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Review Article

Sulfa and trimethoprim-like drugs – antimetabolites acting as carbonic anhydrase, dihydropteroate synthase and dihydrofolate reductase inhibitors

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Pages 379-387 | Received 21 Feb 2013, Accepted 15 Mar 2013, Published online: 29 Apr 2013

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Claudiu T. Supuran & Clemente Capasso. (2020) Antibacterial carbonic anhydrase inhibitors: an update on the recent literature. Expert Opinion on Therapeutic Patents 30:12, pages 963-982.
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Giovanna Salbitani, Sonia Del Prete, Francesco Bolinesi, Olga Mangoni, Viviana De Luca, Vincenzo Carginale, William A. Donald, Claudiu T. Supuran, Simona Carfagna & Clemente Capasso. (2020) Use of an immobilised thermostable α-CA (SspCA) for enhancing the metabolic efficiency of the freshwater green microalga Chlorella sorokiniana. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 913-920.
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Ozen Ozensoy Guler, Claudiu. T. Supuran & Clemente Capasso. (2020) Carbonic anhydrase IX as a novel candidate in liquid biopsy. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 255-260.
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Sonia Del Prete, Rosa Merlo, Anna Valenti, Rosanna Mattossovich, Mosè Rossi, Vincenzo Carginale, Claudiu T. Supuran, Giuseppe Perugino & Clemente Capasso. (2019) Thermostability enhancement of the α-carbonic anhydrase from Sulfurihydrogenibium yellowstonense by using the anchoring-and-self-labelling-protein-tag system (ASL). Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 946-954.
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Claudiu T. Supuran & Clemente Capasso. (2018) Biomedical applications of prokaryotic carbonic anhydrases. Expert Opinion on Therapeutic Patents 28:10, pages 745-754.
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Verônica da Silva Cardoso, Alane Beatriz Vermelho, Eduardo Ricci Junior, Igor Almeida Rodrigues, Ana Maria Mazotto & Claudiu T. Supuran. (2018) Antileishmanial activity of sulphonamide nanoemulsions targeting the β-carbonic anhydrase from Leishmania species. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 850-857.
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Alane Beatriz Vermelho, Verônica da Silva Cardoso, Eduardo Ricci Junior, Elisabete Pereira dos Santos & Claudiu T. Supuran. (2018) Nanoemulsions of sulfonamide carbonic anhydrase inhibitors strongly inhibit the growth of Trypanosoma cruzi. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 139-146.
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Daniela Vullo, Sonia Del Prete, Sameh M. Osman, Fatmah A. S. Alasmary, Zeid AlOthman, William A. Donald, Clemente Capasso & Claudiu T. Supuran. (2018) Comparison of the amine/amino acid activation profiles of the β- and γ-carbonic anhydrases from the pathogenic bacterium Burkholderia pseudomallei. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 25-30.
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Claudiu T. Supuran. (2017) Advances in structure-based drug discovery of carbonic anhydrase inhibitors. Expert Opinion on Drug Discovery 12:1, pages 61-88.
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P. V. Sri Ramya, Srinivas Angapelly, Andrea Angeli, Chander Singh Digwal, Mohammed Arifuddin, Bathini Nagendra Babu, Claudiu T. Supuran & Ahmed Kamal. (2017) Discovery of curcumin inspired sulfonamide derivatives as a new class of carbonic anhydrase isoforms I, II, IX, and XII inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 1274-1281.
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Rajiv Kumar, Vikas Sharma, Silvia Bua, Claudiu T. Supuran & Pawan K. Sharma. (2017) Synthesis and biological evaluation of benzenesulphonamide-bearing 1,4,5-trisubstituted-1,2,3-triazoles possessing human carbonic anhydrase I, II, IV, and IX inhibitory activity. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 1187-1194.
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Morteza Abdoli, Andrea Angeli, Murat Bozdag, Fabrizio Carta, Ali Kakanejadifard, Hamid Saeidian & Claudiu T. Supuran. (2017) Synthesis and carbonic anhydrase I, II, VII, and IX inhibition studies with a series of benzo[d]thiazole-5- and 6-sulfonamides. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 1071-1078.
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Rosa Perfetto, Sonia Del Prete, Daniela Vullo, Vincenzo Carginale, Giovanni Sansone, Carmela M. A. Barone, Mosè Rossi, Fatmah A. S. Alasmary, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran & Clemente Capasso. (2017) Cloning, expression and purification of the α-carbonic anhydrase from the mantle of the Mediterranean mussel, Mytilus galloprovincialis. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 1029-1035.
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Daniela De Vita, Andrea Angeli, Fabiana Pandolfi, Martina Bortolami, Roberta Costi, Roberto Di Santo, Elisabetta Suffredini, Mariangela Ceruso, Sonia Del Prete, Clemente Capasso, Luigi Scipione & Claudiu T. Supuran. (2017) Inhibition of the α-carbonic anhydrase from Vibrio cholerae with amides and sulfonamides incorporating imidazole moieties. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 798-804.
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Rosa Perfetto, Sonia Del Prete, Daniela Vullo, Giovanni Sansone, Carmela Barone, Mosè Rossi, Claudiu T. Supuran & Clemente Capasso. (2017) Biochemical characterization of the native α-carbonic anhydrase purified from the mantle of the Mediterranean mussel, Mytilus galloprovincialis. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 632-639.
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Melissa D’Ascenzio, Paolo Guglielmi, Simone Carradori, Daniela Secci, Rosalba Florio, Adriano Mollica, Mariangela Ceruso, Atilla Akdemir, Anatoly P. Sobolev & Claudiu T. Supuran. (2017) Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 51-59.
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Erol Licsandru, Muhammet Tanc, Istvan Kocsis, Mihail Barboiu & Claudiu T. Supuran. (2017) A class of carbonic anhydrase I – selective activators. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 37-46.
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Halise Inci Gul, Zehra Yazici, Muhammet Tanc & Claudiu T. Supuran. (2016) Inhibitory effects of benzimidazole containing new phenolic Mannich bases on human carbonic anhydrase isoforms hCA I and II. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1540-1544.
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Dilan Ozmen Ozgun, Cem Yamali, Halise Inci Gul, Parham Taslimi, Ilhami Gulcin, Telat Yanik & Claudiu T. Supuran. (2016) Inhibitory effects of isatin Mannich bases on carbonic anhydrases, acetylcholinesterase, and butyrylcholinesterase. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1498-1501.
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F. Zehra Küçükbay, Hasan Küçükbay, Muhammet Tanc & Claudiu T. Supuran. (2016) Synthesis and carbonic anhydrase I, II, IV and XII inhibitory properties of N-protected amino acid – sulfonamide conjugates. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1476-1483.
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Leyla Polat Kose, İlhami Gulcin, Alper Yıldırım, Ufuk Atmaca, Murat Çelik, Saleh H. Alwasel & Claudiu T. Supuran. (2016) The human carbonic anhydrase isoenzymes I and II inhibitory effects of some hydroperoxides, alcohols, and acetates. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1248-1253.
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F. Zehra Küçükbay, Nesrin Buğday, Hasan Küçükbay, Muhammet Tanc & Claudiu T. Supuran. (2016) Synthesis, characterization and carbonic anhydrase inhibitory activity of novel benzothiazole derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1221-1225.
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György M. Buzás & Claudiu T. Supuran. (2016) The history and rationale of using carbonic anhydrase inhibitors in the treatment of peptic ulcers. In memoriam Ioan Puşcaş (1932–2015). Journal of Enzyme Inhibition and Medicinal Chemistry 31:4, pages 527-533.
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Claudiu T. Supuran. (2016) How many carbonic anhydrase inhibition mechanisms exist?. Journal of Enzyme Inhibition and Medicinal Chemistry 31:3, pages 345-360.
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Murat Bozdag, Fabrizio Carta, Daniela Vullo, Semra Isik, Zeid AlOthman, Sameh M. Osman, Andrea Scozzafava & Claudiu T. Supuran. (2016) Dithiocarbamates with potent inhibitory activity against the Saccharomyces cerevisiae β-carbonic anhydrase. Journal of Enzyme Inhibition and Medicinal Chemistry 31:1, pages 132-136.
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Andrea Scozzafava, Pınar Kalın, Claudiu T. Supuran, İlhami Gülçin & Saleh H. Alwasel. (2015) The impact of hydroquinone on acetylcholine esterase and certain human carbonic anhydrase isoenzymes (hCA I, II, IX, and XII). Journal of Enzyme Inhibition and Medicinal Chemistry 30:6, pages 941-946.
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Joanna Ombouma, Daniela Vullo, Stephan Köhler, Pascal Dumy, Claudiu T. Supuran & Jean-Yves Winum. (2015) N-glycosyl-N-hydroxysulfamides as potent inhibitors of Brucella suis carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry 30:6, pages 1010-1012.
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Namrata Singasane, Prashant S. Kharkar, Mariangela Ceruso, Claudiu T. Supuran & Mrunmayee P. Toraskar. (2015) Inhibition of carbonic anhydrase isoforms I, II, IX and XII with Schiff’s bases incorporating iminoureido moieties. Journal of Enzyme Inhibition and Medicinal Chemistry 30:6, pages 901-907.
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Viviana De Luca, Sonia Del Prete, Vincenzo Carginale, Daniela Vullo, Claudiu T. Supuran & Clemente Capasso. (2015) A failed tentative to design a super carbonic anhydrase having the biochemical properties of the most thermostable CA (SspCA) and the fastest (SazCA) enzymes. Journal of Enzyme Inhibition and Medicinal Chemistry 30:6, pages 989-994.
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Daniela Vullo, Semra Isik, Murat Bozdag, Fabrizio Carta & Claudiu T. Supuran. (2015) 7-Amino-3,4-dihydro-1H-quinolin-2-one, a compound similar to the substituted coumarins, inhibits α-carbonic anhydrases without hydrolysis of the lactam ring. Journal of Enzyme Inhibition and Medicinal Chemistry 30:5, pages 773-777.
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Claudiu T Supuran. (2015) Nanoparticles for controlled release of anti-biofilm agents WO2014130994 (A1): a patent evaluation. Expert Opinion on Therapeutic Patents 25:8, pages 945-948.
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Ahmed M. Alafeefy, Mariangela Ceruso, Abdul-Malek S. Al-Tamimi, Sonia Del Prete, Claudiu T. Supuran & Clemente Capasso. (2015) Inhibition studies of quinazoline-sulfonamide derivatives against the γ-CA (PgiCA) from the pathogenic bacterium, Porphyromonas gingivalis. Journal of Enzyme Inhibition and Medicinal Chemistry 30:4, pages 592-596.
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Ahmed M. Alafeefy, Mariangela Ceruso, Nabila A. Al-Jaber, Seppo Parkkila, Alane Beatriz Vermelho & Claudiu T. Supuran. (2015) A new class of quinazoline-sulfonamides acting as efficient inhibitors against the α-carbonic anhydrase from Trypanosoma cruzi. Journal of Enzyme Inhibition and Medicinal Chemistry 30:4, pages 581-585.
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Claudiu T Supuran & Clemente Capasso. (2015) The η-class carbonic anhydrases as drug targets for antimalarial agents. Expert Opinion on Therapeutic Targets 19:4, pages 551-563.
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Viviana De Luca, Sonia Del Prete, Claudiu T. Supuran & Clemente Capasso. (2015) Protonography, a new technique for the analysis of carbonic anhydrase activity. Journal of Enzyme Inhibition and Medicinal Chemistry 30:2, pages 277-282.
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Mina Ghiasi, Samira Gholami & Samira Nasiri. (2021) QM study of carbon dioxide (CO2) and carbonyl sulfide (COS) degradation by cluster model of Carbonic anhydrase enzyme. Computational and Theoretical Chemistry 1199, pages 113188.
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Claudiu T. Supuran & Clemente Capasso. (2021) A Highlight on the Inhibition of Fungal Carbonic Anhydrases as Drug Targets for the Antifungal Armamentarium. International Journal of Molecular Sciences 22:9, pages 4324.
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Moataz Shaldam, Wagdy M. Eldehna, Alessio Nocentini, Zainab M. Elsayed, Tamer M. Ibrahim, Rofaida Salem, Ramadan A. El-Domany, Clemente Capasso, Hatem A. Abdel-Aziz & Claudiu T. Supuran. (2021) Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors. European Journal of Medicinal Chemistry 216, pages 113283.
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T. My-Thao Nguyen, T. Anh-Thu Nguyen, N. Tuong-Van Pham, Quang-Vi Ly, T. Thuy-Quynh Tran, Thi-Dan Thach, Cam-Lai Nguyen, Kien-Sam Banh, Van-Dung Le, Linh-Phuong Nguyen, Dinh-Truong Nguyen, Chi-Hien Dang & Thanh-Danh Nguyen. (2021) Biosynthesis of metallic nanoparticles from waste Passiflora edulis peels for their antibacterial effect and catalytic activity. Arabian Journal of Chemistry 14:4, pages 103096.
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Shasank S. Swain, Sudhir K. Paidesetty & Rabindra N. Padhy. (2020) Phytochemical conjugation as a potential semisynthetic approach toward reactive and reuse of obsolete sulfonamides against pathogenic bacteria. Drug Development Research 82:2, pages 149-166.
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Cristina Campestre, Viviana De Luca, Simone Carradori, Rossella Grande, Vincenzo Carginale, Andrea Scaloni, Claudiu T. Supuran & Clemente Capasso. (2021) Carbonic Anhydrases: New Perspectives on Protein Functional Role and Inhibition in Helicobacter pylori. Frontiers in Microbiology 12.
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Drashti G. Daraji, Dhanji P. Rajani, Smita D. Rajani, Edwin A. Pithawala, Sivaraman Jayanthi & Hitesh D. Patel. (2021) Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme. Bioorganic & Medicinal Chemistry Letters 36, pages 127819.
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Raffaella Menegheti Mainardi, Arthur Roberto da Costa, Roberta Torres Chideroli, Leonardo Mantovani Favero, Amauri Alcindo Alfieri & Ulisses de Pádua Pereira. (2021) Resistance profile and virulence characterization of Escherichia coli isolated from diarrheic neonatal farm animals. Semina: Ciências Agrárias 42:2, pages 735-746.
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Viviana De Luca, Andrea Petreni, Alessio Nocentini, Andrea Scaloni, Claudiu T. Supuran & Clemente Capasso. (2021) Effect of Sulfonamides and Their Structurally Related Derivatives on the Activity of ι-Carbonic Anhydrase from Burkholderia territorii. International Journal of Molecular Sciences 22:2, pages 571.
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Sunil Shetty & Umesh Varshney. (2021) Regulation of translation by one-carbon metabolism in bacteria and eukaryotic organelles. Journal of Biological Chemistry 296, pages 100088.
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Clemente Capasso & Claudiu T. Supuran. 2022. Antiprotozoal Drug Development and Delivery. Antiprotozoal Drug Development and Delivery 241 258 .
Lokesh Ravi, Shabari Girish, M. Harshini & B.K. Anirudh Sreenivas. (2020) β-Sitosterol: An Antibacterial Agent in Aquaculture Management of Vibrio Infections. Journal of Pure and Applied Microbiology 14:4, pages 2699-2714.
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Peixuan Li, Xiaoyun Qin, Fangbiao Tao & Kun Huang. (2020) Maternal exposure to sulfonamides and adverse pregnancy outcomes: A systematic review and meta-analysis. PLOS ONE 15:12, pages e0242523.
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Zuhal Alım, Zeynep Köksal & Muhammet Karaman. (2020) Evaluation of some thiophene-based sulfonamides as potent inhibitors of carbonic anhydrase I and II isoenzymes isolated from human erythrocytes by kinetic and molecular modelling studies. Pharmacological Reports 72:6, pages 1738-1748.
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Aiten M. Soliman, Mostafa M. Ghorab, Silvia Bua & Claudiu T. Supuran. (2020) Iodoquinazolinones bearing benzenesulfonamide as human carbonic anhydrase I, II, IX and XII inhibitors: Synthesis, biological evaluation and radiosensitizing activity. European Journal of Medicinal Chemistry 200, pages 112449.
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James A. Ezugwu, Uchechukwu C. Okoro, Mercy A. Ezeokonkwo, Chinaraju Bhimapaka, Sunday N. Okafor, David I. Ugwu & Daniel I. Ugwuja. (2020) Synthesis and biological evaluation of Val–Val dipeptide–sulfonamide conjugates. Archiv der Pharmazie 353:7, pages 2000074.
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Sonia Del Prete, Viviana De Luca, Silvia Bua, Alessio Nocentini, Vincenzo Carginale, Claudiu T. Supuran & Clemente Capasso. (2020) The Effect of Substituted Benzene-Sulfonamides and Clinically Licensed Drugs on the Catalytic Activity of CynT2, a Carbonic Anhydrase Crucial for Escherichia coli Life Cycle. International Journal of Molecular Sciences 21:11, pages 4175.
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Noman Javid, Rubina Munir, Faryal Chaudhry, Aqeel Imran, Sumera Zaib, Ayesha Muzaffar & Jamshed Iqbal. (2020) Exploiting oxadiazole-sulfonamide hybrids as new structural leads to combat diabetic complications via aldose reductase inhibition. Bioorganic Chemistry 99, pages 103852.
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Sonia Del Prete, Viviana De Luca, Alessio Nocentini, Andrea Scaloni, Margaret D. Mastrolorenzo, Claudiu T. Supuran & Clemente Capasso. (2020) Anion Inhibition Studies of the Beta-Carbonic Anhydrase from Escherichia coli. Molecules 25:11, pages 2564.
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Rasha A. Azzam, Rasha E. Elsayed & Galal H. Elgemeie. (2020) Design, Synthesis, and Antimicrobial Evaluation of a New Series of N -Sulfonamide 2-Pyridones as Dual Inhibitors of DHPS and DHFR Enzymes . ACS Omega 5:18, pages 10401-10414.
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Bahar Yilmaz, Abdullah Tahir Bayrac & Mevlut Bayrakci. (2019) Evaluation of Anticancer Activities of Novel Facile Synthesized Calix[n]arene Sulfonamide Analogs. Applied Biochemistry and Biotechnology 190:4, pages 1484-1497.
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Agnieszka Wróbel, Karolina Arciszewska, Dawid Maliszewski & Danuta Drozdowska. (2019) Trimethoprim and other nonclassical antifolates an excellent template for searching modifications of dihydrofolate reductase enzyme inhibitors. The Journal of Antibiotics 73:1, pages 5-27.
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Riham F. George, Mona F. Said, Silvia Bua & Claudiu T. Supuran. (2020) Synthesis and selective inhibitory effects of some 2-oxindole benzenesulfonamide conjugates on human carbonic anhydrase isoforms CA I, CA II, CA IX and CAXII. Bioorganic Chemistry 95, pages 103514.
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Mostafa M. Ghorab, Aiten M. Soliman, Mansour S. Alsaid & Ahmed A. Askar. (2020) Synthesis, antimicrobial activity and docking study of some novel 4-(4,4-dimethyl-2,6-dioxocyclohexylidene)methylamino derivatives carrying biologically active sulfonamide moiety. Arabian Journal of Chemistry 13:1, pages 545-556.
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Claudiu T. Supuran & Clemente Capasso. 2020. Physiological and Biotechnological Aspects of Extremophiles. Physiological and Biotechnological Aspects of Extremophiles 295 306 .
Baijayantimala Swain, Chander Singh Digwal, Andrea Angeli, Mallika Alvala, Priti Singh, Claudiu T. Supuran & Mohammed Arifuddin. (2019) Synthesis and exploration of 2-morpholino-4-phenylthiazol-5-yl acrylamide derivatives for their effects against carbonic anhydrase I, II, IX and XII isoforms as a non-sulfonamide class of inhibitors. Bioorganic & Medicinal Chemistry 27:21, pages 115090.
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Tian‐Yu Feng, Fa Ren, Qian Fang, Gui‐Chao Dai, Yu Li, Qian Li, Hua‐Ming Xi, Hao Li, Yang‐Yi Hao & Jian‐Hong Hu. (2019) Effects of sulfanilamide on boar sperm quality, bacterial composition, and fertility during liquid storage at 17°C. Animal Science Journal 90:9, pages 1161-1169.
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Wagdy M. Eldehna, Mohamed A. Abdelrahman, Alessio Nocentini, Silvia Bua, Sara T. Al-Rashood, Ghada S. Hassan, Alessandro Bonardi, Abdulrahman A. Almehizia, Hamad M. Alkahtani, Amal Alharbi, Paola Gratteri & Claudiu T. Supuran. (2019) Synthesis, biological evaluation and in silico studies with 4-benzylidene-2-phenyl-5(4H)-imidazolone-based benzenesulfonamides as novel selective carbonic anhydrase IX inhibitors endowed with anticancer activity. Bioorganic Chemistry 90, pages 103102.
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Hamdi Özkan & Bayram Demirci. (2019) Synthesis and Antimicrobial and Antioxidant Activities of Sulfonamide Derivatives Containing Tetrazole and Oxadiazole Rings. Journal of Heterocyclic Chemistry 56:9, pages 2528-2535.
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Yuxin Han, Xiaoxuan Zhou, Yue Qian, Hongjie Hu, Zhuxian Zhou, Xiangrui Liu, Jianbin Tang & Youqing Shen. (2019) Hypoxia-targeting dendritic MRI contrast agent based on internally hydroxy dendrimer for tumor imaging. Biomaterials 213, pages 119195.
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Vinod Kumar Nathan & Parvathi Ammini. (2019) Carbon Dioxide Sequestering Ability of Bacterial Carbonic Anhydrase in a Mangrove Soil Microcosm and Its Bio-mineralization Properties. Water, Air, & Soil Pollution 230:8.
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Xuanhe Ren, Shanyu Tang, Longjia Li, Jiao Li, Helong Liang, Ganzhong Li, Guanyu Yang, Heng Li & Bingxin Yuan. (2019) Surfactant-Type Catalyst for Aerobic Oxidative Coupling of Hydrazine with Thiol in Water. The Journal of Organic Chemistry 84:13, pages 8683-8690.
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Hua Wang, Yang Zhou & Lu Zhang. 2019. Food Microbiology. Food Microbiology 902 926 .
Behnam Rasti, Sargol Mazraedoost, Hanieh Panahi, Mojtaba Falahati & Farnoosh Attar. (2018) New insights into the selective inhibition of the β-carbonic anhydrases of pathogenic bacteria Burkholderia pseudomallei and Francisella tularensis: a proteochemometrics study. Molecular Diversity 23:2, pages 263-273.
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Hina Andleeb, Imtiaz Khan, Antonio Franconetti, Muhammad Nawaz Tahir, Jim Simpson, Shahid Hameed & Antonio Frontera. (2019) Diverse structural assemblies of U-shaped hydrazinyl-sulfonamides: experimental and theoretical analysis of non-covalent interactions stabilizing solid state conformations. CrystEngComm 21:11, pages 1780-1793.
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Sonia Del Prete, Silvia Bua, Fatmah Alasmary, Zeid AlOthman, Sylvie Tambutté, Didier Zoccola, Claudiu Supuran & Clemente Capasso. (2019) Comparison of the Sulfonamide Inhibition Profiles of the α-Carbonic Anhydrase Isoforms (SpiCA1, SpiCA2 and SpiCA3) Encoded by the Genome of the Scleractinian Coral Stylophora pistillata. Marine Drugs 17:3, pages 146.
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Meenakumari Muthuramalingam, John C. White, Tamiko Murphy, Jessica R. Ames & Christina R. Bourne. (2019) The toxin from a ParDE toxin-antitoxin system found in Pseudomonas aeruginosa offers protection to cells challenged with anti-gyrase antibiotics . Molecular Microbiology 111:2, pages 441-454.
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Clemente Capasso & Mihail Barboiu. 2019. Carbonic Anhydrases. Carbonic Anhydrases 495 514 .
Claudiu T. Supuran & Clemente Capasso. 2019. Carbonic Anhydrases. Carbonic Anhydrases 387 417 .
Clemente Capasso. 2019. Carbonic Anhydrases. Carbonic Anhydrases 107 129 .
Xin Huang, Yongqi Chen, Shan Zhen, Lijuan Song, Mingqi Gao, Panke Zhang, Heng Li, Bingxin Yuan & Guanyu Yang. (2018) Cobalt-Catalyzed Aerobic Cross-Dehydrogenative Coupling of C–H and Thiols in Water for C–S Formation. The Journal of Organic Chemistry 83:14, pages 7331-7340.
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Yao-Ting Huang, Jia-Min Chen, Bing-Ching Ho, Zong-Yen Wu, Rita C. Kuo & Po-Yu Liu. (2018) Genome Sequencing and Comparative Analysis of Stenotrophomonas acidaminiphila Reveal Evolutionary Insights Into Sulfamethoxazole Resistance. Frontiers in Microbiology 9.
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Claudiu Supuran. (2018) Carbonic Anhydrases and Metabolism. Metabolites 8:2, pages 25.
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Ethan Hain, Kristine H. Wammer & Lee Blaney. (2018) Comment on “Photodegradation of sulfathiazole under simulated sunlight: Kinetics, photo-induced structural rearrangement, and antimicrobial activities of photoproducts” by Niu et al. [Water Research 124 2017 576–583]. Water Research 131, pages 205-207.
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Sonia Del Prete, Daniela Vullo, Natacha Caminiti-Segonds, Didier Zoccola, Sylvie Tambutté, Claudiu T. Supuran & Clemente Capasso. (2018) Protonography and anion inhibition profile of the α-carbonic anhydrase (CruCA4) identified in the Mediterranean red coral Corallium rubrum. Bioorganic Chemistry 76, pages 281-287.
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Alexander Zhivich. (2017) Fighting bacterial resistance: approaches, challenges, and opportunities in the search for new antibiotics.Part 1. Antibiotics used in clinical practice: mechanisms of action and the development of bacterial resistance. Microbiology Independent Research Journal (MIR Journal) 4:1.
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Claudiu Supuran & Clemente Capasso. (2017) An Overview of the Bacterial Carbonic Anhydrases. Metabolites 7:4, pages 56.
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Akın Akıncıoğlu, Ebutalib Kocaman, Hülya Akıncıoğlu, Ramin Ekhteiari Salmas, Serdar Durdagi, İlhami Gülçin, Claudiu T. Supuran & Süleyman Göksu. (2017) The synthesis of novel sulfamides derived from β-benzylphenethylamines as acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase enzymes inhibitors. Bioorganic Chemistry 74, pages 238-250.
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Claudiu Supuran. (2017) Special Issue: Sulfonamides. Molecules 22:10, pages 1642.
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Sonia Del Prete, Daniela Vullo, Sameh M. Osman, Zeid AlOthman, William A. Donald, Jean-Yves Winum, Claudiu T. Supuran & Clemente Capasso. (2017) Anion inhibitors of the β-carbonic anhydrase from the pathogenic bacterium responsible of tularemia, Francisella tularensis. Bioorganic & Medicinal Chemistry 25:17, pages 4800-4804.
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Rosa Perfetto, Sonia Del Prete, Daniela Vullo, Giovanni Sansone, Carmela Barone, Mosè Rossi, Claudiu Supuran & Clemente Capasso. (2017) Sequence Analysis, Kinetic Constants, and Anion Inhibition Profile of the Nacrein-Like Protein (CgiNAP2X1) from the Pacific Oyster Magallana gigas (Ex-Crassostrea gigas). Marine Drugs 15:9, pages 270.
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Claudiu Supuran & Clemente Capasso. (2017) Carbonic Anhydrase from Porphyromonas Gingivalis as a Drug Target. Pathogens 6:3, pages 30.
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Sara Sanders, Ryan J. Vierling, David Bartee, Alicia A. DeColli, Mackenzie J. Harrison, Joseph L. Aklinski, Andrew T. Koppisch & Caren L. Freel Meyers. (2017) Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy- d -xylulose 5-Phosphate Synthase . ACS Infectious Diseases 3:7, pages 467-478.
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Sonia Del Prete, Daniela Vullo, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran & Clemente Capasso. (2017) Sulfonamide inhibition profiles of the β-carbonic anhydrase from the pathogenic bacterium Francisella tularensis responsible of the febrile illness tularemia. Bioorganic & Medicinal Chemistry 25:13, pages 3555-3561.
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Sonia Del Prete, Daniela Vullo, Didier Zoccola, Sylvie Tambutté, Clemente Capasso & Claudiu T. Supuran. (2017) Kinetic properties and affinities for sulfonamide inhibitors of an α-carbonic anhydrase (CruCA4) involved in coral biomineralization in the Mediterranean red coral Corallium rubrum. Bioorganic & Medicinal Chemistry 25:13, pages 3525-3530.
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Mina Ghiasi, Somaye Hemati & Mansour Zahedi. (2017) Activation modelling of β- and γ-class of carbonic anhydrase with amines and amino acids: Proton transfer process within the active site from thermodynamic point of view. Computational and Theoretical Chemistry 1109, pages 42-57.
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Fabrizio Carta, Daniela Vullo, Sameh M. Osman, Zeid AlOthman & Claudiu T. Supuran. (2017) Synthesis and carbonic anhydrase inhibition of a series of SLC-0111 analogs. Bioorganic & Medicinal Chemistry 25:9, pages 2569-2576.
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Menshawy A. Mohamed, Alaa A.-M. Abdel-Aziz, Helmy M. Sakr, Adel S. El-Azab, Silvia Bua & Claudiu T. Supuran. (2017) Synthesis and human/bacterial carbonic anhydrase inhibition with a series of sulfonamides incorporating phthalimido moieties. Bioorganic & Medicinal Chemistry 25:8, pages 2524-2529.
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Daniela Vullo, Sonia Del Prete, Pietro Di Fonzo, Vincenzo Carginale, W. Donald, Claudiu Supuran & Clemente Capasso. (2017) Comparison of the Sulfonamide Inhibition Profiles of the β- and γ-Carbonic Anhydrases from the Pathogenic Bacterium Burkholderia pseudomallei. Molecules 22:3, pages 421.
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Sonia Del Prete, Daniela Vullo, Pietro di Fonzo, Vincenzo Carginale, Claudiu T. Supuran & Clemente Capasso. (2017) Comparison of the anion inhibition profiles of the β- and γ-carbonic anhydrases from the pathogenic bacterium Burkholderia pseudomallei. Bioorganic & Medicinal Chemistry 25:6, pages 2010-2015.
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Sonia Del Prete, Daniela Vullo, Pietro Di Fonzo, Sameh M. Osman, Zeid AlOthman, William A. Donald, Claudiu T. Supuran & Clemente Capasso. (2017) Sulfonamide inhibition profile of the γ-carbonic anhydrase identified in the genome of the pathogenic bacterium Burkholderia pseudomallei the etiological agent responsible of melioidosis. Bioorganic & Medicinal Chemistry Letters 27:3, pages 490-495.
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Rajiv Kumar, Silvia Bua, Sita Ram, Sonia Del Prete, Clemente Capasso, Claudiu T. Supuran & Pawan K. Sharma. (2017) Benzenesulfonamide bearing imidazothiadiazole and thiazolotriazole scaffolds as potent tumor associated human carbonic anhydrase IX and XII inhibitors. Bioorganic & Medicinal Chemistry 25:3, pages 1286-1293.
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Daniela Vullo, Sonia Del Prete, Alessio Nocentini, Sameh M. Osman, Zeid AlOthman, Clemente Capasso, Murat Bozdag, Fabrizio Carta, Paola Gratteri & Claudiu T. Supuran. (2017) Dithiocarbamates effectively inhibit the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa. Bioorganic & Medicinal Chemistry 25:3, pages 1260-1265.
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Fevzi Topal, Ilhami Gulcin, Arif Dastan & Murat Guney. (2017) Novel eugenol derivatives: Potent acetylcholinesterase and carbonic anhydrase inhibitors. International Journal of Biological Macromolecules 94, pages 845-851.
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Srinivas Angapelly, P.V. Sri Ramya, Andrea Angeli, Simona Maria Monti, Martina Buonanno, Mallika Alvala, Cladiu T. Supuran & Mohammed Arifuddin. (2017) Discovery of 4-sulfamoyl-phenyl-β-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors. Bioorganic & Medicinal Chemistry 25:2, pages 539-544.
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Sonia Del Prete, Daniela Vullo, Pietro Di Fonzo, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran & Clemente Capasso. (2017) Anion inhibition profiles of the γ-carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei responsible of melioidosis and highly drug resistant to common antibiotics. Bioorganic & Medicinal Chemistry 25:2, pages 575-580.
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Sonia Del Prete, Daniela Vullo, Viviana De Luca, Vincenzo Carginale, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran & Clemente Capasso. (2016) Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum. Bioorganic & Medicinal Chemistry Letters 26:17, pages 4184-4190.
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Claudiu T. Supuran. (2016) Bortezomib inhibits bacterial and fungal β-carbonic anhydrases. Bioorganic & Medicinal Chemistry 24:18, pages 4406-4409.
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Sonia Del Prete, Daniela Vullo, Viviana De Luca, Vincenzo Carginale, Pietro di Fonzo, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran & Clemente Capasso. (2016) Anion inhibition profiles of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum. Bioorganic & Medicinal Chemistry 24:18, pages 4410-4414.
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Murat Bozdag, Ahmed M. Alafeefy, Fabrizio Carta, Mariangela Ceruso, Abdul-Malek S. Al-Tamimi, Abdulla A. Al-Kahtani, Fatmah A.S. Alasmary & Claudiu T. Supuran. (2016) Synthesis 4-[2-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-ethyl]-benzenesulfonamides with subnanomolar carbonic anhydrase II and XII inhibitory properties. Bioorganic & Medicinal Chemistry 24:18, pages 4100-4107.
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Alessio Nocentini, Daniela Vullo, Gianluca Bartolucci & Claudiu T. Supuran. (2016) N-Nitrosulfonamides: A new chemotype for carbonic anhydrase inhibition. Bioorganic & Medicinal Chemistry 24:16, pages 3612-3617.
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Sonia Del Prete, Daniela Vullo, Viviana De Luca, Vincenzo Carginale, Pietro di Fonzo, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran & Clemente Capasso. (2016) Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae. Bioorganic & Medicinal Chemistry 24:16, pages 3413-3417.
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Gitte M. Knudsen, Arvid Fromberg, Yin Ng & Lone Gram. (2016) Sublethal Concentrations of Antibiotics Cause Shift to Anaerobic Metabolism in Listeria monocytogenes and Induce Phenotypes Linked to Antibiotic Tolerance. Frontiers in Microbiology 7.
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Nagwa M. Abdel Gawad, Noha H. Amin, Mohammed T. Elsaadi, Fatma M.M. Mohamed, Andrea Angeli, Viviana De Luca, Clemente Capasso & Claudiu T. Supuran. (2016) Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines. Bioorganic & Medicinal Chemistry 24:13, pages 3043-3051.
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Satish Kumar, Mariangela Ceruso, Tiziano Tuccinardi, Claudiu T. Supuran & Pawan K. Sharma. (2016) Pyrazolylbenzo[ d ]imidazoles as new potent and selective inhibitors of carbonic anhydrase isoforms hCA IX and XII. Bioorganic & Medicinal Chemistry 24:13, pages 2907-2913.
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Daniela Vullo, Mariaconcetta Durante, Francesco Saverio Di Leva, Sandro Cosconati, Emanuela Masini, Andrea Scozzafava, Ettore Novellino, Claudiu T. Supuran & Fabrizio Carta. (2016) Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma. Journal of Medicinal Chemistry 59:12, pages 5857-5867.
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Claudiu Supuran. (2016) Legionella pneumophila Carbonic Anhydrases: Underexplored Antibacterial Drug Targets. Pathogens 5:2, pages 44.
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Tekin Artunç, Yasin Çetinkaya, Hülya Göçer, İlhami Gülçin, Abdullah Menzek, Ertan Şahin & Claudiu T. Supuran. (2016) Synthesis of 4-[2-(3,4-dimethoxybenzyl)cyclopentyl]-1,2-dimethoxybenzene Derivatives and Evaluations of Their Carbonic Anhydrase Isoenzymes Inhibitory Effects. Chemical Biology & Drug Design 87:4, pages 594-607.
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Sonia Del Prete, Daniela Vullo, Viviana De Luca, Vincenzo Carginale, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran & Clemente Capasso. (2016) Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae. Bioorganic & Medicinal Chemistry Letters 26:8, pages 1941-1946.
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Ayşenur Eminoğlu, Daniela Vullo, Aycan Aşık, Dilşat Nigar Çolak, Sabriye Çanakçı, Ali Osman Beldüz & Claudiu T. Supuran. (2016) Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13. Bioorganic & Medicinal Chemistry Letters 26:7, pages 1821-1826.
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Claudiu T Supuran. (2016) Inhibition of carbonic anhydrase from Trypanosoma cruzi for the management of Chagas disease: an underexplored therapeutic opportunity . Future Medicinal Chemistry 8:3, pages 311-324.
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Daniela Vullo, Sonia Del Prete, Clemente Capasso & Claudiu T. Supuran. (2016) Carbonic anhydrase activators: Activation of the β-carbonic anhydrase from Malassezia globosa with amines and amino acids. Bioorganic & Medicinal Chemistry Letters 26:5, pages 1381-1385.
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Daniela Vullo, Sonia Del Prete, Viviana De Luca, Vincenzo Carginale, Marta Ferraroni, Nurcan Dedeoglu, Sameh M. Osman, Zeid AlOthman, Clemente Capasso & Claudiu T. Supuran. (2016) Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae. Bioorganic & Medicinal Chemistry Letters 26:5, pages 1406-1410.
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Ahmed M. Alafeefy, Fabrizio Carta, Mariangela Ceruso, Abdul-Malek S. Al-Tamimi, Abdulla A. Al-Kahtani & Claudiu T. Supuran. (2016) Development of 3-(4-aminosulphonyl)-phenyl-2-mercapto-3H-quinazolin-4-ones as inhibitors of carbonic anhydrase isoforms involved in tumorigenesis and glaucoma. Bioorganic & Medicinal Chemistry 24:6, pages 1402-1407.
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Sonia Del Prete, Daniela Vullo, Viviana De Luca, Vincenzo Carginale, Marta Ferraroni, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran & Clemente Capasso. (2016) Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae. Bioorganic & Medicinal Chemistry 24:5, pages 1115-1120.
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Mustafa Durgun, Hasan Turkmen, Mariangela Ceruso & Claudiu T. Supuran. (2016) Synthesis of 4-sulfamoylphenyl-benzylamine derivatives with inhibitory activity against human carbonic anhydrase isoforms I, II, IX and XII. Bioorganic & Medicinal Chemistry 24:5, pages 982-988.
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Daniela Vullo, Viviana De Luca, Sonia Del Prete, Vincenzo Carginale, Andrea Scozzafava, Sameh M. Osman, Zeid AlOthman, Clemente Capasso & Claudiu T. Supuran. (2016) Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea. Bioorganic & Medicinal Chemistry Letters 26:4, pages 1253-1259.
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Elisabetta Barresi, Silvia Salerno, Anna Maria Marini, Sabrina Taliani, Concettina La Motta, Francesca Simorini, Federico Da Settimo, Daniela Vullo & Claudiu T. Supuran. (2016) Sulfonamides incorporating heteropolycyclic scaffolds show potent inhibitory action against carbonic anhydrase isoforms I, II, IX and XII. Bioorganic & Medicinal Chemistry 24:4, pages 921-927.
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Maria Luisa Villalba, Pablo Palestro, Mariangela Ceruso, Jose L. Gonzalez Funes, Alan Talevi, Luis Bruno Blanch, Claudiu T. Supuran & Luciana Gavernet. (2016) Sulfamide derivatives with selective carbonic anhydrase VII inhibitory action. Bioorganic & Medicinal Chemistry 24:4, pages 894-901.
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Viviana De Luca, Daniela Vullo, Sonia Del Prete, Vincenzo Carginale, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran & Clemente Capasso. (2016) Cloning, characterization and anion inhibition studies of a γ-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea. Bioorganic & Medicinal Chemistry 24:4, pages 835-840.
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