Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 31, Issue sup4 (2016)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 31, Issue sup4 (2016)

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Research Article

Article
Microwave-assisted extraction, HPLC analysis, and inhibitory effects on carbonic anhydrase I, II, VA, and VII isoforms of 14 blueberry Italian cultivars
Adriano Mollica, Marcello Locatelli, Giorgia Macedonio, Simone Carradori, Anatoly P. Sobolev, Roberto F. De Salvador, Simona M. Monti, Martina Buonanno, Gokhan Zengin, Andrea Angeli & Claudiu T. Supuran
Pages: 1-6
Published online: 10 Aug 2016
AbstractforMicrowave-assisted extraction, HPLC analysis, and inhibitory effects on carbonic anhydrase I, II, VA, and VII isoforms of 14 blueberry Italian cultivars | Full Text | References | PDF (300.1 KB) | Supplemental
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Article
Study of reactivity of cyanoacetohydrazonoethyl-N-ethyl-N-methyl benzenesulfonamide: preparation of novel anticancer and antimicrobial active heterocyclic benzenesulfonamide derivatives and their molecular docking against dihydrofolate reductase
Khaled F. Debbabi, Sami A. Al-Harbi, Hamed M. Al-Saidi, Enas H. Aljuhani, Shimaa M. Abd El-Gilil & Mahmoud S. Bashandy
Pages: 7-19
Published online: 24 Aug 2016
AbstractforStudy of reactivity of cyanoacetohydrazonoethyl-N-ethyl-N-methyl benzenesulfonamide: preparation of novel anticancer and antimicrobial active heterocyclic benzenesulfonamide derivatives and their molecular docking against dihydrofolate reductase | Full Text | References | PDF (567.6 KB) | Supplemental
  • 1376 Views
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Article
Synthesis, cytotoxicity and carbonic anhydrase inhibitory activities of new pyrazolines
Kaan Kucukoglu, Fatih Oral, Tevfik Aydin, Cem Yamali, Oztekin Algul, Hiroshi Sakagami, Ilhami Gulcin, Claudiu T. Supuran & Halise Inci Gul
Pages: 20-24
Published online: 31 Aug 2016
AbstractforSynthesis, cytotoxicity and carbonic anhydrase inhibitory activities of new pyrazolines | Full Text | References | PDF (333.3 KB) | Supplemental
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Article
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity
Marilena Tauro, Antonio Laghezza, Fulvio Loiodice, Luca Piemontese, Alessia Caradonna, Davide Capelli, Roberta Montanari, Giorgio Pochetti, Antonella Di Pizio, Mariangela Agamennone, Cristina Campestre & Paolo Tortorella
Pages: 25-37
Published online: 24 Aug 2016
AbstractforCatechol-based matrix metalloproteinase inhibitors with additional antioxidative activity | Full Text | References | PDF (1.7 MB) | Supplemental
  • 1507 Views
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Article
Selective inhibition of human carbonic anhydrase IX in Xenopus oocytes and MDA-MB-231 breast cancer cells
Justina Kazokaitė, Samantha Ames, Holger M. Becker, Joachim W. Deitmer & Daumantas Matulis
Pages: 38-44
Published online: 24 Aug 2016
AbstractforSelective inhibition of human carbonic anhydrase IX in Xenopus oocytes and MDA-MB-231 breast cancer cells | Full Text | References | PDF (790.4 KB) | Supplemental
  • 1041 Views
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Article
Inhibition of PID1/NYGGF4/PCLI1 gene expression highlights its role in the early events of the cell cycle in NIH3T3 fibroblasts
Francesca Monteleone, Monica Vitale, Ginevra Caratù, Chiara D’Ambrosio, Stefano Di Giovanni, Marisa Gorrese, Francesco Napolitano, Maria Fiammetta Romano, Luigi Del Vecchio, Mariangela Succoio, Andrea Scaloni & Nicola Zambrano
Pages: 45-53
Published online: 17 Aug 2016
AbstractforInhibition of PID1/NYGGF4/PCLI1 gene expression highlights its role in the early events of the cell cycle in NIH3T3 fibroblasts | Full Text | References | PDF (838.9 KB)
  • 967 Views
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Article
Cloning, expression and purification of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum
Sonia Del Prete, Viviana De Luca, Giuseppina De Simone, Claudiu T. Supuran & Clemente Capasso
Pages: 54-59
Published online: 15 Aug 2016
AbstractforCloning, expression and purification of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum | Full Text | References | PDF (382 KB)
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Article
Overexpression of the transmembrane carbonic anhydrase isoforms IX and XII in the inflamed synovium
Francesca Margheri, Mariangela Ceruso, Fabrizio Carta, Anna Laurenzana, Laura Maggi, Simone Lazzeri, Gabriele Simonini, Francesco Annunziato, Mario Del Rosso, Claudiu T. Supuran & Rolando Cimaz
Pages: 60-63
Published online: 15 Aug 2016
AbstractforOverexpression of the transmembrane carbonic anhydrase isoforms IX and XII in the inflamed synovium | Full Text | References | PDF (418.2 KB)
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Article
Discovery of new heat shock protein 90 inhibitors using virtual co-crystallized pharmacophore generation
Mahmoud A. Al-Sha'er, Iman Mansi, Malak Khanfar & Alaa Abudayyh
Pages: 64-77
Published online: 28 Aug 2016
AbstractforDiscovery of new heat shock protein 90 inhibitors using virtual co-crystallized pharmacophore generation | Full Text | References | PDF (3.4 MB) | Supplemental
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Original Article

Article
Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR
Giannamaria Annunziato, Marco Pieroni, Roberto Benoni, Barbara Campanini, Thelma A. Pertinhez, Chiara Pecchini, Agostino Bruno, Joana Magalhães, Stefano Bettati, Nina Franko, Andrea Mozzarelli & Gabriele Costantino
Pages: 78-87
Published online: 31 Aug 2016
AbstractforCyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR | Full Text | References | PDF (1.2 MB)
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Research Article

Article
Metal-based ethanolamine-derived compounds: a note on their synthesis, characterization and bioactivity
Muhammad Amjad, Sajjad H. Sumrra, Muhammad Safwan Akram & Zahid H. Chohan
Pages: 88-97
Published online: 24 Aug 2016
AbstractforMetal-based ethanolamine-derived compounds: a note on their synthesis, characterization and bioactivity | Full Text | References | PDF (861.9 KB)
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Article
2-Arylbenzo[b]furan derivatives as potent human lipoxygenase inhibitors
Li Lang, Ningning Dong, Deyan Wu, Xue Yao, Weiqiang Lu, Chen Zhang, Ping Ouyang, Jin Zhu, Yun Tang, Wei Wang, Jian Li & Jin Huang
Pages: 98-105
Published online: 02 Sep 2016
Abstractfor2-Arylbenzo[b]furan derivatives as potent human lipoxygenase inhibitors | Full Text | References | PDF (1 MB) | Supplemental
  • 1418 Views
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Article
New N,N-dimethylcarbamate inhibitors of acetylcholinesterase: design synthesis and biological evaluation
Daniela De Vita, Fabiana Pandolfi, Luigi Ornano, Marta Feroci, Isabella Chiarotto, Ilaria Sileno, Federico Pepi, Roberta Costi, Roberto Di Santo & Luigi Scipione
Pages: 106-113
Published online: 03 Sep 2016
AbstractforNew N,N-dimethylcarbamate inhibitors of acetylcholinesterase: design synthesis and biological evaluation | Full Text | References | PDF (553.3 KB)
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Article
A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury
Fazile Nur Ekinci Akdemir, İlhami Gülçin, Berna Karagöz, Recep Soslu & Saleh H. Alwasel
Pages: 114-118
Published online: 23 Aug 2016
AbstractforA comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury | Full Text | References | PDF (393.2 KB)
  • 2084 Views
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Article
Investigation of the inhibitory properties of some phenolic standards and bee products against human carbonic anhydrase I and II
Imdat Aygul, Fatma Yaylaci Karahalil & Claudiu T. Supuran
Pages: 119-124
Published online: 25 Aug 2016
AbstractforInvestigation of the inhibitory properties of some phenolic standards and bee products against human carbonic anhydrase I and II | Full Text | References | PDF (418.6 KB)
  • 1373 Views
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Article
Synthesis and bioactivities of halogen bearing phenolic chalcones and their corresponding bis Mannich bases
Cem Yamali, Halise Inci Gul, Hiroshi Sakagami & Claudiu T. Supuran
Pages: 125-131
Published online: 04 Sep 2016
AbstractforSynthesis and bioactivities of halogen bearing phenolic chalcones and their corresponding bis Mannich bases | Full Text | References | PDF (206.2 KB)
  • 1993 Views
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Article
Inhibition of Bacillus anthracis metallo-β-lactamase by compounds with hydroxamic acid functionality
Sung-Kun Kim, Mara Demuth, Sara R. Schlesinger, Sung Joon Kim, Jonathan Urbanczyk, Robert W. Shaw & Hyunshun Shin
Pages: 132-137
Published online: 25 Aug 2016
AbstractforInhibition of Bacillus anthracis metallo-β-lactamase by compounds with hydroxamic acid functionality | Full Text | References | PDF (604.8 KB) | Supplemental
  • 1397 Views
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Article
Lipid lowering activity of novel N-(benzoylphenyl)pyridine-3-carboxamide derivatives in Triton WR-1339-induced hyperlipidemic rats
Rana Abu Farha, Yasser Bustanji, Yusuf Al-Hiari, Tariq Al-Qirim, Ghassan Abu Shiekha & Rabab Albashiti
Pages: 138-144
Published online: 25 Aug 2016
AbstractforLipid lowering activity of novel N-(benzoylphenyl)pyridine-3-carboxamide derivatives in Triton WR-1339-induced hyperlipidemic rats | Full Text | References | PDF (265.4 KB)
  • 1144 Views
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Article
Synthesis, antitumor screening and cell cycle analysis of novel benzothieno[3,2-b]pyran derivatives
Ashraf F. Zaher, Suzan M. Abuel-Maaty, Hala B. El-Nassan, Samir A.S. Amer & Tamer M. Abdelghany
Pages: 145-153
Published online: 02 Sep 2016
AbstractforSynthesis, antitumor screening and cell cycle analysis of novel benzothieno[3,2-b]pyran derivatives | Full Text | References | PDF (816.2 KB) | Supplemental
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Original Article

Article
Study of the antioxidant activity of Thymus sibthorpii Bentham (Lamiaceae)
Christos Kontogiorgis, Maria Ntella, Lina Mpompou, Fotini Karallaki, Papadopoulos Athanasios, Dimitra Hadjipavlou-Litina & Diamanto Lazari
Pages: 154-159
Published online: 09 Sep 2016
AbstractforStudy of the antioxidant activity of Thymus sibthorpii Bentham (Lamiaceae) | Full Text | References | PDF (235.5 KB) | Supplemental
  • 1456 Views
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Research Article

Article
Design, synthesis and evaluation of 3-quinoline carboxylic acids as new inhibitors of protein kinase CK2
Anatolii R. Syniugin, Olga V. Ostrynska, Maksym O. Chekanov, Galyna P. Volynets, Sergiy A. Starosyla, Volodymyr G. Bdzhola & Sergiy M. Yarmoluk
Pages: 160-169
Published online: 02 Sep 2016
AbstractforDesign, synthesis and evaluation of 3-quinoline carboxylic acids as new inhibitors of protein kinase CK2 | Full Text | References | PDF (1.2 MB)
  • 2845 Views
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Article
Furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site
Tiziana Masini, Barbara Birkaya, Simon van Dijk, Milon Mondal, Johan Hekelaar, Manuel Jäger, Anke C. Terwisscha van Scheltinga, Mulchand S. Patel, Anna K. H. Hirsch & Edelmiro Moman
Pages: 170-175
Published online: 19 Jul 2016
AbstractforFuroates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site | Full Text | References | PDF (357.9 KB) | Supplemental
  • 1187 Views
  • 4 CrossRef citations
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Review Article

Review
Identification and inhibition of carbonic anhydrases from nematodes
Reza Zolfaghari Emameh, Harlan R. Barker, Leo Syrjänen, Linda Urbański, Claudiu T. Supuran & Seppo Parkkila
Pages: 176-184
Published online: 25 Aug 2016
AbstractforIdentification and inhibition of carbonic anhydrases from nematodes | Full Text | References | PDF (2.9 MB)
  • 1366 Views
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Review
Multicomponent chemistry in the synthesis of carbonic anhydrase inhibitors
Stanislav Kalinin, Claudiu T. Supuran & Mikhail Krasavin
Pages: 185-199
Published online: 26 Oct 2016
AbstractforMulticomponent chemistry in the synthesis of carbonic anhydrase inhibitors | Full Text | References | PDF (2.4 MB)
  • 1587 Views
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Short Communication

Rapid Communication
Enzymatic assays and molecular modeling studies of Schisandra chinensis lignans and phenolics from fruit and leaf extracts
Andrei Mocan, Gokhan Zengin, Gianina Crişan & Adriano Mollica
Pages: 200-210
Published online: 05 Sep 2016
AbstractforEnzymatic assays and molecular modeling studies of Schisandra chinensis lignans and phenolics from fruit and leaf extracts | Full Text | References | PDF (3.1 MB) | Supplemental
  • 2303 Views
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Erratum

Correction
Correction to: Discovery of new heat shock protein 90 inhibitors using virtual co-crystallized pharmacophore generation
Page: x
Published online: 15 Dec 2016
CitationforCorrection to: Discovery of new heat shock protein 90 inhibitors using virtual co-crystallized pharmacophore generation | Full Text | PDF (104.4 KB)
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