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Romeo Romagnoli, Tiziano De Ventura, Stefano Manfredini, Erika Baldini, Claudiu T. Supuran, Alessio Nocentini, Andrea Brancale, Roberta Bortolozzi, Lorenzo Manfreda & Giampietro Viola. (2023) Design, synthesis, and biological investigation of selective human carbonic anhydrase II, IX, and XII inhibitors using 7-aryl/heteroaryl triazolopyrimidines bearing a sulfanilamide scaffold. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Heba Abdelrasheed Allam, Mohamed E. Albakry, Walaa R. Mahmoud, Alessandro Bonardi, Shaimaa A. Moussa, Samy Mohamady, Hatem A. Abdel-Aziz, Claudiu T. Supuran & Hany S. Ibrahim. (2023) Effect of hydrophobic extension of aryl enaminones and pyrazole-linked compounds combined with sulphonamide, sulfaguanidine, or carboxylic acid functionalities on carbonic anhydrase inhibitory potency and selectivity. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Francesco Fiorentino, Alessio Nocentini, Dante Rotili, Claudiu T. Supuran & Antonello Mai. (2023) Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Özcan Güleç, Cüneyt Türkeş, Mustafa Arslan, Yeliz Demir, Busra Dincer, Abdulilah Ece & Şükrü Beydemir. (2023) Novel beta-lactam substituted benzenesulfonamides: in vitro enzyme inhibition, cytotoxic activity and in silico interactions. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-19.
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Satyajit Khatua & Srabani Taraphder. (2023) In the footsteps of an inhibitor unbinding from the active site of human carbonic anhydrase II. Journal of Biomolecular Structure and Dynamics 41:8, pages 3187-3204.
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Clemente Capasso & Claudiu T. Supuran. (2023) The management of Babesia, amoeba and other zoonotic diseases provoked by protozoa. Expert Opinion on Therapeutic Patents 33:3, pages 179-192.
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Andrea Angeli, Linda J Urbański, Clemente Capasso, Seppo Parkkila & Claudiu T. Supuran. (2022) Activation studies with amino acids and amines of a β-carbonic anhydrase from Mammaliicoccus (Staphylococcus) sciuri previously annotated as Staphylococcus aureus (SauBCA) carbonic anhydrase. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2786-2792.
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Morteza Abdoli, Simone Giovannuzzi, Claudiu T. Supuran & Raivis Žalubovskis. (2022) 4-(3-Alkyl/benzyl-guanidino)benzenesulfonamides as selective carbonic anhydrase VII inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1568-1576.
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Kiran Siwach, Amit Kumar, Harish Panchal, Rajiv Kumar, Jitender Kumar Bhardwaj, Andrea Angeli, Claudiu T. Supuran & Pawan K. Sharma. (2022) Selective inhibition of carbonic anhydrase IX by sulphonylated 1,2,3-triazole incorporated benzenesulphonamides capable of inducing apoptosis. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1454-1463.
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Varun Chahal, Sonam Nirwan, Mallika Pathak & Rita Kakkar. (2022) Identification of potent human carbonic anhydrase IX inhibitors: a combination of pharmacophore modeling, 3D-QSAR, virtual screening and molecular dynamics simulations. Journal of Biomolecular Structure and Dynamics 40:10, pages 4516-4531.
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Chandra Bhushan Mishra, Raj Kumar Mongre, Amresh Prakash, Raok Jeon, Claudiu T. Supuran & Myeong-Sok Lee. (2021) Anti-breast cancer action of carbonic anhydrase IX inhibitor 4-[4-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-benzylidene-hydrazinocarbonyl]-benzenesulfonamide (BSM-0004): in vitro and in vivo studies. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 954-963.
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Andrea Angeli, Linda J. Urbański, Vesa P. Hytönen, Seppo Parkkila & Claudiu T. Supuran. (2021) Activation of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with amines and amino acids. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 758-763.
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Alessio Nocentini, Andrea Angeli, Fabrizio Carta, Jean-Yves Winum, Raivis Zalubovskis, Simone Carradori, Clemente Capasso, William A. Donald & Claudiu T. Supuran. (2021) Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 561-580.
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Andrea Petreni, Viviana De Luca, Andrea Scaloni, Alessio Nocentini, Clemente Capasso & Claudiu T. Supuran. (2021) Anion inhibition studies of the Zn(II)-bound ι-carbonic anhydrase from the Gram-negative bacterium Burkholderia territorii. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 372-376.
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Linda J. Urbański, Andrea Angeli, Vesa P. Hytönen, Anna Di Fiore, Giuseppina De Simone, Seppo Parkkila & Claudiu T. Supuran. (2021) Inhibition of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with sulphonamides. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 330-335.
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Claudiu T Supuran. (2020) Experimental Carbonic Anhydrase Inhibitors for the Treatment of Hypoxic Tumors. Journal of Experimental Pharmacology 12, pages 603-617.
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Claudiu T. Supuran. (2020) Exploring the multiple binding modes of inhibitors to carbonic anhydrases for novel drug discovery. Expert Opinion on Drug Discovery 15:6, pages 671-686.
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Claudiu T. Supuran. (2020) An update on drug interaction considerations in the therapeutic use of carbonic anhydrase inhibitors. Expert Opinion on Drug Metabolism & Toxicology 16:4, pages 297-307.
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Ercan Soydan, Ahmet Can Olcay, Gürkan Bilir, Ömer Taş, Murat Şentürk, Deniz Ekinci & Claudiu T. Supuran. (2020) Investigation of pesticides on honey bee carbonic anhydrase inhibition. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1923-1927.
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Paolo Guglielmi, Giulia Rotondi, Daniela Secci, Andrea Angeli, Paola Chimenti, Alessio Nocentini, Alessandro Bonardi, Paola Gratteri, Simone Carradori & Claudiu T. Supuran. (2020) Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1891-1905.
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Doretta Cuffaro, Elisa Nuti & Armando Rossello. (2020) An overview of carbohydrate-based carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1906-1922.
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Claudiu T. Supuran. (2020) Coumarin carbonic anhydrase inhibitors from natural sources. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1462-1470.
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Patrizio Blandina, Gustavo Provensi, Maria Beatrice Passani, Clemente Capasso & Claudiu T. Supuran. (2020) Carbonic anhydrase modulation of emotional memory. Implications for the treatment of cognitive disorders. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1206-1214.
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Mehmet Oguz, Erbay Kalay, Suleyman Akocak, Alessio Nocentini, Nebih Lolak, Mehmet Boga, Mustafa Yilmaz & Claudiu T. Supuran. (2020) Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1215-1223.
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Aleksandrs Pustenko, Alessio Nocentini, Paola Gratteri, Alessandro Bonardi, Igor Vozny, Raivis Žalubovskis & Claudiu T. Supuran. (2020) The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1011-1020.
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Hasan Küçükbay, Zeynep Gönül, F. Zehra Küçükbay, Andrea Angeli, Gianluca Bartolucci & Claudiu T. Supuran. (2020) Preparation, carbonic anhydrase enzyme inhibition and antioxidant activity of novel 7-amino-3,4-dihydroquinolin-2(1H)-one derivatives incorporating mono or dipeptide moiety. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1021-1026.
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Mustafa Durgun, Cüneyt Türkeş, Mesut Işık, Yeliz Demir, Ali Saklı, Ali Kuru, Abdussamat Güzel, Şükrü Beydemir, Suleyman Akocak, Sameh M. Osman, Zeid AlOthman & Claudiu T. Supuran. (2020) Synthesis, characterisation, biological evaluation and in silico studies of sulphonamide Schiff bases. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 950-962.
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Andrea Angeli, Sonia Del Prete, Cynthia Ghobril, Julien Hitce, Cécile Clavaud, Xavier Marrat, William A. Donald, Clemente Capasso & Claudiu T. Supuran. (2020) Activation studies of the β-carbonic anhydrases from Malassezia restricta with amines and amino acids. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 824-830.
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Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Silvia Bua, Alessio Nocentini, Nawaf A. AlSaif, Mohammed M. Alanazi, Manal A. El-Gendy, Hany E. A. Ahmed & Claudiu T. Supuran. (2020) S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 733-743.
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Jeremie Brichet, Rodrigo Arancibia, Emanuela Berrino & Claudiu T. Supuran. (2020) Bioorganometallic derivatives of 4-hydrazino-benzenesulphonamide as carbonic anhydrase inhibitors: synthesis, characterisation and biological evaluation. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 622-628.
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Aleksandrs Pustenko, Alessio Nocentini, Anastasija Balašova, Mikhail Krasavin, Raivis Žalubovskis & Claudiu T. Supuran. (2020) 7-Acylamino-3H-1,2-benzoxathiepine 2,2-dioxides as new isoform-selective carbonic anhydrase IX and XII inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 650-656.
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Rakia Abd Alhameed, Emanuela Berrino, Zainab Almarhoon, Ayman El-Faham & Claudiu T. Supuran. (2020) A class of carbonic anhydrase IX/XII – selective carboxylate inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 549-554.
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Hasan Küçükbay, Nesrin Buğday, F. Zehra Küçükbay, Andrea Ageli, Gianluca Bartolucci & Claudiu T. Supuran. (2020) Synthesis and human carbonic anhydrase I, II, VA, and XII inhibition with novel amino acid–sulphonamide conjugates. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 489-497.
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Nabih Lolak, Mehmet Boga, Muhammed Tuneg, Gulcin Karakoc, Suleyman Akocak & Claudiu T. Supuran. (2020) Sulphonamides incorporating 1,3,5-triazine structural motifs show antioxidant, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory profile. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 424-431.
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Siham A. Alissa, Hanan A. Alghulikah, Zeid A. ALOthman, Sameh M. Osman, Sonia Del Prete, Clemente Capasso, Alessio Nocentini & Claudiu T. Supuran. (2020) Inhibition survey with phenolic compounds against the δ- and η-class carbonic anhydrases from the marine diatom thalassiosira weissflogii and protozoan Plasmodium falciparum. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 377-382.
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Sinan Bilginer, Baris Gonder, Halise Inci Gul, Ruya Kaya, Ilhami Gulcin, Baris Anil & Claudiu T. Supuran. (2020) Novel sulphonamides incorporating triazene moieties show powerful carbonic anhydrase I and II inhibitory properties. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 325-329.
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Ali Irfan, Fozia Batool, Syeda Andleeb Zahra Naqvi, Amjad Islam, Sameh M. Osman, Alessio Nocentini, Siham A. Alissa & Claudiu T. Supuran. (2020) Benzothiazole derivatives as anticancer agents. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 265-279.
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Siham A. Alissa, Hanan A. Alghulikah, Zeid A. Alothman, Sameh M. Osman, Sonia Del Prete, Clemente Capasso, Alessio Nocentini & Claudiu T. Supuran. (2020) Phosphonamidates are the first phosphorus-based zinc binding motif to show inhibition of β-class carbonic anhydrases from bacteria, fungi, and protozoa. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 59-64.
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Claudiu T Supuran. (2019) The management of glaucoma and macular degeneration. Expert Opinion on Therapeutic Patents 29:10, pages 745-747.
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Articles from other publishers (79)
Cüneyt Türkeş. (2023) Carbonic anhydrase inhibition by antiviral drugs in vitro and in silico. Journal of Molecular Recognition 36:12.
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Domiziana Masci, Michela Puxeddu, Laura Di Magno, Michele D’Ambrosio, Anastasia Parisi, Marianna Nalli, Ruoli Bai, Antonio Coluccia, Pietro Sciò, Viviana Orlando, Sara D’Angelo, Stefano Biagioni, Andrea Urbani, Ernest Hamel, Alessio Nocentini, Serena Filiberti, Marta Turati, Roberto Ronca, Joanna Kopecka, Chiara Riganti, Cinzia Fionda, Rosa Bordone, Giorgia Della Rocca, Gianluca Canettieri, Claudiu T. Supuran, Romano Silvestri & Giuseppe La Regina. (2023)
4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1
H
-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells
. Journal of Medicinal Chemistry 66:21, pages 14824-14842.
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Lalit Vats, Priyanka Arya, Rajiv Kumar, Simone Giovannuzzi, Neera Raghav, Claudiu T Supuran & Pawan K Sharma. (2023) Keto-bridged dual triazole-linked benzenesulfonamides as potent carbonic anhydrase and cathepsin B inhibitors. Future Medicinal Chemistry.
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Federico Ricci, Andrea Angeli, Francesca Mancuso, Laura De Luca, Claudiu T. Supuran & Rosaria Gitto. (2023) Screening Campaign and Docking Investigations in Identifying New Hit Compounds as Inhibitors of Human Carbonic Anhydrases Expressed In Tumour Cells. ChemMedChem 18:20.
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Ayse Er. (2023) Various Carbonic Anhydrases in Physiopathological Events, Carbonic
Anhydrase Inhibitors, and Hybrid Compounds. Letters in Drug Design & Discovery 20:10, pages 1427-1436.
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Paloma Begines, Alessandro Bonardi, Alessio Nocentini, Paola Gratteri, Simone Giovanuzzi, Roberto Ronca, Camilla Tavani, Maria Luisa Massardi, Óscar López & Claudiu T. Supuran. (2023) Design and synthesis of sulfonamides incorporating a biotin moiety: carbonic anhydrase inhibitory effects, antiproliferative activity and molecular modeling studies. Bioorganic & Medicinal Chemistry, pages 117467.
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Aida Buza, Cüneyt Türkeş, Mustafa Arslan, Yeliz Demir, Busra Dincer, Arleta Rifati Nixha & Şükrü Beydemir. (2023) Discovery of novel benzenesulfonamides incorporating 1,2,3-triazole scaffold as carbonic anhydrase I, II, IX, and XII inhibitors. International Journal of Biological Macromolecules 239, pages 124232.
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Heba M. Metwally, Heba Abdelrasheed Allam, Fady Baselious, Alessandro Bonardi, Emad M. Seif, Shaimaa A. Moussa, Ehab Abdel-Latif, Claudiu T. Supuran & Hany S. Ibrahim. (2023) Arylidine extensions of 3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-benzenesulfonamide derivatives: Synthesis, computational simulations and biological evaluation as tumor-associated carbonic anhydrase inhibitors. Bioorganic Chemistry 135, pages 106492.
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Jekateri̅na Ivanova, Alessio Nocentini, Kaspars Ta̅rs, Ja̅nis Leita̅ns, Elviss Dvinskis, Andris Kazaks, Ilona Domračeva, Claudiu T. Supuran & Raivis Žalubovskis. (2023) Atropo/Tropo Flexibility: A Tool for Design and Synthesis of Self-Adaptable Inhibitors of Carbonic Anhydrases and Their Antiproliferative Effect. Journal of Medicinal Chemistry 66:8, pages 5703-5718.
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Tingting Hu, Jifa Zhang, Jiaxing Wang, Leihao Sha, Yilin Xia, Tyler C. Ortyl, Xiaohe Tian & Lei Chen. (2023) Advances in Epilepsy: Mechanisms, Clinical Trials, and Drug Therapies. Journal of Medicinal Chemistry 66:7, pages 4434-4467.
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Conor B. O’Herin, Yuta W. Moriuchi, Troy A. Bemis, Alysia J. Kohlbrand, Michael D. Burkart & Seth M. Cohen. (2023) Development of Human Carbonic Anhydrase II Heterobifunctional Degraders. Journal of Medicinal Chemistry 66:4, pages 2789-2803.
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Emanuela Berrino, Laura Micheli, Simone Carradori, Lorenzo di Cesare Mannelli, Paolo Guglielmi, Alessandro De Luca, Fabrizio Carta, Carla Ghelardini, Daniela Secci & Claudiu T. Supuran. (2023) Novel Insights on CAI–CORM Hybrids: Evaluation of the CO Releasing Properties and Pain-Relieving Activity of Differently Substituted Coumarins for the Treatment of Rheumatoid Arthritis. Journal of Medicinal Chemistry 66:3, pages 1892-1908.
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Andrea Angeli, Anthi Petrou, Victor Kartsev, Boris Lichitsky, Andrey Komogortsev, Clemente Capasso, Athina Geronikaki & Claudiu T. Supuran. (2023) Synthesis, Biological and In Silico Studies of Griseofulvin and Usnic Acid Sulfonamide Derivatives as Fungal, Bacterial and Human Carbonic Anhydrase Inhibitors. International Journal of Molecular Sciences 24:3, pages 2802.
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Chnar Kakakhan, Cüneyt Türkeş, Özcan Güleç, Yeliz Demir, Mustafa Arslan, Gizem Özkemahlı & Şükrü Beydemir. (2023) Exploration of 1,2,3-triazole linked benzenesulfonamide derivatives as isoform selective inhibitors of human carbonic anhydrase. Bioorganic & Medicinal Chemistry 77, pages 117111.
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Vikas Sharma, Rajiv Kumar, Andrea Angeli, Claudiu T. Supuran & Pawan K. Sharma. (2022) Benzenesulfonamides with trisubstituted triazole motif as selective carbonic anhydrase I, II, IV, and IX inhibitors. Archiv der Pharmazie 356:1.
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Laura De Luca, Andrea Angeli, Federico Ricci, Claudiu T. Supuran & Rosaria Gitto. (2022) Structure‐guided identification of a selective sulfonamide‐based inhibitor targeting the human carbonic anhydrase VA isoform. Archiv der Pharmazie 356:1.
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Yuhong Jiang, Claudiu T. Supuran & Junming Ho. (2022) Quantum Chemical Prediction of the Acidities of Sulfonamide Inhibitors of Carbonic Anhydrase. The Journal of Physical Chemistry A 126:49, pages 9207-9217.
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Alessandro Bonardi, Claudiu T. Supuran & Alessio Nocentini. 2022. Flavonoids and Phenolics. Flavonoids and Phenolics
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Claudiu T. Supuran. 2022. Flavonoids and Phenolics. Flavonoids and Phenolics
298
329
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Shoaib Manzoor, Andrea Angeli, Susi Zara, Simone Carradori, Md Ataur Rahman, Md Kausar Raza, Claudiu T. Supuran & Nasimul Hoda. (2022) Development of benzene and benzothiazole-sulfonamide analogues as selective inhibitors of the tumor-associated carbonic anhydrase IX. European Journal of Medicinal Chemistry 243, pages 114793.
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Majid Khan, Satya Kumar Avula, Sobia Ahsan Halim, Muhammad Waqas, Mufarreh Asmari, Ajmal Khan & Ahmed Al-Harrasi. (2022) Biochemical and in silico inhibition of bovine and human carbonic anhydrase-II by 1H-1,2,3-triazole analogs. Frontiers in Chemistry 10.
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Aarfa Queen, Humaira Naaz Bhutto, Mohd Yousuf, Mansoor Ali Syed & Md. Imtaiyaz Hassan. (2022) Carbonic anhydrase IX: A tumor acidification switch in heterogeneity and chemokine regulation. Seminars in Cancer Biology 86, pages 899-913.
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Heba T. Abdel‐Mohsen, Andrea Petreni & Claudiu T. Supuran. (2022) Investigation of the carbonic anhydrase inhibitory activity of benzenesulfonamides incorporating substituted fused‐pyrimidine tails. Archiv der Pharmazie 355:11.
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Naying Chu, Yitong Wang, Hao Jia, Jie Han, Xiaoyi Wang & Zhuang Hou. (2022) Design, Synthesis and Biological Evaluation of New Carbohydrate-Based Coumarin Derivatives as Selective Carbonic Anhydrase IX Inhibitors via “Click” Reaction. Molecules 27:17, pages 5464.
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Pavitra S. Thacker, Arifuddin Mohammed, Claudiu T. Supuran, Prerna L. Tiwari, Nerella S. Goud, Danaboina Srikanth & Andrea Angeli. (2022) Synthesis and Biological Evaluation of Coumarin Carboxamides as Selective and
Potent Inhibitors of Carbonic Anhydrases IX and XII. Anti-Cancer Agents in Medicinal Chemistry 22:14, pages 2647-2654.
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Peng Lin, Junpeng Shi, Liyan Ming, Yangyang Sheng, Liang Song, Maochun Hong & Yun Zhang. (2022) An intelligent persistent luminescence nanoplatform with high-efficiency O2 utilization for continuous hypoxic tumors treatment. Chemical Engineering Journal 442, pages 135638.
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Zhenzhen Zhou, Jiajie Qian, Archana Kini, Brigitte Riederer, Dorothee Römermann, Gerolf Gros & Ursula Seidler. (2022) Loss of luminal carbonic anhydrase XIV results in decreased biliary bicarbonate output, liver fibrosis, and cholangiocyte proliferation in mice. Pflügers Archiv - European Journal of Physiology 474:5, pages 529-539.
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Baijayantimala Swain, Santosh Kumar Sahoo, Priti Singh, Andrea Angeli, Venkata Madhavi Yaddanapudi, Claudiu T. Supuran & Mohammed Arifuddin. (2022) Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases. European Journal of Medicinal Chemistry 234, pages 114247.
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Priti Singh, Dilep Kumar Sigalapalli, Nerella Sridhar Goud, Baijayantimala Swain, Santosh Kumar Sahoo, Andrea Angeli, Afzal B. Shaik, Venkata Madhavi Yaddanapudi, Claudiu T. Supuran & Mohammed Arifuddin. (2021) Ureidosulfocoumarin Derivatives As Selective and Potent Carbonic Anhydrase IX and XII Inhibitors. ChemMedChem 17:5.
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Laila Rubab, Sumbal Afroz, Sajjad Ahmad, Saddam Hussain, Iram Nawaz, Ali Irfan, Fozia Batool, Katarzyna Kotwica-Mojzych & Mariusz Mojzych. (2022) An Update on Synthesis of Coumarin Sulfonamides as Enzyme Inhibitors and Anticancer Agents. Molecules 27:5, pages 1604.
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Dongguo Xia, Hao Liu, Xiang Cheng, Manikantha Maraswami, Yiting Chen & Xianhai Lv. (2022) Recent Developments of Coumarin-based Hybrids in Drug Discovery. Current Topics in Medicinal Chemistry 22:4, pages 269-283.
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Niccolò Chiaramonte, Andrea Angeli, Silvia Sgambellone, Alessandro Bonardi, Alessio Nocentini, Gianluca Bartolucci, Laura Braconi, Silvia Dei, Laura Lucarini, Elisabetta Teodori, Paola Gratteri, Bernhard Wünsch, Claudiu T. Supuran & Maria Novella Romanelli. (2022) 2-(2-Hydroxyethyl)piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity. European Journal of Medicinal Chemistry 228, pages 114026.
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Heba T. Abdel-Mohsen, Ahmed M. El Kerdawy, Mohamed A. Omar, Andrea Petreni, Rasha M. Allam, Hoda I. El Diwani & Claudiu T. Supuran. (2022) Application of the dual-tail approach for the design and synthesis of novel Thiopyrimidine–Benzenesulfonamide hybrids as selective carbonic anhydrase inhibitors. European Journal of Medicinal Chemistry 228, pages 114004.
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Simone Giovannuzzi, Mario D’Ambrosio, Cristina Luceri, Sameh Mohamed Osman, Marco Pallecchi, Gianluca Bartolucci, Alessio Nocentini & Claudiu T. Supuran. (2021) Aromatic Sulfonamides including a Sulfonic Acid Tail: New Membrane Impermeant Carbonic Anhydrase Inhibitors for Targeting Selectively the Cancer-Associated Isoforms. International Journal of Molecular Sciences 23:1, pages 461.
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Andrea Petreni, Sameh M. Osman, Fatmah A. Alasmary, Tahani M. Almutairi, Alessio Nocentini & Claudiu T. Supuran. (2021) Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases. European Journal of Medicinal Chemistry 226, pages 113875.
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Mária Bodnár Mikulová, Dáša Kružlicová, Daniel Pecher, Andrea Petreni, Claudiu T. Supuran & Peter Mikuš. (2021) Synthesis and Inhibition Activity Study of Triazinyl-Substituted Amino(alkyl)-benzenesulfonamide Conjugates with Polar and Hydrophobic Amino Acids as Inhibitors of Human Carbonic Anhydrases I, II, IV, IX, and XII. International Journal of Molecular Sciences 22:20, pages 11283.
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Emanuela Berrino, Bastien Michelet, Agnès Martin‐Mingot, Fabrizio Carta, Claudiu T. Supuran & Sébastien Thibaudeau. (2021) Modulating the Efficacy of Carbonic Anhydrase Inhibitors through Fluorine Substitution. Angewandte Chemie International Edition 60:43, pages 23068-23082.
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Emanuela Berrino, Bastien Michelet, Agnès Martin‐Mingot, Fabrizio Carta, Claudiu T. Supuran & Sébastien Thibaudeau. (2021) Modulating the Efficacy of Carbonic Anhydrase Inhibitors through Fluorine Substitution. Angewandte Chemie 133:43, pages 23252-23266.
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Enrico Luchinat, Letizia Barbieri, Matteo Cremonini, Matteo Pennestri, Alessio Nocentini, Claudiu T. Supuran & Lucia Banci. (2021) Determination of intracellular protein–ligand binding affinity by competition binding in-cell NMR. Acta Crystallographica Section D Structural Biology 77:10, pages 1270-1281.
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Marialuigia Fantacuzzi, Marialucia Gallorini, Nicola Gambacorta, Alessandra Ammazzalorso, Zeineb Aturki, Marwa Balaha, Simone Carradori, Letizia Giampietro, Cristina Maccallini, Amelia Cataldi, Orazio Nicolotti, Rosa Amoroso & Barbara De Filippis. (2021) Design, Synthesis and Biological Evaluation of Aromatase Inhibitors Based on Sulfonates and Sulfonamides of Resveratrol. Pharmaceuticals 14:10, pages 984.
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Yassine Aimene, Romain Eychenne, Frédéric Rodriguez, Sonia Mallet-Ladeira, Nathalie Saffon-Merceron, Jean-Yves Winum, Alessio Nocentini, Claudiu T. Supuran, Eric Benoist & Achour Seridi. (2021) Synthesis, Crystal Structure, Inhibitory Activity and Molecular Docking of Coumarins/Sulfonamides Containing Triazolyl Pyridine Moiety as Potent Selective Carbonic Anhydrase IX and XII Inhibitors. Crystals 11:9, pages 1076.
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Mina Ghiasi, Samira Gholami & Samira Nasiri. (2021) QM study of carbon dioxide (CO2) and carbonyl sulfide (COS) degradation by cluster model of Carbonic anhydrase enzyme. Computational and Theoretical Chemistry 1199, pages 113188.
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Elmas Begum Cakmak, Belma Zengin Kurt, Dilek Ozturk Civelek, Andrea Angeli, Atilla Akdemir, Fatih Sonmez, Claudiu T. Supuran & Mustafa Kucukislamoglu. (2021) Quinoline-sulfamoyl carbamates/sulfamide derivatives: Synthesis, cytotoxicity, carbonic anhydrase activity, and molecular modelling studies. Bioorganic Chemistry 110, pages 104778.
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Baijayantimala Swain, Abhay, Priti Singh, Andrea Angeli, Kamtam Aashritha, Narayana Nagesh, Claudiu T. Supuran & Mohammed Arifuddin. (2021) 3-Functionalised benzenesulphonamide based 1,3,4-oxadiazoles as selective carbonic anhydrase XIII inhibitors: Design, synthesis and biological evaluation. Bioorganic & Medicinal Chemistry Letters 37, pages 127856.
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Chandra Bhushan Mishra, Shikha Kumari, Andrea Angeli, Silvia Bua, Raj Kumar Mongre, Manisha Tiwari & Claudiu T. Supuran. (2021) Discovery of Potent Carbonic Anhydrase Inhibitors as Effective Anticonvulsant Agents: Drug Design, Synthesis, and In Vitro and In Vivo Investigations. Journal of Medicinal Chemistry 64:6, pages 3100-3114.
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Shubham Kumar, Sandeep Rulhania, Shalini Jaswal & Vikramdeep Monga. (2021) Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors. European Journal of Medicinal Chemistry 209, pages 112923.
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Abdeslem Bouzina, Malika Berredjem, Alessio Nocentini, Silvia Bua, Zouhair Bouaziz, Joachim Jose, Marc Le Borgne, Christelle Marminon, Paola Gratteri & Claudiu T. Supuran. (2021) Ninhydrins inhibit carbonic anhydrases directly binding to the metal ion. European Journal of Medicinal Chemistry 209, pages 112875.
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Simone Carradori & Claudiu T. Supuran. 2021. pH-Interfering Agents as Chemosensitizers in Cancer Therapy. pH-Interfering Agents as Chemosensitizers in Cancer Therapy
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Claudiu T. Supuran. 2021. The Carbonic Anhydrases: Current and Emerging Therapeutic Targets. The Carbonic Anhydrases: Current and Emerging Therapeutic Targets
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Claudiu T. Supuran. 2021. New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications. New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications
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Alessio Nocentini, Alane B. Vermelho & Claudiu T. Supuran. 2022. Antiprotozoal Drug Development and Delivery. Antiprotozoal Drug Development and Delivery
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Sinan Bilginer, Halise I. Gul, Baris Anil, Yeliz Demir & Ilhami Gulcin. (2020) Synthesis and in silico studies of triazene‐substituted sulfamerazine derivatives as acetylcholinesterase and carbonic anhydrases inhibitors. Archiv der Pharmazie 354:1, pages 2000243.
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Linda J. Urbański, Andrea Angeli, Vesa P. Hytönen, Anna Di Fiore, Seppo Parkkila, Giuseppina De Simone & Claudiu T. Supuran. (2020) Inhibition of the newly discovered β‑carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with inorganic anions and small molecules. Journal of Inorganic Biochemistry 213, pages 111274.
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Felipe Raposo Passos Mansoldo, Fabrizio Carta, Andrea Angeli, Veronica da Silva Cardoso, Claudiu T. Supuran & Alane Beatriz Vermelho. (2020) Chagas Disease: Perspectives on the Past and Present and Challenges in Drug Discovery. Molecules 25:22, pages 5483.
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Enrico Luchinat, Letizia Barbieri, Matteo Cremonini, Alessio Nocentini, Claudiu T. Supuran & Lucia Banci. (2020) Intracellular Binding/Unbinding Kinetics of Approved Drugs to Carbonic Anhydrase II Observed by in-Cell NMR. ACS Chemical Biology 15:10, pages 2792-2800.
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Andrea Angeli, Fabrizio Carta, Alessio Nocentini, Jean-Yves Winum, Raivis Zalubovskis, Atilla Akdemir, Valentina Onnis, Wagdy M. Eldehna, Clemente Capasso, Giuseppina De Simone, Simona Maria Monti, Simone Carradori, William A. Donald, Shoukat Dedhar & Claudiu T. Supuran. (2020) Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment. Metabolites 10:10, pages 412.
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Carlotta Zoppi, Alessio Nocentini, Claudiu T. Supuran, Alessandro Pratesi & Luigi Messori. (2020) Native mass spectrometry of human carbonic anhydrase I and its inhibitor complexes. JBIC Journal of Biological Inorganic Chemistry 25:7, pages 979-993.
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Mesut Işık, Süleyman Akocak, Nabih Lolak, Parham Taslimi, Cüneyt Türkeş, İlhami Gülçin, Mustafa Durgun & Şükrü Beydemir. (2020) Synthesis, characterization, biological evaluation, and in silico studies of novel 1,3‐diaryltriazene‐substituted sulfathiazole derivatives. Archiv der Pharmazie 353:9.
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Galina F. Makhaeva, Nadezhda V. Kovaleva, Natalia P. Boltneva, Sofya V. Lushchekina, Tatiana Yu. Astakhova, Elena V. Rudakova, Alexey N. Proshin, Igor V. Serkov, Eugene V. Radchenko, Vladimir A. Palyulin, Sergey O. Bachurin & Rudy J. Richardson. (2020) New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer’s Disease Treatment. Molecules 25:17, pages 3915.
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Aiga Grandāne, Alessio Nocentini, Ilona Domračeva, Raivis Žalubovskis & Claudiu T. Supuran. (2020) Development of oxathiino[6,5-b]pyridine 2,2-dioxide derivatives as selective inhibitors of tumor-related carbonic anhydrases IX and XII. European Journal of Medicinal Chemistry 200, pages 112300.
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Baijayantimala Swain, Andrea Angeli, Priti Singh, Claudiu T. Supuran & Mohammed Arifuddin. (2020) New coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation. Bioorganic & Medicinal Chemistry 28:15, pages 115586.
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Alessandro Bonardi, Alessio Nocentini, Silvia Bua, Jacob Combs, Carrie Lomelino, Jacob Andring, Laura Lucarini, Silvia Sgambellone, Emanuela Masini, Robert McKenna, Paola Gratteri & Claudiu T. Supuran. (2020) Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action. Journal of Medicinal Chemistry 63:13, pages 7422-7444.
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Agne Janoniene & Vilma Petrikaite. (2020) In Search of Advanced Tumor Diagnostics and Treatment: Achievements and Perspectives of Carbonic Anhydrase IX Targeted Delivery. Molecular Pharmaceutics 17:6, pages 1800-1815.
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Alessio Nocentini, Vincenzo Alterio, Silvia Bua, Laura Micheli, Davide Esposito, Martina Buonanno, Gianluca Bartolucci, Sameh M. Osman, Zeid A. ALOthman, Roberto Cirilli, Marco Pierini, Simona Maria Monti, Lorenzo Di Cesare Mannelli, Paola Gratteri, Carla Ghelardini, Giuseppina De Simone & Claudiu T. Supuran. (2020) Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy. Journal of Medicinal Chemistry 63:10, pages 5185-5200.
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Rita Meleddu, Simona Distinto, Filippo Cottiglia, Rossella Angius, Pierluigi Caboni, Andrea Angeli, Claudia Melis, Serenella Deplano, Stefano Alcaro, Francesco Ortuso, Claudiu T. Supuran & Elias Maccioni. (2020) New Dihydrothiazole Benzensulfonamides: Looking for Selectivity toward Carbonic Anhydrase Isoforms I, II, IX, and XII. ACS Medicinal Chemistry Letters 11:5, pages 852-856.
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Giuseppe La Regina, Michela Puxeddu, Marianna Nalli, Daniela Vullo, Paola Gratteri, Claudiu Trandafir Supuran, Alessio Nocentini & Romano Silvestri. (2019) Discovery of New 1,1′-Biphenyl-4-sulfonamides as Selective Subnanomolar Human Carbonic Anhydrase II Inhibitors. ACS Medicinal Chemistry Letters 11:5, pages 633-637.
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Priya Hargunani, Nikhil Tadge, Mariangela Ceruso, Janis Leitans, Andris Kazaks, Kaspars Tars, Paola Gratteri, Claudiu T. Supuran, Alessio Nocentini & Mrunmayee P. Toraskar. (2020) Aryl-4,5-dihydro-1H-pyrazole-1-carboxamide Derivatives Bearing a Sulfonamide Moiety Show Single-digit Nanomolar-to-Subnanomolar Inhibition Constants against the Tumor-associated Human Carbonic Anhydrases IX and XII. International Journal of Molecular Sciences 21:7, pages 2621.
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Majid Ali, Murat Bozdag, Umar Farooq, Andrea Angeli, Fabrizio Carta, Paola Berto, Giuseppe Zanotti & Claudiu T. Supuran. (2020) Benzylaminoethyureido-Tailed Benzenesulfonamides: Design, Synthesis, Kinetic and X-ray Investigations on Human Carbonic Anhydrases. International Journal of Molecular Sciences 21:7, pages 2560.
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Benas Balandis, Guostė Ivanauskaitė, Joana Smirnovienė, Kristina Kantminienė, Daumantas Matulis, Vytautas Mickevičius & Asta Zubrienė. (2020) Synthesis and structure–affinity relationship of chlorinated pyrrolidinone-bearing benzenesulfonamides as human carbonic anhydrase inhibitors. Bioorganic Chemistry 97, pages 103658.
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Kesari Lakshmi Manasa, Sravya Pujitha, Aaftaab Sethi, Mohammed Arifuddin, Mallika Alvala, Andrea Angeli & Claudiu T. Supuran. (2020) Synthesis and Biological Evaluation of Imidazo[2,1-b]Thiazole based Sulfonyl Piperazines as Novel Carbonic Anhydrase II Inhibitors. Metabolites 10:4, pages 136.
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Daniela Vullo, Ronny Lehneck, William A. Donald, Stefanie Pöggeler & Claudiu T. Supuran. (2020) Anion Inhibition Studies of the β-Class Carbonic Anhydrase CAS3 from the Filamentous Ascomycete Sordaria macrospora. Metabolites 10:3, pages 93.
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Andrea Petreni, Alessandro Bonardi, Carrie Lomelino, Sameh M. Osman, Zeid A. ALOthman, Wagdy M. Eldehna, Radwan El-Haggar, Robert McKenna, Alessio Nocentini & Claudiu T. Supuran. (2020) Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells. European Journal of Medicinal Chemistry 190, pages 112112.
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Daniela Vullo, Ronny Lehneck, William A. Donald, Stefanie Pöggeler & Claudiu T. Supuran. (2020) Sulfonamide Inhibition Studies of the β-Class Carbonic Anhydrase CAS3 from the Filamentous Ascomycete Sordaria macrospora. Molecules 25:5, pages 1036.
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Silvia Bua, Carrie Lomelino, Akilah B. Murray, Sameh M. Osman, Zeid A. ALOthman, Murat Bozdag, Hatem A. Abdel-Aziz, Wagdy M. Eldehna, Robert McKenna, Alessio Nocentini & Claudiu T. Supuran. (2019) “A Sweet Combination”: Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII. Journal of Medicinal Chemistry 63:1, pages 321-333.
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Alessio Nocentini, Davide Moi, Alessandro Deplano, Sameh M. Osman, Zeid A. AlOthman, Gianfranco Balboni, Claudiu T. Supuran & Valentina Onnis. (2020) Sulfonamide/sulfamate switch with a series of piperazinylureido derivatives: Synthesis, kinetic and in silico evaluation as carbonic anhydrase isoforms I, II, IV, and IX inhibitors. European Journal of Medicinal Chemistry 186, pages 111896.
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Baijayantimala Swain, Chander Singh Digwal, Andrea Angeli, Mallika Alvala, Priti Singh, Claudiu T. Supuran & Mohammed Arifuddin. (2019) Synthesis and exploration of 2-morpholino-4-phenylthiazol-5-yl acrylamide derivatives for their effects against carbonic anhydrase I, II, IX and XII isoforms as a non-sulfonamide class of inhibitors. Bioorganic & Medicinal Chemistry 27:21, pages 115090.
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Fabrizio Carta, Pascal Dumy, Claudiu T. Supuran & Jean-Yves Winum. (2019) Multivalent Carbonic Anhydrases Inhibitors. International Journal of Molecular Sciences 20:21, pages 5352.
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Kartsev, Geronikaki, Bua, Nocentini, Petrou, Lichitsky, Frasinyuk, Leitans, Kazaks, Tars & Supuran. (2019) Extending the Inhibition Profiles of Coumarin-Based Compounds Against Human Carbonic Anhydrases: Synthesis, Biological, and In Silico Evaluation. Molecules 24:19, pages 3580.
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Peng Lin, Junpeng Shi, Liyan Ming, Yangyang Sheng, Liang Song, Maochun Hong & Yun Zhang. (2021) An Intelligent Persistent Luminescence Nanoplatform with High-Efficiency O <sub>2</sub> Utilization for Continuous Hypoxic Tumors Treatment. SSRN Electronic Journal.
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