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Original Article

Multivariate models of health-related utility and the fear of hypoglycaemia in people with diabetes

, , , , &
Pages 1523-1534 | Accepted 12 Jun 2006, Published online: 28 Jun 2006

Keep up to date with the latest research on this topic with citation updates for this article.

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Taru Hallinen, Santtu Kivelä, Erkki Soini, Veli-Pekka Harjola & Mari Pesonen. (2023) Cost-Effectiveness of Empagliflozin in Combination with Standard Care versus Standard Care Only in the Treatment of Heart Failure Patients in Finland. ClinicoEconomics and Outcomes Research 15, pages 1-13.
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Jean-François Yale, Beatrice Osumili, Beth D. Mitchell, Barnaby Hunt, Gurjeev Sohi, Mark Jeddi, Donna Mojdami & William J. Valentine. (2022) Evaluation of the cost and medical resource use outcomes associated with nasal glucagon versus injectable glucagon for treatment of severe hypoglycemia in people with diabetes in Canada: a modeling analysis. Journal of Medical Economics 25:1, pages 238-248.
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Pieralessandro Lasalvia, Yaneth Gil-Rojas & Ángel García. (2022) Cost-effectiveness of dapagliflozin compared to DPP-4 inhibitors as combination therapy with metformin in the treatment of type 2 diabetes mellitus without established cardiovascular disease in Colombia. Expert Review of Pharmacoeconomics & Outcomes Research 22:6, pages 955-964.
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Yaneth Gil-Rojas, Pieralessandro Lasalvia & Ángel García. (2022) Cost-utility of dapagliflozin plus standard treatment compared to standard treatment for the management of heart failure with reduced ejection fraction in Colombia. Expert Review of Pharmacoeconomics & Outcomes Research 22:4, pages 655-663.
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Stephane Roze, John J Isitt, Jayne Smith-Palmer & Peter Lynch. (2021) Evaluation of the Long-Term Cost-Effectiveness of the Dexcom G6 Continuous Glucose Monitor versus Self-Monitoring of Blood Glucose in People with Type 1 Diabetes in Canada. ClinicoEconomics and Outcomes Research 13, pages 717-725.
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Stéphane Roze, Maria Ida Buompensiere, Zeynep Ozdemir, Simona de Portu & Ohad Cohen. (2021) Cost-effectiveness of a novel hybrid closed-loop system compared with continuous subcutaneous insulin infusion in people with type 1 diabetes in the UK. Journal of Medical Economics 24:1, pages 883-890.
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Johan Jendle, Åsa Ericsson, Bertil Ekman, Stefan Sjöberg, Jens Gundgaard, João da Rocha Fernandes, Ann-Charlotte Mårdby, Barnaby Hunt, Samuel J. P. Malkin & Maria Thunander. (2020) Real-world cost-effectiveness of insulin degludec in type 1 and type 2 diabetes mellitus from a Swedish 1-year and long-term perspective. Journal of Medical Economics 23:11, pages 1311-1320.
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Ching-Lun Chien, Yen-Chou Chen, Daniel C. Malone, Yueh-Lung Peng & Yu Ko. (2020) Cost-utility analysis of second-line anti-diabetic therapy in patients with type 2 diabetes mellitus inadequately controlled on metformin. Current Medical Research and Opinion 36:10, pages 1619-1626.
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Johannes Pöhlmann, Roberta Montagnoli, Giusi Lastoria, Witesh Parekh, Marie Markert & Barnaby Hunt. (2019) Value For Money In The Treatment Of Patients With Type 2 Diabetes Mellitus: Assessing The Long-Term Cost-Effectiveness Of IDegLira Versus iGlarLixi In Italy. ClinicoEconomics and Outcomes Research 11, pages 605-614.
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Stephané Roze, Jayne Smith-Palmer, Simona de Portu, Alexis Delbaere, Bonnie de Brouwer & Harold W de Valk. (2019) Cost-effectiveness of sensor-augmented insulin pump therapy vs continuous subcutaneous insulin infusion in patients with type 1 diabetes in the Netherlands. ClinicoEconomics and Outcomes Research 11, pages 73-82.
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Xiaoling Cai, Lizheng Shi, Wenjia Yang, Shuyan Gu, Yingyao Chen, Lin Nie & Linong Ji. (2019) Cost-effectiveness analysis of dapagliflozin treatment versus metformin treatment in Chinese population with type 2 diabetes. Journal of Medical Economics 22:4, pages 336-343.
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Richard F Pollock, Barrie Chubb, William J Valentine & Simon Heller. (2018) Evaluating the cost-effectiveness of insulin detemir versus neutral protamine Hagedorn insulin in patients with type 1 or type 2 diabetes in the UK using a short-term modeling approach. Diabetes, Metabolic Syndrome and Obesity 11, pages 217-226.
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Michael Dempsey, Michelle Mocarski, Jakob Langer & Barnaby Hunt. (2018) Long-term cost-effectiveness analysis shows that IDegLira is associated with improved outcomes and lower costs compared with insulin glargine U100 plus insulin aspart in the US. Journal of Medical Economics 21:11, pages 1110-1118.
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Edurne Lecumberri, Maite Ortega, Marta Iturregui, José Antonio Quesada, Clotilde Vázquez & Domingo Orozco. (2018) Quality-of-life and treatment satisfaction in actual clinical practice of patients with Type 1 diabetes mellitus (T1DM) and hypoglycemia treated with insulin degludec. Current Medical Research and Opinion 34:6, pages 1053-1059.
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Abhiroop Chakravarty, Mohini Rastogi, Praveen Dhankhar & Kelly F. Bell. (2018) Comparison of costs and outcomes of dapagliflozin with other glucose-lowering therapy classes added to metformin using a short-term cost-effectiveness model in the US setting. Journal of Medical Economics 21:5, pages 497-509.
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Hui Shao, Suodi Zhai, Dajin Zou, Mohammed Umer Mir, Nadine K. Zawadzki, Qian Shi, Shuqian Liu & Lizheng Shi. (2017) Cost-effectiveness analysis of dapagliflozin versus glimepiride as monotherapy in a Chinese population with type 2 diabetes mellitus. Current Medical Research and Opinion 33:2, pages 359-369.
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Jayne Smith-Palmer, Jay P Bae, Kristina S Boye, Kirsi Norrbacka, Barnaby Hunt & William J Valentine. (2016) Evaluating health-related quality of life in type 1 diabetes: a systematic literature review of utilities for adults with type 1 diabetes. ClinicoEconomics and Outcomes Research 8, pages 559-571.
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J. Gordon, P. McEwan, U. Sabale, B. Kartman & B. H. R. Wolffenbuttel. (2016) The cost-effectiveness of exenatide twice daily (BID) vs insulin lispro three times daily (TID) as add-on therapy to titrated insulin glargine in patients with type 2 diabetes. Journal of Medical Economics 19:12, pages 1167-1174.
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L. H. Chuang, B. G. Verheggen, M. Charokopou, D. Gibson, S. Grandy & B. Kartman. (2016) Cost-effectiveness analysis of exenatide once-weekly versus dulaglutide, liraglutide, and lixisenatide for the treatment of type 2 diabetes mellitus: an analysis from the UK NHS perspective. Journal of Medical Economics 19:12, pages 1127-1134.
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Ulrik Pedersen-Bjergaard, Peter Lommer Kristensen, Kirsten Nørgaard, Hans Perrild, Tonny Jensen, Birger Thorsteinsson, Annie Nikolajsen & Lise Tarnow. (2016) Short-term cost-effectiveness of insulin detemir and insulin aspart in people with type 1 diabetes who are prone to recurrent severe hypoglycemia. Current Medical Research and Opinion 32:10, pages 1719-1725.
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David Bruhn, Alan A. Martin, Ruben Tavares, Barnaby Hunt & Richard F. Pollock. (2016) Cost-utility of albiglutide versus insulin lispro, insulin glargine, and sitagliptin for the treatment of type 2 diabetes in the US. Journal of Medical Economics 19:7, pages 672-683.
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Stéphane Roze, Jayne Smith-Palmer, William J. Valentine, Mark Cook, Manisha Jethwa, Simona de Portu & John C. Pickup. (2016) Long-term health economic benefits of sensor-augmented pump therapy vs continuous subcutaneous insulin infusion alone in type 1 diabetes: a UK perspective. Journal of Medical Economics 19:3, pages 236-242.
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Frank Lavernia, Pamela Kushner, Dace Trence, Donna Rice, George Dailey & Louis Kuritzky. (2015) Recognizing and minimizing hypoglycemia: The need for individualized care. Postgraduate Medicine 127:8, pages 801-807.
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Shuyan Gu, Jing Deng, Lizheng Shi, Yiming Mu & Hengjin Dong. (2015) Cost-effectiveness of saxagliptin vs glimepiride as a second-line therapy added to metformin in Type 2 diabetes in China. Journal of Medical Economics 18:10, pages 808-820.
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Volker Foos, Nebibe Varol, Bradley H. Curtis, Kristina S. Boye, David Grant, James L. Palmer & Phil McEwan. (2015) Economic impact of severe and non-severe hypoglycemia in patients with Type 1 and Type 2 diabetes in the United States. Journal of Medical Economics 18:6, pages 420-432.
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M. Evans, M. Wolden, J. Gundgaard, B. Chubb & T. Christensen. (2015) Cost-effectiveness of insulin degludec compared with insulin glargine in a basal-bolus regimen in patients with type 1 diabetes mellitus in the UK. Journal of Medical Economics 18:1, pages 56-68.
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Daniel Viriato, Frederico Calado, Jean-Bernard Gruenberger, Siew Hwa Ong, Davide Carvalho, José Silva-Nunes, Sukhvinder Johal & Ricardo Viana. (2014) Cost-effectiveness of metformin plus vildagliptin compared with metformin plus sulphonylurea for the treatment of patients with type 2 diabetes mellitus: a Portuguese healthcare system perspective. Journal of Medical Economics 17:7, pages 499-507.
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Bo Ahrén. (2013) Avoiding hypoglycemia: a key to success for glucose-lowering therapy in type 2 diabetes. Vascular Health and Risk Management 9, pages 155-163.
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Stewart B Harris, Kamlesh Khunti, Mona Landin-Olsson, Claus B Galbo-Jørgensen, Mette Bøgelund, Barrie Chubb, Jens Gundgaard & Marc Evans. (2013) Descriptions of health states associated with increasing severity and frequency of hypoglycemia: a patient-level perspective. Patient Preference and Adherence 7, pages 925-936.
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Olena Mandrik, Johan L Severens, Olena Doroshenko, Vladymir Pan’kiv, Nonna Kravchun, Maryna Vlasenko, Mykola Hulchiy, Maryna Baljuk, Yuliia Komisarenko, Eugene Martsynik, Liubov Sokolova, Olga Zalis’ka & Boris Mankovsky. (2013) Impact of hypoglycemia on daily life of type 2 diabetes patients in Ukraine. Journal of Multidisciplinary Healthcare 6, pages 249-257.
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Tiago Fonseca, John Clegg, Giuseppe Caputo, Kirsi Norrbacka, Tatiana Dilla & Maria Alvarez. (2013) The cost-effectiveness of exenatide once weekly compared with exenatide twice daily and insulin glargine for the treatment of patients with type two diabetes and body mass index ≥30 kg/m2 in Spain. Journal of Medical Economics 16:7, pages 926-938.
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William D Willis, Jesús I Diago-Cabezudo, Anne Madec-Hily & Aftab Aslam. (2013) Medical resource use, disturbance of daily life and burden of hypoglycemia in insulin-treated patients with diabetes: results from a European online survey. Expert Review of Pharmacoeconomics & Outcomes Research 13:1, pages 123-130.
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Martin Pfohl, Peter K. Schädlich, Franz-Werner Dippel & Katharina C. Koltermann. (2012) Health economic evaluation of insulin glargine vs NPH insulin in intensified conventional therapy for type 1 diabetes in Germany. Journal of Medical Economics 15:sup2, pages 14-27.
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Yevgeniy Samyshkin, Anne-Laure Guillermin, Jennie H. Best, Steven C. Brunell & Adam Lloyd. (2012) Long-term cost-utility analysis of exenatide once weekly versus insulin glargine for the treatment of type 2 diabetes patients in the US. Journal of Medical Economics 15:sup2, pages 6-13.
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Johan Jendle, Sherry A Martin & Zvonko Milicevic. (2012) Insulin and GLP-1 analog combinations in type 2 diabetes mellitus: a critical review. Expert Opinion on Investigational Drugs 21:10, pages 1463-1474.
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Anne-Laure Guillermin, Adam Lloyd, Jennie H. Best, Mary Beth DeYoung, Yevgeniy Samyshkin & Julia Aledort Gaebler. (2012) Long-term cost-consequence analysis of exenatide once weekly vs sitagliptin or pioglitazone for the treatment of type 2 diabetes patients in the United States. Journal of Medical Economics 15:4, pages 654-663.
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Vasil Valov, James Palmer, Marcin Czech, Alexandra Savova & Guenka Petrova. (2012) Cost-Effectiveness of Biphasic Insulin Aspart 30 VS. Human Premix Insulin in Type 2 Diabetes from the Payer's Perspective in Bulgaria. Biotechnology & Biotechnological Equipment 26:2, pages 2937-2944.
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Nitil Kedia. (2011) Treatment of severe diabetic hypoglycemia with glucagon: an underutilized therapeutic approach. Diabetes, Metabolic Syndrome and Obesity 4, pages 337-346.
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Dong-Churl Suh & Mark Aagren. (2011) Cost–effectiveness of insulin detemir: a systematic review. Expert Review of Pharmacoeconomics & Outcomes Research 11:6, pages 641-655.
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Carrie Fidler, Torsten Elmelund Christensen & Samantha Gillard. (2011) Hypoglycemia: An overview of fear of hypoglycemia, quality-of-life, and impact on costs. Journal of Medical Economics 14:5, pages 646-655.
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James L. Palmer, Martin S. Knudsen, Mark Aagren & Trine L. Thomsen. (2010) Cost-effectiveness of switching to biphasic insulin aspart from human premix insulin in a US setting. Journal of Medical Economics 13:2, pages 212-220.
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Mette Hammer, Morten Lammert, Susana Monereo Mejías, Werner Kern & Brian M. Frier. (2009) Costs of managing severe hypoglycaemia in three European countries. Journal of Medical Economics 12:4, pages 281-290.
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Craig J. Currie, Chris D. Poole & Natalie L. Papo. (2009) An overview and commentary on retrospective, continuous glucose monitoring for the optimisation of care for people with diabetes. Current Medical Research and Opinion 25:10, pages 2389-2400.
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Sandra L. Tunis, Michael E. Minshall, Christopher Conner, John I. McCormick, Jovana Kapor, Jean-François Yale & Danielle Groleau. (2009) Cost-effectiveness of insulin detemir compared to NPH insulin for type 1 and type 2 diabetes mellitus in the Canadian payer setting: modeling analysis. Current Medical Research and Opinion 25:5, pages 1273-1284.
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James L. Palmer, Gordon Goodall, Steffen Nielsen, Robert W. Kotchie, William J. Valentine, Andrew J. Palmer & Stéphane Roze. (2008) Cost-effectiveness of insulin aspart versus human soluble insulin in type 2 diabetes in four European countries: subgroup analyses from the PREDICTIVE study. Current Medical Research and Opinion 24:5, pages 1417-1428.
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Henry Howard Goldstein. (2008) Pen Devices to Improve Patient Adherence With Insulin Therapy in Type 2 Diabetes. Postgraduate Medicine 120:3, pages 172-179.
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Mohammed Ali, Jeremy White, Chen-Hui Lee, James L Palmer, Jayne Smith-Palmer, Walid Fakhoury & William J Valentine. (2008) Therapy conversion to biphasic insulin aspart 30 improves long-term outcomes and reduces the costs of type 2 diabetes in Saudi Arabia. Journal of Medical Economics 11:4, pages 651-670.
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P Banck-Petersen, T Larsen, U Pedersen-Bjergaard, L Bie-Olsen, T Høi-Hansen & B Thorsteinsson. (2007) Concerns about hypoglycaemia and late complications in patients with insulin-treated diabetes. European Diabetes Nursing 4:3, pages 113-118.
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Phil McEwan, Chris D. Poole, Tony Tetlow, Paul Holmes & Craig J. Currie. (2007) Evaluation of the cost-effectiveness of insulin glargine versus NPH insulin for the treatment of type 2 diabetes in the UK. Current Medical Research and Opinion 23:sup1, pages S21-S31.
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Phil McEwan, Chris D. Poole, Tony Tetlow, Paul Holmes & Craig J. Currie. (2007) Evaluation of the cost-effectiveness of insulin glargine versus NPH insulin for the treatment of type 1 diabetes in the UK. Current Medical Research and Opinion 23:sup1, pages S7-S19.
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Simon Dixon & John R. Peters. (2007) Evaluating the ‘real’ cost-effectiveness of health technology: reconciling the public interest with patients’ interests. Current Medical Research and Opinion 23:sup1, pages S1-S6.
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