Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 29, Issue 6 (2014)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 29, Issue 6 (2014)

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Original Article

Article
A novel matrix metalloproteinase-2 inhibitor triazolylmethyl aziridine reduces melanoma cell invasion, angiogenesis and targets ERK1/2 phosphorylation
Nadezhda Romanchikova, Pēteris Trapencieris, Jānis Zemītis & Māris Turks
Pages: 765-772
Published online: 19 Nov 2013
AbstractforA novel matrix metalloproteinase-2 inhibitor triazolylmethyl aziridine reduces melanoma cell invasion, angiogenesis and targets ERK1/2 phosphorylation | Full Text | References | PDF (415.2 KB)
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Research Article

Article
Characterization of carbonic anhydrase from Turkish native “Gerze” chicken and influences of metal ions on enzyme activity
Levent Mercan, Deniz Ekinci & Claudiu T. Supuran
Pages: 773-776
Published online: 10 Feb 2014
AbstractforCharacterization of carbonic anhydrase from Turkish native “Gerze” chicken and influences of metal ions on enzyme activity | Full Text | References | PDF (198 KB)
  • 599 Views
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Article
Design synthesis and antibacterial activity studies of new thiadiazoloquinolone compounds
Raed A. Al-Qawasmeh, Mohammed M. Abadleh, Jalal A. Zahra, Mustafa M. El-Abadelah, Rabab Albashiti, Franca Zani, Matteo Incerti & Paola Vicini
Pages: 777-785
Published online: 10 Feb 2014
AbstractforDesign synthesis and antibacterial activity studies of new thiadiazoloquinolone compounds | Full Text | References | PDF (501.2 KB)
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Article
Synthesis, antiproliferative and antimicrobial activity of new Mannich bases bearing 1,2,4-triazole moiety
Łukasz Popiołek, Jolanta Rzymowska, Urszula Kosikowska, Anna Hordyjewska, Monika Wujec & Anna Malm
Pages: 786-795
Published online: 10 Feb 2014
AbstractforSynthesis, antiproliferative and antimicrobial activity of new Mannich bases bearing 1,2,4-triazole moiety | Full Text | References | PDF (2.9 MB)
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Article
Retinol oxidation to retinoic acid in human thyroid glandular cells
Gennaro Taibi, Maria Concetta Gueli, Concetta M. A. Nicotra, Letizia Cocciadiferro & Giuseppe Carruba
Pages: 796-803
Published online: 10 Feb 2014
AbstractforRetinol oxidation to retinoic acid in human thyroid glandular cells | Full Text | References | PDF (912 KB)
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Original Article

Article
Monoclonal antibodies raised against 167–180 aa sequence of human carbonic anhydrase XII inhibit its enzymatic activity
Dovile Dekaminaviciute, Visvaldas Kairys, Milda Zilnyte, Vilma Petrikaite, Vaida Jogaite, Jurgita Matuliene, Zivile Gudleviciene, Daniela Vullo, Claudiu T. Supuran & Aurelija Zvirbliene
Pages: 804-810
Published online: 09 Jan 2014
AbstractforMonoclonal antibodies raised against 167–180 aa sequence of human carbonic anhydrase XII inhibit its enzymatic activity | Full Text | References | PDF (1.2 MB)
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Research Article

Article
Synthesis and anticancer activity of some 1,2,3-trisubstituted pyrazinobenzimidazole derivatives
Şeref Demirayak & Leyla Yurttaş
Pages: 811-822
Published online: 24 Jan 2014
AbstractforSynthesis and anticancer activity of some 1,2,3-trisubstituted pyrazinobenzimidazole derivatives | Full Text | References | PDF (1.7 MB)
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Article
Inhibitory effect of collagen-derived tripeptides on dipeptidylpeptidase-IV activity
Tadashi Hatanaka, Kayoko Kawakami & Misugi Uraji
Pages: 823-828
Published online: 20 Mar 2014
AbstractforInhibitory effect of collagen-derived tripeptides on dipeptidylpeptidase-IV activity | Full Text | References | PDF (434.4 KB)
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Article
Polyphenol oxidase activity and antioxidant properties of Yomra apple (Malus communis L.) from Turkey
Zehra Can, Barbaros Dincer, Huseyin Sahin, Nimet Baltas, Oktay Yildiz & Sevgi Kolayli
Pages: 829-835
Published online: 19 Nov 2013
AbstractforPolyphenol oxidase activity and antioxidant properties of Yomra apple (Malus communis L.) from Turkey | Full Text | References | PDF (160.1 KB)
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Short Communications

Article
Microplate-based method to screen inhibitors of isozymes of cyclic nucleotide phosphodiesterase fused to SUMO
Chunyan Chen, Miaomiao Liu, Jing Wu, Xiaolan Yang, Xiaolei Hu, Jun Pu, Gaobo Long, Yanling Xie, Hairong Jiang, Yonghua Yuan & Fei Liao
Pages: 836-839
Published online: 11 Feb 2014
AbstractforMicroplate-based method to screen inhibitors of isozymes of cyclic nucleotide phosphodiesterase fused to SUMO | Full Text | References | PDF (193.8 KB)
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Research Article

Article
Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel cyanoenone and enone benzenesulfonamides
Mostafa M. Ghorab, Maureen Higgins, Mansour S. Alsaid, Reem K. Arafa, Abdelaaty A. Shahat & Albena T. Dinkova-Kostova
Pages: 840-845
Published online: 14 Jan 2014
AbstractforSynthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel cyanoenone and enone benzenesulfonamides | Full Text | References | PDF (862.7 KB)
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Original Article

Article
Design, synthesis and structure–activity relationship studies of novel and diverse cyclooxygenase-2 inhibitors as anti-inflammatory drugs
Shigeo Hayashi, Naomi Ueno, Akio Murase & Junji Takada
Pages: 846-867
Published online: 11 Feb 2014
AbstractforDesign, synthesis and structure–activity relationship studies of novel and diverse cyclooxygenase-2 inhibitors as anti-inflammatory drugs | Full Text | References | PDF (1.7 MB) | Supplemental
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Research Article

Article
Accounting for strain variations and resistance mutations in the characterization of hepatitis C NS3 protease inhibitors
Angelica E. Ehrenberg, Benjamin Schmuck, Muhammad Ikram Anwar, Sofia Svahn Gustafsson, Gun Stenberg & U. Helena Danielson
Pages: 868-876
Published online: 11 Feb 2014
AbstractforAccounting for strain variations and resistance mutations in the characterization of hepatitis C NS3 protease inhibitors | Full Text | References | PDF (878 KB) | Supplemental
  • 616 Views
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Article
Chemometric modeling of breast cancer associated carbonic anhydrase IX inhibitors belonging to the ureido-substituted benzene sulfonamide class
Shalini Singh & Claudiu T. Supuran
Pages: 877-883
Published online: 11 Feb 2014
AbstractforChemometric modeling of breast cancer associated carbonic anhydrase IX inhibitors belonging to the ureido-substituted benzene sulfonamide class | Full Text | References | PDF (540.3 KB) | Supplemental
  • 552 Views
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Article
Use of the harmonic mean to the determination of dissociation constants of stereoisomeric mixtures of biologically active compounds
J. Alberto Guevara-Salazar, Delia Quintana-Zavala, Hugo A. Jiménez-Vázquez & José Trujillo-Ferrara
Pages: 884-894
Published online: 11 Feb 2014
AbstractforUse of the harmonic mean to the determination of dissociation constants of stereoisomeric mixtures of biologically active compounds | Full Text | References | PDF (360.9 KB)
  • 727 Views
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Original Article

Article
Isoflurane prevents learning deficiencies caused by brief hypoxia and hypotension in adult Sprague Dawley rats
Eduardo Chaparro, Carolina Quiroga, Diana Erasso, Gerardo Bosco, Alessandro Rubini, Devanand Mangar & Enrico Camporesi
Pages: 895-900
Published online: 11 Feb 2014
AbstractforIsoflurane prevents learning deficiencies caused by brief hypoxia and hypotension in adult Sprague Dawley rats | Full Text | References | PDF (348.8 KB)
  • 395 Views
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Research Article

Article
Carbonic anhydrase inhibition by 1-aroyl-3-(4-aminosulfonylphenyl)thioureas
Aamer Saeed, Mariya al-Rashida, Mehwish Hamayoun, Amara Mumtaz & Jamshed Iqbal
Pages: 901-905
Published online: 25 Mar 2014
AbstractforCarbonic anhydrase inhibition by 1-aroyl-3-(4-aminosulfonylphenyl)thioureas | Full Text | References | PDF (679.5 KB) | Supplemental
  • 1047 Views
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Article
Biochemical characterization of the δ-carbonic anhydrase from the marine diatom Thalassiosira weissflogii, TweCA
Sonia Del Prete, Daniela Vullo, Viviana De Luca, Claudiu T. Supuran & Clemente Capasso
Pages: 906-911
Published online: 24 Jan 2014
AbstractforBiochemical characterization of the δ-carbonic anhydrase from the marine diatom Thalassiosira weissflogii, TweCA | Full Text | References | PDF (413.7 KB)
  • 1541 Views
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