Cancer Biology & Therapy, Volume 15, Issue 8 (2014)

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Cancer Biology & Therapy, Volume 15, Issue 8 (2014)

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Letter to the Editor

Letter
Pancreatic Cancer Database
An integrative resource for pancreatic cancer
Joji Kurian Thomas, Min-Sik Kim, Lavanya Balakrishnan, Vishalakshi Nanjappa, Rajesh Raju, Arivusudar Marimuthu, Aneesha Radhakrishnan, Babylakshmi Muthusamy, Aafaque Ahmad Khan, Sruthi Sakamuri, Shantal Gupta Tankala, Mukul Singal, Bipin Nair, Ravi Sirdeshmukh, Aditi Chatterjee, T S Keshava Prasad, Anirban Maitra, Harsha Gowda, Ralph H Hruban & Akhilesh Pandey
Pages: 963-967
Published online: 19 May 2014
AbstractforPancreatic Cancer Database | Full Text | References | PDF (1.4 MB)
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Journal Club

Article Commentary
New mechanism of lenalidomide activity
Jacob Keevan & William D Figg
Pages: 968-969
Published online: 19 May 2014
AbstractforNew mechanism of lenalidomide activity | Full Text | References | PDF (626.9 KB)
  • 841 Views
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Bedside to Bench Report

Article
Successful treatment of a patient with Li–Fraumeni syndrome and metastatic lung adenocarcinoma harboring synchronous EGFR L858R and ERBB2 extracellular domain S310F mutations with the pan-HER inhibitor afatinib
Yuxia Jia, Siraj M Ali, Shumaila Saad, Courtney A Chan, Vincent A Miller & Balazs Halmos
Pages: 970-974
Published online: 16 May 2014
AbstractforSuccessful treatment of a patient with Li–Fraumeni syndrome and metastatic lung adenocarcinoma harboring synchronous EGFR L858R and ERBB2 extracellular domain S310F mutations with the pan-HER inhibitor afatinib | Full Text | References | PDF (1.2 MB)
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Clinical Study

Article
Dual VEGF/VEGFR inhibition in advanced solid malignancies
Clinical effects and pharmacodynamic biomarkers
Kriti Mittal, Henry Koon, Paul Elson, Pierre Triozzi, Afshin Dowlati, Helen Chen, Ernest C Borden & Brian I Rini
Pages: 975-981
Published online: 19 May 2014
AbstractforDual VEGF/VEGFR inhibition in advanced solid malignancies | Full Text | References | PDF (900.4 KB)
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Research Paper

Article
Activation of p38-MAPK by CXCL4/CXCR3 axis contributes to p53-dependent intestinal apoptosis initiated by 5-fluorouracil
Jing Gao, Jin Gao, Lan Qian, Xia Wang, Mingyuan Wu, Yang Zhang, Hao Ye, Shunying Zhu, Yan Yu & Wei Han
Pages: 982-991
Published online: 06 May 2014
AbstractforActivation of p38-MAPK by CXCL4/CXCR3 axis contributes to p53-dependent intestinal apoptosis initiated by 5-fluorouracil | Full Text | References | PDF (2.2 MB) | Supplemental
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Article
Rapamycin enhances cetuximab cytotoxicity by inhibiting mTOR-mediated drug resistance in mesenchymal hepatoma cells
Wei Chen, Qi-Da Hu, Xue-Feng Xia, Chao Liang, Hao Liu, Qi Zhang, Tao Ma, Feng Liang & Ting-Bo Liang
Pages: 992-999
Published online: 06 May 2014
AbstractforRapamycin enhances cetuximab cytotoxicity by inhibiting mTOR-mediated drug resistance in mesenchymal hepatoma cells | Full Text | References | PDF (2.1 MB) | Supplemental
  • 1362 Views
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Article
Doxorubicin and 5-fluorouracil induced accumulation and transcriptional activity of p53 are independent of the phosphorylation at serine 15 in MCF-7 breast cancer cells
Matthew T Balmer, Ryan D Katz, Si Liao, James S Goodwine & Susannah Gal
Pages: 1000-1012
Published online: 06 May 2014
AbstractforDoxorubicin and 5-fluorouracil induced accumulation and transcriptional activity of p53 are independent of the phosphorylation at serine 15 in MCF-7 breast cancer cells | Full Text | References | PDF (1.6 MB)
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Article
Adeno-associated virus type 2 infection of nude mouse human breast cancer xenograft induces necrotic death and inhibits tumor growth
Samina Alam, Brian S Bowser, Mohd Israr, Michael J Conway & Craig Meyers
Pages: 1013-1028
Published online: 16 May 2014
AbstractforAdeno-associated virus type 2 infection of nude mouse human breast cancer xenograft induces necrotic death and inhibits tumor growth | Full Text | References | PDF (2.6 MB) | Supplemental
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Article
Trastuzumab-induced recruitment of Csk-homologous kinase (CHK) to ErbB2 receptor is associated with ErbB2-Y1248 phosphorylation and ErbB2 degradation to mediate cell growth inhibition
Milos Dokmanovic, Yun Wu, Yi Shen, Jieqing Chen, Dianne S Hirsch & Wen Jin Wu
Pages: 1029-1041
Published online: 16 May 2014
AbstractforTrastuzumab-induced recruitment of Csk-homologous kinase (CHK) to ErbB2 receptor is associated with ErbB2-Y1248 phosphorylation and ErbB2 degradation to mediate cell growth inhibition | Full Text | References | PDF (6.7 MB) | Supplemental
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Article
Context-dependent function of the deubiquitinating enzyme USP9X in pancreatic ductal adenocarcinoma
Jesse L Cox, Phillip J Wilder, Erin L Wuebben, Michel M Ouellette, Michael A Hollingsworth & Angie Rizzino
Pages: 1042-1052
Published online: 19 May 2014
AbstractforContext-dependent function of the deubiquitinating enzyme USP9X in pancreatic ductal adenocarcinoma | Full Text | References | PDF (1.5 MB) | Supplemental
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Article
Combination therapy with anti-DR5 antibody and tamoxifen for triple negative breast cancer
Hyunki Kim, Sharon L Samuel, Guihua Zhai, Samir Rana, Marie Taylor, Heidi R Umphrey, Denise K Oelschlager, Donald J Buchsbaum & Kurt R Zinn
Pages: 1053-1060
Published online: 19 May 2014
AbstractforCombination therapy with anti-DR5 antibody and tamoxifen for triple negative breast cancer | Full Text | References | PDF (4 MB)
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Article
Clodronate inhibits tumor angiogenesis in mouse models of ovarian cancer
Nicole M Reusser, Heather J Dalton, Sunila Pradeep, Vianey Gonzalez-Villasana, Nicholas B Jennings, Hernan G Vasquez, Yunfei Wen, Rajesh Rupaimoole, Archana S Nagaraja, Kshipra Gharpure, Takahito Miyake, Jie Huang, Wei Hu, Gabriel Lopez-Berestein & Anil K Sood
Pages: 1061-1067
Published online: 19 May 2014
AbstractforClodronate inhibits tumor angiogenesis in mouse models of ovarian cancer | Full Text | References | PDF (3.1 MB)
  • 1400 Views
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Article
A Salmonella Typhimurium mutant strain capable of RNAi delivery
Higher tumor-targeting and lower toxicity
Xiawei Cheng, Xiaoxin Zhang, Yuqiang Zhou, Chunmei Zhang & Zi-Chun Hua
Pages: 1068-1076
Published online: 19 May 2014
AbstractforA Salmonella Typhimurium mutant strain capable of RNAi delivery | Full Text | References | PDF (1.8 MB)
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Article
Maritoclax induces apoptosis in acute myeloid leukemia cells with elevated Mcl-1 expression
Kenichiro Doi, Qiang Liu, Krishne Gowda, Brian M Barth, David Claxton, Shantu Amin, Thomas P Loughran Jr & Hong-Gang Wang
Pages: 1077-1086
Published online: 19 May 2014
AbstractforMaritoclax induces apoptosis in acute myeloid leukemia cells with elevated Mcl-1 expression | Full Text | References | PDF (1.6 MB) | Supplemental
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Article
Ran GTPase protein promotes metastasis and invasion in pancreatic cancer by deregulating the expression of AR and CXCR4
Lin Deng, Yulong Shang, Shikong Guo, Changhao Liu, Lin Zhou, Yi Sun, Yongzhan Nie, Daiming Fan, Yuanyuan Lu & Xuegang Guo
Pages: 1087-1093
Published online: 19 May 2014
AbstractforRan GTPase protein promotes metastasis and invasion in pancreatic cancer by deregulating the expression of AR and CXCR4 | Full Text | References | PDF (2.5 MB)
  • 985 Views
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Article
Zscan4 interacts directly with human Rap1 in cancer cells regardless of telomerase status
Kyungwoo Lee & Lauren S Gollahon
Pages: 1094-1105
Published online: 19 May 2014
AbstractforZscan4 interacts directly with human Rap1 in cancer cells regardless of telomerase status | Full Text | References | PDF (3 MB)
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Article
Generation and characterization of an analog-sensitive PERK allele
Nancy L Maas, Nickpreet Singh & J Alan Diehl
Pages: 1106-1111
Published online: 20 May 2014
AbstractforGeneration and characterization of an analog-sensitive PERK allele | Full Text | References | PDF (1.2 MB)
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