Cancer Biology & Therapy, Volume 22, Issue 10-12 (2021)

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Cancer Biology & Therapy, Volume 22, Issue 10-12 (2021)

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Review

The role of the ubiquitin-proteasome pathway in skin cancer development: 26S proteasome-activated NF-κB signal transduction
Ouadie Mohamed El Yaagoubi, Larbi Oularbi, Abdelhakim Bouyahya, Hamid Samaki, Said El Antri & Souad Aboudkhil
Pages: 479-492
Published online: 29 Sep 2021
AbstractforThe role of the ubiquitin-proteasome pathway in skin cancer development: 26S proteasome-activated NF-κB signal transduction | Full Text | References | PDF (1.2 MB) | EPUB
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Oxygen and metabolic reprogramming in the tumor microenvironment influences metastasis homing
Vinod S. Bisht, Kuldeep Giri, Deepak Kumar & Kiran Ambatipudi
Pages: 493-512
Published online: 25 Oct 2021
AbstractforOxygen and metabolic reprogramming in the tumor microenvironment influences metastasis homing | Full Text | References | PDF (1.3 MB) | EPUB
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Interleukin-2, Ipilimumab, and Anti-PD-1: clinical management and the evolving role of immunotherapy for the treatment of patients with metastatic melanoma
Tasha Hughes, Matthew Klairmont, William H. Sharfman & Howard L. Kaufman
Pages: 513-526
Published online: 19 Nov 2021
AbstractforInterleukin-2, Ipilimumab, and Anti-PD-1: clinical management and the evolving role of immunotherapy for the treatment of patients with metastatic melanoma | Full Text | References | PDF (1.1 MB) | EPUB
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Journal Club

Article
Dead or alive? Pitfall of survival analysis with TCGA datasets
Masashi Idogawa, Masayo Koizumi, Tomomi Hirano, Shoichiro Tange, Hiroshi Nakase & Takashi Tokino
Pages: 527-528
Published online: 16 Sep 2021
AbstractforDead or alive? Pitfall of survival analysis with TCGA datasets | Full Text | References | PDF (200.8 KB) | EPUB | Supplemental
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Article
Ibrutinib’s off-target mechanism: cause for dose optimization
Sara M. Zimmerman, Cody J. Peer & William D. Figg
Pages: 529-531
Published online: 10 Oct 2021
AbstractforIbrutinib’s off-target mechanism: cause for dose optimization | Full Text | References | PDF (220.5 KB) | EPUB
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Bedside-to-Bench Report

Article
Multimodality therapy in metastatic pancreas cancer with a BRCA mutation and durable long-term outcome: biology, intervention, or both?
Thomas L. Sutton, Aaron Grossberg, Frederick Ey, Eileen M. O’Reilly & Brett C. Sheppard
Pages: 532-536
Published online: 25 Oct 2021
AbstractforMultimodality therapy in metastatic pancreas cancer with a BRCA mutation and durable long-term outcome: biology, intervention, or both? | Full Text | References | PDF (914.5 KB) | EPUB
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Article
Successful PD-1 inhibitor treatment in a patient with refractory transformed follicular lymphoma who failed to respond to CAR-T cell therapy: a case report and literature review
Weicheng Zheng, Qingfeng Xue, Xueping Sha, Yao Wang, Yuan Wang, Juan Liu, Yaping Zhang & Wenyu Shi
Pages: 537-543
Published online: 27 Sep 2021
AbstractforSuccessful PD-1 inhibitor treatment in a patient with refractory transformed follicular lymphoma who failed to respond to CAR-T cell therapy: a case report and literature review | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Research Paper

Article
Phase I double-blind, placebo-controlled trial of dolcanatide (SP-333) 27 mg to explore colorectal bioactivity in healthy volunteers
David S. Weinberg, Nathan R. Foster, Gary Della’Zanna, Ryan P. McMurray, Walter K. Kraft, Angela Pallotto, David M. Kastenberg, Leo C. Katz, Christopher H. Henry, Stephanie M. Moleski, Paul J. Limburg & Scott A. Waldman
Pages: 544-553
Published online: 10 Oct 2021
AbstractforPhase I double-blind, placebo-controlled trial of dolcanatide (SP-333) 27 mg to explore colorectal bioactivity in healthy volunteers | Full Text | References | PDF (518.3 KB) | EPUB
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Article
Antitumorigenic effect of combination treatment with ONC201 and TRAIL in endometrial cancer in vitro and in vivo
Jocelyn E. Ray, Marie D. Ralff, Aakash Jhaveri, Lanlan Zhou, David T. Dicker, Eric A. Ross & Wafik S. El-Deiry
Pages: 554-563
Published online: 25 Oct 2021
AbstractforAntitumorigenic effect of combination treatment with ONC201 and TRAIL in endometrial cancer in vitro and in vivo | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
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Article
Plasma KRAS mutations predict the early recurrence after surgical resection of pancreatic cancer
Soichiro Ako, Hironari Kato, Kazuhiro Nouso, Hideaki Kinugasa, Hiroyuki Terasawa, Hiroshi Matushita, Saimon Takada, Yosuke Saragai, Sho Mizukawa, Shinichiro Muro, Daisuke Uchida, Takeshi Tomoda, Kazuyuki Matsumoto, Shigeru Horiguchi, Daisuke Nobuoka, Ryuichi Yoshida, Yuzo Umeda, Takahito Yagi & Hiroyuki Okada
Pages: 564-570
Published online: 10 Oct 2021
AbstractforPlasma KRAS mutations predict the early recurrence after surgical resection of pancreatic cancer | Full Text | References | PDF (664.3 KB) | EPUB
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Article
MiR-133b suppresses the proliferation, migration and invasion of lung adenocarcinoma cells by targeting SKA3
Ming Zhang, Xiang Lan & Yong Chen
Pages: 571-578
Published online: 28 Oct 2021
AbstractforMiR-133b suppresses the proliferation, migration and invasion of lung adenocarcinoma cells by targeting SKA3 | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
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Article
Biguanide drugs enhance cytotoxic effects of cisplatin by depleting aspartate and NAD+ in sensitive cancer cells
Ellen Tully, Santosh Bharti, Juhyung Woo, Zaver Bhujwalla & Edward Gabrielson
Pages: 579-586
Published online: 31 Oct 2021
AbstractforBiguanide drugs enhance cytotoxic effects of cisplatin by depleting aspartate and NAD+ in sensitive cancer cells | Full Text | References | PDF (3 MB) | EPUB
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Research paper

Article
NSUN6, an RNA methyltransferase of 5-mC controls glioblastoma response to temozolomide (TMZ) via NELFB and RPS6KB2 interaction
Chidiebere U Awah, Jan Winter, Claudiane M Mazdoom & Olorunseun O. Ogunwobi
Pages: 587-597
Published online: 27 Oct 2021
AbstractforNSUN6, an RNA methyltransferase of 5-mC controls glioblastoma response to temozolomide (TMZ) via NELFB and RPS6KB2 interaction | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Article
Requirement for containing etoposide in the initial treatment of lymphoma associated hemophagocytic lymphohistiocytosis
Yue Song, Jingshi Wang, Yini Wang, Lin Wu & Zhao Wang
Pages: 598-606
Published online: 01 Nov 2021
AbstractforRequirement for containing etoposide in the initial treatment of lymphoma associated hemophagocytic lymphohistiocytosis | Full Text | References | PDF (541.3 KB) | EPUB
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Research Paper

Article
Combination of ONC201 and TLY012 induces selective, synergistic apoptosis in vitro and significantly delays PDAC xenograft growth in vivo
Aakash V. Jhaveri, Lanlan Zhou, Marie D. Ralff, Young S. Lee, Arunasalam Navaraj, Benedito A. Carneiro, Howard Safran, Varun V. Prabhu, Eric A. Ross, Seulki Lee & Wafik S. El-Deiry
Pages: 607-618
Published online: 02 Dec 2021
AbstractforCombination of ONC201 and TLY012 induces selective, synergistic apoptosis in vitro and significantly delays PDAC xenograft growth in vivo | Full Text | References | PDF (3 MB) | EPUB | Supplemental
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Article
Targeted FGFR/VEGFR/PDGFR inhibition with dovitinib enhances the effects of nab-paclitaxel in preclinical gastric cancer models
Kate Crawford, Erin Bontrager, Margaret A. Schwarz, Apurva Chaturvedi, Daniel D. Lee, Hassan Md Sazzad, Urs von Holzen, Changhua Zhang, Roderich E. Schwarz & Niranjan Awasthi
Pages: 619-629
Published online: 09 Dec 2021
AbstractforTargeted FGFR/VEGFR/PDGFR inhibition with dovitinib enhances the effects of nab-paclitaxel in preclinical gastric cancer models | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Article
STAT1 mediated long non-coding RNA LINC00504 influences radio-sensitivity of breast cancer via binding to TAF15 and stabilizing CPEB2 expression
Jinchun Feng, Yan Li, Liping Zhu, Qian Zhao, Dan Li, Yuxiang Li & Tao Wu
Pages: 630-639
Published online: 15 Dec 2021
AbstractforSTAT1 mediated long non-coding RNA LINC00504 influences radio-sensitivity of breast cancer via binding to TAF15 and stabilizing CPEB2 expression | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
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Article
RETRACTED ARTICLE: DGUOK-AS1 promotes the proliferation cervical cancer through regulating miR-653-5p/EMSY
Anqi Yan, Guanhao Chen & Jichan Nie
Pages: v-xiii
Published online: 13 Jul 2020
AbstractforRETRACTED ARTICLE: DGUOK-AS1 promotes the proliferation cervical cancer through regulating miR-653-5p/EMSY | PDF (17.1 MB)
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Correction

Correction
Correction
Page: 640
Published online: 10 Oct 2021
CitationforCorrection | Full Text | PDF (150.4 KB) | EPUB
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