1,317
Views
283
CrossRef citations to date
0
Altmetric
Research Article

IPCS Framework for Analyzing the Relevance of a Noncancer Mode of Action for Humans

, , , , , , , & show all
Pages 87-96 | Published online: 10 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (44)

Vinita Chauhan, Jihang Yu, Ngoc Vuong, Lynne T. Haber, Andrew Williams, Scott S. Auerbach, Danielle Beaton, Yi Wang, Robert Stainforth, Ruth C. Wilkins, Edouard I. Azzam, Richard B. Richardson, Md Gulam Musawwir Khan, Ashok Jadhav, Julie J. Burtt, Julie Leblanc, Kristi Randhawa, Knut Erik Tollefsen & Carole L. Yauk. (2023) Considerations for application of benchmark dose modeling in radiation research: workshop highlights. International Journal of Radiation Biology 99:9, pages 1320-1331.
Read now
Samuel M. Cohen, Christopher Bevan, Bhaskar Gollapudi & James E. Klaunig. (2023) Evaluation of the carcinogenicity of carbon tetrachloride. Journal of Toxicology and Environmental Health, Part B 26:6, pages 342-370.
Read now
T.G. Osimitz & W. Droege. (2022) Adverse Outcome Pathway for Antimicrobial Quaternary Ammonium Compounds. Journal of Toxicology and Environmental Health, Part A 85:12, pages 494-510.
Read now
Mark A. Pemberton & Ian Kimber. (2022) Methyl methacrylate and respiratory sensitisation: a comprehensive review. Critical Reviews in Toxicology 52:2, pages 139-166.
Read now
Tomoya Yamada, Brian G. Lake & Samuel M. Cohen. (2022) Evaluation of the human hazard of the liver and lung tumors in mice treated with permethrin based on mode of action. Critical Reviews in Toxicology 52:1, pages 1-31.
Read now
Chad M. Thompson, Robinan Gentry, Seneca Fitch, Kun Lu & Harvey J. Clewell. (2020) An updated mode of action and human relevance framework evaluation for Formaldehyde-Related nasal tumors. Critical Reviews in Toxicology 50:10, pages 919-952.
Read now
Robinan Gentry, Chad M. Thompson, Allison Franzen, Joshua Salley, Richard Albertini, Kun Lu & Tracy Greene. (2020) Using mechanistic information to support evidence integration and synthesis: a case study with inhaled formaldehyde and leukemia. Critical Reviews in Toxicology 50:10, pages 885-918.
Read now
Virunya S. Bhat, Samuel M. Cohen, Elliot B. Gordon, Charles E. Wood, John M. Cullen, Mark A. Harris, Deborah M. Proctor & Chad M. Thompson. (2020) An adverse outcome pathway for small intestinal tumors in mice involving chronic cytotoxicity and regenerative hyperplasia: a case study with hexavalent chromium, captan, and folpet. Critical Reviews in Toxicology 50:8, pages 685-706.
Read now
Robyn L. Prueitt, Wenchao Li, Yu-Chi Chang, Paolo Boffetta & Julie E. Goodman. (2020) Systematic review of the potential respiratory carcinogenicity of metallic nickel in humans. Critical Reviews in Toxicology 50:7, pages 605-639.
Read now
Joyce S. Tsuji, Ellen T. Chang, P. Robinan Gentry, Harvey J. Clewell, Paolo Boffetta & Samuel M. Cohen. (2019) Dose-response for assessing the cancer risk of inorganic arsenic in drinking water: the scientific basis for use of a threshold approach. Critical Reviews in Toxicology 49:1, pages 36-84.
Read now
Harvey J. Clewell, Janice W. Yager, Tracy B. Greene & P. Robinan Gentry. (2018) Application of the adverse outcome pathway (AOP) approach to inform mode of action (MOA): A case study with inorganic arsenic. Journal of Toxicology and Environmental Health, Part A 81:18, pages 893-912.
Read now
David Adenuga, Katy Goyak & R. Jeffrey Lewis. (2017) Evaluating the MoA/human relevance framework for F-344 rat liver epithelioid granulomas with mineral oil hydrocarbons. Critical Reviews in Toxicology 47:9, pages 754-770.
Read now
Alan Boobis, Paul Brown, Mark Timothy David Cronin, James Edwards, Corrado Lodovico Galli, Jay Goodman, Abigail Jacobs, David Kirkland, Mirjam Luijten, Cyril Marsaux, Matthew Martin, Chihae Yang & Heli Miriam Hollnagel. (2017) Origin of the TTC values for compounds that are genotoxic and/or carcinogenic and an approach for their re-evaluation. Critical Reviews in Toxicology 47:8, pages 710-732.
Read now
Ellen Mihaich, Marie Capdevielle, Daniella Urbach-Ross & Brian Slezak. (2017) Hypothesis-driven weight-of-evidence analysis of endocrine disruption potential: a case study with triclosan. Critical Reviews in Toxicology 47:4, pages 263-285.
Read now
Robyn L. Prueitt & Julie E. Goodman. (2016) Evaluation of neural reflex activation as a mode of action for the acute respiratory effects of ozone. Inhalation Toxicology 28:11, pages 484-499.
Read now
Mirjam Luijten, Evelyn D. Olthof, Betty C. Hakkert, Emiel Rorije, Jan-Willem van der Laan, Ruud A. Woutersen & Jan van Benthem. (2016) An integrative test strategy for cancer hazard identification. Critical Reviews in Toxicology 46:7, pages 615-639.
Read now
D. Gayle DeBord, Lyle Burgoon, Stephen W. Edwards, Lynne T. Haber, M. Helen Kanitz, Eileen Kuempel, Russell S. Thomas & Berran Yucesoy. (2015) Systems Biology and Biomarkers of Early Effects for Occupational Exposure Limit Setting. Journal of Occupational and Environmental Hygiene 12:sup1, pages S41-S54.
Read now
Heinz-Peter Gelbke, Marcy Banton, Edgar Leibold, Mark Pemberton & Susan Leanne Samson. (2015) A critical review finds styrene lacks direct endocrine disruptor activity. Critical Reviews in Toxicology 45:9, pages 727-764.
Read now
Ted W. Simon, S. Stoney Simons$suffix/text()$suffix/text(), R. Julian Preston, Alan R. Boobis, Samuel M. Cohen, Nancy G. Doerrer, Penelope A. Fenner-Crisp, Tami S. McMullin, Charlene A. McQueen & J. Craig Rowlands. (2014) The use of mode of action information in risk assessment: Quantitative key events/dose-response framework for modeling the dose-response for key events. Critical Reviews in Toxicology 44:sup3, pages 17-43.
Read now
Ursula Gundert-Remy, Ulrike Bernauer, Brunhilde Blömeke, Barbara Döring, Eric Fabian, Carsten Goebel, Stefanie Hessel, Christine Jäckh, Alfonso Lampen, Franz Oesch, Ernst Petzinger, Wolfgang Völkel & Peter H. Roos. (2014) Extrahepatic metabolism at the body's internal–external interfaces. Drug Metabolism Reviews 46:3, pages 291-324.
Read now
Claire Terry, Reza J. Rasoulpour, Shakil Saghir, Sue Marty, B. Bhaskar Gollapudi & Richard Billington. (2014) Application of a novel integrated toxicity testing strategy incorporating “3R” principles of animal research to evaluate the safety of a new agrochemical sulfoxaflor. Critical Reviews in Toxicology 44:sup2, pages 1-14.
Read now
Robert G. Ellis-Hutchings, Reza J. Rasoulpour, Claire Terry, Edward W. Carney & Richard Billington. (2014) Human relevance framework evaluation of a novel rat developmental toxicity mode of action induced by sulfoxaflor. Critical Reviews in Toxicology 44:sup2, pages 45-62.
Read now
Matthew J. LeBaron, B. Bhaskar Gollapudi, Claire Terry, Richard Billington & Reza J. Rasoulpour. (2014) Human relevance framework for rodent liver tumors induced by the insecticide sulfoxaflor. Critical Reviews in Toxicology 44:sup2, pages 15-24.
Read now
Reza J. Rasoulpour, Claire Terry, Matthew J. LeBaron, Kenneth Stebbins, Robert G. Ellis-Hutchings & Richard Billington. (2014) Mode-of-action and human relevance framework analysis for rat Leydig cell tumors associated with sulfoxaflor. Critical Reviews in Toxicology 44:sup2, pages 25-44.
Read now
Mitscheli Sanches Da Rocha, Lora L. Arnold, Maria Luiza Cotrim Sartor De Oliveira, Shadia M. Ihlaseh Catalano, Ana Paula Ferragut Cardoso, Merielen G. N. Pontes, Bianca Ferrucio, Puttappa R. Dodmane, Samuel M. Cohen & João Lauro V. De Camargo. (2014) Diuron-induced rat urinary bladder carcinogenesis: Mode of action and human relevance evaluations using the International Programme on Chemical Safety framework. Critical Reviews in Toxicology 44:5, pages 393-406.
Read now
Melvin E. Andersen, R. Julian Preston, Andrew Maier, Alison M. Willis & Jacqueline Patterson. (2014) Dose–response approaches for nuclear receptor-mediated modes of action for liver carcinogenicity: Results of a workshop. Critical Reviews in Toxicology 44:1, pages 50-63.
Read now
J. Christopher Corton, Michael L. Cunningham, B. Timothy Hummer, Christopher Lau, Bette Meek, Jeffrey M. Peters, James A. Popp, Lorenz Rhomberg, Jennifer Seed & James E. Klaunig. (2014) Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study. Critical Reviews in Toxicology 44:1, pages 1-49.
Read now
Drew R. Ekman, Gerald T. Ankley, Vicki S. Blazer, Timothy W. Collette, Natàlia Garcia-Reyero, Luke R. Iwanowicz, Zachary G. Jorgenson, Kathy E. Lee, Pat M. Mazik, David H. Miller, Edward J. Perkins, Edwin T. Smith, Joseph E. Tietge & Daniel L. Villeneuve. (2013) Environmental Reviews and Case Studies: Biological Effects–Based Tools for Monitoring Impacted Surface Waters in the Great Lakes: A Multiagency Program in Support of the Great Lakes Restoration Initiative. Environmental Practice 15:4, pages 409-426.
Read now
Lorenz R. Rhomberg, Julie E. Goodman, Lisa A. Bailey, Robyn L. Prueitt, Nancy B. Beck, Christopher Bevan, Michael Honeycutt, Norbert E. Kaminski, Greg Paoli, Lynn H. Pottenger, Roberta W. Scherer, Kimberly C. Wise & Richard A. Becker. (2013) A survey of frameworks for best practices in weight-of-evidence analyses. Critical Reviews in Toxicology 43:9, pages 753-784.
Read now
Samuel M. Cohen, Lora L. Arnold, Barbara D. Beck, Ari S. Lewis & Michal Eldan. (2013) Evaluation of the carcinogenicity of inorganic arsenic. Critical Reviews in Toxicology 43:9, pages 711-752.
Read now
Chad M. Thompson, Deborah M. Proctor, Mina Suh, Laurie C. Haws, Christopher R. Kirman & Mark A. Harris. (2013) Assessment of the mode of action underlying development of rodent small intestinal tumors following oral exposure to hexavalent chromium and relevance to humans. Critical Reviews in Toxicology 43:3, pages 244-274.
Read now
DouglasL. Weed. (2013) The Quality of Nutrition and Cancer Reviews: A Systematic Assessment. Critical Reviews in Food Science and Nutrition 53:3, pages 276-286.
Read now
Lorenz R. Rhomberg, Julie E. Goodman, Warren G. Foster, Christopher J. Borgert & Glen Van Der Kraak. (2012) A critique of the European Commission Document, “State of the Art Assessment of Endocrine Disrupters”. Critical Reviews in Toxicology 42:6, pages 465-473.
Read now
Robyn L. Prueitt, Julie E. Goodman, Lisa A. Bailey & Lorenz R. Rhomberg. (2011) Hypothesis-based weight-of-evidence evaluation of the neurodevelopmental effects of chlorpyrifos. Critical Reviews in Toxicology 41:10, pages 822-903.
Read now
P. Robinan Gentry, Harvey J. Clewell$suffix/text()$suffix/text(), Rebecca Clewell, Jerry Campbell, Cynthia Van Landingham & Annette M. Shipp. (2011) Challenges in the application of quantitative approaches in risk assessment: a case study with di-(2-ethylhexyl)phthalate. Critical Reviews in Toxicology 41:sup2, pages 1-72.
Read now
Neil Carmichael, Melanie Bausen, Alan R. Boobis, Samuel M. Cohen, Michelle Embry, Claudia Fruijtier-Pölloth, Helmut Greim, Richard Lewis, M.E. (Bette) Meek, Howard Mellor, Carolyn Vickers & John Doe. (2011) Using mode of action information to improve regulatory decision-making: An ECETOC/ILSI RF/HESI workshop overview. Critical Reviews in Toxicology 41:3, pages 175-186.
Read now
Samuel M. Cohen, Elliot B. Gordon, Pramila Singh, Gail T. Arce & Abraham Nyska. (2010) Carcinogenic mode of action of folpet in mice and evaluation of its relevance to humans. Critical Reviews in Toxicology 40:6, pages 531-545.
Read now
Vicki Dellarco, Tala Henry, Phil Sayre, Jennifer Seed & Steven Bradbury. (2010) Meeting The Common Needs of a More Effective and Efficient Testing and Assessment Paradigm for Chemical Risk Management. Journal of Toxicology and Environmental Health, Part B 13:2-4, pages 347-360.
Read now
M.E. (Bette) Meek, Leonard S. Levy, Barbara D. Beck, Ruth Danzeisen, Joyce M. Donohue, Ian M. F. Arnold & Daniel Krewski. (2010) Risk Assessment Practice for Essential Metals. Journal of Toxicology and Environmental Health, Part A 73:2-3, pages 253-260.
Read now
Susan Goldhaber, David Dorman, Donald Gardner & Femi Adeshina. (2009) Provisional Advisory Levels (PALs) for acrylonitrile. Inhalation Toxicology 21:sup3, pages 17-55.
Read now
Elizabeth Julien , AlanR. Boobis, StephenS. Olin & The ILSI Research Foundation Threshold Working Group. (2009) The Key Events Dose-Response Framework: A Cross-Disciplinary Mode-of-Action Based Approach to Examining Dose-Response and Thresholds. Critical Reviews in Food Science and Nutrition 49:8, pages 682-689.
Read now
AlanR. Boobis, GeorgeP. Daston, R. Julian Preston & StephenS. Olin. (2009) Application of Key Events Analysis to Chemical Carcinogens and Noncarcinogens. Critical Reviews in Food Science and Nutrition 49:8, pages 690-707.
Read now
M. E. (Bette) Meek, Sir Colin Berry, AlanR. Boobis, SamuelM. Cohen, Margaret Hartley, Sharon Munn, Stephen Olin, Josef Schlatter & Carolyn Vickers. (2008) Re: Guyton, Kathryn Z., Barone, Stanley, Jr., Brown, Rebecca C., Euling, Susan Y., Jinot, Jennifer, Makris, Susan (2008). Mode of Action Frameworks: A Critical Analysis. Journal of Toxicology and Environmental Health, Part B, 11(1): 16–31. Journal of Toxicology and Environmental Health, Part B 11:8, pages 681-685.
Read now

Articles from other publishers (239)

Daniel A. Vallero & Trevor M. Letcher. 2024. Unraveling Environmental Disasters. Unraveling Environmental Disasters 511 548 .
Donna S. Macmillan & Catherine Willett. 2024. Encyclopedia of Toxicology. Encyclopedia of Toxicology 171 181 .
Christian Strupp, Marco Corvaro, Samuel M. Cohen, J. Christopher Corton, Kumiko Ogawa, Lysiane Richert & Miriam N. Jacobs. (2023) Increased Cell Proliferation as a Key Event in Chemical Carcinogenesis: Application in an Integrated Approach for the Testing and Assessment of Non-Genotoxic Carcinogenesis. International Journal of Molecular Sciences 24:17, pages 13246.
Crossref
Robyn L. Prueitt, Mary L. Hixon, Tongyao Fan, Nicole S. Olgun, Perry Piatos, Jean Zhou & Julie E. Goodman. (2023) Systematic review of the potential carcinogenicity of bisphenol A in humans. Regulatory Toxicology and Pharmacology 142, pages 105414.
Crossref
Yangchun Zhang, Ziqi Liu, Ziwei Wang, Huan Gao, Yuqing Wang, Mengxing Cui, Honghao Peng, Yongmei Xiao, Yuan Jin, Dianke Yu, Wen Chen & Qing Wang. (2023) Health risk assessment of cadmium exposure by integration of an in silico physiologically based toxicokinetic model and in vitro tests. Journal of Hazardous Materials 443, pages 130191.
Crossref
John L. Vahle, Virunya Bhat & Charles E. Wood. 2023. Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 2 : Safety Assessment Environmental Toxicologic Pathology. Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 2 : Safety Assessment Environmental Toxicologic Pathology 629 656 .
Angelo Moretto. 2023. Present Knowledge in Food Safety. Present Knowledge in Food Safety 720 735 .
Tanmayee Basu, Rashi Chugh, Ranjit Singh Gujjar & Atul Kumar Upadhyay. 2023. Skin 3-D Models and Cosmetics Toxicity. Skin 3-D Models and Cosmetics Toxicity 187 210 .
Suradeep Basak, Joseph Lewis, Sudershan Rao Vemula & Prathapkumar Shetty Halady. 2023. Biomedical Applications and Toxicity of Nanomaterials. Biomedical Applications and Toxicity of Nanomaterials 203 227 .
A. N. Koterov & L. N. Ushenkova. (2023) Causal Criteria in Medical and Biological Disciplines: History, Essence, and Radiation Aspects. Report 4, Part 1: The Post-Hill Criteria and Ecolgoical Criteria. Biology Bulletin 49:12, pages 2423-2466.
Crossref
A. N. Koterov. (2023) Causal Criteria in Medical and Biological Disciplines: History, Essence, and Radiation Aspect. Report 3, Part 2: Hill’s Last Four Criteria: Use and Limitations. Biology Bulletin 49:11, pages 2184-2222.
Crossref
Satoki Fukunaga, Keiko Ogata, Ayumi Eguchi, Kohei Matsunaga, Kengo Sakurai, Jun Abe, Samuel M. Cohen & Hiroyuki Asano. (2022) Evaluation of the mode of action and human relevance of liver tumors in male mice treated with epyrifenacil. Regulatory Toxicology and Pharmacology 136, pages 105268.
Crossref
C.R. Kirman, C.M. North, N.Y. Tretyakova, N. Erraguntla, H. Shen & S.M. Hays. (2022) Use of biomarker data and metabolite relative potencies to support derivation of noncancer reference values based on the reproductive and developmental toxicity effects of 1,3-butadiene. Regulatory Toxicology and Pharmacology 134, pages 105239.
Crossref
Engi Abdelhady Algharably, Emma Di Consiglio, Emanuela Testai, Francesca Pistollato, Hans Mielke & Ursula Gundert-Remy. (2022) In Vitro–In Vivo Extrapolation by Physiologically Based Kinetic Modeling: Experience With Three Case Studies and Lessons Learned. Frontiers in Toxicology 4.
Crossref
Katsumasa Iwashita, Yoshinori Hosokawa, Ryo Ihara, Taiki Miyamoto, Mitsuhiro Otani, Jun Abe, Koji Asano, Odile Mercier, Kaori Miyata & Susan Barlow. (2022) Flumioxazin, a PPO inhibitor: A weight-of-evidence consideration of its mode of action as a developmental toxicant in the rat and its relevance to humans. Toxicology 472, pages 153160.
Crossref
Melvin E. Andersen. (2022) Assessing modes of action, measures of tissue dose and human relevance of rodent toxicity endpoints with octamethylcyclotetrasiloxane (D4). Toxicology Letters 357, pages 57-72.
Crossref
Kota Hirasawa, Jun Abe, Hirohisa Nagahori & Sachiko Kitamoto. (2022) Prediction of the human pharmacokinetics of epyrifenacil and its major metabolite, S-3100-CA, by a physiologically based pharmacokinetic modeling using chimeric mice with humanized liver. Toxicology and Applied Pharmacology 439, pages 115912.
Crossref
Hiroshi Satoh, Satoshi Machino, Tatsuya Fujii, Midori Yoshida, Satoshi Asano, Yoko Yokoyama & Katsuhiro Miyajima. (2022) Important Points at Interpretation ofNongenotoxic-Carcinogenicity Induced by Pesticidesin Rodent Bioassaysげっ歯類を用いた農薬の発がん性試験結果を解釈する上で留意すべき点について. Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) 63:1, pages 34-42.
Crossref
Fareeha Anwar, Uzma Saleem, Atta ur rehman, Bashir Ahmad, Tariq Ismail, Muhammad Usman Mirza & Sarfraz Ahmad. (2022) Acute Oral, Subacute, and Developmental Toxicity Profiling of Naphthalene 2-Yl, 2-Chloro, 5-Nitrobenzoate: Assessment Based on Stress Response, Toxicity, and Adverse Outcome Pathways. Frontiers in Pharmacology 12.
Crossref
Shihori Tanabe, Magdalini Sachana & Rex FitzGerald. 2022. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 63 72 .
Gunnar F. Nordberg, Max Costa & Bruce A. Fowler. 2022. Handbook on the Toxicology of Metals. Handbook on the Toxicology of Metals 629 661 .
A. N. Koterov, L. N. Ushenkova & A. P. Biryukov. (2022) Hill’s Criterion ‘Experiment’: The Counterfactual Approach in Non-Radiation and Radiation Sciences. Biology Bulletin 48:12, pages 2149-2173.
Crossref
Terje Svingen, Daniel L Villeneuve, Dries Knapen, Eleftheria Maria Panagiotou, Monica Kam Draskau, Pauliina Damdimopoulou & Jason M O’Brien. (2021) A Pragmatic Approach to Adverse Outcome Pathway Development and Evaluation. Toxicological Sciences 184:2, pages 183-190.
Crossref
Keiko Ogata, Yang Liu, Ayako Ohara, Kensuke Kawamoto, Miwa Kondo, Kumiko Kobayashi, Takako Fukuda, Hiroyuki Asano, Sachiko Kitamoto, Brian G Lake, Samuel M Cohen & Tomoya Yamada. (2021) Club Cells Are the Primary Target for Permethrin-Induced Mouse Lung Tumor Formation. Toxicological Sciences 184:1, pages 15-32.
Crossref
Maria Herlin, Ismael Sánchez-Pérez, Javier Esteban, Merja Korkalainen, Xavier Barber, Mikko A.J. Finnilä, Gerd Hamscher, Bertrand Joseph, Matti Viluksela & Helen Håkansson. (2021) Bone toxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the retinoid system: A causality analysis anchored in osteoblast gene expression and mouse data. Reproductive Toxicology 105, pages 25-43.
Crossref
Simon More, Vasileios Bampidis, Diane Benford, Claude Bragard, Thorhallur Halldorsson, Antonio Hernández‐Jerez, Susanne Hougaard Bennekou, Kostas Koutsoumanis, Claude Lambré, Kyriaki Machera, Hanspeter Naegeli, Søren Nielsen, Josef Schlatter, Dieter Schrenk, Vittorio Silano (deceased)Dominique Turck, Maged Younes, Jacqueline Castenmiller, Qasim Chaudhry, Francesco Cubadda, Roland Franz, David Gott, Jan Mast, Alicja Mortensen, Agnes G. Oomen, Stefan Weigel, Eric Barthelemy, Ana Rincon, José Tarazona & Reinhilde Schoonjans. (2021) Guidance on risk assessment of nanomaterials to be applied in the food and feed chain: human and animal health. EFSA Journal 19:8.
Crossref
Carr J. Smith, Thomas A. Perfetti, A. Wallace Hayes, Sir Colin Berry, James E. Trosko, Judy A. King, Jay I. Goodman, C. Glenn Begley & Anthony Dayan. (2021) Categorizing the characteristics of human carcinogens: a need for specificity. Archives of Toxicology 95:8, pages 2883-2889.
Crossref
Yangchun Zhang, Ziqi Liu, Qianmei He, Fei Wu, Yongmei Xiao, Wen Chen, Yuan Jin, Dianke Yu & Qing Wang. (2021) Construction of Mode of Action for Cadmium-Induced Renal Tubular Dysfunction Based on a Toxicity Pathway-Oriented Approach. Frontiers in Genetics 12.
Crossref
Andrea Hochegger, Sabrina Moret, Lucie Geurts, Thomas Gude, Erich Leitner, Birgit Mertens, Susan O'Hagan, Fátima Poças, Thomas J. Simat & Giorgia Purcaro. (2021) Mineral oil risk assessment: Knowledge gaps and roadmap. Outcome of a multi-stakeholders workshop. Trends in Food Science & Technology 113, pages 151-166.
Crossref
Werner Bomann, Helen Tinwell, Peter Jenkinson & Felix M. Kluxen. (2021) Metribuzin-induced non-adverse liver changes result in rodent-specific non-adverse thyroid effects via uridine 5′-diphospho-glucuronosyltransferase (UDPGT, UGT) modulation. Regulatory Toxicology and Pharmacology 122, pages 104884.
Crossref
Elena Menegola, Christina H.J. Veltman, Maria Battistoni, Francesca Di Renzo, Angelo Moretto, Francesca Metruccio, Anna Beronius, Johanna Zilliacus, Katerina Kyriakopoulou, Anastasia Spyropoulou, Kyriaki Machera, Leo T.M. van der Ven & Mirjam Luijten. (2021) An adverse outcome pathway on the disruption of retinoic acid metabolism leading to developmental craniofacial defects. Toxicology 458, pages 152843.
Crossref
Tomoya Yamada. (2021) Application of humanized mice to toxicology studies: Evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR). Journal of Toxicologic Pathology 34:4, pages 283-297.
Crossref
Marina Goumenou, Aleksandra Buha Djordjevic, Loukia Vassilopoulou & Aristidis M. Tsatsakis. 2021. Toxicological Risk Assessment and Multi-System Health Impacts from Exposure. Toxicological Risk Assessment and Multi-System Health Impacts from Exposure 147 162 .
Daniel A. Vallero. 2021. Environmental Systems Science. Environmental Systems Science 293 357 .
Benjamin Kopp, Pascal Sanders, Imourana Alassane-Kpembi, Valérie Fessard, Daniel Zalko, Ludovic Le Hégarat & Marc Audebert. (2020) Synergic toxic effects of food contaminant mixtures in human cells. Mutagenesis 35:5, pages 415-424.
Crossref
Christian Strupp, Nicolas Quesnot, Lysiane Richert, Joanna Moore, Werner H. Bomann & Pramila Singh. (2020) Weight of evidence and human relevance evaluation of the benfluralin mode of action in rodents (Part I): Liver carcinogenesis. Regulatory Toxicology and Pharmacology 117, pages 104758.
Crossref
Christian Strupp, Nicolas Quesnot, Céline Weber-Parmentier, Lysiane Richert, Werner H. Bomann & Pramila Singh. (2020) Weight of Evidence and Human Relevance Evaluation of the Benfluralin Mode of Action in Rats (Part II): Thyroid carcinogenesis. Regulatory Toxicology and Pharmacology 117, pages 104736.
Crossref
Julie E. Goodman, Robyn L. Prueitt, Raymond D. Harbison & Giffe T. Johnson. (2020) Systematically evaluating and integrating evidence in National Ambient Air Quality Standards reviews. Global Epidemiology 2, pages 100019.
Crossref
Denise Bloch, Philip Marx‐Stoelting & Sabine Martin. (2020) Towards a tiered test strategy for plant protection products to address mixture toxicity by alternative approaches in human health assessment. Pest Management Science 76:10, pages 3326-3332.
Crossref
Xabier Arzuaga, Teneille Walker, Erin E. Yost, Elizabeth G. Radke & Andrew K. Hotchkiss. (2020) Use of the Adverse Outcome Pathway (AOP) framework to evaluate species concordance and human relevance of Dibutyl phthalate (DBP)-induced male reproductive toxicity. Reproductive Toxicology 96, pages 445-458.
Crossref
I. Ivanov & I. Ushakov. (2020) Basic Approaches to the Extrapolation of Data of Animals to Human in Radiobiological Experiment. Medical Radiology and radiation safety 65:3, pages 5-12.
Crossref
Julie E. Goodman, David B. Mayfield, Richard A. Becker, Suzanne B. Hartigan & Neeraja K. Erraguntla. (2020) Recommendations for further revisions to improve the International Agency for Research on Cancer (IARC) Monograph program. Regulatory Toxicology and Pharmacology 113, pages 104639.
Crossref
Shen Chen, Daochuan Li, Xiaonen Wu, Liping Chen, Bin Zhang, Yafei Tan, Dianke Yu, Yong Niu, Huawei Duan, Qiong Li, Rui Chen, Michael Aschner, Yuxin Zheng & Wen Chen. (2020) Application of cell-based biological bioassays for health risk assessment of PM2.5 exposure in three megacities, China. Environment International 139, pages 105703.
Crossref
Stanley T. Parish, Michael Aschner, Warren Casey, Marco Corvaro, Michelle R. Embry, Suzanne Fitzpatrick, Darren Kidd, Nicole C. Kleinstreuer, Beatriz Silva Lima, Raja S. Settivari, Douglas C. Wolf, Daiju Yamazaki & Alan Boobis. (2020) An evaluation framework for new approach methodologies (NAMs) for human health safety assessment. Regulatory Toxicology and Pharmacology 112, pages 104592.
Crossref
R. Bevan, P.T.C. Harrison, B. Jeffery & D. Mitchell. (2020) Evaluating the risk to humans from mineral oils in foods: Current state of the evidence. Food and Chemical Toxicology 136, pages 110966.
Crossref
Robinan Gentry, Allison Franzen & Tracy Greene. 2020. An Introduction to Interdisciplinary Toxicology. An Introduction to Interdisciplinary Toxicology 545 558 .
D. Krewski, M. E. Andersen, M. G. Tyshenko, K. Krishnan, T. Hartung, K. Boekelheide, J. F. Wambaugh, D. Jones, M. Whelan, R. Thomas, C. Yauk, T. Barton-Maclaren & I. Cote. (2019) Toxicity testing in the 21st century: progress in the past decade and future perspectives. Archives of Toxicology 94:1, pages 1-58.
Crossref
Joanna Klapacz & B. Bhaskar Gollapudi. (2019) Considerations for the Use of Mutation as a Regulatory Endpoint in Risk Assessment. Environmental and Molecular Mutagenesis 61:1, pages 84-93.
Crossref
Leslie A. Obert & Kendall S. Frazier. (2019) Intrarenal Renin–Angiotensin System Involvement in the Pathogenesis of Chronic Progressive Nephropathy—Bridging the Informational Gap Between Disciplines. Toxicologic Pathology 47:7, pages 799-816.
Crossref
K. Nadira De Abrew, Yuqing K. Shan, Xiaohong Wang, Jesse M. Krailler, Raghunandan M. Kainkaryam, Cathy C. Lester, Raja S. Settivari, Matthew J. LeBaron, Jorge M. Naciff & George P. Daston. (2019) Use of connectivity mapping to support read across: A deeper dive using data from 186 chemicals, 19 cell lines and 2 case studies. Toxicology 423, pages 84-94.
Crossref
Miwa Kondo, Kaori Miyata, Hirohisa Nagahori, Kayo Sumida, Thomas G Osimitz, Samuel M Cohen, Brian G Lake & Tomoya Yamada. (2019) Involvement of Peroxisome Proliferator-Activated Receptor-Alpha in Liver Tumor Production by Permethrin in the Female Mouse. Toxicological Sciences 168:2, pages 572-596.
Crossref
Samuel M. Cohen, Alan R. Boobis, Vicki L. Dellarco, John E. Doe, Penelope A. Fenner-Crisp, Angelo Moretto, Timothy P. Pastoor, Rita S. Schoeny, Jennifer G. Seed & Douglas C. Wolf. (2019) Chemical carcinogenicity revisited 3: Risk assessment of carcinogenic potential based on the current state of knowledge of carcinogenesis in humans. Regulatory Toxicology and Pharmacology 103, pages 100-105.
Crossref
Daniel A. Vallero. 2019. Waste. Waste 673 692 .
Magdalini Sachana. 2019. Biomarkers in Toxicology. Biomarkers in Toxicology 163 170 .
Gunnar F. Nordberg & Bruce A. Fowler. 2019. Risk Assessment for Human Metal Exposures. Risk Assessment for Human Metal Exposures 99 131 .
Gunnar F. Nordberg & Bruce A. Fowler. 2019. Risk Assessment for Human Metal Exposures. Risk Assessment for Human Metal Exposures 75 98 .
Thomas Hartung. (2018) Perspectives on In Vitro to In Vivo Extrapolations . Applied In Vitro Toxicology 4:4, pages 305-316.
Crossref
M. Sue Marty, Chris Borgert, Katie Coady, Richard Green, Steven L. Levine, Ellen Mihaich, Lisa Ortego, James R. Wheeler, Kun Don Yi & Leah M. Zorrilla. (2018) Distinguishing between endocrine disruption and non-specific effects on endocrine systems. Regulatory Toxicology and Pharmacology 99, pages 142-158.
Crossref
Cheryl A Murphy, Roger M Nisbet, Philipp Antczak, Natàlia Garcia-Reyero, Andre Gergs, Konstadia Lika, Teresa Mathews, Erik B Muller, Diane Nacci, Angela Peace, Christopher H Remien, Irvin R Schultz, Louise M Stevenson & Karen H Watanabe. (2018) Incorporating Suborganismal Processes into Dynamic Energy Budget Models for Ecological Risk Assessment. Integrated Environmental Assessment and Management 14:5, pages 615-624.
Crossref
Anthony Hardy, Diane Benford, Thorhallur Halldorsson, Michael John Jeger, Helle Katrine Knutsen, Simon More, Hanspeter Naegeli, Hubert Noteborn, Colin Ockleford, Antonia Ricci, Guido Rychen, Josef R. Schlatter, Vittorio Silano, Roland Solecki, Dominique Turck, Maged Younes, Qasim Chaudhry, Francesco Cubadda, David Gott, Agnes Oomen, Stefan Weigel, Melpo Karamitrou, Reinhilde Schoonjans & Alicja Mortensen. (2018) Guidance on risk assessment of the application of nanoscience and nanotechnologies in the food and feed chain: Part 1, human and animal health. EFSA Journal 16:7.
Crossref
Pierre Martin, Claire Bladier, Bette Meek, Olivier Bruyere, Eve Feinblatt, Mathilde Touvier, Laurence Watier & David Makowski. (2018) Weight of Evidence for Hazard Identification: A Critical Review of the Literature. Environmental Health Perspectives 126:7.
Crossref
Tomoya Yamada. (2018) Case examples of an evaluation of the human relevance of the pyrethroids/pyrethrins-induced liver tumours in rodents based on the mode of action. Toxicology Research 7:4, pages 681-696.
Crossref
Chad M. Thompson, Mina Suh, Deborah M. Proctor, Grace Chappell, Susan Borghoff, Robert Ellis-Hutchings, Karin Wiench & Lavorgie Finch. (2018) Assessment of the mode of action underlying development of forestomach tumors in rodents following oral exposure to ethyl acrylate and relevance to humans. Regulatory Toxicology and Pharmacology 96, pages 178-189.
Crossref
Niklas Andersson, Maria Arena, Domenica Auteri, Stefania Barmaz, Elise Grignard, Aude Kienzler, Peter Lepper, Alfonso Maria Lostia, Sharon Munn, Juan Manuel Parra Morte, Francesca Pellizzato, Jose Tarazona, Andrea Terron & Sander Van der Linden. (2018) Guidance for the identification of endocrine disruptors in the context of Regulations (EU) No 528/2012 and (EC) No 1107/2009. EFSA Journal 16:6.
Crossref
Yu-Mei Tan, Jeremy A. Leonard, Stephen Edwards, Justin Teeguarden, Alicia Paini & Peter Egeghy. (2018) Aggregate exposure pathways in support of risk assessment. Current Opinion in Toxicology 9, pages 8-13.
Crossref
Maureen E. Pittman, Stephen W. Edwards, Cataia Ives & Holly M. Mortensen. (2018) AOP-DB: A database resource for the exploration of Adverse Outcome Pathways through integrated association networks. Toxicology and Applied Pharmacology 343, pages 71-83.
Crossref
Susan P. Felter, Jennifer E. Foreman, Alan Boobis, J. Christopher Corton, Adriana M. Doi, Lynn Flowers, Jay Goodman, Lynne T. Haber, Abigail Jacobs, James E. Klaunig, Angela M. Lynch, Jonathan Moggs & Arun Pandiri. (2018) Human relevance of rodent liver tumors: Key insights from a Toxicology Forum workshop on nongenotoxic modes of action. Regulatory Toxicology and Pharmacology 92, pages 1-7.
Crossref
Samuel M. Cohen. (2018) Screening for human urinary bladder carcinogens: two-year bioassay is unnecessary. Toxicology Research 7:4, pages 565-575.
Crossref
Daniel Vallero. 2018. Translating Diverse Environmental Data into Reliable Information. Translating Diverse Environmental Data into Reliable Information 95 123 .
S.M. Cohen. 2018. Comprehensive Toxicology. Comprehensive Toxicology 226 247 .
S.A. Saghir & M.A. Dorato. 2018. Comprehensive Toxicology. Comprehensive Toxicology 95 118 .
J. Christopher Corton, Jeffrey M. Peters & James E. Klaunig. (2017) The PPARα-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions. Archives of Toxicology 92:1, pages 83-119.
Crossref
Catherine Willett, Suzanne Fitzpatrick, Bette Meek & Carl Westmoreland. 2018. A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment. A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment 349 378 .
Ursula G. Sauer, Lize Deferme, Laura Gribaldo, Jörg Hackermüller, Tewes Tralau, Ben van Ravenzwaay, Carole Yauk, Alan Poole, Weida Tong & Timothy W. Gant. (2017) The challenge of the application of 'omics technologies in chemicals risk assessment: Background and outlook. Regulatory Toxicology and Pharmacology 91, pages S14-S26.
Crossref
Elisabet Berggren, Andrew White, Gladys Ouedraogo, Alicia Paini, Andrea-Nicole Richarz, Frederic Y. Bois, Thomas Exner, Sofia Leite, Leo A. van Grunsven, Andrew Worth & Catherine Mahony. (2017) Ab initio chemical safety assessment: A workflow based on exposure considerations and non-animal methods. Computational Toxicology 4, pages 31-44.
Crossref
Mathieu Vinken, Dries Knapen, Lucia Vergauwen, Jan G. Hengstler, Michelle Angrish & Maurice Whelan. (2017) Adverse outcome pathways: a concise introduction for toxicologists. Archives of Toxicology 91:11, pages 3697-3707.
Crossref
A. Kienzler, M. G. Barron, S. E. Belanger, A. Beasley & M. R. Embry. (2017) Mode of Action (MOA) Assignment Classifications for Ecotoxicology: An Evaluation of Approaches. Environmental Science & Technology 51:17, pages 10203-10211.
Crossref
Mathieu Vinken. (2017) Editorial. Applied In Vitro Toxicology 3:3, pages 211-212.
Crossref
Anthony Hardy, Diane Benford, Thorhallur Halldorsson, Michael John Jeger, Helle Katrine Knutsen, Simon More, Hanspeter Naegeli, Hubert Noteborn, Colin Ockleford, Antonia Ricci, Guido Rychen, Josef R Schlatter, Vittorio Silano, Roland Solecki, Dominique Turck, Maged Younes, Jean‐Louis Bresson, John Griffin, Susanne Hougaard Benekou, Henk van Loveren, Robert Luttik, Antoine Messean, André Penninks, Giuseppe Ru, Jan Arend Stegeman, Wopke van der Werf, Johannes Westendorf, Rudolf Antonius Woutersen, Fulvio Barizzone, Bernard Bottex, Anna Lanzoni, Nikolaos Georgiadis & Jan Alexander. (2017) Guidance on the assessment of the biological relevance of data in scientific assessments. EFSA Journal 15:8.
Crossref
Yu Okuda, Masahiko Kushida, Kayo Sumida, Hirohisa Nagahori, Yoshimasa Nakamura, Hashihiro Higuchi, Satoshi Kawamura, Brian G. Lake, Samuel M. Cohen & Tomoya Yamada. (2017) Editor’s Highlight: Mode of Action Analysis for Rat Hepatocellular Tumors Produced by the Synthetic Pyrethroid Momfluorothrin: Evidence for Activation of the Constitutive Androstane Receptor and Mitogenicity in Rat Hepatocytes. Toxicological Sciences 158:2, pages 412-430.
Crossref
Michael L. Dourson, Jeri Higginbotham, Jeff Crum, Heather Burleigh-Flayer, Patricia Nance, Norman D. Forsberg, Mark Lafranconi & John Reichard. (2017) Update: Mode of action (MOA) for liver tumors induced by oral exposure to 1,4-dioxane. Regulatory Toxicology and Pharmacology 88, pages 45-55.
Crossref
Jose V. Tarazona, Daniele Court-Marques, Manuela Tiramani, Hermine Reich, Rudolf Pfeil, Frederique Istace & Federica Crivellente. (2017) Glyphosate toxicity and carcinogenicity: a review of the scientific basis of the European Union assessment and its differences with IARC. Archives of Toxicology 91:8, pages 2723-2743.
Crossref
Alicja Mortensen, Fernando Aguilar, Riccardo Crebelli, Alessandro Di Domenico, Birgit Dusemund, Maria Jose Frutos, Pierre Galtier, David Gott, Ursula Gundert‐Remy, Claude Lambré, Jean‐Charles Leblanc, Oliver Lindtner, Peter Moldeus, Pasquale Mosesso, Agneta Oskarsson, Dominique Parent‐Massin, Ivan Stankovic, Ine Waalkens‐Berendsen, Rudolf Antonius Woutersen, Matthew Wright, Piet van den Brandt, Cristina Fortes, Leonardo Merino, Fidel Toldrà, Davide Arcella, Anna Christodoulidou, José Cortinas Abrahantes, Federica Barrucci, Ana Garcia, Fabiola Pizzo, Dario Battacchi & Maged Younes. (2017) Re‐evaluation of potassium nitrite (E 249) and sodium nitrite (E 250) as food additives. EFSA Journal 15:6.
Crossref
Tomoya Yamada, Miwa Kondo, Kaori Miyata, Keiko Ogata, Masahiko Kushida, Kayo Sumida, Satoshi Kawamura, Thomas G. Osimitz, Brian G. Lake & Samuel M. Cohen. (2017) An Evaluation of the Human Relevance of the Lung Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action. Toxicological Sciences 157:2, pages 465-486.
Crossref
Richard A. Becker, Vicki Dellarco, Jennifer Seed, Joel M. Kronenberg, Bette Meek, Jennifer Foreman, Christine Palermo, Chris Kirman, Igor Linkov, Rita Schoeny, Michael Dourson, Lynn H. Pottenger & Mary K. Manibusan. (2017) Quantitative weight of evidence to assess confidence in potential modes of action. Regulatory Toxicology and Pharmacology 86, pages 205-220.
Crossref
Kerry L. Dearfield, B. Bhaskar Gollapudi, Jeffrey C. Bemis, R. Daniel Benz, George R. Douglas, Rosalie K. Elespuru, George E. Johnson, David J. Kirkland, Matthew J. LeBaron, Albert P. Li, Francesco Marchetti, Lynn H. Pottenger, Emiel Rorije, Jennifer Y. Tanir, Veronique Thybaud, Jan van Benthem, Carole L. Yauk, Errol Zeiger & Mirjam Luijten. (2016) Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations. Environmental and Molecular Mutagenesis 58:5, pages 264-283.
Crossref
Thomas Hartung, Rex E. FitzGerald, Paul Jennings, Gary R. MiramsManuel C. Peitsch, Amin Rostami-HodjeganImran Shah, Martin F. Wilks & Shana J. Sturla. (2017) Systems Toxicology: Real World Applications and Opportunities. Chemical Research in Toxicology 30:4, pages 870-882.
Crossref
M.E. (Bette) Meek. (2017) AOPs in hazard characterization for human health. Current Opinion in Toxicology 3, pages 80-86.
Crossref
Noffisat Oki, Jeremy Leonard, Mark Nelms, Shannon Bell, Yu-Mei Tan, Lyle Burgoon & Stephen Edwards. 2017. Computational Systems Pharmacology and Toxicology. Computational Systems Pharmacology and Toxicology 60 88 .
Julie Goodman & Heather Lynch. (2017) Improving the International Agency for Research on Cancer's consideration of mechanistic evidence. Toxicology and Applied Pharmacology 319, pages 39-46.
Crossref
Anna Bal-Price, Pamela J. Lein, Kimberly P. Keil, Sunjay Sethi, Timothy Shafer, Marta Barenys, Ellen Fritsche, Magdalini Sachana & M.E. (Bette) Meek. (2017) Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity. NeuroToxicology 59, pages 240-255.
Crossref
Katherine K Coady, Ronald C Biever, Nancy D Denslow, Melanie Gross, Patrick D Guiney, Henrik Holbech, Natalie K Karouna-Renier, Ioanna Katsiadaki, Hank Krueger, Steven L Levine, Gerd Maack, Mike Williams, Jeffrey C Wolf & Gerald T Ankley. (2017) Current limitations and recommendations to improve testing for the environmental assessment of endocrine active substances. Integrated Environmental Assessment and Management 13:2, pages 302-316.
Crossref
Yu Okuda, Masahiko KushidaHiroko KikumotoYoshimasa Nakamura, Hashihiro HiguchiSatoshi KawamuraSamuel M. Cohen, Brian G. Lake & Tomoya Yamada. (2017) Evaluation of the human relevance of the constitutive androstane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin. The Journal of Toxicological Sciences 42:6, pages 773-788.
Crossref
Christian Strupp, Werner Bomann, Samuel M. Cohen & Klaus Weber. (2016) Relationship of Metabolism and Cell Proliferation to the Mode of Action of Fluensulfone-Induced Mouse Lung Tumors. II: Additional Mechanistic Studies. Toxicological Sciences 154:2, pages 296-308.
Crossref
Alan R. Boobis, Samuel M. Cohen, Vicki L. Dellarco, John E. Doe, Penelope A. Fenner-Crisp, Angelo Moretto, Timothy P. Pastoor, Rita S. Schoeny, Jennifer G. Seed & Douglas C. Wolf. (2016) Classification schemes for carcinogenicity based on hazard-identification have become outmoded and serve neither science nor society. Regulatory Toxicology and Pharmacology 82, pages 158-166.
Crossref
N. Roth & P. Ciffroy. (2016) A critical review of frameworks used for evaluating reliability and relevance of (eco)toxicity data: Perspectives for an integrated eco-human decision-making framework. Environment International 95, pages 16-29.
Crossref
George Papamokos & Ilona Silins. (2016) Combining QSAR Modeling and Text-Mining Techniques to Link Chemical Structures and Carcinogenic Modes of Action. Frontiers in Pharmacology 07.
Crossref
Penelope A. Fenner-Crisp & Vicki L. Dellarco. (2016) Key Elements for Judging the Quality of a Risk Assessment. Environmental Health Perspectives 124:8, pages 1127-1135.
Crossref
Xavier Palazzi, John E. Burkhardt, Henri Caplain, Vicki Dellarco, Pierluigi Fant, John R. Foster, Sabine Francke, Paul Germann, Sibylle Gröters, Takanori Harada, Johannes Harleman, Kosei Inui, Wolfgang Kaufmann, Barbara Lenz, Hirofumi Nagai, Gabriele Pohlmeyer-Esch, Agnes Schulte, Mikala Skydsgaard, Lindsay Tomlinson, Charles E. Wood & Midori Yoshida. (2016) Characterizing “Adversity” of Pathology Findings in Nonclinical Toxicity Studies. Toxicologic Pathology 44:6, pages 810-824.
Crossref
Richard Judson, Keith Houck, Matt Martin, Ann M. Richard, Thomas B. Knudsen, Imran Shah, Stephen Little, John Wambaugh, R. Woodrow Setzer, Parth Kothya, Jimmy Phuong, Dayne Filer, Doris Smith, David Reif, Daniel Rotroff, Nicole Kleinstreuer, Nisha Sipes, Menghang Xia, Ruili Huang, Kevin Crofton & Russell S. Thomas. (2016) Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space . Toxicological Sciences 152:2, pages 323-339.
Crossref
Kurt A Gust, Zachary A Collier, Michael L Mayo, Jacob K Stanley, Ping Gong & Mark A Chappell. (2016) Limitations of toxicity characterization in life cycle assessment: Can adverse outcome pathways provide a new foundation?. Integrated Environmental Assessment and Management 12:3, pages 580-590.
Crossref
Jean Lou C. M. Dorne, Bernard Bottex, Caroline Merten, Andrea Germini, Nikolaos Georgiadis, Elisa Aiassa, Laura Martino, Lorenz Rhomberg, Harvey J. Clewell, Matthias Greiner, Glenn W. Suter, Maurice Whelan, Andrew D. M. Hart, Derek Knight, Prabhat Agarwal, Maged Younes, Jan Alexander & Anthony R. Hardy. (2016) Weighing evidence and assessing uncertainties. EFSA Journal 14.
Crossref
K. Nadira De Abrew, Raghunandan M. Kainkaryam, Yuqing K. Shan, Gary J. Overmann, Raja S. Settivari, Xiaohong Wang, Jun Xu, Rachel L. Adams, Jay P. Tiesman, Edward W. Carney, Jorge M. Naciff & George P. Daston. (2016) Grouping 34 Chemicals Based on Mode of Action Using Connectivity Mapping. Toxicological Sciences 151:2, pages 447-461.
Crossref
Christopher J. Borgert, Richard A. Becker, Betsy D. Carlton, Mark Hanson, Patricia L. Kwiatkowski, Mary Sue Marty, Lynn S. McCarty, Terry F. Quill, Keith Solomon, Glen Van Der Kraak, Raphael J. Witorsch & Kun Don Yi. (2016) Does GLP enhance the quality of toxicological evidence for regulatory decisions?: TABLE 1.. Toxicological Sciences 151:2, pages 206-213.
Crossref
R. Philip Yeager, Mary Kushman, Susan Chemerynski, Roxana Weil, Xin Fu, Marcella White, Priscilla Callahan-Lyon & Hans Rosenfeldt. (2016) Proposed Mode of Action for Acrolein Respiratory Toxicity Associated with Inhaled Tobacco Smoke. Toxicological Sciences 151:2, pages 347-364.
Crossref
Katie Paul Friedman, Eric D. Watt, Michael W. Hornung, Joan M. Hedge, Richard S. Judson, Kevin M. Crofton, Keith A. Houck & Steven O. Simmons. (2016) Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors Within the ToxCast Phase I and II Chemical Libraries. Toxicological Sciences 151:1, pages 160-180.
Crossref
C.R. Kirman, B. Hughes, R.A. Becker & S.M. Hays. (2016) Derivation of a No-significant-risk-level (NSRL) for dermal exposures to diethanolamine. Regulatory Toxicology and Pharmacology 76, pages 137-151.
Crossref
Nicole C. Kleinstreuer, Kristie Sullivan, David Allen, Stephen Edwards, Donna L. Mendrick, Michelle Embry, Joanna Matheson, J. Craig Rowlands, Sharon Munn, Elizabeth Maull & Warren Casey. (2016) Adverse outcome pathways: From research to regulation scientific workshop report. Regulatory Toxicology and Pharmacology 76, pages 39-50.
Crossref
Nancy B. Beck, Richard A. Becker, Neeraja Erraguntla, William H. Farland, Roberta L. Grant, George Gray, Christopher Kirman, Judy S. LaKind, R. Jeffrey Lewis, Patricia Nance, Lynn H. Pottenger, Susan L. Santos, Stephanie Shirley, Ted Simon & Michael L. Dourson. (2016) Approaches for describing and communicating overall uncertainty in toxicity characterizations: U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS) as a case study. Environment International 89-90, pages 110-128.
Crossref
Zachary A. Collier, Kurt A. Gust, Benette Gonzalez-Morales, Ping Gong, Mitchell S. Wilbanks, Igor Linkov & Edward J. Perkins. (2016) A weight of evidence assessment approach for adverse outcome pathways. Regulatory Toxicology and Pharmacology 75, pages 46-57.
Crossref
Samuel M. Cohen & Lora L. Arnold. (2016) Critical role of toxicologic pathology in a short-term screen for carcinogenicity. Journal of Toxicologic Pathology 29:4, pages 215-227.
Crossref
Daniel A. Vallero. 2016. Environmental Biotechnology. Environmental Biotechnology 507 521 .
Elisabet Berggren, Patric Amcoff, Romualdo Benigni, Karen Blackburn, Edward Carney, Mark Cronin, Hubert Deluyker, Francoise Gautier, Richard S. Judson, Georges E.N. Kass, Detlef Keller, Derek Knight, Werner Lilienblum, Catherine Mahony, Ivan Rusyn, Terry Schultz, Michael Schwarz, Gerrit Schüürmann, Andrew White, Julien Burton, Alfonso M. Lostia, Sharon Munn & Andrew Worth. (2015) Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making. Environmental Health Perspectives 123:12, pages 1232-1240.
Crossref
James C. LambIVIV, Paolo Boffetta, Warren G. Foster, Julie E. Goodman, Karyn L. Hentz, Lorenz R. Rhomberg, Jane Staveley, Gerard Swaen, Glen Van Der Kraak & Amy L. Williams. (2015) Comments on the opinions published by Bergman et al. (2015) on Critical Comments on the WHO-UNEP State of the Science of Endocrine Disrupting Chemicals (Lamb et al., 2014). Regulatory Toxicology and Pharmacology 73:3, pages 754-757.
Crossref
Edward J. Perkins, Philipp Antczak, Lyle Burgoon, Francesco Falciani, Natàlia Garcia-Reyero, Steve Gutsell, Geoff Hodges, Aude Kienzler, Dries Knapen, Mary McBride & Catherine Willett. (2015) Adverse Outcome Pathways for Regulatory Applications: Examination of Four Case Studies With Different Degrees of Completeness and Scientific Confidence. Toxicological Sciences 148:1, pages 14-25.
Crossref
Robyn L. Prueitt, Joel M. Cohen & Julie E. Goodman. (2015) Evaluation of atherosclerosis as a potential mode of action for cardiovascular effects of particulate matter. Regulatory Toxicology and Pharmacology 73:2, pages S1-S15.
Crossref
P. Marx-Stoelting, A. Braeuning, T. Buhrke, A. Lampen, L. Niemann, M. Oelgeschlaeger, S. Rieke, F. Schmidt, T. Heise, R. Pfeil & R. Solecki. (2015) Application of omics data in regulatory toxicology: report of an international BfR expert workshop. Archives of Toxicology 89:11, pages 2177-2184.
Crossref
T. Heise, F. Schmidt, C. Knebel, S. Rieke, W. Haider, R. Pfeil, C. Kneuer, L. Niemann & P. Marx-Stoelting. (2014) Hepatotoxic effects of (tri)azole fungicides in a broad dose range. Archives of Toxicology 89:11, pages 2105-2117.
Crossref
. (2015) Risk assessment for peri- and post-menopausal women taking food supplements containing isolated isoflavones. EFSA Journal 13:10, pages 4246.
Crossref
Richard A. Becker, Grace Patlewicz, Ted W. Simon, J. Craig Rowlands & Robert A. Budinsky. (2015) The adverse outcome pathway for rodent liver tumor promotion by sustained activation of the aryl hydrocarbon receptor. Regulatory Toxicology and Pharmacology 73:1, pages 172-190.
Crossref
Mary Sue Marty, Sabitha Papineni, Katherine K. Coady, Reza J. Rasoulpour, Lynn H. Pottenger & David L. Eisenbrandt. (2015) Pronamide: Weight of evidence for potential estrogen, androgen or thyroid effects. Regulatory Toxicology and Pharmacology 72:2, pages 405-422.
Crossref
Lorenz Rhomberg. (2014) Hypothesis‐Based Weight of Evidence: An Approach to Assessing Causation and its Application to Regulatory Toxicology. Risk Analysis 35:6, pages 1114-1124.
Crossref
M.E. (Bette) Meek & John C. Lipscomb. (2015) Gaining acceptance for the use of in vitro toxicity assays and QIVIVE in regulatory risk assessment. Toxicology 332, pages 112-123.
Crossref
Nikolai L. Chepelev, Ivy D. Moffat, Wayne J. Bowers & Carole L. Yauk. (2015) Neurotoxicity may be an overlooked consequence of benzo[a]pyrene exposure that is relevant to human health risk assessment. Mutation Research/Reviews in Mutation Research 764, pages 64-89.
Crossref
M.E. Bette Meek. 2015. Hamilton & Hardy's Industrial Toxicology. Hamilton & Hardy's Industrial Toxicology 1129 1134 .
Steven P. BradburyChristine L. RussomPatricia K. SchmiederTerry W. SchultzRobert DiderichCharles M. Auer. (2015) Advancing Computational Toxicology in a Regulatory Setting: A Selected Review of the Accomplishments of Gilman D. Veith (1944–2013). Applied In Vitro Toxicology 1:1, pages 16-25.
Crossref
C. Terry, R.J. Rasoulpour, S. Knowles & R. Billington. (2015) Utilizing relative potency factors (RPF) and threshold of toxicological concern (TTC) concepts to assess hazard and human risk assessment profiles of environmental metabolites: A case study. Regulatory Toxicology and Pharmacology 71:2, pages 301-317.
Crossref
Randall Lutter, Linda Abbott, Rick Becker, Chris Borgert, Ann Bradley, Gail Charnley, Susan Dudley, Alan Felsot, Nancy Golden, George Gray, Daland Juberg, Mary Mitchell, Nancy Rachman, Lorenz Rhomberg, Keith Solomon, Stephen Sundlof & Kate Willett. (2015) Improving Weight of Evidence Approaches to Chemical Evaluations. Risk Analysis 35:2, pages 186-192.
Crossref
Natàlia Garcia-Reyero. (2014) Are Adverse Outcome Pathways Here to Stay?. Environmental Science & Technology 49:1, pages 3-9.
Crossref
Gunnar F. Nordberg & Bruce A. Fowler. 2015. Handbook on the Toxicology of Metals. Handbook on the Toxicology of Metals 461 486 .
Todd Bourcier & Denis Roy. 2015. Genotoxicity and Carcinogenicity Testing of Pharmaceuticals. Genotoxicity and Carcinogenicity Testing of Pharmaceuticals 159 182 .
Edward Perkins, Natàlia Garcia-Reyero, Stephen Edwards, Clemens Wittwehr, Daniel Villeneuve, David Lyons & Gerald Ankley. 2015. Computational Systems Toxicology. Computational Systems Toxicology 1 26 .
Daniel L. Villeneuve, Doug Crump, Natàlia Garcia-Reyero, Markus Hecker, Thomas H. Hutchinson, Carlie A. LaLone, Brigitte Landesmann, Teresa Lettieri, Sharon Munn, Malgorzata Nepelska, Mary Ann Ottinger, Lucia Vergauwen & Maurice Whelan. (2014) Adverse Outcome Pathway Development II: Best Practices. Toxicological Sciences 142:2, pages 321-330.
Crossref
Daniel L. Villeneuve, Doug Crump, Natàlia Garcia-Reyero, Markus Hecker, Thomas H. Hutchinson, Carlie A. LaLone, Brigitte Landesmann, Teresa Lettieri, Sharon Munn, Malgorzata Nepelska, Mary Ann Ottinger, Lucia Vergauwen & Maurice Whelan. (2014) Adverse Outcome Pathway (AOP) Development I: Strategies and Principles. Toxicological Sciences 142:2, pages 312-320.
Crossref
P. Marx-Stoelting, L. Niemann, V. Ritz, B. Ulbrich, A. Gall, K.I. Hirsch-Ernst, R. Pfeil & R. Solecki. (2014) Assessment of three approaches for regulatory decision making on pesticides with endocrine disrupting properties. Regulatory Toxicology and Pharmacology 70:3, pages 590-604.
Crossref
Paul Jennings, Michael Schwarz, Brigitte Landesmann, Silvia Maggioni, Marina Goumenou, David Bower, Martin O. Leonard & Jeffrey S. Wiseman. (2014) SEURAT-1 liver gold reference compounds: a mechanism-based review. Archives of Toxicology 88:12, pages 2099-2133.
Crossref
Christine L. Russom, Carlie A. LaLone, Daniel L. Villeneuve & Gerald T. Ankley. (2014) Development of an adverse outcome pathway for acetylcholinesterase inhibition leading to acute mortality. Environmental Toxicology and Chemistry 33:10, pages 2157-2169.
Crossref
Ann de Peyster & Ellen Mihaich. (2014) Hypothesis-driven weight of evidence analysis to determine potential endocrine activity of MTBE. Regulatory Toxicology and Pharmacology 69:3, pages 348-370.
Crossref
Lutz Edler, Andy Hart, Peter Greaves, Philip Carthew, Myriam Coulet, Alan Boobis, Gary M. Williams & Benjamin Smith. (2014) Selection of appropriate tumour data sets for Benchmark Dose Modelling (BMD) and derivation of a Margin of Exposure (MoE) for substances that are genotoxic and carcinogenic: Considerations of biological relevance of tumour type, data quality and uncertainty assessment. Food and Chemical Toxicology 70, pages 264-289.
Crossref
Richard Judson, Keith Houck, Matt Martin, Thomas Knudsen, Russell S. Thomas, Nisha Sipes, Imran Shah, John Wambaugh & Kevin Crofton. (2014) In Vitro and Modelling Approaches to Risk Assessment from the U.S. Environmental Protection Agency ToxCast Programme . Basic & Clinical Pharmacology & Toxicology 115:1, pages 69-76.
Crossref
M. E. (Bette) Meek, Christine M. Palermo, Ammie N. Bachman, Colin M. North & R. Jeffrey Lewis. (2014) Mode of action human relevance (species concordance) framework: Evolution of the Bradford Hill considerations and comparative analysis of weight of evidence. Journal of Applied Toxicology 34:6, pages 595-606.
Crossref
. (2014) Modern methodologies and tools for human hazard assessment of chemicals. EFSA Journal 12:4.
Crossref
Kevin Fournier, Philippe Glorennec & Nathalie Bonvallot. (2014) An exposure-based framework for grouping pollutants for a cumulative risk assessment approach: Case study of indoor semi-volatile organic compounds. Environmental Research 130, pages 20-28.
Crossref
Puttappa R. Dodmane, Lora L. Arnold & Samuel M. Cohen. (2014) Mode of action for inorganic arsenic toxicity and carcinogenesis. Chinese Science Bulletin 59:11, pages 1078-1082.
Crossref
Katie B. Paul, Joan M. Hedge, Daniel M. Rotroff, Michael W. Hornung, Kevin M. Crofton & Steven O. Simmons. (2014) Development of a Thyroperoxidase Inhibition Assay for High-Throughput Screening. Chemical Research in Toxicology 27:3, pages 387-399.
Crossref
Ted Simon. 2014. Environmental Risk Assessment. Environmental Risk Assessment 1 48 .
Stephanie Melching-Kollmuß, Karma C. Fussell, Roland Buesen, Martina Dammann, Steffen Schneider, Henk Tennekes & Bennard van Ravenzwaay. (2014) Anti-androgenicity can only be evaluated using a weight of evidence approach. Regulatory Toxicology and Pharmacology 68:1, pages 175-192.
Crossref
David A. Brott, Håkan A.S. Andersson, Jane Stewart, Lorna Ewart, Greg Christoph, Johannes Harleman, Duncan Armstrong & Lewis B. Kinter. (2014) A peripherally restricted P2Y 12 receptor antagonist altered rat tumor incidences with no human relevance: Mode of action consistent with dopamine agonism. Toxicology Reports 1, pages 1202-1212.
Crossref
Yu-Mei Tan, Daniel T. Chang, Martin Phillips, Stephen Edwards, Christopher M. Grulke, Michael-Rock Goldsmith, Jon Sobus, Rory Conolly, Rogelio Tornero-Velez & Curtis C. Dary. 2014. Biomarkers in Toxicology. Biomarkers in Toxicology 1039 1055 .
C. Willett. 2014. Encyclopedia of Toxicology. Encyclopedia of Toxicology 95 99 .
M. E. Meek, A. Boobis, I. Cote, V. Dellarco, G. Fotakis, S. Munn, J. Seed & C. Vickers. (2013) New developments in the evolution and application of the WHO/IPCS framework on mode of action/species concordance analysis. Journal of Applied Toxicology 34:1, pages 1-18.
Crossref
Daniel Villeneuve, David C. Volz, Michelle R. Embry, Gerald T. Ankley, Scott E. Belanger, Marc Léonard, Kristin Schirmer, Robert Tanguay, Lisa Truong & Leah Wehmas. (2013) Investigating Alternatives to the fish early‐life stage test: A strategy for discovering and annotating adverse outcome pathways for early fish development. Environmental Toxicology and Chemistry 33:1, pages 158-169.
Crossref
. (2013) Scientific Opinion on the relevance of dissimilar mode of action and its appropriate application for cumulative risk assessment of pesticides residues in food. EFSA Journal 11:12.
Crossref
Åke Bergman, Anna-Maria Andersson, Georg Becher, Martin van den Berg, Bruce Blumberg, Poul Bjerregaard, Carl-Gustaf Bornehag, Riana Bornman, Ingvar Brandt, Jayne V Brian, Stephanie C Casey, Paul A Fowler, Heloise Frouin, Linda C Giudice, Taisen Iguchi, Ulla Hass, Susan Jobling, Anders Juul, Karen A Kidd, Andreas Kortenkamp, Monica Lind, Olwenn V Martin, Derek Muir, Roseline Ochieng, Nicolas Olea, Leif Norrgren, Erik Ropstad, Peter S Ross, Christina Rudén, Martin Scheringer, Niels Erik Skakkebaek, Olle Söder, Carlos Sonnenschein, Ana Soto, Shanna Swan, Jorma Toppari, Charles R Tyler, Laura N Vandenberg, Anne Marie Vinggaard, Karin Wiberg & R Thomas Zoeller. (2013) Science and policy on endocrine disrupters must not be mixed: a reply to a “common sense” intervention by toxicology journal editors. Environmental Health 12:1.
Crossref
Brigitte Landesmann, Milena Mennecozzi, Elisabet Berggren & Maurice Whelan. (2013) Adverse Outcome Pathway-based Screening Strategies for an Animal-free Safety Assessment of Chemicals. Alternatives to Laboratory Animals 41:6, pages 461-471.
Crossref
Richard W. Lewis. (2013) Risk assessment of ‘endocrine substances’: Guidance on identifying endocrine disruptors. Toxicology Letters 223:3, pages 287-290.
Crossref

Displaying 200 of 283 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.