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Vinita Chauhan, Jihang Yu, Ngoc Vuong, Lynne T. Haber, Andrew Williams, Scott S. Auerbach, Danielle Beaton, Yi Wang, Robert Stainforth, Ruth C. Wilkins, Edouard I. Azzam, Richard B. Richardson, Md Gulam Musawwir Khan, Ashok Jadhav, Julie J. Burtt, Julie Leblanc, Kristi Randhawa, Knut Erik Tollefsen & Carole L. Yauk. (2023) Considerations for application of benchmark dose modeling in radiation research: workshop highlights. International Journal of Radiation Biology 99:9, pages 1320-1331.
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Samuel M. Cohen, Christopher Bevan, Bhaskar Gollapudi & James E. Klaunig. (2023) Evaluation of the carcinogenicity of carbon tetrachloride. Journal of Toxicology and Environmental Health, Part B 26:6, pages 342-370.
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Tomoya Yamada, Samuel M. Cohen & Brian G Lake. (2022) Response to Letter to the Editor from Drs. van Kesteren, Pronk, Heusinkveld, Luijten and Hakkert concerning Yamada et al. (2021): Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR). Crit. Rev. Toxicol. Vol. 51: 373-394.. Critical Reviews in Toxicology 52:5, pages 399-402.
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Tomoya Yamada, Brian G. Lake & Samuel M. Cohen. (2022) Evaluation of the human hazard of the liver and lung tumors in mice treated with permethrin based on mode of action. Critical Reviews in Toxicology 52:1, pages 1-31.
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Susan P. Felter, Virunya S. Bhat, Philip A. Botham, David A. Bussard, Warren Casey, A. Wallace Hayes, Gina M. Hilton, Kelly A. Magurany, Ursula G. Sauer & Edward V. Ohanian. (2021) Assessing chemical carcinogenicity: hazard identification, classification, and risk assessment. Insight from a Toxicology Forum state-of-the-science workshop. Critical Reviews in Toxicology 51:8, pages 653-694.
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Tomoya Yamada, Samuel M. Cohen & Brian G. Lake. (2021) Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR). Critical Reviews in Toxicology 51:5, pages 373-394.
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Chad M. Thompson, Robinan Gentry, Seneca Fitch, Kun Lu & Harvey J. Clewell. (2020) An updated mode of action and human relevance framework evaluation for Formaldehyde-Related nasal tumors. Critical Reviews in Toxicology 50:10, pages 919-952.
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Robinan Gentry, Chad M. Thompson, Allison Franzen, Joshua Salley, Richard Albertini, Kun Lu & Tracy Greene. (2020) Using mechanistic information to support evidence integration and synthesis: a case study with inhaled formaldehyde and leukemia. Critical Reviews in Toxicology 50:10, pages 885-918.
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Harm Heusinkveld, Hedwig Braakhuis, Robin Gommans, Phil Botham, Marco Corvaro, Jan Willem van der Laan, Dick Lewis, Federica Madia, Irene Manou, Frédéric Schorsch, Gerrit Wolterink, Ruud Woutersen, Raffaella Corvi, Jyotigna Mehta & Mirjam Luijten. (2020) Towards a mechanism-based approach for the prediction of nongenotoxic carcinogenic potential of agrochemicals. Critical Reviews in Toxicology 50:9, pages 725-739.
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Samuel M. Cohen, Yan Zhongyu & James S. Bus. (2020) Relevance of mouse lung tumors to human risk assessment. Journal of Toxicology and Environmental Health, Part B 23:5, pages 214-241.
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Susan P. Felter, Alan R. Boobis, Philip A. Botham, Alice Brousse, Helmut Greim, Heli M. Hollnagel & Ursula G. Sauer. (2020) Hazard identification, classification, and risk assessment of carcinogens: too much or too little? – Report of an ECETOC workshop. Critical Reviews in Toxicology 50:1, pages 72-95.
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Adeline Clergé, Jérémie Le Goff, Claire Lopez, Jérôme Ledauphin & Raphaël Delépée. (2019) Oxy-PAHs: occurrence in the environment and potential genotoxic/mutagenic risk assessment for human health. Critical Reviews in Toxicology 49:4, pages 302-328.
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Joyce S. Tsuji, Ellen T. Chang, P. Robinan Gentry, Harvey J. Clewell, Paolo Boffetta & Samuel M. Cohen. (2019) Dose-response for assessing the cancer risk of inorganic arsenic in drinking water: the scientific basis for use of a threshold approach. Critical Reviews in Toxicology 49:1, pages 36-84.
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Harvey J. Clewell, Janice W. Yager, Tracy B. Greene & P. Robinan Gentry. (2018) Application of the adverse outcome pathway (AOP) approach to inform mode of action (MOA): A case study with inorganic arsenic. Journal of Toxicology and Environmental Health, Part A 81:18, pages 893-912.
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David Adenuga, Katy Goyak & R. Jeffrey Lewis. (2017) Evaluating the MoA/human relevance framework for F-344 rat liver epithelioid granulomas with mineral oil hydrocarbons. Critical Reviews in Toxicology 47:9, pages 754-770.
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Alan Boobis, Paul Brown, Mark Timothy David Cronin, James Edwards, Corrado Lodovico Galli, Jay Goodman, Abigail Jacobs, David Kirkland, Mirjam Luijten, Cyril Marsaux, Matthew Martin, Chihae Yang & Heli Miriam Hollnagel. (2017) Origin of the TTC values for compounds that are genotoxic and/or carcinogenic and an approach for their re-evaluation. Critical Reviews in Toxicology 47:8, pages 710-732.
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Mirjam Luijten, Evelyn D. Olthof, Betty C. Hakkert, Emiel Rorije, Jan-Willem van der Laan, Ruud A. Woutersen & Jan van Benthem. (2016) An integrative test strategy for cancer hazard identification. Critical Reviews in Toxicology 46:7, pages 615-639.
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Atta Rasool, Abida Farooqi, Sajid Masood & Khadim Hussain. (2016) Arsenic in groundwater and its health risk assessment in drinking water of Mailsi, Punjab, Pakistan. Human and Ecological Risk Assessment: An International Journal 22:1, pages 187-202.
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Lisa M. Sweeney, Janet E. Kester, Christopher R. Kirman, P. Robinan Gentry, Marcy I. Banton, James S. Bus & Michael L. Gargas. (2015) Risk assessments for chronic exposure of children and prospective parents to ethylbenzene (CAS No. 100-41-4). Critical Reviews in Toxicology 45:8, pages 662-726.
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David Rouquié, Marjoke Heneweer, Jane Botham, Hans Ketelslegers, Lauren Markell, Thomas Pfister, Winfried Steiling, Volker Strauss & Christa Hennes. (2015) Contribution of new technologies to characterization and prediction of adverse effects. Critical Reviews in Toxicology 45:2, pages 172-183.
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James S. Bus, Marcy I. Banton, Willem D. Faber, Christopher R. Kirman, Douglas B. McGregor & Daniel B. Pourreau. (2015) Human health screening level risk assessments of tertiary-butyl acetate (TBAC): Calculated acute and chronic reference concentration (RfC) and Hazard Quotient (HQ) values based on toxicity and exposure scenario evaluations. Critical Reviews in Toxicology 45:2, pages 142-171.
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Nikolai L. Chepelev, Ivy D. Moffat, Sarah Labib, Julie Bourdon-Lacombe, Byron Kuo, Julie K. Buick, France Lemieux, Amal I. Malik, Sabina Halappanavar, Andrew Williams & Carole L. Yauk. (2015) Integrating toxicogenomics into human health risk assessment: Lessons learned from the benzo[a]pyrene case study. Critical Reviews in Toxicology 45:1, pages 44-52.
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Ivy Moffat, Nikolai L. Chepelev, Sarah Labib, Julie Bourdon-Lacombe, Byron Kuo, Julie K. Buick, France Lemieux, Andrew Williams, Sabina Halappanavar, Amal I Malik, Mirjam Luijten, Jiri Aubrecht, Daniel R. Hyduke, Albert J. Fornace$suffix/text()$suffix/text(), Carol D. Swartz, Leslie Recio & Carole L. Yauk. (2015) Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water. Critical Reviews in Toxicology 45:1, pages 1-43.
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Ted W. Simon, S. Stoney Simons$suffix/text()$suffix/text(), R. Julian Preston, Alan R. Boobis, Samuel M. Cohen, Nancy G. Doerrer, Penelope A. Fenner-Crisp, Tami S. McMullin, Charlene A. McQueen & J. Craig Rowlands. (2014) The use of mode of action information in risk assessment: Quantitative key events/dose-response framework for modeling the dose-response for key events. Critical Reviews in Toxicology 44:sup3, pages 17-43.
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Claire Terry, Reza J. Rasoulpour, Shakil Saghir, Sue Marty, B. Bhaskar Gollapudi & Richard Billington. (2014) Application of a novel integrated toxicity testing strategy incorporating “3R” principles of animal research to evaluate the safety of a new agrochemical sulfoxaflor. Critical Reviews in Toxicology 44:sup2, pages 1-14.
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Robert G. Ellis-Hutchings, Reza J. Rasoulpour, Claire Terry, Edward W. Carney & Richard Billington. (2014) Human relevance framework evaluation of a novel rat developmental toxicity mode of action induced by sulfoxaflor. Critical Reviews in Toxicology 44:sup2, pages 45-62.
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Matthew J. LeBaron, B. Bhaskar Gollapudi, Claire Terry, Richard Billington & Reza J. Rasoulpour. (2014) Human relevance framework for rodent liver tumors induced by the insecticide sulfoxaflor. Critical Reviews in Toxicology 44:sup2, pages 15-24.
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Reza J. Rasoulpour, Claire Terry, Matthew J. LeBaron, Kenneth Stebbins, Robert G. Ellis-Hutchings & Richard Billington. (2014) Mode-of-action and human relevance framework analysis for rat Leydig cell tumors associated with sulfoxaflor. Critical Reviews in Toxicology 44:sup2, pages 25-44.
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Mitscheli Sanches Da Rocha, Lora L. Arnold, Maria Luiza Cotrim Sartor De Oliveira, Shadia M. Ihlaseh Catalano, Ana Paula Ferragut Cardoso, Merielen G. N. Pontes, Bianca Ferrucio, Puttappa R. Dodmane, Samuel M. Cohen & João Lauro V. De Camargo. (2014) Diuron-induced rat urinary bladder carcinogenesis: Mode of action and human relevance evaluations using the International Programme on Chemical Safety framework. Critical Reviews in Toxicology 44:5, pages 393-406.
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Lynn H. Pottenger, Larry S. Andrews, Ammie N. Bachman, Peter J. Boogaard, Jean Cadet, Michelle R. Embry, Peter B. Farmer, Matthew W. Himmelstein, Annie M. Jarabek, Elizabeth A. Martin, Robert J. Mauthe, Rudranath Persaud, R. Julian Preston, Rita Schoeny, Julie Skare, James A. Swenberg, Gary M. Williams, Errol Zeiger, Fagen Zhang & James H. Kim. (2014) An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride. Critical Reviews in Toxicology 44:4, pages 348-391.
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R. A. Budinsky, D. Schrenk, T. Simon, M. Van den Berg, J. F. Reichard, J. B. Silkworth, L. L. Aylward, A. Brix, T. Gasiewicz, N. Kaminski, G. Perdew, T. B. Starr, N. J. Walker & J. C. Rowlands. (2014) Mode of action and dose–response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study. Critical Reviews in Toxicology 44:1, pages 83-119.
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Clifford R. Elcombe, Richard C. Peffer, Douglas C. Wolf, Jason Bailey, Remi Bars, David Bell, Russell C. Cattley, Stephen S. Ferguson, David Geter, Amber Goetz, Jay I. Goodman, Susan Hester, Abigail Jacobs, Curtis J. Omiecinski, Rita Schoeny, Wen Xie & Brian G. Lake. (2014) Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator. Critical Reviews in Toxicology 44:1, pages 64-82.
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Melvin E. Andersen, R. Julian Preston, Andrew Maier, Alison M. Willis & Jacqueline Patterson. (2014) Dose–response approaches for nuclear receptor-mediated modes of action for liver carcinogenicity: Results of a workshop. Critical Reviews in Toxicology 44:1, pages 50-63.
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J. Christopher Corton, Michael L. Cunningham, B. Timothy Hummer, Christopher Lau, Bette Meek, Jeffrey M. Peters, James A. Popp, Lorenz Rhomberg, Jennifer Seed & James E. Klaunig. (2014) Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study. Critical Reviews in Toxicology 44:1, pages 1-49.
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Drew R. Ekman, Gerald T. Ankley, Vicki S. Blazer, Timothy W. Collette, Natàlia Garcia-Reyero, Luke R. Iwanowicz, Zachary G. Jorgenson, Kathy E. Lee, Pat M. Mazik, David H. Miller, Edward J. Perkins, Edwin T. Smith, Joseph E. Tietge & Daniel L. Villeneuve. (2013) Environmental Reviews and Case Studies: Biological Effects–Based Tools for Monitoring Impacted Surface Waters in the Great Lakes: A Multiagency Program in Support of the Great Lakes Restoration Initiative. Environmental Practice 15:4, pages 409-426.
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Lorenz R. Rhomberg, Julie E. Goodman, Lisa A. Bailey, Robyn L. Prueitt, Nancy B. Beck, Christopher Bevan, Michael Honeycutt, Norbert E. Kaminski, Greg Paoli, Lynn H. Pottenger, Roberta W. Scherer, Kimberly C. Wise & Richard A. Becker. (2013) A survey of frameworks for best practices in weight-of-evidence analyses. Critical Reviews in Toxicology 43:9, pages 753-784.
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Samuel M. Cohen, Lora L. Arnold, Barbara D. Beck, Ari S. Lewis & Michal Eldan. (2013) Evaluation of the carcinogenicity of inorganic arsenic. Critical Reviews in Toxicology 43:9, pages 711-752.
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Chad M. Thompson, Deborah M. Proctor, Mina Suh, Laurie C. Haws, Christopher R. Kirman & Mark A. Harris. (2013) Assessment of the mode of action underlying development of rodent small intestinal tumors following oral exposure to hexavalent chromium and relevance to humans. Critical Reviews in Toxicology 43:3, pages 244-274.
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DouglasL. Weed. (2013) The Quality of Nutrition and Cancer Reviews: A Systematic Assessment. Critical Reviews in Food Science and Nutrition 53:3, pages 276-286.
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Robyn L. Prueitt, Julie E. Goodman, Lisa A. Bailey & Lorenz R. Rhomberg. (2011) Hypothesis-based weight-of-evidence evaluation of the neurodevelopmental effects of chlorpyrifos. Critical Reviews in Toxicology 41:10, pages 822-903.
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Robert Golden. (2011) Identifying an indoor air exposure limit for formaldehyde considering both irritation and cancer hazards. Critical Reviews in Toxicology 41:8, pages 672-721.
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P. Robinan Gentry, Harvey J. Clewell$suffix/text()$suffix/text(), Rebecca Clewell, Jerry Campbell, Cynthia Van Landingham & Annette M. Shipp. (2011) Challenges in the application of quantitative approaches in risk assessment: a case study with di-(2-ethylhexyl)phthalate. Critical Reviews in Toxicology 41:sup2, pages 1-72.
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Julie E. Goodman, Robyn L. Prueitt, Sagar Thakali & Adriana R. Oller. (2011) The nickel ion bioavailability model of the carcinogenic potential of nickel-containing substances in the lung. Critical Reviews in Toxicology 41:2, pages 142-174.
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Christopher R. Kirman, Richard A. Albertini & Michael L. Gargas. (2010) 1,3-Butadiene: III. Assessing carcinogenic modes of action. Critical Reviews in Toxicology 40:sup1, pages 74-92.
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Lorenz R. Rhomberg, Lisa A. Bailey & Julie E. Goodman. (2010) Hypothesis-based weight of evidence: A tool for evaluating and communicating uncertainties and inconsistencies in the large body of evidence in proposing a carcinogenic mode of action—naphthalene as an example. Critical Reviews in Toxicology 40:8, pages 671-696.
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Douglas McGregor. (2010) Tertiary-Butanol: A toxicological review. Critical Reviews in Toxicology 40:8, pages 697-727.
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Samuel M. Cohen, Elliot B. Gordon, Pramila Singh, Gail T. Arce & Abraham Nyska. (2010) Carcinogenic mode of action of folpet in mice and evaluation of its relevance to humans. Critical Reviews in Toxicology 40:6, pages 531-545.
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Douglas McGregor, Alan Boobis, Marco Binaglia, Phil Botham, Laurence Hoffstadt, Sue Hubbard, Thomas Petry, Anthony Riley, Dirk Schwartz & Christa Hennes. (2010) Guidance for the classification of carcinogens under the Globally Harmonised System of Classification and Labelling of Chemicals (GHS). Critical Reviews in Toxicology 40:3, pages 245-285.
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M.E. (Bette) Meek, Leonard
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M. F. Arnold & Daniel Krewski. (2010) Risk Assessment Practice for Essential Metals. Journal of Toxicology and Environmental Health, Part A 73:2-3, pages 253-260.
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Richard Billington, Richard W. Lewis, Jyotigna M. Mehta & Ian Dewhurst. (2010) The mouse carcinogenicity study is no longer a scientifically justifiable core data requirement for the safety assessment of pesticides. Critical Reviews in Toxicology 40:1, pages 35-49.
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, AlanR. Boobis, StephenS. Olin & The ILSI Research Foundation Threshold Working Group. (2009) The Key Events Dose-Response Framework: A Cross-Disciplinary Mode-of-Action Based Approach to Examining Dose-Response and Thresholds. Critical Reviews in Food Science and Nutrition 49:8, pages 682-689.
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AlanR. Boobis, GeorgeP. Daston, R.
Julian Preston & StephenS. Olin. (2009) Application of Key Events Analysis to Chemical Carcinogens and Noncarcinogens. Critical Reviews in Food Science and Nutrition 49:8, pages 690-707.
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B. G. Lake. (2009) Species differences in the hepatic effects of inducers of CYP2B and CYP4A subfamily forms: relationship to rodent liver tumour formation. Xenobiotica 39:8, pages 582-596.
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Jaime Kapitulnik, Olavi Pelkonen, Ursula Gundert-Remy, Svein G Dahl & Alan R Boobis. (2009) Effects of pharmaceuticals and other active chemicals at biological targets: mechanisms, interactions, and integration into PB-PK/PD models. Expert Opinion on Therapeutic Targets 13:7, pages 867-887.
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Thomas G. Osimitz & Brian G. Lake. (2009) Mode-of-action analysis for induction of rat liver tumors by pyrethrins: relevance to human cancer risk. Critical Reviews in Toxicology 39:6, pages 501-511.
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Lisa M. Sweeney, Christopher R. Kirman, Richard J. Albertini, Yu-Mei Tan, Harvey J. Clewell$suffix/text()$suffix/text(), Johannes G. Filser, György Csanády, Lynn H. Pottenger, Marcy I. Banton, Cynthia J. Graham, Larry S. Andrews, Raymond J. Papciak & Michael L. Gargas. (2009) Derivation of inhalation toxicity reference values for propylene oxide using mode of action analysis: Example of a threshold carcinogen. Critical Reviews in Toxicology 39:6, pages 462-486.
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Gordon C. Hard, Kent J. Johnson & Samuel M. Cohen. (2009) A comparison of rat chronic progressive nephropathy with human renal disease—implications for human risk assessment. Critical Reviews in Toxicology 39:4, pages 332-346.
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D. Hattis, M. Chu, N. Rahmioglu, R. Goble, P. Verma, K. Hartman & M. Kozlak. (2009) A Preliminary Operational Classification System for Nonmutagenic Modes of Action for Carcinogenesis. Critical Reviews in Toxicology 39:2, pages 97-138.
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Petito Boyce, AriS. Lewis, SonjaN. Sax, Michal Eldan, SamuelM. Cohen & BarbaraD. Beck. (2008) Probabilistic Analysis of Human Health Risks Associated with Background Concentrations of Inorganic Arsenic: Use of a Margin of Exposure Approach. Human and Ecological Risk Assessment: An International Journal 14:6, pages 1159-1201.
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M. E. (Bette) Meek, Sir Colin Berry, AlanR. Boobis, SamuelM. Cohen, Margaret Hartley, Sharon Munn, Stephen Olin, Josef Schlatter & Carolyn Vickers. (2008) Re: Guyton, Kathryn Z., Barone, Stanley, Jr., Brown, Rebecca C., Euling, Susan Y., Jinot, Jennifer, Makris, Susan (2008). Mode of Action Frameworks: A Critical Analysis. Journal of Toxicology and Environmental Health, Part B, 11(1): 16–31. Journal of Toxicology and Environmental Health, Part B 11:8, pages 681-685.
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Christina Rudén & Sven Ove Hansson. (2008) Evidence-Based Toxicology: “Sound Science” in New Disguise. International Journal of Occupational and Environmental Health 14:4, pages 299-306.
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Antero Aitio. (2008) Research Needs for Environmental Health Risk Assessment. Journal of Toxicology and Environmental Health, Part A 71:18, pages 1254-1258.
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Lewis L. Smith, Robert L. Brent, Samuel M. Cohen, Nancy G. Doerrer, Jay I. Goodman, Helmut Greim, Michael P. Holsapple & Ruth M. Lightfoot. (2008) Predicting Future Human and Environmental Health Challenges: The Health and Environmental Sciences Institute's Scientific Mapping Exercise. Critical Reviews in Toxicology 38:10, pages 817-845.
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Douglas McGregor. (2007) Hydroquinone: An Evaluation of the Human Risks from its Carcinogenic and Mutagenic Properties. Critical Reviews in Toxicology 37:10, pages 887-914.
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Vicki L. Dellarco, Douglas McGregor, Sir Colin Berry, Samuel M. Cohen & Alan R. Boobis. (2006) Thiazopyr and Thyroid Disruption: Case Study Within the Context of the 2006 IPCS Human Relevance Framework for Analysis of a Cancer Mode of Action. Critical Reviews in Toxicology 36:10, pages 793-801.
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