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ORIGINAL RESEARCH

Augmentation Therapy for α1 Antitrypsin Deficiency: A Meta-Analysis

, MD, , MD, DSc, , MD, , PhD & , PhD
Pages 177-184 | Published online: 18 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (29)

James A Stockley, Robert A Stockley & Elizabeth Sapey. (2021) There is No Fast Track to Identify Fast Decliners in Alpha-1 Antitrypsin Deficiency by Spirometry: A Longitudinal Study of Repeated Measurements. International Journal of Chronic Obstructive Pulmonary Disease 16, pages 835-840.
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Mark Quinn, Paul Ellis, Anita Pye & Alice M Turner. (2020) Obstacles to Early Diagnosis and Treatment of Alpha-1 Antitrypsin Deficiency: Current Perspectives. Therapeutics and Clinical Risk Management 16, pages 1243-1255.
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Kylie B R Belchamber, Eloise M Walker, Robert A Stockley & Elizabeth Sapey. (2020) Monocytes and Macrophages in Alpha-1 Antitrypsin Deficiency. International Journal of Chronic Obstructive Pulmonary Disease 15, pages 3183-3192.
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Franck F Rahaghi, Richard Monk, Viswanathan Ramakrishnan, Tatsiana Beiko & Charlie Strange. (2020) Alpha-1 Antitrypsin Augmentation Therapy Improves Survival in Severely Deficient Patients with Predicted FEV1 Between 10% and 60%: A Retrospective Analysis of the NHLBI Alpha-1 Antitrypsin Deficiency Registry. International Journal of Chronic Obstructive Pulmonary Disease 15, pages 3193-3199.
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Kenneth R Chapman, Joanna Chorostowska-Wynimko, A Rembert Koczulla, Ilaria Ferrarotti & Noel G McElvaney. (2018) Alpha 1 antitrypsin to treat lung disease in alpha 1 antitrypsin deficiency: recent developments and clinical implications. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 419-432.
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Mario Cazzola, Paola Rogliani, Ermanno Puxeddu, Josuel Ora & Maria Gabriella Matera. (2018) An overview of the current management of chronic obstructive pulmonary disease: can we go beyond the GOLD recommendations?. Expert Review of Respiratory Medicine 12:1, pages 43-54.
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Jorge E. Lascano & Michael A. Campos. (2017) The important role of primary care providers in the detection of alpha-1 antitrypsin deficiency. Postgraduate Medicine 129:8, pages 889-895.
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Ross G Edgar, Mitesh Patel, Susan Bayliss, Diana Crossley, Elizabeth Sapey & Alice M Turner. (2017) Treatment of lung disease in alpha-1 antitrypsin deficiency: a systematic review. International Journal of Chronic Obstructive Pulmonary Disease 12, pages 1295-1308.
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Maria Paula Henao & Timothy J. Craig. (2016) Recent advances in understanding and treating COPD related to α1-antitrypsin deficiency. Expert Review of Respiratory Medicine 10:12, pages 1281-1294.
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Joanna Chorostowska-Wynimko. (2016) Disease Modification in Emphysema Related to Alpha-1 Antitrypsin Deficiency. COPD: Journal of Chronic Obstructive Pulmonary Disease 13:6, pages 807-815.
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Robert A Stockley, Ross G Edgar, Anilkumar Pillai & Alice M Turner. (2016) Individualized lung function trends in alpha-1-antitrypsin deficiency: a need for patience in order to provide patient centered management?. International Journal of Chronic Obstructive Pulmonary Disease 11, pages 1745-1756.
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Sanjay H Chotirmall, Mazen Al-Alawi, Thomas McEnery & Noel G McElvaney. (2015) Alpha-1 proteinase inhibitors for the treatment of alpha-1 antitrypsin deficiency: safety, tolerability, and patient outcomes. Therapeutics and Clinical Risk Management 11, pages 143-151.
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Katrin Milger, Lesca Miriam Holdt, Daniel Teupser, Rudolf Maria Huber, Jürgen Behr & Nikolaus Kneidinger. (2015) Identification of a novel SERPINA-1 mutation causing alpha-1 antitrypsin deficiency in a patient with severe bronchiectasis and pulmonary embolism. International Journal of Chronic Obstructive Pulmonary Disease 10, pages 891-897.
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Robert A. Stockley. (2015) Antitrypsin Deficiency Assessment and Programme for Treatment (ADAPT): The United Kingdom Registry. COPD: Journal of Chronic Obstructive Pulmonary Disease 12:sup1, pages 63-68.
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Ana C. Bradi, Nadeen Audisho, Deborah K. Casey & Kenneth R. Chapman. (2015) Alpha-1 Antitrypsin Deficiency in Canada: Regional Disparities in Diagnosis and Management. COPD: Journal of Chronic Obstructive Pulmonary Disease 12:sup1, pages 15-21.
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Robert A. Sandhaus, James Stocks, Farshid N. Rouhani, Mark Brantly & Pnina Strauss. (2014) Biochemical Efficacy and Safety of a New, Ready-to-Use, Liquid Alpha-1-Proteinase Inhibitor, GLASSIA (Alpha1-Proteinase Inhibitor (Human), Intravenous). COPD: Journal of Chronic Obstructive Pulmonary Disease 11:1, pages 17-25.
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Judith A Brebner & Robert A Stockley. (2013) Recent advances in α-1-antitrypsin deficiency-related lung disease. Expert Review of Respiratory Medicine 7:3, pages 213-230.
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Robert A. Stockley, Asger Dirksen & Jan Stolk. (2013) Alpha-1 Antitrypsin Deficiency: The European Experience. COPD: Journal of Chronic Obstructive Pulmonary Disease 10:sup1, pages 50-53.
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Xiaobo Li, Na Wei, Zhangjun Wu, Zhanzhong Qi, Xin Zhang, Qiuling Chen, Zhiqiang Xia & Shuo Li. (2012) The D/I Polymorphism in the Angiotensin-Converting Enzyme Gene and Chronic Obstructive Pulmonary Disease Risk: A Meta-Analysis. COPD: Journal of Chronic Obstructive Pulmonary Disease 9:5, pages 485-491.
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Manish Mohanka, Danai Khemasuwan & James K Stoller. (2012) A review of augmentation therapy for alpha-1 antitrypsin deficiency. Expert Opinion on Biological Therapy 12:6, pages 685-700.
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Raja T Abboud, Tanya N Nelson, Benjamin Jung & Andre Mattman. (2011) Alpha1-antitrypsin deficiency: a clinical-genetic overview. The Application of Clinical Genetics 4, pages 55-65.
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Catherine M Greene, Tidi Hassan, Kevin Molloy & Noel G McElvaney. (2011) The role of proteases, endoplasmic reticulum stress and SERPINA1 heterozygosity in lung disease and α-1 anti-trypsin deficiency. Expert Review of Respiratory Medicine 5:3, pages 395-411.
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F. Kueppers. (2011) The role of augmentation therapy in alpha-1 antitrypsin deficiency. Current Medical Research and Opinion 27:3, pages 579-588.
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Robert A Stockley. (2010) Emerging drugs for alpha-1-antitrypsin deficiency. Expert Opinion on Emerging Drugs 15:4, pages 685-694.
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Alan F. Barker. (2010) Alpha-1 Antitrypsin Deficiency Identification and Management: It is the Team More than the Genes. COPD: Journal of Chronic Obstructive Pulmonary Disease 7:3, pages 162-163.
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Kenneth R. Chapman, Robert A. Stockley, Mahlon M. Wilkes & Roberta J. Navickis. (2010) Letter to the Editor Response. COPD: Journal of Chronic Obstructive Pulmonary Disease 7:3, pages 235-236.
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Cormac McCarthy & Borislav D. Dimitrov. (2010) Augmentation Therapy for Alpha-1 Antitrypsin Deficiency—Not Enough Evidence to Support its Use Yet!. COPD: Journal of Chronic Obstructive Pulmonary Disease 7:3, pages 234-234.
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