31,913
Views
94
CrossRef citations to date
0
Altmetric
Report

Predicting Antibody Developability Profiles Through Early Stage Discovery Screening

, , , , , , , , , , , , , , , , , , , , & show all
Article: 1743053 | Received 19 Nov 2019, Accepted 04 Mar 2020, Published online: 05 Apr 2020

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (27)

Marissa Mock, Alex W. Jacobitz, Christopher James Langmead, Athena Sudom, Daniel Yoo, Sara C. Humphreys, Mai Alday, Larysa Alekseychyk, Nicolas Angell, Vivian Bi, Hannah Catterall, Chen-Chun Chen, Hui-Ting Chou, Kip P. Conner, Kevin D. Cook, Ana R. Correia, Andrew Dykstra, Sudipa Ghimire-Rijal, Kevin Graham, Peter Grandsard, Joon Huh, John O. Hui, Mani Jain, Victoria Jann, Lei Jia, Sheree Johnstone, Neelam Khanal, Carl Kolvenbach, Linda Narhi, Rupa Padaki, Emma M. Pelegri-O’Day, Wei Qi, Vladimir Razinkov, Austin J. Rice, Richard Smith, Christopher Spahr, Jennitte Stevens, Yax Sun, Veena A. Thomas, Sarah van Driesche, Robert Vernon, Victoria Wagner, Kenneth W. Walker, Yangjie Wei, Dwight Winters, Melissa Yang & Iain D. G. Campuzano. (2023) Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies. mAbs 15:1.
Read now
Andrew B. Waight, David Prihoda, Rojan Shrestha, Kevin Metcalf, Marc Bailly, Marco Ancona, Talal Widatalla, Zachary Rollins, Alan C Cheng, Danny A. Bitton & Laurence Fayadat-Dilman. (2023) A machine learning strategy for the identification of key in silico descriptors and prediction models for IgG monoclonal antibody developability properties. mAbs 15:1.
Read now
Chunting Zhang, Steven T. Gossert, Jonathan Williams, Michael Little, Marilia Barros, Barton Dear, Bradley Falk, Ankit D. Kanthe, Robert Garmise, Luciano Mueller, Andrew Ilott & Anuji Abraham. (2023) Ranking mAb–excipient interactions in biologics formulations by NMR spectroscopy and computational approaches. mAbs 15:1.
Read now
Lauren E. Boucher, Elisabeth Geyer Prinslow, Michael Feldkamp, Fang Yi, Rupesh Nanjunda, Sheng-Jiun Wu, Tun Liu, Eilyn R. Lacy, Steven Jacobs, Natalia Kozlyuk, Brian Del Rosario, Bingyuan Wu, Patricia Aquino, Robert C. Davidson, Samantha Heyne, Nicholas Mazzanti, James Testa, Michael D. Diem, Elsa Gorre, Andrew Mahan, Hirsh Nanda, Harsha P. Gunawardena, Alexis Gervais, Anthony A. Armstrong, Alexey Teplyakov, Chichi Huang, Adam Zwolak, Partha Chowdhury, Wan Cheung Cheung & Jinquan Luo. (2023) “Stapling” scFv for multispecific biotherapeutics of superior properties. mAbs 15:1.
Read now
Carl Mieczkowski, Xuejin Zhang, Dana Lee, Khanh Nguyen, Wei Lv, Yanling Wang, Yue Zhang, Jackie Way & Jean-Michel Gries. (2023) Blueprint for antibody biologics developability. mAbs 15:1.
Read now
Monica L. Fernández-Quintero, Anne Ljungars, Franz Waibl, Victor Greiff, Jan Terje Andersen, Torleif T. Gjølberg, Timothy P. Jenkins, Bjørn Gunnar Voldborg, Lise Marie Grav, Sandeep Kumar, Guy Georges, Hubert Kettenberger, Klaus R. Liedl, Peter M. Tessier, John McCafferty & Andreas H. Laustsen. (2023) Assessing developability early in the discovery process for novel biologics. mAbs 15:1.
Read now
Hristo L. Svilenov, Paolo Arosio, Tim Menzen, Peter Tessier & Pietro Sormanni. (2023) Approaches to expand the conventional toolbox for discovery and selection of antibodies with drug-like physicochemical properties. mAbs 15:1.
Read now
Andrew Dippel, Austin Gallegos, Vineela Aleti, Arnita Barnes, Xiaoru Chen, Elizabeth Christian, Jared Delmar, Qun Du, Reza Esfandiary, Erika Farmer, Andrew Garcia, Qing Li, Jia Lin, Weiyi Liu, LeeAnn Machiesky, Neil Mody, Arun Parupudi, Meagan Prophet, Keith Rickert, Kim Rosenthal, Song Ren, Harini Shandilya, Reena Varkey, Kevin Wons, Yuling Wu, Yueh-Ming Loo, Mark T. Esser, Nicole L. Kallewaard, Sarav Rajan, Melissa Damschroder, Weichen Xu & Gilad Kaplan. (2023) Developability profiling of a panel of Fc engineered SARS-CoV-2 neutralizing antibodies. mAbs 15:1.
Read now
James T. Heads, Sebastian Kelm, Kerry Tyson & Alastair D. G. Lawson. (2022) A computational method for predicting the aggregation propensity of IgG1 and IgG4(P) mAbs in common storage buffers. mAbs 14:1.
Read now
Hitomi Masuda, Atsushi Sawada, Shu-ichi Hashimoto, Kanako Tamai, Ke-Yi Lin, Naoto Harigai, Kohei Kurosawa, Kunihiro Ohta, Hidetaka Seo & Hiroshi Itou. (2022) Fast-tracking antibody maturation using a B cell-based display system. mAbs 14:1.
Read now
Line Ledsgaard, Andreas H. Laustsen, Urska Pus, Jack Wade, Pedro Villar, Kim Boddum, Peter Slavny, Edward W. Masters, Ana S. Arias, Saioa Oscoz, Daniel T. Griffiths, Alice M. Luther, Majken Lindholm, Rachael A. Leah, Marie Sofie Møller, Hanif Ali, John McCafferty, Bruno Lomonte, José M. Gutiérrez & Aneesh Karatt-Vellatt. (2022) In vitro discovery of a human monoclonal antibody that neutralizes lethality of cobra snake venom. mAbs 14:1.
Read now
Yanyun Liu, Kenny Tsang, Michelle Mays, Gale Hansen, Jeffrey Chiecko, Maureen Crames, Yangjie Wei, Weijie Zhou, Chase Fredrick, James Hu, Dongmei Liu, Douglas Gebhard, Zhong-Fu Huang, Akshita Datar, Anthony Kronkaitis, Kristina Gueneva-Boucheva, Daniel Seeliger, Fei Han, Saurabh Sen, Srinath Kasturirangan, Justin M. Scheer, Andrew E. Nixon, Tadas Panavas, Michael S. Marlow & Sandeep Kumar. (2022) An adapted consensus protein design strategy for identifying globally optimal biotherapeutics. mAbs 14:1.
Read now
Rahmad Akbar, Philippe A. Robert, Cédric R. Weber, Michael Widrich, Robert Frank, Milena Pavlović, Lonneke Scheffer, Maria Chernigovskaya, Igor Snapkov, Andrei Slabodkin, Brij Bhushan Mehta, Enkelejda Miho, Fridtjof Lund-Johansen, Jan Terje Andersen, Sepp Hochreiter, Ingrid Hobæk Haff, Günter Klambauer, Geir Kjetil Sandve & Victor Greiff. (2022) In silico proof of principle of machine learning-based antibody design at unconstrained scale. mAbs 14:1.
Read now
David Prihoda, Jad Maamary, Andrew Waight, Veronica Juan, Laurence Fayadat-Dilman, Daniel Svozil & Danny A. Bitton. (2022) BioPhi: A platform for antibody design, humanization, and humanness evaluation based on natural antibody repertoires and deep learning. mAbs 14:1.
Read now
Rahul Khetan, Robin Curtis, Charlotte M. Deane, Johannes Thorling Hadsund, Uddipan Kar, Konrad Krawczyk, Daisuke Kuroda, Sarah A. Robinson, Pietro Sormanni, Kouhei Tsumoto, Jim Warwicker & Andrew C.R. Martin. (2022) Current advances in biopharmaceutical informatics: guidelines, impact and challenges in the computational developability assessment of antibody therapeutics. mAbs 14:1.
Read now
Rahmad Akbar, Habib Bashour, Puneet Rawat, Philippe A. Robert, Eva Smorodina, Tudor-Stefan Cotet, Karine Flem-Karlsen, Robert Frank, Brij Bhushan Mehta, Mai Ha Vu, Talip Zengin, Jose Gutierrez-Marcos, Fridtjof Lund-Johansen, Jan Terje Andersen & Victor Greiff. (2022) Progress and challenges for the machine learning-based design of fit-for-purpose monoclonal antibodies. mAbs 14:1.
Read now
Dustin Hicks, Carly Baehr, Pedro Silva-Ortiz, Aaron Khaimraj, Diego Luengas, Fatima A. Hamid & Marco Pravetoni. (2022) Advancing humanized monoclonal antibody for counteracting fentanyl toxicity towards clinical development. Human Vaccines & Immunotherapeutics 18:6.
Read now
Nileena Velappan, Hau B. Nguyen, Sofiya Micheva-Viteva, Daniel Bedinger, Chunyan Ye, Betty Mangadu, Austin J. Watts, Robert Meagher, Steven Bradfute, Bin Hu, Geoffrey S. Waldo & Antonietta M. Lillo. (2022) Healthy humans can be a source of antibodies countering COVID-19. Bioengineered 13:5, pages 12598-12624.
Read now
Shufang Liu, Ashwni Verma, Hubert Kettenberger, Wolfgang F. Richter & Dhaval K. Shah. (2021) Effect of variable domain charge on in vitro and in vivo disposition of monoclonal antibodies. mAbs 13:1.
Read now
Andre Azevedo Reis Teixeira, Michael Frank Erasmus, Sara D’Angelo, Leslie Naranjo, Fortunato Ferrara, Camila Leal-Lopes, Oliver Durrant, Cecile Galmiche, Aleardo Morelli, Anthony Scott-Tucker & Andrew Raymon Morton Bradbury. (2021) Drug-like antibodies with high affinity, diversity and developability directly from next-generation antibody libraries. mAbs 13:1.
Read now
Norbert Furtmann, Marion Schneider, Nadja Spindler, Bjoern Steinmann, Ziyu Li, Ingo Focken, Joachim Meyer, Dilyana Dimova, Katja Kroll, Wulf Dirk Leuschner, Audrey Debeaumont, Magali Mathieu, Christian Lange, Werner Dittrich, Jochen Kruip, Thorsten Schmidt & Joerg Birkenfeld. (2021) An end-to-end automated platform process for high-throughput engineering of next-generation multi-specific antibody therapeutics. mAbs 13:1.
Read now
Emily K. Makowski, Lina Wu, Alec A. Desai & Peter M. Tessier. (2021) Highly sensitive detection of antibody nonspecific interactions using flow cytometry. mAbs 13:1.
Read now

Articles from other publishers (67)

Daniel Keri, Matt Walker, Isha Singh, Kyle Nishikawa & Fernando Garces. (2023) Next generation of multispecific antibody engineering. Antibody Therapeutics.
Crossref
Yangjie Wei, Wei Qi, Erick Maglalang, Emma M. Pelegri-O’Day, Michelle Luong, Vladimir Razinkov & Christopher Sloey. (2023) Improved Diffusion Interaction Parameter Measurement to Predict the Viscosity of Concentrated mAb Solutions. Molecular Pharmaceutics 20:12, pages 6420-6428.
Crossref
Kamal Bhandari, Yangjie Wei, Brendan R. Amer, Emma M. Pelegri-O’Day, Joon Huh & Jeremy D. Schmit. (2023) Prediction of Antibody Viscosity from Dilute Solution Measurements. Antibodies 12:4, pages 78.
Crossref
Pankaj Gupta, Alexander M. Horspool, Goral Trivedi, Gina Moretti, Akshita Datar, Zhong-Fu Huang, Jeffrey Chiecko, Cynthia Hess Kenny & Michael S. Marlow. (2023) Matrixed CDR-grafting: a neoclassical framework for antibody humanization and developability. Journal of Biological Chemistry, pages 105555.
Crossref
Krishnan Sampathkumar & Bruce A. Kerwin. (2023) Roadmap for Drug Product Development and Manufacturing of Biologics. Journal of Pharmaceutical Sciences.
Crossref
Rudger Hess, Jan Faessler, Doil Yun, David Saleh, Jan-Hendrik Grosch, Thomas Schwab & Jürgen Hubbuch. (2023) Antibody sequence-based prediction of pH gradient elution in multimodal chromatography. Journal of Chromatography A 1711, pages 464437.
Crossref
Yuwei Zhou, Ziru Huang, Wenzhen Li, Jinyi Wei, Qianhu Jiang, Wei Yang & Jian Huang. (2023) Deep learning in preclinical antibody drug discovery and development. Methods 218, pages 57-71.
Crossref
Leon F. Willis, Vishal Toprani, Sashini Wijetunge, Annette Sievers, Laura Lin, Jeanine Williams, Tom J. Crowley, Sheena E. Radford, Nikil Kapur & David J. Brockwell. (2023) Exploring a role for flow-induced aggregation assays in platform formulation optimisation for antibody-based proteins. Journal of Pharmaceutical Sciences.
Crossref
Alexander W. Golinski, Zachary D. Schmitz, Gregory H. Nielsen, Bryce Johnson, Diya Saha, Sandhya Appiah, Benjamin J. Hackel & Stefano Martiniani. (2023) Predicting and Interpreting Protein Developability Via Transfer of Convolutional Sequence Representation. ACS Synthetic Biology 12:9, pages 2600-2615.
Crossref
Adrian D. Hobson, Jianwen Xu, Dennie S. Welch, Christopher C. Marvin, Michael J. McPherson, Bradley Gates, Xiaoli Liao, Markus Hollmann, Michael J. Gattner, Kristina Dzeyk, Hetal Sarvaiya, Vikram M. Shenoy, Margaret M. Fettis, Agnieszka K. Bischoff, Lu Wang, Ling C. Santora, Lu Wang, Julia Fitzgibbons, Paulin Salomon, Axel HernandezJr.Jr., Ying Jia, Christian A. Goess, Suzanne L. Mathieu, Shaughn H. Bryant, Mary E. Larsen, Baoliang Cui & Yu Tian. (2023) Discovery of ABBV-154, an anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC). Journal of Medicinal Chemistry 66:17, pages 12544-12558.
Crossref
Gabriele Recanati, Magdalena Pappenreiter, Christoph Gstoettner, Patrick Scheidl, Elena Domínguez Vega, Bernhard Sissolak & Alois Jungbauer. (2023) Integration of a perfusion reactor and continuous precipitation in an entirely membrane‐based process for antibody capture. Engineering in Life Sciences.
Crossref
Emily K. Makowski, Tiexin Wang, Jennifer M. Zupancic, Jie Huang, Lina Wu, John S. Schardt, Anne S. De Groot, Stephanie L. Elkins, William D. Martin & Peter M. Tessier. (2023) Optimization of therapeutic antibodies for reduced self-association and non-specific binding via interpretable machine learning. Nature Biomedical Engineering.
Crossref
Iain D. G. Campuzano. (2023) A Research Journey: Over a Decade of Denaturing and Native-MS Analyses of Hydrophobic and Membrane Proteins in Amgen Therapeutic Discovery. Journal of the American Society for Mass Spectrometry.
Crossref
Joschka Bauer, Nandhini Rajagopal, Priyanka Gupta, Pankaj Gupta, Andrew E. Nixon & Sandeep Kumar. (2023) How can we discover developable antibody-based biotherapeutics?. Frontiers in Molecular Biosciences 10.
Crossref
Kovilen Sawmynaden, Nicholas Wong, Sarah Davies, Richard Cowan, Richard Brown, David Tang, Maud Henry, David Tickle, David Matthews, Mark Carr, Preeti Bakrania, Hong Hoi Ting & Gareth Hall. (2023) Co-crystallisation and humanisation of an anti-HER2 single-domain antibody as a theranostic tool. PLOS ONE 18:7, pages e0288259.
Crossref
Adrian D. Hobson, Jianwen Xu, Christopher C. Marvin, Michael J. McPherson, Markus Hollmann, Michael Gattner, Kristina Dzeyk, Margaret M. Fettis, Agnieszka K. Bischoff, Lu Wang, Julia Fitzgibbons, Lu Wang, Paulin Salomon, Axel HernandezJr.Jr., Ying Jia, Hetal Sarvaiya, Christian A. Goess, Suzanne L. Mathieu & Ling C. Santora. (2023) Optimization of Drug-Linker to Enable Long-term Storage of Antibody–Drug Conjugate for Subcutaneous Dosing. Journal of Medicinal Chemistry 66:13, pages 9161-9173.
Crossref
Brittney J. Mills, Malika P. Godamudunage, Siyuan Ren & Malabika Laha. (2023) Predictive Nature of High-Throughput Assays in ADC Formulation Screening. Journal of Pharmaceutical Sciences 112:7, pages 1821-1831.
Crossref
Yingjie Zhang, Qing Li, Liang Luo, Changfei Duan, Jianzhong Shen & Zhanhui Wang. (2023) Application of germline antibody features to vaccine development, antibody discovery, antibody optimization and disease diagnosis. Biotechnology Advances 65, pages 108143.
Crossref
Amjad A. Chowdhury, Neha Manohar, Marta A. Witek, Mahlet A. Woldeyes, Ranajoy Majumdar, Ken K. Qian, William D. Kimball, Shifeng Xu, Alfredo Lanzaro, Thomas M. Truskett & Keith P. Johnston. (2023) Subclass Effects on Self-Association and Viscosity of Monoclonal Antibodies at High Concentrations. Molecular Pharmaceutics 20:6, pages 2991-3008.
Crossref
David Roush, Michael Iammarino, Rebecca Chmielowski, Francis Insaidoo, Mark A. McCoy, Allison Ortigosa & Michael Rauscher. (2023) Insulin purification—Innovation continuum via synthesis of fundamentals, technology, and modeling. Biotechnology and Bioengineering.
Crossref
Nadia A. Erkamp, Marc Oeller, Tomas SneiderisHannes AusserwogerAviad Levin, Timothy J. Welsh, Runzhang QiDaoyuan Qian, Nikolai Lorenzen, Hongjia ZhuPietro SormanniMichele Vendruscolo & Tuomas P.J. Knowles. (2023) Multidimensional Protein Solubility Optimization with an Ultrahigh-Throughput Microfluidic Platform. Analytical Chemistry 95:12, pages 5362-5368.
Crossref
Jisun Kim, Matthew McFee, Qiao Fang, Osama Abdin & Philip M. Kim. (2023) Computational and artificial intelligence-based methods for antibody development. Trends in Pharmacological Sciences 44:3, pages 175-189.
Crossref
Matthew F. Higgins, Nicholas Abu‐Absi, Elena Gontarz, Ingo H. Gorr, Klaus Kaiser, Pramthesh Patel, Frank Ritacco, Patrick Sheehy, Balakumar Thangaraj & Tony Gill. (2023) Accelerated CMC workflows to enable speed to clinic in the COVID ‐19 era: A multi‐company view from the biopharmaceutical industry . Biotechnology Progress 39:2.
Crossref
Giuseppe Licari, Kyle P. Martin, Maureen Crames, Joseph Mozdzierz, Michael S. Marlow, Anne R. Karow-Zwick, Sandeep Kumar & Joschka Bauer. (2022) Embedding Dynamics in Intrinsic Physicochemical Profiles of Market-Stage Antibody-Based Biotherapeutics. Molecular Pharmaceutics 20:2, pages 1096-1111.
Crossref
Joachim Schuster, Vinay Kamuju & Roman Mathaes. (2023) Protein Stability After Administration: A Physiologic Consideration. Journal of Pharmaceutical Sciences 112:2, pages 370-376.
Crossref
Markos Trikeriotis, Sergey Akbulatov, Umberto Esposito, Athanasios Anastasiou & Oksana I. Leszczyszyn. (2022) Analytical Workflows to Unlock Predictive Power in Biotherapeutic Developability. Pharmaceutical Research 40:2, pages 487-500.
Crossref
Weijie Zhang, Hao Wang, Nan Feng, Yifeng Li, Jijie Gu & Zhuozhi Wang. (2023) Developability assessment at early-stage discovery to enable development of antibody-derived therapeutics. Antibody Therapeutics 6:1, pages 13-29.
Crossref
Zhidong Chen, Xinpei Wang, Xu Chen, Juyang Huang, Chenglin Wang, Junqing Wang & Zhe Wang. (2023) Accelerating therapeutic protein design with computational approaches toward the clinical stage. Computational and Structural Biotechnology Journal 21, pages 2909-2926.
Crossref
Susan Miller, Walter Moos, Barbara Munk, Stephen Munk, Charles Hart & David Spellmeyer. 2023. Managing the Drug Discovery Process. Managing the Drug Discovery Process 339 415 .
Andreas Evers, Shipra Malhotra, Wolf-Guido Bolick, Ahmad Najafian, Maria Borisovska, Shira Warszawski, Yves Fomekong Nanfack, Daniel Kuhn, Friedrich Rippmann, Alejandro Crespo & Vanita Sood. 2023. Genotype Phenotype Coupling. Genotype Phenotype Coupling 383 398 .
Nels Thorsteinson, Stephen R. ComeauJrJr & Sandeep Kumar. 2023. Computer-Aided Antibody Design. Computer-Aided Antibody Design 219 235 .
Xin Yu Koh, Xiao Hui Koh, Diana Spiegelberg, Preeti Jha, Marika Nestor, Le-ann Hwang, Ban Xiong Tan & David Philip Lane. (2022) Conformation specific antagonistic high affinity antibodies to the RON receptor kinase for imaging and therapy. Scientific Reports 12:1.
Crossref
Alain Beck, Christine Nowak, Deborah Meshulam, Kristina Reynolds, David Chen, Dennis B. Pacardo, Samantha B. Nicholls, Gregory J. Carven, Zhenyu Gu, Jing Fang, Dongdong Wang, Amit Katiyar, Tao Xiang & Hongcheng Liu. (2022) Risk-Based Control Strategies of Recombinant Monoclonal Antibody Charge Variants. Antibodies 11:4, pages 73.
Crossref
Hannes Ausserwöger, Matthias M. Schneider, Therese W. Herling, Paolo Arosio, Gaetano Invernizzi, Tuomas P. J. Knowles & Nikolai Lorenzen. (2022) Non-specificity as the sticky problem in therapeutic antibody development. Nature Reviews Chemistry 6:12, pages 844-861.
Crossref
Iain D. G. Campuzano, Emma M. Pelegri-O’Day, Nithya Srinivasan, Jennifer L. Lippens, Pascal Egea, Aiko Umeda, Jennifer Aral, Tianqi Zhang, Arthur Laganowsky & Chawita Netirojjanakul. (2022) High-Throughput Mass Spectrometry for Biopharma: A Universal Modality and Target Independent Analytical Method for Accurate Biomolecule Characterization. Journal of the American Society for Mass Spectrometry 33:11, pages 2191-2198.
Crossref
Soo Hyun Kim, Han Ju Yoo, Eun Ji Park, Wonhwa Lee & Dong Hee Na. (2022) Impact of buffer concentration on the thermal stability of immunoglobulin G. Journal of Pharmaceutical Investigation 52:6, pages 739-747.
Crossref
Jiangyan Feng, Min Jiang, James Shih & Qing Chai. (2022) Antibody apparent solubility prediction from sequence by transfer learning. iScience 25:10, pages 105173.
Crossref
Kannan Sankar, Kyle Trainor, Levi L. Blazer, Jarrett J. Adams, Sachdev S. Sidhu, Tyler Day, Elizabeth Meiering & Johannes K. X. Maier. (2022) A Descriptor Set for Quantitative Structure‐property Relationship Prediction in Biologics. Molecular Informatics 41:9.
Crossref
Emily K. Makowski, Patrick C. Kinnunen, Jie Huang, Lina Wu, Matthew D. Smith, Tiexin Wang, Alec A. Desai, Craig N. Streu, Yulei Zhang, Jennifer M. Zupancic, John S. Schardt, Jennifer J. Linderman & Peter M. Tessier. (2022) Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space. Nature Communications 13:1.
Crossref
Deenesh K Babi, Jan Griesbach, Stephen Hunt, Francis Insaidoo, David Roush, Robert Todd, Arne Staby, John Welsh & Felix Wittkopp. (2022) Opportunities and challenges for model utilization in the biopharmaceutical industry: current versus future state. Current Opinion in Chemical Engineering 36, pages 100813.
Crossref
Kalyan Pande, Scott A. Hollingsworth, Miranda Sam, Qinshan Gao, Sujata Singh, Anasuya Saha, Karin Vroom, Xiaohong Shirley Ma, Tres Brazell, Dan Gorman, Shi-Juan Chen, Fahimeh Raoufi, Marc Bailly, David Grandy, Karthik Sathiyamoorthy, Lan Zhang, Rob Thompson, Alan C. Cheng, Laurence Fayadat-Dilman, Bernhard H. Geierstanger & Laura J. Kingsley. (2022) Hexamerization of Anti-SARS CoV IgG1 Antibodies Improves Neutralization Capacity. Frontiers in Immunology 13.
Crossref
Karen E. Butler, James N. Dodds, Tawnya Flick, Iain D. G. Campuzano & Erin S. Baker. (2022) High-Resolution Demultiplexing (HRdm) Ion Mobility Spectrometry–Mass Spectrometry for Aspartic and Isoaspartic Acid Determination and Screening. Analytical Chemistry 94:16, pages 6191-6199.
Crossref
Tapan K. Das, Danny K. Chou, Wim Jiskoot & Paolo Arosio. (2022) Nucleation in Protein Aggregation in Biotherapeutic Development: A look into the Heart of the Event. Journal of Pharmaceutical Sciences 111:4, pages 951-959.
Crossref
Soo Ghee Yeoh, Jia Siang Sum, Jing Yi Lai, W Y Haniff W Isa & Theam Soon Lim. (2021) Potential of Phage Display Antibody Technology for Cardiovascular Disease Immunotherapy. Journal of Cardiovascular Translational Research 15:2, pages 360-380.
Crossref
Andreas Evers, Didier Clénet & Stefania Pfeiffer-Marek. (2022) Long-Term Stability Prediction for Developability Assessment of Biopharmaceutics Using Advanced Kinetic Modeling. Pharmaceutics 14:2, pages 375.
Crossref
John S. Schardt, Harkamal S. Jhajj, Ryen L. O'Meara, Timon S. Lwo, Matthew D. Smith & Peter M. Tessier. (2022) Agonist antibody discovery: Experimental, computational, and rational engineering approaches. Drug Discovery Today 27:1, pages 31-48.
Crossref
Andreas H. Laustsen, Victor Greiff, Aneesh Karatt-Vellatt, Serge Muyldermans & Timothy P. Jenkins. (2021) Animal Immunization, in Vitro Display Technologies, and Machine Learning for Antibody Discovery. Trends in Biotechnology 39:12, pages 1263-1273.
Crossref
James Austerberry, John Edwards, Tim Eyes & Jeremy P. Derrick. (2021) Use of Peptide Microarrays for Fast and Informative Profiling of Therapeutic Antibody Formulation Conditions. Molecular Pharmaceutics 18:11, pages 4131-4139.
Crossref
Bertie Chi, Geoffrey De Oliveira, Tom Gallagher, Laura Mitchell, Louise Knightley, Cynthia C. Gonzalez, Shannon Russell, Volker Germaschewski, Claire Pearce & Christopher A. Sellick. (2021) Pragmatic mAb lead molecule engineering from a developability perspective. Biotechnology and Bioengineering 118:10, pages 3733-3743.
Crossref
Jonathan S. Kingsbury, Michaela M. Lantz, Amandeep Saini, Michael Z. Wang & Yatin R. Gokarn. (2021) Characterization of Opalescence in low Volume Monoclonal Antibody Solutions Enabled by Microscale Nephelometry. Journal of Pharmaceutical Sciences 110:9, pages 3176-3182.
Crossref
Iain D. G. Campuzano & Wendy Sandoval. (2021) Denaturing and Native Mass Spectrometric Analytics for Biotherapeutic Drug Discovery Research: Historical, Current, and Future Personal Perspectives. Journal of the American Society for Mass Spectrometry 32:8, pages 1861-1885.
Crossref
David Saleh, Rudger Hess, Michelle Ahlers‐Hesse, Nicole Beckert, Markus Schönberger, Federico Rischawy, Gang Wang, Joschka Bauer, Michaela Blech, Simon Kluters, Joey Studts & Jürgen Hubbuch. (2021) Modeling the impact of amino acid substitution in a monoclonal antibody on cation exchange chromatography. Biotechnology and Bioengineering 118:8, pages 2923-2933.
Crossref
Yash Kapoor, Robert F. Meyer, Heidi M. Ferguson, Daniel Skomski, Pierre Daublain, Gregory M. Troup, Chad Dalton, Manoharan Ramasamy & Allen C. Templeton. (2021) Flexibility in Drug Product Development: A Perspective. Molecular Pharmaceutics 18:7, pages 2455-2469.
Crossref
Catherine Forest-Nault, Jimmy Gaudreault, Olivier Henry, Yves Durocher & Gregory De Crescenzo. (2021) On the Use of Surface Plasmon Resonance Biosensing to Understand IgG-FcγR Interactions. International Journal of Molecular Sciences 22:12, pages 6616.
Crossref
Alexander W. Golinski, Katelynn M. Mischler, Sidharth Laxminarayan, Nicole L. Neurock, Matthew Fossing, Hannah Pichman, Stefano Martiniani & Benjamin J. Hackel. (2021) High-throughput developability assays enable library-scale identification of producible protein scaffold variants. Proceedings of the National Academy of Sciences 118:23.
Crossref
Carolin Berner, Tim Menzen, Gerhard Winter & Hristo L. Svilenov. (2021) Combining Unfolding Reversibility Studies and Molecular Dynamics Simulations to Select Aggregation-Resistant Antibodies. Molecular Pharmaceutics 18:6, pages 2242-2253.
Crossref
Yi Wen & Vibha Jawa. (2021) The Impact of Product and Process Related Critical Quality Attributes on Immunogenicity and Adverse Immunological Effects of Biotherapeutics. Journal of Pharmaceutical Sciences 110:3, pages 1025-1041.
Crossref
Harini Narayanan, Fabian Dingfelder, Alessandro Butté, Nikolai Lorenzen, Michael Sokolov & Paolo Arosio. (2021) Machine Learning for Biologics: Opportunities for Protein Engineering, Developability, and Formulation. Trends in Pharmacological Sciences 42:3, pages 151-165.
Crossref
Carl Mieczkowski, Alan Cheng, Thierry Fischmann, Mark Hsieh, Jeanne Baker, Makiko Uchida, Gopalan Raghunathan, Corey Strickland & Laurence Fayadat-Dilman. (2021) Characterization and Modeling of Reversible Antibody Self-Association Provide Insights into Behavior, Prediction, and Correction. Antibodies 10:1, pages 8.
Crossref
Lowell J. Brady. 2021. Monoclonal Antibodies. Monoclonal Antibodies 121 159 .
Victor Greiff, Gur Yaari & Lindsay G. Cowell. (2020) Mining adaptive immune receptor repertoires for biological and clinical information using machine learning. Current Opinion in Systems Biology 24, pages 109-119.
Crossref
Carl Mieczkowski, Soheila Bahmanjah, Yao Yu, Jeanne Baker, Gopalan Raghunathan, Daniela Tomazela, Mark Hsieh, Mark McCoy, Corey Strickland & Laurence Fayadat-Dilman. (2020) Crystal Structure and Characterization of Human Heavy-Chain Only Antibodies Reveals a Novel, Stable Dimeric Structure Similar to Monoclonal Antibodies. Antibodies 9:4, pages 66.
Crossref
John Crissman, Yuhao Lin, Kevin Separa, Madeleine Duquette, Michael Cohen, Candyd Velasquez & Thomas Cujec. (2020) RNase H-dependent PCR enables highly specific amplification of antibody variable domains from single B-cells. PLOS ONE 15:11, pages e0241803.
Crossref
Micael Karlberg, João Victor de Souza, Lanyu Fan, Arathi Kizhedath, Agnieszka K. Bronowska & Jarka Glassey. (2020) QSAR Implementation for HIC Retention Time Prediction of mAbs Using Fab Structure: A Comparison between Structural Representations. International Journal of Molecular Sciences 21:21, pages 8037.
Crossref
Yang Li, Baofu Qiao & Monica Olvera de la Cruz. (2020) Protein Surface Printer for Exploring Protein Domains. Journal of Chemical Information and Modeling 60:10, pages 5255-5264.
Crossref
Manali S. Sawant, Craig N. Streu, Lina Wu & Peter M. Tessier. (2020) Toward Drug-Like Multispecific Antibodies by Design. International Journal of Molecular Sciences 21:20, pages 7496.
Crossref
Dhanuka P. Wasalathanthri, Matthew S. Rehmann, Yuanli Song, Yan Gu, Luo Mi, Chun Shao, Letha Chemmalil, Jongchan Lee, Sanchayita Ghose, Michael C. Borys, Julia Ding & Zheng Jian Li. (2020) Technology outlook for real‐time quality attribute and process parameter monitoring in biopharmaceutical development—A review. Biotechnology and Bioengineering 117:10, pages 3182-3198.
Crossref