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Akke Bakker, Remko Zweije, H. Petra Kok, Lukas J. A. Stalpers, G. Henrike Westerveld, Karel A. Hinnen, Geertjan van Tienhoven, M. Willemijn Kolff & Hans Crezee. (2022) Comparison of the clinical performance of a hybrid Alba 4D and the AMC-4 locoregional hyperthermia systems. International Journal of Hyperthermia 39:1, pages 1408-1414.
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Massimiliano Zanoli & Hana Dobšíček Trefná. (2022) The hot-to-cold spot quotient for SAR-based treatment planning in deep microwave hyperthermia. International Journal of Hyperthermia 39:1, pages 1421-1439.
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H. P. Kok & J. Crezee. (2022) Validation and practical use of Plan2Heat hyperthermia treatment planning for capacitive heating. International Journal of Hyperthermia 39:1, pages 952-966.
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H. Petra Kok & Johannes Crezee. (2022) Adapt2Heat: treatment planning-assisted locoregional hyperthermia by on-line visualization, optimization and re-optimization of SAR and temperature distributions. International Journal of Hyperthermia 39:1, pages 265-277.
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Ioannis Androulakis, Rob M. C. Mestrom, Miranda E. M. C. Christianen, Inger-Karine K. Kolkman-Deurloo & Gerard C. van Rhoon. (2021) Design of the novel ThermoBrachy applicators enabling simultaneous interstitial hyperthermia and high dose rate brachytherapy. International Journal of Hyperthermia 38:1, pages 1660-1671.
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Margarethus M. Paulides, Dario B. Rodrigues, Gennaro G. Bellizzi, Kemal Sumser, Sergio Curto, Esra Neufeld, Hazael Montanaro, H. Petra Kok & Hana Dobsicek Trefna. (2021) ESHO benchmarks for computational modeling and optimization in hyperthermia therapy. International Journal of Hyperthermia 38:1, pages 1425-1442.
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Sri Kamal Kandala, Anirudh Sharma, Sahar Mirpour, Eleni Liapi, Robert Ivkov & Anilchandra Attaluri. (2021) Validation of a coupled electromagnetic and thermal model for estimating temperatures during magnetic nanoparticle hyperthermia. International Journal of Hyperthermia 38:1, pages 611-622.
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Jacek Nadobny, Amanda Lim, Georg Seifert, Dennis Sullivan, Benjamin Chrzon, Mirko Weihrauch, Sebastian Zschaeck, Enrico Herz, Aleksandra Moczynska, Ruben Pellicer-Guridi, Peter Wust, Marcus Beck & Pirus Ghadjar. (2021) Improved patient-specific hyperthermia planning based on parametrized electromagnetic and thermal models for the SIGMA-30 applicator. International Journal of Hyperthermia 38:1, pages 663-678.
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H. P. Kok, J. van der Zee, F. Navarro Guirado, A. Bakker, N. R. Datta, S. Abdel-Rahman, M. Schmidt, P. Wust & J. Crezee. (2021) Treatment planning facilitates clinical decision making for hyperthermia treatments. International Journal of Hyperthermia 38:1, pages 532-551.
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Astrid van der Horst, H. Petra Kok & Johannes Crezee. (2021) Effect of gastrointestinal gas on the temperature distribution in pancreatic cancer hyperthermia treatment planning. International Journal of Hyperthermia 38:1, pages 229-240.
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Daan R. Löke, Roxan F. C. P. A. Helderman, Hans M. Rodermond, Pieter J. Tanis, Geert J. Streekstra, Nicolaas A. P. Franken, Arlene L. Oei, Johannes Crezee & H. Petra Kok. (2021) Demonstration of treatment planning software for hyperthermic intraperitoneal chemotherapy in a rat model. International Journal of Hyperthermia 38:1, pages 38-54.
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Jinao Zhang, Nha-Dat Bui, Wa Cheung, Stuart K. Roberts & Sunita Chauhan. (2020) Fast computation of desired thermal dose: Application to focused ultrasound-induced lesion planning. Numerical Heat Transfer, Part A: Applications 77:6, pages 666-682.
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Soraya Gavazzi, Astrid L. H. M. W. van Lier, Cornel Zachiu, Eric Jansen, Jan J. W Lagendijk, Lukas J. A Stalpers, Hans Crezee & H. Petra Kok. (2020) Advanced patient-specific hyperthermia treatment planning. International Journal of Hyperthermia 37:1, pages 992-1007.
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H. Petra Kok, Marcus Beck, Daan R. Löke, Roxan F. C. P. A. Helderman, Geertjan van Tienhoven, Pirus Ghadjar, Peter Wust & Hans Crezee. (2020) Locoregional peritoneal hyperthermia to enhance the effectiveness of chemotherapy in patients with peritoneal carcinomatosis: a simulation study comparing different locoregional heating systems. International Journal of Hyperthermia 37:1, pages 76-88.
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Jinao Zhang, Jeremy Hills, Yongmin Zhong, Bijan Shirinzadeh, Julian Smith & Chengfan Gu. (2019) Modeling of soft tissue thermal damage based on GPU acceleration. Computer Assisted Surgery 24:sup1, pages 5-12.
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Jinao Zhang & Sunita Chauhan. (2019) Real-time computation of bio-heat transfer in the fast explicit dynamics finite element algorithm (FED-FEM) framework. Numerical Heat Transfer, Part B: Fundamentals 75:4, pages 217-238.
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Peter Wust, Pirus Ghadjar, Jacek Nadobny, Marcus Beck, David Kaul, Lukas Winter & Sebastian Zschaeck. (2019) Physical analysis of temperature-dependent effects of amplitude-modulated electromagnetic hyperthermia. International Journal of Hyperthermia 36:1, pages 1245-1253.
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Kemal Sumser, Esra Neufeld, René F. Verhaart, Valerio Fortunati, Gerda M. Verduijn, Tomas Drizdal, Theo van Walsum, Jifke F. Veenland & Margarethus M. Paulides. (2019) Feasibility and relevance of discrete vasculature modeling in routine hyperthermia treatment planning. International Journal of Hyperthermia 36:1, pages 800-810.
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B. Aklan, B. Zilles, P. Paprottka, K. Manz, M. Pfirrmann, M. Santl, S. Abdel-Rahman & L. H. Lindner. (2019) Regional deep hyperthermia: quantitative evaluation of predicted and direct measured temperature distributions in patients with high-risk extremity soft-tissue sarcoma. International Journal of Hyperthermia 36:1, pages 169-184.
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G. Schooneveldt, H. P. Kok, A. Bakker, E. D. Geijsen, M. C. C. M. Hulshof, T. M. de Reijke & J. Crezee. (2018) The effect of air pockets in the urinary bladder on the temperature distribution during loco-regional hyperthermia treatment of bladder cancer patients. International Journal of Hyperthermia 35:1, pages 441-449.
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Gerben Schooneveldt, H. Petra Kok, Akke Bakker, Elisabeth D. Geijsen, Coen R. N. Rasch, Jean J. M. C. H. de la Rosette, Maarten C. C. M. Hulshof, Theo M. de Reijke & Hans Crezee. (2018) Clinical validation of a novel thermophysical bladder model designed to improve the accuracy of hyperthermia treatment planning in the pelvic region. International Journal of Hyperthermia 35:1, pages 383-397.
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H. P. Kok, G. Schooneveldt, A. Bakker, R. de Kroon-Oldenhof, L. Korshuize-van Straten, C. E. de Jong, E. Steggerda-Carvalho, E. D. Geijsen, L. J. A. Stalpers & J. Crezee. (2018) Predictive value of simulated SAR and temperature for changes in measured temperature after phase-amplitude steering during locoregional hyperthermia treatments. International Journal of Hyperthermia 35:1, pages 330-339.
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C. M. van Leeuwen, J. Crezee, A. L. Oei, N. A. P. Franken, L. J. A. Stalpers, A. Bel & H. P. Kok. (2018) The effect of time interval between radiotherapy and hyperthermia on planned equivalent radiation dose. International Journal of Hyperthermia 34:7, pages 901-909.
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Astrid van der Horst, Eva Versteijne, Marc G. H. Besselink, Joost G. Daams, Esther B. Bulle, Maarten F. Bijlsma, Johanna W. Wilmink, Otto M. van Delden, Jeanin E. van Hooft, Nicolaas A. P. Franken, Hanneke W. M. van Laarhoven, Johannes Crezee & Geertjan van Tienhoven. (2018) The clinical benefit of hyperthermia in pancreatic cancer: a systematic review. International Journal of Hyperthermia 34:7, pages 969-979.
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H. P. Kok, L. Korshuize-van Straten, A. Bakker, R. de Kroon – Oldenhof, G. H. Westerveld, E. Versteijne, L. J. A. Stalpers & J. Crezee. (2018) Feasibility of on-line temperature-based hyperthermia treatment planning to improve tumour temperatures during locoregional hyperthermia. International Journal of Hyperthermia 34:7, pages 1082-1091.
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H. P. Kok, F. Navarro, L. Strigari, M. Cavagnaro & J. Crezee. (2018) Locoregional hyperthermia of deep-seated tumours applied with capacitive and radiative systems: a simulation study. International Journal of Hyperthermia 34:6, pages 714-730.
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Paul Southern & Quentin A. Pankhurst. (2018) Commentary on the clinical and preclinical dosage limits of interstitially administered magnetic fluids for therapeutic hyperthermia based on current practice and efficacy models. International Journal of Hyperthermia 34:6, pages 671-686.
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C. M. van Leeuwen, A. L. Oei, R. ten Cate, N. A. P. Franken, A. Bel, L. J. A. Stalpers, J. Crezee & H. P. Kok. (2018) Measurement and analysis of the impact of time-interval, temperature and radiation dose on tumour cell survival and its application in thermoradiotherapy plan evaluation. International Journal of Hyperthermia 34:1, pages 30-38.
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Fu Fan, Lei Chen, Yu Zhou & Huigao Duan. (2024) Multiscale Transfer Printing via Shape Memory Polymer with High Adhesion and Modulus Switchability. ACS Applied Materials & Interfaces 16:20, pages 26824-26832.
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Jort A Groen, Johannes Crezee, Hanneke W M van Laarhoven, Bram F Coolen, Gustav J Strijkers, Maarten F Bijlsma & H Petra Kok. (2024) Robust, planning-based targeted locoregional tumour heating in small animals. Physics in Medicine & Biology 69:8, pages 085017.
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Jakob Ödén, Kjell Eriksson, Brando Pavoni, Hans Crezee & H. Petra Kok. (2024) A Novel Framework for Thermoradiotherapy Treatment Planning. International Journal of Radiation Oncology*Biology*Physics.
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Iva VilasBoas-Ribeiro, Kemal Sumser, Sven Nouwens, Theresa Feddersen, W.P.M.H. Heemels, Gerard C. van Rhoon & Margarethus M. Paulides. (2024) Adapting Temperature Predictions to MR Imaging in Treatment Position to Improve Simulation-Guided Hyperthermia for Cervical Cancer. IEEE Open Journal of Engineering in Medicine and Biology 5, pages 99-106.
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Pammi Raj Gupta, Pradyumna Ghosh & Jahar Sarkar. (2023) Effects of probe parameters on radio-frequency ablation of localized liver cancer using a personalized patient treatment planning. Thermal Science and Engineering Progress 46, pages 102236.
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G. Nandhini & M. K. Shobana. (2022) Influence of phytochemicals with iron oxide nanoparticles for biomedical applications: a review. Polymer Bulletin 80:11, pages 11715-11758.
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Jort A. Groen, Johannes Crezee, Hanneke W.M. van Laarhoven, Maarten F. Bijlsma & H. Petra Kok. (2023) Quantification of tissue property and perfusion uncertainties in hyperthermia treatment planning: Multianalysis using polynomial chaos expansion. Computer Methods and Programs in Biomedicine 240, pages 107675.
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Michaela Cerna & Tomas Drizdal. (2023) Implementation of Time Reversal Focusing on Hyperthermia Treatment of Brain Tumours. Implementation of Time Reversal Focusing on Hyperthermia Treatment of Brain Tumours.
Nandita Saha, Andre Kuehne, Jason M. Millward, Thomas Wilhelm Eigentler, Ludger Starke, Sonia Waiczies & Thoralf Niendorf. (2023) Advanced Radio Frequency Applicators for Thermal Magnetic Resonance Theranostics of Brain Tumors. Cancers 15:8, pages 2303.
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Diana Alves, Joana C. Araújo, Raul Fangueiro & Diana P. Ferreira. (2023) Localized Therapeutic Approaches Based on Micro/Nanofibers for Cancer Treatment. Molecules 28:7, pages 3053.
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H. Petra Kok, Timoteo D. Herrera & Johannes Crezee. (2023) The Relevance of High Temperatures and Short Time Intervals Between Radiation Therapy and Hyperthermia: Insights in Terms of Predicted Equivalent Enhanced Radiation Dose. International Journal of Radiation Oncology*Biology*Physics 115:4, pages 994-1003.
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Zhihua Liu, Zhirong Liao, Dong Wang, Chengyong Wang, Chengli Song, Haonan Li & Yao Liu. (2022) Recent Advances in Soft Biological Tissue Manipulating Technologies. Chinese Journal of Mechanical Engineering 35:1.
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Carlos E. Guerra-Londono, Carlos G. Tarazona, J. A. Sánchez-Monroy, Olivia Heppell, Juan J. Guerra-Londono & Rupen Shah. (2022) The Role of Hyperthermia in the Treatment of Peritoneal Surface Malignancies. Current Oncology Reports 24:7, pages 875-887.
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Ioannis Androulakis, Rob M. C. Mestrom, Miranda E. M. C. Christianen, Inger-Karine K. Kolkman-Deurloo & Gerard C. van Rhoon. (2022) A Novel Framework for the Optimization of Simultaneous ThermoBrachyTherapy. Cancers 14:6, pages 1425.
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Marloes IJff, Johannes Crezee, Arlene L Oei, Lukas J A Stalpers & Henrike Westerveld. (2022) The role of hyperthermia in the treatment of locally advanced cervical cancer: a comprehensive review. International Journal of Gynecologic Cancer 32:3, pages 288-296.
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Ioannis Androulakis, Rob M. C. Mestrom, Miranda E. M. C. Christianen, Inger-Karine K. Kolkman-Deurloo & Gerard C. van Rhoon. (2022) Simultaneous ThermoBrachytherapy: Electromagnetic Simulation Methods for Fast and Accurate Adaptive Treatment Planning. Sensors 22:4, pages 1328.
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Pierre Agnass, Krijn P. van Lienden, Thomas M. van Gulik, Marc G. Besselink, Johannes Crezee & H. Petra Kok. (2022) Improving Prediction of the Potential Distribution Induced by Cylindrical Electrodes within a Homogeneous Rectangular Grid during Irreversible Electroporation. Applied Sciences 12:3, pages 1471.
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Sun-Young Lee & Andras Szasz. 2022.
H. Petra Kok & Johannes Crezee. (2021) Fast Adaptive Temperature-Based Re-Optimization Strategies for On-Line Hot Spot Suppression during Locoregional Hyperthermia. Cancers 14:1, pages 133.
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Massimiliano Zanoli & Hana Dobšíček Trefná. (2021) Suitability of eigenvalue beam‐forming for discrete multi‐frequency hyperthermia treatment planning. Medical Physics 48:11, pages 7410-7426.
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H. Petra Kok & Johannes Crezee. (2021) Hyperthermia Treatment Planning: Clinical Application and Ongoing Developments. IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology 5:3, pages 214-222.
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Matteo Bruno Lodi, Giacomo Muntoni, Alessandro Ruggeri, Alessandro Fanti, Giorgio Montisci & Giuseppe Mazzarella. (2021) Towards the Robust and Effective Design of Hyperthermic Devices: Improvement of a Patch Antenna for the Case Study of Abdominal Rhabdomyosarcoma With 3D Perfusion. IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology 5:3, pages 197-205.
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Michael Hader, Simon Streit, Andreas Rosin, Thorsten Gerdes, Martin Wadepohl, Sander Bekeschus, Rainer Fietkau, Benjamin Frey, Eberhard Schlücker, Stephan Gekle & Udo S. Gaipl. (2021) In Vitro Examinations of Cell Death Induction and the Immune Phenotype of Cancer Cells Following Radiative-Based Hyperthermia with 915 MHz in Combination with Radiotherapy. Cells 10:6, pages 1436.
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Osamu Shimomura, Tatsuya Oda, Shinji Hashimoto, Manami Doi, Yuichi Hiroshima, Haruko Numajiri, Kazuhiro Takahashi, Kinji Furuya, Yoshihiro Miyazaki, Yohei Owada, Koichi Ogawa, Yusuke Ohara, Katsuji Hisakura, Yoshimasa Akashi, Tsuyoshi Enomoto & Hideyuki Sakurai. (2021) Survival impact on triple-modal strategy comprising hyperthermia, external radiation, and chemotherapy for unresectable locally advanced (UR-LA) pancreatic ductal adenocarcinoma. Surgical Oncology 37, pages 101542.
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Rafał Bielas, Bassam Jameel & Arkadiusz Józefczak. (2021) Monitoring of Pickering emulsion stability during magnetic heating using ultrasound measurements. Measurement 178, pages 109431.
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Manpreet Singh, Tulika Singh & Sanjeev Soni. (2021) Pre-operative Assessment of Ablation Margins for Variable Blood Perfusion Metrics in a Magnetic Resonance Imaging Based Complex Breast Tumour Anatomy: Simulation Paradigms in Thermal Therapies. Computer Methods and Programs in Biomedicine 198, pages 105781.
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Fabio Fanari, Lorena Mariani & Francesco Desogus. (2020) Heat Transfer Modeling in Bone Tumour Hyperthermia Induced by Hydroxyapatite Magnetic Thermo-Seeds. The Open Chemical Engineering Journal 14:1, pages 77-89.
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Soraya Gavazzi, Cornelis A. T. van den Berg, Mark H. F. Savenije, H. Petra Kok, Peter de Boer, Lukas J. A. Stalpers, Jan J. W. Lagendijk, Hans Crezee & Astrid L. H. M. W. van Lier. (2020) Deep learning‐based reconstruction of in vivo pelvis conductivity with a 3D patch‐based convolutional neural network trained on simulated MR data. Magnetic Resonance in Medicine 84:5, pages 2772-2787.
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Marta Cavagnaro & Giuseppe Ruvio. (2020) Numerical Sensitivity Analysis for Dielectric Characterization of Biological Samples by Open-Ended Probe Technique. Sensors 20:13, pages 3756.
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Niloy R. Datta, H. Petra Kok, Hans Crezee, Udo S. Gaipl & Stephan Bodis. (2020) Integrating Loco-Regional Hyperthermia Into the Current Oncology Practice: SWOT and TOWS Analyses. Frontiers in Oncology 10.
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Gerben Schooneveldt, Daan R. Löke, Remko Zweije, Roxan F.C.P.A. Helderman, H. Petra Kok & Hans Crezee. (2020) Experimental validation of a thermophysical fluid model for use in a hyperthermia treatment planning system. International Journal of Heat and Mass Transfer 152, pages 119495.
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Jinao Zhang & Sunita Chauhan. (2020) Fast computation of soft tissue thermal response under deformation based on fast explicit dynamics finite element algorithm for surgical simulation. Computer Methods and Programs in Biomedicine 187, pages 105244.
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H. Petra Kok, Jort Groen, Akke Bakker & Johannes Crezee. (2020) Modelling Curved Contact Flexible Microstrip Applicators for Patient-Specific Superficial Hyperthermia Treatment Planning. Cancers 12:3, pages 656.
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J. Crezee, R. Zweije & H.P. Kok. (2020) Loco-regional Hyperthermia Delivery: Patient-specific set-up Procedures for Treatment Optimisation. Loco-regional Hyperthermia Delivery: Patient-specific set-up Procedures for Treatment Optimisation.
Jinho Hwang, Yunji Seol, Taegeon Oh, Na young An, Jaehyeon Lee, Chul-Seung Kay, Hong Seok Jang, Byung Ock Choi & Young-nam Kang. (2020) Evaluation of Developed Thermal Distribution Prediction Algorithm Using Mass Density Distribution with CT Image. Journal of the Korean Physical Society 76:1, pages 86-92.
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M.M. Paulides, H. Dobsicek Trefna, S. Curto & D.B. Rodrigues. (2020) Recent technological advancements in radiofrequency- andmicrowave-mediated hyperthermia for enhancing drug delivery. Advanced Drug Delivery Reviews 163-164, pages 3-18.
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Azadeh Shahidian, Majid Ghassemi, Javad Mohammadi & Mohadeseh Hashemi. 2020. Bio-Engineering Approaches to Cancer Diagnosis and Treatment. Bio-Engineering Approaches to Cancer Diagnosis and Treatment
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Jinao Zhang & Sunita Chauhan. (2019) Neural network methodology for real-time modelling of bio-heat transfer during thermo-therapeutic applications. Artificial Intelligence in Medicine 101, pages 101728.
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Bibin Prasad, Jung Kyung Kim & Suzy Kim. (2019) Role of Simulations in the Treatment Planning of Radiofrequency Hyperthermia Therapy in Clinics. Journal of Oncology 2019, pages 1-12.
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Gerben Schooneveldt, Hana Dobšíček Trefná, Mikael Persson, Theo M. de Reijke, Klas Blomgren, H. Petra Kok & Hans Crezee. (2019) Hyperthermia Treatment Planning Including Convective Flow in Cerebrospinal Fluid for Brain Tumour Hyperthermia Treatment Using a Novel Dedicated Paediatric Brain Applicator. Cancers 11:8, pages 1183.
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Soraya Gavazzi, Cornelis A.T. van den Berg, Alessandro Sbrizzi, H. Petra Kok, Lukas J. A. Stalpers, Jan J.W. Lagendijk, Hans Crezee & Astrid L. H. M. W. van Lier. (2019) Accuracy and precision of electrical permittivity mapping at 3T: the impact of three mapping techniques. Magnetic Resonance in Medicine 81:6, pages 3628-3642.
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Bibin Prasad, Subin Kim, Woong Cho, Jung Kyung Kim, Young A. Kim, Suzy Kim & Hong Gyun Wu. (2019) Quantitative Estimation of the Equivalent Radiation Dose Escalation using Radiofrequency Hyperthermia in Mouse Xenograft Models of Human Lung Cancer. Scientific Reports 9:1.
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Rohan Dhavalikar, Ana C. Bohórquez & Carlos Rinaldi. 2019. Nanomaterials for Magnetic and Optical Hyperthermia Applications. Nanomaterials for Magnetic and Optical Hyperthermia Applications
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H. Petra Kok, Irma Van Dijk, Koen Crama, Nicolaas Franken, Coen Rasch, Johannes Merks, Johannes Crezee, Brian Balgobind & Arjan Bel. (2018) Re‑irradiation plus hyperthermia for recurrent pediatric sarcoma; a simulation study to investigate feasibility. International Journal of Oncology.
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Jinho Hwang, Aeran Kim, Jina Kim, Yunji Seol, Taegeon Oh, Jin-sol Shin, Hong Seok Jang, Yeon Sil Kim, Byung Ock Choi & Young-nam Kang. (2018) Development of an Algorithm for Predicting the Thermal Distribution by using CT Image and the Specific Absorption Rate. Journal of the Korean Physical Society 73:10, pages 1584-1588.
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H.P. Kok, R. de Kroon - Oldenhof, L. Korshuize van Straten, C.E. de Jong, A. Bakker, R. Zweije, J. Sijbrands, G. van Tienhoven & J. Crezee. (2018) RF Heating of Pancreatic Tumours Guided by Hyperthermia Treatment Planning and Limited Thermometry. RF Heating of Pancreatic Tumours Guided by Hyperthermia Treatment Planning and Limited Thermometry.
Bibin Prasad, Subin Kim, Woong Cho, Suzy Kim & Jung Kyung Kim. (2018) Effect of tumor properties on energy absorption, temperature mapping, and thermal dose in 13.56-MHz radiofrequency hyperthermia. Journal of Thermal Biology 74, pages 281-289.
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H. Petra Kok, Linda Korshuize- van Straten, Akke Bakker, Rianne de Kroon- Oldenhof, Elisabeth D. Geijsen, Lukas J.A. Stalpers & Johannes Crezee. (2017) Online Adaptive Hyperthermia Treatment Planning During Locoregional Heating to Suppress Treatment-Limiting Hot Spots. International Journal of Radiation Oncology*Biology*Physics 99:4, pages 1039-1047.
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Emiliano Schena, Paola Saccomandi & Yuman Fong. (2017) Laser Ablation for Cancer: Past, Present and Future. Journal of Functional Biomaterials 8:2, pages 19.
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Qi Baoning, Shi Chuandao, Sun Na, Xinan Wang & Han Yuanping. (2017) Efficacy and safety of radio-chemotherapy combined with thermotherapy for advanced cervical cancer in Chinese women: a meta-analysis. Archives of Medical Science – Civilization Diseases 2:1, pages 182-190.
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