-70.
Read now
Jing Li & Martin H Bluth. (2011) Pharmacogenomics of drug metabolizing enzymes and transporters: implications for cancer therapy. Pharmacogenomics and Personalized Medicine 4, pages 11-33.
Read now
Martin Schwaiblmair, Werner Behr, Wolfgang Foerg & Thomas Berghaus. (2011) Cytochrome P450 polymorphisms and drug-induced interstitial lung disease. Expert Opinion on Drug Metabolism & Toxicology 7:12, pages 1547-1560.
Read now
Kristin M. Fabre, Keita Saito, William G. DeGraff, Anastasia L. Sowers, Angela Thetford, John A. Cook, Murali C. Krishna & James B. Mitchell. (2011) The effects of resveratrol and selected metabolites on the radiation and antioxidant response. Cancer Biology & Therapy 12:10, pages 915-923.
Read now
Paul O Gubbins. (2011) Triazole antifungal agents drug–drug interactions involving hepatic cytochrome P450. Expert Opinion on Drug Metabolism & Toxicology 7:11, pages 1411-1429.
Read now
Leposava Antonovic & Marilyn Martinez. (2011) Role of the Cytochrome P450 Enzyme System in Veterinary Pharmacokinetics: Where are We Now? Where are We Going?. Future Medicinal Chemistry 3:7, pages 855-879.
Read now
Ya-He Liu, Sui-Lin Mo, Hui-Chang Bi, Bing-Fang Hu, Chun Guang Li, Yi-Tao Wang, Ling Huang, Min Huang, Wei Duan, Jun-Ping Liu, Ming Qian Wei & Shu-Feng Zhou. (2011) Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study. Xenobiotica 41:4, pages 259-280.
Read now
Markus R Meyer & Hans H Maurer. (2011) Absorption, Distribution, Metabolism and Excretion Pharmacogenomics of Drugs of Abuse. Pharmacogenomics 12:2, pages 215-233.
Read now
Alice I Nichols, Karen A Tourian, Susanna Y Tse & Jeffrey Paul. (2010) Desvenlafaxine for major depressive disorder: incremental clinical benefits from a second-generation serotonin–norepinephrine reuptake inhibitor. Expert Opinion on Drug Metabolism & Toxicology 6:12, pages 1565-1574.
Read now
Elizabeth A Shephard & Ian R Phillips. (2010) The potential of knockout mouse lines in defining the role of flavin-containing monooxygenases in drug metabolism. Expert Opinion on Drug Metabolism & Toxicology 6:9, pages 1083-1094.
Read now
Shu-Feng Zhou, Bo Wang, Li-Ping Yang & Jun-Ping Liu. (2010) Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2. Drug Metabolism Reviews 42:2, pages 268-354.
Read now
Alex J. Rai, Jessica Yee & Martin Fleisher. (2010) Biomarkers in the era of personalized medicine – a multiplexed SNP assay using capillary electrophoresis for assessing drug metabolism capacity. Scandinavian Journal of Clinical and Laboratory Investigation 70:sup242, pages 15-18.
Read now
Bo Wang, Li-Ping Yang, Xiao-Zhuang Zhang, Shui-Qing Huang, Mark Bartlam & Shu-Feng Zhou. (2009) New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme. Drug Metabolism Reviews 41:4, pages 573-643.
Read now
Simona De gregori, Manuela De Gregori, Guglielmina Nadia Ranzani, Alessandro Borghesi, Mario Regazzi & Mauro Stronati. (2009) Drug transporters and renal drug disposition in the newborn. The Journal of Maternal-Fetal & Neonatal Medicine 22:sup3, pages 31-37.
Read now

Articles from other publishers (501)

Isabel S. Barata, José Rueff, Michel Kranendonk & Francisco Esteves. (2024) Pleiotropy of Progesterone Receptor Membrane Component 1 in Modulation of Cytochrome P450 Activity. Journal of Xenobiotics 14:2, pages 575-603.
Crossref
Christina Abdel Shaheed, Christopher Hayes, Christopher G. Maher, Jane C. Ballantyne, Martin Underwood, Andrew J. McLachlan, Jennifer H. Martin, Sujita W. Narayan & Mark A. Sidhom. (2023) Opioid analgesics for nociceptive cancer pain: A comprehensive review. CA: A Cancer Journal for Clinicians 74:3, pages 286-313.
Crossref
Anne Vonada, Leslie Wakefield, Michael Martinez, Cary O. Harding, Markus Grompe & Amita Tiyaboonchai. (2024) Complete correction of murine phenylketonuria by selection-enhanced hepatocyte transplantation. Hepatology 79:5, pages 1088-1097.
Crossref
Xiaoyu Men, Zachary L. Taylor, Victoria S. Marshe, Daniel M. Blumberger, Jordan F. Karp, James L. Kennedy, Eric J. Lenze, Charles F. ReynoldsIIIIII, Cristiana Stefan, Benoit H. Mulsant, Laura B. Ramsey & Daniel J. Müller. (2024) CYP2D6 Phenotype Influences Pharmacokinetic Parameters of Venlafaxine: Results from a Population Pharmacokinetic Model in Older Adults with Depression . Clinical Pharmacology & Therapeutics 115:5, pages 1065-1074.
Crossref
Lixuan Qian, Jessica L. Beers, Klarissa D. Jackson & Zhu Zhou. (2024) CBD and THC in Special Populations: Pharmacokinetics and Drug–Drug Interactions. Pharmaceutics 16:4, pages 484.
Crossref
Alba Alonso Llorente, Josefa Salgado Garrido, Óscar Teijido Hermida, Fabricio González Andrade, Alberto Valiente Martín, Ana Julia Fanlo Villacampa & Jorge Vicente Romero. (2024) Genetic polymorphisms of CYP2C19 in ecuadorian population: An interethnic approach. Heliyon 10:7, pages e28566.
Crossref
James M. Harris, Andrea Magri, Ana Rita Faria, Senko Tsukuda, Peter Balfe, Peter A.C. Wing & Jane A. McKeating. (2024) Oxygen-dependent histone lysine demethylase 4 restricts hepatitis B virus replication. Journal of Biological Chemistry 300:3, pages 105724.
Crossref
Revati Varma, Jeffrey P. Staab, Eric T. Matey, Jessica A. Wright, Brototo Deb, Konstantinos N. Lazaridis, Lawrence A. Szarka, Kent R. Bailey & Adil E. Bharucha. (2023) Most patients with disorders of gut‐brain interaction receive pharmacotherapy with major or moderate drug‐gene interactions. Neurogastroenterology & Motility 36:2.
Crossref
Natalia Guevara, Marta Vázquez & Pietro Fagiolino. 2024. Encyclopedia of Toxicology. Encyclopedia of Toxicology 161 179 .
Matías F. Martínez & Luis A. Quiñones. 2024. ADME Processes in Pharmaceutical Sciences. ADME Processes in Pharmaceutical Sciences 367 400 .
Mojtaba Oraki Kohshour, Nora I. Strom, Sandra Melanie Meier, Francis J. McMahon, Kathleen R. Merikangas, Thomas G. Schulze & Manuel Mattheisen. 2020. Tasman’s Psychiatry. Tasman’s Psychiatry 1 26 .
Su Min Kim, So Young Jo, Ho-Young Park, Yu Ra Lee, Jun Sang Yu & Hye Hyun Yoo. (2023) Investigation of Drug-Interaction Potential for Arthritis Dietary Supplements: Chondroitin Sulfate, Glucosamine, and Methylsulfonylmethane. Molecules 28:24, pages 8068.
Crossref
Shiori Takeji, Mai Okada, Shu Hayashi, Kengo Kanamaru, Yuichi Uno, Hiromasa Imaishi & Tomohide Uno. (2023) Metabolism of testosterone and progesterone by cytochrome P450 2C19 allelic variants. Biopharmaceutics & Drug Disposition 44:6, pages 420-430.
Crossref
Kavindi Jayawickreme, Dawid Świstak, Ewa Ozimek, Emilia Reszczyńska, Anna Rysiak, Anna Makuch-Kocka & Agnieszka Hanaka. (2023) Pyrrolizidine Alkaloids—Pros and Cons for Pharmaceutical and Medical Applications. International Journal of Molecular Sciences 24:23, pages 16972.
Crossref
Sai-li Xie, Xiayan Zhu, Nanyong Gao, Qianmeng Lin, Chaojie Chen, Yun-jun Yang, Jian-ping Cai, Guo-xin Hu & Ren-ai Xu. (2023) Genetic variations of CYP3A4 on the metabolism of itraconazole in vitro. Food and Chemical Toxicology 181, pages 114101.
Crossref
Mona Saad, Rongxin Zhang, Anne Cucchiarini, Cybel Mehawej, Jean-Louis Mergny, Mohamad Mroueh & Wissam H. Faour. (2023) G-quadruplex forming sequences in the genes coding for cytochrome P450 enzymes and their potential roles in drug metabolism. Biochimie 214, pages 45-56.
Crossref
Jessica MeulmanMarília Berlofa Visacri, Patricia MorielEder de Carvalho Pincinato. (2023) Influence of Genetic Polymorphisms on the Pharmacokinetics of Trazodone Hydrochloride: A Scoping Review and Future Perspective. Therapeutic Drug Monitoring 45:4, pages 479-486.
Crossref
Amelia Nathania Dong, Nafees Ahemad, Yan Pan, Uma Devi Palanisamy & Chin Eng Ong. (2023) Interactions of coumarin and amine ligands with six cytochrome P450 2D6 allelic variants: Molecular docking. Computational Toxicology 27, pages 100284.
Crossref
Isabel Tamargo-Rubio, Anna Bella Simpson, Joanne A. Hoogerland & Jingyuan Fu. (2023) Human induced pluripotent stem cell–derived liver-on-a-chip for studying drug metabolism: the challenge of the cytochrome P450 family. Frontiers in Pharmacology 14.
Crossref
Maria Konstandi & Elizabeth O. Johnson. (2023) Age-related modifications in CYP-dependent drug metabolism: role of stress. Frontiers in Endocrinology 14.
Crossref
Pureum Kang, Chang-Keun Cho, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee, Chang-Ik Choi & Jung-Woo Bae. (2023) Effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of gliclazide in healthy subjects. Archives of Pharmacal Research 46:5, pages 438-447.
Crossref
Tridib Chaira, Chandru Subramani & Tarani Kanta Barman. (2023) ADME, Pharmacokinetic Scaling, Pharmacodynamic and Prediction of Human Dose and Regimen of Novel Antiviral Drugs. Pharmaceutics 15:4, pages 1212.
Crossref
Seongkuk Hong & Jung-Woo Bae. (2023) Frequency of the CYP2C19 *10 Allele in the Korean Population . Drug Targets and Therapeutics 2:1, pages 12-18.
Crossref
Artitaya Thiengsusuk, Tullayakorn Plengsuriyakarn & Kesara Na-Bangchang. (2023) Modulatory Effects of Atractylodin and β-Eudesmol on Human Cytochrome P450 Enzymes: Potential Drug-Drug Interactions. Molecules 28:7, pages 3140.
Crossref
Mei-Juan Tu & Ai-Ming Yu. (2023) Recent Advances in Novel Recombinant RNAs for Studying Post-transcriptional Gene Regulation in Drug Metabolism and Disposition. Current Drug Metabolism 24:3, pages 175-189.
Crossref
Frédérique Rodieux, Youssef Daali, Victoria Rollason, Caroline F. Samer & Kuntheavy Ing Lorenzini. (2023) Practice of CYP450 genotyping and phenotyping in children in a real-life setting. Frontiers in Pharmacology 14.
Crossref
Chiratidzo R. Chamboko, Wayde Veldman, Rolland Bantar Tata, Birgit Schoeberl & Özlem Tastan Bishop. (2023) Human Cytochrome P450 1, 2, 3 Families as Pharmacogenes with Emphases on Their Antimalarial and Antituberculosis Drugs and Prevalent African Alleles. International Journal of Molecular Sciences 24:4, pages 3383.
Crossref
Hu Li, Pengbo Hu, Yajun Zou, Lijuan Yuan, Yucheng Xu, Xiaohui Zhang, Xiaoyan Luo & Zhiqiang Zhang. (2023) Tanshinone IIA and hepatocellular carcinoma: A potential therapeutic drug. Frontiers in Oncology 13.
Crossref
Di Fu, Hong-Li Guo, Ya-Hui Hu, Wei-Rong Fang, Qian-Qi Liu, Jing Xu, Dan-Dan Wu & Feng Chen. (2023) Personalizing atomoxetine dosing in children with ADHD: what can we learn from current supporting evidence. European Journal of Clinical Pharmacology.
Crossref
Manon C. Bouwmeester, Yu Tao, Susana Proença, Frank G. van Steenbeek, Roos-Anne Samsom, Sandra M. Nijmeijer, Theo Sinnige, Luc J. W. van der Laan, Juliette Legler, Kerstin Schneeberger, Nynke I. Kramer & Bart Spee. (2023) Drug Metabolism of Hepatocyte-like Organoids and Their Applicability in In Vitro Toxicity Testing. Molecules 28:2, pages 621.
Crossref
TIRTHA NANDI. (2023) IMPORTANCE OF SUFFICIENT TIME POINTS FOR EFFICIENT PHARMACOKINETIC (PK) COMPARTMENTAL MODELING. International Journal of Applied Pharmaceutics, pages 87-92.
Crossref
Adrijana Kekic. 2023. Pharmacogenomics in Clinical Practice. Pharmacogenomics in Clinical Practice 147 185 .
Nada Sabourdin, Nicolas Louvet & Isabelle Constant. 2023. Neonatal Anesthesia. Neonatal Anesthesia 167 187 .
Orphélie Lootens, An Vermeulen, Siska Croubels, Sarah De Saeger, Jan Van Bocxlaer & Marthe De Boevre. (2022) Possible Mechanisms of the Interplay between Drugs and Mycotoxins—Is There a Possible Impact?. Toxins 14:12, pages 873.
Crossref
Fang-Ling Zhao, Qing Zhang, Shuang-Hu Wang, Yun Hong, Shan Zhou, Quan Zhou, Pei-Wu Geng, Qing-Feng Luo, Jie-Fu Yang, Hao Chen, Jian-Ping Cai & Da-Peng Dai. (2022) Identification and drug metabolic characterization of four new CYP2C9 variants CYP2C9*72-*75 in the Chinese Han population. Frontiers in Pharmacology 13.
Crossref
Jin Zhou, Xian Qian, Yanqing Zhou, Shili Xiong, Shuxia Ji, Ying Wang & Ping Zhao. (2022) Human liver microsomes study on the inhibitory effect of plantainoside D on the activity of cytochrome P450 activity. BMC Complementary Medicine and Therapies 22:1.
Crossref
Yitian Zhou & Volker M. Lauschke. (2022) The genetic landscape of major drug metabolizing cytochrome P450 genes—an updated analysis of population-scale sequencing data. The Pharmacogenomics Journal 22:5-6, pages 284-293.
Crossref
Yiting He, Haobin Cen, Lianxia Guo, Tianpeng Zhang, Yi Yang, Dong Dong & Baojian Wu. (2022) Circadian oscillator NPAS2 regulates diurnal expression and activity of CYP1A2 in mouse liver. Biochemical Pharmacology 206, pages 115345.
Crossref
Clément Delage, Léa Darnaud, Bruno Etain, Marina Vignes, Tu-Ky Ly, Alexia Frapsauce, Marc Veyrier, Marine Delavest, Emeline Marlinge, Vincent Hennion, Manon Meyrel, Aude Jacob, Margot Chouchana, Julie Smati, Guillaume Pataud, Nihel Khoudour, Jean-Eudes Fontan, Laurence Labat, Frank Bellivier, Célia Lloret-Linares, Xavier Declèves & Vanessa Bloch. (2022) Cytochromes P450 and P-Glycoprotein Phenotypic Assessment to Optimize Psychotropic Pharmacotherapy: A Retrospective Analysis of Four Years of Practice in Psychiatry. Journal of Personalized Medicine 12:11, pages 1869.
Crossref
Vladimir Mishin, Diane E. Heck, Yi-Hua Jan, Jason R. Richardson & Jeffrey D. Laskin. (2022) Distinct effects of form selective cytochrome P450 inhibitors on cytochrome P450-mediated monooxygenase and hydrogen peroxide generating NADPH oxidase. Toxicology and Applied Pharmacology 455, pages 116258.
Crossref
Sumiko Ohnami, Akane Naruoka, Mitsuhiro Isaka, Maki Mizuguchi, Sou Nakatani, Fukumi Kamada, Yuji Shimoda, Ai Sakai, Keiichi Ohshima, Keiichi Hatakeyama, Kouji Maruyama, Yasuhisa Ohde, Hirotsugu Kenmotsu, Toshiaki Takahashi, Yasuto Akiyama, Takeshi Nagashima, Kenichi Urakami, Shumpei Ohnami & Ken Yamaguchi. (2022) Comparison of genetic susceptibility to lung adenocarcinoma and squamous cell carcinoma in Japanese patients using a novel panel for cancer-related drug-metabolizing enzyme genes. Scientific Reports 12:1.
Crossref
Marios Spanakis, Evridiki Patelarou & Athina Patelarou. (2022) Drug-Food Interactions with a Focus on Mediterranean Diet. Applied Sciences 12:20, pages 10207.
Crossref
Zhuolin Zhang, Yuwen Bao, Lele Cai, Yajie Gu, Ting Yang & Xin Li. (2022) Cost-Utility Analysis of CYP2C19 Genotype Detection for Selection of Acid-Suppressive Therapy with Lansoprazole or Vonoprazan for Patients with Reflux Esophagitis in China. Clinical Drug Investigation 42:10, pages 839-851.
Crossref
Ahizechukwu C. Eke. (2022) An update on the physiologic changes during pregnancy and their impact on drug pharmacokinetics and pharmacogenomics. Journal of Basic and Clinical Physiology and Pharmacology 33:5, pages 581-598.
Crossref
Zhize Ye, Bingbing Chen, Nanyong Gao, Qihui Kong, Xiaoqin Hu, Zhongqiu Lu, Jianchang Qian, Guoxin Hu, Jianping Cai & Bin Wu. (2022) CYP2D6 gene polymorphism and apatinib affect the metabolic profile of fluvoxamine. Frontiers in Pharmacology 13.
Crossref
Kristin N Grimsrud, Ryan R Davis, Clifford G Tepper & Tina L Palmieri. (2022) Pharmacogenetic Gene–Drug Associations in Pediatric Burn and Surgery Patients. Journal of Burn Care & Research 43:5, pages 987-996.
Crossref
Cavan McCaffery, Hanwei Zhu, C.M. Sabbir Ahmed, Alexa Canchola, Jin Y. Chen, Chengguo Li, Kent C. Johnson, Thomas D. Durbin, Ying-Hsuan Lin & Georgios Karavalakis. (2022) Effects of hydrogenated vegetable oil (HVO) and HVO/biodiesel blends on the physicochemical and toxicological properties of emissions from an off-road heavy-duty diesel engine. Fuel 323, pages 124283.
Crossref
Orphélie Lootens, Marthe De Boevre, Elke Gasthuys, Jan Van Bocxlaer, An Vermeulen & Sarah De Saeger. (2022) Unravelling the pharmacokinetics of aflatoxin B1: In vitro determination of Michaelis–Menten constants, intrinsic clearance and the metabolic contribution of CYP1A2 and CYP3A4 in pooled human liver microsomes. Frontiers in Microbiology 13.
Crossref
Megan Leigh Hutchcraft, Shulin Zhang, Nan Lin, Ginny Lee Gottschalk, James W. Keck, Elizabeth A. Belcher, Catherine Sears, Chi Wang, Kun Liu, Lauren E. Dietz, Justine C. Pickarski, Sainan Wei, Roberto Cardarelli, Robert S. DiPaola & Jill M. Kolesar. (2022) Real-World Evaluation of a Population Germline Genetic Screening Initiative for Family Medicine Patients. Journal of Personalized Medicine 12:8, pages 1297.
Crossref
Deepak Ahire, Laken Kruger, Sheena Sharma, Vijaya Saradhi Mettu, Abdul Basit & Bhagwat Prasad. (2022) Quantitative Proteomics in Translational Absorption, Distribution, Metabolism, and Excretion and Precision Medicine. Pharmacological Reviews 74:3, pages 771-798.
Crossref
Mohammad Kamely, Mohammad Amir Karimi Torshizi, James West & Theo Niewold. (2021) Impacts of caffeine on resistant chicken's performance and cardiovascular gene expression. Journal of Animal Physiology and Animal Nutrition 106:3, pages 566-574.
Crossref
Chuang-Wei Wang, Ivan Arni C. Preclaro, Wei-Hsiang Lin & Wen-Hung Chung. (2022) An Updated Review of Genetic Associations With Severe Adverse Drug Reactions: Translation and Implementation of Pharmacogenomic Testing in Clinical Practice. Frontiers in Pharmacology 13.
Crossref
A. C. Pronk, L. J. Seppala, K. Trajanoska, N. Stringa, B. van de Loo, L. C. P. G. M. de Groot, N. M. van Schoor, F. Koskeridis, G. Markozannes, E. Ntzani, A. G. Uitterlinden, F. Rivadeneira, B. H. Stricker & N. van der Velde. (2022) Candidate genetic variants and antidepressant-related fall risk in middle-aged and older adults. PLOS ONE 17:4, pages e0266590.
Crossref
Jacob P. Sorrentino & Ryan A. Altman. (2022) Fluoroalkylation of Dextromethorphan Improves CNS Exposure and Metabolic Stability. ACS Medicinal Chemistry Letters 13:4, pages 707-713.
Crossref
Vikas Parihar, Annarita Rogers, Allison Marie Blain, Samuel Ramesh Kumar Zacharias, Lisa Laureen Patterson & Mahmoud Abdel-Magid Siyam. (2020) Reduction in Tamoxifen Metabolites Endoxifen and N-desmethyltamoxifen With Chronic Administration of Low Dose Cannabidiol: A CYP3A4 and CYP2D6 Drug Interaction. Journal of Pharmacy Practice 35:2, pages 322-326.
Crossref
Hossein Dehdari, Fatemeh Moradian, Ali Barzegar & Mohammad Ali Ebrahimzadeh. (2022) CYP1A1 contiguous hypermethylation within a putative CpG block is associated with breast cancer progression: Feasibility to define boundary motives. Experimental Cell Research 413:1, pages 113062.
Crossref
Korlan Z. Saduakassova & Gulnara S. Svyatova. (2022) RETRACTED: Population features of alleles and genotypes frequency distribution of polymorphic genetic markers of antipsychotic medications pharmacokinetics in the Kazakh population. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 189:3-4, pages 100-107.
Crossref
Maria Konstandi, Elizabeth O. Johnson & Matti A. Lang. (2022) Stress as a Potential Regulatory Factor in the Outcome of Pharmacotherapy. Frontiers in Neuroscience 16.
Crossref
Kit-Kay Mak, Ola Epemolu & Mallikarjuna Rao Pichika. (2022) The role of DMPK science in improving pharmaceutical research and development efficiency. Drug Discovery Today 27:3, pages 705-729.
Crossref
Ling-jing Yuan, Jian-chang Qian, Xiang-yu Li, Ju Cui, Jian-ping Cai & Guo-xin Hu. (2022) Enzymatic activity on valsartan of 38 CYP2C9 variants from the Chinese population. Chemico-Biological Interactions 353, pages 109799.
Crossref
Dongmei Chen, Qiqi Fan, Ting Xu, Jinyun Dong, Jiahua Cui, Zengtao Wang, Jie Wang, Qingqing Meng & Shaoshun Li. (2022) Design, Synthesis and Binding Affinity Evaluation of Cytochrome P450 1B1 Targeted Chelators. Anti-Cancer Agents in Medicinal Chemistry 22:2, pages 261-269.
Crossref
Ryan James McGinn, Erica Leah Von Stein, Jacqueline Elizabeth Summers Stromberg & Yi Li. 2022. Precision Medicine. Precision Medicine 147 188 .
Magnus Ingelman-Sundberg. 2022. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary. Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary 393 416 .
Yusra Habib Khan, Nida Bokharee, Maria Rasheed, Amna Saifullah, Aisha Khokhar, Safia Akhtar Khan, Amjad Khan & Tauqeer Hussain Mallhi. 2022. Biochemistry of Drug Metabolizing Enzymes. Biochemistry of Drug Metabolizing Enzymes 141 159 .
Rahat Andleeb, Aliza Mazhar, Shabana Naz, Tajammul Hussain, Derya Karataş Yeni & Asma Ashraf. 2022. Biochemistry of Drug Metabolizing Enzymes. Biochemistry of Drug Metabolizing Enzymes 161 190 .
Mariamena Arbitrio, Francesca Scionti, Maria Teresa Di Martino, Licia Pensabene, Pierfrancesco Tassone & Pierosandro Tagliaferri. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 657 697 .
Evangelia Eirini Tsermpini, Tea Terzi, Blanka Kores Plesničar & Vita Dolžan. 2022. Psychiatric Genomics. Psychiatric Genomics 161 188 .
James Akingbasote, Sandra Szlapinski, Elora Hilmas, Patrik Miller & Natalie Rine. 2022. Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology. Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology 197 232 .
Matías F. Martínez, Leslie C. Cerpa, Nelson M. Varela & Luis A. Quiñones. 2022. The ADME Encyclopedia. The ADME Encyclopedia 899 907 .
Nguyen Thi Thu Phuong, Nguyen Thanh Hoi & Jae-Gook Shin. 2022. 8th International Conference on the Development of Biomedical Engineering in Vietnam. 8th International Conference on the Development of Biomedical Engineering in Vietnam 553 567 .
Eleonora Pozzi & Paola Alberti. 2022. Pharmacogenomics in Drug Discovery and Development. Pharmacogenomics in Drug Discovery and Development 95 140 .
Aino L. Andersen, Morten B. Houlind, Rikke L. Nielsen, Lillian M. Jørgensen, Charlotte Treldal, Morten Damgaard, Anne Kathrine Bengaard, Helle Gybel Juul-Larsen, Louise Bolvig Laursen, Esben Iversen, Marie Kruse, Anne M. L. Pedersen, Mads Hornum, Anne M. Beck, Mette M. Pedersen, Mikkel Z. Ankarfeldt, Janne Petersen & Ove Andersen. (2021) Optimization of Nutrition And Medication (OptiNAM) for acutely admitted older patients: protocol for a randomized single-blinded controlled trial. Trials 22:1.
Crossref
Xiujuan Zhang, Xiaole Song, Yuting Lai, Bijun Zhu, Jiqin Luo, Hongmeng Yu & Yiqun Yu. (2021) Identification of key pseudogenes in nasopharyngeal carcinoma based on RNA-Seq analysis. BMC Cancer 21:1.
Crossref
Kazuya Maeda, Akihiro Hisaka, Kiyomi Ito, Yoshiyuki Ohno, Akihiro Ishiguro, Reiko Sato & Naomi Nagai. (2021) Classification of drugs for evaluating drug interaction in drug development and clinical management. Drug Metabolism and Pharmacokinetics 41, pages 100414.
Crossref
Mingming Han, Xiaodan Zhang, Zhize Ye, Jing Wang, Jianchang Qian, Guoxin Hu & Jianping Cai. (2021) Functional evaluation of vandetanib metabolism by CYP3A4 variants and potential drug interactions in vitro. Chemico-Biological Interactions 350, pages 109700.
Crossref
Shalini Roy Chowdhury, Oindrilla Dutta Gupta, Arnab Kumar Ghosh, Partha Sarathi Singha, Syed Benazir Firdaus & Klaus Klarskov. (2021) Genetic variations and epigenetic modulations in CYP genes: Implications in NSAID-treatment of arthritis patients. The Nucleus 64:3, pages 331-342.
Crossref
Manon C. Bouwmeester, Paulina N. Bernal, Loes A. Oosterhoff, Monique E. van Wolferen, Vivian Lehmann, Monique Vermaas, Maj‐Britt Buchholz, Quentin C. Peiffer, Jos Malda, Luc J. W. van der Laan, Nynke I. Kramer, Kerstin Schneeberger, Riccardo Levato & Bart Spee. (2021) Bioprinting of Human Liver‐Derived Epithelial Organoids for Toxicity Studies. Macromolecular Bioscience 21:12.
Crossref
Kenza Abouir, Caroline F Samer, Yvonne Gloor, Jules A Desmeules & Youssef Daali. (2021) Reviewing Data Integrated for PBPK Model Development to Predict Metabolic Drug-Drug Interactions: Shifting Perspectives and Emerging Trends. Frontiers in Pharmacology 12.
Crossref
Xiaobo Li, Jiaoting Hu, Yueming Yuan, Yunhan Wang, Zheng Yuan, Ruidong Liu, Shouya Zhang, Zhiyong Xu, Qi Wang, Qin Xu, Li Ru & Jianping Song. (2021) Pharmacokinetics and Toxicokinetics of Artemisinin-Hydroxychloroquine Sulfate Tablets in Rats and Dogs. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-12.
Crossref
Marco Pinna, Mirko Manchia, Claudia Pisanu, Federica Pinna, Pasquale Paribello, Andrea Carta, Anna Meloni, Claudio Conversano, Maria Del Zompo, Francesco Mola, Alessio Squassina & Bernardo Carpiniello. (2021) Protocol for a pharmacogenetic study of antidepressants: characterization of drug-metabolizing profiles of cytochromes CYP2D6 and CYP2C19 in a Sardinian population of patients with major depressive disorder. Psychiatric Genetics 31:5, pages 186-193.
Crossref
Soraya V. Ganesh, Lianne BeunkBojan Nikolik, Jan van der WeidePierre M. Bet. (2021) Therapeutic Drug Monitoring of Psychotropics as a Diagnostic Tool for CYP2D6 Poor Metabolizer Phenotype. Therapeutic Drug Monitoring 43:5, pages 672-680.
Crossref
Liang Wu, An Kang, Xiaoliang Jin, Yuqing Bao, Peng Miao, Tingmei Lv & Zhu Zhou. (2021) Ilexsaponin A1: In vitro metabolites identification and evaluation of inhibitory drug-drug interactions. Drug Metabolism and Pharmacokinetics 40, pages 100415.
Crossref
Hannah C. Huff, Archit Vasan, Pritam Roy, Aayush Kaul, Emad Tajkhorshid & Aditi Das. (2021) Differential Interactions of Selected Phytocannabinoids with Human CYP2D6 Polymorphisms. Biochemistry 60:37, pages 2749-2760.
Crossref
Bridgette M. Cumming, Zainab Baig, Kelvin W. Addicott, Dongquan Chen & Adrie J. C. Steyn. (2021) Host Bioenergetic Parameters Reveal Cytotoxicity of Antituberculosis Drugs Undetected Using Conventional Viability Assays. Antimicrobial Agents and Chemotherapy 65:10.
Crossref
Roua Gabriela Popescu, Sorin Avramescu, Daniela Eliza Marin, Ionelia Țăranu, Sergiu Emil Georgescu & Anca Dinischiotu. (2021) The Reduction of the Combined Effects of Aflatoxin and Ochratoxin A in Piglet Livers and Kidneys by Dietary Antioxidants. Toxins 13:9, pages 648.
Crossref
Cheng‐Shoong Chong, Vachiranee Limviphuvadh & Sebastian Maurer‐Stroh. (2021) Global spectrum of population‐specific common missense variation in cytochrome P450 pharmacogenes. Human Mutation 42:9, pages 1107-1123.
Crossref
Line Skute Bråten, Tore Haslemo, Marin M. Jukic, Maxim Ivanov, Magnus Ingelman‐Sundberg, Espen Molden & Marianne Kristiansen Kringen. (2021) A Novel CYP2C‐Haplotype Associated With Ultrarapid Metabolism of Escitalopram. Clinical Pharmacology & Therapeutics 110:3, pages 786-793.
Crossref
Antonia F. Stepan & R. Scott Obach. 2021. The Medicinal Chemist's Guide to Solving ADMET Challenges. The Medicinal Chemist's Guide to Solving ADMET Challenges 173 197 .
Andrea Perrelli & Saverio Francesco Retta. (2021) Polymorphisms in genes related to oxidative stress and inflammation: Emerging links with the pathogenesis and severity of Cerebral Cavernous Malformation disease. Free Radical Biology and Medicine 172, pages 403-417.
Crossref
Daniela Fanni, Federica Pinna, Clara Gerosa, Pasquale Paribello, Bernardo Carpiniello, Gavino Faa & Mirko Manchia. (2021) Anatomical distribution and expression of CYP in humans: Neuropharmacological implications . Drug Development Research 82:5, pages 628-667.
Crossref
Masaki Kumondai, Evelyn Gutiérrez Rico, Eiji Hishinuma, Yuya Nakanishi, Shuki Yamazaki, Akiko Ueda, Sakae Saito, Shu Tadaka, Kengo Kinoshita, Daisuke Saigusa, Tomoki Nakayoshi, Akifumi Oda, Noriyasu Hirasawa & Masahiro Hiratsuka. (2021) Functional Characterization of 21 Rare Allelic CYP1A2 Variants Identified in a Population of 4773 Japanese Individuals by Assessing Phenacetin O-Deethylation. Journal of Personalized Medicine 11:8, pages 690.
Crossref
Yoon-A Park, Yu-bin Song, Jeong Yee, Ha-Young Yoon & Hye-Sun Gwak. (2021) Influence of CYP2C9 Genetic Polymorphisms on the Pharmacokinetics of Losartan and Its Active Metabolite E-3174: A Systematic Review and Meta-Analysis. Journal of Personalized Medicine 11:7, pages 617.
Crossref
Shaden HADDAD. (2021) CYP1A1* 2 A gene polymorphism frequency in Syrian breast cancer patients. Meta Gene 28, pages 100861.
Crossref
Sara Sadat Aghabozorg Afjeh, Behzad Boshehri, Safar Hamednia, Asmaolhosna Amini, Parisa Mashayekhi & Mir Davood Omrani. (2021) Investigating the CYP2B6 rs3745274 and rs3211371 polymorphisms in Methadone-Responder and Non-Responder Addicts in Iran. Iranian Biomedical Journal 25:3, pages 220-225.
Crossref
Ren-ai Xu, Shunbin Luo, Qianmeng Lin, Yuanyuan Shao, Chaojie Chen & Xuemei Ye. (2021) Inhibitory effect of propafenone on vortioxetine metabolism in vitro and in vivo. Arabian Journal of Chemistry 14:5, pages 103136.
Crossref
Yurong Song, Chenxi Li, Guangzhi Liu, Rui Liu, Youwen Chen, Wen Li, Zhiwen Cao, Baosheng Zhao, Cheng Lu & Yuanyan Liu. (2021) Drug-Metabolizing Cytochrome P450 Enzymes Have Multifarious Influences on Treatment Outcomes. Clinical Pharmacokinetics 60:5, pages 585-601.
Crossref
Marilyn N. Martinez, Jonathan P. Mochel, Sibylle Neuhoff & Devendra Pade. (2021) Comparison of Canine and Human Physiological Factors: Understanding Interspecies Differences that Impact Drug Pharmacokinetics. The AAPS Journal 23:3.
Crossref
М. М. Юнусбаева, Л. Я. Бородина, Ф. С. Билалов, Р. А. Шарипов & Б. Б. Юнусбаев. (2021) Исследование влияния полиморфизма генов <i>CYP3A5</i>, <i>CYP2B6</i> и <i>NAT2</i> на эффективность лечения туберкулёза с множественной лекарственной устойчивостью. Pharmacogenetics and Pharmacogenomics:2, pages 26-27.
Crossref
Navid Neyshaburinezhad, Mohammadreza Rouini, Hoda Lavasani & Yalda H. Ardakani. (2021) Evaluation of Cinnamon (Cinnamomum Verum) Effects on Liver CYP450 2D1 Activity and Hepatic Clearance in Diabetic Rats. Jundishapur Journal of Natural Pharmaceutical Products 16:1.
Crossref
Xiaofei Wang, Luman Wei, Jingke Yang, Yiting Wang, Shitong Chen, Kun Yang, Xiangguang Meng & Lirong Zhang. (2020) DNA methylation determines the regulation of pregnane X receptor on CYP3A4 expression . Clinical and Experimental Pharmacology and Physiology 48:2, pages 250-259.
Crossref
Yusuf Oloruntoyin Ayipo, Mohd Nizam Mordi, Muzaimi Mustapha & Thenmoly Damodaran. (2021) Neuropharmacological potentials of β-carboline alkaloids for neuropsychiatric disorders. European Journal of Pharmacology 893, pages 173837.
Crossref
Chenming Sheng, Xiaoyan Shi, Zexian Ding, Yunna Chen, Xiaoqian Shi, Yifan Wu, Wenjing Zhang & Weidong Chen. (2021) Effects of mulberry leaf extracts on activity and mRNA expression of five cytochrome P450 enzymes in rat. Brazilian Journal of Pharmaceutical Sciences 57.
Crossref
Sebastian Medina, Xixi Zhou, Fredine T. Lauer, Haikun Zhang, Ke Jian Liu, Johnnye Lewis & Scott W. Burchiel. (2021) Modulation of PARP activity by Monomethylarsonous (MMA+3) acid and uranium in mouse thymus. Toxicology and Applied Pharmacology 411, pages 115362.
Crossref
William C. Schaffenburg, Benjamin N. Lockshin & Cynthia M.C. DeKlotz. 2021. Comprehensive Dermatologic Drug Therapy. Comprehensive Dermatologic Drug Therapy 21 33.e2 .
Tobias Speare, Alice Gilbert, Marcus Tabart & Danny Tsai. 2021. Handbook of Rural, Remote, and very Remote Mental Health. Handbook of Rural, Remote, and very Remote Mental Health 557 578 .
Vesna Jelic & Bengt Winblad. 2021. Management of Patients with Dementia. Management of Patients with Dementia 73 104 .
Matías M. Martínez, Leslie C. Cerpa, Nelson M. Varela & Luis A. Quiñones. 2021. The ADME Encyclopedia. The ADME Encyclopedia 1 9 .
Kevin M. Johnson, Dian Su & Donglu Zhang. 2021. Cytochrome P450. Cytochrome P450 27 54 .
Yu Jin Kim, Maira Soto, Gregory L Branigan, Kathleen Rodgers & Roberta Diaz Brinton. (2021) Association between menopausal hormone therapy and risk of neurodegenerative diseases: Implications for precision hormone therapy. Alzheimer's & Dementia: Translational Research & Clinical Interventions 7:1.
Crossref
Paulius Jonaitis, Laimas Jonaitis & Juozas Kupcinskas. (2020) Role of Genetic Polymorphisms of Cytochrome P450 2C19 in Pantoprazole Metabolism and Pantoprazole-based Helicobacter pylori Eradication Regimens. Current Drug Metabolism 21:11, pages 830-837.
Crossref
Beatriz Carvalho Henriques, Esther H. Yang, Diego Lapetina, Michael S. Carr, Vasyl Yavorskyy, Joshua Hague & Katherine J. Aitchison. (2020) How Can Drug Metabolism and Transporter Genetics Inform Psychotropic Prescribing?. Frontiers in Genetics 11.
Crossref
Jai N Patel & Issam S Hamadeh. (2020) Pharmacogenomics-guided opioid management. BMJ Supportive & Palliative Care 10:4, pages 374-378.
Crossref
Sisi Feng, Jiaying Wu, Wei-Lin Qiu, Li Yang, Xiaogang Deng, Ying Zhou, Yabin Chen, Xiao Li, Lei Yu, Hongsheng Li, Zi-Ran Xu, Yini Xiao, Xiongzhao Ren, Ludi Zhang, Chenhua Wang, Zhen Sun, Jinglin Wang, Xiaoyan Ding, Yuelei Chen, Paul Gadue, Guoyu Pan, Mina Ogawa, Shinichiro Ogawa, Jie Na, Peilin Zhang, Lijian Hui, Hao Yin, Luonan Chen, Cheng-Ran Xu & Xin Cheng. (2020) Large-scale Generation of Functional and Transplantable Hepatocytes and Cholangiocytes from Human Endoderm Stem Cells. Cell Reports 33:10, pages 108455.
Crossref
Rohit Sharma & Pradeep Kumar Prajapati. (2020) Predictive, Preventive and Personalized Medicine: Leads From Ayurvedic Concept of Prakriti (Human Constitution). Current Pharmacology Reports 6:6, pages 441-450.
Crossref
Sarika Daripally & Kiranmayi Peddi. (2020) Polymorphic variants of drug-metabolizing enzymes alter the risk and survival of oral cancer patients. 3 Biotech 10:12.
Crossref
Sri Krishna Jayadev Magani, Sri Durgambica Mupparthi, Bhanu Prakash Gollapalli, Dhananjay Shukla, AK Tiwari, Jyotsna Gorantala, Nagendra Sastry Yarla & Srinivasan Tantravahi. (2020) Salidroside - Can it be a Multifunctional Drug?. Current Drug Metabolism 21:7, pages 512-524.
Crossref
Zhao-Bo Luo, Saeed Ur. Rahman, Mei-Fu Xuan, Sheng-Zhong Han, Zhou-Yan Li, Xi-Jun Yin & Jin-Dan Kang. (2020) The protective role of ginsenoside compound K in porcine oocyte meiotic maturation failed caused by benzo(a)pyrene during in vitro maturation. Theriogenology 157, pages 96-109.
Crossref
Qiang Li, Wenbin Zhou, Yuyan Wang, Fang Kou, Chunming Lyu & Hai Wei. (2020) Metabolic mechanism and anti-inflammation effects of sinomenine and its major metabolites N-demethylsinomenine and sinomenine-N-oxide. Life Sciences 261, pages 118433.
Crossref
Christian Lohasz, Flavio Bonanini, Lisa Hoelting, Kasper Renggli, Olivier Frey & Andreas Hierlemann. (2020) Predicting Metabolism‐Related Drug–Drug Interactions Using a Microphysiological Multitissue System. Advanced Biosystems 4:11.
Crossref
Himanshu Verma & Om Silakari. (2020) Investigating the Role of Missense SNPs on ALDH 1A1 mediated pharmacokinetic resistance to cyclophosphamide. Computers in Biology and Medicine 125, pages 103979.
Crossref
Xiao-dan Zhang, Ying-hui Li, Dao-xing Chen, Wei-wei You, Xiao-xia Hu, Bing-bing Chen, Guo-xin Hu & Jian-chang Qian. (2020) The effect of apatinib on pharmacokinetic profile of buspirone both in vivo and in vitro . Journal of Pharmacy and Pharmacology 72:10, pages 1405-1411.
Crossref

Displaying 200 of 580 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.