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Editorial

Carbonic anhydrase inhibitors: an editorial

Pages 677-679 | Published online: 06 Mar 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (26)

Viviana De Luca, Andrea Petreni, Vincenzo Carginale, Andrea Scaloni, Claudiu T. Supuran & Clemente Capasso. (2021) Effect of amino acids and amines on the activity of the recombinant ι-carbonic anhydrase from the Gram-negative bacterium Burkholderia territorii. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1000-1006.
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Morteza Abdoli, Andrea Angeli, Murat Bozdag, Fabrizio Carta, Ali Kakanejadifard, Hamid Saeidian & Claudiu T. Supuran. (2017) Synthesis and carbonic anhydrase I, II, VII, and IX inhibition studies with a series of benzo[d]thiazole-5- and 6-sulfonamides. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 1071-1078.
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Alessio Nocentini, Daniela Vullo, Sonia Del Prete, Sameh M. Osman, Fatmah A.S. Alasmary, Zeid AlOthman, Clemente Capasso, Fabrizio Carta, Paola Gratteri & Claudiu T. Supuran. (2017) Inhibition of the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa with monothiocarbamates. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 1064-1070.
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Erol Licsandru, Muhammet Tanc, Istvan Kocsis, Mihail Barboiu & Claudiu T. Supuran. (2017) A class of carbonic anhydrase I – selective activators. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 37-46.
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Fadime Özbey, Parham Taslimi, İlhami Gülçin, Ahmet Maraş, Süleyman Göksu & Claudiu T. Supuran. (2016) Synthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup2, pages 79-85.
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Burhanettin Turan, Kivilcim Şendil, Emin Şengül, Mehmet Serdar Gültekin, Parham Taslimi, İlhami Gulçin & Claudiu T. Supuran. (2016) The synthesis of some β-lactams and investigation of their metal-chelating activity, carbonic anhydrase and acetylcholinesterase inhibition profiles. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup1, pages 79-88.
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Halise Inci Gul, Mehtap Tugrak, Hiroshi Sakagami, Parham Taslimi, Ilhami Gulcin & Claudiu T. Supuran. (2016) Synthesis and bioactivity studies on new 4-(3-(4-Substitutedphenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl) benzenesulfonamides. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1619-1624.
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F. Zehra Küçükbay, Nesrin Buğday, Hasan Küçükbay, Muhammet Tanc & Claudiu T. Supuran. (2016) Synthesis, characterization and carbonic anhydrase inhibitory activity of novel benzothiazole derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1221-1225.
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F. Zehra Küçükbay, Hasan Küçükbay, Muhammet Tanc & Claudiu T. Supuran. (2016) Synthesis and carbonic anhydrase inhibitory properties of amino acid – coumarin/quinolinone conjugates incorporating glycine, alanine and phenylalanine moieties. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1198-1202.
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Sonia Del Prete, Viviana De Luca, Daniela Vullo, Sameh M. Osman, Zeid AlOthman, Vincenzo Carginale, Claudiu T. Supuran & Clemente Capasso. (2016) A new procedure for the cloning, expression and purification of the β-carbonic anhydrase from the pathogenic yeast Malassezia globosa, an anti-dandruff drug target. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1156-1161.
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Ayşenur Eminoğlu, Daniela Vullo, Aycan Aşık, Dilşat Nigar Çolak, Claudiu T. Supuran, Sabriye Çanakçı & Ali Osman Beldüz. (2016) Cloning, expression and biochemical characterization of a β-carbonic anhydrase from the soil bacterium Enterobacter sp. B13. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1111-1118.
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Belma Zengin Kurt, Fatih Sönmez, Çiğdem Bilen, Adem Ergun, Nahit Gençer, Oktay Arslan & Mustafa Kucukislamoglu. (2016) Synthesis, antioxidant and carbonic anhydrase I and II inhibitory activities of novel sulphonamide-substituted coumarylthiazole derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 991-998.
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Koray Oktay, Leyla Polat Köse, Kıvılcım Şendil, Mehmet Serdar Gültekin, İlhami Gülçin & Claudiu T. Supuran. (2016) The synthesis of (Z)-4-oxo-4-(arylamino)but-2-enoic acids derivatives and determination of their inhibition properties against human carbonic anhydrase I and II isoenzymes. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 939-945.
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Claudiu T. Supuran & Clemente Capasso. (2016) New light on bacterial carbonic anhydrases phylogeny based on the analysis of signal peptide sequences. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1254-1260.
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Viviana De Luca, Sonia Del Prete, Daniela Vullo, Vincenzo Carginale, Pietro Di Fonzo, Sameh M Osman, Zeid AlOthman, Claudiu T Supuran & Clemente Capasso. (2016) Expression and characterization of a recombinant psychrophilic γ-carbonic anhydrase (NcoCA) identified in the genome of the Antarctic cyanobacteria belonging to the genus Nostoc. Journal of Enzyme Inhibition and Medicinal Chemistry 31:5, pages 810-817.
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Claudiu T. Supuran. (2016) How many carbonic anhydrase inhibition mechanisms exist?. Journal of Enzyme Inhibition and Medicinal Chemistry 31:3, pages 345-360.
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Murat Bozdag, Fabrizio Carta, Daniela Vullo, Semra Isik, Zeid AlOthman, Sameh M. Osman, Andrea Scozzafava & Claudiu T. Supuran. (2016) Dithiocarbamates with potent inhibitory activity against the Saccharomyces cerevisiae β-carbonic anhydrase. Journal of Enzyme Inhibition and Medicinal Chemistry 31:1, pages 132-136.
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Sonia Del Prete, Viviana De Luca, Claudiu T. Supuran & Clemente Capasso. (2015) Protonography, a technique applicable for the analysis of η-carbonic anhydrase activity. Journal of Enzyme Inhibition and Medicinal Chemistry 30:6, pages 920-924.
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Joanna Ombouma, Daniela Vullo, Stephan Köhler, Pascal Dumy, Claudiu T. Supuran & Jean-Yves Winum. (2015) N-glycosyl-N-hydroxysulfamides as potent inhibitors of Brucella suis carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry 30:6, pages 1010-1012.
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Namrata Singasane, Prashant S. Kharkar, Mariangela Ceruso, Claudiu T. Supuran & Mrunmayee P. Toraskar. (2015) Inhibition of carbonic anhydrase isoforms I, II, IX and XII with Schiff’s bases incorporating iminoureido moieties. Journal of Enzyme Inhibition and Medicinal Chemistry 30:6, pages 901-907.
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Viviana De Luca, Sonia Del Prete, Vincenzo Carginale, Daniela Vullo, Claudiu T. Supuran & Clemente Capasso. (2015) A failed tentative to design a super carbonic anhydrase having the biochemical properties of the most thermostable CA (SspCA) and the fastest (SazCA) enzymes. Journal of Enzyme Inhibition and Medicinal Chemistry 30:6, pages 989-994.
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Daniela Vullo, Semra Isik, Murat Bozdag, Fabrizio Carta & Claudiu T. Supuran. (2015) 7-Amino-3,4-dihydro-1H-quinolin-2-one, a compound similar to the substituted coumarins, inhibits α-carbonic anhydrases without hydrolysis of the lactam ring. Journal of Enzyme Inhibition and Medicinal Chemistry 30:5, pages 773-777.
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Claudiu T Supuran & Clemente Capasso. (2015) The η-class carbonic anhydrases as drug targets for antimalarial agents. Expert Opinion on Therapeutic Targets 19:4, pages 551-563.
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Daniela Vullo, Mladen Milos, Borivoj Galic, Andrea Scozzafava & Claudiu T. Supuran. (2015) Dipotassium-trioxohydroxytetrafluorotriborate, K2[B3O3F4OH], is a potent inhibitor of human carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry 30:2, pages 341-344.
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Clemente Capasso & Claudiu T. Supuran. (2015) An overview of the alpha-, beta- and gamma-carbonic anhydrases from Bacteria: can bacterial carbonic anhydrases shed new light on evolution of bacteria?. Journal of Enzyme Inhibition and Medicinal Chemistry 30:2, pages 325-332.
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Baijayantimala Swain, Kamtam Aashritha, Priti Singh, Andrea Angeli, Abhay Kothari, Dilep K. Sigalapalli, Venkata M. Yaddanapudi, Claudiu T. Supuran & Mohammed Arifuddin. (2021) Design and synthesis of benzenesulfonamide‐linked imidazo[2,1‐ b ][1,3,4]thiadiazole derivatives as carbonic anhydrase I and II inhibitors . Archiv der Pharmazie 354:7, pages 2100028.
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Zuhal Alım, Zeynep Köksal & Muhammet Karaman. (2020) Evaluation of some thiophene-based sulfonamides as potent inhibitors of carbonic anhydrase I and II isoenzymes isolated from human erythrocytes by kinetic and molecular modelling studies. Pharmacological Reports 72:6, pages 1738-1748.
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Azizah M. Malebari, Tarek S. Ibrahim, Ibrahim M. Salem, Ismail Salama, Ahdab N. Khayyat, Samia M. Mostafa, Osama I. El-Sabbagh & Khaled M. Darwish. (2020) The Anticancer Activity for the Bumetanide-Based Analogs via Targeting the Tumor-Associated Membrane-Bound Human Carbonic Anhydrase-IX Enzyme. Pharmaceuticals 13:9, pages 252.
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Clemente Capasso & Mihail Barboiu. 2019. Carbonic Anhydrases. Carbonic Anhydrases 495 514 .
Claudiu T. Supuran & Andrea Scozzafava. 2019. Carbonic Anhydrases. Carbonic Anhydrases 245 255 .
Halise Inci Gul, Cem Yamali, Merve Bulbuller, Petek Ballar Kirmizibayrak, Mustafa Gul, Andrea Angeli, Silvia Bua & Claudiu T. Supuran. (2018) Anticancer effects of new dibenzenesulfonamides by inducing apoptosis and autophagy pathways and their carbonic anhydrase inhibitory effects on hCA I, hCA II, hCA IX, hCA XII isoenzymes. Bioorganic Chemistry 78, pages 290-297.
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Sonia Del Prete, Silvia Bua, Didier Zoccola, Fatmah Alasmary, Zeid AlOthman, Linah Alqahtani, Nathalie Techer, Claudiu Supuran, Sylvie Tambutté & Clemente Capasso. (2018) Comparison of the Anion Inhibition Profiles of the α-CA Isoforms (SpiCA1, SpiCA2 and SpiCA3) from the Scleractinian Coral Stylophora pistillata. International Journal of Molecular Sciences 19:7, pages 2128.
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Halise Inci Gul, Cem Yamali, Hiroshi Sakagami, Andrea Angeli, Janis Leitans, Andris Kazaks, Kaspars Tars, Dilan Ozmen Ozgun & Claudiu T. Supuran. (2018) New anticancer drug candidates sulfonamides as selective hCA IX or hCA XII inhibitors. Bioorganic Chemistry 77, pages 411-419.
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Marta Ferraroni, Benedetta Cornelio, Janos Sapi, Claudiu T. Supuran & Andrea Scozzafava. (2018) Sulfonamide carbonic anhydrase inhibitors: Zinc coordination and tail effects influence inhibitory efficacy and selectivity for different isoforms. Inorganica Chimica Acta 470, pages 128-132.
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Justina Kazokaitė, Ashok Aspatwar, Seppo Parkkila & Daumantas Matulis. (2017) An update on anticancer drug development and delivery targeting carbonic anhydrase IX. PeerJ 5, pages e4068.
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Mina Ghiasi & Mina Seifi. (2017) Thermodynamic study on the mechanism of carbonic anhydrase XII inhibition with glycosyl coumarin as non-zinc mediated inhibitors: A quantum mechanical investigation. Computational and Theoretical Chemistry 1118, pages 16-25.
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Andrea Angeli, Alaa A.-M. Abdel-Aziz, Alessio Nocentini, Adel S. El-Azab, Paola Gratteri & Claudiu T. Supuran. (2017) Synthesis and carbonic anhydrase inhibition of polycyclic imides incorporating N-benzenesulfonamide moieties. Bioorganic & Medicinal Chemistry 25:20, pages 5373-5379.
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Michel Petitjean. (2017) A Fast Algorithm to Compute Conical Pockets in Proteins. Application to the Structural Characterization of γ -Carbonic Anhydrases . Molecular Informatics 36:10, pages 1600155.
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Jekaterīna Ivanova, Fabrizio Carta, Daniela Vullo, Janis Leitans, Andris Kazaks, Kaspars Tars, Raivis Žalubovskis & Claudiu T. Supuran. (2017) N -Substituted and ring opened saccharin derivatives selectively inhibit transmembrane, tumor-associated carbonic anhydrases IX and XII. Bioorganic & Medicinal Chemistry 25:13, pages 3583-3589.
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Suleyman Akocak, Nabih Lolak, Alessio Nocentini, Gulcin Karakoc, Anzel Tufan & Claudiu T. Supuran. (2017) Synthesis and biological evaluation of novel aromatic and heterocyclic bis-sulfonamide Schiff bases as carbonic anhydrase I, II, VII and IX inhibitors. Bioorganic & Medicinal Chemistry 25:12, pages 3093-3097.
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Çetin Bayrak, Parham Taslimi, İlhami Gülçin & Abdullah Menzek. (2017) The first synthesis of 4-phenylbutenone derivative bromophenols including natural products and their inhibition profiles for carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase enzymes. Bioorganic Chemistry 72, pages 359-366.
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Aydın Aktaş, Parham Taslimi, İlhami Gülçin & Yetkin Gök. (2017) Novel NHC Precursors: Synthesis, Characterization, and Carbonic Anhydrase and Acetylcholinesterase Inhibitory Properties. Archiv der Pharmazie 350:6, pages e201700045.
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Fabrizio Carta, Daniela Vullo, Sameh M. Osman, Zeid AlOthman & Claudiu T. Supuran. (2017) Synthesis and carbonic anhydrase inhibition of a series of SLC-0111 analogs. Bioorganic & Medicinal Chemistry 25:9, pages 2569-2576.
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Yeganeh Entezari Heravi, Silvia Bua, Alessio Nocentini, Sonia Del Prete, Ali Akbar Saboury, Hassan Sereshti, Clemente Capasso, Paola Gratteri & Claudiu T. Supuran. (2017) Inhibition of Malassezia globosa carbonic anhydrase with phenols. Bioorganic & Medicinal Chemistry 25:9, pages 2577-2582.
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Tiphaine Rogez-Florent, Catherine Foulon, Anne-Sophie Drucbert, Nadège Schifano, Perrine Six, Stéphanie Devassine, Patrick Depreux, Pierre-Marie Danzé, Laurence Goossens, Cécile Danel & Jean-François Goossens. (2017) Chiral separation of new sulfonamide derivatives and evaluation of their enantioselective affinity for human carbonic anhydrase II by microscale thermophoresis and surface plasmon resonance. Journal of Pharmaceutical and Biomedical Analysis 137, pages 113-122.
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Menshawy A. Mohamed, Alaa A.-M. Abdel-Aziz, Helmy M. Sakr, Adel S. El-Azab, Silvia Bua & Claudiu T. Supuran. (2017) Synthesis and human/bacterial carbonic anhydrase inhibition with a series of sulfonamides incorporating phthalimido moieties. Bioorganic & Medicinal Chemistry 25:8, pages 2524-2529.
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Andrea Angeli, Damiano Tanini, Caterina Viglianisi, Lucia Panzella, Antonella Capperucci, Stefano Menichetti & Claudiu T. Supuran. (2017) Evaluation of selenide, diselenide and selenoheterocycle derivatives as carbonic anhydrase I, II, IV, VII and IX inhibitors. Bioorganic & Medicinal Chemistry 25:8, pages 2518-2523.
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Mustafa Ceylan, Umit M. Kocyigit, Necibe Canan Usta, Belma Gürbüzlü, Yusuf Temel, Saleh H. Alwasel & İlhami Gülçin. (2017) Synthesis, carbonic anhydrase I and II isoenzymes inhibition properties, and antibacterial activities of novel tetralone-based 1,4-benzothiazepine derivatives. Journal of Biochemical and Molecular Toxicology 31:4, pages e21872.
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Sonia Del Prete, Daniela Vullo, Pietro Di Fonzo, Sameh M. Osman, Zeid AlOthman, William A. Donald, Claudiu T. Supuran & Clemente Capasso. (2017) Sulfonamide inhibition profile of the γ-carbonic anhydrase identified in the genome of the pathogenic bacterium Burkholderia pseudomallei the etiological agent responsible of melioidosis. Bioorganic & Medicinal Chemistry Letters 27:3, pages 490-495.
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Rajiv Kumar, Silvia Bua, Sita Ram, Sonia Del Prete, Clemente Capasso, Claudiu T. Supuran & Pawan K. Sharma. (2017) Benzenesulfonamide bearing imidazothiadiazole and thiazolotriazole scaffolds as potent tumor associated human carbonic anhydrase IX and XII inhibitors. Bioorganic & Medicinal Chemistry 25:3, pages 1286-1293.
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Daniela Vullo, Sonia Del Prete, Alessio Nocentini, Sameh M. Osman, Zeid AlOthman, Clemente Capasso, Murat Bozdag, Fabrizio Carta, Paola Gratteri & Claudiu T. Supuran. (2017) Dithiocarbamates effectively inhibit the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa. Bioorganic & Medicinal Chemistry 25:3, pages 1260-1265.
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Belma Z. Kurt, Fatih Sonmez, Basak Gokce, Adem Ergun, Nahit Gencer, Taki Demir, Oktay Arslan & Mustafa Kucukislamoglu. (2016) In vitro inhibition effects on erythrocyte carbonic anhydrase I and II and structure-activity relationships of cumarylthiazole derivatives. Russian Journal of Bioorganic Chemistry 42:5, pages 506-511.
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Sonia Del Prete, Daniela Vullo, Viviana De Luca, Vincenzo Carginale, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran & Clemente Capasso. (2016) Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum. Bioorganic & Medicinal Chemistry Letters 26:17, pages 4184-4190.
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Tekin Artunç, Yasin Çetinkaya, Hülya Göçer, İlhami Gülçin, Abdullah Menzek, Ertan Şahin & Claudiu T. Supuran. (2016) Synthesis of 4-[2-(3,4-dimethoxybenzyl)cyclopentyl]-1,2-dimethoxybenzene Derivatives and Evaluations of Their Carbonic Anhydrase Isoenzymes Inhibitory Effects. Chemical Biology & Drug Design 87:4, pages 594-607.
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Ayşenur Eminoğlu, Daniela Vullo, Aycan Aşık, Dilşat Nigar Çolak, Sabriye Çanakçı, Ali Osman Beldüz & Claudiu T. Supuran. (2016) Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13. Bioorganic & Medicinal Chemistry Letters 26:7, pages 1821-1826.
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Hanshu Zhao, Karen E. Carney, Lindsay Falgoust, Jullie W. Pan, Dandan Sun & Zhongling Zhang. (2016) Emerging roles of Na+/H+ exchangers in epilepsy and developmental brain disorders. Progress in Neurobiology 138-140, pages 19-35.
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Daniela Vullo, Sonia Del Prete, Clemente Capasso & Claudiu T. Supuran. (2016) Carbonic anhydrase activators: Activation of the β-carbonic anhydrase from Malassezia globosa with amines and amino acids. Bioorganic & Medicinal Chemistry Letters 26:5, pages 1381-1385.
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Daniela Vullo, Sonia Del Prete, Viviana De Luca, Vincenzo Carginale, Marta Ferraroni, Nurcan Dedeoglu, Sameh M. Osman, Zeid AlOthman, Clemente Capasso & Claudiu T. Supuran. (2016) Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae. Bioorganic & Medicinal Chemistry Letters 26:5, pages 1406-1410.
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Sonia Del Prete, Daniela Vullo, Viviana De Luca, Vincenzo Carginale, Marta Ferraroni, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran & Clemente Capasso. (2016) Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae. Bioorganic & Medicinal Chemistry 24:5, pages 1115-1120.
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Mustafa Durgun, Hasan Turkmen, Mariangela Ceruso & Claudiu T. Supuran. (2016) Synthesis of 4-sulfamoylphenyl-benzylamine derivatives with inhibitory activity against human carbonic anhydrase isoforms I, II, IX and XII. Bioorganic & Medicinal Chemistry 24:5, pages 982-988.
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B. Richichi, V. Baldoneschi, S. Burgalassi, M. Fragai, D. Vullo, A. Akdemir, E. Dragoni, A. Louka, M. Mamusa, D. Monti, D. Berti, E. Novellino, G. De Rosa, C. T. Supuran & C. Nativi. (2016) A Divalent PAMAM-Based Matrix Metalloproteinase/Carbonic Anhydrase Inhibitor for the Treatment of Dry Eye Syndrome. Chemistry - A European Journal 22:5, pages 1714-1721.
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Daniela Vullo, Avni Bhatt, Brian P. Mahon, Robert McKenna & Claudiu T. Supuran. (2016) Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA. Bioorganic & Medicinal Chemistry Letters 26:2, pages 401-405.
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Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Rezk R. Ayyad, Mariangela Ceruso & Claudiu T. Supuran. (2016) Inhibition of carbonic anhydrase isoforms I, II, IV, VII and XII with carboxylates and sulfonamides incorporating phthalimide/phthalic anhydride scaffolds. Bioorganic & Medicinal Chemistry 24:1, pages 20-25.
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Claudiu T. Supuran & Clemente Capasso. 2017. Zinc Enzyme Inhibitors. Zinc Enzyme Inhibitors 111 133 .
Alessandra Cincinelli, Tania Martellini, Daniela Vullo & Claudiu T. Supuran. (2015) Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus. Bioorganic & Medicinal Chemistry Letters 25:23, pages 5485-5489.
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Sonia Del Prete, Daniela Vullo, Sameh M. Osman, Zeid AlOthman, Clemente Capasso & Claudiu T. Supuran. (2015) Anion inhibition studies of the dandruff-producing fungus Malassezia globosa β-carbonic anhydrase MgCA. Bioorganic & Medicinal Chemistry Letters 25:22, pages 5194-5198.
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Viviana De Luca, Sonia Del Prete, Vincenzo Carginale, Daniela Vullo, Claudiu T. Supuran & Clemente Capasso. (2015) Cloning, characterization and anion inhibition studies of a γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune. Bioorganic & Medicinal Chemistry Letters 25:21, pages 4970-4975.
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Alfonso Maresca, Gulay Akyuz, Sameh M. Osman, Zeid AlOthman & Claudiu T. Supuran. (2015) Inhibition of mammalian carbonic anhydrase isoforms I–XIV with a series of phenolic acid esters. Bioorganic & Medicinal Chemistry 23:22, pages 7181-7188.
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Fabrizio Carta, Sameh M. Osman, Daniela Vullo, Zeid AlOthman, Sonia Del Prete, Clemente Capasso & Claudiu T. Supuran. (2015) Poly(amidoamine) dendrimers show carbonic anhydrase inhibitory activity against α-, β-, γ- and η-class enzymes. Bioorganic & Medicinal Chemistry 23:21, pages 6794-6798.
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Cenzo Congiu, Valentina Onnis, Alessandro Deplano, Gianfranco Balboni, Nurcan Dedeoglu & Claudiu T. Supuran. (2015) Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase I, II, IX and XII inhibitory activity. Bioorganic & Medicinal Chemistry Letters 25:18, pages 3850-3853.
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Cenzo Congiu, Valentina Onnis, Alessandro Deplano, Gianfranco Balboni, Mariangela Ceruso & Claudiu T. Supuran. (2015) Synthesis and carbonic anhydrase I, II, IX and XII inhibitory activity of sulfamates incorporating piperazinyl-ureido moieties. Bioorganic & Medicinal Chemistry 23:17, pages 5619-5625.
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Mariangela Ceruso, Fabrizio Carta, Sameh M. Osman, Zeid Alothman, Simona Maria Monti & Claudiu T. Supuran. (2015) Inhibition studies of bacterial, fungal and protozoan β-class carbonic anhydrases with Schiff bases incorporating sulfonamide moieties. Bioorganic & Medicinal Chemistry 23:15, pages 4181-4187.
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Viviana De Luca, Daniela Vullo, Sonia Del Prete, Vincenzo Carginale, Andrea Scozzafava, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran & Clemente Capasso. (2015) Cloning, characterization and anion inhibition studies of a new γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis. Bioorganic & Medicinal Chemistry 23:15, pages 4405-4409.
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Diaa A. Ibrahim, Deena S. Lasheen, Maysoun Y. Zaky, Amany W. Ibrahim, Daniela Vullo, Mariangela Ceruso, Claudiu T. Supuran & Dalal A. Abou El Ella. (2015) Design and synthesis of benzothiazole-6-sulfonamides acting as highly potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII. Bioorganic & Medicinal Chemistry 23:15, pages 4989-4999.
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Nadia Touisni, Nasreddine Kanfar, Sébastien Ulrich, Pascal Dumy, Claudiu T. Supuran, Ahmad Mehdi & Jean‐Yves Winum. (2015) Fluorescent Silica Nanoparticles with Multivalent Inhibitory Effects towards Carbonic Anhydrases. Chemistry – A European Journal 21:29, pages 10306-10309.
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Nurcan Dedeoglu, Viviana De Luca, Semra Isik, Hatice Yildirim, Feray Kockar, Clemente Capasso & Claudiu T. Supuran. (2015) Cloning, characterization and anion inhibition study of a β-class carbonic anhydrase from the caries producing pathogen Streptococcus mutans. Bioorganic & Medicinal Chemistry 23:13, pages 2995-3001.
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Nurcan Dedeoglu, Viviana DeLuca, Semra Isik, Hatice Yildirim, Feray Kockar, Clemente Capasso & Claudiu T. Supuran. (2015) Sulfonamide inhibition study of the β-class carbonic anhydrase from the caries producing pathogen Streptococcus mutans. Bioorganic & Medicinal Chemistry Letters 25:11, pages 2291-2297.
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Mustafa Durgun, Hasan Turkmen, Mariangela Ceruso & Claudiu T. Supuran. (2015) Synthesis of Schiff base derivatives of 4-(2-aminoethyl)-benzenesulfonamide with inhibitory activity against carbonic anhydrase isoforms I, II, IX and XII. Bioorganic & Medicinal Chemistry Letters 25:11, pages 2377-2381.
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Fabrizio Carta, Sameh M. Osman, Daniela Vullo, Antonella Gullotto, Jean-Yves Winum, Zeid AlOthman, Emanuela Masini & Claudiu T. Supuran. (2015) Poly(amidoamine) Dendrimers with Carbonic Anhydrase Inhibitory Activity and Antiglaucoma Action. Journal of Medicinal Chemistry 58:9, pages 4039-4045.
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Ashwani Mittal & Rajesh Dabur. (2015) Detection of New Human Metabolic Urinary Markers in Chronic Alcoholism and Their Reversal by Aqueous Extract of Tinospora cordifolia Stem. Alcohol and Alcoholism 50:3, pages 271-281.
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Murat Bozdag, Fabrizio Carta, Daniela Vullo, Atilla Akdemir, Semra Isik, Cecilia Lanzi, Andrea Scozzafava, Emanuela Masini & Claudiu T. Supuran. (2015) Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action. Bioorganic & Medicinal Chemistry 23:10, pages 2368-2376.
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Giuseppina De Simone, Anna Di Fiore, Clemente Capasso & Claudiu T. Supuran. (2015) The zinc coordination pattern in the η-carbonic anhydrase from Plasmodium falciparum is different from all other carbonic anhydrase genetic families. Bioorganic & Medicinal Chemistry Letters 25:7, pages 1385-1389.
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Daniela Vullo, Viviana De Luca, Sonia Del Prete, Vincenzo Carginale, Andrea Scozzafava, Clemente Capasso & Claudiu T. Supuran. (2015) Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune. Bioorganic & Medicinal Chemistry 23:8, pages 1728-1734.
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Aiga Grandane, Muhammet Tanc, Raivis Žalubovskis & Claudiu T. Supuran. (2015) Synthesis of 6-aryl-substituted sulfocoumarins and investigation of their carbonic anhydrase inhibitory action. Bioorganic & Medicinal Chemistry 23:7, pages 1430-1436.
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Melissa A. Pinard, Brian Mahon & Robert McKenna. (2015) Probing the Surface of Human Carbonic Anhydrase for Clues towards the Design of Isoform Specific Inhibitors. BioMed Research International 2015, pages 1-15.
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Fabrizio Carta, Sameh M. Osman, Daniela Vullo, Zeid AlOthman & Claudiu T. Supuran. (2015) Dendrimers incorporating benzenesulfonamide moieties strongly inhibit carbonic anhydrase isoforms I–XIV. Organic & Biomolecular Chemistry 13:23, pages 6453-6457.
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Fulvio Ratto, Ewa Witort, Francesca Tatini, Sonia Centi, Lorenza Lazzeri, Fabrizio Carta, Matteo Lulli, Daniela Vullo, Franco Fusi, Claudiu T. Supuran, Andrea Scozzafava, Sergio Capaccioli & Roberto Pini. (2015) Plasmonic Particles that Hit Hypoxic Cells. Advanced Functional Materials 25:2, pages 316-323.
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Mariangela Ceruso, Sabrina Antel, Daniela Vullo, Andrea Scozzafava & Claudiu T. Supuran. (2014) Inhibition studies of new ureido-substituted sulfonamides incorporating a GABA moiety against human carbonic anhydrase isoforms I–XIV. Bioorganic & Medicinal Chemistry 22:24, pages 6768-6775.
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Busra Sarikaya, Mariangela Ceruso, Fabrizio Carta & Claudiu T. Supuran. (2014) Inhibition of carbonic anhydrase isoforms I, II, IX and XII with novel Schiff bases: Identification of selective inhibitors for the tumor-associated isoforms over the cytosolic ones. Bioorganic & Medicinal Chemistry 22:21, pages 5883-5890.
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Ahmed M. Alafeefy, Mariangela Ceruso, Abdul-Malek S. Al-Tamimi, Sonia Del Prete, Clemente Capasso & Claudiu T. Supuran. (2014) Quinazoline–sulfonamides with potent inhibitory activity against the α-carbonic anhydrase from Vibrio cholerae. Bioorganic & Medicinal Chemistry 22:19, pages 5133-5140.
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Sonia Del Prete, Daniela Vullo, Gillian M. Fisher, Katherine T. Andrews, Sally-Ann Poulsen, Clemente Capasso & Claudiu T. Supuran. (2014) Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum —The η-carbonic anhydrases. Bioorganic & Medicinal Chemistry Letters 24:18, pages 4389-4396.
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Daniela Vullo, Sonia Del Prete, Sameh M. Osman, Andrea Scozzafava, Zeid Alothman, Claudiu T. Supuran & Clemente Capasso. (2014) Anion inhibition study of the β-class carbonic anhydrase (PgiCAb) from the oral pathogen Porphyromonas gingivalis. Bioorganic & Medicinal Chemistry Letters 24:18, pages 4402-4406.
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Mariangela Ceruso, Sonia Del Prete, Zeid AlOthman, Sameh M. Osman, Andrea Scozzafava, Clemente Capasso & Claudiu T. Supuran. (2014) Synthesis of sulfonamides with effective inhibitory action against Porphyromonas gingivalis γ-carbonic anhydrase. Bioorganic & Medicinal Chemistry Letters 24:16, pages 4006-4010.
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Melissa D’Ascenzio, Simone Carradori, Daniela Secci, Daniela Vullo, Mariangela Ceruso, Atilla Akdemir & Claudiu T. Supuran. (2014) Selective inhibition of human carbonic anhydrases by novel amide derivatives of probenecid: Synthesis, biological evaluation and molecular modelling studies. Bioorganic & Medicinal Chemistry 22:15, pages 3982-3988.
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Gihane Nasr, Alina Cristian, Mihail Barboiu, Daniella Vullo, Jean-Yves Winum & Claudiu T. Supuran. (2014) Carbonic anhydrase inhibitors. Inhibition of human cytosolic isoforms I and II with (reduced) Schiff’s bases incorporating sulfonamide, carboxylate and carboxymethyl moieties. Bioorganic & Medicinal Chemistry 22:10, pages 2867-2874.
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Mariusz Mojzych, Anna Bielawska, Krzysztof Bielawski, Mariangela Ceruso & Claudiu T. Supuran. (2014) Pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors with antitumor activity. Bioorganic & Medicinal Chemistry 22:9, pages 2643-2647.
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Cenzo Congiu, Valentina Onnis, Gianfranco Balboni & Claudiu T. Supuran. (2014) Synthesis and carbonic anhydrase I, II, IX and XII inhibition studies of 4-N,N-disubstituted sulfanilamides incorporating 4,4,4-trifluoro-3-oxo-but-1-enyl, phenacylthiourea and imidazol-2(3H)-one/thione moieties. Bioorganic & Medicinal Chemistry Letters 24:7, pages 1776-1779.
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Aiga Grandane, Muhammet Tanc, Raivis Zalubovskis & Claudiu T. Supuran. (2014) 6-Triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrases IX and XII. Bioorganic & Medicinal Chemistry Letters 24:5, pages 1256-1260.
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Amrita K. Saluja, Meena Tiwari, Daniela Vullo & Claudiu T. Supuran. (2014) Substituted benzene sulfonamides incorporating 1,3,5-triazinyl moieties potently inhibit human carbonic anhydrases II, IX and XII. Bioorganic & Medicinal Chemistry Letters 24:5, pages 1310-1314.
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Melissa D’Ascenzio, Simone Carradori, Celeste De Monte, Daniela Secci, Mariangela Ceruso & Claudiu T. Supuran. (2014) Design, synthesis and evaluation of N-substituted saccharin derivatives as selective inhibitors of tumor-associated carbonic anhydrase XII. Bioorganic & Medicinal Chemistry 22:6, pages 1821-1831.
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Aiga Grandane, Muhammet Tanc, Raivis Zalubovskis & Claudiu T. Supuran. (2014) Synthesis of 6-tetrazolyl-substituted sulfocoumarins acting as highly potent and selective inhibitors of the tumor-associated carbonic anhydrase isoforms IX and XII. Bioorganic & Medicinal Chemistry 22:5, pages 1522-1528.
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Daniela Vullo, Sonia Del Prete, Sameh M. Osman, Viviana De Luca, Andrea Scozzafava, Zeid AlOthman, Claudiu T. Supuran & Clemente Capasso. (2014) Sulfonamide inhibition studies of the γ-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis. Bioorganic & Medicinal Chemistry Letters 24:1, pages 240-244.
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Daniela Vullo, Sonia Del Prete, Sameh M. Osman, Viviana De Luca, Andrea Scozzafava, Zeid AlOthman, Claudiu T. Supuran & Clemente Capasso. (2014) Sulfonamide inhibition studies of the δ-carbonic anhydrase from the diatom Thalassiosira weissflogii. Bioorganic & Medicinal Chemistry Letters 24:1, pages 275-279.
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Ahmed M. Alafeefy, Hatem A. Abdel-Aziz, Daniela Vullo, Abdul-Malek S. Al-Tamimi, Nabila A. Al-Jaber, Clemente Capasso & Claudiu T. Supuran. (2014) Inhibition of carbonic anhydrases from the extremophilic bacteria Sulfurihydrogenibium yellostonense (SspCA) and S. azorense (SazCA) with a new series of sulfonamides incorporating aroylhydrazone-, [1,2,4]triazolo[3,4-b][1,3,4]thiadiazinyl- or 2-(cyanophenylmethylene)-1,3,4-thiadiazol-3(2H)-yl moieties. Bioorganic & Medicinal Chemistry 22:1, pages 141-147.
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Murat Bozdag, Marta Ferraroni, Elisa Nuti, Daniela Vullo, Armando Rossello, Fabrizio Carta, Andrea Scozzafava & Claudiu T. Supuran. (2014) Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: Solution and X-ray crystallographic studies. Bioorganic & Medicinal Chemistry 22:1, pages 334-340.
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Simone Carradori, Celeste De Monte, Melissa D’Ascenzio, Daniela Secci, Gulsah Celik, Mariangela Ceruso, Daniela Vullo, Andrea Scozzafava & Claudiu T. Supuran. (2013) Salen and tetrahydrosalen derivatives act as effective inhibitors of the tumor-associated carbonic anhydrase XII—A new scaffold for designing isoform-selective inhibitors. Bioorganic & Medicinal Chemistry Letters 23:24, pages 6759-6763.
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Mariangela Ceruso, Daniela Vullo, Andrea Scozzafava & Claudiu T. Supuran. (2013) Inhibition of human carbonic anhydrase isoforms I–XIV with sulfonamides incorporating fluorine and 1,3,5-triazine moieties. Bioorganic & Medicinal Chemistry 21:22, pages 6929-6936.
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Özlen Güzel-Akdemir, Shyamasri Biswas, Katherine Lastra, Robert McKenna & Claudiu T. Supuran. (2013) Structural study of the location of the phenyl tail of benzene sulfonamides and the effect on human carbonic anhydrase inhibition. Bioorganic & Medicinal Chemistry 21:21, pages 6674-6680.
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Shyamasri Biswas, Robert McKenna & Claudiu T. Supuran. (2013) Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII. Bioorganic & Medicinal Chemistry Letters 23:20, pages 5646-5649.
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Ramazan Ulus, İbrahim Yeşildağ, Muhammet Tanç, Metin Bülbül, Muharrem Kaya & Claudiu T. Supuran. (2013) Synthesis of novel acridine and bis acridine sulfonamides with effective inhibitory activity against the cytosolic carbonic anhydrase isoforms II and VII. Bioorganic & Medicinal Chemistry 21:18, pages 5799-5805.
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Janis Leitans, Agnese Sprudza, Muhammet Tanc, Igor Vozny, Raivis Zalubovskis, Kaspars Tars & Claudiu T. Supuran. (2013) 5-Substituted-(1,2,3-triazol-4-yl)thiophene-2-sulfonamides strongly inhibit human carbonic anhydrases I, II, IX and XII: Solution and X-ray crystallographic studies. Bioorganic & Medicinal Chemistry 21:17, pages 5130-5138.
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Christopher Boone, Andrew Habibzadegan, Sonika Gill & Robert McKenna. (2013) Carbonic Anhydrases and Their Biotechnological Applications. Biomolecules 3:4, pages 553-562.
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Özlen Güzel-Akdemir, Atilla Akdemir, Peiwen Pan, Alane B. Vermelho, Seppo Parkkila, Andrea Scozzafava, Clemente Capasso & Claudiu T. Supuran. (2013) A Class of Sulfonamides with Strong Inhibitory Action against the α-Carbonic Anhydrase from Trypanosoma cruzi . Journal of Medicinal Chemistry 56:14, pages 5773-5781.
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