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Review Article

An overview of the alpha-, beta- and gamma-carbonic anhydrases from Bacteria: can bacterial carbonic anhydrases shed new light on evolution of bacteria?

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Pages 325-332 | Received 17 Mar 2014, Accepted 27 Mar 2014, Published online: 25 Apr 2014

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Simone Giovannuzzi, Alessandro Bonardi, Paola Gratteri, Alessio Nocentini & Claudiu T. Supuran. (2023) Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Francesco Fiorentino, Alessio Nocentini, Dante Rotili, Claudiu T. Supuran & Antonello Mai. (2023) Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Susanna Haapanen, Andrea Angeli, Martti Tolvanen, Reza Zolfaghari Emameh, Claudiu T. Supuran & Seppo Parkkila. (2023) Cloning, characterization, and inhibition of the novel β-carbonic anhydrase from parasitic blood fluke, Schistosoma mansoni. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Simone Giovannuzzi, Viviana De Luca, Clemente Capasso & Claudiu T. Supuran. (2023) Inhibition studies with simple and complex (in)organic anions of the γ-carbonic anhydrase from Mammaliicoccus (Staphylococcus) sciuri, MscCAγ. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Andrea Angeli & Claudiu T. Supuran. (2023) Click chemistry approaches for developing carbonic anhydrase inhibitors and their applications. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Morteza Abdoli, Viviana De Luca, Clemente Capasso, Claudiu T. Supuran & Raivis Žalubovskis. (2023) Novel thiazolone-benzenesulphonamide inhibitors of human and bacterial carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Aiva Plotniece, Arkadij Sobolev, Claudiu T. Supuran, Fabrizio Carta, Fredrik Björkling, Henrik Franzyk, Jari Yli-Kauhaluoma, Koen Augustyns, Paul Cos, Linda De Vooght, Matthias Govaerts, Juliana Aizawa, Päivi Tammela & Raivis Žalubovskis. (2023) Selected strategies to fight pathogenic bacteria. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Maristela Barbosa Portela, Caroliny Mello Barboza, Eduardo Moreira da Silva, Daniel Clemente de Moraes, Renata Antoun Simão, Clara Ribeiro de Souza, Verônica da Silva Cardoso, Antônio Ferreira-Pereira, Alane Beatriz Vermelho & Claudiu T. Supuran. (2023) Dentine biomodification by sulphonamides pre-treatment: bond strength, proteolytic inhibition, and antimicrobial activity. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1, pages 319-329.
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Morteza Abdoli, Alessandro Bonardi, Claudiu T. Supuran & Raivis Žalubovskis. (2023) 4-Cyanamidobenzenesulfonamide derivatives: a novel class of human and bacterial carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1, pages 156-165.
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Claudiu T Supuran. (2023) An overview of novel antimicrobial carbonic anhydrase inhibitors. Expert Opinion on Therapeutic Targets 27:10, pages 897-910.
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Claudiu T Supuran. (2023) Targeting carbonic anhydrases for the management of hypoxic metastatic tumors. Expert Opinion on Therapeutic Patents 0:0, pages 1-20.
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Andrea Angeli, Linda J Urbański, Clemente Capasso, Seppo Parkkila & Claudiu T. Supuran. (2022) Activation studies with amino acids and amines of a β-carbonic anhydrase from Mammaliicoccus (Staphylococcus) sciuri previously annotated as Staphylococcus aureus (SauBCA) carbonic anhydrase. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2786-2792.
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Viviana De Luca, Vincenzo Carginale, Claudiu T. Supuran & Clemente Capasso. (2022) The gram-negative bacterium Escherichia coli as a model for testing the effect of carbonic anhydrase inhibition on bacterial growth. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2092-2098.
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Giulia Nannini, Viviana De Luca, Chiara D’Ambrosio, Andrea Scaloni, Antonio Taddei, Maria Novella Ringressi, Fabio Cianchi, Fabio Staderini, Clemente Capasso, Amedeo Amedei & Claudiu T. Supuran. (2022) A comparative study of carbonic anhydrase activity in lymphocytes from colorectal cancer tissues and adjacent healthy counterparts. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1651-1655.
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Simone Giovannuzzi, Chad S. Hewitt, Alessio Nocentini, Clemente Capasso, Daniel P. Flaherty & Claudiu T. Supuran. (2022) Coumarins effectively inhibit bacterial α-carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 333-338.
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Viviana De Luca, Andrea Angeli, Valeria Mazzone, Claudia Adelfio, Vincenzo Carginale, Andrea Scaloni, Fabrizio Carta, Silvia Selleri, Claudiu T. Supuran & Clemente Capasso. (2022) Heterologous expression and biochemical characterisation of the recombinant β-carbonic anhydrase (MpaCA) from the warm-blooded vertebrate pathogen malassezia pachydermatis. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 62-68.
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Nader S. Abutaleb, Ahmed E. M. Elhassanny, Alessio Nocentini, Chad S. Hewitt, Ahmed Elkashif, Bruce R. Cooper, Claudiu T. Supuran, Mohamed N. Seleem & Daniel P. Flaherty. (2022) Repurposing FDA-approved sulphonamide carbonic anhydrase inhibitors for treatment of Neisseria gonorrhoeae. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 51-61.
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Simone Giovannuzzi, Nader S. Abutaleb, Chad S. Hewitt, Fabrizio Carta, Alessio Nocentini, Mohamed N. Seleem, Daniel P. Flaherty & Claudiu T. Supuran. (2022) Dithiocarbamates effectively inhibit the α-carbonic anhydrase from Neisseria gonorrhoeae. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1-8.
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Alessio Nocentini, Claudiu T. Supuran & Clemente Capasso. (2021) An overview on the recently discovered iota-carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1988-1995.
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Linda J. Urbanski, Daniela Vullo, Seppo Parkkila & Claudiu T. Supuran. (2021) An anion and small molecule inhibition study of the β-carbonic anhydrase from Staphylococcus aureus. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1088-1092.
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Alessio Nocentini, Chad S. Hewitt, Margaret D. Mastrolorenzo, Daniel P. Flaherty & Claudiu T. Supuran. (2021) Anion inhibition studies of the α-carbonic anhydrases from Neisseria gonorrhoeae. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1061-1066.
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Viviana De Luca, Andrea Petreni, Vincenzo Carginale, Andrea Scaloni, Claudiu T. Supuran & Clemente Capasso. (2021) Effect of amino acids and amines on the activity of the recombinant ι-carbonic anhydrase from the Gram-negative bacterium Burkholderia territorii. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1000-1006.
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Alessio Nocentini, Andrea Angeli, Fabrizio Carta, Jean-Yves Winum, Raivis Zalubovskis, Simone Carradori, Clemente Capasso, William A. Donald & Claudiu T. Supuran. (2021) Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 561-580.
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Andrea Petreni, Viviana De Luca, Andrea Scaloni, Alessio Nocentini, Clemente Capasso & Claudiu T. Supuran. (2021) Anion inhibition studies of the Zn(II)-bound ι-carbonic anhydrase from the Gram-negative bacterium Burkholderia territorii. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 372-376.
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Claudiu T. Supuran & Clemente Capasso. (2020) Antibacterial carbonic anhydrase inhibitors: an update on the recent literature. Expert Opinion on Therapeutic Patents 30:12, pages 963-982.
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Claudiu T. Supuran. (2020) Exploring the multiple binding modes of inhibitors to carbonic anhydrases for novel drug discovery. Expert Opinion on Drug Discovery 15:6, pages 671-686.
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Claudiu T. Supuran. (2020) Coumarin carbonic anhydrase inhibitors from natural sources. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1462-1470.
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Alessio Nocentini, Sonia Del Prete, Margaret D. Mastrolorenzo, William A. Donald, Clemente Capasso & Claudiu T. Supuran. (2020) Activation studies of the β-carbonic anhydrases from Escherichia coli with amino acids and amines. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1379-1386.
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Patrizio Blandina, Gustavo Provensi, Maria Beatrice Passani, Clemente Capasso & Claudiu T. Supuran. (2020) Carbonic anhydrase modulation of emotional memory. Implications for the treatment of cognitive disorders. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1206-1214.
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Mehmet Oguz, Erbay Kalay, Suleyman Akocak, Alessio Nocentini, Nebih Lolak, Mehmet Boga, Mustafa Yilmaz & Claudiu T. Supuran. (2020) Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1215-1223.
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Sonia Del Prete, Alessio Nocentini, Claudiu T. Supuran & Clemente Capasso. (2020) Bacterial ι-carbonic anhydrase: a new active class of carbonic anhydrase identified in the genome of the Gram-negative bacterium Burkholderia territorii. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1060-1068.
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Aleksandrs Pustenko, Alessio Nocentini, Paola Gratteri, Alessandro Bonardi, Igor Vozny, Raivis Žalubovskis & Claudiu T. Supuran. (2020) The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1011-1020.
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Giovanna Salbitani, Sonia Del Prete, Francesco Bolinesi, Olga Mangoni, Viviana De Luca, Vincenzo Carginale, William A. Donald, Claudiu T. Supuran, Simona Carfagna & Clemente Capasso. (2020) Use of an immobilised thermostable α-CA (SspCA) for enhancing the metabolic efficiency of the freshwater green microalga Chlorella sorokiniana. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 913-920.
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Andrea Angeli, Sonia Del Prete, Cynthia Ghobril, Julien Hitce, Cécile Clavaud, Xavier Marrat, William A. Donald, Clemente Capasso & Claudiu T. Supuran. (2020) Activation studies of the β-carbonic anhydrases from Malassezia restricta with amines and amino acids. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 824-830.
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Aleksandrs Pustenko, Alessio Nocentini, Anastasija Balašova, Mikhail Krasavin, Raivis Žalubovskis & Claudiu T. Supuran. (2020) 7-Acylamino-3H-1,2-benzoxathiepine 2,2-dioxides as new isoform-selective carbonic anhydrase IX and XII inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 650-656.
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Rakia Abd Alhameed, Emanuela Berrino, Zainab Almarhoon, Ayman El-Faham & Claudiu T. Supuran. (2020) A class of carbonic anhydrase IX/XII – selective carboxylate inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 549-554.
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Ozen Ozensoy Guler, Claudiu. T. Supuran & Clemente Capasso. (2020) Carbonic anhydrase IX as a novel candidate in liquid biopsy. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 255-260.
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Mohamed A. Abdelrahman, Wagdy M. Eldehna, Alessio Nocentini, Hany S. Ibrahim, Hadia Almahli, Hatem A. Abdel-Aziz, Sahar M. Abou-Seri & Claudiu T. Supuran. (2020) Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 298-305.
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Suleyman Akocak & Claudiu T. Supuran. (2019) Activation of α-, β-, γ- δ-, ζ- and η- class of carbonic anhydrases with amines and amino acids: a review. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 1652-1659.
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Andrea Angeli, Sonia Del Prete, Mariana Pinteala, Stelian S. Maier, William A. Donald, Bogdan C. Simionescu, Clemente Capasso & Claudiu T. Supuran. (2019) The first activation study of the β-carbonic anhydrases from the pathogenic bacteria Brucella suis and Francisella tularensis with amines and amino acids. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 1178-1185.
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Pavitra S. Thacker, Pirpasha Shaikh, Andrea Angeli, Mohammed Arifuddin & Claudiu T. Supuran. (2019) Synthesis and biological evaluation of novel 8-substituted quinoline-2-carboxamides as carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 1172-1177.
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Alessio Nocentini, Sameh M. Osman, Igor A. Rodrigues, Veronica S. Cardoso, Fatmah Ali S. Alasmary, Zeid AlOthman, Alane B. Vermelho, Paola Gratteri & Claudiu T. Supuran. (2019) Appraisal of anti-protozoan activity of nitroaromatic benzenesulfonamides inhibiting carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 1164-1171.
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Andreza R. Garcia, Danielle M. P. Oliveira, Ana Claudia F. Amaral, Jéssica B. Jesus, Ana Carolina Rennó Sodero, Alessandra M. T. Souza, Claudiu T. Supuran, Alane B. Vermelho, Igor A. Rodrigues & Anderson S. Pinheiro. (2019) Leishmania infantum arginase: biochemical characterization and inhibition by naturally occurring phenolic substances. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 1100-1109.
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Sonia Del Prete, Rosa Merlo, Anna Valenti, Rosanna Mattossovich, Mosè Rossi, Vincenzo Carginale, Claudiu T. Supuran, Giuseppe Perugino & Clemente Capasso. (2019) Thermostability enhancement of the α-carbonic anhydrase from Sulfurihydrogenibium yellowstonense by using the anchoring-and-self-labelling-protein-tag system (ASL). Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 946-954.
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Atilla Akdemir, Andrea Angeli, Füsun Göktaş, Pınar Eraslan Elma, Nilgün Karalı & Claudiu T. Supuran. (2019) Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida β-carbonic anhydrase enzyme. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 528-531.
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Alessandra Rogato, Sonia Del Prete, Alessio Nocentini, Vincenzo Carginale, Claudiu T. Supuran & Clemente Capasso. (2019) Phaeodactylum tricornutum as a model organism for testing the membrane penetrability of sulphonamide carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 510-518.
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Yosselin Huentupil, Luis Peña, Néstor Novoa, Emanuela Berrino, Rodrigo Arancibia & Claudiu T. Supuran. (2019) New sulfonamides containing organometallic-acylhydrazones: synthesis, characterisation and biological evaluation as inhibitors of human carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 451-458.
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Maurizio Ronci, Sonia Del Prete, Valentina Puca, Simone Carradori, Vincenzo Carginale, Raffaella Muraro, Gabriella Mincione, Antonio Aceto, Francesca Sisto, Claudiu T. Supuran, Rossella Grande & Clemente Capasso. (2019) Identification and characterization of the α-CA in the outer membrane vesicles produced by Helicobacter pylori. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 189-195.
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Claudiu T. Supuran. (2018) Carbonic anhydrase inhibitors and their potential in a range of therapeutic areas. Expert Opinion on Therapeutic Patents 28:10, pages 709-712.
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Claudiu T. Supuran. (2018) Applications of carbonic anhydrases inhibitors in renal and central nervous system diseases. Expert Opinion on Therapeutic Patents 28:10, pages 713-721.
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Claudiu T. Supuran & Clemente Capasso. (2018) Biomedical applications of prokaryotic carbonic anhydrases. Expert Opinion on Therapeutic Patents 28:10, pages 745-754.
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Giannamaria Annunziato, Laura Giovati, Andrea Angeli, Marialaura Pavone, Sonia Del Prete, Marco Pieroni, Clemente Capasso, Agostino Bruno, Stefania Conti, Walter Magliani, Claudiu T. Supuran & Gabriele Costantino. (2018) Discovering a new class of antifungal agents that selectively inhibits microbial carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 1537-1544.
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Suleyman Akocak, Nabih Lolak, Silvia Bua & Claudiu T. Supuran. (2018) Discovery of novel 1,3-diaryltriazene sulfonamides as carbonic anhydrase I, II, VII, and IX inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 1575-1580.
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Mehdi Bouchouit, Sofiane Bouacida, Bachir Zouchoune, Hocine Merazig, Silvia Bua, Zouhair Bouaziz, Marc Le Borgne, Claudiu T. Supuran & Abdelmalek Bouraiou. (2018) Synthesis, X-ray structure, in silico calculation, and carbonic anhydrase inhibitory properties of benzylimidazole metal complexes. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 1150-1159.
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Marta Ferraroni, Roberto Gaspari, Andrea Scozzafava, Andrea Cavalli & Claudiu T. Supuran. (2018) Dioxygen, an unexpected carbonic anhydrase ligand. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 999-1005.
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Tanvi V. Wani, Silvia Bua, Pravin S. Khude, Abdul H. Chowdhary, Claudiu T. Supuran & Mrunmayee P. Toraskar. (2018) Evaluation of sulphonamide derivatives acting as inhibitors of human carbonic anhydrase isoforms I, II and Mycobacterium tuberculosis β-class enzyme Rv3273. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 962-971.
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Azzurra Stefanucci, Andrea Angeli, Marilisa Pia Dimmito, Grazia Luisi, Sonia Del Prete, Clemente Capasso, William A. Donald, Adriano Mollica & Claudiu T. Supuran. (2018) Activation of β- and γ-carbonic anhydrases from pathogenic bacteria with tripeptides. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 945-950.
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Verônica da Silva Cardoso, Alane Beatriz Vermelho, Eduardo Ricci Junior, Igor Almeida Rodrigues, Ana Maria Mazotto & Claudiu T. Supuran. (2018) Antileishmanial activity of sulphonamide nanoemulsions targeting the β-carbonic anhydrase from Leishmania species. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 850-857.
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Benoit Métayer, Andrea Angeli, Agnès Mingot, Kévin Jouvin, Gwilherm Evano, Claudiu T. Supuran & Sébastien Thibaudeau. (2018) Fluoroenesulphonamides: N-sulphonylurea isosteres showing nanomolar selective cancer-related transmembrane human carbonic anhydrase inhibition. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 804-808.
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Silvia Bua, Murat Bozdag, Sonia Del Prete, Fabrizio Carta, William A. Donald, Clemente Capasso & Claudiu T. Supuran. (2018) Mono- and di-thiocarbamate inhibition studies of the δ-carbonic anhydrase TweCAδ from the marine diatom Thalassiosira weissflogii. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 707-713.
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Andrea Angeli, Fatmah A. S. Alasmary, Sonia Del Prete, Sameh M. Osman, Zeid AlOthman, William A. Donald, Clemente Capasso & Claudiu T. Supuran. (2018) The first activation study of a δ-carbonic anhydrase: TweCAδ from the diatom Thalassiosira weissflogii is effectively activated by amines and amino acids. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 680-685.
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Claudiu T. Supuran. (2018) Carbon- versus sulphur-based zinc binding groups for carbonic anhydrase inhibitors?. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 485-495.
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Andrea Angeli, Sonia Del Prete, Sameh M. Osman, Fatmah A. S. Alasmary, Zeid AlOthman, William A. Donald, Clemente Capasso & Claudiu T. Supuran. (2018) Activation studies with amines and amino acids of the β-carbonic anhydrase encoded by the Rv3273 gene from the pathogenic bacterium Mycobacterium tuberculosis. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 364-369.
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Daniela Vullo, Leo Syrjänen, Marianne Kuuslahti, Seppo Parkkila & Claudiu T. Supuran. (2018) Anion inhibition studies of a beta carbonic anhydrase from the malaria mosquito Anopheles gambiae. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 359-363.
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Andrea Angeli, Sonia Del Prete, Sameh M. Osman, Fatmah A. S. Alasmary, Zeid AlOthman, William A. Donald, Clemente Capasso & Claudiu T. Supuran. (2018) Activation studies of the α- and β-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae with amines and amino acids. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 227-233.
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Alane Beatriz Vermelho, Verônica da Silva Cardoso, Eduardo Ricci Junior, Elisabete Pereira dos Santos & Claudiu T. Supuran. (2018) Nanoemulsions of sulfonamide carbonic anhydrase inhibitors strongly inhibit the growth of Trypanosoma cruzi. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 139-146.
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Daniela Vullo, R. Siva Sai Kumar, Andrea Scozzafava, James G. Ferry & Claudiu T. Supuran. (2018) Sulphonamide inhibition studies of the β-carbonic anhydrase from the bacterial pathogen Clostridium perfringens. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 31-36.
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Daniela Vullo, Sonia Del Prete, Sameh M. Osman, Fatmah A. S. Alasmary, Zeid AlOthman, William A. Donald, Clemente Capasso & Claudiu T. Supuran. (2018) Comparison of the amine/amino acid activation profiles of the β- and γ-carbonic anhydrases from the pathogenic bacterium Burkholderia pseudomallei. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 25-30.
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Claudiu T. Supuran. (2017) Advances in structure-based drug discovery of carbonic anhydrase inhibitors. Expert Opinion on Drug Discovery 12:1, pages 61-88.
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Suleyman Akocak, Nabih Lolak, Daniela Vullo, Mustafa Durgun & Claudiu T. Supuran. (2017) Synthesis and biological evaluation of histamine Schiff bases as carbonic anhydrase I, II, IV, VII, and IX activators. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 1305-1312.
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P. V. Sri Ramya, Srinivas Angapelly, Andrea Angeli, Chander Singh Digwal, Mohammed Arifuddin, Bathini Nagendra Babu, Claudiu T. Supuran & Ahmed Kamal. (2017) Discovery of curcumin inspired sulfonamide derivatives as a new class of carbonic anhydrase isoforms I, II, IX, and XII inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 1274-1281.
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Andrea Angeli, Fabio Vaiano, Francesco Mari, Elisabetta Bertol & Claudiu T. Supuran. (2017) Psychoactive substances belonging to the amphetamine class potently activate brain carbonic anhydrase isoforms VA, VB, VII, and XII. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 1253-1259.
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Morteza Abdoli, Andrea Angeli, Murat Bozdag, Fabrizio Carta, Ali Kakanejadifard, Hamid Saeidian & Claudiu T. Supuran. (2017) Synthesis and carbonic anhydrase I, II, VII, and IX inhibition studies with a series of benzo[d]thiazole-5- and 6-sulfonamides. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 1071-1078.
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Sonia Del Prete, Rosa Perfetto, Mosè Rossi, Fatmah A. S. Alasmary, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran & Clemente Capasso. (2017) A one-step procedure for immobilising the thermostable carbonic anhydrase (SspCA) on the surface membrane of Escherichia coli. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 1120-1128.
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Alessio Nocentini, Daniela Vullo, Sonia Del Prete, Sameh M. Osman, Fatmah A.S. Alasmary, Zeid AlOthman, Clemente Capasso, Fabrizio Carta, Paola Gratteri & Claudiu T. Supuran. (2017) Inhibition of the β-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa with monothiocarbamates. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 1064-1070.
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Rosa Perfetto, Sonia Del Prete, Daniela Vullo, Vincenzo Carginale, Giovanni Sansone, Carmela M. A. Barone, Mosè Rossi, Fatmah A. S. Alasmary, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran & Clemente Capasso. (2017) Cloning, expression and purification of the α-carbonic anhydrase from the mantle of the Mediterranean mussel, Mytilus galloprovincialis. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 1029-1035.
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Murat Bozdag, Silvia Bua, Sameh M. Osman, Zeid AlOthman & Claudiu T. Supuran. (2017) Carbonic anhydrase I, II, IV and IX inhibition with a series of 7-amino-3,4-dihydroquinolin-2(1H)-one derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 885-892.
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Daniela De Vita, Andrea Angeli, Fabiana Pandolfi, Martina Bortolami, Roberta Costi, Roberto Di Santo, Elisabetta Suffredini, Mariangela Ceruso, Sonia Del Prete, Clemente Capasso, Luigi Scipione & Claudiu T. Supuran. (2017) Inhibition of the α-carbonic anhydrase from Vibrio cholerae with amides and sulfonamides incorporating imidazole moieties. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 798-804.
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Rosa Perfetto, Sonia Del Prete, Daniela Vullo, Giovanni Sansone, Carmela M.A. Barone, Mosè Rossi, Claudiu T. Supuran & Clemente Capasso. (2017) Production and covalent immobilisation of the recombinant bacterial carbonic anhydrase (SspCA) onto magnetic nanoparticles. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 759-766.
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Marco Bragagni, Fabrizio Carta, Sameh M. Osman, Zeid AlOthman & Claudiu T. Supuran. (2017) Synthesis of an acridine orange sulfonamide derivative with potent carbonic anhydrase IX inhibitory action. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 701-706.
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Rosa Perfetto, Sonia Del Prete, Daniela Vullo, Giovanni Sansone, Carmela Barone, Mosè Rossi, Claudiu T. Supuran & Clemente Capasso. (2017) Biochemical characterization of the native α-carbonic anhydrase purified from the mantle of the Mediterranean mussel, Mytilus galloprovincialis. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 632-639.
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Yeganeh Entezari Heravi, Hassan Sereshti, Ali Akbar Saboury, Jahan Ghasemi, Marzieh Amirmostofian & Claudiu T. Supuran. (2017) 3D QSAR studies, pharmacophore modeling, and virtual screening of diarylpyrazole–benzenesulfonamide derivatives as a template to obtain new inhibitors, using human carbonic anhydrase II as a model protein. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 688-700.
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Erol Licsandru, Muhammet Tanc, Istvan Kocsis, Mihail Barboiu & Claudiu T. Supuran. (2017) A class of carbonic anhydrase I – selective activators. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 37-46.
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Sonia Del Prete, Viviana De Luca, Giuseppina De Simone, Claudiu T. Supuran & Clemente Capasso. (2016) Cloning, expression and purification of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup4, pages 54-59.
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Elif Unluer, Halise Inci Gul, Alkan Demirtas, Hiroshi Sakagami, Naoki Umemura, Muhammet Tanc, Cavit Kazaz & Claudiu T. Supuran. (2016) Synthesis and bioactivity studies of 1-aryl-3-(2-hydroxyethylthio)-1-propanones. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup3, pages 105-109.
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Fadime Özbey, Parham Taslimi, İlhami Gülçin, Ahmet Maraş, Süleyman Göksu & Claudiu T. Supuran. (2016) Synthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup2, pages 79-85.
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Ramazan Ulus, Muharrem Kaya, Damla Demir, Ekrem Tunca & Metin Bülbül. (2016) Three-component synthesis and carbonic anhydrase inhibitory properties of novel octahydroacridines incorporating sulfaguanidine scaffold. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup2, pages 63-69.
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Jorge R. A. Diaz, Martín Fernández Baldo, Gustavo Echeverría, Héctor Baldoni, Daniela Vullo, Delia B. Soria, Claudiu T. Supuran & Gerardo E. Camí. (2016) A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup2, pages 51-62.
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Burhanettin Turan, Kivilcim Şendil, Emin Şengül, Mehmet Serdar Gültekin, Parham Taslimi, İlhami Gulçin & Claudiu T. Supuran. (2016) The synthesis of some β-lactams and investigation of their metal-chelating activity, carbonic anhydrase and acetylcholinesterase inhibition profiles. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup1, pages 79-88.
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Halise Inci Gul, Zehra Yazici, Muhammet Tanc & Claudiu T. Supuran. (2016) Inhibitory effects of benzimidazole containing new phenolic Mannich bases on human carbonic anhydrase isoforms hCA I and II. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1540-1544.
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Süleyman Yılmaz, Yusuf Akbaba, Bünyamin Özgeriş, Leyla Polat Köse, Süleyman Göksu, İlhami Gülçin, Saleh H. Alwasel & Claudiu T. Supuran. (2016) Synthesis and inhibitory properties of some carbamates on carbonic anhydrase and acetylcholine esterase. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1484-1491.
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F. Zehra Küçükbay, Hasan Küçükbay, Muhammet Tanc & Claudiu T. Supuran. (2016) Synthesis and carbonic anhydrase I, II, IV and XII inhibitory properties of N-protected amino acid – sulfonamide conjugates. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1476-1483.
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Leyla Polat Kose, İlhami Gulcin, Alper Yıldırım, Ufuk Atmaca, Murat Çelik, Saleh H. Alwasel & Claudiu T. Supuran. (2016) The human carbonic anhydrase isoenzymes I and II inhibitory effects of some hydroperoxides, alcohols, and acetates. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1248-1253.
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F. Zehra Küçükbay, Nesrin Buğday, Hasan Küçükbay, Muhammet Tanc & Claudiu T. Supuran. (2016) Synthesis, characterization and carbonic anhydrase inhibitory activity of novel benzothiazole derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1221-1225.
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F. Zehra Küçükbay, Hasan Küçükbay, Muhammet Tanc & Claudiu T. Supuran. (2016) Synthesis and carbonic anhydrase inhibitory properties of amino acid – coumarin/quinolinone conjugates incorporating glycine, alanine and phenylalanine moieties. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1198-1202.
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Sonia Del Prete, Viviana De Luca, Daniela Vullo, Sameh M. Osman, Zeid AlOthman, Vincenzo Carginale, Claudiu T. Supuran & Clemente Capasso. (2016) A new procedure for the cloning, expression and purification of the β-carbonic anhydrase from the pathogenic yeast Malassezia globosa, an anti-dandruff drug target. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1156-1161.
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Furkan Orhan, Murat Şentürk & Claudiu T. Supuran. (2016) Interaction of anions with a newly characterized alpha carbonic anhydrase from Halomonas sp. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1119-1123.
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Ayşenur Eminoğlu, Daniela Vullo, Aycan Aşık, Dilşat Nigar Çolak, Claudiu T. Supuran, Sabriye Çanakçı & Ali Osman Beldüz. (2016) Cloning, expression and biochemical characterization of a β-carbonic anhydrase from the soil bacterium Enterobacter sp. B13. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1111-1118.
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Claudiu T. Supuran & Clemente Capasso. (2016) New light on bacterial carbonic anhydrases phylogeny based on the analysis of signal peptide sequences. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1254-1260.
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Claudiu T. Supuran. (2016) CA IX stratification based on cancer treatment: a patent evaluation of US2016/0002350. Expert Opinion on Therapeutic Patents 26:10, pages 1105-1109.
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Viviana De Luca, Sonia Del Prete, Daniela Vullo, Vincenzo Carginale, Pietro Di Fonzo, Sameh M Osman, Zeid AlOthman, Claudiu T Supuran & Clemente Capasso. (2016) Expression and characterization of a recombinant psychrophilic γ-carbonic anhydrase (NcoCA) identified in the genome of the Antarctic cyanobacteria belonging to the genus Nostoc. Journal of Enzyme Inhibition and Medicinal Chemistry 31:5, pages 810-817.
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György M. Buzás & Claudiu T. Supuran. (2016) The history and rationale of using carbonic anhydrase inhibitors in the treatment of peptic ulcers. In memoriam Ioan Puşcaş (1932–2015). Journal of Enzyme Inhibition and Medicinal Chemistry 31:4, pages 527-533.
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Claudiu T. Supuran. (2016) How many carbonic anhydrase inhibition mechanisms exist?. Journal of Enzyme Inhibition and Medicinal Chemistry 31:3, pages 345-360.
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Claudiu T. Supuran. (2016) Drug interaction considerations in the therapeutic use of carbonic anhydrase inhibitors. Expert Opinion on Drug Metabolism & Toxicology 12:4, pages 423-431.
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Sonia Del Prete, Viviana De Luca, Claudiu T. Supuran & Clemente Capasso. (2015) Protonography, a technique applicable for the analysis of η-carbonic anhydrase activity. Journal of Enzyme Inhibition and Medicinal Chemistry 30:6, pages 920-924.
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Joanna Ombouma, Daniela Vullo, Stephan Köhler, Pascal Dumy, Claudiu T. Supuran & Jean-Yves Winum. (2015) N-glycosyl-N-hydroxysulfamides as potent inhibitors of Brucella suis carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry 30:6, pages 1010-1012.
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Viviana De Luca, Sonia Del Prete, Vincenzo Carginale, Daniela Vullo, Claudiu T. Supuran & Clemente Capasso. (2015) A failed tentative to design a super carbonic anhydrase having the biochemical properties of the most thermostable CA (SspCA) and the fastest (SazCA) enzymes. Journal of Enzyme Inhibition and Medicinal Chemistry 30:6, pages 989-994.
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Claudiu T Supuran & Clemente Capasso. (2015) The η-class carbonic anhydrases as drug targets for antimalarial agents. Expert Opinion on Therapeutic Targets 19:4, pages 551-563.
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Viviana De Luca, Sonia Del Prete, Claudiu T. Supuran & Clemente Capasso. (2015) Protonography, a new technique for the analysis of carbonic anhydrase activity. Journal of Enzyme Inhibition and Medicinal Chemistry 30:2, pages 277-282.
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Articles from other publishers (206)

Claudiu T. Supuran. 2024. Metalloenzymes. Metalloenzymes 139 156 .
Divya Rai, Dulal Mondal & Srabani Taraphder. (2023) pH-Dependent Structure and Dynamics of the Catalytic Domains of Human Carbonic Anhydrase II and IX. The Journal of Physical Chemistry B 127:48, pages 10279-10294.
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Hui-Min Hao, Yan-Hui Bi, Ning-Ning Wei, Pei-Chong Lin, Shou-Hua Mei & Zhi-Gang Zhou. (2023) Expression of a periplasmic β-carbonic anhydrase (CA) gene is positively correlated with HCO3- utilization by the gametophytes of Saccharina japonica (Phaeophyceae, Ochrophyta). Journal of Applied Phycology 35:6, pages 3021-3040.
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Cansu Öztürk, Erbay Kalay, Serpil Gerni, Neslihan Balci, Feyzi Sinan Tokali, Osman Nuri Aslan & Emrah Polat. (2023) Sulfonamide derivatives with benzothiazole scaffold: Synthesis and carbonic anhydrase I–II inhibition properties. Biotechnology and Applied Biochemistry.
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Claudiu T. Supuran. (2023) Carbonic anhydrase versatility: from pH regulation to CO2 sensing and metabolism. Frontiers in Molecular Biosciences 10.
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Susanna Haapanen, Maarit S. Patrikainen & Seppo Parkkila. (2023) Ultrasensitive and rapid diagnostic tool for detection of Acanthamoeba castellanii. Diagnostic Microbiology and Infectious Disease 107:2, pages 116014.
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Suleyman Akocak, Nebih Lolak, Simone Giovannuzzi & Claudiu T. Supuran. (2023) Potent and selective carbonic anhydrase inhibition activities of pyrazolones bearing benzenesulfonamides. Bioorganic & Medicinal Chemistry Letters 95, pages 129479.
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Claudiu T. Supuran. (2023) A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation. Bioorganic & Medicinal Chemistry Letters 93, pages 129411.
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Anindita Hazarika & Meera Yadav. (2023) Biomineralization of carbon dioxide by carbonic anhydrase. Biocatalysis and Agricultural Biotechnology 51, pages 102755.
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Purnima Baidya, Bhim Kumar Dahal, Archana Pandit & Dev Raj Joshi. (2023) Bacteria-Induced Calcite Precipitation for Engineering and Environmental Applications. Advances in Materials Science and Engineering 2023, pages 1-25.
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Mohammad Sadegh Gheibzadeh, Colleen Varaidzo Manyumwa, Özlem Tastan Bishop, Hossein Shahbani Zahiri, Seppo Parkkila & Reza Zolfaghari Emameh. (2023) Genome Study of α-, β-, and γ-Carbonic Anhydrases from the Thermophilic Microbiome of Marine Hydrothermal Vent Ecosystems. Biology 12:6, pages 770.
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Zhaolong Nie, Kaihao Tang, Weiquan Wang, Pengxia Wang, Yunxue Guo, Yan Wang, Shuh-Ji Kao, Jianping Yin & Xiaoxue Wang. (2023) Comparative genomic insights into habitat adaptation of coral-associated Prosthecochloris. Frontiers in Microbiology 14.
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Clemente Capasso. (2023) Carbonic Anhydrases: A Superfamily of Ubiquitous Enzymes. International Journal of Molecular Sciences 24:8, pages 7014.
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Anil Kumar Marapaka, Alessio Nocentini, Molly S. Youse, Weiwei An, Katrina J. Holly, Chittaranjan Das, Ravi Yadav, Mohamed N. Seleem, Claudiu T. Supuran & Daniel P. Flaherty. (2022) Structural Characterization of Thiadiazolesulfonamide Inhibitors Bound to Neisseria gonorrhoeae α-Carbonic Anhydrase . ACS Medicinal Chemistry Letters 14:1, pages 103-109.
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Alessio Nocentini, Clemente Capasso & Claudiu T. Supuran. (2023) Carbonic Anhydrase Inhibitors as Novel Antibacterials in the Era of Antibiotic Resistance: Where Are We Now?. Antibiotics 12:1, pages 142.
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M. F. Ali, H. Mukhtar & L. Dufossé. (2022) Microbial calcite induction: a magic that fortifies and heals concrete. International Journal of Environmental Science and Technology 20:1, pages 1113-1134.
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Yanyou Wu & Sen RaoYanyou Wu & Sen Rao. 2023. Root-Derived Bicarbonate Assimilation in Plants. Root-Derived Bicarbonate Assimilation in Plants 55 95 .
Alessandro Bonardi, Claudiu T. Supuran & Alessio Nocentini. 2022. Flavonoids and Phenolics. Flavonoids and Phenolics 330 383 .
Claudiu T. Supuran. 2022. Flavonoids and Phenolics. Flavonoids and Phenolics 298 329 .
Claudiu T. Supuran. (2022) Carbonic Anhydrase Inhibitors from Marine Natural Products. Marine Drugs 20:11, pages 721.
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Viviana De Luca, Simone Giovannuzzi, Claudiu T. Supuran & Clemente Capasso. (2022) May Sulfonamide Inhibitors of Carbonic Anhydrases from Mammaliicoccus sciuri Prevent Antimicrobial Resistance Due to Gene Transfer to Other Harmful Staphylococci?. International Journal of Molecular Sciences 23:22, pages 13827.
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Daniel Barón Díaz, Anke Neumann & Habibu Aliyu. (2022) Thermophilic Water Gas Shift Reaction at High Carbon Monoxide and Hydrogen Partial Pressures in Parageobacillus thermoglucosidasius KP1013. Fermentation 8:11, pages 596.
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Zeynep Demirsoy & Gulcihan Gulseren. (2022) Self-Assembled Fullerene Nanostructures for Mimicking and Understanding of Natural Enzymes. ACS Applied Nano Materials 5:10, pages 14285-14295.
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Divya Rai, Satyajit Khatua & Srabani Taraphder. (2022) Structure and Dynamics of the Isozymes II and IX of Human Carbonic Anhydrase. ACS Omega 7:35, pages 31149-31166.
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Naying Chu, Yitong Wang, Hao Jia, Jie Han, Xiaoyi Wang & Zhuang Hou. (2022) Design, Synthesis and Biological Evaluation of New Carbohydrate-Based Coumarin Derivatives as Selective Carbonic Anhydrase IX Inhibitors via “Click” Reaction. Molecules 27:17, pages 5464.
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Xiaoyi Ma, Le Liu & Kai Tang. (2022) Carbon Dioxide Sequestration by Microbial Carbonic Anhydrases From Submarine Hydrothermal Systems. Frontiers in Marine Science 9.
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Neha Maheshwari, Indu Shekhar Thakur & Shaili Srivastava. (2022) Role of carbon-dioxide sequestering bacteria for clean air environment and prospective production of biomaterials: a sustainable approach. Environmental Science and Pollution Research 29:26, pages 38950-38971.
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Furkan Orhan, Murat Senturk & Mucip Genisel. (2022) A new carbonic anhydrase identified in the Gram-negative bacterium (Chromohalobacter sp.) and the interaction of anions with the enzyme. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 254, pages 109290.
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Priti Singh, Dilep Kumar Sigalapalli, Nerella Sridhar Goud, Baijayantimala Swain, Santosh Kumar Sahoo, Andrea Angeli, Afzal B. Shaik, Venkata Madhavi Yaddanapudi, Claudiu T. Supuran & Mohammed Arifuddin. (2021) Ureidosulfocoumarin Derivatives As Selective and Potent Carbonic Anhydrase IX and XII Inhibitors. ChemMedChem 17:5.
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Shijuan Wu, Zijie Zhou, Lin Zhu, Limin Zhong, Yixuan Dong, Gejiao Wang & Kaixiang Shi. (2022) Cd immobilization mechanisms in a Pseudomonas strain and its application in soil Cd remediation. Journal of Hazardous Materials 425, pages 127919.
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Laila Rubab, Sumbal Afroz, Sajjad Ahmad, Saddam Hussain, Iram Nawaz, Ali Irfan, Fozia Batool, Katarzyna Kotwica-Mojzych & Mariusz Mojzych. (2022) An Update on Synthesis of Coumarin Sulfonamides as Enzyme Inhibitors and Anticancer Agents. Molecules 27:5, pages 1604.
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Franziska Steger, Johanna Reich, Werner Fuchs, Simon K.-M. R. Rittmann, Georg M. Gübitz, Doris Ribitsch & Günther Bochmann. (2022) Comparison of Carbonic Anhydrases for CO2 Sequestration. International Journal of Molecular Sciences 23:2, pages 957.
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Anna Di Fiore, Viviana De Luca, Emma Langella, Alessio Nocentini, Martina Buonanno, Simona Maria Monti, Claudiu T. Supuran, Clemente Capasso & Giuseppina De Simone. (2022) Biochemical, structural, and computational studies of a γ-carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei. Computational and Structural Biotechnology Journal 20, pages 4185-4194.
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Alane Beatriz Vermelho, Verônica Cardoso, Felipe Raposo Passos Mansoldo, Claudiu T. Supuran, Sabrina Martins Lage Cedrola, Igor Almeida Rodrigues & Giseli Capaci Rodrigues. 2022. Antiprotozoal Drug Development and Delivery. Antiprotozoal Drug Development and Delivery 49 81 .
Julia Vincent, Béatrice Colin, Isabelle Lanneluc, René Sabot, Valérie Sopéna, Philippe Turcry, Pierre-Yves Mahieux, Philippe Refait, Marc Jeannin & Sophie Sablé. (2021) New Biocalcifying Marine Bacterial Strains Isolated from Calcareous Deposits and Immediate Surroundings. Microorganisms 10:1, pages 76.
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Eva Havránková, Vladimír Garaj, Šárka Mascaretti, Andrea Angeli, Zuzana Soldánová, Miroslav Kemka, Jozef Motyčka, Marie Brázdová, Jozef Csöllei, Josef Jampílek & Claudiu T. Supuran. (2021) Novel 1,3,5-Triazinyl Aminobenzenesulfonamides Incorporating Aminoalcohol, Aminochalcone and Aminostilbene Structural Motifs as Potent Anti-VRE Agents, and Carbonic Anhydrases I, II, VII, IX, and XII Inhibitors. International Journal of Molecular Sciences 23:1, pages 231.
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Sook-Ha Fan, Elisa Liberini & Friedrich Götz. (2021) Staphylococcus aureus Genomes Harbor Only MpsAB-Like Bicarbonate Transporter but Not Carbonic Anhydrase as Dissolved Inorganic Carbon Supply System. Microbiology Spectrum 9:3.
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Francesca Mancuso, Laura De Luca, Federica Bucolo, Milan Vrabel, Andrea Angeli, Clemente Capasso, Claudiu T. Supuran & Rosaria Gitto. (2021) 4‐Sulfamoylphenylalkylamides as Inhibitors of Carbonic Anhydrases Expressed in Vibrio cholerae . ChemMedChem 16:24, pages 3787-3794.
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Xin Wang, Yan-lian Feng, Xiao-yu Zhao, Ran An, Chun Cao, Meng-bi Guo, Rui Zhang, Yuan-xin Wang, Zhuang Hou & Chun Guo. (2021) Discovery of novel aminosaccharide-based sulfonamide derivatives as potential carbonic anhydrase II inhibitors. Bioorganic & Medicinal Chemistry Letters 53, pages 128420.
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Sigrid Görgen, Karim Benzerara, Fériel Skouri-Panet, Muriel Gugger, Franck Chauvat & Corinne Cassier-Chauvat. (2020) The diversity of molecular mechanisms of carbonate biomineralization by bacteria. Discover Materials 1:1.
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Viviana De Luca, Andrea Angeli, Valeria Mazzone, Claudia Adelfio, Fabrizio Carta, Silvia Selleri, Vincenzo Carginale, Andrea Scaloni, Claudiu T. Supuran & Clemente Capasso. (2021) Inhibitory Effects of Sulfonamide Derivatives on the β-Carbonic Anhydrase (MpaCA) from Malassezia pachydermatis, a Commensal, Pathogenic Fungus Present in Domestic Animals. International Journal of Molecular Sciences 22:22, pages 12601.
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Andrea Angeli, Victor Kartsev, Anthi Petrou, Mariana Pinteala, Volodymyr Brovarets, Roman Vydzhak, Svitlana Panchishin, Athina Geronikaki & Claudiu T. Supuran. (2021) Carbonic Anhydrase Inhibition with Sulfonamides Incorporating Pyrazole- and Pyridazinecarboxamide Moieties Provides Examples of Isoform-Selective Inhibitors. Molecules 26:22, pages 7023.
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Shizheng Xiang, Yiqiang Li, Wanying Wang, Biao Zhang, Wenyu Shi, Jia Zhang, Fuyang Huang, Fei Liu & Xiangyu Guan. (2021) Antibiotics adaptation costs alter carbon sequestration strategies of microorganisms in karst river. Environmental Pollution 288, pages 117819.
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Hongyan Chuai, San-Qi Zhang, Huanrong Bai, Jiyu Li, Yang Wang, Jiajia Sun, Ergang Wen, Jiye Zhang & Minhang Xin. (2021) Small molecule selenium-containing compounds: Recent development and therapeutic applications. European Journal of Medicinal Chemistry 223, pages 113621.
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Nurdan Gönül Baltacı, Enver Fehim Koçpınar & Harun Budak. (2021) Tip60 might be a candidate for the acetylation of hepatic carbonic anhydrase I and III in mice. Molecular Biology Reports 48:11, pages 7397-7404.
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Rossella Grande, Simone Carradori, Valentina Puca, Irene Vitale, Andrea Angeli, Alessio Nocentini, Alessandro Bonardi, Paola Gratteri, Paola Lanuti, Giuseppina Bologna, Pasquale Simeone, Clemente Capasso, Viviana De Luca & Claudiu T. Supuran. (2021) Selective Inhibition of Helicobacter pylori Carbonic Anhydrases by Carvacrol and Thymol Could Impair Biofilm Production and the Release of Outer Membrane Vesicles. International Journal of Molecular Sciences 22:21, pages 11583.
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Andrea Angeli, Victor Kartsev, Anthi Petrou, Mariana Pinteala, Roman M. Vydzhak, Svitlana Y. Panchishin, Volodymyr Brovarets, Viviana De Luca, Clemente Capasso, Athina Geronikaki & Claudiu T. Supuran. (2021) New Sulfanilamide Derivatives Incorporating Heterocyclic Carboxamide Moieties as Carbonic Anhydrase Inhibitors. Pharmaceuticals 14:8, pages 828.
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Ethan Hain, Hollie Adejumo, Bridget Anger, Joseph Orenstein & Lee Blaney. (2021) Advances in antimicrobial activity analysis of fluoroquinolone, macrolide, sulfonamide, and tetracycline antibiotics for environmental applications through improved bacteria selection. Journal of Hazardous Materials 415, pages 125686.
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Ali Irfan, Sajjad Ahmad, Saddam Hussain, Fozia Batool, Haseeba Riaz, Rehman Zafar, Katarzyna Kotwica-Mojzych & Mariusz Mojzych. (2021) Recent Updates on the Synthesis of Bioactive Quinoxaline-Containing Sulfonamides. Applied Sciences 11:12, pages 5702.
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Claudiu T. Supuran. (2021) Emerging role of carbonic anhydrase inhibitors. Clinical Science 135:10, pages 1233-1249.
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Ayşe Hümeyra TAŞKIN KAFA, Arzu CİHAN, Mehmet KUZUCU & Murat ÇANKAYA. (2021) Cloning, Over-Expression, and Purification of β–Carbonic Anhydrase from an Extremophilic Bacterium: Deinococcus radioduransEkstremofilik bir bakteri olan Deinococcus radiodurans’dan β–Karbonik Anhidraz’ın klonlanması, Aşırı İfadesi ve Saflaştırılması. Hacettepe Journal of Biology and Chemistry 49:3, pages 219-231.
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Md. Rajib Sharker, Zahid Parvez Sukhan, Kanij Rukshana Sumi, Sang Ki Choi, Kap Seong Choi & Kang Hee Kho. (2021) Molecular Characterization of Carbonic Anhydrase II (CA II) and Its Potential Involvement in Regulating Shell Formation in the Pacific Abalone, Haliotis discus hannai. Frontiers in Molecular Biosciences 8.
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Claudiu T. Supuran & Clemente Capasso. (2021) A Highlight on the Inhibition of Fungal Carbonic Anhydrases as Drug Targets for the Antifungal Armamentarium. International Journal of Molecular Sciences 22:9, pages 4324.
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Shashi Kumar & Parag A. Deshpande. (2021) Structural and thermodynamic analysis of factors governing the stability and thermal folding/unfolding of SazCA. PLOS ONE 16:4, pages e0249866.
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Manju Verma, Gaurav A. Bhaduri, V. Sai Phani Kumar & Parag A. Deshpande. (2021) Biomimetic Catalysis of CO 2 Hydration: A Materials Perspective . Industrial & Engineering Chemistry Research 60:13, pages 4777-4793.
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Nader S. Abutaleb, Ahmed E.M. Elhassanny, Daniel P. Flaherty & Mohamed N. Seleem. (2021) In vitro and in vivo activities of the carbonic anhydrase inhibitor, dorzolamide, against vancomycin-resistant enterococci. PeerJ 9, pages e11059.
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Cristina Campestre, Viviana De Luca, Simone Carradori, Rossella Grande, Vincenzo Carginale, Andrea Scaloni, Claudiu T. Supuran & Clemente Capasso. (2021) Carbonic Anhydrases: New Perspectives on Protein Functional Role and Inhibition in Helicobacter pylori. Frontiers in Microbiology 12.
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Erik Borchert, Antonio García-Moyano, Sergio Sanchez-Carrillo, Thomas G. Dahlgren, Beate M. Slaby, Gro Elin Kjæreng Bjerga, Manuel Ferrer, Sören Franzenburg & Ute Hentschel. (2021) Deciphering a Marine Bone-Degrading Microbiome Reveals a Complex Community Effort. mSystems 6:1.
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Viviana De Luca, Andrea Petreni, Alessio Nocentini, Andrea Scaloni, Claudiu T. Supuran & Clemente Capasso. (2021) Effect of Sulfonamides and Their Structurally Related Derivatives on the Activity of ι-Carbonic Anhydrase from Burkholderia territorii. International Journal of Molecular Sciences 22:2, pages 571.
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Emily A. Kraus, Daniel Nothaft, Blake W. Stamps, Kaitlin R. Rempfert, Eric T. Ellison, Juerg M. Matter, Alexis S. Templeton, Eric S. Boyd & John R. Spear. (2021) Molecular Evidence for an Active Microbial Methane Cycle in Subsurface Serpentinite-Hosted Groundwaters in the Samail Ophiolite, Oman. Applied and Environmental Microbiology 87:2.
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Shubham Kumar, Sandeep Rulhania, Shalini Jaswal & Vikramdeep Monga. (2021) Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors. European Journal of Medicinal Chemistry 209, pages 112923.
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Claudiu T. Supuran. 2021. The Carbonic Anhydrases: Current and Emerging Therapeutic Targets. The Carbonic Anhydrases: Current and Emerging Therapeutic Targets 221 235 .
Alessio Nocentini, Alane B. Vermelho & Claudiu T. Supuran. 2022. Antiprotozoal Drug Development and Delivery. Antiprotozoal Drug Development and Delivery 83 111 .
Clemente Capasso & Claudiu T. Supuran. 2022. Antiprotozoal Drug Development and Delivery. Antiprotozoal Drug Development and Delivery 241 258 .
Sizhu Ren, Shuhui Jiang, Xunyou Yan, Ruixue Chen & Huicui Cui. (2020) Challenges and Opportunities: Porous Supports in Carbonic Anhydrase Immobilization. Journal of CO2 Utilization 42, pages 101305.
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Lilia Clima, Bogdan Florin Craciun, Andrea Angeli, Andrea Petreni, Alessandro Bonardi, Alessio Nocentini, Fabrizio Carta, Paola Gratteri, Mariana Pinteala & Claudiu T. Supuran. (2020) Synthesis, Computational Studies and Assessment of in Vitro Activity of Squalene Derivatives as Carbonic Anhydrase Inhibitors . ChemMedChem 15:21, pages 2052-2057.
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Pavitra S. Thacker, Nerella Sridhar Goud, Omkar S. Argulwar, Jyothsna Soman, Andrea Angeli, Mallika Alvala, Mohammed Arifuddin & Claudiu T. Supuran. (2020) Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors. Bioorganic Chemistry 104, pages 104272.
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Colleen Manyumwa, Reza Emameh & Özlem Tastan Bishop. (2020) Alpha-Carbonic Anhydrases from Hydrothermal Vent Sources as Potential Carbon Dioxide Sequestration Agents: In Silico Sequence, Structure and Dynamics Analyses. International Journal of Molecular Sciences 21:21, pages 8066.
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Jatinder Kaur, Xufeng Cao, Nader S. Abutaleb, Ahmed Elkashif, Amanda L. Graboski, Aaron D. Krabill, Ahmed Hassan AbdelKhalek, Weiwei An, Atul Bhardwaj, Mohamed N. Seleem & Daniel P. Flaherty. (2020) Optimization of Acetazolamide-Based Scaffold as Potent Inhibitors of Vancomycin-Resistant Enterococcus . Journal of Medicinal Chemistry 63:17, pages 9540-9562.
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Andrea Angeli, Fabrizio Carta & Claudiu T. Supuran. (2020) Carbonic Anhydrases: Versatile and Useful Biocatalysts in Chemistry and Biochemistry. Catalysts 10:9, pages 1008.
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Aiga Grandāne, Alessio Nocentini, Ilona Domračeva, Raivis Žalubovskis & Claudiu T. Supuran. (2020) Development of oxathiino[6,5-b]pyridine 2,2-dioxide derivatives as selective inhibitors of tumor-related carbonic anhydrases IX and XII. European Journal of Medicinal Chemistry 200, pages 112300.
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Zan Li, Li Jiang & Shinya Toyokuni. (2020) Role of carbonic anhydrases in ferroptosis-resistance. Archives of Biochemistry and Biophysics 689, pages 108440.
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Shengyang Jin, Daniela Vullo, Silvia Bua, Alessio Nocentini, Claudiu T. Supuran & Yong-gui Gao. (2020) Structural and biochemical characterization of novel carbonic anhydrases from Phaeodactylum tricornutum . Acta Crystallographica Section D Structural Biology 76:7, pages 676-686.
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