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Review Articles

Routes and mechanisms of extracellular vesicle uptake

, &
Article: 24641 | Received 14 Apr 2014, Accepted 03 Jul 2014, Published online: 04 Aug 2014

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Zaijun Zou, Han Li, Gang Xu, Yunxiang Hu, Weiguo Zhang & Kang Tian. (2023) Current Knowledge and Future Perspectives of Exosomes as Nanocarriers in Diagnosis and Treatment of Diseases. International Journal of Nanomedicine 18, pages 4751-4778.
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Yiming Zhang, Yiming Dou, Yang Liu, Mingyuan Di, Hanming Bian, Xun Sun & Qiang Yang. (2023) Advances in Therapeutic Applications of Extracellular Vesicles. International Journal of Nanomedicine 18, pages 3285-3307.
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Yu-Guo Yuan, Jia-Lin Wang, Ya-Xin Zhang, Ling Li, Abu Musa Md Talimur Reza & Sangiliyandi Gurunathan. (2023) Biogenesis, Composition and Potential Therapeutic Applications of Mesenchymal Stem Cells Derived Exosomes in Various Diseases. International Journal of Nanomedicine 18, pages 3177-3210.
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Jing Zhang, Haijing Song, Yanan Dong, Ganghui Li, Jun Li, Qizhe Cai, Shoujun Yuan, Yi Wang & Haifeng Song. (2023) Surface Engineering of HEK293 Cell-Derived Extracellular Vesicles for Improved Pharmacokinetic Profile and Targeted Delivery of IL-12 for the Treatment of Hepatocellular Carcinoma. International Journal of Nanomedicine 18, pages 209-223.
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Xiaofei Zhou, Yuetang Zhuang, Xiaohong Liu, Yaowen Gu, Junting Wang, Yuchen Shi, Li Zhang, Rui Li, Yelin Zhao, Hebing Chen, Jiao Li, Hongjuan Yao & Liang Li. (2023) Study on tumour cell-derived hybrid exosomes as dasatinib nanocarriers for pancreatic cancer therapy. Artificial Cells, Nanomedicine, and Biotechnology 51:1, pages 532-546.
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Yu-Wen Wu, Deng-Yao Lee, Yeh-Lin Lu, Liling Delila, Ouada Nebie, Lassina Barro, Chun Austin Changou, Long-Sheng Lu, Hadi Goubran & Thierry Burnouf. (2023) Platelet extracellular vesicles are efficient delivery vehicles of doxorubicin, an anti-cancer drug: preparation and in vitro characterization. Platelets 34:1.
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Jiaxin Wang, Yiying Tao, Fan Zhao, Tong Liu, Xiahong Shen & Ling Zhou. (2023) Expression of urinary exosomal miRNA-615-3p and miRNA-3147 in diabetic kidney disease and their association with inflammation and fibrosis. Renal Failure 45:1.
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Laura Patras, Aura Elena Ionescu, Cristian Munteanu, Renata Hajdu, Andreea Kosa, Alina Porfire, Emilia Licarete, Valentin Florian Rauca, Alina Sesarman, Lavinia Luput, Paul Bulzu, Paul Chiroi, Rares Andrei Tranca, Marta-Szilvia Meszaros, Giorgiana Negrea, Lucian Barbu-Tudoran, Monica Potara, Stefan Szedlacsek & Manuela Banciu. (2022) Trojan horse treatment based on PEG-coated extracellular vesicles to deliver doxorubicin to melanoma in vitro and in vivo. Cancer Biology & Therapy 23:1, pages 1-16.
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Manling Wu, Min Wang, Haoyuan Jia & Peipei Wu. (2022) Extracellular vesicles: emerging anti-cancer drugs and advanced functionalization platforms for cancer therapy. Drug Delivery 29:1, pages 2513-2538.
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Huizhen Li, Wan Xu, Fang Li, Ru Zeng, Xiuming Zhang, Xianwu Wang, Shaojun Zhao, Jian Weng, Zhu Li & Liping Sun. (2022) Amplification of anticancer efficacy by co-delivery of doxorubicin and lonidamine with extracellular vesicles. Drug Delivery 29:1, pages 192-202.
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Gauresh G. Shivji, Rajib Dhar & Arikketh Devi. (2022) Role of exosomes and its emerging therapeutic applications in the pathophysiology of non-infectious diseases. Biomarkers 27:6, pages 534-548.
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Fujiang Li, Xin Chen, Cong Shang, Qinglong Ying, Xianjun Zhou, Rongkun Zhu, Hongting Lu, Xiwei Hao, Qian Dong & Zhong Jiang. (2021) Bone Marrow Mesenchymal Stem Cells-Derived Extracellular Vesicles Promote Proliferation, Invasion and Migration of Osteosarcoma Cells via the lncRNA MALAT1/miR-143/NRSN2/Wnt/β-Catenin Axis. OncoTargets and Therapy 14, pages 737-749.
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Sangiliyandi Gurunathan, Min-Hee Kang & Jin-Hoi Kim. (2021) A Comprehensive Review on Factors Influences Biogenesis, Functions, Therapeutic and Clinical Implications of Exosomes. International Journal of Nanomedicine 16, pages 1281-1312.
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Saray Tabak, Sofia Schreiber-Avissar & Elie Beit-Yannai. (2021) Influence of Anti-Glaucoma Drugs on Uptake of Extracellular Vesicles by Trabecular Meshwork Cells. International Journal of Nanomedicine 16, pages 1067-1081.
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Sudarshan Mahala, Sweta Rai, Akansha Singh, Arnav Mehrotra, Hari Om Pandey & Amit Kumar. (2021) Perspectives of bovine and human milk exosomics as health biomarkers for advancing systemic therapeutic potential. Food Biotechnology 35:4, pages 273-309.
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Jia Liu, Feng Jiang, Yu Jiang, Yicheng Wang, Zelin Li, Xuefeng Shi, Yanping Zhu, Hongbo Wang & Zhuhong Zhang. (2020) Roles of Exosomes in Ocular Diseases. International Journal of Nanomedicine 15, pages 10519-10538.
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Siyuan Chen, Xiaodong Zhu & Shenglin Huang. (2020) Clinical applications of extracellular vesicle long RNAs. Critical Reviews in Clinical Laboratory Sciences 57:8, pages 508-521.
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Yoichiro Yoshida, Tsunehisa Nagamori, Emi Ishibazawa, Hiroya Kobayashi, Tomoko Kure, Hiromi Sakai, Daisuke Takahashi, Mitsuhiro Fujihara & Hiroshi Azuma. (2020) Contribution of long-chain fatty acid to induction of myeloid-derived suppressor cell (MDSC)-like cells – induction of MDSC by lipid vesicles (liposome). Immunopharmacology and Immunotoxicology 42:6, pages 614-624.
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Xiaohui Zhang, Li Liu, Meiling Tang, Hong Li, Xiaoqing Guo & Xiaoqian Yang. (2020) The effects of umbilical cord-derived macrophage exosomes loaded with cisplatin on the growth and drug resistance of ovarian cancer cells. Drug Development and Industrial Pharmacy 46:7, pages 1150-1162.
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Stéphanie Alkoussa, Sébastien Hulo, Dominique Courcot, Sylvain Billet & Perrine J. Martin. (2020) Extracellular vesicles as actors in the air pollution related cardiopulmonary diseases. Critical Reviews in Toxicology 50:5, pages 402-423.
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Hui Li, Itziar Pinilla-Macua, Yingshi Ouyang, Elena Sadovsky, Kazuhiro Kajiwara, Alexander Sorkin & Yoel Sadovsky. (2020) Internalization of trophoblastic small extracellular vesicles and detection of their miRNA cargo in P-bodies. Journal of Extracellular Vesicles 9:1.
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Santra Brenna, Hermann C. Altmeppen, Behnam Mohammadi, Björn Rissiek, Florence Schlink, Peter Ludewig, Christoph Krisp, Hartmut Schlüter, Antonio Virgilio Failla, Carola Schneider, Markus Glatzel, Berta Puig & Tim Magnus. (2020) Characterization of brain-derived extracellular vesicles reveals changes in cellular origin after stroke and enrichment of the prion protein with a potential role in cellular uptake. Journal of Extracellular Vesicles 9:1.
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Mahmoud Elashiry, Mohamed M. Elashiry, Ranya Elsayed, Mythily Rajendran, Carol Auersvald, Rana Zeitoun, Mohammad H. Rashid, Roxan Ara, Mohamed M. Meghil, Yutao Liu, Ali S. Arbab, Roger M. Arce, Mark Hamrick, Mohammed Elsalanty, Marshall Brendan, Rafal Pacholczyk & Christopher W. Cutler. (2020) Dendritic cell derived exosomes loaded with immunoregulatory cargo reprogram local immune responses and inhibit degenerative bone disease in vivo. Journal of Extracellular Vesicles 9:1.
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Lizhou Xu, Farid N. Faruqu, Revadee Liam-or, Omar Abu Abed, Danyang Li, Kerrie Venner, Rachel J Errington, Huw Summers, Julie Tzu-Wen Wang & Khuloud T. Al-Jamal. (2020) Design of experiment (DoE)-driven in vitro and in vivo uptake studies of exosomes for pancreatic cancer delivery enabled by copper-free click chemistry-based labelling. Journal of Extracellular Vesicles 9:1.
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Baishijiao Bian, Congjian Zhao, Xiangyu He, Yu Gong, Chunge Ren, Lingling Ge, Yuxiao Zeng, Qiyou Li, Min Chen, Chuanhuang Weng, Juncai He, Yajie Fang, Haiwei Xu & Zheng Qin Yin. (2020) Exosomes derived from neural progenitor cells preserve photoreceptors during retinal degeneration by inactivating microglia. Journal of Extracellular Vesicles 9:1.
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Heikki Saari, Tiia Turunen, Andres Lõhmus, Mikko Turunen, Matti Jalasvuori, Sarah J. Butcher, Seppo Ylä-Herttuala, Tapani Viitala, Vincenzo Cerullo, Pia R. M. Siljander & Marjo Yliperttula. (2020) Extracellular vesicles provide a capsid-free vector for oncolytic adenoviral DNA delivery. Journal of Extracellular Vesicles 9:1.
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Yang You, Kathleen Borgmann, Venkata Viswanadh Edara, Satomi Stacy, Anuja Ghorpade & Tsuneya Ikezu. (2020) Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing. Journal of Extracellular Vesicles 9:1.
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Ashley E. Russell, Alexandra Sneider, Kenneth W. Witwer, Paolo Bergese, Suvendra N. Bhattacharyya, Alexander Cocks, Emanuele Cocucci, Uta Erdbrügger, Juan M. Falcon-Perez, David W. Freeman, Thomas M. Gallagher, Shuaishuai Hu, Yiyao Huang, Steven M. Jay, Shin-ichi Kano, Gregory Lavieu, Aleksandra Leszczynska, Alicia M. Llorente, Quan Lu, Vasiliki Mahairaki, Dillon C. Muth, Nicole Noren Hooten, Matias Ostrowski, Ilaria Prada, Susmita Sahoo, Tine Hiorth Schøyen, Lifu Sheng, Deanna Tesch, Guillaume Van Niel, Roosmarijn E. Vandenbroucke, Frederik J. Verweij, Ana V. Villar, Marca Wauben, Ann M. Wehman, Hang Yin, David Raul Francisco Carter & Pieter Vader. (2019) Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop. Journal of Extracellular Vesicles 8:1.
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Theresa L. Whiteside. (2019) Human regulatory T cells (Treg) and their response to cancer. Expert Review of Precision Medicine and Drug Development 4:4, pages 215-228.
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Sonja Ludwig, Lukasz Marczak, Priyanka Sharma, Agata Abramowicz, Marta Gawin, Piotr Widlak, Theresa L. Whiteside & Monika Pietrowska. (2019) Proteomes of exosomes from HPV(+) or HPV(-) head and neck cancer cells: differential enrichment in immunoregulatory proteins. OncoImmunology 8:7.
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Ron J. Leavitt, Charles L. Limoli & Janet E. Baulch. (2019) miRNA-based therapeutic potential of stem cell-derived extracellular vesicles: a safe cell-free treatment to ameliorate radiation-induced brain injury. International Journal of Radiation Biology 95:4, pages 427-435.
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Zulfikar Azam, Véronique Quillien, Gang Wang & Shing-Shun Tony To. (2019) The potential diagnostic and prognostic role of extracellular vesicles in glioma: current status and future perspectives. Acta Oncologica 58:3, pages 353-362.
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Banuja Balachandran & Yuana Yuana. (2019) Extracellular vesicles-based drug delivery system for cancer treatment. Cogent Medicine 6:1.
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Zahra Naseri, Reza Kazemi Oskuee, Mahmoud Reza Jaafari & Mehdi Forouzandeh Moghadam. (2018) Exosome-mediated delivery of functionally active miRNA-142-3p inhibitor reduces tumorigenicity of breast cancer in vitro and in vivo. International Journal of Nanomedicine 13, pages 7727-7747.
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Theresa L. Whiteside. (2018) The potential of tumor-derived exosomes for noninvasive cancer monitoring: an update. Expert Review of Molecular Diagnostics 18:12, pages 1029-1040.
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Michiel Pegtel, Hector Peinado, Francesca Perut, Michael W Pfaffl, Donald G Phinney, Bartijn CH Pieters, Ryan C Pink, David S Pisetsky, Elke Pogge von Strandmann, Iva Polakovicova, Ivan KH Poon, Bonita H Powell, Ilaria Prada, Lynn Pulliam, Peter Quesenberry, Annalisa Radeghieri, Robert L Raffai, Stefania Raimondo, Janusz Rak, Marcel I Ramirez, Graça Raposo, Morsi S Rayyan, Neta Regev-Rudzki, Franz L Ricklefs, Paul D Robbins, David D Roberts, Silvia C Rodrigues, Eva Rohde, Sophie Rome, Kasper MA Rouschop, Aurelia Rughetti, Ashley E Russell, Paula Saá, Susmita Sahoo, Edison Salas-Huenuleo, Catherine Sánchez, Julie A Saugstad, Meike J Saul, Raymond M Schiffelers, Raphael Schneider, Tine Hiorth Schøyen, Aaron Scott, Eriomina Shahaj, Shivani Sharma, Olga Shatnyeva, Faezeh Shekari, Ganesh Vilas Shelke, Ashok K Shetty, Kiyotaka Shiba, Pia R-M Siljander, Andreia M Silva, Agata Skowronek, Orman L Snyder$suffix/text()$suffix/text(), Rodrigo Pedro Soares, Barbara W Sódar, Carolina Soekmadji, Javier Sotillo, Philip D Stahl, Willem Stoorvogel, Shannon L Stott, Erwin F Strasser, Simon Swift, Hidetoshi Tahara, Muneesh Tewari, Kate Timms, Swasti Tiwari, Rochelle Tixeira, Mercedes Tkach, Wei Seong Toh, Richard Tomasini, Ana Claudia Torrecilhas, Juan Pablo Tosar, Vasilis Toxavidis, Lorena Urbanelli, Pieter Vader, Bas WM van Balkom, Susanne G van der Grein, Jan Van Deun, Martijn JC van Herwijnen, Kendall Van Keuren-Jensen, Guillaume van Niel, Martin E van Royen, Andre J van Wijnen, M Helena Vasconcelos, Ivan J Vechetti$suffix/text()$suffix/text(), Tiago D Veit, Laura J Vella, Émilie Velot, Frederik J Verweij, Beate Vestad, Jose L Viñas, Tamás Visnovitz, Krisztina V Vukman, Jessica Wahlgren, Dionysios C Watson, Marca HM Wauben, Alissa Weaver, Jason P Webber, Viktoria Weber, Ann M Wehman, Daniel J Weiss, Joshua A Welsh, Sebastian Wendt, Asa M Wheelock, Zoltán Wiener, Leonie Witte, Joy Wolfram, Angeliki Xagorari, Patricia Xander, Jing Xu, Xiaomei Yan, María Yáñez-Mó, Hang Yin, Yuana Yuana, Valentina Zappulli, Jana Zarubova, Vytautas Žėkas, Jian-ye Zhang, Zezhou Zhao, Lei Zheng, Alexander R Zheutlin, Antje M Zickler, Pascale Zimmermann, Angela M Zivkovic, Davide Zocco & Ewa K Zuba-Surma. (2018) Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. Journal of Extracellular Vesicles 7:1.
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Laurent Muller, Patricia Simms, Chang-Sook Hong, Michael I. Nishimura, Edwin K. Jackson, Simon C. Watkins & Theresa L. Whiteside. (2017) Human tumor-derived exosomes (TEX) regulate Treg functions via cell surface signaling rather than uptake mechanisms. OncoImmunology 6:8.
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Lucia E. Rosas, Ola A. Elgamal, Xiaokui Mo, Mitch A. Phelps, Thomas D. Schmittgen & Tracey L. Papenfuss. (2016) In vitro immunotoxicity assessment of culture-derived extracellular vesicles in human monocytes. Journal of Immunotoxicology 13:5, pages 652-665.
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Michael Boyiadzis & Theresa L. Whiteside. (2016) Plasma-derived exosomes in acute myeloid leukemia for detection of minimal residual disease: are we ready?. Expert Review of Molecular Diagnostics 16:6, pages 623-629.
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Oscar A. Tovar-Camargo, Shusuke Toden & Ajay Goel. (2016) Exosomal microRNA Biomarkers: Emerging Frontiers in Colorectal and Other Human Cancers. Expert Review of Molecular Diagnostics 16:5, pages 553-567.
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Katie Meehan & Laura J Vella. (2016) The contribution of tumour-derived exosomes to the hallmarks of cancer. Critical Reviews in Clinical Laboratory Sciences 53:2, pages 121-131.
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Tania Martins-Marques, Maria Joao Pinho, Monica Zuzarte, Carla Oliveira, Paulo Pereira, Joost P. G. Sluijter, Celia Gomes & Henrique Girao. (2016) Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin. Journal of Extracellular Vesicles 5:1.
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Sander A. A. Kooijmans, Clara Gómez Aleza, Steve R. Roffler, Wouter W. van Solinge, Pieter Vader & Raymond M. Schiffelers. (2016) Display of GPI-anchored anti-EGFR nanobodies on extracellular vesicles promotes tumour cell targeting. Journal of Extracellular Vesicles 5:1.
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Fabio Simbari, Jana McCaskill, Gillian Coakley, Marissa Millar, Rick M. Maizels, Gemma Fabriás, Josefina Casas & Amy H. Buck. (2016) Plasmalogen enrichment in exosomes secreted by a nematode parasite versus those derived from its mouse host: implications for exosome stability and biology. Journal of Extracellular Vesicles 5:1.
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Nina Koliha, Yvonne Wiencek, Ute Heider, Christian Jüngst, Nikolay Kladt, Susanne Krauthäuser, Ian C. D. Johnston, Andreas Bosio, Astrid Schauss & Stefan Wild. (2016) A novel multiplex bead-based platform highlights the diversity of extracellular vesicles. Journal of Extracellular Vesicles 5:1.
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Theresa L Whiteside. (2015) The potential of tumor-derived exosomes for noninvasive cancer monitoring. Expert Review of Molecular Diagnostics 15:10, pages 1293-1310.
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Cecilia Lässer. (2015) Exosomes in diagnostic and therapeutic applications: biomarker, vaccine and RNA interference delivery vehicle. Expert Opinion on Biological Therapy 15:1, pages 103-117.
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Erez Eitan, Shi Zhang, Kenneth W. Witwer & Mark P. Mattson. (2015) Extracellular vesicle–depleted fetal bovine and human sera have reduced capacity to support cell growth. Journal of Extracellular Vesicles 4:1.
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Yasunari Matsuzaka & Ryu Yashiro. Immunological Regulation of Gut-Tropic Immune Cells by Extracellular Vesicles. Immunological Investigations 0:0, pages 1-30.
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Articles from other publishers (1507)

Shi Hu, Rui Hao, Zitong Yu, Huitao Zhang & Hui Yang. (2024) Highly efficient labelling of extracellular vesicles for enhanced detection on a microfluidic platform. Chinese Chemical Letters 35:2, pages 108534.
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Abeer Ahmed Qaed Ahmed & Tracey Jill Morton McKay. (2024) Environmental and ecological importance of bacterial extracellular vesicles (BEVs). Science of The Total Environment 907, pages 168098.
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Mingming Ning, Shanshan Hua, Ying Ma, Yunpeng Liu, Dianliang Wang, Kai Xu & Haijia Yu. (2024) Microvesicles facilitate the differentiation of mesenchymal stem cells into pancreatic beta-like cells via miR-181a-5p/150-5p. International Journal of Biological Macromolecules 254, pages 127719.
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Huanyu Luo, Anahid Ahmadi Birjandi, Feilong Ren, Tianmeng Sun, Paul T. Sharpe, Hongchen Sun & Zhengwen An. (2024) Advances in oral mesenchymal stem cell-derived extracellular vesicles in health and disease. Genes & Diseases 11:1, pages 346-357.
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V. S. B. Wies Mancini, V. S. Mattera, J. M. Pasquini, L. A. Pasquini & J. D. Correale. (2023) Microglia‐derived extracellular vesicles in homeostasis and demyelination/remyelination processes. Journal of Neurochemistry.
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Cristina Grange, Alessia Dalmasso, Judiel John Cortez, Beatrice Spokeviciute & Benedetta Bussolati. (2023) Exploring the role of urinary extracellular vesicles in kidney physiology, aging, and disease progression. American Journal of Physiology-Cell Physiology 325:6, pages C1439-C1450.
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Deepika Yadav & Rishabha Malviya. (2023) Exploring potential of exosomes drug delivery system in the treatment of cancer: Advances and prospective. Medicine in Drug Discovery 20, pages 100163.
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Carolina Paba, Virginia Dorigo, Beatrice Senigagliesi, Nicolò Tormena, Pietro Parisse, Kislon Voitchovsky & Loredana Casalis. (2023) Lipid bilayer fluidity and degree of order regulates small EVs adsorption on model cell membrane. Journal of Colloid and Interface Science 652, pages 1937-1943.
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Sreevatsa Vemuri, Mahavir Singh, Rubens P. Homme & Suresh C. Tyagi. (2023) Interoception, heart failure and exosomal cargo as potential biomarkers. Gene Reports 33, pages 101849.
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Yi Xu, Yue Yao, Liang Yu, Hiu Ling Fung, Alexander Hin Ning Tang, Irene Oi-Lin Ng, Melody Y. M. Wong, Chi-Ming Che, Jing Ping Yun, Yunfu Cui & Judy Wai Ping Yam. (2023) Clathrin light chain A facilitates small extracellular vesicle uptake to promote hepatocellular carcinoma progression. Hepatology International 17:6, pages 1490-1499.
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Tünde Szatmári, Katalin Balázs, Ilona Barbara Csordás, Géza Sáfrány & Katalin Lumniczky. (2023) Effect of radiotherapy on the DNA cargo and cellular uptake mechanisms of extracellular vesicles. Strahlentherapie und Onkologie 199:12, pages 1191-1213.
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Janusz Rak & Leon Strzadala. (2023) Heterogeneity of Extracellular Vesicles and Particles: Molecular Voxels in the Blood Borne “Hologram” of Organ Function, Dysfunction and Cancer. Archivum Immunologiae et Therapiae Experimentalis 71:1.
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Yu‐Long Lan, Shuang Zou, Wen Wang, Qi Chen & Yongjian Zhu. (2023) Progress in cancer neuroscience. MedComm 4:6.
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Wenxiu Han, Hailiang Zhang, Lei Feng, Ruili Dang, Jing Wang, Changmeng Cui & Pei Jiang. (2023) The emerging role of exosomes in communication between the periphery and the central nervous system. MedComm 4:6.
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Kinga Dóra Kovács, Tamás Visnovitz, Tamás Gerecsei, Beatrix Peter, Sándor Kurunczi, Anna Koncz, Krisztina Németh, Dorina Lenzinger, Krisztina V. Vukman, Anna Balogh, Imola Rajmon, Péter Lőrincz, Inna Székács, Edit I. Buzás & Robert Horvath. (2023) Nanoinjection of extracellular vesicles to single live cells by robotic fluidic force microscopy. Journal of Extracellular Vesicles 12:12.
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Luisa Loconte, Davinia Arguedas, Rojbin El, Alix Zhou, Anna Chipont, Lea Guyonnet, Coralie Guerin, Ester Piovesana, José Luis Vázquez‐Ibar, Alain Joliot, Clotilde Théry & Lorena Martín‐Jaular. (2023) Detection of the interactions of tumour derived extracellular vesicles with immune cells is dependent on EV‐labelling methods. Journal of Extracellular Vesicles 12:12.
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D. Subha, R. AnuKiruthika, Harsha Sreeraj & K. S. Tamilselvi. (2023) Plant exosomes: nano conveyors of pathogen resistance. Discover Nano 18:1.
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Tingjun Cheng, Benson K. Kosgei, Geofrey F. Soko, Stephene S. Meena, Tong Li, Qianan Cao, Zhe Zhao, Samuel K. S. Cheng, Qingjun Liu, Fang Wang, Genhua Zhu & Ray P. S. Han. (2023) Using Functionalized Liposomes to Harvest Extracellular Vesicles of Similar Characteristics in Dermal Interstitial Fluid. Analytical Chemistry.
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Hongyu Li, Yunhuan Zhu, Xin Wang, Yilu Feng, Yuncheng Qian, Qiman Ma, Xinyuan Li, Yihan Chen & Keda Chen. (2023) Joining Forces: The Combined Application of Therapeutic Viruses and Nanomaterials in Cancer Therapy. Molecules 28:22, pages 7679.
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Simon Park, Jaesung Lim, Seulgi Kim, Minha Jeon, Hwira Baek, Wooram Park, Juwon Park, Se−Na Kim, Nae-Gyu Kang, Chun Gwon Park & Jin Woong Kim. (2023) Anti-Inflammatory Artificial Extracellular Vesicles with Notable Inhibition of Particulate Matter-Induced Skin Inflammation and Barrier Function Impairment. ACS Applied Materials & Interfaces.
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Siming Yu, Ran Liao, Lu Bai, Madi Guo, Yu Zhang, Yumin Zhang, Qi Yang, Yushuai Song, Zhiwei Li, Qingwei Meng, Shubin Wang & Xiaoyi Huang. (2023) Anticancer effect of hUC-MSC-derived exosome-mediated delivery of PMO-miR-146b-5p in colorectal cancer. Drug Delivery and Translational Research.
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Burcak Yavuz, Asli Pinar Zorba Yildiz, Emrah Sefik Abamor, Hakan Darici & Adil M. Allahverdiyev. (2023) Neuroprotective Effects of Wharton Jelly Stem Cell-Derived Exosomes Developed as Nano-Drug Delivery System in 6-OHDA-Induced Neurotoxicity in 2D and 3D Neuronal Cell Line. Regenerative Engineering and Translational Medicine.
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Francisco Sierra-López, Ismael Castelan-Ramírez, Dolores Hernández-Martínez, Lizbeth Salazar-Villatoro, David Segura-Cobos, Catalina Flores-Maldonado, Verónica Ivonne Hernández-Ramírez, Tomás Ernesto Villamar-Duque, Adolfo René Méndez-Cruz, Patricia Talamás-Rohana & Maritza Omaña-Molina. (2023) Extracellular Vesicles Secreted by Acanthamoeba culbertsoni Have COX and Proteolytic Activity and Induce Hemolysis. Microorganisms 11:11, pages 2762.
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Giada Rosso & Valentina Cauda. (2022) Biomimicking Extracellular Vesicles with Fully Artificial Ones: A Rational Design of EV-BIOMIMETICS toward Effective Theranostic Tools in Nanomedicine. ACS Biomaterials Science & Engineering 9:11, pages 5924-5932.
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Xiaoyan Zhang, Shengjie Sun, Gang Ren, Wujun Liu & Hong Chen. (2023) Advances in Intercellular Communication Mediated by Exosomal ncRNAs in Cardiovascular Disease. International Journal of Molecular Sciences 24:22, pages 16197.
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Afruja Khan, Avijit Sardar, Pradip K. Tarafdar & Amirul I. Mallick. (2023) Heterogeneity and Compositional Diversities of Campylobacter jejuni Outer Membrane Vesicles (OMVs) Drive Multiple Cellular Uptake Processes . ACS Infectious Diseases 9:11, pages 2325-2339.
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Zhizhen He, Johannes Greven, Yulong Shi, Kang Qin, Qun Zhao, Xing Zhang, Eva Miriam Buhl, Jörg Eschweiler, Frank Hildebrand & Elizabeth Rosado Balmayor. (2023) Extracellular vesicles derived from endothelial cells modulate macrophage phenotype in vitro. European Journal of Medical Research 28:1.
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Li Wang, Xin Yu, Juan Zhou & Chunxia Su. (2023) Extracellular Vesicles for Drug Delivery in Cancer Treatment. Biological Procedures Online 25:1.
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Daniel Phillips & Denis Noble. (2023) Bubbling beyond the barrier: exosomal RNA as a vehicle for soma–germline communication. The Journal of Physiology.
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Xiaohui Zhang, Jiapo Wang, Na Liu, Weimin Wu, Hong Li, Wen Lu & Xiaoqing Guo. (2023) Umbilical Cord Blood-Derived M1 Macrophage Exosomes Loaded with Cisplatin Target Ovarian Cancer In Vivo and Reverse Cisplatin Resistance . Molecular Pharmaceutics 20:11, pages 5440-5453.
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Mingxiang Cai, Huizhen Peng, Minyi Liu, Maohua Huang, Wen Zheng, Guilan Zhang, Wenjia Lai, Chufang Liao, Lizhao Cai, Dongmei Zhang & Xiangning Liu. (2023) Vascular Pericyte-Derived Exosomes Inhibit Bone Resorption via Traf3. International Journal of Nanomedicine Volume 18, pages 7065-7077.
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Iman Owliaee, Mehran khaledian, Armin Khaghani Boroujeni & Ali Shojaeian. (2023) Engineered small extracellular vesicles as a novel platform to suppress human oncovirus-associated cancers. Infectious Agents and Cancer 18:1.
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Felix Osten, Wolfgang Löscher & Birthe Gericke. (2023) Human brain microvascular endothelial cells release different types of P-glycoprotein-containing extracellular vesicles upon exposure to doxorubicin. Toxicology and Applied Pharmacology 479, pages 116712.
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Alireza Soleimani Mamalo, Vahid Alivirdiloo, Azadeh Sadeghnejad, Mobasher Hajiabbasi, Morad Kohandel Gargari & Mohammad Valilo. (2023) Potential roles of the exosome/microRNA axis in breast cancer. Pathology - Research and Practice 251, pages 154845.
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Andrea Ridolfi, Jacopo Cardellini, Fatlinda Gashi, Martijn J.C. van Herwijnen, Martin Trulsson, José Campos-Terán, Marca H. M. Wauben, Debora Berti, Tommy Nylander & Joakim Stenhammar. (2023) Electrostatic interactions control the adsorption of extracellular vesicles onto supported lipid bilayers. Journal of Colloid and Interface Science 650, pages 883-891.
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Ivana Jarak, Ana Isabel Santos, Ana Helena Pinto, Cátia Domingues, Inês Silva, Raquel Melo, Francisco Veiga & Ana Figueiras. (2023) Colorectal cancer cell exosome and cytoplasmic membrane for homotypic delivery of therapeutic molecules. International Journal of Pharmaceutics 646, pages 123456.
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Bao-Hong Lee, You-Zuo Chen, Tang-Long Shen, Tzu-Ming Pan & Wei-Hsuan Hsu. (2023) Proteomic characterization of extracellular vesicles derived from lactic acid bacteria. Food Chemistry 427, pages 136685.
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Yousheng Wu, Xiaoxiong Huang, Zefeng Tan, Jiankun Zang, Min Peng, Niu He, Tao Zhang, Hongcheng Mai, Anding Xu & Dan Lu. (2023) FUS-mediated HypEVs: Neuroprotective effects against ischemic stroke. Bioactive Materials 29, pages 196-213.
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Wenhan Wu & Jia He. (2023) Unveiling the functional paradigm of exosome-derived long non-coding RNAs (lncRNAs) in cancer: based on a narrative review and systematic review. Journal of Cancer Research and Clinical Oncology 149:16, pages 15219-15247.
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Kaizhe Wang, Yuhan Wei, Xiaodong Xie, Qian Li, Xiaoguo Liu, Lihua Wang, Jiang Li, Ji Wu & Chunhai Fan. (2023) DNA‐Programmed Stem Cell Niches via Orthogonal Extracellular Vesicle–Cell Communications. Advanced Materials 35:45.
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Qingpeng Xie, Yujia Hao, Na Li, Haoyue Song, Xiaohang Chen, Zilan Zhou, Jia Wang, Yuan Zhang, Huifei Li, Pengcheng Han & Xing Wang. (2023) Cellular Uptake of Engineered Extracellular Vesicles: Biomechanisms, Engineered Strategies, and Disease Treatment. Advanced Healthcare Materials.
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Xiaoyu Zhang, Jing Wang, Jing Zhang, Yuwei Tan, Yiming Li & Zhiyong Peng. (2023) Exosomes Highlight Future Directions in the Treatment of Acute Kidney Injury. International Journal of Molecular Sciences 24:21, pages 15568.
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Israel Martinez-Espinosa, José Antonio Serrato & Blanca Ortiz-Quintero. (2023) The Role of Exosome-Derived microRNA on Lung Cancer Metastasis Progression. Biomolecules 13:11, pages 1574.
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Qiong Meng, Chen Chen, Na Yang, Olesia Gololobova, Changyou Shi, Christopher A. Dunn, Martina Rossi, Jennifer L. Martindale, Nathan Basisty, Jun Ding, Michael Delannoy, Srikanta Basu, Krystyna Mazan-Mamczarz, Chang Hoon Shin, Jen-Hao Yang, Peter F. Johnson, Kenneth W. Witwer, Arya Biragyn, Payel Sen, Kotb Abdelmohsen, Supriyo De & Myriam Gorospe. (2023) Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4. Proceedings of the National Academy of Sciences 120:43.
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Jae Yeong Ha, Jiwon Seok, Suk-Jeong Kim, Hye-Jin Jung, Ka-Young Ryu, Michiko Nakamura, Il-Sung Jang, Su-Hyung Hong, Youngkyun Lee & Heon-Jin Lee. (2023) Periodontitis promotes bacterial extracellular vesicle-induced neuroinflammation in the brain and trigeminal ganglion. PLOS Pathogens 19:10, pages e1011743.
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Vanesa Mattera, Federico Occhiuzzi, Jorge Correale & Juana M. Pasquini. (2023) Remyelinating effect driven by transferrin‐loaded extracellular vesicles. Glia.
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Shiqi Yang, Zhaolin Zeng, Qing Yuan, Qian Chen, Zuo Wang, Hui Xie & Jianghua Liu. (2023) Vascular calcification: from the perspective of crosstalk. Molecular Biomedicine 4:1.
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Aleksandra Leszczynska, Christian Stoess, Hana Sung, Davide Povero, Akiko Eguchi & Ariel Feldstein. (2023) Extracellular Vesicles as Therapeutic and Diagnostic Tools for Chronic Liver Diseases. Biomedicines 11:10, pages 2808.
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Han Gao, Shiqi Wang, Zehua Liu, Jouni T. Hirvonen & Hélder A. Santos. (2023) Mycophenolic Acid-loaded Naïve Macrophage-derived Extracellular Vesicles Rescue Cardiac Myoblast after Inflammatory Injury. ACS Applied Bio Materials 6:10, pages 4269-4276.
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Chao-Fu Yang, Chun-Che Liao, Hung-Wei Hsu, Jian-Jong Liang, Chih-Shin Chang, Hui-Ying Ko, Rue-Hsin Chang, Wei-Chun Tang, Ming-Hao Chang, I-Hsuan Wang & Yi-Ling Lin. (2023) Human ACE2 protein is a molecular switch controlling the mode of SARS-CoV-2 transmission. Journal of Biomedical Science 30:1.
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Kuei-Hsiang Pan, Hung Chang & Wei Yuan Yang. (2023) Extracellular release in the quality control of the mammalian mitochondria. Journal of Biomedical Science 30:1.
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Weikai Lin, Jianjun Fang, Shibo Wei, Guangpeng He, Jiaxing Liu, Xian Li, Xueqiang Peng, Dai Li, Shuo Yang, Xinyu Li, Liang Yang & Hangyu Li. (2023) Extracellular vesicle-cell adhesion molecules in tumours: biofunctions and clinical applications. Cell Communication and Signaling 21:1.
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Łukasz Skoczylas, Marta Gawin, Daniel Fochtman, Piotr Widłak, Theresa L. Whiteside & Monika Pietrowska. (2023) Immune capture and protein profiling of small extracellular vesicles from human plasma. PROTEOMICS.
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Xiao Rong, Yuanjiao Tang, Sujiao Cao, Sutong Xiao, Haonan Wang, Bihui Zhu, Songya Huang, Mohsen Adeli, Raul D. Rodriguez, Chong Cheng, Lang Ma & Li Qiu. (2023) An Extracellular Vesicle-Cloaked Multifaceted Biocatalyst for Ultrasound-Augmented Tendon Matrix Reconstruction and Immune Microenvironment Regulation. ACS Nano 17:17, pages 16501-16516.
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Maurizio Bruschi, Giovanni Candiano, Andrea Angeletti, Francesca Lugani & Isabella Panfoli. (2023) Extracellular Vesicles as Source of Biomarkers in Glomerulonephritis. International Journal of Molecular Sciences 24:18, pages 13894.
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Andrea Fracchia, Drirh Khare, Samar Da’na, Reuven Or, Amnon Buxboim, Boaz Nachmias, Claudine Barkatz, Regina Golan-Gerstl, Swasti Tiwari, Polina Stepensky, Yuval Nevo, Hadar Benyamini, Sharona Elgavish, Osnat Almogi-Hazan & Batia Avni. (2023) Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Modulate Apoptosis, TNF Alpha and Interferon Gamma Response Gene mRNA Expression in T Lymphocytes. International Journal of Molecular Sciences 24:18, pages 13689.
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Zhiwei Liao, Bide Tong, Zixuan Ou, Junyu Wei, Ming Lei & Cao Yang. (2023) The role of extracellular vesicles in iron homeostasis and ferroptosis: Focus on musculoskeletal diseases. Traffic 24:9, pages 384-396.
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Anton Jan van Zonneveld, Qiao Zhao, Joris I. Rotmans & Roel Bijkerk. (2023) Circulating non-coding RNAs in chronic kidney disease and its complications. Nature Reviews Nephrology 19:9, pages 573-586.
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Simon Heidegger, Florian Stritzke, Sarah Dahl, Juliane Daßler-Plenker, Laura Joachim, Dominik Buschmann, Kaiji Fan, Carolin M. Sauer, Nils Ludwig, Christof Winter, Stefan Enssle, Suqi Li, Markus Perl, André Görgens, Tobias Haas, Erik Thiele Orberg, Sascha Göttert, Catherine Wölfel, Thomas Engleitner, Isidro Cortés-Ciriano, Roland Rad, Wolfgang Herr, Bernd Giebel, Jürgen Ruland, Florian Bassermann, Christoph Coch, Gunther Hartmann & Hendrik Poeck. (2023) Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy. Cell Reports Medicine 4:9, pages 101171.
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Bihan Xia, Yuzhi Liu, Jin Wang, Qing Lu, Xiuhe Lv, Kai Deng & Jinlin Yang. (2023) Emerging role of exosome-shuttled noncoding RNAs in gastrointestinal cancers: From intercellular crosstalk to clinical utility. Pharmacological Research 195, pages 106880.
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Abhimanyu Thakur. (2023) Organ-on-a-Chip Microfluidic Systems for Tracking Exosomal Dynamic Communication. OpenNano 13, pages 100179.
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Yingchang Ma, Steve Brocchini & Gareth R. Williams. (2023) Extracellular vesicle-embedded materials. Journal of Controlled Release 361, pages 280-296.
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Michael F. Gutknecht, Nichol E. Holodick & Thomas L. Rothstein. (2023) B cell extracellular vesicles contain monomeric IgM that binds antigen and enters target cells. iScience 26:9, pages 107526.
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Geovanny Genaro Reivan Ortiz, Neelam Hazoor Zaidi, Ravinder S Saini, Andres Alexis Ramirez Coronel, Tahani Alsandook, Methaq Hadi Lafta, José Luis Arias-Gonzáles, Ali H Amin & Renato R. Maaliw III. (2023) The developing role of extracellular vesicles in autoimmune diseases: special attention to mesenchymal stem cell-derived extracellular vesicles. International Immunopharmacology 122, pages 110531.
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Azadeh Amini, Faezeh Shekari, Sara Assar Kashani, Nasim Eslami, Abdoreza Nazari, Nahid Tofigh, Koorosh Shahpasand, Hamid Akbari Javar & Hossein Baharvand. (2023) Clonal mesenchymal stem cell-derived extracellular vesicles improve mouse model of weight drop-induced traumatic brain injury through reducing cistauosis and apoptosis. Experimental Neurology 367, pages 114467.
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Hanchae Cho, Inseong Jung, Hyunji Ju, Moon-Chang Baek & Kyungmoo Yea. (2023) Engineered CD8+ T cell-derived extracellular vesicles induce enhanced anti-cancer efficacy and targeting to lung cancer cells. Cytokine 169, pages 156249.
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Xiaodong Zhao, Yunkuo Li, Shouwang Wu, Yuxiong Wang, Bin Liu, Honglan Zhou & Faping Li. (2023) Role of extracellular vesicles in pathogenesis and therapy of renal ischemia-reperfusion injury. Biomedicine & Pharmacotherapy 165, pages 115229.
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Yafei Han, Liehu Cao, Guangfeng Li, Fengjin Zhou, Long Bai & Jiacan Su. (2023) Harnessing Nucleic Acids Nanotechnology for Bone/Cartilage Regeneration. Small 19:37.
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Nazma F. Ilahibaks, Marieke T. Roefs, Maike A. D. Brans, Christian Snijders Blok, Saskia C. A. de Jager, Raymond M. Schiffelers, Pieter Vader, Zhiyong Lei & Joost P. G. Sluijter. (2023) Extracellular vesicle‐mediated protein delivery to the liver. Journal of Extracellular Biology 2:9.
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Daniele Stajano, Franco L. Lombino, Michaela Schweizer, Markus Glatzel, Paul Saftig, Kira V. Gromova & Matthias Kneussel. (2023) Tetraspanin 15 depletion impairs extracellular vesicle docking at target neurons. Journal of Extracellular Biology 2:9.
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Will Thompson & Eleftherios Terry Papoutsakis. (2023) Similar but distinct: The impact of biomechanical forces and culture age on the production, cargo loading, and biological efficacy of human megakaryocytic extracellular vesicles for applications in cell and gene therapies. Bioengineering & Translational Medicine 8:5.
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Yixiao Gan, Gang Zhao, Zhicheng Wang, Xingcai Zhang, Mei X. Wu & Min Lu. (2023) Bacterial Membrane Vesicles: Physiological Roles, Infection Immunology, and Applications. Advanced Science 10:25.
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Min Xiao, Guiding Li & Hefeng Yang. (2023) Microbe-host interactions: structure and functions of Gram-negative bacterial membrane vesicles. Frontiers in Microbiology 14.
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Prashant Kumar, Darshan Mehta & John J. Bissler. (2023) Physiologically Based Pharmacokinetic Modeling of Extracellular Vesicles. Biology 12:9, pages 1178.
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Wang Yin, Cuong V. Pham, Shweta Patel, Rocky Chowdhury, Tuong N.‐G. Nguyen, Phuong H.L. Tran, Yimin Zhu & Wei Duan. 2023. Supramolecular Nanotechnology. Supramolecular Nanotechnology 667 688 .
Xinchi Qin, Jia He, Xiaoxiang Wang, Jingru Wang, Ronghua Yang & Xiaodong Chen. (2023) The functions and clinical application potential of exosomes derived from mesenchymal stem cells on wound repair: a review of recent research advances. Frontiers in Immunology 14.
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Wen-Xiu Cheng, Shao-Bin Wei, Yang Zhou, Yu Shao & Mao-Ya Li. (2023) Exosomes: potential diagnostic markers and drug carriers for adenomyosis. Frontiers in Pharmacology 14.
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Fangjun Huang, Yang He, Meng Zhang, Keren Luo, Jiawen Li, Jiali Li, Xinyu Zhang, Xiaoyan Dong & Jun Tang. (2023) Progress in Research on Stem Cells in Neonatal Refractory Diseases. Journal of Personalized Medicine 13:8, pages 1281.
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Di Lu, Jiu-Ping Wu, Qi-Wei Yang, Hua-Yi Wang, Jun-Jie Yang, Gang-Gang Zhang, Chen Wang, Yan-Lian Yang, Ling Zhu & Xin-Zhi Sun. (2023) Recent advances in lipid nanovesicles for targeted treatment of spinal cord injury. Frontiers in Bioengineering and Biotechnology 11.
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Yuchang Liu, Minrui Wang, Yang Yu, Chunhong Li & Chunxiang Zhang. (2023) Advances in the study of exosomes derived from mesenchymal stem cells and cardiac cells for the treatment of myocardial infarction. Cell Communication and Signaling 21:1.
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Lanyu Zhang, Jin Liu & Cheng Zhou. (2023) Current aspects of small extracellular vesicles in pain process and relief. Biomaterials Research 27:1.
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Guangchuan Zhang, Minghao Yao, Shanshan Ma, Kun Zhang, Yujue Wang, Zhimin Wang, Jiaheng Liang, Shan Dai, Ruimei Jin & Fangxia Guan. (2023) Application of cell membrane-functionalized biomimetic nanoparticles in the treatment of glioma. Journal of Materials Chemistry B 11:30, pages 7055-7068.
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Xue Liu, Jiao Li, Xuesong Yang, Xiaojie Li, Jing Kong, Dongyuan Qi, Fuyin Zhang, Bo Sun, Yuehua Liu & Tingjiao Liu. (2023) Carcinoma-associated fibroblast-derived lysyl oxidase-rich extracellular vesicles mediate collagen crosslinking and promote epithelial-mesenchymal transition via p-FAK/p-paxillin/YAP signaling. International Journal of Oral Science 15:1.
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Dennis K. Jeppesen, Qin Zhang, Jeffrey L. Franklin & Robert J. Coffey. (2023) Extracellular vesicles and nanoparticles: emerging complexities. Trends in Cell Biology 33:8, pages 667-681.
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Chan Zhang, Hao Hao, Yishi Wang, Nan Mu, Wenhua Jiang, Zihui Zhang, Yue Yin, Lu Yu, Alex Chia Yu Chang & Heng Ma. (2023) Intercellular mitochondrial component transfer triggers ischemic cardiac fibrosis. Science Bulletin 68:16, pages 1784-1799.
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Yeonwoo Jang, April Kim, James J. Moon, Jae Young Lee & Hansoo Park. (2023) Novel bioengineering strategies for drug delivery systems. Applied Materials Today 33, pages 101834.
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Christopher D Gregory & Michael P Rimmer. (2023) Extracellular vesicles arising from apoptosis: forms, functions, and applications. The Journal of Pathology 260:5, pages 592-608.
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Thach Tuan Pham, Anh Hong Le, Cong Phi Dang, Suet Yen Chong, Dang Vinh Do, Boya Peng, Migara Kavishka Jayasinghe, Hong Boon Ong, Dong Van Hoang, Roma Anne Louise, Yuin‐Han Loh, Han Wei Hou, Jiong‐Wei Wang & Minh TN Le. (2023) Endocytosis of red blood cell extracellular vesicles by macrophages leads to cytoplasmic heme release and prevents foam cell formation in atherosclerosis. Journal of Extracellular Vesicles 12:8.
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Kaushik Das, Subhojit Paul, Tanmoy Mukherjee, Arnab Ghosh, Anshul Sharma, Prem Shankar, Saurabh Gupta, Shiva Keshava & Deepak Parashar. (2023) Beyond Macromolecules: Extracellular Vesicles as Regulators of Inflammatory Diseases. Cells 12:15, pages 1963.
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Jakub Kulus, Wiesława Kranc, Magdalena Kulus, Dorota Bukowska, Hanna Piotrowska-Kempisty, Paul Mozdziak, Bartosz Kempisty & Paweł Antosik. (2023) New Gene Markers of Exosomal Regulation Are Involved in Porcine Granulosa Cell Adhesion, Migration, and Proliferation. International Journal of Molecular Sciences 24:14, pages 11873.
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Baoye He, Huan Wang, Guosheng Liu, Angela Chen, Alejandra Calvo, Qiang Cai & Hailing Jin. (2023) Fungal small RNAs ride in extracellular vesicles to enter plant cells through clathrin-mediated endocytosis. Nature Communications 14:1.
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