OncoImmunology, Volume 7, Issue 1 (2018)

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OncoImmunology, Volume 7, Issue 1 (2018)

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Point of View

Opinion
TNFR2: The new Treg switch?
José L. Cohen & Kathryn J. Wood
Article: e1373236
Published online: 21 Sep 2017
AbstractforTNFR2: The new Treg switch? | Full Text | References | PDF (505.7 KB)
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Brief Report

Brief Report
mSA2 affinity-enhanced biotin-binding CAR T cells for universal tumor targeting
Jason J. Lohmueller, James D. Ham, Michael Kvorjak & Olivera J. Finn
Article: e1368604
Published online: 26 Oct 2017
AbstractformSA2 affinity-enhanced biotin-binding CAR T cells for universal tumor targeting | Full Text | References | PDF (1 MB) | Supplemental
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Editorial

Editorial
Sunitinib represses regulatory T cells to overcome immunotolerance in a murine model of hepatocellular cancer
Dai Liu, Guangfu Li, Diego M. Avella, Eric T. Kimchi, Jussuf T. Kaifi, Mark P. Rubinstein, E. Ramsay Camp, Don C. Rockey, Todd D. Schell & Kevin F. Staveley-O'Carroll
Article: e1372079
Published online: 21 Sep 2017
AbstractforSunitinib represses regulatory T cells to overcome immunotolerance in a murine model of hepatocellular cancer | Full Text | References | PDF (1.1 MB) | Supplemental
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Original Research

Article
T cell inhibitory mechanisms in a model of aggressive Non-Hodgkin's Lymphoma
Tamara Hilmenyuk, Carla A. Ruckstuhl, Michael Hayoz, Christian Berchtold, Jean-Marc Nuoffer, Shyam Solanki, Hector C. Keun, Paul A. Beavis, Carsten Riether & Adrian F. Ochsenbein
Article: e1365997
Published online: 21 Sep 2017
AbstractforT cell inhibitory mechanisms in a model of aggressive Non-Hodgkin's Lymphoma | Full Text | References | PDF (2.3 MB) | Supplemental
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Article
The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma
Lennart Lenk, Maren Pein, Olga Will, Beatriz Gomez, Fabrice Viol, Charlotte Hauser, Jan-Hendrik Egberts, Jan-Paul Gundlach, Ole Helm, Sanjay Tiwari, Ralf Weiskirchen, Stefan Rose-John, Christoph Röcken, Wolfgang Mikulits, Patrick Wenzel, Günter Schneider, Dieter Saur, Heiner Schäfer & Susanne Sebens
Article: e1368603
Published online: 26 Oct 2017
AbstractforThe hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma | Full Text | References | PDF (1.4 MB) | Supplemental
  • 2204 Views
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Article
Deubiquitinases A20 and CYLD modulate costimulatory signaling via CD137 (4–1BB)
Arantza Azpilikueta, Elixabet Bolaños, Valerie Lang, Sara Labiano, Maria A. Aznar, Iñaki Etxeberria, Alvaro Teijeira, Maria E. Rodriguez-Ruiz, Jose L. Perez-Gracia, Maria Jure-Kunkel, Juan M. Zapata, Manuel S. Rodriguez & Ignacio Melero
Article: e1368605
Published online: 21 Sep 2017
AbstractforDeubiquitinases A20 and CYLD modulate costimulatory signaling via CD137 (4–1BB) | Full Text | References | PDF (1.1 MB) | Supplemental
  • 1397 Views
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Article
TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia
Kemal Catakovic, Franz Josef Gassner, Christoph Ratswohl, Nadja Zaborsky, Stefan Rebhandl, Maria Schubert, Markus Steiner, Julia Christine Gutjahr, Lisa Pleyer, Alexander Egle, Tanja Nicole Hartmann, Richard Greil & Roland Geisberger
Article: e1371399
Published online: 21 Sep 2017
AbstractforTIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia | Full Text | References | PDF (1,013 KB) | Supplemental
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Article
A library-based screening method identifies neoantigen-reactive T cells in peripheral blood prior to relapse of ovarian cancer
Spencer D. Martin, Darin A. Wick, Julie S. Nielsen, Nicole Little, Robert A. Holt & Brad H. Nelson
Article: e1371895
Published online: 21 Sep 2017
AbstractforA library-based screening method identifies neoantigen-reactive T cells in peripheral blood prior to relapse of ovarian cancer | Full Text | References | PDF (1.1 MB) | Supplemental
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Article
BTN3A is a prognosis marker and a promising target for Vγ9Vδ2 T cells based-immunotherapy in pancreatic ductal adenocarcinoma (PDAC)
Audrey Benyamine, Céline Loncle, Etienne Foucher, Juan-Luis Blazquez, Céline Castanier, Anne-Sophie Chrétien, Mauro Modesti, Véronique Secq, Salem Chouaib, Meritxell Gironella, Elena Vila-Navarro, Giuseppe Montalto, Jean-Charles Dagorn, Nelson Dusetti, Juan Iovanna & Daniel Olive
Article: e1372080
Published online: 21 Sep 2017
AbstractforBTN3A is a prognosis marker and a promising target for Vγ9Vδ2 T cells based-immunotherapy in pancreatic ductal adenocarcinoma (PDAC) | Full Text | References | PDF (1.4 MB) | Supplemental
  • 2495 Views
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Article
Langerhans-type dendritic cells electroporated with TRP-2 mRNA stimulate cellular immunity against melanoma: Results of a phase I vaccine trial
David J. Chung, Richard D. Carvajal, Michael A. Postow, Sneh Sharma, Katherine B. Pronschinske, Justin A. Shyer, Shahnaz Singh-Kandah, Mark A. Dickson, Sandra P. D'Angelo, Jedd D. Wolchok & James W. Young
Article: e1372081
Published online: 21 Sep 2017
AbstractforLangerhans-type dendritic cells electroporated with TRP-2 mRNA stimulate cellular immunity against melanoma: Results of a phase I vaccine trial | Full Text | References | PDF (1 MB) | Supplemental
  • 1450 Views
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Article
Toll-like receptor 2 ligand and interferon-γ suppress anti-tumor T cell responses by enhancing the immunosuppressive activity of monocytic myeloid-derived suppressor cells
Hiroaki Shime, Akira Maruyama, Sumito Yoshida, Yohei Takeda, Misako Matsumoto & Tsukasa Seya
Article: e1373231
Published online: 21 Sep 2017
AbstractforToll-like receptor 2 ligand and interferon-γ suppress anti-tumor T cell responses by enhancing the immunosuppressive activity of monocytic myeloid-derived suppressor cells | Full Text | References | PDF (1.5 MB) | Supplemental
  • 2790 Views
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Article
Neuroblastoma chemotherapy can be augmented by immunotargeting O-acetyl-GD2 tumor-associated ganglioside
S. Faraj, M. Bahri, S. Fougeray, A. El Roz, J. Fleurence, J. Véziers, M. D. Leclair, E. Thébaud, F. Paris & S. Birklé
Article: e1373232
Published online: 21 Sep 2017
AbstractforNeuroblastoma chemotherapy can be augmented by immunotargeting O-acetyl-GD2 tumor-associated ganglioside | Full Text | References | PDF (1.2 MB) | Supplemental
  • 1660 Views
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Article
IL-17 induces antitumor immunity by promoting beneficial neutrophil recruitment and activation in esophageal squamous cell carcinoma
Chang-Long Chen, Ying Wang, Chun-Yu Huang, Zi-Qi Zhou, Jing-Jing Zhao, Xiao-Fei Zhang, Qiu-Zhong Pan, Jiang-Xue Wu, De-Sheng Weng, Yan Tang, Qian Zhu, Lu-Ping Yuan & Jian-Chuan Xia
Article: e1373234
Published online: 21 Sep 2017
AbstractforIL-17 induces antitumor immunity by promoting beneficial neutrophil recruitment and activation in esophageal squamous cell carcinoma | Full Text | References | PDF (1.3 MB) | Supplemental
  • 2028 Views
  • 37 CrossRef citations
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Article
The “don't eat me” signal CD47 is a novel diagnostic biomarker and potential therapeutic target for diffuse malignant mesothelioma
Christian M. Schürch, Stefan Forster, Frido Brühl, Sara H. Yang, Emanuela Felley-Bosco & Ekkehard Hewer
Article: e1373235
Published online: 21 Sep 2017
AbstractforThe “don't eat me” signal CD47 is a novel diagnostic biomarker and potential therapeutic target for diffuse malignant mesothelioma | Full Text | References | PDF (1.7 MB) | Supplemental
  • 3068 Views
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Article
Small molecule GL-V9 protects against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy
Yue Zhao, Qinglong Guo, Kai Zhao, Yuxin Zhou, Wenjun Li, Chuyue Pan, Lei Qiang, Zhiyu Li & Na Lu
Article: e1375640
Published online: 21 Sep 2017
AbstractforSmall molecule GL-V9 protects against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy | Full Text | References | PDF (1.8 MB) | Supplemental
  • 1973 Views
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Article
A bispecific nanobody approach to leverage the potent and widely applicable tumor cytolytic capacity of Vγ9Vδ2-T cells
Renée C. G. de Bruin, John P. Veluchamy, Sinéad M. Lougheed, Famke L. Schneiders, Silvia Lopez-Lastra, Roeland Lameris, Anita G. Stam, Zsolt Sebestyen, Jürgen Kuball, Carla F. M. Molthoff, Erik Hooijberg, Rob C. Roovers, James P. Di Santo, Paul M. P. van Bergen en Henegouwen, Henk M. W. Verheul, Tanja D. de Gruijl & Hans J. van der Vliet
Article: e1375641
Published online: 20 Oct 2017
AbstractforA bispecific nanobody approach to leverage the potent and widely applicable tumor cytolytic capacity of Vγ9Vδ2-T cells | Full Text | References | PDF (1.1 MB) | Supplemental
  • 5157 Views
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Article
Development of thyroid dysfunction is associated with clinical response to PD-1 blockade treatment in patients with advanced non-small cell lung cancer
Hye In Kim, Mijin Kim, Se-Hoon Lee, So Young Park, Young Nam Kim, Hosu Kim, Min Ji Jeon, Tae Yong Kim, Sun Wook Kim, Won Bae Kim, Sang-We Kim, Dae Ho Lee, Keunchil Park, Myung-Ju Ahn, Jae Hoon Chung, Young Kee Shong, Won Gu Kim & Tae Hyuk Kim
Article: e1375642
Published online: 21 Sep 2017
AbstractforDevelopment of thyroid dysfunction is associated with clinical response to PD-1 blockade treatment in patients with advanced non-small cell lung cancer | Full Text | References | PDF (577.6 KB) | Supplemental
  • 1893 Views
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Article
Elevated levels of extracellular vesicles are associated with therapy failure and disease progression in breast cancer patients undergoing neoadjuvant chemotherapy
Lisa König, Sabine Kasimir-Bauer, Ann-Kathrin Bittner, Oliver Hoffmann, Bettina Wagner, Luis Felipe Santos Manvailer, Rainer Kimmig, Peter A. Horn & Vera Rebmann
Article: e1376153
Published online: 27 Sep 2017
AbstractforElevated levels of extracellular vesicles are associated with therapy failure and disease progression in breast cancer patients undergoing neoadjuvant chemotherapy | Full Text | References | PDF (684.3 KB) | Supplemental
  • 2008 Views
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Article
Blocking CTLA-4 while priming with a whole cell vaccine reshapes the oligoclonal T cell infiltrate and eradicates tumors in an orthotopic glioma model
Cameron S. Field, Martin K. Hunn, Peter M. Ferguson, Christiane Ruedl, Lindsay R. Ancelet & Ian F. Hermans
Article: e1376154
Published online: 27 Sep 2017
AbstractforBlocking CTLA-4 while priming with a whole cell vaccine reshapes the oligoclonal T cell infiltrate and eradicates tumors in an orthotopic glioma model | Full Text | References | PDF (1.5 MB) | Supplemental
  • 1472 Views
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Article
Crk adaptor protein promotes PD-L1 expression, EMT and immune evasion in a murine model of triple-negative breast cancer
Sushil Kumar, Viralkumar Davra, Alison E. Obr, Ke Geng, Teresa L. Wood, Mariana S. De Lorenzo & Raymond B. Birge
Article: e1376155
Published online: 27 Sep 2017
AbstractforCrk adaptor protein promotes PD-L1 expression, EMT and immune evasion in a murine model of triple-negative breast cancer | Full Text | References | PDF (1.3 MB)
  • 2322 Views
  • 23 CrossRef citations
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Article
Overcoming resistance to anti-PD immunotherapy in a syngeneic mouse lung cancer model using locoregional virotherapy
Xiang Yan, Li Wang, Ran Zhang, Xingxiang Pu, Shuhong Wu, Lili Yu, Ismail M. Meraz, Xiaoshan Zhang, Jacqueline F. Wang, Don L. Gibbons, Reza J. Mehran, Stephen G. Swisher, Jack A. Roth & Bingliang Fang
Article: e1376156
Published online: 31 Oct 2017
AbstractforOvercoming resistance to anti-PD immunotherapy in a syngeneic mouse lung cancer model using locoregional virotherapy | Full Text | References | PDF (891.2 KB)
  • 2353 Views
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Article
Phase I study of glypican-3-derived peptide vaccine therapy for patients with refractory pediatric solid tumors
Nobuhiro Tsuchiya, Ako Hosono, Toshiaki Yoshikawa, Kayoko Shoda, Kazuto Nosaka, Manami Shimomura, Junichi Hara, Chika Nitani, Atsushi Manabe, Hiroki Yoshihara, Yosuke Hosoya, Hide Kaneda, Yoshiaki Kinoshita, Kenichi Kohashi, Kenichi Yoshimura, Norihiro Fujinami, Keigo Saito, Shoichi Mizuno & Tetsuya Nakatsura
Article: e1377872
Published online: 27 Sep 2017
AbstractforPhase I study of glypican-3-derived peptide vaccine therapy for patients with refractory pediatric solid tumors | Full Text | References | PDF (1.3 MB) | Supplemental
  • 2098 Views
  • 35 CrossRef citations
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Article
Interleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models
Katherine E. Lewis, Mark J. Selby, Gregg Masters, Jose Valle, Gennaro Dito, Wendy R. Curtis, Richard Garcia, Kathy A. Mink, Kimberly S. Waggie, Matthew S. Holdren, Joseph F. Grosso, Alan J. Korman, Maria Jure-Kunkel & Stacey R. Dillon
Article: e1377873
Published online: 04 Oct 2017
AbstractforInterleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models | Full Text | References | PDF (1.6 MB) | Supplemental
  • 5604 Views
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Article
ATTACK, a novel bispecific T cell-recruiting antibody with trivalent EGFR binding and monovalent CD3 binding for cancer immunotherapy
Seandean Lykke Harwood, Ana Alvarez-Cienfuegos, Natalia Nuñez-Prado, Marta Compte, Sara Hernández-Pérez, Nekane Merino, Jaume Bonet, Rocio Navarro, Paul M. P. Van Bergen en Henegouwen, Simon Lykkemark, Kasper Mikkelsen, Kasper Mølgaard, Frederic Jabs, Laura Sanz, Francisco J. Blanco, Pedro Roda-Navarro & Luis Alvarez-Vallina
Article: e1377874
Published online: 27 Sep 2017
AbstractforATTACK, a novel bispecific T cell-recruiting antibody with trivalent EGFR binding and monovalent CD3 binding for cancer immunotherapy | Full Text | References | PDF (1.4 MB) | Supplemental
  • 7168 Views
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Article
Intra-tumoral production of IL18, but not IL12, by TCR-engineered T cells is non-toxic and counteracts immune evasion of solid tumors
A. Kunert, M. Chmielewski, R. Wijers, C. Berrevoets, H. Abken & R. Debets
Article: e1378842
Published online: 11 Oct 2017
AbstractforIntra-tumoral production of IL18, but not IL12, by TCR-engineered T cells is non-toxic and counteracts immune evasion of solid tumors | Full Text | References | PDF (1.2 MB) | Supplemental
  • 3442 Views
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Article
Bevacizumab-mediated tumor vasculature remodelling improves tumor infiltration and antitumor efficacy of GD2-CAR T cells in a human neuroblastoma preclinical model
Paola Bocca, Emma Di Carlo, Ignazio Caruana, Laura Emionite, Michele Cilli, Biagio De Angelis, Concetta Quintarelli, Annalisa Pezzolo, Lizzia Raffaghello, Fabio Morandi, Franco Locatelli, Vito Pistoia & Ignazia Prigione
Article: e1378843
Published online: 04 Oct 2017
AbstractforBevacizumab-mediated tumor vasculature remodelling improves tumor infiltration and antitumor efficacy of GD2-CAR T cells in a human neuroblastoma preclinical model | Full Text | References | PDF (1.4 MB) | Supplemental
  • 2972 Views
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Article
IL-21 promotes the development of a CD73-positive Vγ9Vδ2 T cell regulatory population
Clément Barjon, Henri-Alexandre Michaud, Angeline Fages, Cécile Dejou, Alexandre Zampieri, Laetitia They, Aurélie Gennetier, Françoise Sanchez, Laurent Gros, Jean-François Eliaou, Nathalie Bonnefoy & Virginie Lafont
Article: e1379642
Published online: 04 Oct 2017
AbstractforIL-21 promotes the development of a CD73-positive Vγ9Vδ2 T cell regulatory population | Full Text | References | PDF (783.3 KB)
  • 1779 Views
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Article
CD89-mediated recruitment of macrophages via a bispecific antibody enhances anti-tumor efficacy
Bingyu Li, Lijun Xu, Chenyu Pi, Yanxin Yin, Kun Xie, Fei Tao, Renhao Li, Hua Gu & Jianmin Fang
Article: e1380142
Published online: 12 Oct 2017
AbstractforCD89-mediated recruitment of macrophages via a bispecific antibody enhances anti-tumor efficacy | Full Text | References | PDF (781.5 KB)
  • 2754 Views
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Review

Review
PD-1 expression on tumor-specific T cells: Friend or foe for immunotherapy?
Sylvain Simon & Nathalie Labarriere
Article: e1364828
Published online: 14 Sep 2017
AbstractforPD-1 expression on tumor-specific T cells: Friend or foe for immunotherapy? | Full Text | References | PDF (630.3 KB)
  • 11139 Views
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Review
PD-L1 inhibitors in the pipeline: Promise and progress
Vito Vanella, Lucia Festino, Martina Strudel, Ester Simeone, Antonio M. Grimaldi & Paolo A. Ascierto
Article: e1365209
Published online: 21 Sep 2017
AbstractforPD-L1 inhibitors in the pipeline: Promise and progress | Full Text | References | PDF (561 KB)
  • 2305 Views
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Corrigendum

Correction
Corrigendum
Article: e1412885
Published online: 19 Dec 2017
CitationforCorrigendum | Full Text | PDF (101.2 KB)
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Correction
Corrigendum
Article: e1413845
Published online: 19 Dec 2017
CitationforCorrigendum | Full Text | PDF (103.7 KB)
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Correction
Corrigendum
Article: e1413855
Published online: 19 Dec 2017
CitationforCorrigendum | Full Text | PDF (102.1 KB)
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