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Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers

Pages 1794-1809 | Published online: 01 Jun 2011

Keep up to date with the latest research on this topic with citation updates for this article.

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Pin Fu, Fuchun Chen, Qi Pan, Xianda Zhao, Chen Zhao, William Chi-Shing Cho & Honglei Chen. (2017) The different functions and clinical significances of caveolin-1 in human adenocarcinoma and squamous cell carcinoma. OncoTargets and Therapy 10, pages 819-835.
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Michael P. Lisanti, Ubaldo E. Martinez-Outschoorn & Federica Sotgia. (2013) Oncogenes induce the cancer-associated fibroblast phenotype: Metabolic symbiosis and “fibroblast addiction” are new therapeutic targets for drug discovery. Cell Cycle 12:17, pages 2723-2732.
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Diana Martins, Francisco Beça, Bárbara Sousa, Fátima Baltazar, Joana Paredes & Fernando Schmitt. (2013) Loss of caveolin-1 and gain of MCT4 expression in the tumor stroma: Key events in the progression from an in situ to an invasive breast carcinoma. Cell Cycle 12:16, pages 2684-2690.
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Ubaldo E Martinez-Outschoorn, Joseph M Curry, Ying-Hui Ko, Zhao Lin, Madalina Tuluc, David Cognetti, Ruth C Birbe, Edmund Pribitkin, Alessandro Bombonati, Richard G Pestell, Anthony Howell, Federica Sotgia & Michael P Lisanti. (2013) Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment. Cell Cycle 12:16, pages 2580-2597.
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Paola Avena, Wanda Anselmo, Chenguang Wang, Richard G. Pestell, Rebecca S. Lamb, Ivan Casaburi, Sebastiano Andò, Ubaldo E. Martinez-Outschoorn & Michael P. Lisanti. (2013) Compartment-specific activation of PPARγ governs breast cancer tumor growth, via metabolic reprogramming and symbiosis. Cell Cycle 12:9, pages 1360-1370.
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Rosa Sanchez-Alvarez, Ubaldo E. Martinez-Outschoorn, Zhao Lin, Rebecca Lamb, James Hulit, Anthony Howell, Federica Sotgia, Emanuel Rubin & Michael P. Lisanti. (2013) Ethanol exposure induces the cancer-associated fibroblast phenotype and lethal tumor metabolism. Cell Cycle 12:2, pages 289-301.
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Rosa Sanchez-Alvarez, Ubaldo E. Martinez-Outschoorn, Rebecca Lamb, James Hulit, Anthony Howell, Ricardo Gandara, Marina Sartini, Emanuel Rubin, Michael P. Lisanti & Federica Sotgia. (2013) Mitochondrial dysfunction in breast cancer cells prevents tumor growth. Cell Cycle 12:1, pages 172-182.
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Federica Sotgia, Diana Whitaker-Menezes, Ubaldo E. Martinez-Outschoorn, Ahmed F. Salem, Aristotelis Tsirigos, Rebecca Lamb, Sharon Sneddon, James Hulit, Anthony Howell & Michael P. Lisanti. (2012) Mitochondria “fuel” breast cancer metabolism: Fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells. Cell Cycle 11:23, pages 4390-4401.
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Ahmed F. Salem, Anthony Howell, Marina Sartini, Federica Sotgia & Michael P. Lisanti. (2012) Downregulation of stromal BRCA1 drives breast cancer tumor growth via upregulation of HIF-1α, autophagy and ketone body production. Cell Cycle 11:22, pages 4167-4173.
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Ahmed F. Salem, Diana Whitaker-Menezes, Zhao Lin, Ubaldo E. Martinez-Outschoorn, Herbert B. Tanowitz, Mazhar Salim Al-Zoubi, Anthony Howell, Richard G. Pestell, Federica Sotgia & Michael P. Lisanti. (2012) Two-compartment tumor metabolism: Autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells. Cell Cycle 11:13, pages 2545-2559.
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Claudia Capparelli, Carmela Guido, Diana Whitaker-Menezes, Gloria Bonuccelli, Renee Balliet, Timothy G. Pestell, Allison F. Goldberg, Richard G. Pestell, Anthony Howell, Sharon Sneddon, Ruth Birbe, Aristotelis Tsirigos, Ubaldo Martinez-Outschoorn, Federica Sotgia & Michael P. Lisanti. (2012) Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis, via glycolysis and ketone production. Cell Cycle 11:12, pages 2285-2302.
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Agnieszka K. Witkiewicz, Diana Whitaker-Menezes, Abhijit Dasgupta, Nancy J. Philp, Zhao Lin, Ricardo Gandara, Sharon Sneddon, Ubaldo E. Martinez-Outschoorn, Federica Sotgia & Michael P. Lisanti. (2012) Using the “reverse Warburg effect” to identify high-risk breast cancer patients. Cell Cycle 11:6, pages 1108-1117.
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Ubaldo E. Martinez-Outschoorn, Richard G. Pestell, Anthony Howell, Mark L. Tykocinski, Fnu Nagajyothi, Fabiana S. Machado, Herbert B. Tanowitz, Federica Sotgia & Michael P. Lisanti. (2011) Energy transfer in "parasitic" cancer metabolism. Cell Cycle 10:24, pages 4208-4216.
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Barbara Chiavarina , Diana Whitaker-Menezes, Ubaldo E. Martinez-Outschoorn, Agnieszka K. Witkiewicz, Ruth Birbe, Anthony Howell, Richard G. Pestell, Johanna Smith, Rene Daniel, Federica Sotgia & Michael P. Lisanti. (2011) Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth. Cancer Biology & Therapy 12:12, pages 1101-1113.
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Renee M. Balliet, Claudia Capparelli, Carmela Guido, Timothy G. Pestell, Ubaldo E. Martinez-Outschoorn, Zhao Lin, Diana Whitaker-Menezes, Barbara Chiavarina, Richard G. Pestell, Anthony Howell, Federica Sotgia & Michael P. Lisanti. (2011) Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth. Cell Cycle 10:23, pages 4065-4073.
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Diana Whitaker-Menezes, Ubaldo E. Martinez-Outschoorn, Neal Flomenberg, Ruth Birbe, Agnieszka K. Witkiewicz, Anthony Howell, Stephanos Pavlides, Aristotelis Tsirigos, Adam Ertel, Richard G. Pestell, Paolo Broda, Carlo Minetti, Michael P. Lisanti & Federica Sotgia. (2011) Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ. Cell Cycle 10:23, pages 4047-4064.
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Michael P Lisanti, Ubaldo E. Martinez-Outschoorn, Zhao Lin, Stephanos Pavlides, Diana Whitaker-Menezes, Richard G. Pestell, Anthony Howell & Federica Sotgia. (2011) Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis. Cell Cycle 10:15, pages 2440-2449.
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Ubaldo E. Martinez-Outschoorn, Zhao Lin , Casey Trimmer, Neal Flomenberg, Chenguang Wang, Stephanos Pavlides, Richard G. Pestell, Anthony Howell, Federica Sotgia & Michael P Lisanti. (2011) Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect. Cell Cycle 10:15, pages 2504-2520.
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Ubaldo E. Martinez-Outschoorn, Zhao Lin, Ying-Hui Ko, Allison Goldberg, Neal Flomenberg, Chenguang Wang, Stephanos Pavlides, Richard G. Pestell, Anthony Howell, Federica Sotgia & Michael P. Lisanti. (2011) Understanding the metabolic basis of drug resistance. Cell Cycle 10:15, pages 2521-2528.
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Michael P Lisanti, Ubaldo E. Martinez-Outschoorn, Stephanos Pavlides, Diana Whitaker-Menezes, Richard G. Pestell, Anthony Howell & Federica Sotgia. (2011) Accelerated aging in the tumor microenvironment. Cell Cycle 10:13, pages 2059-2063.
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