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Review

Clinical development of liposome-based drugs: formulation, characterization, and therapeutic efficacy

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Pages 49-60 | Published online: 30 Dec 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (57)

So-Jung Kim, Nidhi Puranik, Dhananjay Yadav, Jun-O Jin & Peter CW Lee. (2023) Lipid Nanocarrier-Based Drug Delivery Systems: Therapeutic Advances in the Treatment of Lung Cancer. International Journal of Nanomedicine 18, pages 2659-2676.
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Shantanu Pande. (2023) Liposomes for drug delivery: review of vesicular composition, factors affecting drug release and drug loading in liposomes. Artificial Cells, Nanomedicine, and Biotechnology 51:1, pages 428-440.
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Malak El Sabeh, Kathleen L. Vincent, Sadia Afrin, Massoud Motamedi, Jamal Saada, Jinping Yang, Bulent Ozpolat, Gokhan S. Kilic & Mostafa A. Borahay. (2022) Simvastatin-loaded liposome nanoparticles treatment for uterine leiomyoma in a patient-derived xenograft mouse model: a pilot study. Journal of Obstetrics and Gynaecology 42:6, pages 2139-2143.
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Yu. A. Tereshkina, T. I. Torkhovskaya, E. G. Tikhonova, L. V. Kostryukova, M. A. Sanzhakov, E. I. Korotkevich, Yu. Yu. Khudoklinova, N. A. Orlova & E. F. Kolesanova. (2022) Nanoliposomes as drug delivery systems: safety concerns. Journal of Drug Targeting 30:3, pages 313-325.
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Tanzeel Ur Rehman & Kaitlin M. Bratlie. (2022) Improving selective targeting to cancer-associated fibroblasts by modifying liposomes with arginine based materials. Journal of Drug Targeting 30:1, pages 94-107.
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Luisa L. Palmese, Ming Fan, Rebecca A. Scott, Huaping Tan & Kristi L. Kiick. (2021) Multi-stimuli-responsive, liposome-crosslinked poly(ethylene glycol) hydrogels for drug delivery. Journal of Biomaterials Science, Polymer Edition 32:5, pages 635-656.
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Joydeb Majumder & Tamara Minko. (2021) Multifunctional and stimuli-responsive nanocarriers for targeted therapeutic delivery. Expert Opinion on Drug Delivery 18:2, pages 205-227.
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Claire H. Masterson, Sean D. McCarthy, Daniel O’Toole & John G. Laffey. (2020) The role of cells and their products in respiratory drug delivery: the past, present, and future. Expert Opinion on Drug Delivery 17:12, pages 1689-1702.
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C. Has & P. Sunthar. (2020) A comprehensive review on recent preparation techniques of liposomes. Journal of Liposome Research 30:4, pages 336-365.
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Anastasia Darwitan, Yang Fei Tan, Yee Shan Wong, Anu Maashaa Nedumaran, Bertrand Czarny & Subbu Venkatraman. (2020) Targeting efficiency of nanoliposomes on atherosclerotic foam cells: polyethylene glycol-to-ligand ratio effects. Expert Opinion on Drug Delivery 17:8, pages 1165-1176.
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Jing Xing, Xiquan Zhang, Zhe Wang, Huanqing Zhang, Peng Chen, Gaoxin Zhou, Chunlong Sun, Ning Gu & Min Ji. (2019) Novel lipophilic SN38 prodrug forming stable liposomes for colorectal carcinoma therapy. International Journal of Nanomedicine 14, pages 5201-5213.
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Henry Lujan, Wezley C Griffin, Joseph H Taube & Christie M Sayes. (2019) Synthesis and characterization of nanometer-sized liposomes for encapsulation and microRNA transfer to breast cancer cells. International Journal of Nanomedicine 14, pages 5159-5173.
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Yuk-Wah Tsang, Kwan-Hwa Chi, Cheng-Chung Huang, Mau-Shin Chi, Hsin-Chien Chiang, Kai-Lin Yang, Wen-Tyng Li & Yu-Shan Wang. (2019) Modulated electro-hyperthermia-enhanced liposomal drug uptake by cancer cells. International Journal of Nanomedicine 14, pages 1269-1279.
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Ludger M. Ickenstein & Patrick Garidel. (2019) Lipid-based nanoparticle formulations for small molecules and RNA drugs. Expert Opinion on Drug Delivery 16:11, pages 1205-1226.
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Yongju He, Liangyu Luo, Shuquan Liang, Mengqiu Long & Hui Xu. (2019) Influence of probe-sonication process on drug entrapment efficiency of liposomes loaded with a hydrophobic drug. International Journal of Polymeric Materials and Polymeric Biomaterials 68:4, pages 193-197.
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Chenchen Bing, Pratik Patel, Robert M. Staruch, Sumbul Shaikh, Joris Nofiele, Michelle Wodzak Staruch, Debra Szczepanski, Noelle S. Williams, Theodore Laetsch & Rajiv Chopra. (2019) Longer heating duration increases localized doxorubicin deposition and therapeutic index in Vx2 tumors using MR-HIFU mild hyperthermia and thermosensitive liposomal doxorubicin. International Journal of Hyperthermia 36:1, pages 195-202.
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Faheem Maqbool, Peter M. Moyle, Madeleine S. A. Tan, Kristofer J. Thurecht & James R. Falconer. (2018) Preparation of albendazole-loaded liposomes by supercritical carbon dioxide processing. Artificial Cells, Nanomedicine, and Biotechnology 46:sup3, pages 1186-1192.
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Yuping Wei, Liang Ma, Liang Zhang & Xia Xu. (2017) Noncovalent interaction-assisted drug delivery system with highly efficient uptake and release of paclitaxel for anticancer therapy. International Journal of Nanomedicine 12, pages 7039-7051.
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Xin Jin, Qing Yang & Youwen Zhang. (2017) Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer. International Journal of Nanomedicine 12, pages 5109-5118.
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Have Aliu, Carola Rask, Jens Brimnes & Thomas Lars Andresen. (2017) Enhanced efficacy of sublingual immunotherapy by liposome-mediated delivery of allergen. International Journal of Nanomedicine 12, pages 8377-8388.
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Nataliia Beztsinna, Yoanna Tsvetkova, Jithin Jose, Boutayna Rhourri-Frih, Wa’el Al Rawashdeh, Twan Lammers, Fabian Kiessling & Isabelle Bestel. (2017) Photoacoustic imaging of tumor targeting with riboflavin-functionalized theranostic nanocarriers. International Journal of Nanomedicine 12, pages 3813-3825.
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Rebecca L Ball, Palak Bajaj & Kathryn A Whitehead. (2017) Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization. International Journal of Nanomedicine 12, pages 305-315.
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Mengjie Rui, Yang Qu, Tong Gao, Yanru Ge, Chunlai Feng & Ximing Xu. (2017) Simultaneous delivery of anti-miR21 with doxorubicin prodrug by mimetic lipoprotein nanoparticles for synergistic effect against drug resistance in cancer cells. International Journal of Nanomedicine 12, pages 217-237.
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Matthias Augustin, Lisa Goepel, Arnd Jacobi, Bjoern Bosse, Stefan Mueller & Michael Hopp. (2017) Efficacy and tolerability of liposomal polyvinylpyrrolidone-iodine hydrogel for the localized treatment of chronic infective, inflammatory, dermatoses: an uncontrolled pilot study. Clinical, Cosmetic and Investigational Dermatology 10, pages 373-384.
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Elaine L. Ferguson, Anna Scomparin, Hanna Hailu & Ronit Satchi-Fainaro. (2017) HPMA copolymer–phospholipase C and dextrin–phospholipase A2 as model triggers for polymer enzyme liposome therapy (PELT). Journal of Drug Targeting 25:9-10, pages 818-828.
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Chao Liu, Haiyan Gao, Peng Lv, Jingyi Liu & Gang Liu. (2017) Extracellular vesicles as an efficient nanoplatform for the delivery of therapeutics. Human Vaccines & Immunotherapeutics 13:11, pages 2678-2687.
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Min Dai, Cong Wu, Hong-Ming Fang, Li Li, Jia-Bao Yan, Dan-Lin Zeng & Tao Zou. (2017) Thermo-responsive magnetic liposomes for hyperthermia-triggered local drug delivery. Journal of Microencapsulation 34:4, pages 408-415.
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Jun Chen, Junhong Yao, Zhuyue Ma, Pei Peng, Shanshan Lu, Yudong Hu, Fei Xu, Yang Yang & Xixiong Yang. (2017) Delivery of fluorescent-labeled cyclodextrin by liposomes: role of transferrin modification and phosphatidylcholine composition. Journal of Liposome Research 27:1, pages 21-31.
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Katsuyuki Kusuzaki, Takao Matsubara, Hiroaki Murata, Mariantonia Logozzi, Elisabetta Iessi, Rossella Di Raimo, Fabrizio Carta, Claudiu T. Supuran & Stefano Fais. (2017) Natural extracellular nanovesicles and photodynamic molecules: is there a future for drug delivery?. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 908-916.
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Tapan Kumar Shaw, Dipika Mandal, Goutam Dey, Murari Mohan Pal, Paramita Paul, Samrat Chakraborty, Kazi Asraf Ali, Biswajit Mukherjee, Amal Kumar Bandyopadhyay & Mahitosh Mandal. (2017) Successful delivery of docetaxel to rat brain using experimentally developed nanoliposome: a treatment strategy for brain tumor. Drug Delivery 24:1, pages 346-357.
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Karthik Siram, Gregory Marslin, Chellan Vijaya Raghavan, Krishnamoorthy Balakumar, Habibur Rahman & Gregory Franklin. (2016) A brief perspective on the diverging theories of lymphatic targeting with colloids. International Journal of Nanomedicine 11, pages 2867-2872.
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Claudia Zylberberg & Sandro Matosevic. (2016) Pharmaceutical liposomal drug delivery: a review of new delivery systems and a look at the regulatory landscape. Drug Delivery 23:9, pages 3319-3329.
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Gabriela Garrastazu Pereira, Amanda Jane Lawson, Francesca Buttini & Fabio Sonvico. (2016) Loco-regional administration of nanomedicines for the treatment of lung cancer. Drug Delivery 23:8, pages 2881-2896.
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Tessa van der Geest, Peter Laverman, Josbert M. Metselaar, Gert Storm & Otto C. Boerman. (2016) Radionuclide imaging of liposomal drug delivery. Expert Opinion on Drug Delivery 13:9, pages 1231-1242.
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Luís F. Neves, Jinghua Duan, Adrienne Voelker, Anil Khanal, Lacey McNally, Jill Steinbach-Rankins & Brian P. Ceresa. (2016) Preparation and optimisation of anionic liposomes for delivery of small peptides and cDNA to human corneal epithelial cells. Journal of Microencapsulation 33:4, pages 391-399.
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Ravi Doddapaneni, Ketan Patel, Ibtisam Hasan Owaid & Mandip Singh. (2016) Tumor neovasculature-targeted cationic PEGylated liposomes of gambogic acid for the treatment of triple-negative breast cancer. Drug Delivery 23:4, pages 1232-1241.
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Wei Zong, Ying Hu, Yingchun Su, Nan Luo, Xunan Zhang, Qingchuan Li & Xiaojun Han. (2016) Polydopamine-coated liposomes as pH-sensitive anticancer drug carriers. Journal of Microencapsulation 33:3, pages 257-262.
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Jordi Rello & Antonio Perez. (2016) Precision medicine for the treatment of severe pneumonia in intensive care. Expert Review of Respiratory Medicine 10:3, pages 297-316.
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Huei-Ling Huang, Pei-Hsuan Lu, Hung-Chih Yang, Gi-Da Lee, Han-Ru Li & Kuo-Chih Liao. (2015) Fiber-optic triggered release of liposome in vivo: implication of personalized chemotherapy. International Journal of Nanomedicine 10, pages 5171-5185.
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Xiaoli Feng, Aijie Chen, Yanli Zhang, Jianfeng Wang, Longquan Shao & Limin Wei. (2015) Central nervous system toxicity of metallic nanoparticles. International Journal of Nanomedicine 10, pages 4321-4340.
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Jun Zheng Goh, Sook Nai Tang, Hoe Siong Chiong, Yoke Keong Yong, Ahmad Zuraini & Muhammad Nazrul Hakim. (2015) Evaluation of antinociceptive activity of nanoliposome-encapsulated and free-form diclofenac in rats and mice. International Journal of Nanomedicine 10, pages 297-303.
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Giuseppina Bozzuto & Agnese Molinari. (2015) Liposomes as nanomedical devices. International Journal of Nanomedicine 10, pages 975-999.
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Edouard Alphandéry, Pierre Grand-Dewyse, Raphael Lefèvre, Chalani Mandawala & Mickael Durand-Dubief. (2015) Cancer therapy using nanoformulated substances: scientific, regulatory and financial aspects. Expert Review of Anticancer Therapy 15:10, pages 1233-1255.
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Michael E. Wagner & Syed S. H. Rizvi. (2015) Novel method of niosome generation using supercritical carbon dioxide part I: process mechanics. Journal of Liposome Research 25:4, pages 334-346.
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Terence E Hartnett, Andrea J O’Connor & Katharina Ladewig. (2015) Cubosomes and other potential ocular drug delivery vehicles for macromolecular therapeutics. Expert Opinion on Drug Delivery 12:9, pages 1513-1526.
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Wing-Hin Lee, Ching-Yee Loo, Daniela Traini & Paul M Young. (2015) Nano- and micro-based inhaled drug delivery systems for targeting alveolar macrophages. Expert Opinion on Drug Delivery 12:6, pages 1009-1026.
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Anthony Novell, Chantal Al Sabbagh, Jean-Michel Escoffre, Cédric Gaillard, Nicolas Tsapis, Elias Fattal & Ayache Bouakaz. (2015) Focused ultrasound influence on calcein-loaded thermosensitive stealth liposomes. International Journal of Hyperthermia 31:4, pages 349-358.
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Jae-Ho Lee, Shuai Shao, Kenneth T. Cheng, Jonathan F. Lovell & Chang H. Paik. (2015) 99mTc-labeled porphyrin–lipid nanovesicles. Journal of Liposome Research 25:2, pages 101-106.
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Yifei Huang, Tan Yang, Wendian Zhang, Yao Lu, Peng Ye, Guang Yang, Bin Li, Shibo Qi, Yong Liu, Xingxing He, Robert J Lee, Chuanrui Xu & Guangya Xiang. (2014) A novel hydrolysis-resistant lipophilic folate derivative enables stable delivery of targeted liposomes in vivo. International Journal of Nanomedicine 9, pages 4581-4595.
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Anita Hafner, Jasmina Lovrić, Gorana Perina Lakoš & Ivan Pepić. (2014) Nanotherapeutics in the EU: an overview on current state and future directions. International Journal of Nanomedicine 9, pages 1005-1023.
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Joy Wolfram, Krishna Suri, Yi Huang, Roberto Molinaro, Carlotta Borsoi, Bronwyn Scott, Kathryn Boom, Donatella Paolino, Massimo Fresta, Jianghua Wang, Mauro Ferrari, Christian Celia & Haifa Shen. (2014) Evaluation of anticancer activity of celastrol liposomes in prostate cancer cells. Journal of Microencapsulation 31:5, pages 501-507.
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Nivesh K. Mittal, Himanshu Bhattacharjee, Bivash Mandal, Pavan Balabathula, Laura A. Thoma & George C. Wood. (2014) Targeted liposomal drug delivery systems for the treatment of B cell malignancies. Journal of Drug Targeting 22:5, pages 372-386.
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Rajesh Mukthavaram, Pengfei Jiang, Rohit Saklecha, Dmitri Simberg, Ila Sri Bharati, Natsuko Nomura, Ying Chao, Sandra Pastorino, Sandeep C Pingle, Valentina Fogal, Wolf Wrasidlo, Milan Makale & Santosh Kesari. (2013) High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor response profile. International Journal of Nanomedicine 8, pages 3991-4006.
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Helene Kettiger, Angela Schipanski, Peter Wick & Jörg Huwyler. (2013) Engineered nanomaterial uptake and tissue distribution: from cell to organism. International Journal of Nanomedicine 8, pages 3255-3269.
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Tyler Davis & Sherif S Farag. (2013) Treating relapsed or refractory Philadelphia chromosome-negative acute lymphoblastic leukemia: liposome-encapsulated vincristine. International Journal of Nanomedicine 8, pages 3479-3488.
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Radhakrishnan Sridhar & Seeram Ramakrishna. (2013) Electrosprayed nanoparticles for drug delivery and pharmaceutical applications. Biomatter 3:3.
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Zhiping Zhang, Lin Mei & Si-Shen Feng. (2013) Paclitaxel drug delivery systems. Expert Opinion on Drug Delivery 10:3, pages 325-340.
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