Cancer Biology & Therapy, Volume 16, Issue 1 (2015)

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Cancer Biology & Therapy, Volume 16, Issue 1 (2015)

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REVIEWS

Review Article
Crosstalk between Wnt/β-catenin and Hedgehog/Gli signaling pathways in colon cancer and implications for therapy
Li Song, Zhuo-Yu Li, Wei-Ping Liu & Mei-Rong Zhao
Pages: 1-7
Published online: 18 Feb 2015
AbstractforCrosstalk between Wnt/β-catenin and Hedgehog/Gli signaling pathways in colon cancer and implications for therapy | Full Text | References | PDF (365 KB)
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Article
Sleeping Beauty transposon system for genetic etiological research and gene therapy of cancers
Xiaomei Hou, Yan Du, Yang Deng, Jianfeng Wu & Guangwen Cao
Pages: 8-16
Published online: 18 Feb 2015
AbstractforSleeping Beauty transposon system for genetic etiological research and gene therapy of cancers | Full Text | References | PDF (217.3 KB)
  • 4525 Views
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JOURNAL CLUBS

Article
2-weekly docetaxel: issues for clinical practice
F Massari, F Maines, E Bria, E Galligioni, O Caffo & G Tortora
Pages: 17-18
Published online: 18 Feb 2015
Abstractfor2-weekly docetaxel: issues for clinical practice | Full Text | References | PDF (47.4 KB)
  • 634 Views
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Article
Structural studies reveal thalidomide's mechanism of action and clinical effects: crystal clear or clearly complexed?
Ariel M Ley, Cindy H Chau & William D Figg
Pages: 19-20
Published online: 18 Feb 2015
AbstractforStructural studies reveal thalidomide's mechanism of action and clinical effects: crystal clear or clearly complexed? | Full Text | References | PDF (45.8 KB)
  • 1629 Views
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MEETING REPORT

Article
RNA editing, epitranscriptomics, and processing in cancer progression
Keren L Witkin, Sean E Hanlon, Jennifer A Strasburger, John M Coffin, Samie R Jaffrey, T Kevin Howcroft, Peter C Dedon, Joan A Steitz, Phil J Daschner & Elizabeth Read-Connole
Pages: 21-27
Published online: 18 Feb 2015
AbstractforRNA editing, epitranscriptomics, and processing in cancer progression | Full Text | References | PDF (105.2 KB)
  • 3234 Views
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BEDSIDE TO BENCH REPORT

Article
Therapeutic approach guided by genetic alteration: Use of MTOR inhibitor in renal medullary carcinoma with loss of PTEN expression
Jacob S Lipkin, Syed M Rizvi, Zoran Gatalica, Nabeel E Sarwani, Sheldon L Holder, Mathew Kaag, Joseph J Drabick & Monika Joshi
Pages: 28-33
Published online: 18 Feb 2015
AbstractforTherapeutic approach guided by genetic alteration: Use of MTOR inhibitor in renal medullary carcinoma with loss of PTEN expression | Full Text | References | PDF (646.9 KB)
  • 1246 Views
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RESEARCH PAPERS

Article
The preclinical evaluation of the dual mTORC1/2 inhibitor INK-128 as a potential anti-colorectal cancer agent
Chen Li, Jian-Feng Cui, Min-Bin Chen, Chao-Ying Liu, Feng Liu, Qian-De Zhang, Jian Zou & Pei-Hua Lu
Pages: 34-42
Published online: 18 Feb 2015
AbstractforThe preclinical evaluation of the dual mTORC1/2 inhibitor INK-128 as a potential anti-colorectal cancer agent | Full Text | References | PDF (896.8 KB) | Supplemental
  • 2025 Views
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Article
Gemcitabine resistant pancreatic cancer cell lines acquire an invasive phenotype with collateral hypersensitivity to histone deacetylase inhibitors
Betty K Samulitis, Kelvin W Pond, Erika Pond, Anne E Cress, Hitendra Patel, Lee Wisner, Charmi Patel, Robert T Dorr & Terry H Landowski
Pages: 43-51
Published online: 18 Feb 2015
AbstractforGemcitabine resistant pancreatic cancer cell lines acquire an invasive phenotype with collateral hypersensitivity to histone deacetylase inhibitors | Full Text | References | PDF (381.4 KB) | Supplemental
  • 4375 Views
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Article
Inhibition of SGK1 enhances mAR-induced apoptosis in MCF-7 breast cancer cells
Guilai Liu, Sabina Honisch, Guoxing Liu, Sebastian Schmidt, Stavros Pantelakos, Saad Alkahtani, Mahmoud Toulany, Florian Lang & Christos Stournaras
Pages: 52-59
Published online: 18 Feb 2015
AbstractforInhibition of SGK1 enhances mAR-induced apoptosis in MCF-7 breast cancer cells | Full Text | References | PDF (663.4 KB)
  • 1302 Views
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Article
Curcumin induces cell death of the main molecular myeloma subtypes, particularly the poor prognosis subgroups
Patricia Gomez-Bougie, Maxime Halliez, Sophie Maïga, Catherine Godon, Charlotte Kervoëlen, Catherine Pellat-Deceunynck, Philippe Moreau & Martine Amiot
Pages: 60-65
Published online: 18 Feb 2015
AbstractforCurcumin induces cell death of the main molecular myeloma subtypes, particularly the poor prognosis subgroups | Full Text | References | PDF (267.8 KB)
  • 2937 Views
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Article
Liposome-coated lipoplex–based carrier for antisense oligonucleotides
Paulina Wyrozumska, Justyna Meissner, Monika Toporkiewicz, Marta Szarawarska, Kazimierz Kuliczkowski, Maciej Ugorski, Marta A Walasek & Aleksander F Sikorski
Pages: 66-76
Published online: 18 Feb 2015
AbstractforLiposome-coated lipoplex–based carrier for antisense oligonucleotides | Full Text | References | PDF (692.2 KB)
  • 2142 Views
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Article
AMPK/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis in human gastric cancer cell
Gang Han, Hangjun Gong, Yidong Wang, Shaowen Guo & Kun Liu
Pages: 77-87
Published online: 18 Feb 2015
AbstractforAMPK/mTOR-mediated inhibition of survivin partly contributes to metformin-induced apoptosis in human gastric cancer cell | Full Text | References | PDF (1.1 MB)
  • 2010 Views
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Article
ShRNA-mediated silencing of the ubiquitin-specific protease 22 gene restrained cell progression and affected the Akt pathway in nasopharyngeal carcinoma
Ya-Jing Zhuang, Zhi-Wei Liao, Hong-wei Yu, Xian-Lu Song, Yuan Liu, Xing-Yuan Shi, Xiao-dan Lin & Tong-Chong Zhou
Pages: 88-96
Published online: 18 Feb 2015
AbstractforShRNA-mediated silencing of the ubiquitin-specific protease 22 gene restrained cell progression and affected the Akt pathway in nasopharyngeal carcinoma | Full Text | References | PDF (724.6 KB)
  • 887 Views
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Article
Overexpression of SCLIP promotes growth and motility in glioblastoma cells
Yanmin Zhang, Shilei Ni, Bin Huang, Liyan Wang, Xianghong Zhang, Xian Li, Han Wang, Shuai Liu, Aijun Hao & Xingang Li
Pages: 97-105
Published online: 18 Feb 2015
AbstractforOverexpression of SCLIP promotes growth and motility in glioblastoma cells | Full Text | References | PDF (878.4 KB) | Supplemental
  • 1005 Views
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Article
Dasatinib reverses the multidrug resistance of breast cancer MCF-7 cells to doxorubicin by downregulating P-gp expression via inhibiting the activation of ERK signaling pathway
Ting Chen, Changyuan Wang, Qi Liu, Qiang Meng, Huijun Sun, Xiaokui Huo, Pengyuan Sun, Jinyong Peng, Zhihao Liu, Xiaobo Yang & Kexin Liu
Pages: 106-114
Published online: 18 Feb 2015
AbstractforDasatinib reverses the multidrug resistance of breast cancer MCF-7 cells to doxorubicin by downregulating P-gp expression via inhibiting the activation of ERK signaling pathway | Full Text | References | PDF (593.8 KB) | Supplemental
  • 2286 Views
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Article
Down regulation of miR-202 modulates Mxd1 and Sin3A repressor complexes to induce apoptosis of pancreatic cancer cells
Lulu Farhana, Marcia I Dawson & Joseph A Fontana
Pages: 115-124
Published online: 18 Feb 2015
AbstractforDown regulation of miR-202 modulates Mxd1 and Sin3A repressor complexes to induce apoptosis of pancreatic cancer cells | Full Text | References | PDF (623.4 KB)
  • 1294 Views
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Article
The glycosyltransferase LARGE2 is repressed by Snail and ZEB1 in prostate cancer
Qin Huang, Michael R Miller, James Schappet & Michael D Henry
Pages: 125-136
Published online: 18 Feb 2015
AbstractforThe glycosyltransferase LARGE2 is repressed by Snail and ZEB1 in prostate cancer | Full Text | References | PDF (922.1 KB) | Supplemental
  • 1123 Views
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Article
Enhancement of ionizing radiation response by histamine in vitro and in vivo in human breast cancer
Diego J Martinel Lamas, Jorge E Cortina, Clara Ventura, Helena A Sterle, Eduardo Valli, Karina B Balestrasse, Horacio Blanco, Graciela A Cremaschi, Elena S Rivera & Vanina A Medina
Pages: 137-148
Published online: 18 Feb 2015
AbstractforEnhancement of ionizing radiation response by histamine in vitro and in vivo in human breast cancer | Full Text | References | PDF (890.7 KB)
  • 1486 Views
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Article
Wnt pathway activation and ABCB1 expression account for attenuation of Proteasome inhibitor-mediated apoptosis in multidrug-resistant cancer cells
Kowit Yu Chong, Chih-Jung Hsu, Tsai-Hsien Hung, Han-Shu Hu, Tsung-Teng Huang, Tzu-Hao Wang, Chihuei Wang, Chuan-Mu Chen, Kong Bung Choo & Ching-Ping Tseng
Pages: 149-159
Published online: 18 Feb 2015
AbstractforWnt pathway activation and ABCB1 expression account for attenuation of Proteasome inhibitor-mediated apoptosis in multidrug-resistant cancer cells | Full Text | References | PDF (664.1 KB)
  • 1462 Views
  • 15 CrossRef citations
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Article
MiR-101 inhibits cell growth and tumorigenesis of Helicobacter pylori related gastric cancer by repression of SOCS2
Xiaoying Zhou, Yang Xia, Lin Li & Guoxin Zhang
Pages: 160-169
Published online: 18 Feb 2015
AbstractforMiR-101 inhibits cell growth and tumorigenesis of Helicobacter pylori related gastric cancer by repression of SOCS2 | Full Text | References | PDF (1.1 MB) | Supplemental
  • 1160 Views
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Article
Interplay between VEGF-A and cMET signaling in human vestibular schwannomas and schwann cells
Sonam Dilwali, Daniel Roberts & Konstantina M Stankovic
Pages: 170-175
Published online: 18 Feb 2015
AbstractforInterplay between VEGF-A and cMET signaling in human vestibular schwannomas and schwann cells | Full Text | References | PDF (337.8 KB)
  • 1508 Views
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Article
Cryptotanshinone inhibits breast cancer cell growth by suppressing estrogen receptor signaling
Shanhu Li, Hongtao Wang, Liu Hong, Wei Liu, Fang Huang, Jian Wang, Peng Wang, Xiaoqing Zhang & Jianguang Zhou
Pages: 176-184
Published online: 18 Feb 2015
AbstractforCryptotanshinone inhibits breast cancer cell growth by suppressing estrogen receptor signaling | Full Text | References | PDF (588.1 KB)
  • 1206 Views
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