Cancer Biology & Therapy, Volume 10, Issue 6 (2010)

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Cancer Biology & Therapy, Volume 10, Issue 6 (2010)

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Review

Review Article
The role of microenvironment in testicular germ cell tumors
Alejandro Díez-Torre, Unai Silván, María Díaz-Núñez & Juan Arechaga
Pages: 529-536
Published online: 15 Sep 2010
AbstractforThe role of microenvironment in testicular germ cell tumors | PDF (1.2 MB)
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Review Article
Understanding the "lethal" drivers of tumor-stroma co-evolution
Emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor microenvironment
Michael P. Lisanti, Ubaldo E. Martinez-Outschoorn, Barbara Chiavarina, Stephanos Pavlides, Diana Whitaker-Menezes, Aristotelis Tsirigos, Agnieszka K. Witkiewicz, Zhao Lin, Renee M. Balliet, Anthony Howell & Federica Sotgia
Pages: 537-542
Published online: 15 Sep 2010
AbstractforUnderstanding the "lethal" drivers of tumor-stroma co-evolution | Full Text | References | PDF (1.5 MB)
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Clinical Study

Article
Metronomic administration of Zoledronic Acid and Taxotere combination in castration resistant prostate cancer patients: Phase I ZANTE trial
Gaetano Facchini, Michele Caraglia, Alessandro Morabito, Monica Marra, Maria C. Piccirillo, Anna M. Bochicchio, Stefano Striano, Luigi Marra, Guglielmo Nasti, Ettore Ferrara, Giovanni Vitale, Davide Gentilini, Anna Tortoriello, Alfonso Catalano, Alfredo Budillon, Franco Perrone & Rosario V. Iaffaioli
Pages: 543-548
Published online: 15 Sep 2010
AbstractforMetronomic administration of Zoledronic Acid and Taxotere combination in castration resistant prostate cancer patients: Phase I ZANTE trial | PDF (734 KB)
  • 543 Views
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Article
High levels of fatty acid synthase expression in esophageal cancers represent a potential target for therapy
Hajime Orita, Jonathan Coulter, Ellen Tully, Masaaki Abe, Elizabeth Montgomery, Hector Alvarez, Koichi Sato, Okio Hino, Yoshiaki Kajiyama, Masahiko Tsurumaru & Edward Gabrielson
Pages: 549-554
Published online: 15 Sep 2010
AbstractforHigh levels of fatty acid synthase expression in esophageal cancers represent a potential target for therapy | PDF (1.6 MB)
  • 542 Views
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Research Paper

Article
ErbB3 expression promotes tumorigenesis in pancreatic adenocarcinoma
J. Spencer Liles, J. Pablo Arnoletti, Ching-Wei D. Tzeng, J. Harrison Howard, Andrew V. Kossenkov, Peter Kulesza, Martin J. Heslin & Andrey Frolov
Pages: 555-563
Published online: 15 Sep 2010
AbstractforErbB3 expression promotes tumorigenesis in pancreatic adenocarcinoma | Full Text | References | PDF (1.6 MB)
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Commentary

ERBB3
Multifunctional enabler or primary actor in pancreatic cancer?
Ralf Landgraf
Pages: 564-566
Published online: 15 Sep 2010
AbstractforERBB3 | Full Text | References | PDF (278.3 KB)
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Research Paper

Article
Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma
Evidence for p53-transcription-dependent and -independent pathways
Manujendra N. Saha, Hua Jiang & Hong Chang
Pages: 567-578
Published online: 15 Sep 2010
AbstractforMolecular mechanisms of nutlin-induced apoptosis in multiple myeloma | Full Text | References | PDF (3.6 MB) | Supplemental
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Commentary

Nutlin's two roads toward apoptosis
Qi Zhang & Hua Lu
Pages: 579-581
Published online: 15 Sep 2010
AbstractforNutlin's two roads toward apoptosis | Full Text | References | PDF (278.1 KB)
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Research Paper

Article
Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM)
Hannah Carter, Josue Samayoa, Ralph H. Hruban & Rachel Karchin
Pages: 582-587
Published online: 15 Sep 2010
AbstractforPrioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM) | Full Text | References | PDF (638.8 KB) | Supplemental
  • 1905 Views
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Commentary

Driver mutations
A roadmap for getting close and personal in pancreatic cancer
Murray Korc
Pages: 588-591
Published online: 15 Sep 2010
AbstractforDriver mutations | Full Text | References | PDF (1 MB)
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Research Paper

Article
Endogenous expression of proteases in colon cancer cells facilitate influenza A viruses mediated oncolysis
Sanda Sturlan, Stefan Stremitzer, Suzann Bauman, Monika Sachet, Markus Wolschek, Tanja Ruthsatz, Andrej Egorov & Michael Bergmann
Pages: 592-599
Published online: 15 Sep 2010
AbstractforEndogenous expression of proteases in colon cancer cells facilitate influenza A viruses mediated oncolysis | PDF (1 MB)
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Article
ITF2 is a target of CXCR4 in MDA-MB-231 breast cancer cells and is associated with reduced survival in estrogen receptor-negative breast cancer
Hitesh Appaiah, Poornima Bhat-Nakshatri, Rutika Mehta, Mangesh Thorat, Sunil Badve & Harikrishna Nakshatri
Pages: 600-614
Published online: 15 Sep 2010
AbstractforITF2 is a target of CXCR4 in MDA-MB-231 breast cancer cells and is associated with reduced survival in estrogen receptor-negative breast cancer | PDF (7.5 MB) | Supplemental
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Commentary

CXCR4 signaling identifies a role for IFT2 in ER-negative breast cancers
Jonathan R. Brody & Agnieszka K. Witkiewicz
Pages: 615-616
Published online: 15 Sep 2010
AbstractforCXCR4 signaling identifies a role for IFT2 in ER-negative breast cancers | PDF (277.8 KB)
  • 181 Views
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Research Paper

Article
WNT5A antagonizes WNT/β-catenin signaling and is frequently silenced by promoter CpG methylation in esophageal squamous cell carcinoma
Jisheng Li, Jianming Ying, Yichao Fan, Longtao Wu, Ying Ying, Anthony TC Chan, Gopesh Srivastava & Qian Tao
Pages: 617-624
Published online: 15 Sep 2010
AbstractforWNT5A antagonizes WNT/β-catenin signaling and is frequently silenced by promoter CpG methylation in esophageal squamous cell carcinoma | PDF (1.9 MB)
  • 782 Views
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Article
A non-coding cationic lipid DNA complex produces lasting anti-leukemic effects
Nikki Keasey, Zachary Herse, Stella Chang, Denny H. Liggitt, Jeffery Fairman, Marla Lay & David F. Claxton
Pages: 625-631
Published online: 15 Sep 2010
AbstractforA non-coding cationic lipid DNA complex produces lasting anti-leukemic effects | Full Text | References | PDF (1.3 MB)
  • 370 Views
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Article
Stathmin is involved in arsenic trioxide-induced apoptosis in human cervical cancer cell lines via PI3K linked signal pathway
Xi Wang, Ji-Hong Ren, Fang Lin, Jun-Xia Wei, Min Long, Lin Yan & Hui-Zhong Zhang
Pages: 632-643
Published online: 15 Sep 2010
AbstractforStathmin is involved in arsenic trioxide-induced apoptosis in human cervical cancer cell lines via PI3K linked signal pathway | PDF (6.4 MB)
  • 435 Views
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Article
Therapeutic targeting of Trk supresses tumor proliferation and enhances cisplatin activity in HNSCC
Turker Yilmaz, Tilahun Jiffar, Gabriel de la Garza, Heather Lin, Terry MacIntyre, Jeffrey L. Brown, Jeffrey N. Myers & Michael E. Kupferman
Pages: 644-653
Published online: 15 Sep 2010
AbstractforTherapeutic targeting of Trk supresses tumor proliferation and enhances cisplatin activity in HNSCC | Full Text | References | PDF (4.8 MB) | Supplemental
  • 816 Views
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