Journal of Extracellular Vesicles, Volume 5, Issue 1 (2016)

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Journal of Extracellular Vesicles, Volume 5, Issue 1 (2016)

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Invited Editorial

Editorial
The International Society for Extracellular Vesicles launches the first massive open online course on extracellular vesicles
Cecilia Lässer, Clotilde Théry, Edit I. Buzás, Suresh Mathivanan, Weian Zhao, Yong Song Gho & Jan Lötvall
Article: 34299
Published online: 16 Dec 2016
AbstractforThe International Society for Extracellular Vesicles launches the first massive open online course on extracellular vesicles | Full Text | References | PDF (309.1 KB)
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Review Articles

Review Article
Exosomal miRNAs as cancer biomarkers and therapeutic targets
Arron Thind & Clive Wilson
Article: 31292
Published online: 19 Jul 2016
AbstractforExosomal miRNAs as cancer biomarkers and therapeutic targets | Full Text | References | PDF (1.3 MB)
  • 5656 Views
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Original Research Articles

Article
High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources
Reka A. Haraszti, Marie-Cecile Didiot, Ellen Sapp, John Leszyk, Scott A. Shaffer, Hannah E. Rockwell, Fei Gao, Niven R. Narain, Marian DiFiglia, Michael A. Kiebish, Neil Aronin & Anastasia Khvorova
Article: 32570
Published online: 17 Nov 2016
AbstractforHigh-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources | Full Text | References | PDF (3.1 MB) | Supplemental
  • 13801 Views
  • 442 CrossRef citations
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Article
Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey
Chris Gardiner, Dolores Di Vizio, Susmita Sahoo, Clotilde Théry, Kenneth W. Witwer, Marca Wauben & Andrew F. Hill
Article: 32945
Published online: 31 Oct 2016
AbstractforTechniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey | Full Text | References | PDF (738.9 KB) | Supplemental
  • 14775 Views
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Article
Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin
Tania Martins-Marques, Maria Joao Pinho, Monica Zuzarte, Carla Oliveira, Paulo Pereira, Joost P. G. Sluijter, Celia Gomes & Henrique Girao
Article: 32538
Published online: 29 Sep 2016
AbstractforPresence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin | Full Text | References | PDF (2.6 MB) | Supplemental
  • 1882 Views
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Article
A standardized method to determine the concentration of extracellular vesicles using tunable resistive pulse sensing
Robert Vogel, Frank A. W. Coumans, Raluca G. Maltesen, Anita N. Böing, Katherine E. Bonnington, Marike L. Broekman, Murray F. Broom, Edit I. Buzás, Gunna Christiansen, Najat Hajji, Søren R. Kristensen, Meta J. Kuehn, Sigrid M. Lund, Sybren L. N. Maas, Rienk Nieuwland, Xabier Osteikoetxea, Rosalie Schnoor, Benjamin J. Scicluna, Mitch Shambrook, Jeroen de Vrij, Stephen I. Mann, Andrew F. Hill & Shona Pedersen
Article: 31242
Published online: 29 Sep 2016
AbstractforA standardized method to determine the concentration of extracellular vesicles using tunable resistive pulse sensing | Full Text | References | PDF (1.4 MB) | Supplemental
  • 5083 Views
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Article
Extracellular vesicles are present in mouse lymph and their level differs in atherosclerosis
Andreea Milasan, Nicolas Tessandier, Sisareuth Tan, Alain Brisson, Eric Boilard & Catherine Martel
Article: 31427
Published online: 22 Sep 2016
AbstractforExtracellular vesicles are present in mouse lymph and their level differs in atherosclerosis | Full Text | References | PDF (2.1 MB)
  • 1699 Views
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Article
miRNA profiling of circulating EpCAM+ extracellular vesicles: promising biomarkers of colorectal cancer
Marie Stampe Ostenfeld, Steffen Grann Jensen, Dennis Kjølhede Jeppesen, Lise-Lotte Christensen, Stine Buch Thorsen, Jan Stenvang, Michael Lykke Hvam, Anni Thomsen, Peter Mouritzen, Mads Heilskov Rasmussen, Hans Jørgen Nielsen, Torben Falck Ørntoft & Claus Lindbjerg Andersen
Article: 31488
Published online: 29 Aug 2016
AbstractformiRNA profiling of circulating EpCAM+ extracellular vesicles: promising biomarkers of colorectal cancer | Full Text | References | PDF (658.7 KB) | Supplemental
  • 2622 Views
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Article
Development of a rapid lateral flow immunoassay test for detection of exosomes previously enriched from cell culture medium and body fluids
Myriam Oliveira-Rodríguez, Sheila López-Cobo, Hugh T. Reyburn, Agustín Costa-García, Soraya López-Martín, María Yáñez-Mó, Eva Cernuda-Morollón, Annette Paschen, Mar Valés-Gómez & Maria Carmen Blanco-López
Article: 31803
Published online: 12 Aug 2016
AbstractforDevelopment of a rapid lateral flow immunoassay test for detection of exosomes previously enriched from cell culture medium and body fluids | Full Text | References | PDF (1.6 MB) | Supplemental
  • 5227 Views
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Article
Synovial fluid pretreatment with hyaluronidase facilitates isolation of CD44+ extracellular vesicles
Janneke Boere, Chris H. A. van de Lest, Sten F. W. M. Libregts, Ger J. A. Arkesteijn, Willie J. C. Geerts, Esther N. M. Nolte-'t Hoen, Jos Malda, P. René van Weeren & Marca H. M. Wauben
Article: 31751
Published online: 09 Aug 2016
AbstractforSynovial fluid pretreatment with hyaluronidase facilitates isolation of CD44+ extracellular vesicles | Full Text | References | PDF (2.6 MB) | Supplemental
  • 2214 Views
  • 21 CrossRef citations
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Article
Nanoparticle analysis sheds budding insights into genetic drivers of extracellular vesicle biogenesis
Stephanie N. Hurwitz, Meghan M. Conlon, Mark A. Rider, Naomi C. Brownstein & David G. Meckes Jr
Article: 31295
Published online: 13 Jul 2016
AbstractforNanoparticle analysis sheds budding insights into genetic drivers of extracellular vesicle biogenesis | Full Text | References | PDF (2.2 MB) | Supplemental
  • 3541 Views
  • 107 CrossRef citations
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Article
Plasmalogen enrichment in exosomes secreted by a nematode parasite versus those derived from its mouse host: implications for exosome stability and biology
Fabio Simbari, Jana McCaskill, Gillian Coakley, Marissa Millar, Rick M. Maizels, Gemma Fabriás, Josefina Casas & Amy H. Buck
Article: 30741
Published online: 05 Jul 2016
AbstractforPlasmalogen enrichment in exosomes secreted by a nematode parasite versus those derived from its mouse host: implications for exosome stability and biology | Full Text | References | PDF (1.6 MB) | Supplemental
  • 2241 Views
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Article
Proteomics analysis of vesicles isolated from plasma and urine of prostate cancer patients using a multiplex, aptamer-based protein array
Joanne Louise Welton, Paul Brennan, Mark Gurney, Jason Paul Webber, Lisa Kate Spary, David Gil Carton, Juan Manuel Falcón-Pérez, Sean Peter Walton, Malcolm David Mason, Zsuzsanna Tabi & Aled Clayton
Article: 31209
Published online: 29 Jun 2016
AbstractforProteomics analysis of vesicles isolated from plasma and urine of prostate cancer patients using a multiplex, aptamer-based protein array | Full Text | References | PDF (2.3 MB) | Supplemental
  • 3192 Views
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Article
Identification and characterization of EGF receptor in individual exosomes by fluorescence-activated vesicle sorting
James N. Higginbotham, Qin Zhang, Dennis K. Jeppesen, Andrew M. Scott, H. Charles Manning, Josiah Ochieng, Jeffrey L. Franklin & Robert J. Coffey
Article: 29254
Published online: 24 Jun 2016
AbstractforIdentification and characterization of EGF receptor in individual exosomes by fluorescence-activated vesicle sorting | Full Text | References | PDF (2 MB) | Supplemental
  • 4204 Views
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Article
Urinary extracellular vesicles for RNA extraction: optimization of a protocol devoid of prokaryote contamination
Dorota Tataruch-Weinert, Luca Musante, Oliver Kretz & Harry Holthofer
Article: 30281
Published online: 24 Jun 2016
AbstractforUrinary extracellular vesicles for RNA extraction: optimization of a protocol devoid of prokaryote contamination | Full Text | References | PDF (1.8 MB) | Supplemental
  • 2837 Views
  • 29 CrossRef citations
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Article
Isolation of human salivary extracellular vesicles by iodixanol density gradient ultracentrifugation and their characterizations
Kazuya Iwai, Tamiko Minamisawa, Kanako Suga, Yasutomo Yajima & Kiyotaka Shiba
Article: 30829
Published online: 17 May 2016
AbstractforIsolation of human salivary extracellular vesicles by iodixanol density gradient ultracentrifugation and their characterizations | Full Text | References | PDF (2 MB) | Supplemental
  • 4792 Views
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Article
A platform for actively loading cargo RNA to elucidate limiting steps in EV-mediated delivery
Michelle E. Hung & Joshua N. Leonard
Article: 31027
Published online: 13 May 2016
AbstractforA platform for actively loading cargo RNA to elucidate limiting steps in EV-mediated delivery | Full Text | References | PDF (659.9 KB) | Supplemental
  • 5438 Views
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Article
Characterization of procoagulant extracellular vesicles and platelet membrane disintegration in DMSO-cryopreserved platelets
Tseday Z. Tegegn, Silvia H. De Paoli, Martina Orecna, Oumsalama K. Elhelu, Samuel A. Woodle, Ivan D. Tarandovskiy, Mikhail V. Ovanesov & Jan Simak
Article: 30422
Published online: 04 May 2016
AbstractforCharacterization of procoagulant extracellular vesicles and platelet membrane disintegration in DMSO-cryopreserved platelets | Full Text | References | PDF (4 MB) | Supplemental
  • 2033 Views
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Article
Extensive surface protein profiles of extracellular vesicles from cancer cells may provide diagnostic signatures from blood samples
Larissa Belov, Kieran J. Matic, Susannah Hallal, O. Giles Best, Stephen P. Mulligan & Richard I. Christopherson
Article: 25355
Published online: 15 Apr 2016
AbstractforExtensive surface protein profiles of extracellular vesicles from cancer cells may provide diagnostic signatures from blood samples | Full Text | References | PDF (1.8 MB) | Supplemental
  • 3218 Views
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Article
Isolation of biologically active and morphologically intact exosomes from plasma of patients with cancer
Chang-Sook Hong, Sonja Funk, Laurent Muller, Michael Boyiadzis & Theresa L. Whiteside
Article: 29289
Published online: 24 Mar 2016
AbstractforIsolation of biologically active and morphologically intact exosomes from plasma of patients with cancer | Full Text | References | PDF (2.7 MB) | Supplemental
  • 7372 Views
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Article
Energy-requiring uptake of prostasomes and PC3 cell-derived exosomes into non-malignant and malignant cells
Karl Göran Ronquist, Claire Sanchez, Louise Dubois, Dimitris Chioureas, Pedro Fonseca, Anders Larsson, Anders Ullén, Jeffrey Yachnin, Gunnar Ronquist & Theocharis Panaretakis
Article: 29877
Published online: 07 Mar 2016
AbstractforEnergy-requiring uptake of prostasomes and PC3 cell-derived exosomes into non-malignant and malignant cells | Full Text | References | PDF (1.8 MB) | Supplemental
  • 1528 Views
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Article
MSC secretes at least 3 EV types each with a unique permutation of membrane lipid, protein and RNA
Ruenn Chai Lai, Soon Sim Tan, Ronne Wee Yeh Yeo, Andre Boon Hwa Choo, Agnes T. Reiner, Yan Su, Yang Shen, Zhiyan Fu, Lezhava Alexander, Siu Kwan Sze & Sai Kiang Lim
Article: 29828
Published online: 24 Feb 2016
AbstractforMSC secretes at least 3 EV types each with a unique permutation of membrane lipid, protein and RNA | Full Text | References | PDF (2.4 MB) | Supplemental
  • 4343 Views
  • 164 CrossRef citations
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Article
A novel multiplex bead-based platform highlights the diversity of extracellular vesicles
Nina Koliha, Yvonne Wiencek, Ute Heider, Christian Jüngst, Nikolay Kladt, Susanne Krauthäuser, Ian C. D. Johnston, Andreas Bosio, Astrid Schauss & Stefan Wild
Article: 29975
Published online: 19 Feb 2016
AbstractforA novel multiplex bead-based platform highlights the diversity of extracellular vesicles | Full Text | References | PDF (2 MB) | Supplemental
  • 5412 Views
  • 184 CrossRef citations
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Article
Different EV enrichment methods suitable for clinical settings yield different subpopulations of urinary extracellular vesicles from human samples
Felix Royo, Patricia Zuñiga-Garcia, Pilar Sanchez-Mosquera, Ainara Egia, Amparo Perez, Ana Loizaga, Raquel Arceo, Isabel Lacasa, Ainara Rabade, Edurne Arrieta, Roberto Bilbao, Miguel Unda, Arkaitz Carracedo & Juan M. Falcon-Perez
Article: 29497
Published online: 15 Feb 2016
AbstractforDifferent EV enrichment methods suitable for clinical settings yield different subpopulations of urinary extracellular vesicles from human samples | Full Text | References | PDF (1.7 MB) | Supplemental
  • 3216 Views
  • 99 CrossRef citations
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Article
Specific renal parenchymal-derived urinary extracellular vesicles identify age-associated structural changes in living donor kidneys
Anne E. Turco, Wing Lam, Andrew D. Rule, Aleksandar Denic, John C. Lieske, Virginia M. Miller, Joseph J. Larson, Walter K. Kremers & Muthuvel Jayachandran
Article: 29642
Published online: 01 Feb 2016
AbstractforSpecific renal parenchymal-derived urinary extracellular vesicles identify age-associated structural changes in living donor kidneys | Full Text | References | PDF (1.7 MB)
  • 1530 Views
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Short Communications

Brief Report
Display of GPI-anchored anti-EGFR nanobodies on extracellular vesicles promotes tumour cell targeting
Sander A. A. Kooijmans, Clara Gómez Aleza, Steve R. Roffler, Wouter W. van Solinge, Pieter Vader & Raymond M. Schiffelers
Article: 31053
Published online: 14 Mar 2016
AbstractforDisplay of GPI-anchored anti-EGFR nanobodies on extracellular vesicles promotes tumour cell targeting | Full Text | References | PDF (1.7 MB) | Supplemental
  • 5532 Views
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Letters to the Editors

Letter
Oncosomes – large and small: what are they, where they came from?
Brian Meehan, Janusz Rak & Dolores Di Vizio
Article: 33109
Published online: 27 Sep 2016
CitationforOncosomes – large and small: what are they, where they came from? | Full Text | References | PDF (270.7 KB)
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Technical Reports

Article
Comparative analysis of EV isolation procedures for miRNAs detection in serum samples
Zoraida Andreu, Eva Rivas, Aitana Sanguino-Pascual, Amalia Lamana, Mónica Marazuela, Isidoro González-Alvaro, Francisco Sánchez-Madrid, Hortensia de la Fuente & María Yáñez-Mó
Article: 31655
Published online: 20 Jun 2016
AbstractforComparative analysis of EV isolation procedures for miRNAs detection in serum samples | Full Text | References | PDF (1.8 MB)
  • 4381 Views
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Meeting Reports

Abstract
The 2nd United Kingdom Extracellular Vesicle Forum Meeting Abstracts
Article: 30924
Published online: 23 Feb 2016
First Page PreviewforThe 2nd United Kingdom Extracellular Vesicle Forum Meeting Abstracts | Full Text | PDF (612.6 KB)
  • 2398 Views
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Supplement 1, 2016

Abstract
The Fifth International Meeting of ISEV, ISEV2016, Rotterdam, The Netherlands, 4 – 7 May, 2016
Article: 31552
Published online: 30 May 2016
First Page PreviewforThe Fifth International Meeting of ISEV, ISEV2016, Rotterdam, The Netherlands, 4 – 7 May, 2016 | PDF (1.9 MB)
  • 2337 Views
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