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Research Article

Hyperthermic radiosensitization: mode of action and clinical relevance

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Pages 399-408 | Published online: 03 Jul 2009

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H. P. Kok, G. C. van Rhoon, T. D. Herrera, J. Overgaard & J. Crezee. (2022) Biological modeling in thermoradiotherapy: present status and ongoing developments toward routine clinical use. International Journal of Hyperthermia 39:1, pages 1126-1140.
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Prerna Singh, John Eley, Ali Saeed, Binny Bhandary, Nayab Mahmood, Minjie Chen, Tijana Dukic, Sina Mossahebi, Dario B. Rodrigues, Javed Mahmood, Zeljko Vujaskovic & Hem D. Shukla. (2021) Effect of hyperthermia and proton beam radiation as a novel approach in chordoma cells death and its clinical implication to treat chordoma. International Journal of Radiation Biology 97:12, pages 1675-1686.
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Pernille B. Elming, Brita S. Sørensen, Harald Spejlborg, Jens Overgaard & Michael R. Horsman. (2021) Does the combination of hyperthermia with low LET (linear energy transfer) radiation induce anti-tumor effects equivalent to those seen with high LET radiation alone?. International Journal of Hyperthermia 38:1, pages 105-110.
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H. Petra Kok, Erik N. K. Cressman, Wim Ceelen, Christopher L. Brace, Robert Ivkov, Holger Grüll, Gail ter Haar, Peter Wust & Johannes Crezee. (2020) Heating technology for malignant tumors: a review. International Journal of Hyperthermia 37:1, pages 711-741.
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Nouraddin Abdi Goushbolagh, Marzieh Keshavarz, Mohammad Hosein Zare, Mohammad Hossein Bahreyni-Toosi, Masoud Kargar & Bagher Farhood. (2019) Photosensitizer effects of MWCNTs-COOH particles on CT26 fibroblastic cells exposed to laser irradiation. Artificial Cells, Nanomedicine, and Biotechnology 47:1, pages 1326-1334.
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Beomseok Son, Jaewan Jeon, Sungmin Lee, Hyunwoo Kim, Hyunkoo Kang, HyeSook Youn, Sunmi Jo & BuHyun Youn. (2019) Radiotherapy in combination with hyperthermia suppresses lung cancer progression via increased NR4A3 and KLF11 expression. International Journal of Radiation Biology 95:12, pages 1696-1707.
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Keon Mahmoudi, Alexandros Bouras, Dominique Bozec, Robert Ivkov & Constantinos Hadjipanayis. (2018) Magnetic hyperthermia therapy for the treatment of glioblastoma: a review of the therapy’s history, efficacy and application in humans. International Journal of Hyperthermia 34:8, pages 1316-1328.
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C. M. van Leeuwen, J. Crezee, A. L. Oei, N. A. P. Franken, L. J. A. Stalpers, A. Bel & H. P. Kok. (2018) The effect of time interval between radiotherapy and hyperthermia on planned equivalent radiation dose. International Journal of Hyperthermia 34:7, pages 901-909.
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Pei-Shin Jiang, Hsin-Yu Tsai, Philip Drake, Fu-Nien Wang & Chi-Shiun Chiang. (2017) Gadolinium-doped iron oxide nanoparticles induced magnetic field hyperthermia combined with radiotherapy increases tumour response by vascular disruption and improved oxygenation. International Journal of Hyperthermia 33:7, pages 770-778.
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A. L. Oei, L. E. M. Vriend, P. M. Krawczyk, M. R. Horsman, N. A. P. Franken & J. Crezee. (2017) Targeting therapy-resistant cancer stem cells by hyperthermia. International Journal of Hyperthermia 33:4, pages 419-427.
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Akihisa Takahashi, Eiichiro Mori, Yosuke Nakagawa, Atsuhisa Kajihara, Tadaaki Kirita, Douglas L. Pittman, Masatoshi Hasegawa & Takeo Ohnishi. (2017) Homologous recombination preferentially repairs heat-induced DNA double-strand breaks in mammalian cells. International Journal of Hyperthermia 33:3, pages 336-342.
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Robert V. Stigliano, Fridon Shubitidze, James D. Petryk, Levan Shoshiashvili, Alicia A. Petryk & P. Jack Hoopes. (2016) Mitigation of eddy current heating during magnetic nanoparticle hyperthermia therapy. International Journal of Hyperthermia 32:7, pages 735-748.
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Rolf Issels, Eric Kampmann, Roland Kanaar & Lars H. Lindner. (2016) Hallmarks of hyperthermia in driving the future of clinical hyperthermia as targeted therapy: translation into clinical application. International Journal of Hyperthermia 32:1, pages 89-95.
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Gerard C. van Rhoon. (2016) Is CEM43 still a relevant thermal dose parameter for hyperthermia treatment monitoring?. International Journal of Hyperthermia 32:1, pages 50-62.
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Michael R. Horsman. (2016) Realistic biological approaches for improving thermoradiotherapy. International Journal of Hyperthermia 32:1, pages 14-22.
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Michael R. Horsman. (2015) Therapeutic potential of using the vascular disrupting agent OXi4503 to enhance mild temperature thermoradiation. International Journal of Hyperthermia 31:5, pages 453-459.
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Wouter C.M. Numan, Lorne W. Hofstetter, Gyula Kotek, Jurriaan F. Bakker, Eric W. Fiveland, Gavin C. Houston, Guido Kudielka, Desmond T.B. Yeo & Margarethus M. Paulides. (2014) Exploration of MR-guided head and neck hyperthermia by phantom testing of a modified prototype applicator for use with proton resonance frequency shift thermometry. International Journal of Hyperthermia 30:3, pages 184-191.
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Bilyana M Dicheva & Gerben A Koning. (2014) Targeted thermosensitive liposomes: an attractive novel approach for increased drug delivery to solid tumors. Expert Opinion on Drug Delivery 11:1, pages 83-100.
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Sergio Maluta, Stefano Dall'oglio & Luisa Nadalini. (2010) Treatment for intermediate and high-risk prostate cancer: Controversial issues and the role of hyperthermia. International Journal of Hyperthermia 26:8, pages 765-774.
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Sunil Krishnan, Parmeswaran Diagaradjane & Sang Hyun Cho. (2010) Nanoparticle-mediated thermal therapy: Evolving strategies for prostate cancer therapy. International Journal of Hyperthermia 26:8, pages 775-789.
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Manfred Johannsen, Burghard Thiesen, Peter Wust & Andreas Jordan. (2010) Magnetic nanoparticle hyperthermia for prostate cancer. International Journal of Hyperthermia 26:8, pages 790-795.
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Timothy M. Zagar, James R. Oleson, Zeljko Vujaskovic, Mark W. Dewhirst, Oana I. Craciunescu, Kimberly L. Blackwell, Leonard R. Prosnitz & Ellen L. Jones. (2010) Hyperthermia for locally advanced breast cancer. International Journal of Hyperthermia 26:7, pages 618-624.
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Timothy M. Zagar, James R. Oleson, Zeljko Vujaskovic, Mark W. Dewhirst, Oana I. Craciunescu, Kimberly L. Blackwell, Leonard R. Prosnitz & Ellen L. Jones. (2010) Hyperthermia combined with radiation therapy for superficial breast cancer and chest wall recurrence: A review of the randomised data. International Journal of Hyperthermia 26:7, pages 612-617.
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Xin Chen, Chris J. Diederich, Jeffery H. Wootton, Jean Pouliot & I-Chow Hsu. (2010) Optimisation-based thermal treatment planning for catheter-based ultrasound hyperthermia. International Journal of Hyperthermia 26:1, pages 39-55.
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Elisabetta Pennacchioli, Marco Fiore & Alessandro Gronchi. (2009) Hyperthermia as an adjunctive treatment for soft-tissue sarcoma. Expert Review of Anticancer Therapy 9:2, pages 199-210.
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Andrei Laszlo & Ilona Fleischer. (2009) The heat-induced γ-H2AX response does not play a role in hyperthermic cell killing. International Journal of Hyperthermia 25:3, pages 199-209.
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Tsutomu Sugahara, J. Van Der Zee, Harm H. Kampinga, Zeliko Vujaskovic, Motoharu Kondo, Takeo Ohnishi, Gloria Li, Heon J. Park, Dennis B. Leeper, Valentina Ostapenko, Elizabeth A. Repasky, Masami Watanabe & Chang W. Song. (2008) Kadota Fund International Forum 2004. Application of thermal stress for the improvement of health, 15–18 June 2004, Awaji Yumebutai International Conference Center, Awaji Island, Hyogo, Japan. Final Report. International Journal of Hyperthermia 24:2, pages 123-140.
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George Iliakis, Wenqi Wu & Minli Wang. (2008) DNA double strand break repair inhibition as a cause of heat radiosensitization: Re-evaluation considering backup pathways of NHEJ. International Journal of Hyperthermia 24:1, pages 17-29.
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M. Xu, R. J. Myerson, Y. Xia, T. Whitehead, E. G. Moros, W. L. Straube & J. L. Roti Roti. (2007) The effects of 41°C hyperthermia on the DNA repair protein, MRE11, correlate with radiosensitization in four human tumor cell lines. International Journal of Hyperthermia 23:4, pages 343-351.
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J. W. J. Bergs, N. A. P. Franken, J. Haveman, E. D. Geijsen, J. Crezee & C. van Bree. (2007) Hyperthermia, cisplatin and radiation trimodality treatment: A promising cancer treatment? A review from preclinical studies to clinical application. International Journal of Hyperthermia 23:4, pages 329-341.
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Andrei Laszlo, Teri Davidson, Amanda Harvey, Julia E. Sim, Robert S. Malyapa, Douglas R. Spitz & Joseph L. Roti Roti. (2006) Alterations in heat-induced radiosensitization accompanied by nuclear structure alterations in Chinese hamster cells. International Journal of Hyperthermia 22:1, pages 43-60.
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Gerard C. van Rhoon & Peter Wust. (2005) Introduction: Non-invasive thermometry for thermotherapy. International Journal of Hyperthermia 21:6, pages 489-495.
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H. H. Kampinga, J. R. Dynlacht & E. Dikomey. (2004) Mechanism of radiosensitization by hyperthermia (43°C) as derived from studies with DNA repair defective mutant cell lines. International Journal of Hyperthermia 20:2, pages 131-139.
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R. P. Vanderwaal & J. L. Roti Roti. (2004) Heat induced ‘masking’ of redox sensitive component(s) of the DNA-nuclear matrix anchoring complex. International Journal of Hyperthermia 20:2, pages 234-239.
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M. Xu, R. J. Myerson, C. Hunt, S. Kumar, E. G. Moros, W. L. Straube & J. L. Roti Roti. (2004) Transfection of human tumour cells with Mre11 siRNA and the increase in radiation sensitivity and the reduction in heat-induced radiosensitization. International Journal of Hyperthermia 20:2, pages 157-162.
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R. J. Myerson, J. L. Roti Roti, E. G. Moros, W. L. Straube & M. Xu. (2004) Modelling heat-induced radiosensitization: clinical implications. International Journal of Hyperthermia 20:2, pages 201-212.
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M. Purschke, U. Kasten‐Pisula, I. Brammer & E. Dikomey. (2004) Human and rodent cell lines showing no differences in the induction but differing in the repair kinetics of radiation‐induced DNA base damage. International Journal of Radiation Biology 80:1, pages 29-38.
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N. Umeda, Y. Matsumoto, H.‐L. Yin, M. Tomita, A. Enomoto, A. Morita, T. Mizukoshi, K. Sakai, Y. Hosoi & N. Suzuki. (2003) Difference in the heat sensitivity of DNA‐dependent protein kinase activity among mouse, hamster and human cells. International Journal of Radiation Biology 79:8, pages 671-680.
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M. W. Dewhirst, M. Lora-Michiels, B. L. Viglianti, W. C. Dewey & M. Repacholi. (2003) Carcinogenic effects of hyperthermia. International Journal of Hyperthermia 19:3, pages 236-251.
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James R. Lepock. (2003) Cellular effects of hyperthermia: relevance to the minimum dose for thermal damage. International Journal of Hyperthermia 19:3, pages 252-266.
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