Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 30, Issue 6 (2015)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 30, Issue 6 (2015)

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Review Article

High-efficient synthesis and biological activities of allosamidins
Gangliang Huang, Daquan Peng, Xinya Mei, Xin Chen, Feng Xiao & Qilin Tang
Pages: 863-866
Published online: 08 Dec 2014
AbstractforHigh-efficient synthesis and biological activities of allosamidins | Full Text | References | PDF (263.8 KB)
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Research Article

Article
Perturbation response scanning specifies key regions in subtilisin serine protease for both function and stability
Haleh Abdizadeh, Gokce Guven, Ali Rana Atilgan & Canan Atilgan
Pages: 867-873
Published online: 03 Feb 2015
AbstractforPerturbation response scanning specifies key regions in subtilisin serine protease for both function and stability | Full Text | References | PDF (454.2 KB)
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Article
Design, synthesis and bioevaluation of novel umbelliferone analogues as potential mushroom tyrosinase inhibitors
Zaman Ashraf, Muhammad Rafiq, Sung-Yum Seo, Mustafeez Mujtaba Babar & Najam-us-Sahar Sadaf Zaidi
Pages: 874-883
Published online: 03 Feb 2015
AbstractforDesign, synthesis and bioevaluation of novel umbelliferone analogues as potential mushroom tyrosinase inhibitors | Full Text | References | PDF (1.6 MB)
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Article
Design and synthesis of resveratrol–salicylate hybrid derivatives as CYP1A1 inhibitors
Fahad S. Aldawsari, Osama H. Elshenawy, Mohamed A. M. El Gendy, Rodrigo Aguayo-Ortiz, Shairaz Baksh, Ayman O. S. El-Kadi & Carlos A. Velázquez-Martínez
Pages: 884-895
Published online: 19 Nov 2014
AbstractforDesign and synthesis of resveratrol–salicylate hybrid derivatives as CYP1A1 inhibitors | Full Text | References | PDF (1.4 MB)
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Article
Synthesis of 3,4-dihydroxypyrrolidine-2,5-dione and 3,5-dihydroxybenzoic acid derivatives and evaluation of the carbonic anhydrase I and II inhibition
Mehmet Arslan, Murat Şentürk, İsmail Fidan, Oktay Talaz, Deniz Ekinci, Sedat Coşgun & Claudiu T. Supuran
Pages: 896-900
Published online: 06 Mar 2015
AbstractforSynthesis of 3,4-dihydroxypyrrolidine-2,5-dione and 3,5-dihydroxybenzoic acid derivatives and evaluation of the carbonic anhydrase I and II inhibition | Full Text | References | PDF (257.3 KB)
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Article
Inhibition of carbonic anhydrase isoforms I, II, IX and XII with Schiff’s bases incorporating iminoureido moieties
Namrata Singasane, Prashant S. Kharkar, Mariangela Ceruso, Claudiu T. Supuran & Mrunmayee P. Toraskar
Pages: 901-907
Published online: 06 Mar 2015
AbstractforInhibition of carbonic anhydrase isoforms I, II, IX and XII with Schiff’s bases incorporating iminoureido moieties | Full Text | References | PDF (257.1 KB) | Supplemental
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Article
(Thiazol-2-yl)hydrazone derivatives from acetylpyridines as dual inhibitors of MAO and AChE: synthesis, biological evaluation and molecular modeling studies
Melissa D’Ascenzio, Paola Chimenti, Maria Concetta Gidaro, Celeste De Monte, Daniela De Vita, Arianna Granese, Luigi Scipione, Roberto Di Santo, Giosuè Costa, Stefano Alcaro, Matilde Yáñez & Simone Carradori
Pages: 908-919
Published online: 25 Mar 2015
Abstractfor(Thiazol-2-yl)hydrazone derivatives from acetylpyridines as dual inhibitors of MAO and AChE: synthesis, biological evaluation and molecular modeling studies | Full Text | References | PDF (871.1 KB) | Supplemental
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Article
Protonography, a technique applicable for the analysis of η-carbonic anhydrase activity
Sonia Del Prete, Viviana De Luca, Claudiu T. Supuran & Clemente Capasso
Pages: 920-924
Published online: 13 Feb 2015
AbstractforProtonography, a technique applicable for the analysis of η-carbonic anhydrase activity | Full Text | References | PDF (343 KB)
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Article
Studies on the antiplatelet and antithrombotic profile of anti-inflammatory coumarin derivatives
Christos Kontogiorgis, Orazio Nicolotti, Giuseppe Felice Mangiatordi, Massimiliano Tognolini, Foteini Karalaki, Carmine Giorgio, Alexandros Patsilinakos, Angelo Carotti, Dimitra Hadjipavlou-Litina & Elisabetta Barocelli
Pages: 925-933
Published online: 25 Mar 2015
AbstractforStudies on the antiplatelet and antithrombotic profile of anti-inflammatory coumarin derivatives | Full Text | References | PDF (1.4 MB) | Supplemental
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Article
Chemical constituents of Hericium erinaceum associated with the inhibitory activity against cellular senescence in human umbilical vascular endothelial cells
Hyung Jun Noh, Hyo Hyun Yang, Geum Soog Kim, Seung Eun Lee, Dae Young Lee, Je Hun Choi, Seung Yu Kim, Eun Suk Lee, Seung Heon Ji, Ki Sung Kang, Hye-Jin Park, Jae-Ryong Kim & Ki Hyun Kim
Pages: 934-940
Published online: 13 Feb 2015
AbstractforChemical constituents of Hericium erinaceum associated with the inhibitory activity against cellular senescence in human umbilical vascular endothelial cells | Full Text | References | PDF (518 KB)
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Article
The impact of hydroquinone on acetylcholine esterase and certain human carbonic anhydrase isoenzymes (hCA I, II, IX, and XII)
Andrea Scozzafava, Pınar Kalın, Claudiu T. Supuran, İlhami Gülçin & Saleh H. Alwasel
Pages: 941-946
Published online: 14 Jan 2015
AbstractforThe impact of hydroquinone on acetylcholine esterase and certain human carbonic anhydrase isoenzymes (hCA I, II, IX, and XII) | Full Text | References | PDF (276 KB)
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Article
Kinetic characterization of 4,4′-biphenylsulfonamides as selective non-zinc binding MMP inhibitors
Salvatore Santamaria, Elisa Nuti, Giovanni Cercignani, Giuseppe La Regina, Romano Silvestri, Claudiu T. Supuran & Armando Rossello
Pages: 947-954
Published online: 19 Feb 2015
AbstractforKinetic characterization of 4,4′-biphenylsulfonamides as selective non-zinc binding MMP inhibitors | Full Text | References | PDF (762 KB)
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Article
Esterase activity of carbonic anhydrases serves as surrogate for selecting antibodies blocking hydratase activity
Narasimha Rao Uda, Volker Seibert, Frank Stenner-Liewen, Philipp Müller, Petra Herzig, Gabor Gondi, Reinhard Zeidler, Marc van Dijk, Alfred Zippelius & Christoph Renner
Pages: 955-960
Published online: 16 Mar 2015
AbstractforEsterase activity of carbonic anhydrases serves as surrogate for selecting antibodies blocking hydratase activity | Full Text | References | PDF (538.6 KB) | Supplemental
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Article
Synthesis and evaluation of biological and antitumor activities of 5,7-dimethyl- oxazolo[5,4-d]pyrimidine-4,6(5H,7H)-dione derivatives as novel inhibitors of FGFR1
Faqing Ye, Yuewu Wang, Siyun Nian, Yu Wang, Di Chen, Shufang Yu & Sicen Wang
Pages: 961-966
Published online: 16 Feb 2015
AbstractforSynthesis and evaluation of biological and antitumor activities of 5,7-dimethyl- oxazolo[5,4-d]pyrimidine-4,6(5H,7H)-dione derivatives as novel inhibitors of FGFR1 | Full Text | References | PDF (587.1 KB)
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Article
Synthesis of pro-apoptotic indapamide derivatives as anticancer agents
Özgür Yılmaz, Suna Özbaş Turan, Jülide Akbuğa, Pınar Mega Tiber, Oya Orun, Claudiu T. Supuran & Ş. Güniz Küçükgüzel
Pages: 967-980
Published online: 16 Feb 2015
AbstractforSynthesis of pro-apoptotic indapamide derivatives as anticancer agents | Full Text | References | PDF (2.4 MB) | Supplemental
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Article
Anagliptin, a potent dipeptidyl peptidase IV inhibitor: its single-crystal structure and enzyme interactions
Yukihisa S. Watanabe, Yoshika Yasuda, Yuko Kojima, Shino Okada, Tomoko Motoyama, Ryo Takahashi & Mitsuru Oka
Pages: 981-988
Published online: 06 Jul 2015
AbstractforAnagliptin, a potent dipeptidyl peptidase IV inhibitor: its single-crystal structure and enzyme interactions | Full Text | References | PDF (921.9 KB)
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Article
A failed tentative to design a super carbonic anhydrase having the biochemical properties of the most thermostable CA (SspCA) and the fastest (SazCA) enzymes
Viviana De Luca, Sonia Del Prete, Vincenzo Carginale, Daniela Vullo, Claudiu T. Supuran & Clemente Capasso
Pages: 989-994
Published online: 16 Feb 2015
AbstractforA failed tentative to design a super carbonic anhydrase having the biochemical properties of the most thermostable CA (SspCA) and the fastest (SazCA) enzymes | Full Text | References | PDF (306.1 KB)
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Article
Tacrine–propargylamine derivatives with improved acetylcholinesterase inhibitory activity and lower hepatotoxicity as a potential lead compound for the treatment of Alzheimer’s disease
Fei Mao, Jianheng Li, Hui Wei, Ling Huang & Xingshu Li
Pages: 995-1001
Published online: 20 Mar 2015
AbstractforTacrine–propargylamine derivatives with improved acetylcholinesterase inhibitory activity and lower hepatotoxicity as a potential lead compound for the treatment of Alzheimer’s disease | Full Text | References | PDF (887.5 KB)
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Article
Synthesis of some novel heterocylic compounds derived from 2-[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol-4-yl]acetohydrazide and investigation of their lipase and α-glucosidase inhibition
Olcay Bekircan, Serdar Ülker & Emre Menteşe
Pages: 1002-1009
Published online: 02 Feb 2015
AbstractforSynthesis of some novel heterocylic compounds derived from 2-[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol-4-yl]acetohydrazide and investigation of their lipase and α-glucosidase inhibition | Full Text | References | PDF (266 KB)
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Short Communication

Rapid Communication
N-glycosyl-N-hydroxysulfamides as potent inhibitors of Brucella suis carbonic anhydrases
Joanna Ombouma, Daniela Vullo, Stephan Köhler, Pascal Dumy, Claudiu T. Supuran & Jean-Yves Winum
Pages: 1010-1012
Published online: 20 Mar 2015
AbstractforN-glycosyl-N-hydroxysulfamides as potent inhibitors of Brucella suis carbonic anhydrases | Full Text | References | PDF (204.3 KB)
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Research Article

Rapid Communication
Production of collagen micro- and nanofibers for potential drug-carrier systems
Onur Aras & Murat Kazanci
Pages: 1013-1016
Published online: 06 Mar 2015
AbstractforProduction of collagen micro- and nanofibers for potential drug-carrier systems | Full Text | References | PDF (475.7 KB)
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Short Communication

Rapid Communication
Inhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety
Leonardo E. Riafrecha, Daniela Vullo, Safia Ouahrani-Bettache, Stephan Köhler, Pascal Dumy, Jean-Yves Winum, Claudiu T. Supuran & Pedro A. Colinas
Pages: 1017-1020
Published online: 13 Feb 2015
AbstractforInhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety | Full Text | References | PDF (232.3 KB)
  • 555 Views
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Rapid Communication
Search for human DNA topoisomerase II poisons in the group of 2,5-disubstituted-1,3,4-thiadiazoles
Tomasz Plech, Barbara Kaproń, Agata Paneth, Monika Wujec, Robert Czarnomysy, Anna Bielawska, Krzysztof Bielawski, Nazar Trotsko, Edyta Kuśmierz & Piotr Paneth
Pages: 1021-1026
Published online: 20 Mar 2015
AbstractforSearch for human DNA topoisomerase II poisons in the group of 2,5-disubstituted-1,3,4-thiadiazoles | Full Text | References | PDF (213.9 KB) | Supplemental
  • 1080 Views
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Rapid Communication
Bioactive compounds of Crocus sativus L. and their semi-synthetic derivatives as promising anti-Helicobacter pylori, anti-malarial and anti-leishmanial agents
Celeste De Monte, Bruna Bizzarri, Maria Concetta Gidaro, Simone Carradori, Adriano Mollica, Grazia Luisi, Arianna Granese, Stefano Alcaro, Giosuè Costa, Nicoletta Basilico, Silvia Parapini, Maria Maddalena Scaltrito, Carla Masia & Francesca Sisto
Pages: 1027-1033
Published online: 13 Mar 2015
AbstractforBioactive compounds of Crocus sativus L. and their semi-synthetic derivatives as promising anti-Helicobacter pylori, anti-malarial and anti-leishmanial agents | Full Text | References | PDF (616.7 KB) | Supplemental
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Editorial Board

Editorial Board
Page: ebi
Published online: 29 Oct 2015
CitationforEditorial Board | Full Text | PDF (20.5 KB)
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