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Review

Cellular responses to hyperthermia (40–46°C): Cell killing and molecular events

Pages 3-15 | Received 26 Sep 2007, Accepted 25 Oct 2007, Published online: 09 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Atsushi Enomoto, Takemichi Fukasawa, Hiroshi Terunuma, Keiichi Nakagawa, Ayumi Yoshizaki, Shinichi Sato, Noriko Hosoya & Kiyoshi Miyagawa. (2024) Deregulated JNK signaling enhances apoptosis during hyperthermia. International Journal of Hyperthermia 41:1.
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Leonardo Bianchi, Fabiana Cavarzan, Lucia Ciampitti, Matteo Cremonesi, Francesca Grilli & Paola Saccomandi. (2022) Thermophysical and mechanical properties of biological tissues as a function of temperature: a systematic literature review. International Journal of Hyperthermia 39:1, pages 297-340.
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Atsushi Enomoto, Takemichi Fukasawa, Hiroshi Terunuma, Keiichi Nakagawa, Ayumi Yoshizaki, Shinichi Sato & Kiyoshi Miyagawa. (2022) Decrease in MAP3Ks expression enhances the cell death caused by hyperthermia. International Journal of Hyperthermia 39:1, pages 200-208.
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Kameel Zuniga, Manasa Gadde, Jacob Scheftel, Kris Senecal, Erik Cressman, Mark Van Dyke & Marissa Nichole Rylander. (2021) Collagen/kerateine multi-protein hydrogels as a thermally stable extracellular matrix for 3D in vitro models. International Journal of Hyperthermia 38:1, pages 830-845.
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M. H. A Groen, F. J. B Slieker, A. Vink, G. J. de Borst, M. V. Simons, E. S. Ebbini, P. A. Doevendans, C. E. V. B. Hazenberg & R. van Es. (2020) Safety and feasibility of arterial wall targeting with robot-assisted high intensity focused ultrasound: a preclinical study. International Journal of Hyperthermia 37:1, pages 903-912.
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Alexander Rühle, Andreas Thomsen, Rainer Saffrich, Maren Voglstätter, Birgit Bieber, Tanja Sprave, Patrick Wuchter, Peter Vaupel, Peter E. Huber, Anca-Ligia Grosu & Nils H. Nicolay. (2020) Multipotent mesenchymal stromal cells are sensitive to thermic stress – potential implications for therapeutic hyperthermia. International Journal of Hyperthermia 37:1, pages 430-441.
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Guoliang Qiao, Xiaoli Wang, Xinna Zhou, Michael A. Morse, Jiangping Wu, Shuo Wang, Yuguang Song, Ni Jiang, Yanjie Zhao, Lei Zhou, Jing Zhao, Yan Di, Lihong Zhu, Amy Hobeika, Jun Ren & Herbert Kim Lyerly. (2019) Immune correlates of clinical benefit in a phase I study of hyperthermia with adoptive T cell immunotherapy in patients with solid tumors. International Journal of Hyperthermia 36:sup1, pages 74-82.
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George Lagoumintzis, Andreas Andrikopoulos, Adam Adamopoulos, Ioannis Seimenis & Constantinos Koutsojannis. (2019) Microwave diathermy induces mitogen-activated protein kinases and tumor necrosis factor-α in cultured human monocytes. Electromagnetic Biology and Medicine 38:3, pages 218-229.
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M. T. Ladjimi, D. Labavić, M. Guilbert, F. Anquez, A. Pruvost, E. Courtade, B. Pfeuty & Q. Thommen. (2019) Dynamical thermal dose models and dose time-profile effects. International Journal of Hyperthermia 36:1, pages 720-728.
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Petros X. E. Mouratidis, Ian Rivens, John Civale, Richard Symonds-Tayler & Gail ter Haar. (2019) ‘Relationship between thermal dose and cell death for “rapid” ablative and “slow” hyperthermic heating’. International Journal of Hyperthermia 36:1, pages 228-242.
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Nathalie van den Tempel, Hanny Odijk, Netteke van Holthe, Kishan Naipal, Anja Raams, Berina Eppink, Dik C. van Gent, Jose Hardillo, Gerda M. Verduijn, Jan C. Drooger, Gerard C. van Rhoon, Dineke (H.) P.M. Smedts, Helena C. van Doorn, Joost L. Boormans, Agnes Jager, Martine Franckena & Roland Kanaar. (2018) Heat-induced BRCA2 degradation in human tumours provides rationale for hyperthermia-PARP-inhibitor combination therapies. International Journal of Hyperthermia 34:4, pages 407-414.
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Zahra Sobhani, Mohammad Ali Behnam, Farzin Emami, Amirreza Dehghanian & Iman Jamhiri. (2017) Photothermal therapy of melanoma tumor using multiwalled carbon nanotubes. International Journal of Nanomedicine 12, pages 4509-4517.
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Peng Li, Qing-Li Zhao, Paras Jawaid, Mati Ur Rehman, Kanwal Ahmed, Hiroaki Sakurai & Takashi Kondo. (2017) Enhancement of hyperthermia-induced apoptosis by 5Z-7-oxozeaenol, a TAK1 inhibitor, in Molt-4 cells. International Journal of Hyperthermia 33:4, pages 411-418.
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Irena Adkins, Lenka Sadilkova, Nada Hradilova, Jakub Tomala, Marek Kovar & Radek Spisek. (2017) Severe, but not mild heat-shock treatment induces immunogenic cell death in cancer cells. OncoImmunology 6:5.
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Maxime Lafond, Florent Aptel, Jean-Louis Mestas & Cyril Lafon. (2017) Ultrasound-mediated ocular delivery of therapeutic agents: a review. Expert Opinion on Drug Delivery 14:4, pages 539-550.
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Akihisa Takahashi, Eiichiro Mori, Yosuke Nakagawa, Atsuhisa Kajihara, Tadaaki Kirita, Douglas L. Pittman, Masatoshi Hasegawa & Takeo Ohnishi. (2017) Homologous recombination preferentially repairs heat-induced DNA double-strand breaks in mammalian cells. International Journal of Hyperthermia 33:3, pages 336-342.
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Chandra P Epperla, Oliver Y Chen & Huan-Cheng Chang. (2016) Gold/Diamond Nanohybrids May Reveal How Hyperlocalized Hyperthermia Kills Cancer Cells. Nanomedicine 11:5, pages 443-445.
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Gerard C. van Rhoon. (2016) Is CEM43 still a relevant thermal dose parameter for hyperthermia treatment monitoring?. International Journal of Hyperthermia 32:1, pages 50-62.
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Reihaneh Haghniaz, Rinku D Umrani & Kishore M Paknikar. (2015) Temperature-dependent and time-dependent effects of hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3: in vitro studies. International Journal of Nanomedicine 10, pages 1609-1623.
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Petros X.E. Mouratidis, Ian Rivens & Gail ter Haar. (2015) A study of thermal dose-induced autophagy, apoptosis and necroptosis in colon cancer cells. International Journal of Hyperthermia 31:5, pages 476-488.
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Mayra L. Sottile, Antonella D. Losinno, Mariel A. Fanelli, F. Darío Cuello-Carrión, M. Magdalena Montt-Guevara, Laura M. Vargas-Roig & Silvina B. Nadin. (2015) Hyperthermia effects on Hsp27 and Hsp72 associations with mismatch repair (MMR) proteins and cisplatin toxicity in MMR-deficient/proficient colon cancer cell lines. International Journal of Hyperthermia 31:5, pages 464-475.
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Maria Moros, Alfredo Ambrosone, Grazyna Stepien, Federica Fabozzi, Valentina Marchesano, Anna Castaldi, Angela Tino, Jesus M de la Fuente & Claudia Tortiglione. (2015) Deciphering Intracellular Events Triggered by Mild Magnetic Hyperthermia in Vitro and in Vivo. Nanomedicine 10:14, pages 2167-2183.
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Merlis P Alvarez-Berríos, Amalchi Castillo, Carlos Rinaldi & Madeline Torres-Lugo. (2014) Magnetic fluid hyperthermia enhances cytotoxicity of bortezomib in sensitive and resistant cancer cell lines. International Journal of Nanomedicine 9, pages 145-153.
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Amarnath Mukherjee, Mark Castanares, Mohammad Hedayati, Michele Wabler, Bruce Trock, Prakash Kulkarni, Ronald Rodriguez, Robert H Getzenberg, Theodore L DeWeese, Robert Ivkov & Shawn E Lupold. (2014) Monitoring Nanoparticle-Mediated Cellular Hyperthermia with A High-Sensitivity Biosensor. Nanomedicine 9:18, pages 2729-2743.
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Niloy R. Datta, Emsad Puric, Ralf Schneider, Damien C. Weber, Susanne Rogers & Stephan Bodis. (2014) Could hyperthermia with proton therapy mimic carbon ion therapy? Exploring a thermo-radiobiological rationale. International Journal of Hyperthermia 30:7, pages 524-530.
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Jun Zhao, Michael Wallace & Marites P Melancon. (2014) Cancer Theranostics with Gold Nanoshells. Nanomedicine 9:13, pages 2041-2057.
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Cora Wex, Anke Stoll, Marlen Fröhlich, Susann Arndt & Hans Lippert. (2014) Mechanics of fresh, frozen-thawed and heated porcine liver tissue. International Journal of Hyperthermia 30:4, pages 271-283.
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Madeline Torres-Lugo & Carlos Rinaldi. (2013) Thermal Potentiation of Chemotherapy by Magnetic Nanoparticles. Nanomedicine 8:10, pages 1689-1707.
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Chanchala D Kaddi, John H Phan & May D Wang. (2013) Computational Nanomedicine: Modeling of Nanoparticle-Mediated Hyperthermal Cancer Therapy. Nanomedicine 8:8, pages 1323-1333.
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John A. Pearce. (2013) Comparative analysis of mathematical models of cell death and thermal damage processes. International Journal of Hyperthermia 29:4, pages 262-280.
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Laura Martínez Maestro, Patricia Haro-González, M Carmen Iglesias-de la Cruz, Francisco SanzRodríguez, Ángeles Juarranz, José García Solé & Daniel Jaque. (2013) Fluorescent Nanothermometers Provide Controlled Plasmonic-Mediated Intracellular Hyperthermia. Nanomedicine 8:3, pages 379-388.
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Silvina B. Nadin, F. Darío Cuello-Carrión, Mayra L. Sottile, Daniel R. Ciocca & Laura M. Vargas-Roig. (2012) Effects of hyperthermia on Hsp27 (HSPB1), Hsp72 (HSPA1A) and DNA repair proteins hMLH1 and hMSH2 in human colorectal cancer hMLH1-deficient and hMLH1-proficient cell lines. International Journal of Hyperthermia 28:3, pages 191-201.
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Mark R. Brinton, Chad A. Tagge, Russell J. Stewart, Alfred K. Cheung, Yan-Ting E. Shiu & Douglas A. Christensen. (2012) Thermal sensitivity of endothelial cells on synthetic vascular graft material. International Journal of Hyperthermia 28:2, pages 163-174.
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Jianping Zhang, Abiche H. Dewilde, Paul Chinn, Allan Foreman, Stephen Barry, David Kanne & Susan J. Braunhut. (2011) Herceptin-directed nanoparticles activated by an alternating magnetic field selectively kill HER-2 positive human breast cells via hyperthermia. International Journal of Hyperthermia 27:7, pages 682-697.
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Roland Stone, Thomas Willi, Yitzhak Rosen, Olin Thompson Mefford & Frank Alexis. (2011) Targeted Magnetic Hyperthermia. Therapeutic Delivery 2:6, pages 815-838.
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Jin Yu, Peng Yin, Jingdong Yin, Fenghua Liu, Xiaoyu Zhu, Guiling Cheng, Kaijun Guo, Yulong Yin & Jianqin Xu. (2010) Involvement of ERK1/2 signalling and growth-related molecules’ expression in response to heat stress-induced damage in rat jejunum and IEC-6 cells. International Journal of Hyperthermia 26:6, pages 538-555.
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Joseph L. Roti Roti, Raj K. Pandita, Jason D. Mueller, Peter Novak, Eduardo G. Moros & Andrei Laszlo. (2010) Severe, short-duration (0–3 min) heat shocks (50–52°C) inhibit the repair of DNA damage. International Journal of Hyperthermia 26:1, pages 67-78.
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Munitta Muthana, Gabriele Multhoff & A. Graham Pockley. (2010) Tumour infiltrating host cells and their significance for hyperthermia. International Journal of Hyperthermia 26:3, pages 247-255.
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Rasa Zukiene, Zita Nauciene, Jolita Ciapaite & Vida Mildaz˘ienė. (2010) Acute temperature resistance threshold in heart mitochondria: Febrile temperature activates function but exceeding it collapses the membrane barrier. International Journal of Hyperthermia 26:1, pages 56-66.
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Andrei Laszlo & Ilona Fleischer. (2009) The heat-induced γ-H2AX response does not play a role in hyperthermic cell killing. International Journal of Hyperthermia 25:3, pages 199-209.
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