Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 31, Issue sup2 (2016)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 31, Issue sup2 (2016)

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Research Article

Article
Synthesis and carbonic anhydrase inhibitory activities of new thienyl-substituted pyrazoline benzenesulfonamides
Ebru Mete, Birnur Comez, Halise Inci Gul, Ilhami Gulcin & Claudiu T. Supuran
Pages: 1-5
Published online: 19 Jul 2016
AbstractforSynthesis and carbonic anhydrase inhibitory activities of new thienyl-substituted pyrazoline benzenesulfonamides | Full Text | References | PDF (190.3 KB)
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Article
Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1-phenylpyrazolo[3,4-d]pyrimidine derivatives
Rania B. Bakr, Amany A. Azouz & Khaled R. A. Abdellatif
Pages: 6-12
Published online: 22 May 2016
AbstractforSynthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1-phenylpyrazolo[3,4-d]pyrimidine derivatives | Full Text | References | PDF (319.8 KB)
  • 1238 Views
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Article
Design, synthesis and biological activity of 1H-indene-2-carboxamides as multi-targeted anti-Alzheimer agents
Mehmet Koca, Kadir Ozden Yerdelen, Baris Anil, Zeynep Kasap, Handan Sevindik, Ibrahim Ozyurek, Gulsen Gunesacar & Kubra Turkaydin
Pages: 13-23
Published online: 26 May 2016
AbstractforDesign, synthesis and biological activity of 1H-indene-2-carboxamides as multi-targeted anti-Alzheimer agents | Full Text | References | PDF (1.2 MB) | Supplemental
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Article
Synthesis, antimicrobial and anticonvulsant screening of small library of tetrahydro-2H-thiopyran-4-yl based thiazoles and selenazoles
Krzysztof Z. Łączkowski, Anna Biernasiuk, Angelika Baranowska-Łączkowska, Sylwia Zielińska, Kinga Sałat, Anna Furgała, Konrad Misiura & Anna Malm
Pages: 24-39
Published online: 19 May 2016
AbstractforSynthesis, antimicrobial and anticonvulsant screening of small library of tetrahydro-2H-thiopyran-4-yl based thiazoles and selenazoles | Full Text | References | PDF (698.7 KB)
  • 1428 Views
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Original Article

Article
Novel dipeptidyl hydroxamic acids that inhibit human and bacterial dipeptidyl peptidase III
Ana Cvitešić, Igor Sabljić, Janja Makarević & Marija Abramić
Pages: 40-45
Published online: 26 May 2016
AbstractforNovel dipeptidyl hydroxamic acids that inhibit human and bacterial dipeptidyl peptidase III | Full Text | References | PDF (456.6 KB) | Supplemental
  • 919 Views
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Research Article

Article
Effect of propolis in gastric disorders: inhibition studies on the growth of Helicobacter pylori and production of its urease
Nimet Baltas, Sengul Alpay Karaoglu, Cemre Tarakci & Sevgi Kolayli
Pages: 46-50
Published online: 27 May 2016
AbstractforEffect of propolis in gastric disorders: inhibition studies on the growth of Helicobacter pylori and production of its urease | Full Text | References | PDF (168.7 KB)
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Article
A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents
Jorge R. A. Diaz, Martín Fernández Baldo, Gustavo Echeverría, Héctor Baldoni, Daniela Vullo, Delia B. Soria, Claudiu T. Supuran & Gerardo E. Camí
Pages: 51-62
Published online: 27 May 2016
AbstractforA substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents | Full Text | References | PDF (1 MB) | Supplemental
  • 1554 Views
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Article
Three-component synthesis and carbonic anhydrase inhibitory properties of novel octahydroacridines incorporating sulfaguanidine scaffold
Ramazan Ulus, Muharrem Kaya, Damla Demir, Ekrem Tunca & Metin Bülbül
Pages: 63-69
Published online: 30 May 2016
AbstractforThree-component synthesis and carbonic anhydrase inhibitory properties of novel octahydroacridines incorporating sulfaguanidine scaffold | Full Text | References | PDF (407.4 KB) | Supplemental
  • 743 Views
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Original Article

Article
Soluble epoxide hydrolase inhibitory components from Rheum undulatum and in silico approach
Ah Reum Jo, Jang Hoon Kim, Xi-Tao Yan, Seo Young Yang & Young Ho Kim
Pages: 70-78
Published online: 23 Aug 2016
AbstractforSoluble epoxide hydrolase inhibitory components from Rheum undulatum and in silico approach | Full Text | References | PDF (2.5 MB) | Supplemental
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Research Article

Article
Synthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions
Fadime Özbey, Parham Taslimi, İlhami Gülçin, Ahmet Maraş, Süleyman Göksu & Claudiu T. Supuran
Pages: 79-85
Published online: 31 May 2016
AbstractforSynthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions | Full Text | References | PDF (376.7 KB)
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Article
Synthesis, structure elucidation, DNA-PK, PI3K, anti-platelet and anti-bacteria activity of linear 5, 6, and 10-substituted-2-morpholino-chromen-oxazine-dione and angular 3, 4, 6-substituted-8-morpholino-chromen-oxazine-2,10-dione
Rick Morrison & Jasim M. A. Al-Rawi
Pages: 86-95
Published online: 02 Jun 2016
AbstractforSynthesis, structure elucidation, DNA-PK, PI3K, anti-platelet and anti-bacteria activity of linear 5, 6, and 10-substituted-2-morpholino-chromen-oxazine-dione and angular 3, 4, 6-substituted-8-morpholino-chromen-oxazine-2,10-dione | Full Text | References | PDF (877.8 KB) | Supplemental
  • 1230 Views
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Article
Hybrid imidazole (benzimidazole)/pyridine (quinoline) derivatives and evaluation of their anticancer and antimycobacterial activity
Dorina Mantu, Vasilichia Antoci, Costel Moldoveanu, Gheorghita Zbancioc & Ionel I. Mangalagiu
Pages: 96-103
Published online: 02 Jun 2016
AbstractforHybrid imidazole (benzimidazole)/pyridine (quinoline) derivatives and evaluation of their anticancer and antimycobacterial activity | Full Text | References | PDF (384.5 KB) | Supplemental
  • 3507 Views
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Article
Synthesis and evaluation of antibacterial and antioxidant activity of novel 2-phenyl-quinoline analogs derivatized at position 4 with aromatically substituted 4H-1,2,4-triazoles
Donatella Verbanac, Ritu Malik, Mahesh Chand, Khushbu Kushwaha, Monika Vashist, Mario Matijašić, Višnja Stepanić, Mihaela Perić, Hana Čipčić Paljetak, Luciano Saso & Subhash C. Jain
Pages: 104-110
Published online: 19 Jun 2016
AbstractforSynthesis and evaluation of antibacterial and antioxidant activity of novel 2-phenyl-quinoline analogs derivatized at position 4 with aromatically substituted 4H-1,2,4-triazoles | Full Text | References | PDF (268.3 KB) | Supplemental
  • 2649 Views
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Article
Design, synthesis, and in vitro antiproliferative and kinase inhibitory effects of pyrimidinylpyrazole derivatives terminating with arylsulfonamido or cyclic sulfamide substituents
Mahmoud M. Gamal El-Din, Mohammed I. El-Gamal, Mohammed S. Abdel-Maksoud, Kyung Ho Yoo, Daejin Baek, Jungseung Choi, Huiseong Lee & Chang-Hyun Oh
Pages: 111-122
Published online: 02 Jun 2016
AbstractforDesign, synthesis, and in vitro antiproliferative and kinase inhibitory effects of pyrimidinylpyrazole derivatives terminating with arylsulfonamido or cyclic sulfamide substituents | Full Text | References | PDF (700.4 KB) | Supplemental
  • 1527 Views
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Article
In vitro characterization of TMPRSS2 inhibition in IPEC-J2 cells
Erzsebet Pászti-Gere, Eszter Czimmermann, Gabriella Ujhelyi, Peter Balla, Alexander Maiwald & Torsten Steinmetzer
Pages: 123-129
Published online: 09 Jun 2016
AbstractforIn vitro characterization of TMPRSS2 inhibition in IPEC-J2 cells | Full Text | References | PDF (526.8 KB)
  • 4015 Views
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Article
Microwave-assisted synthesis, anti-inflammatory and anti-proliferative activities of new maslinic acid derivatives bearing 1,5- and 1,4-disubstituted triazoles
Karim Chouaïb, Stéphanie Delemasure, Patrick Dutartre & Hichem Ben Jannet
Pages: 130-147
Published online: 19 Jul 2016
AbstractforMicrowave-assisted synthesis, anti-inflammatory and anti-proliferative activities of new maslinic acid derivatives bearing 1,5- and 1,4-disubstituted triazoles | Full Text | References | PDF (1.7 MB)
  • 1278 Views
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Article
Comparison of the ligand binding site of CYP2C8 with CYP26A1 and CYP26B1: a structural basis for the identification of new inhibitors of the retinoic acid hydroxylases
Robert S. Foti, Philippe Diaz & Dominique Douguet
Pages: 148-161
Published online: 17 Jul 2016
AbstractforComparison of the ligand binding site of CYP2C8 with CYP26A1 and CYP26B1: a structural basis for the identification of new inhibitors of the retinoic acid hydroxylases | Full Text | References | PDF (2.4 MB)
  • 1557 Views
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Article
Quercetin protects rat skeletal muscle from ischemia reperfusion injury
Fazile Nur Ekinci Akdemir, İlhami Gülçin, Berna Karagöz & Recep Soslu
Pages: 162-166
Published online: 16 Jun 2016
AbstractforQuercetin protects rat skeletal muscle from ischemia reperfusion injury | Full Text | References | PDF (178.9 KB)
  • 1961 Views
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Article
Reliability analysis and optimization of the consensus docking approach for the development of virtual screening studies
Giulio Poli, Adriano Martinelli & Tiziano Tuccinardi
Pages: 167-173
Published online: 17 Jun 2016
AbstractforReliability analysis and optimization of the consensus docking approach for the development of virtual screening studies | Full Text | References | PDF (419.2 KB) | Supplemental
  • 3163 Views
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Article
Design, synthesis and biological evaluation of N-(5-methyl-isoxazol-3-yl/1,3,4-thiadiazol-2-yl)-4-(3-substitutedphenylureido) benzenesulfonamides as human carbonic anhydrase isoenzymes I, II, VII and XII inhibitors
Chandra Bhushan Mishra, Shikha Kumari, Andrea Angeli, Simona Maria Monti, Martina Buonanno, Amresh Prakash, Manisha Tiwari & Claudiu T. Supuran
Pages: 174-179
Published online: 17 Jun 2016
AbstractforDesign, synthesis and biological evaluation of N-(5-methyl-isoxazol-3-yl/1,3,4-thiadiazol-2-yl)-4-(3-substitutedphenylureido) benzenesulfonamides as human carbonic anhydrase isoenzymes I, II, VII and XII inhibitors | Full Text | References | PDF (949.9 KB)
  • 1286 Views
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Article
A class of sulfonamides as carbonic anhydrase I and II inhibitors
Taner Gokcen, Ilhami Gulcin, Turan Ozturk & Ahmet C. Goren
Pages: 180-188
Published online: 29 Jun 2016
AbstractforA class of sulfonamides as carbonic anhydrase I and II inhibitors | Full Text | References | PDF (325.2 KB) | Supplemental
  • 2778 Views
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Short Communication

Rapid Communication
Antimicrobial activity, synergism and inhibition of germ tube formation by Crocus sativus-derived compounds against Candida spp.
Simone Carradori, Paola Chimenti, Marina Fazzari, Arianna Granese & Letizia Angiolella
Pages: 189-193
Published online: 10 May 2016
AbstractforAntimicrobial activity, synergism and inhibition of germ tube formation by Crocus sativus-derived compounds against Candida spp. | Full Text | References | PDF (216.7 KB)
  • 1878 Views
  • 36 CrossRef citations
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Rapid Communication
Miniature bovine pancreatic trypsin inhibitors (m-BPTIs) of the West Nile virus NS2B-NS3 protease
Melgious J. Y. Ang, Huichang A. Lim, Anders Poulsen, John Liang Kuan Wee, Fui Mee Ng, Joma Joy, Jeffrey Hill & C. S. Brian Chia
Pages: 194-200
Published online: 31 May 2016
AbstractforMiniature bovine pancreatic trypsin inhibitors (m-BPTIs) of the West Nile virus NS2B-NS3 protease | Full Text | References | PDF (2.2 MB)
  • 824 Views
  • 1 CrossRef citations
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Rapid Communication
Identification of Mycobacterium tuberculosis leucyl-tRNA synthetase (LeuRS) inhibitors among the derivatives of 5-phenylamino-2H-[1,2,4]triazin-3-one
Olga I. Gudzera, Andriy G. Golub, Volodymyr G. Bdzhola, Galyna P. Volynets, Oksana P. Kovalenko, Konstantin S. Boyarshin, Anna D. Yaremchuk, Mykola V. Protopopov, Sergiy M. Yarmoluk & Michail A. Tukalo
Pages: 201-207
Published online: 31 May 2016
AbstractforIdentification of Mycobacterium tuberculosis leucyl-tRNA synthetase (LeuRS) inhibitors among the derivatives of 5-phenylamino-2H-[1,2,4]triazin-3-one | Full Text | References | PDF (2.4 MB)
  • 1858 Views
  • 17 CrossRef citations
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Rapid Communication
Synthesis of two phloroglucinol derivatives with cinnamyl moieties as inhibitors of the carbonic anhydrase isozymes I and II: an in vitro study
Serdar Burmaoğlu, Esra Dilek, Ali Osman Yılmaz & Claudiu T. Supuran
Pages: 208-212
Published online: 13 May 2016
AbstractforSynthesis of two phloroglucinol derivatives with cinnamyl moieties as inhibitors of the carbonic anhydrase isozymes I and II: an in vitro study | Full Text | References | PDF (360.6 KB) | Supplemental
  • 1086 Views
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