Journal of Extracellular Vesicles, Volume 3, Issue 1 (2014)

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Journal of Extracellular Vesicles, Volume 3, Issue 1 (2014)

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Editorials

Editorial
Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles
Jan Lötvall, Andrew F. Hill, Fred Hochberg, Edit I. Buzás, Dolores Di Vizio, Christopher Gardiner, Yong Song Gho, Igor V. Kurochkin, Suresh Mathivanan, Peter Quesenberry, Susmita Sahoo, Hidetoshi Tahara, Marca H. Wauben, Kenneth W. Witwer & Clotilde Théry
Article: 26913
Published online: 22 Dec 2014
AbstractforMinimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles | Full Text | References | PDF (377.6 KB)
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Review Articles

Review Article
Extracellular vesicles in parasitic diseases
Antonio Marcilla, Lorena Martin-Jaular, Maria Trelis, Armando de Menezes-Neto, Antonio Osuna, Dolores Bernal, Carmen Fernandez-Becerra, Igor C. Almeida & Hernando A. del Portillo
Article: 25040
Published online: 22 Dec 2014
AbstractforExtracellular vesicles in parasitic diseases | Full Text | References | PDF (1.2 MB)
  • 4554 Views
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Review Article
Routes and mechanisms of extracellular vesicle uptake
Laura Ann Mulcahy, Ryan Charles Pink & David Raul Francisco Carter
Article: 24641
Published online: 04 Aug 2014
AbstractforRoutes and mechanisms of extracellular vesicle uptake | Full Text | References | PDF (1.1 MB)
  • 29394 Views
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Review Article
Contributing role of extracellular vesicles on vascular endothelium haemostatic balance in cancer
Céline Bouvy, Damien Gheldof, Christian Chatelain, François Mullier & Jean-Michel Dogné
Article: 24400
Published online: 11 Jul 2014
AbstractforContributing role of extracellular vesicles on vascular endothelium haemostatic balance in cancer | Full Text | References | PDF (652.9 KB)
  • 1040 Views
  • 10 CrossRef citations
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Review Article
The central role of extracellular vesicles in the mechanisms of thrombosis in paroxysmal nocturnal haemoglobinuria: a review
Bérangère Devalet, François Mullier, Bernard Chatelain, Jean-Michel Dogné & Christian Chatelain
Article: 23304
Published online: 24 Mar 2014
AbstractforThe central role of extracellular vesicles in the mechanisms of thrombosis in paroxysmal nocturnal haemoglobinuria: a review | Full Text | References | PDF (759.2 KB)
  • 772 Views
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Original Research Articles

Article
Effect of storage on physical and functional properties of extracellular vesicles derived from neutrophilic granulocytes
Ákos M. Lőrincz, Csaba I. Timár, Krisztina A. Marosvári, Dániel S. Veres, Lilla Otrokocsi, Ágnes Kittel & Erzsébet Ligeti
Article: 25465
Published online: 22 Dec 2014
AbstractforEffect of storage on physical and functional properties of extracellular vesicles derived from neutrophilic granulocytes | Full Text | References | PDF (1.8 MB)
  • 3310 Views
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Article
Analysis of AKT and ERK1/2 protein kinases in extracellular vesicles isolated from blood of patients with cancer
Johannes C. van der Mijn, Nik Sol, Wouter Mellema, Connie R. Jimenez, Sander R. Piersma, Henk Dekker, Lisette M. Schutte, Egbert F. Smit, Henk J. Broxterman, Johan Skog, Bakhos A. Tannous, Thomas Wurdinger & Henk M. W. Verheul
Article: 25657
Published online: 08 Dec 2014
AbstractforAnalysis of AKT and ERK1/2 protein kinases in extracellular vesicles isolated from blood of patients with cancer | Full Text | References | PDF (1.2 MB) | Supplemental
  • 1342 Views
  • 25 CrossRef citations
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Article
Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol
Joshua D. Hutcheson, Claudia Goettsch, Tan Pham, Masaya Iwashita, Masanori Aikawa, Sasha A. Singh & Elena Aikawa
Article: 25129
Published online: 05 Dec 2014
AbstractforEnrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol | Full Text | References | PDF (1.3 MB)
  • 1046 Views
  • 36 CrossRef citations
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Article
Measurement of refractive index by nanoparticle tracking analysis reveals heterogeneity in extracellular vesicles
Chris Gardiner, Michael Shaw, Patrick Hole, Jonathan Smith, Dionne Tannetta, Christopher W. Redman & Ian L. Sargent
Article: 25361
Published online: 24 Nov 2014
AbstractforMeasurement of refractive index by nanoparticle tracking analysis reveals heterogeneity in extracellular vesicles | Full Text | References | PDF (698.2 KB) | Supplemental
  • 3963 Views
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Article
Exosomes secreted by cortical neurons upon glutamatergic synapse activation specifically interact with neurons
Mathilde Chivet, Charlotte Javalet, Karine Laulagnier, Béatrice Blot, Fiona J. Hemming & Rémy Sadoul
Article: 24722
Published online: 13 Nov 2014
AbstractforExosomes secreted by cortical neurons upon glutamatergic synapse activation specifically interact with neurons | Full Text | References | PDF (9 MB)
  • 4677 Views
  • 200 CrossRef citations
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Article
Comparative analysis of discrete exosome fractions obtained by differential centrifugation
Dennis K. Jeppesen, Michael L. Hvam, Bjarke Primdahl-Bengtson, Anders T. Boysen, Bradley Whitehead, Lars Dyrskjøt, Torben F. Ørntoft, Kenneth A. Howard & Marie S. Ostenfeld
Article: 25011
Published online: 06 Nov 2014
AbstractforComparative analysis of discrete exosome fractions obtained by differential centrifugation | Full Text | References | PDF (2.3 MB) | Supplemental
  • 7100 Views
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Article
Levels of procoagulant microvesicles are elevated after traumatic injury and platelet microvesicles are negatively correlated with mortality
Nicola Curry, Amber Raja, James Beavis, Simon Stanworth & Paul Harrison
Article: 25625
Published online: 31 Oct 2014
AbstractforLevels of procoagulant microvesicles are elevated after traumatic injury and platelet microvesicles are negatively correlated with mortality | Full Text | References | PDF (584.6 KB)
  • 716 Views
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Article
Procoagulant and platelet-derived microvesicle absolute counts determined by flow cytometry correlates with a measurement of their functional capacity
Lisa Ayers, Paul Harrison, Malcolm Kohler & Berne Ferry
Article: 25348
Published online: 30 Sep 2014
AbstractforProcoagulant and platelet-derived microvesicle absolute counts determined by flow cytometry correlates with a measurement of their functional capacity | Full Text | References | PDF (1.6 MB)
  • 885 Views
  • 24 CrossRef citations
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Article
Importance of exosome depletion protocols to eliminate functional and RNA-containing extracellular vesicles from fetal bovine serum
Ganesh Vilas Shelke, Cecilia Lässer, Yong Song Gho & Jan Lötvall
Article: 24783
Published online: 30 Sep 2014
AbstractforImportance of exosome depletion protocols to eliminate functional and RNA-containing extracellular vesicles from fetal bovine serum | Full Text | References | PDF (1.1 MB) | Supplemental
  • 9922 Views
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Article
Informatic system for a global tissue–fluid biorepository with a graph theory–oriented graphical user interface
William E. Butler, Nadia Atai, Bob Carter & Fred Hochberg
Article: 24247
Published online: 22 Sep 2014
AbstractforInformatic system for a global tissue–fluid biorepository with a graph theory–oriented graphical user interface | Full Text | References | PDF (1.3 MB)
  • 759 Views
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Article
The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling
Jan Van Deun, Pieter Mestdagh, Raija Sormunen, Veronique Cocquyt, Karim Vermaelen, Jo Vandesompele, Marc Bracke, Olivier De Wever & An Hendrix
Article: 24858
Published online: 18 Sep 2014
AbstractforThe impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling | Full Text | References | PDF (2.3 MB) | Supplemental
  • 13425 Views
  • 608 CrossRef citations
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Article
Single-step isolation of extracellular vesicles by size-exclusion chromatography
Anita N. Böing, Edwin van der Pol, Anita E. Grootemaat, Frank A. W. Coumans, Auguste Sturk & Rienk Nieuwland
Article: 23430
Published online: 08 Sep 2014
AbstractforSingle-step isolation of extracellular vesicles by size-exclusion chromatography | Full Text | References | PDF (1.7 MB) | Supplemental
  • 23997 Views
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Article
Different immunogenicity but similar antitumor efficacy of two DNA vaccines coding for an antigen secreted in different membrane vesicle-associated forms
Christine Sedlik, James Vigneron, Lea Torrieri-Dramard, Fabien Pitoiset, Jordan Denizeau, Caroline Chesneau, Philippe de la Rochere, Olivier Lantz, Clotilde Thery & Bertrand Bellier
Article: 24646
Published online: 27 Aug 2014
AbstractforDifferent immunogenicity but similar antitumor efficacy of two DNA vaccines coding for an antigen secreted in different membrane vesicle-associated forms | Full Text | References | PDF (632.3 KB) | Supplemental
  • 1488 Views
  • 31 CrossRef citations
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Article
Proteome analysis of multidrug-resistant, breast cancer–derived microparticles
Deep Pokharel, Matthew P. Padula, Jamie F. Lu, Jessica L. Tacchi, Frederick Luk, Steven P. Djordjevic & Mary Bebawy
Article: 24384
Published online: 22 Aug 2014
AbstractforProteome analysis of multidrug-resistant, breast cancer–derived microparticles | Full Text | References | PDF (1,009 KB) | Supplemental
  • 1233 Views
  • 42 CrossRef citations
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Article
Recovery of extracellular vesicles from human breast milk is influenced by sample collection and vesicle isolation procedures
Marijke I. Zonneveld, Alain R. Brisson, Martijn J. C. van Herwijnen, Sisareuth Tan, Chris H. A. van de Lest, Frank A. Redegeld, Johan Garssen, Marca H. M. Wauben & Esther N. M. Nolte-'t Hoen
Article: 24215
Published online: 14 Aug 2014
AbstractforRecovery of extracellular vesicles from human breast milk is influenced by sample collection and vesicle isolation procedures | Full Text | References | PDF (4.7 MB) | Supplemental
  • 5180 Views
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Article
Characterization of physical properties of tissue factor–containing microvesicles and a comparison of ultracentrifuge-based recovery procedures
Camille Ettelaie, Mary E. W. Collier, Anthony Maraveyas & Rammile Ettelaie
Article: 23592
Published online: 13 Aug 2014
AbstractforCharacterization of physical properties of tissue factor–containing microvesicles and a comparison of ultracentrifuge-based recovery procedures | Full Text | References | PDF (937 KB) | Supplemental
  • 1105 Views
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Article
Antibody-mediated immunity induced by engineered Escherichia coli OMVs carrying heterologous antigens in their lumen
Laura Fantappiè, Micaela de Santis, Emiliano Chiarot, Filippo Carboni, Giuliano Bensi, Olivier Jousson, Immaculada Margarit & Guido Grandi
Article: 24015
Published online: 11 Aug 2014
AbstractforAntibody-mediated immunity induced by engineered Escherichia coli OMVs carrying heterologous antigens in their lumen | Full Text | References | PDF (1.3 MB)
  • 2741 Views
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Article
Isolation and characterization of platelet-derived extracellular vesicles
Maria T. Aatonen, Tiina Öhman, Tuula A. Nyman, Saara Laitinen, Mikaela Grönholm & Pia R.-M. Siljander
Article: 24692
Published online: 06 Aug 2014
AbstractforIsolation and characterization of platelet-derived extracellular vesicles | Full Text | References | PDF (3.3 MB) | Supplemental
  • 8312 Views
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Article
Cavin-1/PTRF alters prostate cancer cell-derived extracellular vesicle content and internalization to attenuate extracellular vesicle-mediated osteoclastogenesis and osteoblast proliferation
Kerry L. Inder, Jayde E. Ruelcke, Lara Petelin, Hyeongsun Moon, Eunju Choi, James Rae, Antje Blumenthal, Dietmar Hutmacher, Nicholas A. Saunders, Jennifer L. Stow, Robert G. Parton & Michelle M. Hill
Article: 23784
Published online: 25 Jun 2014
AbstractforCavin-1/PTRF alters prostate cancer cell-derived extracellular vesicle content and internalization to attenuate extracellular vesicle-mediated osteoclastogenesis and osteoblast proliferation | Full Text | References | PDF (2.1 MB) | Supplemental
  • 2070 Views
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Article
Membrane phospholipid redistribution in cancer micro-particles and implications in the recruitment of cationic protein factors
Songwang Hou, Doris Grillo, Carol L. Williams, J. Andrew Wasserstrom, Igal Szleifer & Ming Zhao
Article: 22653
Published online: 11 Jun 2014
AbstractforMembrane phospholipid redistribution in cancer micro-particles and implications in the recruitment of cationic protein factors | Full Text | References | PDF (1 MB) | Supplemental
  • 517 Views
  • 9 CrossRef citations
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Article
Anti-proliferative and anti-tumour effects of lymphocyte-derived microparticles are neither species- nor tumour-type specific
Chun Yang, Wei Xiong, Qian Qiu, Houda Tahiri, Rosanne Superstein, Anne-Sophie Carret, Przemyslaw Sapieha & Pierre Hardy
Article: 23034
Published online: 09 May 2014
AbstractforAnti-proliferative and anti-tumour effects of lymphocyte-derived microparticles are neither species- nor tumour-type specific | Full Text | References | PDF (683.3 KB)
  • 680 Views
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Article
Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood
Lesley Cheng, Robyn A. Sharples, Benjamin J. Scicluna & Andrew F. Hill
Article: 23743
Published online: 26 Mar 2014
AbstractforExosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood | Full Text | References | PDF (5.5 MB) | Supplemental
  • 7572 Views
  • 536 CrossRef citations
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Article
The HIV Nef protein modulates cellular and exosomal miRNA profiles in human monocytic cells
Madeeha Aqil, Afsar Raza Naqvi, Saurav Mallik, Sanghamitra Bandyopadhyay, Ujjwal Maulik & Shahid Jameel
Article: 23129
Published online: 25 Mar 2014
AbstractforThe HIV Nef protein modulates cellular and exosomal miRNA profiles in human monocytic cells | Full Text | References | PDF (1.6 MB) | Supplemental
  • 1457 Views
  • 70 CrossRef citations
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Article
The influence of rotor type and centrifugation time on the yield and purity of extracellular vesicles
Aleksander Cvjetkovic, Jan Lötvall & Cecilia Lässer
Article: 23111
Published online: 25 Mar 2014
AbstractforThe influence of rotor type and centrifugation time on the yield and purity of extracellular vesicles | Full Text | References | PDF (1.8 MB)
  • 9648 Views
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Article
The endocytosis gene END3 is essential for the glucose-induced rapid decline of small vesicles in the extracellular fraction in Saccharomyces cerevisiae
Bennett J. Giardina, Kathryn Stein & Hui-Ling Chiang
Article: 23497
Published online: 21 Mar 2014
AbstractforThe endocytosis gene END3 is essential for the glucose-induced rapid decline of small vesicles in the extracellular fraction in Saccharomyces cerevisiae | Full Text | References | PDF (1.3 MB) | Supplemental
  • 897 Views
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Article
Extracellular vesicles from a muscle cell line (C2C12) enhance cell survival and neurite outgrowth of a motor neuron cell line (NSC-34)
Roger D. Madison, Christopher McGee, Renee Rawson & Grant A. Robinson
Article: 22865
Published online: 19 Feb 2014
AbstractforExtracellular vesicles from a muscle cell line (C2C12) enhance cell survival and neurite outgrowth of a motor neuron cell line (NSC-34) | Full Text | References | PDF (1.3 MB) | Supplemental
  • 2063 Views
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Article
Enhancement of Gemcitabine sensitivity in pancreatic adenocarcinoma by novel exosome-mediated delivery of the Survivin-T34A mutant
Jonathan R. Aspe, Carlos J. Diaz Osterman, Jessica M.S. Jutzy, Simone Deshields, Sonia Whang & Nathan R. Wall
Article: 23244
Published online: 17 Feb 2014
AbstractforEnhancement of Gemcitabine sensitivity in pancreatic adenocarcinoma by novel exosome-mediated delivery of the Survivin-T34A mutant | Full Text | References | PDF (2.6 MB)
  • 1478 Views
  • 80 CrossRef citations
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Article
Towards traceable size determination of extracellular vesicles
Zoltán Varga, Yuana Yuana, Anita E. Grootemaat, Edwin van der Pol, Christian Gollwitzer, Michael Krumrey & Rienk Nieuwland
Article: 23298
Published online: 04 Feb 2014
AbstractforTowards traceable size determination of extracellular vesicles | Full Text | References | PDF (1.5 MB) | Supplemental
  • 2522 Views
  • 89 CrossRef citations
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Article
A flow cytometric method for characterization of circulating cell-derived microparticles in plasma
Morten Hjuler Nielsen, Henning Beck-Nielsen, Morten Nørgaard Andersen & Aase Handberg
Article: 20795
Published online: 04 Feb 2014
AbstractforA flow cytometric method for characterization of circulating cell-derived microparticles in plasma | Full Text | References | PDF (1.6 MB)
  • 2458 Views
  • 88 CrossRef citations
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Short Communications

Brief Report
Co-isolation of extracellular vesicles and high-density lipoproteins using density gradient ultracentrifugation
Yuana Yuana, Johannes Levels, Anita Grootemaat, Auguste Sturk & Rienk Nieuwland
Article: 23262
Published online: 08 Jul 2014
AbstractforCo-isolation of extracellular vesicles and high-density lipoproteins using density gradient ultracentrifugation | Full Text | References | PDF (795.2 KB)
  • 4501 Views
  • 233 CrossRef citations
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Article
Clinical CVVH model removes endothelium-derived microparticles from circulation
Abdelhafeez H. Abdelhafeez, Paul M. Jeziorczak, Terry R. Schaid, Susan L. Hoefs, Sushma Kaul, Rahul Nanchal, Elizabeth R. Jacobs & John C. Densmore
Article: 23498
Published online: 27 Feb 2014
AbstractforClinical CVVH model removes endothelium-derived microparticles from circulation | Full Text | References | PDF (1 MB)
  • 629 Views
  • 8 CrossRef citations
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Technical Reports

Article
Reproducible extracellular vesicle size and concentration determination with tunable resistive pulse sensing
Frank A. W. Coumans, Edwin van der Pol, Anita N. Böing, Najat Hajji, Guus Sturk, Ton G. van Leeuwen & Rienk Nieuwland
Article: 25922
Published online: 10 Dec 2014
AbstractforReproducible extracellular vesicle size and concentration determination with tunable resistive pulse sensing | Full Text | References | PDF (951.7 KB)
  • 2270 Views
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Obituary

Obituary
F. Hochberg
Article: 23842
Published online: 03 Feb 2014
CitationforObituary | Full Text | PDF (343.3 KB)
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Supplement 1, 2014

Abstract
Third International Meeting of ISEV 2014: Rotterdam, The Netherlands, April 30th – May 3rd, 2014
Article: 24214
Published online: 25 Apr 2014
First Page PreviewforThird International Meeting of ISEV 2014: Rotterdam, The Netherlands, April 30th – May 3rd, 2014 | PDF (1.9 MB)
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