Nucleosides, Nucleotides & Nucleic Acids, Volume 29, Issue 4-6 (2010)

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Nucleosides, Nucleotides & Nucleic Acids, Volume 29, Issue 4-6 (2010)

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Original Articles

Article
Purine and Pyrimidine Metabolism in the Fist Decade of the 21st Century—Highlights and Perspectives
Staffan Eriksson & Godefridus J. Peters
Pages: i-xi
Published online: 11 Jun 2010
First Page PreviewforPurine and Pyrimidine Metabolism in the Fist Decade of the 21st Century—Highlights and Perspectives | Full Text | References | PDF (68.7 KB)
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Article
In Memoriam: Dr. Hermione Anne Simmonds
(December 6, 1927 –April 2, 2010)
David Perrett
Pages: xii-xvii
Published online: 11 Jun 2010
First Page PreviewforIn Memoriam: Dr. Hermione Anne Simmonds | Full Text | References | PDF (75.7 KB)
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Article
Novel Strategies in the Thiopurine Treatment of Inflammatory Bowel Disease
S. Almer
Pages: 267-277
Published online: 11 Jun 2010
AbstractforNovel Strategies in the Thiopurine Treatment of Inflammatory Bowel Disease | Full Text | References | PDF (359.9 KB)
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Article
How Should Thiopurine Treatment be Monitored?— Methodological Aspects
S. Vikingsson, B. Carlsson, S. Almer & C. Peterson
Pages: 278-283
Published online: 11 Jun 2010
AbstractforHow Should Thiopurine Treatment be Monitored?— Methodological Aspects | Full Text | References | PDF (57.1 KB)
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Article
Limited Intra-Individual Variability in Hypoxanthine-Guanine Phosphoribosyl Transferase, Thiopurine S-Methyl Transferase, and Xanthine Oxidase Activity in Inflammatory Bowel Disease Patients During 6-Thioguanine Therapy
D. P. van Asseldonk, N. K. H. de Boer, K. Smid, C. J. Mulder, A. A. van Bodegraven & G. J. Peters
Pages: 284-290
Published online: 11 Jun 2010
AbstractforLimited Intra-Individual Variability in Hypoxanthine-Guanine Phosphoribosyl Transferase, Thiopurine S-Methyl Transferase, and Xanthine Oxidase Activity in Inflammatory Bowel Disease Patients During 6-Thioguanine Therapy | Full Text | References | PDF (147.8 KB)
  • 116 Views
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Article
Molecular Analysis of Two Enzyme Genes, HPRT1 and PRPS1, Causing X-Linked Inborn Errors of Purine Metabolism
Y. Yamada, K. Yamada, N. Nomura, A. Yamano, R. Kimura, S. Tomida, M. Naiki & N. Wakamatsu
Pages: 291-294
Published online: 11 Jun 2010
AbstractforMolecular Analysis of Two Enzyme Genes, HPRT1 and PRPS1, Causing X-Linked Inborn Errors of Purine Metabolism | Full Text | References | PDF (91.6 KB)
  • 169 Views
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Article
Partial HPRT Deficiency Phenotype and Incomplete Splicing Mutation
R. J. Torres, M. G. Garcia & J. G. Puig
Pages: 295-300
Published online: 11 Jun 2010
AbstractforPartial HPRT Deficiency Phenotype and Incomplete Splicing Mutation | Full Text | References | PDF (113 KB)
  • 104 Views
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Article
Methylation Status of HPRT1 Promoter in HPRT Deficiency with Normal Coding Region
M. G. Garcia, R. J. Torres & J. G. Puig
Pages: 301-305
Published online: 11 Jun 2010
AbstractforMethylation Status of HPRT1 Promoter in HPRT Deficiency with Normal Coding Region | Full Text | References | PDF (128.9 KB)
  • 147 Views
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Article
Delayed Treatment Effects of Xanthine Oxidase Inhibition on Systolic Overload-Induced Left Ventricular Hypertrophy and Dysfunction
X. Xu, L. Zhao, X. Hu, P. Zhang, J. Wessale, R. Bache & Y. Chen
Pages: 306-313
Published online: 11 Jun 2010
AbstractforDelayed Treatment Effects of Xanthine Oxidase Inhibition on Systolic Overload-Induced Left Ventricular Hypertrophy and Dysfunction | Full Text | References | PDF (346.9 KB)
  • 594 Views
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Open Access
Article
Establishment and Analysis of SLC22A12 (URAT1) Knockout Mouse
M. Hosoyamada, Y. Takiue, H. Morisaki, J. Cheng, M. Ikawa, M. Okabe, T. Morisaki, K. Ichida, T. Hosoya & T. Shibasaki
Pages: 314-320
Published online: 11 Jun 2010
AbstractforEstablishment and Analysis of SLC22A12 (URAT1) Knockout Mouse | Full Text | References | PDF (178.6 KB)
  • 311 Views
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Article
Effects of Three Strong Statins (Atorvastatin, Pitavastatin, and Rosuvastatin) on Serum Uric Acid Levels in Dyslipidemic Patients
N. Ogata, S. Fujimori, Y. Oka & K. Kaneko
Pages: 321-324
Published online: 11 Jun 2010
AbstractforEffects of Three Strong Statins (Atorvastatin, Pitavastatin, and Rosuvastatin) on Serum Uric Acid Levels in Dyslipidemic Patients | Full Text | References | PDF (70.8 KB)
  • 303 Views
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Article
Metabolic Syndrome Characteristics in Gout Patients
J. M. Fraile, R. J. Torres, Mendieta E. de Miguel, P. Martínez, K. J. Lundelin, J. J. Vázquez & J. G. Puig
Pages: 325-329
Published online: 11 Jun 2010
AbstractforMetabolic Syndrome Characteristics in Gout Patients | Full Text | References | PDF (121 KB)
  • 176 Views
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Article
Uric Acid Metabolism in Patients with Primary Gout and the Metabolic Syndrome
J. M. Fraile, J. G. Puig, Rosa J. Torres, Eugenio de Miguel, Pedro Martínez & J. J. Vázquez
Pages: 330-334
Published online: 11 Jun 2010
AbstractforUric Acid Metabolism in Patients with Primary Gout and the Metabolic Syndrome | Full Text | References | PDF (89.6 KB)
  • 162 Views
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Article
Role of Nucleoside Transporters in Nucleoside-Derived Drug Sensitivity
M. Molina-Arcas & M. Pastor-Anglada
Pages: 335-346
Published online: 11 Jun 2010
AbstractforRole of Nucleoside Transporters in Nucleoside-Derived Drug Sensitivity | Full Text | References | PDF (116 KB)
  • 3032 Views
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Article
Thymidine Kinase 1 Deficient Cells Show Increased Survival Rate After UV-Induced DNA Damage
T. Skovgaard, L. J. Rasmussen & B. Munch-Petersen
Pages: 347-351
Published online: 11 Jun 2010
AbstractforThymidine Kinase 1 Deficient Cells Show Increased Survival Rate After UV-Induced DNA Damage | Full Text | References | PDF (136.3 KB)
  • 151 Views
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Article
Thymidine Kinase 1 is a Potential Marker for Prognosis and Monitoring the Response to Treatment of Patients with Breast, Lung, and Esophageal Cancer and Non-Hodgkin's Lymphoma
E. He, X. H. Xu, H. Guan, Y. Chen, Z. H. Chen, Z. L. Pan, L. L. Tang, G. Z. Hu, Y. Li, M. Zhang, J. Zhou, S. Eriksson, T. Fornander & S. Skog
Pages: 352-358
Published online: 11 Jun 2010
AbstractforThymidine Kinase 1 is a Potential Marker for Prognosis and Monitoring the Response to Treatment of Patients with Breast, Lung, and Esophageal Cancer and Non-Hodgkin's Lymphoma | Full Text | References | PDF (183 KB)
  • 235 Views
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Article
Pasteurella Multocida Thymidine Kinase 1 Efficiently Activates Pyrimidine Nucleoside Analogs
A. R. Clausen, S. A. L. Al Meani & J. Piškur
Pages: 359-362
Published online: 11 Jun 2010
AbstractforPasteurella Multocida Thymidine Kinase 1 Efficiently Activates Pyrimidine Nucleoside Analogs | Full Text | References | PDF (52.7 KB)
  • 53 Views
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Article
Enzymatic Regulation of Cytosolic Thymidine Kinase 1 and Mitochondrial Thymidine Kinase 2: A Mini Review
B. Munch-Petersen
Pages: 363-369
Published online: 11 Jun 2010
AbstractforEnzymatic Regulation of Cytosolic Thymidine Kinase 1 and Mitochondrial Thymidine Kinase 2: A Mini Review | Full Text | References | PDF (94.3 KB)
  • 540 Views
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Article
Deoxynucleoside Salvage Enzymes and Tissue Specific Mitochondrial DNA Depletion
L. Wang
Pages: 370-381
Published online: 11 Jun 2010
AbstractforDeoxynucleoside Salvage Enzymes and Tissue Specific Mitochondrial DNA Depletion | Full Text | References | PDF (195.2 KB)
  • 146 Views
  • 15 CrossRef citations
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Article
Identification and Characterization of Mitochondrial Factors Modulating Thymidine Kinase 2 Activity
R. Sun, S. Eriksson & L. Wang
Pages: 382-385
Published online: 11 Jun 2010
AbstractforIdentification and Characterization of Mitochondrial Factors Modulating Thymidine Kinase 2 Activity | Full Text | References | PDF (101 KB)
  • 117 Views
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Article
The Activity of the Lipophilic Nucleoside Derivatives Elacytarabine and CP-4126 in a Panel of Tumor Cell Lines Resistant to Nucleoside Analogues
Marit Liland Sandvold, Carlos Galmarini, Finn Myhren & Godefridus Peters
Pages: 386-393
Published online: 11 Jun 2010
AbstractforThe Activity of the Lipophilic Nucleoside Derivatives Elacytarabine and CP-4126 in a Panel of Tumor Cell Lines Resistant to Nucleoside Analogues | Full Text | References | PDF (131.5 KB)
  • 190 Views
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Article
Induction of Resistance to the Lipophilic Cytarabine Prodrug Elacytarabine (CP-4055) in CEM Leukemic Cells
A. D. Adema, N. Losekoot, K. Smid, I. Kathmann, F. Myhren, M. L. Sandvold & G. J. Peters
Pages: 394-399
Published online: 11 Jun 2010
AbstractforInduction of Resistance to the Lipophilic Cytarabine Prodrug Elacytarabine (CP-4055) in CEM Leukemic Cells | Full Text | References | PDF (107.7 KB)
  • 157 Views
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Article
Tissue Specific Distribution of Pyrimidine Deoxynucleoside Salvage Enzymes Shed Light on the Mechanism of Mitochondrial DNA Depletion
L. Wang & S. Eriksson
Pages: 400-403
Published online: 11 Jun 2010
AbstractforTissue Specific Distribution of Pyrimidine Deoxynucleoside Salvage Enzymes Shed Light on the Mechanism of Mitochondrial DNA Depletion | Full Text | References | PDF (112 KB)
  • 143 Views
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Article
Influence of Phosphorylation of THR-3, SER-11, and SER-15 on Deoxycytidine Kinase Activity and Stability
C. Smal, S. Ntamashimikiro, A. Arts, E. Van Den Neste & F. Bontemps
Pages: 404-407
Published online: 11 Jun 2010
AbstractforInfluence of Phosphorylation of THR-3, SER-11, and SER-15 on Deoxycytidine Kinase Activity and Stability | Full Text | References | PDF (107.2 KB)
  • 51 Views
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Article
Methylation Specific PCR to Characterize Methylation of the Promoter of Deoxycytidine Kinase
G. J. Peters, J. Hodzic, B. Ortega, E. Giovannetti, A. D. Adema, R. Broekhuizen, G. J. Kaspers & I. Hubeek
Pages: 408-413
Published online: 11 Jun 2010
AbstractforMethylation Specific PCR to Characterize Methylation of the Promoter of Deoxycytidine Kinase | Full Text | References | PDF (95.2 KB)
  • 159 Views
  • 9 CrossRef citations
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Article
Effect of Clofarabine on Apoptosis and DNA Synthesis in Human Epithelial Colon Cancer Cells
X. Wang & F. Albertioni
Pages: 414-418
Published online: 11 Jun 2010
AbstractforEffect of Clofarabine on Apoptosis and DNA Synthesis in Human Epithelial Colon Cancer Cells | Full Text | References | PDF (183 KB)
  • 166 Views
  • 5 CrossRef citations
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Article
Study of Apoptosis Induction and Deoxycytidine Kinase/Cytidine Deaminase Modulation in the Synergistic Interaction of a Novel Ceramide Analog and Gemcitabine in Pancreatic Cancer Cells
E. Giovannetti, L. G. Leon, S. Bertini, M. Macchia, F. Minutolo, N. Funel, C. Alecci, F. Giancola, R. Danesi & G. J. Peters
Pages: 419-426
Published online: 11 Jun 2010
AbstractforStudy of Apoptosis Induction and Deoxycytidine Kinase/Cytidine Deaminase Modulation in the Synergistic Interaction of a Novel Ceramide Analog and Gemcitabine in Pancreatic Cancer Cells | Full Text | References | PDF (139.7 KB)
  • 119 Views
  • 11 CrossRef citations
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Article
How to Use the Computing Environment R to Analyze ATP-Induced Ribonucleotide Reductase R1 Hexamerization Data
T. Radivoyevitch
Pages: 427-432
Published online: 11 Jun 2010
AbstractforHow to Use the Computing Environment R to Analyze ATP-Induced Ribonucleotide Reductase R1 Hexamerization Data | Full Text | References | PDF (81 KB)
  • 29 Views
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Article
Ribosylurea Accumulates in Yeast urc4 Mutants
O. Björnberg, M. Vodnala, V. Domkin, A. Hofer, A. Rasmussen, G. Andersen & J. Piškur
Pages: 433-437
Published online: 11 Jun 2010
AbstractforRibosylurea Accumulates in Yeast urc4 Mutants | Full Text | References | PDF (166.3 KB)
  • 189 Views
  • 11 CrossRef citations
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Article
Synthesis, Biological Properties and Anti-HIV-1 Activity of New Pyrimidine P1,P2-Dinucleotides
A. Miazga, P. Ziemkowski, M. A. Siwecka, A. Lipniacki, A. Piasek & T. Kulikowski
Pages: 438-444
Published online: 11 Jun 2010
AbstractforSynthesis, Biological Properties and Anti-HIV-1 Activity of New Pyrimidine P1,P2-Dinucleotides | Full Text | References | PDF (215.6 KB)
  • 100 Views
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Article
Nucleoside Phosphorylases from Clostridium Perfringens in the Synthesis of 2′,3′-Dideoxyinosine
S. Christoffersen, I. Serra, M. Terreni & J. Piškur
Pages: 445-448
Published online: 11 Jun 2010
AbstractforNucleoside Phosphorylases from Clostridium Perfringens in the Synthesis of 2′,3′-Dideoxyinosine | Full Text | References | PDF (54.3 KB)
  • 74 Views
  • 9 CrossRef citations
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Article
Protection of Mouse Heart Against Hypoxic Damage by AMP Deaminase Inhibition
T. Borkowski, E. M. Slominska, C. Orlewska, S. Chlopicki, P. Siondalski, M. H. Yacoub & R. T. Smolenski
Pages: 449-452
Published online: 11 Jun 2010
AbstractforProtection of Mouse Heart Against Hypoxic Damage by AMP Deaminase Inhibition | Full Text | References | PDF (140.3 KB)
  • 89 Views
  • 5 CrossRef citations
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Article
Cardiac Muscle AMP-Deaminase from a 10-Year-Old Male Heterozygous for the AMPD1 C34T Mutation
I. Rybakowska, S. Bakuła, J. Klimek, R. Milczarek, R. T. Smolenski & K. Kaletha
Pages: 453-456
Published online: 11 Jun 2010
AbstractforCardiac Muscle AMP-Deaminase from a 10-Year-Old Male Heterozygous for the AMPD1 C34T Mutation | Full Text | References | PDF (108.7 KB)
  • 50 Views
  • 3 CrossRef citations
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Article
Biological Efficiency of AMP Deaminase Inhibitor: 3-[2-(3-CARBOXY-4-BROMO-5,6,7,8-Tetrahydronaphthyl)Ethyl]-3,6,7,8-Tetrahydroimidazo[4,5]-[1,3]Diazepin-8-OL
T. Borkowski, E. M. Slominska, C. Orlewska, A. H. Y. Yuen, S. Al-Ayoubi, P. Siondalski, M. H. Yacoub & R. T. Smolenski
Pages: 457-460
Published online: 11 Jun 2010
AbstractforBiological Efficiency of AMP Deaminase Inhibitor: 3-[2-(3-CARBOXY-4-BROMO-5,6,7,8-Tetrahydronaphthyl)Ethyl]-3,6,7,8-Tetrahydroimidazo[4,5]-[1,3]Diazepin-8-OL | Full Text | References | PDF (138.9 KB)
  • 89 Views
  • 3 CrossRef citations
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Article
Determination of Adenosine Deaminase Activity in Dried Blood Spots by a Nonradiochemical Assay Using Reversed-Phase High-Performance Liquid Chromatography
A. B. P. van Kuilenburg, L. Zoetekouw, J. Meijer & T. W. Kuijpers
Pages: 461-465
Published online: 11 Jun 2010
AbstractforDetermination of Adenosine Deaminase Activity in Dried Blood Spots by a Nonradiochemical Assay Using Reversed-Phase High-Performance Liquid Chromatography | Full Text | References | PDF (162.8 KB)
  • 138 Views
  • 3 CrossRef citations
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Article
Identification of Purine Nucleoside Phosphorylase Deficiency in Dried Blood Spots by a Non-Radiochemical Assay Using Reversed-Phase High-Performance Liquid Chromatography
A. B. P. van Kuilenburg, L. Zoetekouw, J. Meijer & T. W. Kuijpers
Pages: 466-470
Published online: 11 Jun 2010
AbstractforIdentification of Purine Nucleoside Phosphorylase Deficiency in Dried Blood Spots by a Non-Radiochemical Assay Using Reversed-Phase High-Performance Liquid Chromatography | Full Text | References | PDF (142.2 KB)
  • 87 Views
  • 4 CrossRef citations
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Article
PARP Activity and NAD Concentration in PMC from Patients Affected by Systemic Sclerosis and Lupus Erythematosus
B. Cerboni, A. Di Stefano, V. Micheli, G. Morozzi, G. Pompucci & S. Sestini
Pages: 471-475
Published online: 11 Jun 2010
AbstractforPARP Activity and NAD Concentration in PMC from Patients Affected by Systemic Sclerosis and Lupus Erythematosus | Full Text | References | PDF (149.3 KB)
  • 87 Views
  • 6 CrossRef citations
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Article
Region-Specific Distribution of Dihydroorotate Dehydrogenase in the Rat Central Nervous System Points to Pyrimidine De Novo Synthesis in Neurons
Ch. M. Schaefer, M. K.-H. Schäfer & M. Löffler
Pages: 476-481
Published online: 11 Jun 2010
AbstractforRegion-Specific Distribution of Dihydroorotate Dehydrogenase in the Rat Central Nervous System Points to Pyrimidine De Novo Synthesis in Neurons | Full Text | References | PDF (480.8 KB)
  • 174 Views
  • 14 CrossRef citations
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Article
Increased Migration by Stimulation of Thymidine Phosphorylase in Endothelial Cells of Different Origin
I. V. Bijnsdorp, K. Vrijland, L. Vroling, M. Fukushima & G. J. Peters
Pages: 482-487
Published online: 11 Jun 2010
AbstractforIncreased Migration by Stimulation of Thymidine Phosphorylase in Endothelial Cells of Different Origin | Full Text | References | PDF (156.7 KB)
  • 74 Views
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Article
Activation of Stat1, IRF-1, and NF-κB is Required for the Induction of Uridine Phosphorylase by Tumor Necrosis Factor-α and Interferon-γ
Laxiang Wan, Deliang Cao, Jianmin Zeng, Amy Ziemba & Giuseppe Pizzorno
Pages: 488-503
Published online: 11 Jun 2010
AbstractforActivation of Stat1, IRF-1, and NF-κB is Required for the Induction of Uridine Phosphorylase by Tumor Necrosis Factor-α and Interferon-γ | Full Text | References | PDF (358.7 KB)
  • 165 Views
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Article
Relationship Between Plasma Uridine and Insulin Resistance in Patients with Non-Insulin-Dependent Diabetes Mellitus
Tetsuya Yamamoto, Taku Inokuchi, Tuneyoshi Ka, Asako Yamamoto, Sumio Takahashi, Zenta Tsutsumi, Daisuke Tamada, Chiharu Okuda & Yuji Moriwaki
Pages: 504-508
Published online: 11 Jun 2010
AbstractforRelationship Between Plasma Uridine and Insulin Resistance in Patients with Non-Insulin-Dependent Diabetes Mellitus | Full Text | References | PDF (113.1 KB)
  • 160 Views
  • 17 CrossRef citations
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Article
Dihydropyrimidine Dehydrogenase Deficiency Caused by a Novel Genomic Deletion c.505_513del of DPYD
A. B. P. van Kuilenburg, J. Meijer, G. Gökcay, T. Baykal, M. E. Rubio-Gozalbo, A. N. P. M. Mul, C. E. M. de Die-Smulders, P. Weber, A. Capone Mori, J. Bierau, B. Fowler, K. Macke, J. O. Sass, R. Meinsma, J. B. Hennermann, P. Miny, L. Zoetekouw, J. Roelofsen, R. Vijzelaar, J. Nicolai & R. C. M. Hennekam
Pages: 509-514
Published online: 11 Jun 2010
AbstractforDihydropyrimidine Dehydrogenase Deficiency Caused by a Novel Genomic Deletion c.505_513del of DPYD | Full Text | References | PDF (143.2 KB)
  • 307 Views
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Article
Development of LC-MS Method for Detection of Mutant Uromodulin Protein
M. Yasuda, K. Kaneko, H. Hachisu, M. Ochiai, T. Yamanobe, K. Mawatari, K. Nakagomi, N. Minoura & M. Hosoyamada
Pages: 515-517
Published online: 11 Jun 2010
AbstractforDevelopment of LC-MS Method for Detection of Mutant Uromodulin Protein | Full Text | References | PDF (169.2 KB)
  • 74 Views
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Article
Analysis of Purine in Purine-Rich Cauliflower
N. Yamaoka, K. Kaneko, Y. Kudo, M. Aoki, M. Yasuda, K. Mawatari, K. Nakagomi, Y. Yamada & T. Yamamoto
Pages: 518-521
Published online: 11 Jun 2010
AbstractforAnalysis of Purine in Purine-Rich Cauliflower | Full Text | References | PDF (47 KB)
  • 258 Views
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Article
Proceedings of the 13th International Symposium on Purine and Pyrimidine Metabolism in Man
S. Eriksson & G. J. Peters
Pages: i-bl-iii-bl
Published online: 11 Jun 2010
First Page PreviewforProceedings of the 13th International Symposium on Purine and Pyrimidine Metabolism in Man | Full Text | PDF (54.5 KB)
  • 30 Views
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