OncoImmunology, Volume 4, Issue 3 (2015)

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OncoImmunology, Volume 4, Issue 3 (2015)

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Author's View

Article
The ins and outs of osteopontin
Claudia Chiodoni, Sabina Sangaletti, Claudio Tripodo & Mario P Colombo
Article: e978711
Published online: 02 Apr 2015
AbstractforThe ins and outs of osteopontin | Full Text | References | PDF (152.7 KB)
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Article
Targeting tumor-associated myeloid cells for cancer immunotherapy
Hong Qin, Guowei Wei, Dongho Gwak, Zhenyuan Dong, Ailian Xiong & Larry W Kwak
Article: e983961
Published online: 02 Apr 2015
AbstractforTargeting tumor-associated myeloid cells for cancer immunotherapy | Full Text | References | PDF (214.4 KB)
  • 1226 Views
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Article
In situ immunization via non-surgical ablation to prevent local and distant tumor recurrence
Jesse J Veenstra, Heather M Gibson, Svend Freytag, Peter J Littrup & Wei-Zen Wei
Article: e989762
Published online: 02 Apr 2015
AbstractforIn situ immunization via non-surgical ablation to prevent local and distant tumor recurrence | Full Text | References | PDF (137.2 KB)
  • 887 Views
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Article
Serum HMGB1 is a predictive and prognostic biomarker for oncolytic immunotherapy
Ilkka Liikanen, Anniina Koski, Maiju Merisalo-Soikkeli, Otto Hemminki, Minna Oksanen, Kalevi Kairemo, Timo Joensuu, Anna Kanerva & Akseli Hemminki
Article: e989771
Published online: 02 Apr 2015
AbstractforSerum HMGB1 is a predictive and prognostic biomarker for oncolytic immunotherapy | Full Text | References | PDF (411.3 KB) | Supplemental
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Author's View - Commissioned

Article
miR-23a blockade enhances adoptive T cell transfer therapy by preserving immune-competence in the tumor microenvironment
Regina Lin, John H Sampson, Qi-Jing Li & Bo Zhu
Article: e990803
Published online: 02 Apr 2015
AbstractformiR-23a blockade enhances adoptive T cell transfer therapy by preserving immune-competence in the tumor microenvironment | Full Text | References | PDF (209 KB)
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Article
CD4+ T cell plasticity engenders robust immunity in response to cytokine therapy
Megan E Nelles & Christopher J Paige
Article: e994370
Published online: 16 Mar 2015
AbstractforCD4+ T cell plasticity engenders robust immunity in response to cytokine therapy | Full Text | References | PDF (172.6 KB)
  • 968 Views
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Article
Enhancing chemotherapy efficacy by reprogramming the senescence-associated secretory phenotype of prostate tumors
A way to reactivate the antitumor immunity
Alberto Toso, Diletta Di Mitri & Andrea Alimonti
Article: e994380
Published online: 20 Mar 2015
First Page PreviewforEnhancing chemotherapy efficacy by reprogramming the senescence-associated secretory phenotype of prostate tumors | Full Text | References | PDF (177.2 KB)
  • 1087 Views
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Article
Tregs activated by bispecific antibodies
Killers or suppressors?
Stefanie Koristka, Marc Cartellieri, Claudia Arndt, Anja Feldmann, Barbara Seliger, Gerhard Ehninger & Michael P. Bachmann
Article: e994441
Published online: 16 Mar 2015
AbstractforTregs activated by bispecific antibodies | Full Text | References | PDF (209.8 KB)
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Article
Controlling T cell senescence in the tumor microenvironment for tumor immunotherapy
Jian Ye & Guangyong Peng
Article: e994398
Published online: 16 Mar 2015
AbstractforControlling T cell senescence in the tumor microenvironment for tumor immunotherapy | Full Text | References | PDF (193.5 KB)
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Original Research

An immunogenomic stratification of colorectal cancer: Implications for development of targeted immunotherapy
Neeraj Lal, Andrew D Beggs, Benjamin E Willcox & Gary W Middleton
Article: e976052
Published online: 02 Apr 2015
AbstractforAn immunogenomic stratification of colorectal cancer: Implications for development of targeted immunotherapy | Full Text | References | PDF (711.5 KB) | Supplemental
  • 6805 Views
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Author's View

Article
Reducing toxicity of 4–1BB costimulation: targeting 4–1BB ligands to the tumor stroma with bi-specific aptamer conjugates
B Schrand, A Berezhnoy, R Brenneman, A Williams, A Levay & E Gilboa
Article: e970918
Published online: 23 Mar 2015
AbstractforReducing toxicity of 4–1BB costimulation: targeting 4–1BB ligands to the tumor stroma with bi-specific aptamer conjugates | Full Text | References | PDF (185.5 KB)
  • 1297 Views
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Original Research

Neutralization of membrane complement regulators improves complement-dependent effector functions of therapeutic anticancer antibodies targeting leukemic cells
Srinivas Mamidi, Simon Höne, Claudia Teufel, Leopold Sellner, Thorsten Zenz & Michael Kirschfink
Article: e979688
Published online: 02 Apr 2015
AbstractforNeutralization of membrane complement regulators improves complement-dependent effector functions of therapeutic anticancer antibodies targeting leukemic cells | Full Text | References | PDF (930.5 KB)
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Article
Targeting leukemia by CD1c-restricted T cells specific for a novel lipid antigen
Marco Lepore, Claudia de Lalla, Lucia Mori, Paolo Dellabona, Gennaro De Libero & Giulia Casorati
Article: e970463
Published online: 19 Mar 2015
AbstractforTargeting leukemia by CD1c-restricted T cells specific for a novel lipid antigen | Full Text | References | PDF (196.8 KB)
  • 900 Views
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Article
CTLs regulate tumor growth via cytostatic effects rather than cytotoxicity: a few T cells can influence the growth of many times more tumor cells
Kazuhiro Kakimi, Hirokazu Matsushita, Akihiro Hosoi, Manami Miyai & Osamu Ohara
Article: e970464
Published online: 19 Mar 2015
AbstractforCTLs regulate tumor growth via cytostatic effects rather than cytotoxicity: a few T cells can influence the growth of many times more tumor cells | Full Text | References | PDF (234.8 KB)
  • 1285 Views
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Article
Collaborative effects between the TNFα-TNFR1-macrophage axis and the VEGF-C-VEGFR3 signaling in lymphangiogenesis and metastasis
Renhai Cao, Hong Ji, Yunlong Yang & Yihai Cao
Article: e989777
Published online: 19 Mar 2015
AbstractforCollaborative effects between the TNFα-TNFR1-macrophage axis and the VEGF-C-VEGFR3 signaling in lymphangiogenesis and metastasis | Full Text | References | PDF (182.2 KB)
  • 864 Views
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Article
Dual roles of TLR7 in the lung cancer microenvironment
Marion Dajon, Kristina Iribarren & Isabelle Cremer
Article: e991615
Published online: 02 Apr 2015
AbstractforDual roles of TLR7 in the lung cancer microenvironment | Full Text | References | PDF (308.6 KB)
  • 1231 Views
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Article
Tumor immune remodeling by TGFβ inhibition improves the efficacy of radiation therapy
Kristina H Young, Michael J Gough & Marka Crittenden
Article: e955696
Published online: 02 Apr 2015
AbstractforTumor immune remodeling by TGFβ inhibition improves the efficacy of radiation therapy | Full Text | References | PDF (202 KB)
  • 775 Views
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Article
Author's view: radiation and immunotherapy as systemic therapy for solid tumors
Steven N. Seyedin, Chad Tang & James W Welsh
Article: e986402
Published online: 20 Mar 2015
AbstractforAuthor's view: radiation and immunotherapy as systemic therapy for solid tumors | Full Text | References | PDF (191.3 KB)
  • 978 Views
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Article
Situational aldehyde dehydrogenase expression by regulatory T cells may explain the contextual duality of cyclophosphamide as both a pro-inflammatory and tolerogenic agent
Christopher G Kanakry, Sudipto Ganguly & Leo Luznik
Article: e974393
Published online: 20 Mar 2015
AbstractforSituational aldehyde dehydrogenase expression by regulatory T cells may explain the contextual duality of cyclophosphamide as both a pro-inflammatory and tolerogenic agent | Full Text | References | PDF (116.5 KB)
  • 898 Views
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Article
Non-V delta 2 gamma delta T lymphocytes as effectors of cancer immunotherapy
Jonathan Fisher, Anne-Marijn Kramer, Kenth Gustafsson & John Anderson
Article: e973808
Published online: 20 Mar 2015
AbstractforNon-V delta 2 gamma delta T lymphocytes as effectors of cancer immunotherapy | Full Text | References | PDF (135.2 KB)
  • 2276 Views
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Original Research

Characterization of the in vivo immune network of IDO, tryptophan metabolism, PD-L1, and CTLA-4 in circulating immune cells in melanoma
I Chevolet, R Speeckaert, M Schreuer, B Neyns, O Krysko, C Bachert, B Hennart, D Allorge, N van Geel, M Van Gele & L Brochez
Article: e982382
Published online: 02 Apr 2015
AbstractforCharacterization of the in vivo immune network of IDO, tryptophan metabolism, PD-L1, and CTLA-4 in circulating immune cells in melanoma | Full Text | References | PDF (163.8 KB)
  • 3296 Views
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CD8+/FOXP3+-ratio in osteosarcoma microenvironment separates survivors from non-survivors: a multicenter validated retrospective study
Benedikt Fritzsching, Joerg Fellenberg, Linda Moskovszky, Zoltan Sápi, Tibor Krenacs, Isidro Machado, Johannes Poeschl, Burkhard Lehner, Miklos Szendrõi, Antonio Llombart Bosch, Ludger Bernd, Monika Csóka, Gunhild Mechtersheimer, Volker Ewerbeck, Ralf Kinscherf & Pierre Kunz
Article: e990800
Published online: 02 Apr 2015
AbstractforCD8+/FOXP3+-ratio in osteosarcoma microenvironment separates survivors from non-survivors: a multicenter validated retrospective study | Full Text | References | PDF (476.3 KB) | Supplemental
  • 2029 Views
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Ex vivo expanded human circulating Vδ1 γδT cells exhibit favorable therapeutic potential for colon cancer
Dang Wu, Pin Wu, Xianguo Wu, Jun Ye, Zhen Wang, Shuai Zhao, Chao Ni, Guoming Hu, Jinghong Xu, Yuehua Han, Ting Zhang, Fuming Qiu, Jun Yan & Jian Huang
Article: e992749
Published online: 02 Apr 2015
AbstractforEx vivo expanded human circulating Vδ1 γδT cells exhibit favorable therapeutic potential for colon cancer | Full Text | References | PDF (1.6 MB) | Supplemental
  • 4257 Views
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Kynurenine and uric acid levels in chronic myeloid leukemia patients
Vladimir Vonka, Zuzana Humlova, Hana Klamova, Lenka Kujovska-Krcmova, Martina Petrackova, Eva Hamsikova, Monika Krmencikova-Fliegl, Martina Duskova & Zdenek Roth
Article: e992646
Published online: 02 Apr 2015
AbstractforKynurenine and uric acid levels in chronic myeloid leukemia patients | Full Text | References | PDF (191.4 KB)
  • 1099 Views
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Novel role of hematopoietic stem cells in immunologic rejection of malignant gliomas
Catherine Flores, Christina Pham, David Snyder, Shicheng Yang, Luis Sanchez-Perez, Elias Sayour, Xiuyu Cui, Hanna Kemeny, Henry Friedman, Darell D Bigner, John Sampson & Duane A Mitchell
Article: e994374
Published online: 16 Mar 2015
AbstractforNovel role of hematopoietic stem cells in immunologic rejection of malignant gliomas | Full Text | References | PDF (587.2 KB) | Supplemental
  • 3037 Views
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Combating HER2-overexpressing breast cancer through induction of calreticulin exposure by Tras-Permut CrossMab
Fan Zhang, Jie Zhang, Moyan Liu, Lichao Zhao, RuiXia LingHu, Fan Feng, Xudong Gao, Shunchang Jiao, Lei Zhao, Yi Hu & Junlan Yang
Article: e994391
Published online: 20 Mar 2015
AbstractforCombating HER2-overexpressing breast cancer through induction of calreticulin exposure by Tras-Permut CrossMab | Full Text | References | PDF (1.3 MB) | Supplemental
  • 2083 Views
  • 16 CrossRef citations
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IL-12 secreting tumor-targeted chimeric antigen receptor T cells eradicate ovarian tumors in vivo
Mythili Koneru, Terence J. Purdon, David Spriggs, Susmith Koneru & Renier J. Brentjens
Article: e994446
Published online: 16 Mar 2015
AbstractforIL-12 secreting tumor-targeted chimeric antigen receptor T cells eradicate ovarian tumors in vivo | Full Text | References | PDF (673.4 KB)
  • 8746 Views
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Characterization of the myeloid-derived suppressor cell subset regulated by NK cells in malignant lymphoma
Yusuke Sato, Kanako Shimizu, Jun Shinga, Michihiro Hidaka, Fumio Kawano, Kazuhiro Kakimi, Satoru Yamasaki, Miki Asakura & Shin-ichiro Fujii
Article: e995541
Published online: 16 Mar 2015
AbstractforCharacterization of the myeloid-derived suppressor cell subset regulated by NK cells in malignant lymphoma | Full Text | References | PDF (850.1 KB) | Supplemental
  • 2295 Views
  • 35 CrossRef citations
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The combination of a novel immunomodulator with a regulatory T cell suppressing antibody (DTA-1) regress advanced stage B16F10 solid tumor by repolarizing tumor associated macrophages in situ
Sayantan Banerjee, Kuntal Halder, Sweta Ghosh, Anamika Bose & Subrata Majumdar
Article: e995559
Published online: 19 Mar 2015
AbstractforThe combination of a novel immunomodulator with a regulatory T cell suppressing antibody (DTA-1) regress advanced stage B16F10 solid tumor by repolarizing tumor associated macrophages in situ | Full Text | References | PDF (988.3 KB) | Supplemental
  • 1217 Views
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Natural killer T cell activation overcomes immunosuppression to enhance clearance of postsurgical breast cancer metastasis in mice
Simon Gebremeskel, Daniel R. Clattenburg, Drew Slauenwhite, Lynnea Lobert & Brent Johnston
Article: e995562
Published online: 19 Mar 2015
AbstractforNatural killer T cell activation overcomes immunosuppression to enhance clearance of postsurgical breast cancer metastasis in mice | Full Text | References | PDF (845 KB)
  • 3378 Views
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Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication
Oana Draghiciu, Hans W Nijman, Baukje Nynke Hoogeboom, Tjarko Meijerhof & Toos Daemen
Article: e989764
Published online: 02 Apr 2015
AbstractforSunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication | Full Text | References | PDF (529.3 KB) | Supplemental
  • 2613 Views
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Cancer stem cell vaccine inhibits metastases of primary tumors and induces humoral immune responses against cancer stem cells
Lin Lu, Huimin Tao, Alfred E Chang, Yangyang Hu, Guoshun Shu, Quanning Chen, Martin Egenti, John Owen, Jeffrey S Moyer, Mark EP Prince, Shiang Huang, Max S Wicha, Jian-Chuan Xia & Qiao Li
Article: e990767
Published online: 02 Apr 2015
AbstractforCancer stem cell vaccine inhibits metastases of primary tumors and induces humoral immune responses against cancer stem cells | Full Text | References | PDF (1.2 MB)
  • 2885 Views
  • 74 CrossRef citations
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Tumor-associated and immunochemotherapy-dependent long-term alterations of the peripheral blood NK cell compartment in DLBCL patients
M Christina Cox, Simone Battella, Raffaella La Scaleia, Sabrina Pelliccia, Arianna Di Napoli, Alessandra Porzia, Francesca Cecere, Eleonora Alma, Alessandra Zingoni, Fabrizio Mainiero, Luigi Ruco, Bruno Monarca, Angela Santoni & Gabriella Palmieri
Article: e990773
Published online: 02 Apr 2015
AbstractforTumor-associated and immunochemotherapy-dependent long-term alterations of the peripheral blood NK cell compartment in DLBCL patients | Full Text | References | PDF (829.1 KB) | Supplemental
  • 1442 Views
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NKT cell-targeted vaccination plus anti-4–1BB antibody generates persistent CD8 T cell immunity against B cell lymphoma
Takumi Kobayashi, Brianna L Doff, Rory C Rearden, Graham R Leggatt & Stephen R Mattarollo
Article: e990793
Published online: 02 Apr 2015
AbstractforNKT cell-targeted vaccination plus anti-4–1BB antibody generates persistent CD8 T cell immunity against B cell lymphoma | Full Text | References | PDF (752.3 KB) | Supplemental
  • 1978 Views
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Metabolic perturbation sensitizes human breast cancer to NK cell-mediated cytotoxicity by increasing the expression of MHC class I chain-related A/B
Dexue Fu, Jean-Francois Geschwind, Swathi Karthikeyan, Eliyahu Miller, Rani Kunjithapatham, Zhijun Wang & Shanmugasundaram Ganapathy-Kanniappan
Article: e991228
Published online: 02 Apr 2015
AbstractforMetabolic perturbation sensitizes human breast cancer to NK cell-mediated cytotoxicity by increasing the expression of MHC class I chain-related A/B | Full Text | References | PDF (1.2 MB)
  • 1238 Views
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Human NK cells activated by EBV+ lymphoblastoid cells overcome anti-apoptotic mechanisms of drug resistance in haematological cancer cells
Diego Sánchez-Martínez, Gemma Azaceta, Aura Muntasell, Nacho Aguiló, David Núñez, Eva M Gálvez, Javier Naval, Alberto Anel, Luis Palomera, Carlos Vilches, Isabel Marzo, Martín Villalba & Julián Pardo
Article: e991613
Published online: 02 Apr 2015
AbstractforHuman NK cells activated by EBV+ lymphoblastoid cells overcome anti-apoptotic mechanisms of drug resistance in haematological cancer cells | Full Text | References | PDF (760.8 KB) | Supplemental
  • 1484 Views
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High endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression
Diana Costa Bento, Emma Jones, Syed Junaid, Justyna Tull, Geraint T Williams, Andrew Godkin, Ann Ager & Awen Gallimore
Article: e974374
Published online: 02 Apr 2015
AbstractforHigh endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression | Full Text | References | PDF (591 KB) | Supplemental
  • 1583 Views
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Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against γδ T cell cytotoxicity
Daniel Gonnermann, Hans-Heinrich Oberg, Christian Kellner, Matthias Peipp, Susanne Sebens, Dieter Kabelitz & Daniela Wesch
Article: e988460
Published online: 20 Mar 2015
AbstractforResistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against γδ T cell cytotoxicity | Full Text | References | PDF (1.2 MB)
  • 1041 Views
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