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Journal of Extracellular Vesicles Volume 4, 2015 - Issue 1
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Position Papers

Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper

Thomas LenerSpinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria;Department of Blood Group Serology and Transfusion MedicineUniversity Hospital, Salzburger Landeskliniken GesmbH (SALK), Salzburg, Austria
,
Mario GimonaSpinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria;Department of Blood Group Serology and Transfusion MedicineUniversity Hospital, Salzburger Landeskliniken GesmbH (SALK), Salzburg, Austria
,
Ludwig AignerSpinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria
,
Verena BörgerInstitute for Transfusion MedicineUniversity Hospital Essen, University of Duisburg-Essen, Essen, Germany
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Edit BuzasDepartment of GeneticsCell- and Immunobiology, Semmelweis University, Budapest, Hungary
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Giovanni CamussiMolecular Biotechnology CenterDepartment of Medical Sciences, University of Turin, Turin, Italy
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Nathalie ChaputLaboratory of Immunomonitoring in Oncology, UMS 3655 CNRS/US23 Inserm, Villejuif, France;Centre of Clinical Investigation in Biotherapy CICBT 1248, Institut Gustave Roussy, Villejuif, France
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Devasis ChatterjeeDivision of Hematology & Oncology, Rhode Island Hospital, Providence, RI, USA;The Alpert Medical School of Brown University Providence, RI, USA
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Felipe A. CourtDepartment of Physiology Faculty of Biology, Pontificia-Universidad Católica de Chile, Santiago, Chile
,
Hernando A. del PortilloICREA at Barcelona Centre for International Health Research (CRESIB), Hospital Clínic – Universitat de Barcelona, Barcelona, Spain;Institut d'Investigació Germans Trias i Pujol (IGTP), Badalona, Spain
,
Lorraine O'DriscollSchool of Pharmacy and Pharmaceutical SciencesTrinity College Dublin, Dublin 2, Ireland;;Trinity Biomedical Sciences Institute Trinity College Dublin, Dublin 2, Ireland
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Stefano FaisAnti-Tumor Drugs SectionDepartment of Therapeutic Research and Medicines Evaluation, National Institute of Health (ISS), Rome, Italy
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Juan M. Falcon-PerezMetabolomics Unit CIC bioGUNE, CIBERehd, Bizkaia Technology Park, Derio, Spain;IKERBASQUEBasque Foundation for Science, Bilbao, Spain
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Ursula Felderhoff-MueserDepartment of Paediatrics I Neonatology, University Hospital Essen, University Duisburg-Essen, Essen, Germany
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Lorenzo FraileDepartament de Producció Animal, ETSEA, Universitat de Lleida, Lleida, Spain
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Yong Song GhoDepartment of Life SciencesPohang University of Science and Technology, Pohang, Republic of Korea
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André GörgensInstitute for Transfusion MedicineUniversity Hospital Essen, University of Duisburg-Essen, Essen, Germany
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Ramesh C. GuptaDepartment of Pharmacology and ToxicologyUniversity of Louisville, Louisville, KY, USA;James Graham Brown Cancer CenterUniversity of Louisville, Louisville, KY, USA
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An HendrixLaboratory of Experimental Cancer Research Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium
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Dirk M. HermannDepartment of NeurologyUniversity Hospital Essen, University of Duisburg-Essen, Essen, Germany
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Andrew F. HillDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia
,
Fred HochbergMassachusetts General Hospital, Boston, MA, USA
,
Peter A. HornInstitute for Transfusion MedicineUniversity Hospital Essen, University of Duisburg-Essen, Essen, Germany
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Dominique de KleijnDepartment of SurgeryYLL School of Medicine, NUS, Singapore, Singapore
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Lambros KordelasDepartment of Bone Marrow TransplantationUniversity Hospital Essen, University of Duisburg-Essen, Essen, Germany
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Boris W. KramerExperimental Perinatology/NeonatologySchool of Mental Health and Neuroscience, School of Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands
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Eva-Maria Krämer-AlbersMolecular Cell Biology and Focus Program Translational NeurosciencesUniversity of Mainz, Mainz, Germany
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Sandra Laner-PlambergerSpinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria;Department of Blood Group Serology and Transfusion MedicineUniversity Hospital, Salzburger Landeskliniken GesmbH (SALK), Salzburg, Austria
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Saara LaitinenResearch and Cell ServicesFinnish Red Cross Blood Service, Helsinki, Finland
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Tommaso LeonardiDivision of Stem Cell Neurobiology, Department of Clinical Neurosciences, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK;European Molecular Biology LaboratoryEuropean Bioinformatics Institute (EMBL-EBI), Cambridge, UK
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Magdalena J. LorenowiczDepartment of Cell BiologyCenter for Molecular Medicine, University Medical Center, Utrecht, The Netherlands
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Sai Kiang LimInstitute of Medical BiologyAgency for Science Technology and Research (A*STAR), Singapore, Singapore
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Jan LötvallKrefting Research Centre, Institute of Medicine, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Casey A. MaguireHarvard Medical School, Massachusetts General Hospital, Boston, MA, USA
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Antonio MarcillaDpto. Biología Celular y ParasitologiaFacultat de Farmacia, Universitat de Valencia, Valencia, Spain;Joint Research Unit on EndocrinologyNutrition and Clinical Dietetics, Universitat de València-Health Research Institute La Fe, Valencia, Spain
,
Irina NazarenkoInstitute for Environmental Health Sciences and Hospital Infection Control Medical CenterUniversity of Freiburg, Freiburg im Breisgau, Germany
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Takahiro OchiyaDivision of Molecular and Cellular MedicineNational Cancer Center Research Institute, Tokyo, Japan
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Tushar PatelDepartments of Transplantation and Cancer BiologyMayo Clinic, Jacksonville, FL, USA
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Shona PedersenCentre for Cardiovascular Research, Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg University, Aalborg, Denmark
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Gabriella PocsfalviMass Spectrometry and ProteomicsInstitute of Biosciences and BioResources, National Research Council of Italy, Naples, Italy
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Stefano PluchinoDivision of Stem Cell Neurobiology, Department of Clinical Neurosciences, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK
,
Peter QuesenberryDivision of Hematology & Oncology, Rhode Island Hospital, Providence, RI, USA;The Alpert Medical School of Brown University Providence, RI, USA
,
Ilona G. ReischlBASG – Bundesamt für Sicherheit im Gesundheitswesen – Federal Office for Safety in Health Care, AGES – Agentur für Gesundheit und Ernährungssicherheit – Austrian Agency for Health and Food Safety, Institut Überwachung – Institute Surveillance, Wien, Austria
,
Francisco J. RiveraInstitute of Molecular Regenerative MedicineSpinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria;
,
Ralf SanzenbacherRalf Sanzenbacher Paul-Ehrlich-Institut, Bundesinstitut für Impfstoffe und biomedizinische Arzneimittel, Federal Institute for Vaccines and Biomedicines, Langen, Germany
,
Katharina SchallmoserSpinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria;Department of Blood Group Serology and Transfusion MedicineUniversity Hospital, Salzburger Landeskliniken GesmbH (SALK), Salzburg, Austria
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Ineke Slaper-CortenbachCell Therapy Facility Department of Clinical Pharmacy, University Medical Center Utrecht, Utrecht, The Netherlands
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Dirk StrunkExperimental & Clinical Cell Therapy InstituteSpinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, Salzburg, Austria
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Torsten TonnInstitute for Transfusion Medicine DresdenGerman Red Cross Blood Donation Service North-East, Dresden, Germany
,
Pieter VaderLaboratory of Clinical Chemistry and HematologyUniversity Medical Center Utrecht, Utrecht, The Netherlands;Department of PhysiologyAnatomy and Genetics, University of Oxford, Oxford, UK
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Bas W. M. van BalkomDepartment of Nephrology and HypertensionUniversity Medical Center Utrecht, Utrecht, The Netherlands
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Marca WaubenDepartment of Biochemistry and Cell BiologyFaculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
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Samir El AndaloussiDepartment of PhysiologyAnatomy and Genetics, University of Oxford, Oxford, UK;Department of Laboratory MedicineKarolinska Institutet, Stockholm, Sweden
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Clotilde ThéryCentre of Clinical Investigation in Biotherapy CICBT 1248, Institut Gustave Roussy, Villejuif, France;INSERM U932 Institut Curie, Paris, France
,
Eva RohdeSpinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria;Department of Blood Group Serology and Transfusion MedicineUniversity Hospital, Salzburger Landeskliniken GesmbH (SALK), Salzburg, AustriaCorrespondence[email protected] [email protected]
&
Bernd GiebelInstitute for Transfusion MedicineUniversity Hospital Essen, University of Duisburg-Essen, Essen, GermanyCorrespondence[email protected] [email protected]
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Article: 30087 | Received 20 Oct 2015, Accepted 13 Dec 2015, Published online: 31 Dec 2015

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Jennifer Phan, Priyadarsini Kumar, Dake Hao, Kewa Gao, Diana Farmer & Aijun Wang. (2018) Engineering mesenchymal stem cells to improve their exosome efficacy and yield for cell-free therapy. Journal of Extracellular Vesicles 7:1.
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David W. Greening & Richard J. Simpson. (2018) Understanding extracellular vesicle diversity – current status. Expert Review of Proteomics 15:11, pages 887-910.
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