225
Views
789
CrossRef citations to date
0
Altmetric
Cell Growth and Development

ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1

&
Pages 4129-4139 | Received 07 Feb 2001, Accepted 23 Mar 2001, Published online: 28 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (44)

Sissel Hauge, Adrian Eek Mariampillai, Gro Elise Rødland, Lilli T. E. Bay, Helga B. Landsverk & Randi G. Syljuåsen. (2023) Expanding roles of cell cycle checkpoint inhibitors in radiation oncology. International Journal of Radiation Biology 99:6, pages 941-950.
Read now
Stephanie M. Ackerson, Caroline I. Gable & Jason A. Stewart. (2020) Human CTC1 promotes TopBP1 stability and CHK1 phosphorylation in response to telomere dysfunction and global replication stress. Cell Cycle 19:24, pages 3491-3507.
Read now
Diletta Ciardo, Olivier Haccard, Hemalatha Narassimprakash, Virginie Chiodelli, Arach Goldar & Kathrin Marheineke. (2020) Polo-like kinase 1 (Plk1) is a positive regulator of DNA replication in the Xenopus in vitro system. Cell Cycle 19:14, pages 1817-1832.
Read now
Pu Rum Kim, Yen Ling Koon, Raphael Tze Chuen Lee, Farouq Azizan, Dylan Hong Zheng Koh, Keng-Hwee Chiam & Cheng-Gee Koh. (2020) Phosphatase POPX2 interferes with cell cycle by interacting with Chk1. Cell Cycle 19:4, pages 405-418.
Read now
Shin-Young Kim, Sun-Yi Hyun & Young-Joo Jang. (2019) Dephosphorylation of Plk1 occurs through PP2A-B55/ENSA/Greatwall pathway during mitotic DNA damage recovery. Cell Cycle 18:10, pages 1154-1167.
Read now
Xiaomei Hu, Zhe Li, Yuehe Ding, Qizhi Geng, Zhikai Xiahou, Huanwei Ru, Meng-Qiu Dong, Xingzhi Xu & Jing Li. (2018) Chk1 modulates the interaction between myosin phosphatase targeting protein 1 (MYPT1) and protein phosphatase 1cβ (PP1cβ). Cell Cycle 17:4, pages 421-427.
Read now
Ruiling Mu, John Tat, Robert Zamudio, Yaoyang Zhang, John R. Yates$suffix/text()$suffix/text(), Akiko Kumagai, William G. Dunphy & Steven I. Reed. (2017) CKS Proteins Promote Checkpoint Recovery by Stimulating Phosphorylation of Treslin. Molecular and Cellular Biology 37:20.
Read now
Abby M. Green, Sébastien Landry, Konstantin Budagyan, Daphne C. Avgousti, Sophia Shalhout, Ashok S. Bhagwat & Matthew D. Weitzman. (2016) APOBEC3A damages the cellular genome during DNA replication. Cell Cycle 15:7, pages 998-1008.
Read now
Ann Christin Parplys, Jasna Irena Seelbach, Saskia Becker, Matthias Behr, Agnieszka Wrona, Camilla Jend, Wael Yassin Mansour, Simon Andreas Joosse, Horst-Werner Stuerzbecher, Helmut Pospiech, Cordula Petersen, Ekkehard Dikomey & Kerstin Borgmann. (2015) High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation. Cell Cycle 14:19, pages 3190-3202.
Read now
Léonard Jagot-Lacoussiere, Audrey Faye, Heriberto Bruzzoni-Giovanelli, Bruno O Villoutreix, Jean-Christophe Rain & Jean-Luc Poyet. (2015) DNA damage-induced nuclear translocation of Apaf-1 is mediated by nucleoporin Nup107. Cell Cycle 14:8, pages 1242-1251.
Read now
Maomao Zhang, Priyanka Kothari, Mary Mullins & Michael A. Lampson. (2014) Regulation of zygotic genome activation and DNA damage checkpoint acquisition at the mid-blastula transition. Cell Cycle 13:24, pages 3828-3838.
Read now
A. Balupuri, P.K. Balasubramanian, C.G. Gadhe & S.J. Cho. (2014) Docking-based 3D-QSAR study of pyridyl aminothiazole derivatives as checkpoint kinase 1 inhibitors. SAR and QSAR in Environmental Research 25:8, pages 651-671.
Read now
Neil Beeharry, Eugenia Banina, James Hittle, Natalia Skobeleva, Vladimir Khazak, Sean Deacon, Mark Andrake, Brian L Egleston, Jeffrey R Peterson, Igor Astsaturov & Timothy J Yen. (2014) Re-purposing clinical kinase inhibitors to enhance chemosensitivity by overriding checkpoints. Cell Cycle 13:14, pages 2172-2191.
Read now
María Llanos Valero, Francisco Jose Cimas, Laura Arias, Pedro Melgar-Rojas, Elena García, Juan Luis Callejas-Valera, Jesús García-Cano, Leticia Serrano-Oviedo, Miguel Ángel de la Cruz-Morcillo, Isabel Sánchez-Pérez & Ricardo Sánchez-Prieto. (2014) E1a promotes c-Myc-dependent replicative stress. Cell Cycle 13:1, pages 52-61.
Read now
Neil Beeharry, Jerome Rattner, Juliane Caviston & Tim Yen. (2013) Centromere fragmentation is a common mitotic defect of S and G2 checkpoint override. Cell Cycle 12:10, pages 1588-1597.
Read now
Michael Rainey, Brendan Harhen, Guan-Nan Wang, Paul Murphy & Corrado Santocanale. (2013) Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint. Cell Cycle 12:10, pages 1560-1568.
Read now
Jiwon Huh & Helen Piwnica-Worms. (2013) CRL4CDT2 Targets CHK1 for PCNA-Independent Destruction. Molecular and Cellular Biology 33:2, pages 213-226.
Read now
Min Hwa Shin, Ming Yuan, Hao Zhang, Joseph B. Margolick & Mihoko Kai. (2012) ATM-dependent phosphorylation of the checkpoint clamp regulates repair pathways and maintains genomic stability. Cell Cycle 11:9, pages 1796-1803.
Read now
Deborah Wilsker, Jon H. Chung & Fred Bunz. (2012) Chk1 suppresses bypass of mitosis and tetraploidization in p53-deficient cancer cells. Cell Cycle 11:8, pages 1564-1572.
Read now
Yumay Chen, Chi-Fen Chen, Daniel J. Riley & Phang-Lang Chen. (2011) Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR. Cell Cycle 10:4, pages 655-663.
Read now
Jingna Wang, Staci Engle & Youwei Zhang. (2011) A new in vitro system for activating the cell cycle checkpoint . Cell Cycle 10:3, pages 500-506.
Read now
Rainer Poltz, Raimo Franke, Katrin Schweitzer, Steffen Klamt, Ernst-Dieter Gilles & Michael Naumann. (2009) Logical network of genotoxic stress-induced NF-κB signal transduction predicts putative target structures for therapeutic intervention strategies. Advances and Applications in Bioinformatics and Chemistry 2, pages 125-138.
Read now
Andriy Marusyk, Linda J. Wheeler, Christopher K. Mathews & James DeGregori. (2007) p53 Mediates Senescence-Like Arrest Induced by Chronic Replicational Stress. Molecular and Cellular Biology 27:15, pages 5336-5351.
Read now
XiaoZhe Wang, Richard D. Kennedy, Kallol Ray, Patricia Stuckert, Tom Ellenberger & Alan D. D'Andrea. (2007) Chk1-Mediated Phosphorylation of FANCE Is Required for the Fanconi Anemia/BRCA Pathway. Molecular and Cellular Biology 27:8, pages 3098-3108.
Read now
Hiroyuki Niida, Yuko Katsuno, Birendranath Banerjee, M. Prakash Hande & Makoto Nakanishi. (2007) Specific Role of Chk1 Phosphorylations in Cell Survival and Checkpoint Activation. Molecular and Cellular Biology 27:7, pages 2572-2581.
Read now
Courtney A. Lovejoy, Kimberli Lock, Ashwini Yenamandra & David Cortez. (2006) DDB1 Maintains Genome Integrity through Regulation of Cdt1. Molecular and Cellular Biology 26:21, pages 7977-7990.
Read now
Van Leung-Pineda, Christine E. Ryan & Helen Piwnica-Worms. (2006) Phosphorylation of Chk1 by ATR Is Antagonized by a Chk1-Regulated Protein Phosphatase 2A Circuit. Molecular and Cellular Biology 26:20, pages 7529-7538.
Read now
Shizhou Liu, Simon Bekker-Jensen, Niels Mailand, Claudia Lukas, Jiri Bartek & Jiri Lukas. (2006) Claspin Operates Downstream of TopBP1 To Direct ATR Signaling towards Chk1 Activation. Molecular and Cellular Biology 26:16, pages 6056-6064.
Read now
Ja-Eun Kim, Sarah A. McAvoy, David I. Smith & Junjie Chen. (2005) Human TopBP1 Ensures Genome Integrity during Normal S Phase. Molecular and Cellular Biology 25:24, pages 10907-10915.
Read now
Ji Zhang, Shideng Bao, Ryohei Furumai, Katerina S. Kucera, Ambereen Ali, Nicolas M. Dean & Xiao-Fan Wang. (2005) Protein Phosphatase 5 Is Required for ATR-Mediated Checkpoint Activation. Molecular and Cellular Biology 25:22, pages 9910-9919.
Read now
Randi G. Syljuåsen, Claus Storgaard Sørensen, Lasse Tengbjerg Hansen, Kasper Fugger, Cecilia Lundin, Fredrik Johansson, Thomas Helleday, Maxwell Sehested, Jiri Lukas & Jiri Bartek. (2005) Inhibition of Human Chk1 Causes Increased Initiation of DNA Replication, Phosphorylation of ATR Targets, and DNA Breakage. Molecular and Cellular Biology 25:9, pages 3553-3562.
Read now
George Zachos, Michael D. Rainey & David A. F. Gillespie. (2005) Chk1-Dependent S-M Checkpoint Delay in Vertebrate Cells Is Linked to Maintenance of Viable Replication Structures. Molecular and Cellular Biology 25:2, pages 563-574.
Read now
Martin F. Arlt, Bo Xu, Sandra G. Durkin, Anne M. Casper, Michael B. Kastan & Thomas W. Glover. (2004) BRCA1 Is Required for Common-Fragile-Site Stability via Its G2/M Checkpoint Function. Molecular and Cellular Biology 24:15, pages 6701-6709.
Read now
Sally L. Davies, Phillip S. North, Alwyn Dart, Nicholas D. Lakin & Ian D. Hickson. (2004) Phosphorylation of the Bloom's Syndrome Helicase and Its Role in Recovery from S-Phase Arrest. Molecular and Cellular Biology 24:3, pages 1279-1291.
Read now
Susana Gonzalez, Carol Prives & Carlos Cordon-Cardo. (2003) p73α Regulation by Chk1 in Response to DNA Damage. Molecular and Cellular Biology 23:22, pages 8161-8171.
Read now
Robert S. Weiss, Philip Leder & Cyrus Vaziri. (2003) Critical Role for Mouse Hus1 in an S-Phase DNA Damage Cell Cycle Checkpoint. Molecular and Cellular Biology 23:3, pages 791-803.
Read now
Marikki Laiho & Leena Latonen. (2003) Cell cycle control, DNA damage checkpoints and cancer. Annals of Medicine 35:6, pages 391-397.
Read now
Timothy P. Heffernan, Dennis A. Simpson, Alexandra R. Frank, Alexandra N. Heinloth, Richard S. Paules, Marila Cordeiro-Stone & William K. Kaufmann. (2002) An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage. Molecular and Cellular Biology 22:24, pages 8552-8561.
Read now
Ester M. Hammond, Nicholas C. Denko, Mary Jo Dorie, Robert T. Abraham & Amato J. Giaccia. (2002) Hypoxia Links ATR and p53 through Replication Arrest. Molecular and Cellular Biology 22:6, pages 1834-1843.
Read now

Articles from other publishers (745)

Chiharu Uchida, Hiroyuki Niida, Satoshi Sakai, Kenta Iijima, Kyoko Kitagawa, Tatsuya Ohhata, Bunsyo Shiotani & Masatoshi Kitagawa. (2023) p130RB2 positively contributes to ATR activation in response to replication stress via the RPA32-ETAA1 axis. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1870:6, pages 119484.
Crossref
Minakshi Mann, Vikram Pratap Singh & Lalit Kumar. (2023) Cervical cancer: a tale from HPV infection to PARP inhibitors. Genes & Diseases 10:4, pages 1445-1456.
Crossref
Jayme P. Coyle, Caroline Johnson, Jake Jensen, Mariana Farcas, Raymond Derk, Todd A. Stueckle, Tiffany G. Kornberg, Yon Rojanasakul & Liying W. Rojanasakul. (2023) Variation in pentose phosphate pathway-associated metabolism dictates cytotoxicity outcomes determined by tetrazolium reduction assays. Scientific Reports 13:1.
Crossref
Tanner J. Bakhshi, Tanner Way, Bradley Muncy & Philippe T. Georgel. (2023) Effects of the omega-3 fatty acid DHA on histone and p53 acetylation in diffuse large B cell lymphoma. Biochemistry and Cell Biology 101:2, pages 172-191.
Crossref
Benson Chellakkan Selvanesan, Sheelu Varghese, Justyna Andrys-Olek, Ricardo Hernandez Arriaza, Rahul Prakash, Purushottam Babu Tiwari, Daniel Hupalo, Yuriy Gusev, Megha Nitin Patel, Sara Contente, Miloslav Sanda, Aykut Uren, Matthew D. Wilkerson, Clifton Lee Dalgard, Linda S. Shimizu, Maksymilian Chruszcz, Tomasz Borowski & Geeta Upadhyay. (2023) Lymphocyte antigen 6K signaling to aurora kinase promotes advancement of the cell cycle and the growth of cancer cells, which is inhibited by LY6K-NSC243928 interaction. Cancer Letters 558, pages 216094.
Crossref
Hyeoncheol Kim, Luke B Villareal, Zhaoli Liu, Mohammad Haneef, Daniel M Falcon, David R Martin, Ho‐Joon Lee, Michael K Dame, Durga Attili, Ying Chen, James Varani, Jason R. Spence, Olga Kovbasnjuk, Justin A Colacino, Costas A. Lyssiotis, Henry C Lin, Yatrik M Shah & Xiang Xue. (2023) Transferrin Receptor‐Mediated Iron Uptake Promotes Colon Tumorigenesis. Advanced Science 10:10.
Crossref
Aadil Javed, Mahdieh Yarmohammadi, Kemal Sami Korkmaz & Teresa Rubio-Tomás. (2023) The Regulation of Cyclins and Cyclin-Dependent Kinases in the Development of Gastric Cancer. International Journal of Molecular Sciences 24:3, pages 2848.
Crossref
Mathijs Willemsen, John S. Barber, Erika Van Nieuwenhove, Frederik Staels, Margaux Gerbaux, Julika Neumann, Teresa Prezzemolo, Emanuela Pasciuto, Vasiliki Lagou, Nancy Boeckx, Jessica Filtjens, Amber De Visscher, Patrick Matthys, Rik Schrijvers, Thomas Tousseyn, Mark O’Driscoll, Giorgia Bucciol, Susan Schlenner, Isabelle Meyts, Stephanie Humblet-Baron & Adrian Liston. (2023) Homozygous DBF4 mutation as a cause of severe congenital neutropenia. Journal of Allergy and Clinical Immunology.
Crossref
Sushmitha Sriramulu, Shivani Thoidingjam, Stephen L. Brown, Farzan Siddiqui, Benjamin Movsas & Shyam Nyati. (2023) Molecular targets that sensitize cancer to radiation killing: From the bench to the bedside. Biomedicine & Pharmacotherapy 158, pages 114126.
Crossref
Bouchra Kitab & Kyoko Tsukiyama-Kohara. (2023) Regulatory Role of Ribonucleotide Reductase Subunit M2 in Hepatocyte Growth and Pathogenesis of Hepatitis C Virus. International Journal of Molecular Sciences 24:3, pages 2619.
Crossref
Yuandi Gao, Laure Guitton-Sert, Julien Dessapt, Yan Coulombe, Amélie Rodrigue, Larissa Milano, Andréanne Blondeau, Nicolai Balle Larsen, Julien P. Duxin, Samer Hussein, Amélie Fradet-Turcotte & Jean-Yves Masson. (2023) A CRISPR-Cas9 screen identifies EXO1 as a formaldehyde resistance gene. Nature Communications 14:1.
Crossref
Grigory V. Mechetin & Dmitry O. Zharkov. (2023) DNA Damage Response and Repair in Boron Neutron Capture Therapy. Genes 14:1, pages 127.
Crossref
Lena‐Christin Gruber, Barbara Schneider, Christin Nothnagel & Sandra Beer‐Hammer. (2022) Knockout of SLy1 decreases double‐negative thymocyte proliferation and protects mice from p53‐induced tumor formation. European Journal of Immunology 53:1.
Crossref
Sol Lee, Ha-Yeon Jee, Yoon-Gyeong Lee, Jong-Il Shin, Yong-Joon Jeon, Ji-Beom Kim, Hye-eun Seo, Ji-Yeon Lee & Kyungho Lee. (2022) PKR-Mediated Phosphorylation of eIF2a and CHK1 Is Associated with Doxorubicin-Mediated Apoptosis in HCC1143 Triple-Negative Breast Cancer Cells. International Journal of Molecular Sciences 23:24, pages 15872.
Crossref
Chao Dong, Yong Wang, Zhenlin Tu, Jingxue Yan, Yiqing Jiang, Tao Lu, Yadong Chen & Haichun Liu. (2022) Recent advances in ATM inhibitors as potential therapeutic agents. Future Medicinal Chemistry 14:23, pages 1811-1830.
Crossref
Ahmed Mobeen, Bhanwar Lal Puniya & Srinivasan Ramachandran. (2022) A computational approach to investigate constitutive activation of NF‐κB . Proteins: Structure, Function, and Bioinformatics 90:11, pages 1944-1964.
Crossref
Tiantian Xu, Qisheng Ma, Yanan Li, Qing Yu, Peichen Pan, Yawen Zheng, Zhijian Li, Xiufang Xiong, Tingjun Hou, Bin Yu, Hongmin Liu & Yi Sun. (2022) A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer. Signal Transduction and Targeted Therapy 7:1.
Crossref
Yasser Abuetabh, H. Helena Wu, Chengsen Chai, Habib Al Yousef, Sujata Persad, Consolato M. Sergi & Roger Leng. (2022) DNA damage response revisited: the p53 family and its regulators provide endless cancer therapy opportunities. Experimental & Molecular Medicine 54:10, pages 1658-1669.
Crossref
Anya Golder, Louisa Nelson, Anthony Tighe, Bethany Barnes, Camilla Coulson-Gilmer, Robert D Morgan, Joanne C McGrail & Stephen S Taylor. (2022) Multiple-low-dose therapy: effective killing of high-grade serous ovarian cancer cells with ATR and CHK1 inhibitors. NAR Cancer 4:4.
Crossref
Semer Maksoud. (2022) The DNA Double-Strand Break Repair in Glioma: Molecular Players and Therapeutic Strategies. Molecular Neurobiology 59:9, pages 5326-5365.
Crossref
Moisés Ó. Fiesco-Roa, Benilde García-de Teresa, Paula Leal-Anaya, Renée van ‘t Hek, Talia Wegman-Ostrosky, Sara Frías & Alfredo Rodríguez. (2022) Fanconi anemia and dyskeratosis congenita/telomere biology disorders: Two inherited bone marrow failure syndromes with genomic instability. Frontiers in Oncology 12.
Crossref
Yuan Xiao, Jia-Wen Xiang, Qian Gao, Yue-Yue Bai, Zhao-Xia Huang, Xiao-Hui Hu, Ling Wang & David Wan-Cheng Li. (2022) MAB21L1 promotes survival of lens epithelial cells through control of αB-crystallin and ATR/CHK1/p53 pathway. Aging 14:15, pages 6128-6148.
Crossref
Qi Long, Lijie Feng, Yuan Li, Tao Zuo, Lei Chang, Zhenpeng Zhang & Ping Xu. (2022) Time-resolved quantitative phosphoproteomics reveals cellular responses induced by caffeine and coumarin. Toxicology and Applied Pharmacology 449, pages 116115.
Crossref
Mayuko Ide, Noriko Tabata, Yuko Yonemura, Takayoshi Shirasaki, Kazuhisa Murai, Ying Wang, Atsuya Ishida, Hikari Okada, Masao Honda, Shuichi Kaneko, Nobuhide Doi, Satoru Ito & Hiroshi Yanagawa. (2022) Guanine nucleotide exchange factor DOCK11-binding peptide fused with a single chain antibody inhibits hepatitis B virus infection and replication. Journal of Biological Chemistry 298:7, pages 102097.
Crossref
Patrycja Gralewska, Arkadiusz Gajek, Dorota Rybaczek, Agnieszka Marczak & Aneta Rogalska. (2022) The Influence of PARP, ATR, CHK1 Inhibitors on Premature Mitotic Entry and Genomic Instability in High-Grade Serous BRCAMUT and BRCAWT Ovarian Cancer Cells. Cells 11:12, pages 1889.
Crossref
Barbara Guerra, Thomas K. Doktor, Sabrina B. Frederiksen, Kumar Somyajit & Brage S. Andresen. (2022) Essential role of CK2α for the interaction and stability of replication fork factors during DNA synthesis and activation of the S-phase checkpoint. Cellular and Molecular Life Sciences 79:6.
Crossref
Mengyuan Li, Xingjiu Yang, Guoxin Zhang, Le Wang, Ziwei Zhu, Wenlong Zhang, Hao Huang & Ran Gao. (2022) Heterogeneous nuclear ribonucleoprotein K promotes the progression of lung cancer by inhibiting the p53‐dependent signaling pathway. Thoracic Cancer 13:9, pages 1311-1321.
Crossref
Nan Ding, Zhiang Shao, Fangyun Yuan, Pei Qu, Ping Li, Dong Lu, Jufang Wang & Qianzheng Zhu. (2022) Chk1 Inhibition Hinders the Restoration of H3.1K56 and H3.3K56 Acetylation and Reprograms Gene Transcription After DNA Damage Repair. Frontiers in Oncology 12.
Crossref
Sachita Ganesa, Amrita Sule, Ranjini K. Sundaram & Ranjit S. Bindra. (2022) Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma. Scientific Reports 12:1.
Crossref
Michiko Yamato, Jun Hasegawa, Takanori Maejima, Chiharu Hattori, Kazuyoshi Kumagai, Akiko Watanabe, Yumi Nishiya, Tomoko Shibutani, Tetsuo Aida, Ichiro Hayakawa, Takashi Nakada, Yuki Abe & Toshinori Agatsuma. (2022) DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-Based Antibody–Drug Conjugate Targeting B7-H3, Exerts Potent Antitumor Activities in Preclinical Models. Molecular Cancer Therapeutics 21:4, pages 635-646.
Crossref
Nizar Al-Shar’i & Sondos S. Musleh. (2021) CHK1 kinase inhibition: identification of allosteric hits using MD simulations, pharmacophore modeling, docking and MM-PBSA calculations. Molecular Diversity 26:2, pages 903-921.
Crossref
Seyed Isaac Hashemy & Seyed Mohammad Reza Seyedi. 2022. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects 1375 1393 .
Victor Lewitzki & Michael Flentje. 2022. Medikamentöse Tumortherapie von Kopf-Hals-Tumoren. Medikamentöse Tumortherapie von Kopf-Hals-Tumoren 263 295 .
Iraia García-Santisteban, Alba Llopis, Lenno Krenning, Jon Vallejo-Rodríguez, Bram van den Broek, Ana M. Zubiaga & René H. Medema. (2021) Sustained CHK2 activity, but not ATM activity, is critical to maintain a G1 arrest after DNA damage in untransformed cells. BMC Biology 19:1.
Crossref
Lionel Condé, Yulemi Gonzalez Quesada, Florence Bonnet-Magnaval, Rémy Beaujois & Luc DesGroseillers. (2021) STAU2 protein level is controlled by caspases and the CHK1 pathway and regulates cell cycle progression in the non-transformed hTERT-RPE1 cells. BMC Molecular and Cell Biology 22:1.
Crossref
Caglar Berkel & Ercan Cacan. (2021) Estrogen- and estrogen receptor (ER)-mediated cisplatin chemoresistance in cancer. Life Sciences 286, pages 120029.
Crossref
Haidée Aranda-Tavío, Carlota Recio, Pedro Martín-Acosta, Miguel Guerra-Rodríguez, Yeray Brito-Casillas, Rosa Blanco, Vanessa Junco, Javier León, Juan Carlos Montero, Lucía Gandullo-Sánchez, Grant McNaughton-Smith, Juan Manuel Zapata, Atanasio Pandiella, Angel Amesty, Ana Estévez-Braun, Leandro Fernández-Pérez & Borja Guerra. (2021) JKST6, a novel multikinase modulator of the BCR-ABL1/STAT5 signaling pathway that potentiates direct BCR-ABL1 inhibition and overcomes imatinib resistance in chronic myelogenous leukemia. Biomedicine & Pharmacotherapy 144, pages 112330.
Crossref
Manni Wang, Siyuan Chen & Danyi Ao. (2021) Targeting DNA repair pathway in cancer: Mechanisms and clinical application. MedComm 2:4, pages 654-691.
Crossref
Gabriel E. Matos-Rodrigues & Rodrigo A. P. Martins. (2021) An Eye in the Replication Stress Response: Lessons From Tissue-Specific Studies in vivo. Frontiers in Cell and Developmental Biology 9.
Crossref
Faliang Wang, Kiran Vij, Lin Li, Paarth Dodhiawala, Kian-Huat Lim & Jieya Shao. (2021) Phospho-Ser784-VCP Drives Resistance of Pancreatic Ductal Adenocarcinoma to Genotoxic Chemotherapies and Predicts the Chemo-Sensitizing Effect of VCP Inhibitor. Cancers 13:20, pages 5076.
Crossref
Haiying Zhu, Zijian Rao, Sichen Yuan, Jieqiong You, Chenggang Hong, Qiaojun He, Bo Yang, Chengyong Du & Ji Cao. (2021) One therapeutic approach for triple-negative breast cancer: Checkpoint kinase 1 inhibitor AZD7762 combination with neoadjuvant carboplatin. European Journal of Pharmacology 908, pages 174366.
Crossref
Sonja J. Gill, Paul W.G. Wijnhoven, Jacqueline H.L. Fok, Rebecca L. Lloyd, Jonathan Cairns, Joshua Armenia, Jenni Nikkilä, Alan Lau, Christopher J. Bakkenist, Susan M. Galbraith, Conchita Vens & Mark J. O'Connor. (2021) Radiopotentiation Profiling of Multiple Inhibitors of the DNA Damage Response for Early Clinical Development. Molecular Cancer Therapeutics 20:9, pages 1614-1626.
Crossref
Liz Hernandez Borrero, David T Dicker, John Santiago, Jennifer Sanders, Xiaobing Tian, Nagib Ahsan, Avital Lev, Lanlan Zhou & Wafik S El-Deiry. (2021) A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53. eLife 10.
Crossref
Lydia E. Hainley, Martina S. Hughson, Amithi Narendran, Ralph Smith, Justin Arthur, Alida Hayner-Buchan, David J. Conti, John M. Lehman & Thomas D. Friedrich. (2021) Chk1 and the Host Cell DNA Damage Response as a Potential Antiviral Target in BK Polyomavirus Infection. Viruses 13:7, pages 1353.
Crossref
Yo-Chuen Lin & Supriya G. Prasanth. (2021) Replication initiation: Implications in genome integrity. DNA Repair 103, pages 103131.
Crossref
Erfan Mohammadi, Fatemeh Sadoughi, Simin Younesi, Ansar Karimian, Zatollah Asemi, Nader Farsad-Akhtar, Fahime Jahanbakhshi, Hamidreza Jamilian & Bahman Yousefi. (2021) The molecular mechanism of nuclear signaling for degradation of cytoplasmic DNA: Importance in DNA damage response and cancer. DNA Repair 103, pages 103115.
Crossref
Jekaterina Vohhodina, Liana J. Goehring, Ben Liu, Qing Kong, Vladimir V. Botchkarev, Mai Huynh, Zhiqi Liu, Fieda O. Abderazzaq, Allison P. Clark, Scott B. Ficarro, Jarrod A. Marto, Elodie Hatchi & David M. Livingston. (2021) BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage. Nature Communications 12:1.
Crossref
Kenji Iida, Amr H. Abdelhamid Ahmed, Akiko Kawano Nagatsuma, Tomoko Shibutani, Satoru Yasuda, Michiko Kitamura, Chiharu Hattori, Manabu Abe, Jun Hasegawa, Takuma Iguchi, Tsuyoshi Karibe, Takashi Nakada, Koichiro Inaki, Reiko Kamei, Yuki Abe, Taisei Nomura, Jessica L. Andersen, Sandro Santagata, Matthew L. Hemming, Suzanne George, Toshihiko Doi, Atsushi Ochiai, George D. Demetri & Toshinori Agatsuma. (2021) Identification and Therapeutic Targeting of GPR20, Selectively Expressed in Gastrointestinal Stromal Tumors, with DS-6157a, a First-in-Class Antibody–Drug Conjugate. Cancer Discovery 11:6, pages 1508-1523.
Crossref
Shunsuke Hanaki, Makoto Habara & Midori Shimada. (2021) UV‐induced activation of ATR is mediated by UHRF2. Genes to Cells 26:6, pages 447-454.
Crossref
Myrto Moutafi, Panagiota Economopoulou, David Rimm & Amanda Psyrri. (2021) PARP inhibitors in head and neck cancer: Molecular mechanisms, preclinical and clinical data. Oral Oncology 117, pages 105292.
Crossref
Tingting Jin, Peipei Wang, Xiubing Long, Kailong Jiang, Pinrao Song, Wenbiao Wu, Gaoya Xu, Yubo Zhou, Jia Li & Tao Liu. (2021) Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia. ChemMedChem 16:9, pages 1477-1487.
Crossref
Kathleen Ho, Hongwei Luo, Wei Zhu & Yi Tang. (2021) Critical role of SMG7 in activation of the ATR-CHK1 axis in response to genotoxic stress. Scientific Reports 11:1.
Crossref
Thomas J. Weitering, Sanami Takada, Corry M.R. Weemaes, Pauline A. van Schouwenburg & Mirjam van der Burg. (2021) ATM: Translating the DNA Damage Response to Adaptive Immunity. Trends in Immunology 42:4, pages 350-365.
Crossref
Timothy B. Branigan, David Kozono, Amy E. Schade, Peter Deraska, Hembly G. Rivas, Larissa Sambel, Hunter D. Reavis, Geoffrey I. Shapiro, Alan D. D’Andrea & James A. DeCaprio. (2021) MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity. Cell Reports 34:9, pages 108808.
Crossref
Ritu Chaudhary, Robbert J. C. Slebos, Feifei Song, Keegan P. McCleary‐Sharpe, Jude Masannat, Aik Choon Tan, Xuefeng Wang, Nelusha Amaladas, Wenjuan Wu, Gerald E. Hall, Jose R. Conejo‐Garcia, Juan C. Hernandez‐Prera & Christine H. Chung. (2020) Effects of checkpoint kinase 1 inhibition by prexasertib on the tumor immune microenvironment of head and neck squamous cell carcinoma. Molecular Carcinogenesis 60:2, pages 138-150.
Crossref
Kelli L. Goss, Stacia L. Koppenhafer, Torin Waters, William W. Terry, Kuo-Kuang Wen, Meng Wu, Jason Ostergaard, Peter M. Gordon & David J. Gordon. (2020) The translational repressor 4E-BP1 regulates RRM2 levels and functions as a tumor suppressor in Ewing sarcoma tumors. Oncogene 40:3, pages 564-577.
Crossref
Sapir Schlam‐Babayov, Ariel Bensimon, Michal Harel, Tamar Geiger, Ruedi Aebersold, Yael Ziv & Yosef Shiloh. (2020) Phosphoproteomics reveals novel modes of function and inter‐relationships among PIKKs in response to genotoxic stress. The EMBO Journal 40:2.
Crossref
Megan L. Hutchcraft, Holly H. Gallion & Jill M. Kolesar. (2021) MUTYH as an Emerging Predictive Biomarker in Ovarian Cancer. Diagnostics 11:1, pages 84.
Crossref
Sanne Løkkegaard, Daniel Elias, Carla L. Alves, Martin V. Bennetzen, Anne-Vibeke Lænkholm, Martin Bak, Morten F. Gjerstorff, Lene E. Johansen, Henriette Vever, Christina Bjerre, Tove Kirkegaard, Bo Nordenskjöld, Tommy Fornander, Olle Stål, Linda S. Lindström, Laura J. Esserman, Anne E. Lykkesfeldt, Jens S. Andersen, Rikke Leth-Larsen & Henrik J. Ditzel. (2021) MCM3 upregulation confers endocrine resistance in breast cancer and is a predictive marker of diminished tamoxifen benefit. npj Breast Cancer 7:1.
Crossref
Hanyi Jia. (2021) What Lies in between Telomere and Organismal Ageing: Comparison between Replicative Senescence and Stress-Induced Premature Senescence. E3S Web of Conferences 245, pages 03051.
Crossref
Mohamed-Elamir F. Hegazy, Mona Dawood, Nuha Mahmoud, Mohamed Elbadawi, Yoshikazu Sugimoto, Sabine M. Klauck, Nagla Mohamed & Thomas Efferth. (2021) 2α-Hydroxyalantolactone from Pulicaria undulata: activity against multidrug-resistant tumor cells and modes of action. Phytomedicine 81, pages 153409.
Crossref
Seyed Isaac Hashemy & Seyed Mohammad Reza Seyedi. 2020. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects 1 19 .
Yu-Che Cheng & Sheau-Yann Shieh. 2021. Cell Cycle Checkpoints. Cell Cycle Checkpoints 1 6 .
Jenna L. Carter, Katie Hege, Jay Yang, Hasini A. Kalpage, Yongwei Su, Holly Edwards, Maik Hüttemann, Jeffrey W. Taub & Yubin Ge. (2020) Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy. Signal Transduction and Targeted Therapy 5:1.
Crossref
Faizan H. Khan, Eoin Dervan, Dibyangana D. Bhattacharyya, Jake D. McAuliffe, Katrina M. Miranda & Sharon A. Glynn. (2020) The Role of Nitric Oxide in Cancer: Master Regulator or NOt?. International Journal of Molecular Sciences 21:24, pages 9393.
Crossref
Demis Menolfi & Shan Zha. (2020) ATM, ATR and DNA-PKcs kinases—the lessons from the mouse models: inhibition ≠ deletion. Cell & Bioscience 10:1.
Crossref
Jayme P. Coyle, Raymond C. Derk, Tiffany G. Kornberg, Dilpreet Singh, Jake Jensen, Sherri Friend, Robert Mercer, Todd A. Stueckle, Philip Demokritou, Yon Rojanasakul & Liying W. Rojanasakul. (2020) Carbon nanotube filler enhances incinerated thermoplastics-induced cytotoxicity and metabolic disruption in vitro. Particle and Fibre Toxicology 17:1.
Crossref
Keke Li, Shuang Zhao, Jing Long, Juan Su, Lisha Wu, Juan Tao, Jianda Zhou, JiangLin Zhang, Xiang Chen & Cong Peng. (2020) A novel chalcone derivative has antitumor activity in melanoma by inducing DNA damage through the upregulation of ROS products. Cancer Cell International 20:1.
Crossref
Kai Liu, Minying Zheng, Rui Lu, Jiaxing Du, Qi Zhao, Zugui Li, Yuwei Li & Shiwu Zhang. (2020) The role of CDC25C in cell cycle regulation and clinical cancer therapy: a systematic review. Cancer Cell International 20:1.
Crossref
Matthew R. Dewhurst, Jin Rong Ow, Gözde Zafer, Noémi K. M. van Hul, Heike Wollmann, Xavier Bisteau, David Brough, Hyungwon Choi & Philipp Kaldis. (2020) Loss of hepatocyte cell division leads to liver inflammation and fibrosis. PLOS Genetics 16:11, pages e1009084.
Crossref
Sanjeev Pasadi & Kalappa Muniyappa. (2020) Evidence for functional and regulatory cross-talk between Wnt/β-catenin signalling and Mre11-Rad50–Nbs1 complex in the repair of cisplatin-induced DNA cross-links. Oncotarget 11:44, pages 4028-4044.
Crossref
Rebecca Caeser & Triparna Sen. (2020) Should WEE(1) CHK(1) in on the FAM(122A)ily?. Molecular Cell 80:3, pages 377-378.
Crossref
Feng Li, David Kozono, Peter Deraska, Timothy Branigan, Connor Dunn, Xiao-Feng Zheng, Kalindi Parmar, Huy Nguyen, James DeCaprio, Geoffrey I. Shapiro, Dipanjan Chowdhury & Alan D. D’Andrea. (2020) CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress. Molecular Cell 80:3, pages 410-422.e6.
Crossref
Brooke A. Conti & Agata Smogorzewska. (2020) Mechanisms of direct replication restart at stressed replisomes. DNA Repair 95, pages 102947.
Crossref
Chen Xin, Zhang Chao, Wang Xian, Wang Zhonggao & Luo Tao. (2020) The phosphorylation of CHK1 at Ser345 regulates the phenotypic switching of vascular smooth muscle cells both in vitro and in vivo. Atherosclerosis 313, pages 50-59.
Crossref
Samantha Sharma & Micheala A. Aldred. (2020) DNA Damage and Repair in Pulmonary Arterial Hypertension. Genes 11:10, pages 1224.
Crossref
Svenja Wiechmann, Elena Saupp, Daniela Schilling, Stephanie Heinzlmeir, Günter Schneider, Roland M. Schmid, Stephanie E. Combs, Bernhard Kuster & Sophie Dobiasch. (2020) Radiosensitization by Kinase Inhibition Revealed by Phosphoproteomic Analysis of Pancreatic Cancer Cells. Molecular & Cellular Proteomics 19:10, pages 1649-1663.
Crossref
Lisa Prendergast, Urszula L. McClurg, Rossitsa Hristova, Rolando Berlinguer-Palmini, Sarah Greener, Katie Veitch, Inmaculada Hernandez, Philippe Pasero, Daniel Rico, Jonathan M. G. Higgins, Anastas Gospodinov & Manolis Papamichos-Chronakis. (2020) Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability. Nature Communications 11:1.
Crossref
Yahya Benslimane, Thierry Bertomeu, Jasmin Coulombe-Huntington, Mary McQuaid, María Sánchez-Osuna, David Papadopoli, Daina Avizonis, Mariana De Sa Tavares Russo, Caroline Huard, Ivan Topisirovic, Hugo Wurtele, Mike Tyers & Lea Harrington. (2020) Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells. Molecular Cell 79:5, pages 846-856.e8.
Crossref
Naira Movsisyan & Luis A. Pardo. (2020) Kv10.1 Regulates Microtubule Dynamics during Mitosis. Cancers 12:9, pages 2409.
Crossref
Jayakumar Nair, Tzu-Ting Huang, Junko Murai, Brittany Haynes, Patricia S. Steeg, Yves Pommier & Jung-Min Lee. (2020) Resistance to the CHK1 inhibitor prexasertib involves functionally distinct CHK1 activities in BRCA wild-type ovarian cancer. Oncogene 39:33, pages 5520-5535.
Crossref
Young Hwa Soung, Heesung Chung, Cecilia Yan, Andrew Fesler, Hyungjin Kim, Eok-Soo Oh, Jingfang Ju & Jun Chung. (2020) Therapeutic Potential of Chemically Modified miR-489 in Triple-Negative Breast Cancers. Cancers 12:8, pages 2209.
Crossref
Somsundar V Muralidharan, Lisa M Nilsson, Mattias F Lindberg & Jonas A Nilsson. (2020) Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cells. Life Science Alliance 3:8, pages e202000671.
Crossref
Catalina Pereira, Marcus B. Smolka, Robert S. Weiss & Miguel A. Brieño‐Enríquez. (2020) ATR signaling in mammalian meiosis: From upstream scaffolds to downstream signaling. Environmental and Molecular Mutagenesis 61:7, pages 752-766.
Crossref
Yalun Li, Yiran Liang, Tingting Ma & Qifeng Yang. (2020) Identification of DGUOK-AS1 as a Prognostic Factor in Breast Cancer by Bioinformatics Analysis. Frontiers in Oncology 10.
Crossref
Xuehai Wang, Xin Zhang, Chen Qiu & Ning Yang. (2020) STAT3 Contributes to Radioresistance in Cancer. Frontiers in Oncology 10.
Crossref
Zhihao Li, Keisuke Tamari, Yuji Seo, Kazumasa Minami, Yutaka Takahashi, Shotaro Tatekawa, Keisuke Otani, Osamu Suzuki, Fumiaki Isohashi & Kazuhiko Ogawa. (2020) Dihydroouabain, a novel radiosensitizer for cervical cancer identified by automated high-throughput screening. Radiotherapy and Oncology 148, pages 21-29.
Crossref
Takumi Mikawa, Eri Shibata, Midori Shimada, Ken Ito, Tomiko Ito, Hiroaki Kanda, Keiyo Takubo, Matilde E. Lleonart, Nobuya Inagaki, Masayuki Yokode & Hiroshi Kondoh. (2020) Phosphoglycerate Mutase Cooperates with Chk1 Kinase to Regulate Glycolysis. iScience 23:7, pages 101306.
Crossref
Kai Miao, Josh Haipeng Lei, Monica Vishnu Valecha, Aiping Zhang, Jun Xu, Lijian Wang, Xueying Lyu, Si Chen, Zhengqiang Miao, Xin Zhang, Sek Man Su, Fangyuan Shao, Barani Kumar Rajendran, Jiaolin Bao, Jianming Zeng, Heng Sun, Ping Chen, Kaeling Tan, Qiang Chen, Koon Ho Wong, Xiaoling Xu & Chu-Xia Deng. (2020) NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation. Nature Communications 11:1.
Crossref
David P. WatermanJames E. HaberMarcus B. Smolka. (2020) Checkpoint Responses to DNA Double-Strand Breaks. Annual Review of Biochemistry 89:1, pages 103-133.
Crossref
Kai-Feng HungJulia M. SidorovaPaul Nghiem & Masaoki Kawasumi. (2020) The 6-4 photoproduct is the trigger of UV-induced replication blockage and ATR activation. Proceedings of the National Academy of Sciences 117:23, pages 12806-12816.
Crossref
Zhen Chen, Chao Wang, Caoqi Lei, Xu Feng, Chen Li, Sung Yun Jung, Jun Qin & Junjie Chen. (2020) Phosphoproteomics Analysis Reveals a Potential Role of CHK1 in Regulation of Innate Immunity through IRF3. Journal of Proteome Research 19:6, pages 2264-2277.
Crossref
Shinya Ohashi, Osamu Kikuchi, Yukie Nakai, Tomomi Ida, Tomoki Saito, Yuki Kondo, Yoshihiro Yamamoto, Yosuke Mitani, Trang H. Nguyen Vu, Keita Fukuyama, Hiroshi Tsukihara, Norihiko Suzuki & Manabu Muto. (2020) Synthetic Lethality with Trifluridine/Tipiracil and Checkpoint Kinase 1 Inhibitor for Esophageal Squamous Cell Carcinoma. Molecular Cancer Therapeutics 19:6, pages 1363-1372.
Crossref
Diego Dibitetto, Jennie R Sims, Carolline F R Ascenção, Kevin Feng, Dongsung Kim, Susannah Oberly, Raimundo Freire & Marcus B Smolka. (2020) Intrinsic ATR signaling shapes DNA end resection and suppresses toxic DNA-PKcs signaling. NAR Cancer 2:2.
Crossref
Hua Gan, Ming Qi, Chakpiu Chan, Pan Leung, Geni Ye, Yuhe Lei, Aiai Liu, Feifei Xue, Dongdong Liu, Wencai Ye, Dongmei Zhang, Lijuan Deng & Jiaxu Chen. (2020) Digitoxin inhibits HeLa cell growth through the induction of G2/M cell cycle arrest and apoptosis in vitro and in vivo. International Journal of Oncology 57:2, pages 562-573.
Crossref
Eleni Petsalaki & George Zachos. (2020) DNA damage response proteins regulating mitotic cell division: double agents preserving genome stability. The FEBS Journal 287:9, pages 1700-1721.
Crossref
Katelyn B. Cassidy, Scott Bang, Manabu Kurokawa & Scott A. Gerber. (2019) Direct regulation of Chk1 protein stability by E3 ubiquitin ligase HUWE1. The FEBS Journal 287:10, pages 1985-1999.
Crossref
Debjani Pal, Adrian E. Torres, Benjamin R. Stromberg, Abbey L. Messina, Andrew S. Dickson, Kuntal De, Belinda Willard, Monica Venere & Matthew K. Summers. (2020) Chk1-mediated phosphorylation of Cdh1 promotes the SCFβTRCP-dependent degradation of Cdh1 during S-phase and efficient cell-cycle progression. Cell Death & Disease 11:4.
Crossref
Lei Ding, Jiaqi Cao, Wen Lin, Hongjian Chen, Xianhui Xiong, Hongshun Ao, Min Yu, Jie Lin & Qinghua Cui. (2020) The Roles of Cyclin-Dependent Kinases in Cell-Cycle Progression and Therapeutic Strategies in Human Breast Cancer. International Journal of Molecular Sciences 21:6, pages 1960.
Crossref
Demis Menolfi & Shan Zha. (2019) ATM, DNA-PKcs and ATR: shaping development through the regulation of the DNA damage responses. Genome Instability & Disease 1:2, pages 47-68.
Crossref
Jihane Basbous, Antoine Aze, Laurent Chaloin, Rana Lebdy, Dana Hodroj, Cyril Ribeyre, Marion Larroque, Caitlin Shepard, Baek Kim, Alain Pruvost, Jérôme Moreaux, Domenico Maiorano, Marcel Mechali & Angelos Constantinou. (2020) Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites. Nucleic Acids Research 48:4, pages 1886-1904.
Crossref
Nicholas J. H. Warren & Alan Eastman. (2019) Comparison of the different mechanisms of cytotoxicity induced by checkpoint kinase I inhibitors when used as single agents or in combination with DNA damage. Oncogene 39:7, pages 1389-1401.
Crossref
Veronica Marabitti, Giorgia Lillo, Eva Malacaria, Valentina Palermo, Pietro Pichierri & Annapaola Franchitto. (2020) Checkpoint Defects Elicit a WRNIP1-Mediated Response to Counteract R-Loop-Associated Genomic Instability. Cancers 12:2, pages 389.
Crossref
Varsha Wagh, Pranav Joshi, Heena Jariyal & Neelam Chauhan. (2020) ATM and ATR checkpoint kinase pathways: A concise review. Advances in Human Biology 10:2, pages 51.
Crossref
Mathilde R. W. de Jong, Myra Langendonk, Bart Reitsma, Pien Herbers, Monique Lodewijk, Marcel Nijland, Anke van den Berg, Emanuele Ammatuna, Lydia Visser & Tom van Meerten. (2020) WEE1 inhibition synergizes with CHOP chemotherapy and radiation therapy through induction of premature mitotic entry and DNA damage in diffuse large B-cell lymphoma. Therapeutic Advances in Hematology 11, pages 204062071989837.
Crossref
Agnieszka Smolinska, Julia Swoboda, Wojciech Fendler, Markus M. Lerch, Matthias Sendler & Patryk Moskwa. (2020) MiR-502 is the first reported miRNA simultaneously targeting two components of the classical non-homologous end joining (C-NHEJ) in pancreatic cell lines. Heliyon 6:1, pages e03187.
Crossref
Makoto Takeuchi, Michihiro Tanikawa, Kazunori Nagasaka, Katsutoshi Oda, Yoshiko Kawata, Shinya Oki, Chuwa Agapiti, Kenbun Sone, Yuko Miyagawa, Haruko Hiraike, Osamu Wada-Hiraike, Hiroyuki Kuramoto, Takuya Ayabe, Yutaka Osuga & Tomoyuki Fujii. (2019) Anti-Tumor Effect of Inhibition of DNA Damage Response Proteins, ATM and ATR, in Endometrial Cancer Cells. Cancers 11:12, pages 1913.
Crossref
Jazmine A. Snow, Vaibhav Murthy, Dalton Dacus, Changkun Hu & Nicholas A. Wallace. (2019) β-HPV 8E6 Attenuates ATM and ATR Signaling in Response to UV Damage. Pathogens 8:4, pages 267.
Crossref
Emil Mladenov, Xiaoxiang Fan, Katja Paul-Konietzko, Aashish Soni & George Iliakis. (2019) DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G2-checkpoint in S-phase irradiated cells. Scientific Reports 9:1.
Crossref
Swetha Parvathaneni & Sudha Sharma. (2019) The DNA repair helicase RECQ1 has a checkpoint-dependent role in mediating DNA damage responses induced by gemcitabine. Journal of Biological Chemistry 294:42, pages 15330-15345.
Crossref
Michael Charles Lanz, Diego Dibitetto & Marcus Bustamante Smolka. (2019) DNA damage kinase signaling: checkpoint and repair at 30 years . The EMBO Journal 38:18.
Crossref
Alice BourgeoisSébastien BonnetSandra Breuils-BonnetKarima HabboutRenée ParadisEve TremblayMarie-Claude LampronMark E. OrcholskiFrancois PotusThomas BerteroThibaut PeterliniStephen Y. ChanKaren A NorrisRoxane PaulinSteeve ProvencherOlivier Boucherat. (2019) Inhibition of CHK 1 (Checkpoint Kinase 1) Elicits Therapeutic Effects in Pulmonary Arterial Hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology 39:8, pages 1667-1681.
Crossref
Tatiana N. Moiseeva, Yandong YinMichael J. CalderonChenao QianSandra Schamus-HaynesNorie SugitaniHatice U. OsmanbeyogluEli RothenbergSimon C. WatkinsChristopher J. Bakkenist. (2019) An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication. Proceedings of the National Academy of Sciences 116:27, pages 13374-13383.
Crossref
Lexian Tong, Pinrao Song, Kailong Jiang, Lei Xu, Tingting Jin, Peipei Wang, Xiaobei Hu, Sui Fang, Anhui Gao, Yubo Zhou, Tao Liu, Jia Li & Yongzhou Hu. (2019) Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies. European Journal of Medicinal Chemistry 173, pages 44-62.
Crossref
Emil Mladenov, Xiaoxiang Fan, Rositsa Dueva, Aashish Soni & George Iliakis. (2019) Radiation-dose-dependent functional synergisms between ATM, ATR and DNA-PKcs in checkpoint control and resection in G2-phase. Scientific Reports 9:1.
Crossref
Xuyang Yao, Mengying Zhai, Lingyi Zhou & Liu Yang. (2019) Protective effects of SND1 in retinal photoreceptor cell damage induced by ionizing radiation. Biochemical and Biophysical Research Communications 514:3, pages 919-925.
Crossref
Hao Zhang, Fei Shao, Wei Guo, Yibo Gao & Jie He. (2019) Knockdown of KLF5 promotes cisplatin‐induced cell apoptosis via regulating DNA damage checkpoint proteins in non‐small cell lung cancer . Thoracic Cancer 10:5, pages 1069-1077.
Crossref
Nicole D. Vincelette, Husheng Ding, Amelia M. Huehls, Karen S. Flatten, Rebecca L. Kelly, Mira A. Kohorst, Jonathan Webster, Allan D. Hess, Keith W. Pratz, Larry M. Karnitz & Scott H. Kaufmann. (2019) Effect of CHK1 Inhibition on CPX-351 Cytotoxicity in vitro and ex vivo. Scientific Reports 9:1.
Crossref
Guoli Shao, Mengchuan Wang, Xulong Fan, Lin Zhong, Zixiang Wang, Pusheng Zhang & Shufeng Ji. (2019) lncRNA CASC9 positively regulates CHK1 to promote breast cancer cell proliferation and survival through sponging the miR‑195/497 cluster. International Journal of Oncology.
Crossref
Hidemasa Goto, Toyoaki Natsume, Masato T. Kanemaki, Aika Kaito, Shujie Wang, Esteban C. Gabazza, Masaki Inagaki & Akira Mizoguchi. (2019) Chk1-mediated Cdc25A degradation as a critical mechanism for normal cell-cycle progression. Journal of Cell Science.
Crossref
Diana Azenha, Maria Celeste Lopes & Teresa C. Martins. 2019. DNA Repair. DNA Repair 203 246 .
Randi G. Syljuåsen. 2019. Radiation Oncology. Radiation Oncology 1 8 .
Greg Ngo, Sam Hyatt, Julia Grimstead, Rhiannon Jones, Eric Hendrickson, Chris Pepper & Duncan Baird. (2018) PARP inhibition prevents escape from a telomere-driven crisis and inhibits cell immortalisation. Oncotarget 9:101, pages 37549-37563.
Crossref
Darshil R. PatelRobert S. Weiss. (2018) A tough row to hoe: when replication forks encounter DNA damage. Biochemical Society Transactions 46:6, pages 1643-1651.
Crossref
Linlin Song, Ximeng Han, Cunyu Jia, Xin Zhang, Yunjie Jiao, Taofeng Du, Shuqi Xiao, Julian A. Hiscox, En-Min Zhou & Yang Mu. (2018) Porcine reproductive and respiratory syndrome virus inhibits MARC-145 proliferation via inducing apoptosis and G2/M arrest by activation of Chk/Cdc25C and p53/p21 pathway. Virology Journal 15:1.
Crossref
Stacia L. Koppenhafer, Kelli L. Goss, William W. Terry & David J. Gordon. (2018) mTORC1/2 and Protein Translation Regulate Levels of CHK1 and the Sensitivity to CHK1 Inhibitors in Ewing Sarcoma Cells. Molecular Cancer Therapeutics 17:12, pages 2676-2688.
Crossref
Jinfang Zhang, Fabin Dang, Junming Ren & Wenyi Wei. (2018) Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy. Trends in Biochemical Sciences 43:12, pages 1014-1032.
Crossref
Ying Fan, Sumana Sanyal & Roberto Bruzzone. (2018) Breaking Bad: How Viruses Subvert the Cell Cycle. Frontiers in Cellular and Infection Microbiology 8.
Crossref
Junpeng Yan, Ming-Chieh Shun, Caili Hao, Yi Zhang, Juan Qian, Kasia Hrecka, Maria DeLucia, Christina Monnie, Jinwoo Ahn & Jacek Skowronski. (2018) HIV-1 Vpr Reprograms CLR4 DCAF1 E3 Ubiquitin Ligase to Antagonize Exonuclease 1-Mediated Restriction of HIV-1 Infection . mBio 9:5.
Crossref
Mingdong Liu, Taoling Zeng, Xin Zhang, Chunyan Liu, Zhihui Wu, Luming Yao, Changchuan Xie, Hui Xia, Qi Lin, Liping Xie, Dawang Zhou, Xianming Deng, Hong-Lin Chan, Tong-Jin Zhao & Hong-Rui Wang. (2018) ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage. Nature Communications 9:1.
Crossref
Wangdong Jin, Li Zhou, Bo Yan, Li Yan, Fucun Liu, Peijian Tong, Wenhua Yu, Xiaoqiao Dong, Li Xie, Jin Zhang, Yiqiao Xu, Chunqi Li, Qiang Yuan, Letian Shan & Thomas Efferth. (2018) Theabrownin triggers DNA damage to suppress human osteosarcoma U2 OS cells by activating p53 signalling pathway . Journal of Cellular and Molecular Medicine 22:9, pages 4423-4436.
Crossref
Stephanie Dynczuki Navarro, Lucas Roberto Pessatto, Alisson Meza, Edwin José Torres de Oliveira, Sarah Alves Auharek, Lizia Colares Vilela, Dênis Pires de Lima, Ricardo Bentes de Azevedo, Candida Aparecida Leite Kassuya, Osmar Ignacio Ayala Cáceres, Roberto da Silva Gomes, Adilson Beatriz, Rodrigo Juliano Oliveira & Marco Antonio Utrera Martines. (2018) Resorcinolic lipid 3-heptyl-3,4,6-trimethoxy-3H-isobenzofuran-1-one is a strategy for melanoma treatment. Life Sciences 209, pages 300-312.
Crossref
Trinayan Kashyap, Christian Argueta, Thaddeus Unger, Boris Klebanov, Sophia Debler, William Senapedis, Marsha L. Crochiere, Margaret S. Lee, Michael Kauffman, Sharon Shacham & Yosef Landesman. (2018) Selinexor reduces the expression of DNA damage repair proteins and sensitizes cancer cells to DNA damaging agents. Oncotarget 9:56, pages 30773-30786.
Crossref
Bor-Jang Hwang, Gautam Adhikary, Richard L. Eckert & A-Lien Lu. (2018) Chk1 inhibition as a novel therapeutic strategy in melanoma. Oncotarget 9:54, pages 30450-30464.
Crossref
Jingwen Zhang, Austin M. Dulak, Maureen M. Hattersley, Brandon S. Willis, Jenni Nikkilä, Anderson Wang, Alan Lau, Corinne Reimer, Michael Zinda, Stephen E. Fawell, Gordon B. Mills & Huawei Chen. (2018) BRD4 facilitates replication stress-induced DNA damage response. Oncogene 37:28, pages 3763-3777.
Crossref
Charlotte Trussart, Céline Pirlot, Emmanuel Di Valentin, Jacques Piette & Yvette Habraken. (2018) Melanoma antigen-D2 controls cell cycle progression and modulates the DNA damage response. Biochemical Pharmacology 153, pages 217-229.
Crossref
Dauren Alimbetov, Sholpan Askarova, Bauyrzhan Umbayev, Terence Davis & David Kipling. (2018) Pharmacological Targeting of Cell Cycle, Apoptotic and Cell Adhesion Signaling Pathways Implicated in Chemoresistance of Cancer Cells. International Journal of Molecular Sciences 19:6, pages 1690.
Crossref
Ramhari Kumbhar, Sophie Vidal-Eychenié, Dimitrios-Georgios Kontopoulos, Marion Larroque, Christian Larroque, Jihane Basbous, Sofia Kossida, Cyril Ribeyre & Angelos Constantinou. (2018) Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signalling. Life Science Alliance 1:3, pages e201800096.
Crossref
Yu-Che Cheng & Sheau-Yann Shieh. (2018) Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation. Proceedings of the National Academy of Sciences 115:21, pages 5546-5551.
Crossref
Kristin L Limpose, Kelly S Trego, Zhentian Li, Sara W Leung, Altaf H Sarker, Jason A Shah, Suresh S Ramalingam, Erica M Werner, William S Dynan, Priscilla K Cooper, Anita H Corbett & Paul W Doetsch. (2018) Overexpression of the base excision repair NTHL1 glycosylase causes genomic instability and early cellular hallmarks of cancer. Nucleic Acids Research 46:9, pages 4515-4532.
Crossref
Tyler J. Lahusen, Seung-Jin Kim, Kai Miao, Zebin Huang, Xiaoling Xu & Chu-Xia Deng. (2018) BRCA1 function in the intra-S checkpoint is activated by acetylation via a pCAF/SIRT1 axis. Oncogene 37:17, pages 2343-2350.
Crossref
Terri G. Edwards, David C. Bloom & Chris Fisher. (2018) The ATM and Rad3-Related (ATR) Protein Kinase Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication. Journal of Virology 92:6.
Crossref
Debadrita Bhattacharya, Disha Hiregange & Basuthkar J Rao. (2018) ATR kinase regulates its attenuation via PPM1D phosphatase recruitment to chromatin during recovery from DNA replication stress signalling. Journal of Biosciences 43:1, pages 25-47.
Crossref
Basem M. Jaber, Georg A. Petroianu, Syed A. Rizvi, Anwar Borai, Nada A. Saleh, Sharif M. Hala & Ayman M. Saleh. (2018) Protective effect of metoclopramide against organophosphate-induced apoptosis in the murine skin fibroblast L929. Journal of Applied Toxicology 38:3, pages 329-340.
Crossref
Yu-Fen Lin, Hung-Ying Shih, Zeng-Fu Shang, Ching-Te Kuo, Jiaming Guo, Chunying Du, Hsinyu Lee & Benjamin P C Chen. (2018) PIDD mediates the association of DNA-PKcs and ATR at stalled replication forks to facilitate the ATR signaling pathway. Nucleic Acids Research 46:4, pages 1847-1859.
Crossref
Juan Wei, Hailan Su, Yang Bi, Jixin Li, Lidan Feng & Wenjun Sheng. (2018) Anti-proliferative effect of isorhamnetin on HeLa cells through inducing G2/M cell cycle arrest. Experimental and Therapeutic Medicine.
Crossref
Hui Chen, Hudan Liu & Guoliang Qing. (2018) Targeting oncogenic Myc as a strategy for cancer treatment. Signal Transduction and Targeted Therapy 3:1.
Crossref
Tao Shen, Hongyu Zhou, Chaowei Shang, Yan Luo, Yang Wu & Shile Huang. (2018) Ciclopirox activates ATR-Chk1 signaling pathway leading to Cdc25A protein degradation. Genes & Cancer 9:1-2, pages 39-52.
Crossref
Martyna Wojtala, Ewa Macierzyńska-Piotrowska, Dorota Rybaczek, Luciano Pirola & Aneta Balcerczyk. (2018) Pharmacological and transcriptional inhibition of the G9a histone methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cells. Pharmacological Research 128, pages 252-263.
Crossref
Shadia A. Galal, Muhammad Khattab, Samia A. Shouman, Raghda Ramadan, Omaima M. Kandil, Omnia M. Kandil, Ashraf Tabll, Yasmine S. El Abd, Reem El-Shenawy, Yasmin M. Attia, Ahmed A. El-Rashedy & Hoda I. El Diwani. (2018) Part III: Novel checkpoint kinase 2 (Chk2) inhibitors; design, synthesis and biological evaluation of pyrimidine-benzimidazole conjugates. European Journal of Medicinal Chemistry 146, pages 687-708.
Crossref
Tianqi Yu, Suthakar Ganapathy, Ling Shen, Bo Peng, Sung-Hoon Kim, Alexandros Makriyannis & Changyan Chen. (2018) A lethal synergy induced by phellinus linteus and camptothecin11 in colon cancer cells. Oncotarget 9:5, pages 6308-6319.
Crossref
Toshiyuki Matsunaga, Kyoko Kamase, Hiroaki Takasawa, Yukiko Yamaji, Satoshi Endo, Ossama El-Kabbani & Akira Ikari. (2018) Facilitation of 9,10-phenanthrenequinone-elicited neuroblastoma cell apoptosis by NAD(P)H:quinone oxidoreductase 1. Chemico-Biological Interactions 279, pages 10-20.
Crossref
J. Klapacz & B.B. Gollapudi. 2018. Comprehensive Toxicology. Comprehensive Toxicology 498 529 .
Magnus T. Dillon & Kevin J. Harrington. 2018. Targeting the DNA Damage Response for Anti-Cancer Therapy. Targeting the DNA Damage Response for Anti-Cancer Therapy 99 127 .
Nicola Curtin & John Pollard. 2018. Targeting the DNA Damage Response for Anti-Cancer Therapy. Targeting the DNA Damage Response for Anti-Cancer Therapy 63 97 .
Ruitao Zhang, Huirong Shi, Fang Ren, Minghui Zhang, Pengcheng Ji, Wenwen Wang & Chuanna Liu. (2017) The aberrant upstream pathway regulations of CDK1 protein were implicated in the proliferation and apoptosis of ovarian cancer cells. Journal of Ovarian Research 10:1.
Crossref

Displaying 200 of 789 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.