Cancer Biology & Therapy, Volume 16, Issue 4 (2015)

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Cancer Biology & Therapy, Volume 16, Issue 4 (2015)

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Bedside to Bench Report

Article
Five years of stable disease with maintenance therapy using bevacizumab and tamoxifen in a patient with metastatic breast cancer
Giandomenico Roviello, Edoardo Francini, Armando Perrella, Letizia Laera, Maria Antonietta Mazzei, Susanna Guerrini, Franco Roviello, Daniele Marrelli & Roberto Petrioli
Pages: 493-497
Published online: 03 Apr 2015
AbstractforFive years of stable disease with maintenance therapy using bevacizumab and tamoxifen in a patient with metastatic breast cancer | Full Text | References | PDF (365.2 KB)
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Research Paper

Article
The expression of P2X7 receptors in EPCs and their potential role in the targeting of EPCs to brain gliomas
Jingqin Fang, Xiao Chen, Shunan Wang, Tian Xie, Xuesong Du, Heng Liu, Sumei Wang, Xue Li, Jinhua Chen, Bo Zhang, Huaping Liang, Yizeng Yang & Weiguo Zhang
Pages: 498-510
Published online: 03 Apr 2015
AbstractforThe expression of P2X7 receptors in EPCs and their potential role in the targeting of EPCs to brain gliomas | Full Text | References | PDF (1.2 MB)
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Article
HMGB1-mediated autophagy modulates sensitivity of colorectal cancer cells to oxaliplatin via MEK/ERK signaling pathway
Weijun Liu, Zhenyong Zhang, Yongxue Zhang, Xinju Chen, Shikui Guo, Yi Lei, Yu Xu, Chao Ji, Zhigang Bi & Kunhua Wang
Pages: 511-517
Published online: 03 Apr 2015
AbstractforHMGB1-mediated autophagy modulates sensitivity of colorectal cancer cells to oxaliplatin via MEK/ERK signaling pathway | Full Text | References | PDF (656.9 KB)
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Article
Downregulation of hPMC2 imparts chemotherapeutic sensitivity to alkylating agents in breast cancer cells
Nirmala Krishnamurthy, Lili Liu, Xiahui Xiong, Junran Zhang & Monica M Montano
Pages: 518-527
Published online: 07 Apr 2015
AbstractforDownregulation of hPMC2 imparts chemotherapeutic sensitivity to alkylating agents in breast cancer cells | Full Text | References | PDF (534.3 KB)
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Article
RACK1 predicts poor prognosis and regulates progression of esophageal squamous cell carcinoma through its epithelial-mesenchymal transition
Nana Wang, Fang Liu, Fangli Cao, Yibin Jia, Jianbo Wang, Wei Ma, Bingxu Tan, Kai Wang, Qingxu Song & Yufeng Cheng
Pages: 528-540
Published online: 09 Apr 2015
AbstractforRACK1 predicts poor prognosis and regulates progression of esophageal squamous cell carcinoma through its epithelial-mesenchymal transition | Full Text | References | PDF (1.8 MB)
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Article
Downregulation of phosphoglycerate dehydrogenase inhibits proliferation and enhances cisplatin sensitivity in cervical adenocarcinoma cells by regulating Bcl-2 and caspase-3
Zhang Jing, Wei Heng, Liu Xia, Wang Ning, Qi Yafei, Zhang Yao & Zhang Shulan
Pages: 541-548
Published online: 09 Apr 2015
AbstractforDownregulation of phosphoglycerate dehydrogenase inhibits proliferation and enhances cisplatin sensitivity in cervical adenocarcinoma cells by regulating Bcl-2 and caspase-3 | Full Text | References | PDF (609.7 KB)
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Article
Endothelial PAS domain-containing protein 1 confers TKI-resistance by mediating EGFR and MET pathways in non-small cell lung cancer cells
Qiang Zhen, Jun-Feng Liu, Jia-Bao Liu, Ren-Feng Wang, Wei-Wei Chu, Ya-Xiao Zhang, Guo-Liang Tan, Xiao-Jian Zhao & Bao-Lei Lv
Pages: 549-557
Published online: 13 Apr 2015
AbstractforEndothelial PAS domain-containing protein 1 confers TKI-resistance by mediating EGFR and MET pathways in non-small cell lung cancer cells | Full Text | References | PDF (807.3 KB) | Supplemental
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Article
Radioresistance in a human laryngeal squamous cell carcinoma cell line is associated with DNA methylation changes and topoisomerase II α
Jae-Sung Kim, Sun Young Kim, Minyoung Lee, Sung Hyun Kim, Sang-Man Kim & Eun Ju Kim
Pages: 558-566
Published online: 13 Apr 2015
AbstractforRadioresistance in a human laryngeal squamous cell carcinoma cell line is associated with DNA methylation changes and topoisomerase II α | Full Text | References | PDF (692.5 KB)
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Article
Antagonistic effects of chloroquine on autophagy occurrence potentiate the anticancer effects of everolimus on renal cancer cells
A Grimaldi, D Santini, S Zappavigna, A Lombardi, G Misso, M Boccellino, V Desiderio, P P Vitiello, G Di Lorenzo, A Zoccoli, F Pantano & M Caraglia
Pages: 567-579
Published online: 11 Apr 2015
AbstractforAntagonistic effects of chloroquine on autophagy occurrence potentiate the anticancer effects of everolimus on renal cancer cells | Full Text | References | PDF (1.2 MB)
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Article
Co-targeting of Akt and Myc inhibits viability of lymphoma cells from Lck-Dlx5 mice
Yinfei Tan, Eleonora Sementino, Jianming Pei, Yuwaraj Kadariya, Timothy K Ito & Joseph R Testa
Pages: 580-588
Published online: 11 Apr 2015
AbstractforCo-targeting of Akt and Myc inhibits viability of lymphoma cells from Lck-Dlx5 mice | Full Text | References | PDF (646.8 KB) | Supplemental
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Article
Small molecule schweinfurthins selectively inhibit cancer cell proliferation and mTOR/AKT signaling by interfering with trans-Golgi-network trafficking
Xingfeng Bao, Wanjun Zheng, Naoko Hata Sugi, Kishan L Agarwala, Qunli Xu, Zichun Wang, Karen Tendyke, Winnie Lee, Lana Parent, Wei Li, Hongsheng Cheng, Yongchun Shen, Noel Taylor, Zoltan Dezso, Hong Du, Yoshihiko Kotake, Nanding Zhao, John Wang, Maarten Postema, Mary Woodall-Jappe, Yasutaka Takase, Toshimitsu Uenaka, David G I Kingston & Kenichi Nomoto
Pages: 589-601
Published online: 13 Apr 2015
AbstractforSmall molecule schweinfurthins selectively inhibit cancer cell proliferation and mTOR/AKT signaling by interfering with trans-Golgi-network trafficking | Full Text | References | PDF (1.1 MB) | Supplemental
  • 1770 Views
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Article
Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against osteosarcoma
Yun-Rong Zhu, Han Min, Jian-Feng Fang, Feng Zhou, Xiong-Wei Deng & Yun-Qing Zhang
Pages: 602-609
Published online: 14 Apr 2015
AbstractforActivity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against osteosarcoma | Full Text | References | PDF (922.5 KB)
  • 1085 Views
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Article
Pre-clinical activity of PR-104 as monotherapy and in combination with sorafenib in hepatocellular carcinoma
Maria R Abbattista, Stephen M F Jamieson, Yongchuan Gu, Jennifer E Nickel, Susan M Pullen, Adam V Patterson, William R Wilson & Christopher P Guise
Pages: 610-622
Published online: 14 Apr 2015
AbstractforPre-clinical activity of PR-104 as monotherapy and in combination with sorafenib in hepatocellular carcinoma | Full Text | References | PDF (867.2 KB)
  • 1715 Views
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Article
Imp2 regulates GBM progression by activating IGF2/PI3K/Akt pathway
Qingchun Mu, Lijun Wang, Fengbo Yu, Haijun Gao, Ting Lei, Peiwen Li, Pengfei Liu, Xu Zheng, Xitong Hu, Yong Chen, Zhenfeng Jiang, Arash J Sayari, Jia Shen & Haiyan Huang
Pages: 623-633
Published online: 15 Apr 2015
AbstractforImp2 regulates GBM progression by activating IGF2/PI3K/Akt pathway | Full Text | References | PDF (1.3 MB)
  • 2166 Views
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Article
Blocking M2 muscarinic receptor signaling inhibits tumor growth and reverses epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC)
Qingnan Zhao, Xiajing Gu, Chun Zhang, Qin Lu, Hongzhuan Chen & Lu Xu
Pages: 634-643
Published online: 15 Apr 2015
AbstractforBlocking M2 muscarinic receptor signaling inhibits tumor growth and reverses epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC) | Full Text | References | PDF (764.5 KB) | Supplemental
  • 1296 Views
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