mAbs, Volume 7, Issue 1 (2015)

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mAbs, Volume 7, Issue 1 (2015)

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Editor's Corner

Editorial
Antibodies to watch in 2015
Janice M Reichert
Pages: 1-8
Published online: 14 Jan 2015
AbstractforAntibodies to watch in 2015 | Full Text | References | PDF (133.4 KB)
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Reviews

Review
The therapeutic monoclonal antibody market
Dawn M Ecker, Susan Dana Jones & Howard L Levine
Pages: 9-14
Published online: 14 Jan 2015
AbstractforThe therapeutic monoclonal antibody market | Full Text | References | PDF (328 KB)
  • 49365 Views
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Review

Review
Structural insights and biomedical potential of IgNAR scaffolds from sharks
Stefan Zielonka, Martin Empting, Julius Grzeschik, Doreen Könning, Caroline J Barelle & Harald Kolmar
Pages: 15-25
Published online: 14 Jan 2015
AbstractforStructural insights and biomedical potential of IgNAR scaffolds from sharks | Full Text | References | PDF (827.3 KB)
  • 6825 Views
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Brief Reports

Brief Report
Large scale production of phage antibody libraries using a bioreactor
Fortunato Ferrara, Chang-Yub Kim, Leslie A Naranjo & Andrew RM Bradbury
Pages: 26-31
Published online: 14 Jan 2015
AbstractforLarge scale production of phage antibody libraries using a bioreactor | Full Text | References | PDF (486.8 KB)
  • 1901 Views
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Reports

Report
Recombinant renewable polyclonal antibodies
Fortunato Ferrara, Sara D’Angelo, Tiziano Gaiotto, Leslie Naranjo, Hongzhao Tian, Susanne Gräslund, Elena Dobrovetsky, Peter Hraber, Fridtjof Lund-Johansen, Silvia Saragozza, Daniele Sblattero, Csaba Kiss & Andrew RM Bradbury
Pages: 32-41
Published online: 14 Jan 2015
AbstractforRecombinant renewable polyclonal antibodies | Full Text | References | PDF (807.7 KB) | Supplemental
  • 3468 Views
  • 30 CrossRef citations
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Report

Report
Comprehensive optimization of a single-chain variable domain antibody fragment as a targeting ligand for a cytotoxic nanoparticle
Kathy Zhang, Melissa L Geddie, Neeraj Kohli, Tad Kornaga, Dmitri B Kirpotin, Yang Jiao, Rachel Rennard, Daryl C Drummond, Ulrik B Nielsen, Lihui Xu & Alexey A Lugovskoy
Pages: 42-52
Published online: 14 Jan 2015
AbstractforComprehensive optimization of a single-chain variable domain antibody fragment as a targeting ligand for a cytotoxic nanoparticle | Full Text | References | PDF (681.2 KB) | Supplemental
  • 2616 Views
  • 19 CrossRef citations
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Report
Nanocell targeting using engineered bispecific antibodies
Karin Taylor, Christopher B Howard, Martina L Jones, Ilya Sedliarou, Jennifer MacDiarmid, Himanshu Brahmbhatt, Trent P Munro & Stephen M Mahler
Pages: 53-65
Published online: 14 Jan 2015
AbstractforNanocell targeting using engineered bispecific antibodies | Full Text | References | PDF (1 MB)
  • 4061 Views
  • 33 CrossRef citations
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Report
Surrogate target cells expressing surface anti-idiotype antibody for the clinical evaluation of an internalizing CD22-specific antibody
Shui-on Leung, Kai Gao, Guang Yu Wang, Benny Ka-wa Cheung, Kwan-yeung Lee, Qi Zhao, Wing-Tai Cheung & Jun Zhi Wang
Pages: 66-76
Published online: 14 Jan 2015
AbstractforSurrogate target cells expressing surface anti-idiotype antibody for the clinical evaluation of an internalizing CD22-specific antibody | Full Text | References | PDF (770.2 KB)
  • 1141 Views
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Report
Early developability screen of therapeutic antibody candidates using Taylor dispersion analysis and UV area imaging detection
Alexandra Lavoisier & Jean-Marc Schlaeppi
Pages: 77-83
Published online: 14 Jan 2015
AbstractforEarly developability screen of therapeutic antibody candidates using Taylor dispersion analysis and UV area imaging detection | Full Text | References | PDF (417.8 KB) | Supplemental
  • 3333 Views
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Report
Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life
Ranajoy Majumdar, Reza Esfandiary, Steven M Bishop, Hardeep S Samra, C Russell Middaugh, David B Volkin & David D Weis
Pages: 84-95
Published online: 14 Jan 2015
AbstractforCorrelations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life | Full Text | References | PDF (950 KB) | Supplemental
  • 3967 Views
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Report
High contrast tumor imaging with radio-labeled antibody Fab fragments tailored for optimized pharmacokinetics via PASylation
Claudia T Mendler, Lars Friedrich, Iina Laitinen, Martin Schlapschy, Markus Schwaiger, Hans-Jürgen Wester & Arne Skerra
Pages: 96-109
Published online: 14 Jan 2015
AbstractforHigh contrast tumor imaging with radio-labeled antibody Fab fragments tailored for optimized pharmacokinetics via PASylation | Full Text | References | PDF (605.1 KB) | Supplemental
  • 4059 Views
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Report
Characterization of monoclonal antibody's binding kinetics using oblique-incidence reflectivity difference approach
Shuang Liu, Hongyan Zhang, Jun Dai, Shaohui Hu, Ignacio Pino, Daniel J Eichinger, Huibin Lyu & Heng Zhu
Pages: 110-119
Published online: 14 Jan 2015
AbstractforCharacterization of monoclonal antibody's binding kinetics using oblique-incidence reflectivity difference approach | Full Text | References | PDF (885.3 KB) | Supplemental
  • 4492 Views
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Reports

Report
Non–antigen-contacting region of an asymmetric bispecific antibody to factors IXa/X significantly affects factor VIII-mimetic activity
Zenjiro Sampei, Tomoyuki Igawa, Tetsuhiro Soeda, Miho Funaki, Kazutaka Yoshihashi, Takehisa Kitazawa, Atsushi Muto, Tetsuo Kojima, Satoshi Nakamura & Kunihiro Hattori
Pages: 120-128
Published online: 14 Jan 2015
AbstractforNon–antigen-contacting region of an asymmetric bispecific antibody to factors IXa/X significantly affects factor VIII-mimetic activity | Full Text | References | PDF (611.3 KB) | Supplemental
  • 3233 Views
  • 15 CrossRef citations
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Report

Report
Generation of potent mouse monoclonal antibodies to self-proteins using T-cell epitope “tags”
Jennifer L Percival-Alwyn, Elizabeth England, Benjamin Kemp, Laura Rapley, Nicola HE Davis, Grant R McCarthy, Jayesh B Majithiya, Dominic J Corkill, Sarah Welsted, Kevin Minton, E Suzanne Cohen, Matthew J Robinson, Claire Dobson, Trevor CI Wilkinson, Tristan J Vaughan, Maria AT Groves & Natalie J Tigue
Pages: 129-137
Published online: 14 Jan 2015
AbstractforGeneration of potent mouse monoclonal antibodies to self-proteins using T-cell epitope “tags” | Full Text | References | PDF (298.7 KB) | Supplemental
  • 6069 Views
  • 11 CrossRef citations
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Report
A generic approach to engineer antibody pH-switches using combinatorial histidine scanning libraries and yeast display
Christian Schröter, Ralf Günther, Laura Rhiel, Stefan Becker, Lars Toleikis, Achim Doerner, Janine Becker, Andreas Schönemann, Daichi Nasu, Berend Neuteboom, Harald Kolmar & Björn Hock
Pages: 138-151
Published online: 14 Jan 2015
AbstractforA generic approach to engineer antibody pH-switches using combinatorial histidine scanning libraries and yeast display | Full Text | References | PDF (1.1 MB) | Supplemental
  • 7199 Views
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Report
Affinity maturation of a novel antagonistic human monoclonal antibody with a long VH CDR3 targeting the Class A GPCR formyl-peptide receptor 1
Julie A Douthwaite, Sudharsan Sridharan, Catherine Huntington, Jayne Hammersley, Rose Marwood, Jonna K Hakulinen, Margareta Ek, Tove Sjögren, David Rider, Cyril Privezentzev, Jonathan C Seaman, Peter Cariuk, Vikki Knights, Joyce Young, Trevor Wilkinson, Matthew Sleeman, Donna K Finch, David C Lowe & Tristan J Vaughan
Pages: 152-166
Published online: 14 Jan 2015
AbstractforAffinity maturation of a novel antagonistic human monoclonal antibody with a long VH CDR3 targeting the Class A GPCR formyl-peptide receptor 1 | Full Text | References | PDF (853.1 KB) | Supplemental
  • 4528 Views
  • 34 CrossRef citations
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Report
Comparison of methods for the analysis of therapeutic immunoglobulin G Fc-glycosylation profiles—Part 1: Separation-based methods
Dietmar Reusch, Markus Haberger, Bernd Maier, Maria Maier, Ronny Kloseck, Boris Zimmermann, Michaela Hook, Zoltan Szabo, Samnang Tep, Jo Wegstein, Nadja Alt, Patrick Bulau & Manfred Wuhrer
Pages: 167-179
Published online: 14 Jan 2015
AbstractforComparison of methods for the analysis of therapeutic immunoglobulin G Fc-glycosylation profiles—Part 1: Separation-based methods | Full Text | References | PDF (876.1 KB)
  • 10088 Views
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Reports

Report
Functional inhibition of β-catenin-mediatedWnt signaling by intracellular VHHantibodies
Laura E Newnham, Michael J Wright, Gill Holdsworth, Kostas Kostarelos, Martyn K Robinson, Terence H Rabbitts & Alastair D Lawson
Pages: 180-191
Published online: 14 Jan 2015
AbstractforFunctional inhibition of β-catenin-mediatedWnt signaling by intracellular VHHantibodies | Full Text | References | PDF (813.8 KB)
  • 2826 Views
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Report
Effect of kinase inhibitors on the therapeutic properties of monoclonal antibodies
Minh Ngoc Duong, Eva-Laure Matera, Doriane Mathé, Anne Evesque, Sandrine Valsesia-Wittmann, Béatrice Clémenceau & Charles Dumontet
Pages: 192-198
Published online: 14 Jan 2015
AbstractforEffect of kinase inhibitors on the therapeutic properties of monoclonal antibodies | Full Text | References | PDF (407 KB) | Supplemental
  • 1258 Views
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Report
Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells
Chien-Hsing Chang, Yang Wang, Pankaj Gupta & David M Goldenberg
Pages: 199-211
Published online: 14 Jan 2015
AbstractforExtensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells | Full Text | References | PDF (1.2 MB) | Supplemental
  • 2597 Views
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Report

Report
Rational design of viscosity reducing mutants of a monoclonal antibody: Hydrophobic versus electrostatic inter-molecular interactions
Pilarin Nichols, Li Li, Sandeep Kumar, Patrick M Buck, Satish K Singh, Sumit Goswami, Bryan Balthazor, Tami R Conley, David Sek & Martin J Allen
Pages: 212-230
Published online: 14 Jan 2015
AbstractforRational design of viscosity reducing mutants of a monoclonal antibody: Hydrophobic versus electrostatic inter-molecular interactions | Full Text | References | PDF (770.1 KB) | Supplemental
  • 4228 Views
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Reports

Report
Production of bispecific antibodies in “knobs-into-holes” using a cell-free expression system
Yiren Xu, John Lee, Cuong Tran, Tyler H Heibeck, Willie D Wang, Junhao Yang, Ryan L Stafford, Alexander R Steiner, Aaron K Sato, Trevor J Hallam & Gang Yin
Pages: 231-242
Published online: 14 Jan 2015
AbstractforProduction of bispecific antibodies in “knobs-into-holes” using a cell-free expression system | Full Text | References | PDF (770.1 KB) | Supplemental
  • 15078 Views
  • 60 CrossRef citations
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Report

Report
Five birds, one stone: Neutralization of α-hemolysin and 4 bi-component leukocidins of Staphylococcus aureus with a single human monoclonal antibody
Harald Rouha, Adriana Badarau, Zehra C Visram, Michael B Battles, Bianka Prinz, Zoltán Magyarics, Gábor Nagy, Irina Mirkina, Lukas Stulik, Manuel Zerbs, Michaela Jägerhofer, Barbara Maierhofer, Astrid Teubenbacher, Ivana Dolezilkova, Karin Gross, Srijib Banerjee, Gerhild Zauner, Stefan Malafa, Jakub Zmajkovic, Sabine Maier, Robert Mabry, Eric Krauland, K Dane Wittrup, Tillman U Gerngross & Eszter Nagy
Pages: 243-254
Published online: 14 Jan 2015
AbstractforFive birds, one stone: Neutralization of α-hemolysin and 4 bi-component leukocidins of Staphylococcus aureus with a single human monoclonal antibody | Full Text | References | PDF (970.2 KB) | Supplemental
  • 5709 Views
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Report
Evaluation of cetuximab as a candidate for targeted α-particle radiation therapy of HER1-positive disseminated intraperitoneal disease
Diane E Milenic, Kwamena E Baidoo, Young-Seung Kim & Martin W Brechbiel
Pages: 255-264
Published online: 14 Jan 2015
AbstractforEvaluation of cetuximab as a candidate for targeted α-particle radiation therapy of HER1-positive disseminated intraperitoneal disease | Full Text | References | PDF (555.2 KB)
  • 1186 Views
  • 27 CrossRef citations
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Report
Preclinical and early clinical development of GNbAC1, a humanized IgG4 monoclonal antibody targeting endogenous retroviral MSRV-Env protein
François Curtin, Hervé Perron, Arno Kromminga, Hervé Porchet & Alois B Lang
Pages: 265-275
Published online: 14 Jan 2015
AbstractforPreclinical and early clinical development of GNbAC1, a humanized IgG4 monoclonal antibody targeting endogenous retroviral MSRV-Env protein | Full Text | References | PDF (753.9 KB)
  • 2655 Views
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Reports

Report
Therapeutic monoclonal antibodies and the need for targeted pharmacovigilance in India
M Kalaivani, Abhishank Singh & V Kalaiselvan
Pages: 276-280
Published online: 14 Jan 2015
AbstractforTherapeutic monoclonal antibodies and the need for targeted pharmacovigilance in India | Full Text | References | PDF (173.8 KB)
  • 1236 Views
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