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Editorials

Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles

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Article: 26913 | Published online: 22 Dec 2014

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Michiel Pegtel, Hector Peinado, Francesca Perut, Michael W Pfaffl, Donald G Phinney, Bartijn CH Pieters, Ryan C Pink, David S Pisetsky, Elke Pogge von Strandmann, Iva Polakovicova, Ivan KH Poon, Bonita H Powell, Ilaria Prada, Lynn Pulliam, Peter Quesenberry, Annalisa Radeghieri, Robert L Raffai, Stefania Raimondo, Janusz Rak, Marcel I Ramirez, Graça Raposo, Morsi S Rayyan, Neta Regev-Rudzki, Franz L Ricklefs, Paul D Robbins, David D Roberts, Silvia C Rodrigues, Eva Rohde, Sophie Rome, Kasper MA Rouschop, Aurelia Rughetti, Ashley E Russell, Paula Saá, Susmita Sahoo, Edison Salas-Huenuleo, Catherine Sánchez, Julie A Saugstad, Meike J Saul, Raymond M Schiffelers, Raphael Schneider, Tine Hiorth Schøyen, Aaron Scott, Eriomina Shahaj, Shivani Sharma, Olga Shatnyeva, Faezeh Shekari, Ganesh Vilas Shelke, Ashok K Shetty, Kiyotaka Shiba, Pia R-M Siljander, Andreia M Silva, Agata Skowronek, Orman L Snyder$suffix/text()$suffix/text(), Rodrigo Pedro Soares, Barbara W Sódar, Carolina Soekmadji, Javier Sotillo, Philip D Stahl, Willem Stoorvogel, Shannon L Stott, Erwin F Strasser, Simon Swift, Hidetoshi Tahara, Muneesh Tewari, Kate Timms, Swasti Tiwari, Rochelle Tixeira, Mercedes Tkach, Wei Seong Toh, Richard Tomasini, Ana Claudia Torrecilhas, Juan Pablo Tosar, Vasilis Toxavidis, Lorena Urbanelli, Pieter Vader, Bas WM van Balkom, Susanne G van der Grein, Jan Van Deun, Martijn JC van Herwijnen, Kendall Van Keuren-Jensen, Guillaume van Niel, Martin E van Royen, Andre J van Wijnen, M Helena Vasconcelos, Ivan J Vechetti$suffix/text()$suffix/text(), Tiago D Veit, Laura J Vella, Émilie Velot, Frederik J Verweij, Beate Vestad, Jose L Viñas, Tamás Visnovitz, Krisztina V Vukman, Jessica Wahlgren, Dionysios C Watson, Marca HM Wauben, Alissa Weaver, Jason P Webber, Viktoria Weber, Ann M Wehman, Daniel J Weiss, Joshua A Welsh, Sebastian Wendt, Asa M Wheelock, Zoltán Wiener, Leonie Witte, Joy Wolfram, Angeliki Xagorari, Patricia Xander, Jing Xu, Xiaomei Yan, María Yáñez-Mó, Hang Yin, Yuana Yuana, Valentina Zappulli, Jana Zarubova, Vytautas Žėkas, Jian-ye Zhang, Zezhou Zhao, Lei Zheng, Alexander R Zheutlin, Antje M Zickler, Pascale Zimmermann, Angela M Zivkovic, Davide Zocco & Ewa K Zuba-Surma. (2018) Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. Journal of Extracellular Vesicles 7:1.
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Tatyana Vagner, Cristiana Spinelli, Valentina R. Minciacchi, Leonora Balaj, Mandana Zandian, Andrew Conley, Andries Zijlstra, Michael R. Freeman, Francesca Demichelis, Subhajyoti De, Edwin M. Posadas, Hisashi Tanaka & Dolores Di Vizio. (2018) Large extracellular vesicles carry most of the tumour DNA circulating in prostate cancer patient plasma. Journal of Extracellular Vesicles 7:1.
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Andrew D. Foers, Simon Chatfield, Laura F. Dagley, Benjamin J. Scicluna, Andrew I. Webb, Lesley Cheng, Andrew F. Hill, Ian P. Wicks & Ken C. Pang. (2018) Enrichment of extracellular vesicles from human synovial fluid using size exclusion chromatography. Journal of Extracellular Vesicles 7:1.
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Eline Oeyen, Kurt Van Mol, Geert Baggerman, Hanny Willems, Kurt Boonen, Christian Rolfo, Patrick Pauwels, An Jacobs, Karin Schildermans, William C Cho & Inge Mertens. (2018) Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine. Journal of Extracellular Vesicles 7:1.
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Jonathan Degosserie, Charlotte Heymans, Catherine Spourquet, Mathias Halbout, Ludovic D’Auria, Patrick Van Der Smissen, Didier Vertommen, Pierre J. Courtoy, Donatienne Tyteca & Christophe E. Pierreux. (2018) Extracellular vesicles from endothelial progenitor cells promote thyroid follicle formation. Journal of Extracellular Vesicles 7:1.
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Dominik Buschmann, Benedikt Kirchner, Stefanie Hermann, Melanie Märte, Christine Wurmser, Florian Brandes, Stefan Kotschote, Michael Bonin, Ortrud K. Steinlein, Michael W. Pfaffl, Gustav Schelling & Marlene Reithmair. (2018) Evaluation of serum extracellular vesicle isolation methods for profiling miRNAs by next-generation sequencing. Journal of Extracellular Vesicles 7:1.
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Aled Clayton, Dominik Buschmann, J. Brian Byrd, David R. F. Carter, Lesley Cheng, Carolyn Compton, George Daaboul, Andrew Devitt, Juan Manuel Falcon-Perez, Chris Gardiner, Dakota Gustafson, Paul Harrison, Clemens Helmbrecht, An Hendrix, Andrew Hill, Andrew Hoffman, Jennifer C. Jones, Raghu Kalluri, Ji Yoon Kang, Benedikt Kirchner, Cecilia Lässer, Charlotte Lawson, Metka Lenassi, Carina Levin, Alicia Llorente, Elena S. Martens-Uzunova, Andreas Möller, Luca Musante, Takahiro Ochiya, Ryan C Pink, Hidetoshi Tahara, Marca H. M. Wauben, Jason P. Webber, Joshua A. Welsh, Kenneth W. Witwer, Hang Yin & Rienk Nieuwland. (2018) Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017. Journal of Extracellular Vesicles 7:1.
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David W. Greening & Richard J. Simpson. (2018) Understanding extracellular vesicle diversity – current status. Expert Review of Proteomics 15:11, pages 887-910.
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Birke J. Benedikter, Emiel F. M. Wouters, Paul H. M. Savelkoul, Gernot G. U. Rohde & Frank R. M. Stassen. (2018) Extracellular vesicles released in response to respiratory exposures: implications for chronic disease. Journal of Toxicology and Environmental Health, Part B 21:3, pages 142-160.
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Marco Tucci, Anna Passarelli, Francesco Mannavola, Luigia Stefania Stucci, Paolo Antonio Ascierto, Marilena Capone, Gabriele Madonna, Patrizia Lopalco & Francesco Silvestris. (2018) Serum exosomes as predictors of clinical response to ipilimumab in metastatic melanoma. OncoImmunology 7:2.
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Lisa König, Sabine Kasimir-Bauer, Ann-Kathrin Bittner, Oliver Hoffmann, Bettina Wagner, Luis Felipe Santos Manvailer, Rainer Kimmig, Peter A. Horn & Vera Rebmann. (2018) Elevated levels of extracellular vesicles are associated with therapy failure and disease progression in breast cancer patients undergoing neoadjuvant chemotherapy. OncoImmunology 7:1.
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Emma Budd, Giovanna Nalesso & Ali Mobasheri. (2018) Extracellular genomic biomarkers of osteoarthritis. Expert Review of Molecular Diagnostics 18:1, pages 55-74.
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Vanesa G. Martinez, Sadhbh O'Neill, Josephine Salimu, Susan Breslin, Aled Clayton, John Crown & Lorraine O'Driscoll. (2017) Resistance to HER2-targeted anti-cancer drugs is associated with immune evasion in cancer cells and their derived extracellular vesicles. OncoImmunology 6:12.
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Barbara W. Sódar, Árpád Kovács, Tamás Visnovitz, Éva Pállinger, Károly Vékey, Gabriella Pocsfalvi, Lilla Turiák & Edit I Buzás. (2017) Best practice of identification and proteomic analysis of extracellular vesicles in human health and disease. Expert Review of Proteomics 14:12, pages 1073-1090.
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Abderrahim Benmoussa, Sophia Ly, Si Ting Shan, Jonathan Laugier, Eric Boilard, Caroline Gilbert & Patrick Provost. (2017) A subset of extracellular vesicles carries the bulk of microRNAs in commercial dairy cow’s milk. Journal of Extracellular Vesicles 6:1.
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Chuan Wen, Robert C. Seeger, Muller Fabbri, Larry Wang, Alan S. Wayne & Ambrose Y. Jong. (2017) Biological roles and potential applications of immune cell-derived extracellular vesicles. Journal of Extracellular Vesicles 6:1.
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Kenneth W. Witwer, Carolina Soekmadji, Andrew F. Hill, Marca H. Wauben, Edit I. Buzás, Dolores Di Vizio, Juan M. Falcon-Perez, Chris Gardiner, Fred Hochberg, Igor V. Kurochkin, Jan Lötvall, Suresh Mathivanan, Rienk Nieuwland, Susmita Sahoo, Hidetoshi Tahara, Ana Claudia Torrecilhas, Alissa M. Weaver, Hang Yin, Lei Zheng, Yong Song Gho, Peter Quesenberry & Clotilde Théry. (2017) Updating the MISEV minimal requirements for extracellular vesicle studies: building bridges to reproducibility. Journal of Extracellular Vesicles 6:1.
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Kaloyan Takov, Derek M. Yellon & Sean M. Davidson. (2017) Confounding factors in vesicle uptake studies using fluorescent lipophilic membrane dyes. Journal of Extracellular Vesicles 6:1.
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Jan Van Deun & An Hendrix. (2017) Is your article EV-TRACKed?. Journal of Extracellular Vesicles 6:1.
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Rosario Maroto, Yingxin Zhao, Mohammad Jamaluddin, Vsevolod L. Popov, Hongwang Wang, Madumali Kalubowilage, Yueqing Zhang, Jonathan Luisi, Hong Sun, Christopher T. Culbertson, Stefan H. Bossmann, Massoud Motamedi & Allan R. Brasier. (2017) Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses. Journal of Extracellular Vesicles 6:1.
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Laura J. Vella, Benjamin J. Scicluna, Lesley Cheng, Emma G. Bawden, Colin L. Masters, Ching-Seng Ang, Nicholas Willamson, Catriona McLean, Kevin J. Barnham & Andrew F. Hill. (2017) A rigorous method to enrich for exosomes from brain tissue. Journal of Extracellular Vesicles 6:1.
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Beate Vestad, Alicia Llorente, Axl Neurauter, Santosh Phuyal, Bente Kierulf, Peter Kierulf, Tore Skotland, Kirsten Sandvig, Kari Bente F. Haug & Reidun Øvstebø. (2017) Size and concentration analyses of extracellular vesicles by nanoparticle tracking analysis: a variation study. Journal of Extracellular Vesicles 6:1.
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Dhruvitkumar S. Sutaria, Jinmai Jiang, Ola A. Elgamal, Steven M. Pomeroy, Mohamed Badawi, Xiaohua Zhu, Ryan Pavlovicz, Ana Clara P. Azevedo-Pouly, Jeffrey Chalmers, Chenglong Li, Mitch A. Phelps & Thomas D. Schmittgen. (2017) Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery. Journal of Extracellular Vesicles 6:1.
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Rie Nakata, Hiroyuki Shimada, G. Esteban Fernandez, Rob Fanter, Muller Fabbri, Jemily Malvar, Pascale Zimmermann & Yves A. DeClerck. (2017) Contribution of neuroblastoma-derived exosomes to the production of pro-tumorigenic signals by bone marrow mesenchymal stromal cells. Journal of Extracellular Vesicles 6:1.
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Priscila Dauros Singorenko, Vanessa Chang, Alana Whitcombe, Denis Simonov, Jiwon Hong, Anthony Phillips, Simon Swift & Cherie Blenkiron. (2017) Isolation of membrane vesicles from prokaryotes: a technical and biological comparison reveals heterogeneity. Journal of Extracellular Vesicles 6:1.
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Xiangju Wang, Ray Wilkinson, Katrina Kildey, Jeremy Potriquet, Jason Mulvenna, Richard J. Lobb, Andreas Möller, Nicole Cloonan, Pamela Mukhopadhyay, Andrew J. Kassianos & Helen Healy. (2017) Unique molecular profile of exosomes derived from primary human proximal tubular epithelial cells under diseased conditions. Journal of Extracellular Vesicles 6:1.
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Irene V. Bijnsdorp, Olga Maxouri, Aarzo Kardar, Tim Schelfhorst, Sander R. Piersma, Thang V. Pham, Andre Vis, R. Jeroen van Moorselaar & Connie R. Jimenez. (2017) Feasibility of urinary extracellular vesicle proteome profiling using a robust and simple, clinically applicable isolation method. Journal of Extracellular Vesicles 6:1.
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Maëva Durcin, Audrey Fleury, Emiliane Taillebois, Grégory Hilairet, Zuzana Krupova, Céline Henry, Sandrine Truchet, Martin Trötzmüller, Harald Köfeler, Guillaume Mabilleau, Olivier Hue, Ramaroson Andriantsitohaina, Patrice Martin & Soazig Le Lay. (2017) Characterisation of adipocyte-derived extracellular vesicle subtypes identifies distinct protein and lipid signatures for large and small extracellular vesicles. Journal of Extracellular Vesicles 6:1.
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Ambrose Y. Jong, Chun-Hua Wu, Jingbo Li, Jianping Sun, Muller Fabbri, Alan S. Wayne & Robert C. Seeger. (2017) Large-scale isolation and cytotoxicity of extracellular vesicles derived from activated human natural killer cells. Journal of Extracellular Vesicles 6:1.
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Kristine Blans, Maria S. Hansen, Laila V. Sørensen, Michael L. Hvam, Kenneth A. Howard, Arne Möller, Lars Wiking, Lotte B. Larsen & Jan T. Rasmussen. (2017) Pellet-free isolation of human and bovine milk extracellular vesicles by size-exclusion chromatography. Journal of Extracellular Vesicles 6:1.
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Chao Liu, Haiyan Gao, Peng Lv, Jingyi Liu & Gang Liu. (2017) Extracellular vesicles as an efficient nanoplatform for the delivery of therapeutics. Human Vaccines & Immunotherapeutics 13:11, pages 2678-2687.
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Edward Allan Racela Sison, Peter Kurre & Yong-Mi Kim. (2017) Understanding the bone marrow microenvironment in hematologic malignancies: A focus on chemokine, integrin, and extracellular vesicle signaling. Pediatric Hematology and Oncology 34:6-7, pages 365-378.
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Sarah Jeurissen, Glenn Vergauwen, Jan Van Deun, Lore Lapeire, Victoria Depoorter, Ilkka Miinalainen, Raija Sormunen, Rudy Van den Broecke, Geert Braems, Véronique Cocquyt, Hannelore Denys & An Hendrix. (2017) The isolation of morphologically intact and biologically active extracellular vesicles from the secretome of cancer-associated adipose tissue. Cell Adhesion & Migration 11:2, pages 196-204.
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Vincent Hyenne, Olivier Lefebvre & Jacky G. Goetz. (2017) Going live with tumor exosomes and microvesicles. Cell Adhesion & Migration 11:2, pages 173-186.
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David W. Greening, Rong Xu, Shashi K. Gopal, Alin Rai & Richard J. Simpson. (2017) Proteomic insights into extracellular vesicle biology – defining exosomes and shed microvesicles. Expert Review of Proteomics 14:1, pages 69-95.
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Cecilia Lässer, Clotilde Théry, Edit I. Buzás, Suresh Mathivanan, Weian Zhao, Yong Song Gho & Jan Lötvall. (2016) The International Society for Extracellular Vesicles launches the first massive open online course on extracellular vesicles. Journal of Extracellular Vesicles 5:1.
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Brian Meehan, Janusz Rak & Dolores Di Vizio. (2016) Oncosomes – large and small: what are they, where they came from?. Journal of Extracellular Vesicles 5:1.
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Chris Gardiner, Dolores Di Vizio, Susmita Sahoo, Clotilde Théry, Kenneth W. Witwer, Marca Wauben & Andrew F. Hill. (2016) Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey. Journal of Extracellular Vesicles 5:1.
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Tania Martins-Marques, Maria Joao Pinho, Monica Zuzarte, Carla Oliveira, Paulo Pereira, Joost P. G. Sluijter, Celia Gomes & Henrique Girao. (2016) Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin. Journal of Extracellular Vesicles 5:1.
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Janneke Boere, Chris H. A. van de Lest, Sten F. W. M. Libregts, Ger J. A. Arkesteijn, Willie J. C. Geerts, Esther N. M. Nolte-'t Hoen, Jos Malda, P. René van Weeren & Marca H. M. Wauben. (2016) Synovial fluid pretreatment with hyaluronidase facilitates isolation of CD44+ extracellular vesicles. Journal of Extracellular Vesicles 5:1.
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Joanne Louise Welton, Paul Brennan, Mark Gurney, Jason Paul Webber, Lisa Kate Spary, David Gil Carton, Juan Manuel Falcón-Pérez, Sean Peter Walton, Malcolm David Mason, Zsuzsanna Tabi & Aled Clayton. (2016) Proteomics analysis of vesicles isolated from plasma and urine of prostate cancer patients using a multiplex, aptamer-based protein array. Journal of Extracellular Vesicles 5:1.
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Kazuya Iwai, Tamiko Minamisawa, Kanako Suga, Yasutomo Yajima & Kiyotaka Shiba. (2016) Isolation of human salivary extracellular vesicles by iodixanol density gradient ultracentrifugation and their characterizations. Journal of Extracellular Vesicles 5:1.
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Ruenn Chai Lai, Soon Sim Tan, Ronne Wee Yeh Yeo, Andre Boon Hwa Choo, Agnes T. Reiner, Yan Su, Yang Shen, Zhiyan Fu, Lezhava Alexander, Siu Kwan Sze & Sai Kiang Lim. (2016) MSC secretes at least 3 EV types each with a unique permutation of membrane lipid, protein and RNA. Journal of Extracellular Vesicles 5:1.
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Larissa Belov, Kieran J. Matic, Susannah Hallal, O. Giles Best, Stephen P. Mulligan & Richard I. Christopherson. (2016) Extensive surface protein profiles of extracellular vesicles from cancer cells may provide diagnostic signatures from blood samples. Journal of Extracellular Vesicles 5:1.
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Akira Yokoi, Yusuke Yoshioka & Takahiro Ochiya. (2015) Towards the realization of clinical extracellular vesicle diagnostics: challenges and opportunities. Expert Review of Molecular Diagnostics 15:12, pages 1555-1566.
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Chien-Chung Lin, Wei-Lun Huang, Fang Wei, Wu-Chou Su & David T Wong. (2015) Emerging platforms using liquid biopsy to detect EGFR mutations in lung cancer. Expert Review of Molecular Diagnostics 15:11, pages 1427-1440.
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Esperanza González & Juan Manuel Falcón-Pérez. (2015) Cell-derived extracellular vesicles as a platform to identify low-invasive disease biomarkers. Expert Review of Molecular Diagnostics 15:7, pages 907-923.
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Hyungsoon Im, Huilin Shao, Ralph Weissleder, Cesar M Castro & Hakho Lee. (2015) Nano-plasmonic exosome diagnostics. Expert Review of Molecular Diagnostics 15:6, pages 725-733.
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Thomas Lener, Mario Gimona, Ludwig Aigner, Verena Börger, Edit Buzas, Giovanni Camussi, Nathalie Chaput, Devasis Chatterjee, Felipe A. Court, Hernando A. del Portillo, Lorraine O'Driscoll, Stefano Fais, Juan M. Falcon-Perez, Ursula Felderhoff-Mueser, Lorenzo Fraile, Yong Song Gho, André Görgens, Ramesh C. Gupta, An Hendrix, Dirk M. Hermann, Andrew F. Hill, Fred Hochberg, Peter A. Horn, Dominique de Kleijn, Lambros Kordelas, Boris W. Kramer, Eva-Maria Krämer-Albers, Sandra Laner-Plamberger, Saara Laitinen, Tommaso Leonardi, Magdalena J. Lorenowicz, Sai Kiang Lim, Jan Lötvall, Casey A. Maguire, Antonio Marcilla, Irina Nazarenko, Takahiro Ochiya, Tushar Patel, Shona Pedersen, Gabriella Pocsfalvi, Stefano Pluchino, Peter Quesenberry, Ilona G. Reischl, Francisco J. Rivera, Ralf Sanzenbacher, Katharina Schallmoser, Ineke Slaper-Cortenbach, Dirk Strunk, Torsten Tonn, Pieter Vader, Bas W. M. van Balkom, Marca Wauben, Samir El Andaloussi, Clotilde Théry, Eva Rohde & Bernd Giebel. (2015) Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper. Journal of Extracellular Vesicles 4:1.
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Bradley Whitehead, LinPing Wu, Michael Lykke Hvam, Husnu Aslan, Mingdong Dong, Lars Dyrskjøt, Marie Stampe Ostenfeld, Seyed Moein Moghimi & Kenneth Alan Howard. (2015) Tumour exosomes display differential mechanical and complement activation properties dependent on malignant state: implications in endothelial leakiness. Journal of Extracellular Vesicles 4:1.
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Yuana Yuana, Anita N. Böing, Anita E. Grootemaat, Edwin van der Pol, Chi M. Hau, Petr Cizmar, Egbert Buhr, Auguste Sturk & Rienk Nieuwland. (2015) Handling and storage of human body fluids for analysis of extracellular vesicles. Journal of Extracellular Vesicles 4:1.
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Zachary J. Smith, Changwon Lee, Tatu Rojalin, Randy P. Carney, Sidhartha Hazari, Alisha Knudson, Kit Lam, Heikki Saari, Elisa Lazaro Ibañez, Tapani Viitala, Timo Laaksonen, Marjo Yliperttula & Sebastian Wachsmann-Hogiu. (2015) Single exosome study reveals subpopulations distributed among cell lines with variability related to membrane content. Journal of Extracellular Vesicles 4:1.
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Carsten Frühbeis, Susanne Helmig, Suzan Tug, Perikles Simon & Eva-Maria Krämer-Albers. (2015) Physical exercise induces rapid release of small extracellular vesicles into the circulation. Journal of Extracellular Vesicles 4:1.
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Alexander N. Kapustin, Natalia Kalinina, Tatiana Lopatina, Sean M. Davidson, Nunzio Iraci, Svetlana Tamkovich, Lesley Smyth, Dmitry Ter-Ovanesyan, Evgeniy G. Evtushenko, Olga Savelieva, Sergio Bertazzo, Vassiliy Aushev, Rebecca Dragovic, Tannia Gracia, Margarete Heck, Yelena V. Parfyonova, Catherine M. Shanahan & Vsevolod Tkachuk. (2015) UK–Russia Researcher Links Workshop: extracellular vesicles – mechanisms of biogenesis and roles in disease pathogenesis, M.V. Lomonosov Moscow State University, Moscow, Russia, 1–5 March 2015. Journal of Extracellular Vesicles 4:1.
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Inés Lozano-Ramos, Ioana Bancu, Anna Oliveira-Tercero, María Pilar Armengol, Armando Menezes-Neto, Hernando A. Del Portillo, Ricardo Lauzurica-Valdemoros & Francesc E. Borràs. (2015) Size-exclusion chromatography-based enrichment of extracellular vesicles from urine samples. Journal of Extracellular Vesicles 4:1.
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Richard J. Lobb, Melanie Becker, Shu Wen Wen, Christina S. F. Wong, Adrian P. Wiegmans, Antoine Leimgruber & Andreas Möller. (2015) Optimized exosome isolation protocol for cell culture supernatant and human plasma. Journal of Extracellular Vesicles 4:1.
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Louise C. Laurent, Asim B. Abdel-Mageed, P. David Adelson, Jorge Arango, Leonora Balaj, Xandra Breakefield, Elizabeth Carlson, Bob S. Carter, Blanca Majem, Clark C. Chen, Emanuele Cocucci, Kirsty Danielson, Amanda Courtright, Saumya Das, Zakaria Y. Abd Elmageed, Daniel Enderle, Alan Ezrin, Marc Ferrer, Jane Freedman, David Galas, Roopali Gandhi, Matthew J. Huentelman, Kendall Van Keuren-Jensen, Yashar Kalani, Yong Kim, Anna M. Krichevsky, Charles Lai, Madhu Lal-Nag, Clara D. Laurent, Trevor Leonardo, Feng Li, Ivana Malenica, Debasis Mondal, Parham Nejad, Tushar Patel, Robert L. Raffai, Renee Rubio, Johan Skog, Robert Spetzler, Jie Sun, Kahraman Tanriverdi, Kasey Vickers, Liang Wang, Yaoyu Wang, Zhiyun Wei, Howard L. Weiner, David Wong, Irene K. Yan, Ashish Yeri & Stephen Gould. (2015) Meeting report: discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium. Journal of Extracellular Vesicles 4:1.
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Manuel Alejandro Picon, Liyong Wang, Andrea Da Fonseca Ferreira, Chunming Dong & George R. Marzouka. (2023) Extracellular Vesicles as Delivery Systems in Disease Therapy. International Journal of Molecular Sciences 24:24, pages 17134.
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Peng Wang, Onno J. Arntz, Johanna F. A. Husch, Van der Kraan P. M.Jeroen J. J. P. van den Beucken & Fons A. J. van de Loo. (2023) Polyethylene glycol precipitation is an efficient method to obtain extracellular vesicle-depleted fetal bovine serum. PLOS ONE 18:12, pages e0295076.
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Peijie Wu, Wenjun Wu, Shu Zhang, Jun Han, Chao Liu, Han Yu, Xiping Chen & Xiaofeng Chen. (2023) Therapeutic potential and pharmacological significance of extracellular vesicles derived from traditional medicinal plants. Frontiers in Pharmacology 14.
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Sonal Sukreet, Camila Pereira Braga, Jiri Adamec, Juan Cui & Janos Zempleni. (2023) The absorption of bovine milk small extracellular vesicles largely depends on galectin 3 and galactose ligands in human intestinal cells and C57BL/6J mice. American Journal of Physiology-Cell Physiology 325:6, pages C1421-C1430.
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Ricardo Malvicini, Giada De Lazzari, Anna Maria Tolomeo, Diego Santa-Cruz, Mujib Ullah, Carmine Cirillo, Paolo Grumati, Natalia Pacienza, Maurizio Muraca & Gustavo Yannarelli. (2023) Influence of the isolation method on characteristics and functional activity of mesenchymal stromal cell-derived extracellular vesicles. Cytotherapy.
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Manar A. Didamoony, Ayman A. Soubh, Ahmed M. Atwa & Lamiaa A. Ahmed. (2023) Innovative preconditioning strategies for improving the therapeutic efficacy of extracellular vesicles derived from mesenchymal stem cells in gastrointestinal diseases. Inflammopharmacology 31:6, pages 2973-2993.
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Fabrice Lucien, Dakota Gustafson, Metka Lenassi, Bo Li, Jacob J. Teske, Eric Boilard, Katharina Clemm von Hohenberg, Juan Manual Falcón‐Perez, Alice Gualerzi, Antonia Reale, Jennifer C. Jones, Cecilia Lässer, Charlotte Lawson, Irina Nazarenko, Lorraine O'Driscoll, Ryan Pink, Pia R‐M Siljander, Carolina Soekmadji, An Hendrix, Joshua A Welsh, Kenneth W. Witwer & Rienk Nieuwland. (2023) MIBlood‐EV: Minimal information to enhance the quality and reproducibility of blood extracellular vesicle research. Journal of Extracellular Vesicles 12:12.
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Germano Aguiar Ferreira, Carolina Hassibe Thomé, Clarice Izumi, Mariana Lopes Grassi, Guilherme Pauperio Lanfredi, Marcus Smolka, Vitor Marcel Faça & Francisco José Candido dos Reis. (2023) Proteomic analysis of exosomes secreted during the epithelial-mesenchymal transition and potential biomarkers of mesenchymal high-grade serous ovarian carcinoma. Journal of Ovarian Research 16:1.
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Anna Maria Ciaccio & Antonino Tuttolomondo. (2023) Exosomal miRNAs as Biomarkers of Ischemic Stroke. Brain Sciences 13:12, pages 1647.
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Bo Han, William Fang, Zhi Yang, Yuntao Wang, Shuqing Zhao, Ba Xuan Hoang & C. Thomas VangsnessJr.Jr.. (2023) Enhancement of Chondrogenic Markers by Exosomes Derived from Cultured Human Synovial Fluid-Derived Cells: A Comparative Analysis of 2D and 3D Conditions. Biomedicines 11:12, pages 3145.
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Maria Giovanna Ciliberti, Antonella Santillo, Agostino Sevi, Marzia Albenzio, Vincenzo De Leo, Chiara Ingrosso, Lucia Catucci & Mariangela Caroprese. (2023) First insight into extracellular vesicle-miRNA characterization in a sheep in vitro model of inflammation. Frontiers in Veterinary Science 10.
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Xiaorong Yin, Lizhi Lin, Fang Fang, Bin Zhang & Cheng Shen. (2023) Mechanisms and Optimization Strategies of Paracrine Exosomes from Mesenchymal Stem Cells in Ischemic Heart Disease. Stem Cells International 2023, pages 1-20.
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S LV, G WANG, L DAI, T WANG & F WANG. (2023) Cellular and Molecular Connections Between Bone Fracture Healing and Exosomes. Physiological Research 72:5, pages 565-574.
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Christopher D. Gregory. (2023) Hijacking homeostasis: Regulation of the tumor microenvironment by apoptosis. Immunological Reviews 319:1, pages 100-127.
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