Cancer Biology & Therapy, Volume 13, Issue 11 (2012)

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Cancer Biology & Therapy, Volume 13, Issue 11 (2012)

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Clinical Study

Article
pEGFR-Tyr 845 expression as prognostic factors in oral squamous cell carcinoma
A tissue-microarray study with clinic-pathological correlations
Gabriella Aquino, Giuseppe Pannone, Angela Santoro, Giuseppina Liguori, Renato Franco, Rosario Serpico, Gianluca Florio, Alfredo De Rosa, Marilena Mattoni, Valentina Cozza, Gerardo Botti, Simona Losito, Francesco Longo, Stefania Staibano, Giovanni Cuda, Lorenzo Lo Muzio, Carolina Sbordone, Pantaleo Bufo, Anna Grimaldi, Michele Caraglia & Marina Di Domenico
Pages: 967-977
Published online: 24 Jul 2012
AbstractforpEGFR-Tyr 845 expression as prognostic factors in oral squamous cell carcinoma | Full Text | References | PDF (2 MB)
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Review

Review Article
Autophagic action of new targeting agents in head and neck oncology
Hidemi Rikiishi
Pages: 978-991
Published online: 24 Jul 2012
AbstractforAutophagic action of new targeting agents in head and neck oncology | Full Text | References | PDF (867.3 KB)
  • 956 Views
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Review Article
Regulation of oncogene-induced cell cycle exit and senescence by chromatin modifiers
Gregory David
Pages: 992-1000
Published online: 24 Jul 2012
AbstractforRegulation of oncogene-induced cell cycle exit and senescence by chromatin modifiers | PDF (1.1 MB)
  • 406 Views
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Review Article
Medical strategies for treatment of castration resistant prostate cancer (CRPC) docetaxel resistant
Amelia Altavilla, Roberto Iacovelli, Giuseppe Procopio, Daniele Alesini, Emanuela Risi, Giuseppe Maria Campennì, Antonella Palazzo & Enrico Cortesi
Pages: 1001-1008
Published online: 24 Jul 2012
AbstractforMedical strategies for treatment of castration resistant prostate cancer (CRPC) docetaxel resistant | Full Text | References | PDF (884 KB)
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Research Paper

Article
Perifosine enhances mTORC1-targeted cancer therapy by activation of GSK3β in NSCLC cells
Zhuo Ma, Lingjun Zhu, Xuan Luo, Sulan Zhai, Ping Li & Xuerong Wang
Pages: 1009-1017
Published online: 24 Jul 2012
AbstractforPerifosine enhances mTORC1-targeted cancer therapy by activation of GSK3β in NSCLC cells | Full Text | References | PDF (1.6 MB)
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Article
Interferon-gamma enhances radiation-induced cell death via downregulation of Chk1
Kwang Seok Kim, Kyu Jin Choi & Sangwoo Bae
Pages: 1018-1025
Published online: 24 Jul 2012
AbstractforInterferon-gamma enhances radiation-induced cell death via downregulation of Chk1 | Full Text | References | PDF (1.1 MB)
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Article
Inhibition of p38-MAPK alters SRC coactivation and estrogen receptor phosphorylation
James W. Antoon, Melyssa R. Bratton, Lori M. Guillot, Scott Wadsworth, Virgilio A. Salvo & Matthew E. Burow
Pages: 1026-1033
Published online: 24 Jul 2012
AbstractforInhibition of p38-MAPK alters SRC coactivation and estrogen receptor phosphorylation | Full Text | References | PDF (1.4 MB)
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Article
Aurora kinase inhibitor VE 465 synergistically enhances cytotoxicity of carboplatin in ovarian cancer cells through induction of apoptosis and downregulation of histone 3
Siqing Fu, Yanfang li, Jie Huang, Tao Liu, Zhen Hong, Aiping Chen, Robert C. Bast, John J. Kavanagh, David M. Gershenson, Anil K. Sood & Wei Hu
Pages: 1034-1041
Published online: 16 Aug 2012
AbstractforAurora kinase inhibitor VE 465 synergistically enhances cytotoxicity of carboplatin in ovarian cancer cells through induction of apoptosis and downregulation of histone 3 | Full Text | References | PDF (3.5 MB)
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Article
Cullin-3 protein expression levels correlate with breast cancer progression
Kelly K. Haagenson, Larry Tait, Juan Wang, Malathy P. Shekhar, Lisa Polin, Wei Chen & Gen Sheng Wu
Pages: 1042-1046
Published online: 24 Jul 2012
AbstractforCullin-3 protein expression levels correlate with breast cancer progression | Full Text | References | PDF (1.8 MB)
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Article
Differential regulation of p21waf1 protein half-life by DNA damage and Nutlin-3 in p53 wild-type tumors and its therapeutic implications
Li-Ju Chang & Alan Eastman
Pages: 1047-1057
Published online: 24 Jul 2012
AbstractforDifferential regulation of p21waf1 protein half-life by DNA damage and Nutlin-3 in p53 wild-type tumors and its therapeutic implications | Full Text | References | PDF (1.8 MB) | Supplemental
  • 792 Views
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Article
Antagonism between curcumin and the topoisomerase II inhibitor etoposide
A study of DNA damage, cell cycle regulation and death pathways
Ekram M. Saleh, Raafat A El-awady, Nadia A. Eissa & Wael M. Abdel-Rahman
Pages: 1058-1071
Published online: 16 Aug 2012
AbstractforAntagonism between curcumin and the topoisomerase II inhibitor etoposide | Full Text | References | PDF (3.1 MB)
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Article
The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy
Remko Prevo, Emmanouil Fokas, Philip M. Reaper, Peter A. Charlton, John R. Pollard, W. Gillies McKenna, Ruth J. Muschel & Thomas B. Brunner
Pages: 1072-1081
Published online: 24 Jul 2012
AbstractforThe novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy | Full Text | References | PDF (1.7 MB) | Supplemental
  • 3436 Views
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Article
Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells
Baiqing Tang, Joseph R. Testa & Warren D. Kruger
Pages: 1082-1090
Published online: 24 Jul 2012
AbstractforIncreasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells | PDF (1.4 MB) | Supplemental
  • 516 Views
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Article
E2F-1 lacking the transcriptional activity domain induces autophagy
Aracely Garcia-Garcia, Humberto Rodriguez-Rocha, Michael T. Tseng, Roberto Montes de Oca-Luna, H. Sam Zhou, Kelly M. McMasters & Jorge G. Gomez-Gutierrez
Pages: 1091-1101
Published online: 24 Jul 2012
AbstractforE2F-1 lacking the transcriptional activity domain induces autophagy | Full Text | References | PDF (1.8 MB)
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Article
Dual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1α expression by blocking protein translation and increases cell death under hypoxia
Jayashree Karar, George J. Cerniglia, Tullia Lindsten, Constantinos Koumenis & Amit Maity
Pages: 1102-1111
Published online: 16 Aug 2012
AbstractforDual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1α expression by blocking protein translation and increases cell death under hypoxia | Full Text | References | PDF (1.6 MB) | Supplemental
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Article
Gadd45a inhibits cell migration and invasion by altering the global RNA expression
Zhanhai Shan, Guiyuan Li, Qimin Zhan & Dan Li
Pages: 1112-1122
Published online: 24 Jul 2012
AbstractforGadd45a inhibits cell migration and invasion by altering the global RNA expression | Full Text | References | PDF (8.3 MB) | Supplemental
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Article
Protein expression changes during human triple negative breast cancer cell line progression to lymph node metastasis in a xenografted model in nude mice
María Paula Roberti, Juan Martín Arriaga, Michele Bianchini, Héctor Ramiro Quintá, Alicia Inés Bravo, Estrella Mariel Levy, José Mordoh & María Marcela Barrio
Pages: 1123-1140
Published online: 24 Jul 2012
AbstractforProtein expression changes during human triple negative breast cancer cell line progression to lymph node metastasis in a xenografted model in nude mice | PDF (2.6 MB) | Supplemental
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