Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 29, Issue 2 (2014)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 29, Issue 2 (2014)

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Research Article

Article
Evaluation of naproxen and cromolyn activities against cancer cells viability, proliferation, apoptosis, p53 and gene expression of survivin and caspase-3
Tarek M. K. Motawi, Yasser Bustanji, Shohda EL-Maraghy, Mutasem O. Taha & Mohamed A. S. Al-Ghussein
Pages: 153-161
Published online: 31 Jan 2013
AbstractforEvaluation of naproxen and cromolyn activities against cancer cells viability, proliferation, apoptosis, p53 and gene expression of survivin and caspase-3 | Full Text | References | PDF (1.3 MB)
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Original Article

Article
Cucurbitacins: potential candidates targeting mitogen-activated protein kinase pathway for treatment of melanoma
Mahmoud S. Ahmed & Fathi T. Halaweish
Pages: 162-167
Published online: 31 Jan 2013
AbstractforCucurbitacins: potential candidates targeting mitogen-activated protein kinase pathway for treatment of melanoma | Full Text | References | PDF (670.6 KB)
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Research Article

Article
Synthesis and carbonic anhydrase isoenzymes I and II inhibitory effects of novel benzylamine derivatives
Yasin Çetinkaya, Hülya Göçer, Süleyman Göksu & İlhami Gülçin
Pages: 168-174
Published online: 07 Feb 2013
AbstractforSynthesis and carbonic anhydrase isoenzymes I and II inhibitory effects of novel benzylamine derivatives | Full Text | References | PDF (236.8 KB)
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Article
Synthesis and anticancer activity evaluation of N-[4-(2-methylthiazol-4-yl)phenyl]acetamide derivatives containing (benz)azole moiety
Leyla Yurttaş, Yusuf Özkay, Gülşen Akalın-Çiftçi & Şafak Ulusoylar-Yıldırım
Pages: 175-184
Published online: 07 Feb 2013
AbstractforSynthesis and anticancer activity evaluation of N-[4-(2-methylthiazol-4-yl)phenyl]acetamide derivatives containing (benz)azole moiety | Full Text | References | PDF (815.9 KB)
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Original Article

Article
Antileishmanial activity evaluation of bis-lawsone analogs and DNA topoisomerase-I inhibition studies
Garima Sharma, Sayan Chowdhury, Suman Sinha, Hemanta K. Majumder & S. Vasanth Kumar
Pages: 185-189
Published online: 27 Mar 2013
AbstractforAntileishmanial activity evaluation of bis-lawsone analogs and DNA topoisomerase-I inhibition studies | Full Text | References | PDF (482.4 KB)
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Research Article

Article
Purification and identification of two antifungal cyclic dipeptides from Bacillus cereus subsp. thuringiensis associated with a rhabditid entomopathogenic nematode especially against Fusarium oxysporum
S. Nishanth Kumar, Bala Nambisan & C. Mohandas
Pages: 190-197
Published online: 13 Feb 2013
AbstractforPurification and identification of two antifungal cyclic dipeptides from Bacillus cereus subsp. thuringiensis associated with a rhabditid entomopathogenic nematode especially against Fusarium oxysporum | Full Text | References | PDF (707.3 KB)
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Article
New chemotypes as Trypanosoma cruzi triosephosphate isomerase inhibitors: a deeper insight into the mechanism of inhibition
Guzmán Alvarez, Jennyfer Martínez, Beatriz Aguirre-López, Nallely Cabrera, Leticia Pérez-Díaz, Marietta Tuena de Gómez-Puyou, Armando Gómez-Puyou, Ruy Pérez-Montfort, Beatriz Garat, Alicia Merlino, Mercedes González & Hugo Cerecetto
Pages: 198-204
Published online: 13 Feb 2013
AbstractforNew chemotypes as Trypanosoma cruzi triosephosphate isomerase inhibitors: a deeper insight into the mechanism of inhibition | Full Text | References | PDF (1.1 MB)
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Article
Synthesis and cytotoxicity studies of novel benzhydrylpiperazine carboxamide and thioamide derivatives
Enise Ece Gurdal, Irem Durmaz, Rengul Cetin-Atalay & Mine Yarim
Pages: 205-214
Published online: 08 Feb 2013
AbstractforSynthesis and cytotoxicity studies of novel benzhydrylpiperazine carboxamide and thioamide derivatives | Full Text | References | PDF (250 KB)
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Article
Discovery of new HER2/EGFR dual kinase inhibitors based on the anilinoquinazoline scaffold as potential anti-cancer agents
Maiada M. Sadek, Rabah A. Serrya, Abdel-Hamid N. Kafafy, Marawan Ahmed, Feng Wang & Khaled A. M. Abouzid
Pages: 215-222
Published online: 13 Feb 2013
AbstractforDiscovery of new HER2/EGFR dual kinase inhibitors based on the anilinoquinazoline scaffold as potential anti-cancer agents | Full Text | References | PDF (684.5 KB)
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Article
Cholesterol sulfate as a potential inhibitor of hepatitis C virus NS3 helicase
Atsushi Furuta, Kazi Abdus Salam, Nobuyoshi Akimitsu, Junichi Tanaka, Hidenori Tani, Atsuya Yamashita, Kohji Moriishi, Masamichi Nakakoshi, Masayoshi Tsubuki, Yuji Sekiguchi, Satoshi Tsuneda & Naohiro Noda
Pages: 223-229
Published online: 25 Feb 2013
AbstractforCholesterol sulfate as a potential inhibitor of hepatitis C virus NS3 helicase | Full Text | References | PDF (444.3 KB)
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Article
Sulfonamide–metal complexes endowed with potent anti-Trypanosoma cruzi activity
Zahid H. Chohan, Marcelo Zaldini Hernandes, Fabricio R. Sensato, Diogo Rodrigo Magalhaes Moreira, Valéria Rego Alves Pereira, Juliana Kelle de Andrade Lemoine Neves, Andresa Pereira de Oliveira, Beatriz Coutinho de Oliveira & Ana Cristina Lima Leite
Pages: 230-236
Published online: 25 Feb 2013
AbstractforSulfonamide–metal complexes endowed with potent anti-Trypanosoma cruzi activity | Full Text | References | PDF (1 MB)
  • 1008 Views
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Article
Synthesis and biological evaluation of novel antiviral agents as protein–protein interaction inhibitors
Stefania Ferro, Laura De Luca, Francesca Morreale, Frauke Christ, Zeger Debyser, Rosaria Gitto & Alba Chimirri
Pages: 237-242
Published online: 16 Jul 2013
AbstractforSynthesis and biological evaluation of novel antiviral agents as protein–protein interaction inhibitors | Full Text | References | PDF (491.1 KB)
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Article
Cytotoxicity and topoisomerase I/II inhibition activity of novel 4-aryl/alkyl-1-(piperidin-4-yl)-carbonylthiosemicarbazides and 4-benzoylthiosemicarbazides
Agata Siwek, Anna Bielawska, Elzbieta Maciorkowska, Monika Lepiarczyk, Krzysztof Bielawski, Nazar Trotsko & Monika Wujec
Pages: 243-248
Published online: 25 Feb 2013
AbstractforCytotoxicity and topoisomerase I/II inhibition activity of novel 4-aryl/alkyl-1-(piperidin-4-yl)-carbonylthiosemicarbazides and 4-benzoylthiosemicarbazides | Full Text | References | PDF (239.9 KB)
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Article
Synthesis and evaluation of 18F-labeled carbonic anhydrase IX inhibitors for imaging with positron emission tomography
Jinhe Pan, Joseph Lau, Felix Mesak, Navjit Hundal, Maral Pourghiasian, Zhibo Liu, François Bénard, Shoukat Dedhar, Claudiu T. Supuran & Kuo-Shyan Lin
Pages: 249-255
Published online: 07 Mar 2013
AbstractforSynthesis and evaluation of 18F-labeled carbonic anhydrase IX inhibitors for imaging with positron emission tomography | Full Text | References | PDF (969 KB)
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Article
Structural model of haptoglobin and its complex with the anticoagulant ecotin variants: structure–activity relationship study and analysis of interactions
Plínio Cunha Sathler, André Luiz Lourenço, Leonardo Alves Miceli, Carlos Rangel Rodrigues, Magaly Girão Albuquerque, Lúcio Mendes Cabral & Helena Carla Castro
Pages: 256-262
Published online: 12 Mar 2013
AbstractforStructural model of haptoglobin and its complex with the anticoagulant ecotin variants: structure–activity relationship study and analysis of interactions | Full Text | References | PDF (1.7 MB)
  • 777 Views
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Article
Imidazolylchromanones containing alkyl side chain as lanosterol 14α-demethylase inhibitors: synthesis, antifungal activity and docking study
Saeed Emami, Touba Banipoulad, Hamid Irannejad, Alireza Foroumadi, Mehraban Falahati, Mahtab Ashrafi-Khozani & Somaye Sharifynia
Pages: 263-271
Published online: 14 Mar 2013
AbstractforImidazolylchromanones containing alkyl side chain as lanosterol 14α-demethylase inhibitors: synthesis, antifungal activity and docking study | Full Text | References | PDF (1 MB)
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Article
Synthesis and evaluation of the anticonvulsant activity of 8-alkoxy-4,5-dihydrobenzo[b][1,2,4]triazolo[4,3-d][1,4]thiazepine derivatives
Xian-Qing Deng, Ming-Xia Song, Shi-Ben Wang & Zhe-Shan Quan
Pages: 272-280
Published online: 12 Mar 2013
AbstractforSynthesis and evaluation of the anticonvulsant activity of 8-alkoxy-4,5-dihydrobenzo[b][1,2,4]triazolo[4,3-d][1,4]thiazepine derivatives | Full Text | References | PDF (361.9 KB) | Supplemental
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Article
Synthesis and dual D2 and 5-HT1A receptor binding affinities of 5-piperidinyl and 5-piperazinyl-1H-benzo[d]imidazol-2(3H)-ones
Nisar Ullah
Pages: 281-291
Published online: 14 Mar 2013
AbstractforSynthesis and dual D2 and 5-HT1A receptor binding affinities of 5-piperidinyl and 5-piperazinyl-1H-benzo[d]imidazol-2(3H)-ones | Full Text | References | PDF (1.1 MB)
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Short Communication

Article
Novel coumarins and benzocoumarins acting as isoform-selective inhibitors against the tumor-associated carbonic anhydrase IX
Aditi Sharma, Meena Tiwari & Claudiu T. Supuran
Pages: 292-296
Published online: 14 Mar 2013
AbstractforNovel coumarins and benzocoumarins acting as isoform-selective inhibitors against the tumor-associated carbonic anhydrase IX | Full Text | References | PDF (180.5 KB)
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Original Article

Article
Effects of alpha lipoic acid and its R+ enantiomer supplemented to hyperbaric oxygen therapy on interleukin-6, TNF-α and EGF production in chronic leg wound healing
Emanuele Nasole, Cristian Nicoletti, Zhong-Jin Yang, Amelia Girelli, Alessandro Rubini, Francesca Giuffreda, Andrea Di Tano, Enrico Camporesi & Gerardo Bosco
Pages: 297-302
Published online: 30 Jan 2013
AbstractforEffects of alpha lipoic acid and its R+ enantiomer supplemented to hyperbaric oxygen therapy on interleukin-6, TNF-α and EGF production in chronic leg wound healing | Full Text | References | PDF (220.2 KB)
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