Pharmaceutical Biology, Volume 59, Issue 1 (2021)

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Pharmaceutical Biology, Volume 59, Issue 1 (2021)

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PERSPECTIVE

Editorial
In memoriam – Dr. Mahabir Gupta 1942–2020
Valdir Cechinel-Filho
Pages: (i)-(ii)
Published online: 03 Feb 2021
CitationforIn memoriam – Dr. Mahabir Gupta 1942–2020 | Full Text | PDF (320.8 KB) | EPUB
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Research Article

Article
Accelerative effect of topical Zataria multiflora essential oil against infected wound model by modulating inflammation, angiogenesis, and collagen biosynthesis
Mohammad Reza Farahpour, Sara Sheikh, Elham Kafshdooz & Ali Sonboli
Pages: 1-10
Published online: 30 Dec 2020
AbstractforAccelerative effect of topical Zataria multiflora essential oil against infected wound model by modulating inflammation, angiogenesis, and collagen biosynthesis | Full Text | References | PDF (3.1 MB) | EPUB
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Article
α-Hederin inhibits the growth of lung cancer A549 cells in vitro and in vivo by decreasing SIRT6 dependent glycolysis
Cong Fang, Yahui Liu, Lanying Chen, Yingying Luo, Yaru Cui, Ni Zhang, Peng Liu, Mengjing Zhou & Yongyan Xie
Pages: 11-20
Published online: 27 Dec 2020
Abstractforα-Hederin inhibits the growth of lung cancer A549 cells in vitro and in vivo by decreasing SIRT6 dependent glycolysis | Full Text | References | PDF (3.8 MB) | EPUB
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RESEARCH ARTICLE

Article
Berberine regulates the Notch1/PTEN/PI3K/AKT/mTOR pathway and acts synergistically with 17-AAG and SAHA in SW480 colon cancer cells
Ge Li, Chuang Zhang, Wei Liang, Yanbing Zhang, Yunheng Shen & Xinhui Tian
Pages: 21-30
Published online: 08 Jan 2021
AbstractforBerberine regulates the Notch1/PTEN/PI3K/AKT/mTOR pathway and acts synergistically with 17-AAG and SAHA in SW480 colon cancer cells | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Hepatoprotective effect of Pandanus odoratissimus seed extracts on paracetamol-induced rats
Ernawati Sinaga, Ami Fitrayadi, Asrori Asrori, Sri Endarti Rahayu, Suprihatin Suprihatin & Vivitri Dewi Prasasty
Pages: 31-39
Published online: 06 Jan 2021
AbstractforHepatoprotective effect of Pandanus odoratissimus seed extracts on paracetamol-induced rats | Full Text | References | PDF (1.8 MB) | EPUB
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Research Article

Article
Comparison of the antioxidant activities of nonfumigated and sulphur-fumigated Chrysanthemum morifolium cv. Hang-ju induced by oxidative stress
Hongyan Ma, Shanshan Liu, Wenshan Qu, Qi Huang, Linyuan Li, Fujiang Chu, Yuyun Zhu, Xinlin Lv, Zhimin Wang & Jingjing Zhu
Pages: 40-46
Published online: 05 Jan 2021
AbstractforComparison of the antioxidant activities of nonfumigated and sulphur-fumigated Chrysanthemum morifolium cv. Hang-ju induced by oxidative stress | Full Text | References | PDF (1.1 MB) | EPUB
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Article
Targeting CD155 by rediocide-A overcomes tumour immuno-resistance to natural killer cells
Wanyi Ng, Chenyuan Gong, Xuewei Yan, Guifan Si, Chen Fang, Lixin Wang, Xiaowen Zhu, Zihang Xu, Chao Yao & Shiguo Zhu
Pages: 47-53
Published online: 05 Jan 2021
AbstractforTargeting CD155 by rediocide-A overcomes tumour immuno-resistance to natural killer cells | Full Text | References | PDF (2 MB) | EPUB
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Article
Bersaldegenin-1,3,5-orthoacetate induces caspase-independent cell death, DNA damage and cell cycle arrest in human cervical cancer HeLa cells
Justyna Stefanowicz-Hajduk, Magdalena Gucwa, Barbara Moniuszko-Szajwaj, Anna Stochmal, Anna Kawiak & J. Renata Ochocka
Pages: 54-65
Published online: 06 Jan 2021
AbstractforBersaldegenin-1,3,5-orthoacetate induces caspase-independent cell death, DNA damage and cell cycle arrest in human cervical cancer HeLa cells | Full Text | References | PDF (3.7 MB) | EPUB
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Article
Ficus deltoidea promotes bone formation in streptozotocin-induced diabetic rats
Nurdiana Samsulrizal, Yong-Meng Goh, Hafandi Ahmad, Sulaiman Md Dom, Nur Syimal’ain Azmi, Noor Syaffinaz NoorMohamad Zin & Mahdi Ebrahimi
Pages: 66-73
Published online: 05 Jan 2021
AbstractforFicus deltoidea promotes bone formation in streptozotocin-induced diabetic rats | Full Text | References | PDF (1.5 MB) | EPUB
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Article
Sauropus brevipes ethanol extract negatively regulates inflammatory responses in vivo and in vitro by targeting Src, Syk and IRAK1
Ji Hye Kim, Jae Gwang Park, Yo Han Hong, Kon Kuk Shin, Jin Kyeong Kim, Young-Dong Kim, Ki Dong Yoon, Kyung-Hee Kim, Byong Chul Yoo, Gi-Ho Sung & Jae Youl Cho
Pages: 74-86
Published online: 13 Jan 2021
AbstractforSauropus brevipes ethanol extract negatively regulates inflammatory responses in vivo and in vitro by targeting Src, Syk and IRAK1 | Full Text | References | PDF (3.2 MB) | EPUB
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Article
Tanshinone IIA attenuates AOM/DSS-induced colorectal tumorigenesis in mice via inhibition of intestinal inflammation
Lijie Liu, Hanjing Gao, Tao Wen, Tao Gu, Shuang Zhang & Zhiyong Yuan
Pages: 87-94
Published online: 03 Feb 2021
AbstractforTanshinone IIA attenuates AOM/DSS-induced colorectal tumorigenesis in mice via inhibition of intestinal inflammation | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Artesunate alleviates the inflammatory response of ulcerative colitis by regulating the expression of miR-155
Zhao-Bin Yang, Lu-Zhen Qiu, Quan Chen & Jian-Dong Lin
Pages: 95-103
Published online: 01 Feb 2021
AbstractforArtesunate alleviates the inflammatory response of ulcerative colitis by regulating the expression of miR-155 | Full Text | References | PDF (2.5 MB) | EPUB
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Article
Ginsenoside Rg2 alleviates myocardial fibrosis by regulating TGF-β1/Smad signalling pathway
Quanwei Wang, Wenwen Fu, Xiaofeng Yu, Huali Xu, Dayun Sui & Yeling Wang
Pages: 104-111
Published online: 03 Feb 2021
AbstractforGinsenoside Rg2 alleviates myocardial fibrosis by regulating TGF-β1/Smad signalling pathway | Full Text | References | PDF (2 MB) | EPUB
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Article
Eucalyptol ameliorates early brain injury after subarachnoid haemorrhage via antioxidant and anti-inflammatory effects in a rat model
Gang Xu, Junsheng Guo & Chunming Sun
Pages: 112-118
Published online: 08 Feb 2021
AbstractforEucalyptol ameliorates early brain injury after subarachnoid haemorrhage via antioxidant and anti-inflammatory effects in a rat model | Full Text | References | PDF (1.5 MB) | EPUB
  • 3085 Views
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Article
Berberine attenuates septic cardiomyopathy by inhibiting TLR4/NF-κB signalling in rats
Huiqi Chen, Qian Liu, Xiangqi Liu & Jinlan Jin
Pages: 119-126
Published online: 04 Feb 2021
AbstractforBerberine attenuates septic cardiomyopathy by inhibiting TLR4/NF-κB signalling in rats | Full Text | References | PDF (1.9 MB) | EPUB
  • 3487 Views
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Article
Pharmacokinetic interaction between peimine and paeoniflorin in rats and its potential mechanism
Qiangjun Chen, Changlong Yin, Yongwei Li, Zhe Yang & Zongying Tian
Pages: 127-131
Published online: 15 Mar 2021
AbstractforPharmacokinetic interaction between peimine and paeoniflorin in rats and its potential mechanism | Full Text | References | PDF (840.6 KB) | EPUB
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Article
Alantolactone alleviates collagen-induced arthritis and inhibits Th17 cell differentiation through modulation of STAT3 signalling
Hsiang-Lai Chen, Shih Chao Lin, Shiming Li, Kuo-Tung Tang & Chi-Chien Lin
Pages: 132-143
Published online: 08 Feb 2021
AbstractforAlantolactone alleviates collagen-induced arthritis and inhibits Th17 cell differentiation through modulation of STAT3 signalling | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Kaempferol suppresses acetaminophen-induced liver damage by upregulation/activation of SIRT1
Mona Nasser BinMowyna & Nora Abdullah AlFaris
Pages: 144-154
Published online: 08 Feb 2021
AbstractforKaempferol suppresses acetaminophen-induced liver damage by upregulation/activation of SIRT1 | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Effects of epigallocatechin-3-gallate combined with ascorbic acid and glycerol on the stability and uric acid-lowering activity of epigallocatechin-3-gallate
Qianjin Xie, Xiaqiang Cai, Xu Dong, Ying Wang, Minghui Sun, Lingling Tai & Yan Xu
Pages: 155-164
Published online: 08 Feb 2021
AbstractforEffects of epigallocatechin-3-gallate combined with ascorbic acid and glycerol on the stability and uric acid-lowering activity of epigallocatechin-3-gallate | Full Text | References | PDF (3.6 MB) | EPUB
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Article
Effect of leech-centipede medicine on improving erectile function in diabetes-induced erectile dysfunction rats via PDE5 signalling pathway-related molecules
Ji-Sheng Wang, Jun-Long Feng, Xiao Li, Zi-Long Chen, Bing-Hao Bao, Sheng Deng, Heng-Heng Dai, Fan-Chao Meng, Bin Wang & Hai-Song Li
Pages: 165-172
Published online: 11 Feb 2021
AbstractforEffect of leech-centipede medicine on improving erectile function in diabetes-induced erectile dysfunction rats via PDE5 signalling pathway-related molecules | Full Text | References | PDF (1.3 MB) | EPUB
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Article

Article
Inosine induces acute hyperuricaemia in rhesus monkey (Macaca mulatta) as a potential disease animal model
Dong-hong Tang, Chen-yun Wang, Xi Huang, Hong-kun Yi, Zhe-li Li, Kai-li Ma, You-song Ye & Jian-wen Zhang
Pages: 173-180
Published online: 14 Mar 2021
AbstractforInosine induces acute hyperuricaemia in rhesus monkey (Macaca mulatta) as a potential disease animal model | Full Text | References | PDF (1.7 MB) | EPUB
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Research Article

Article
Icariin improves brain function decline in aging rats by enhancing neuronal autophagy through the AMPK/mTOR/ULK1 pathway
Jie Zheng, Shanshan Hu, Jinxin Wang, Xulan Zhang, Ding Yuan, Changcheng Zhang, Chaoqi Liu, Ting Wang & Zhiyong Zhou
Pages: 181-189
Published online: 08 Feb 2021
AbstractforIcariin improves brain function decline in aging rats by enhancing neuronal autophagy through the AMPK/mTOR/ULK1 pathway | Full Text | References | PDF (2.8 MB) | EPUB
  • 4715 Views
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Article

Article
Evodiamine protects against airway remodelling and inflammation in asthmatic rats by modulating the HMGB1/NF-κB/TLR-4 signalling pathway
Qiong Wang, Yubao Cui, Xufeng Wu & Junfang Wang
Pages: 190-197
Published online: 12 Feb 2021
AbstractforEvodiamine protects against airway remodelling and inflammation in asthmatic rats by modulating the HMGB1/NF-κB/TLR-4 signalling pathway | Full Text | References | PDF (1.8 MB) | EPUB
  • 3082 Views
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Research Article

Article
Influence of verapamil on the pharmacokinetics of rotundic acid in rats and its potential mechanism
Haihua Shang, Ze Wang, Hong Ma, Yinghui Sun, Xiaoyan Ci, Yuan Gu, Changxiao Liu & Duanyun Si
Pages: 198-206
Published online: 17 Feb 2021
AbstractforInfluence of verapamil on the pharmacokinetics of rotundic acid in rats and its potential mechanism | Full Text | References | PDF (1.4 MB) | EPUB
  • 2209 Views
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Article
Protective effects of Re-yan-ning mixture on Streptococcus pneumonia in rats based on network pharmacology
Lizhu Han, Jing Kou, Kunxia Hu, Yunlan Wang, Zhishu Tang, Zhisheng Wu & Xiao Song
Pages: 207-219
Published online: 07 Mar 2021
AbstractforProtective effects of Re-yan-ning mixture on Streptococcus pneumonia in rats based on network pharmacology | Full Text | References | PDF (5.1 MB) | EPUB
  • 2702 Views
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Article
Cardioprotective effect of rosmarinic acid against myocardial ischaemia/reperfusion injury via suppression of the NF-κB inflammatory signalling pathway and ROS production in mice
Wei Quan, Hui-xian Liu, Wei Zhang, Wei-juan Lou, Yang-ze Gong, Chong Yuan, Qing Shao, Na Wang, Chao Guo & Fei Liu
Pages: 220-229
Published online: 18 Feb 2021
AbstractforCardioprotective effect of rosmarinic acid against myocardial ischaemia/reperfusion injury via suppression of the NF-κB inflammatory signalling pathway and ROS production in mice | Full Text | References | PDF (2.1 MB) | EPUB
  • 2800 Views
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Article
Andrographolide emeliorates maltol aluminium-induced neurotoxicity via regulating p62-mediated Keap1-Nrf2 pathways in PC12 cells
Jiaqi Lu, Lili Gu, Qin Li, Ningzi Wu, Hongxing Li & Xinyue Zhang
Pages: 230-239
Published online: 26 Feb 2021
AbstractforAndrographolide emeliorates maltol aluminium-induced neurotoxicity via regulating p62-mediated Keap1-Nrf2 pathways in PC12 cells | Full Text | References | PDF (3.6 MB) | EPUB
  • 2949 Views
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Article

Article
Evaluation of the anti-inflammatory and antioxidant pharmcodynamic compoents of naoxintong capsules as a basis of broad spectrum effects
Bin Lv, Lina Deng, Tian Xie, Xing Wei, Xiao Liu, Wangxiao Tan, Xiaoying Wang & Xiumei Gao
Pages: 240-249
Published online: 19 Apr 2021
AbstractforEvaluation of the anti-inflammatory and antioxidant pharmcodynamic compoents of naoxintong capsules as a basis of broad spectrum effects | Full Text | References | PDF (2.1 MB) | EPUB
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Research Article

Article
Naoxintong accelerates diabetic wound healing by attenuating inflammatory response
Leyu Fang, Lu Chen, Min Song, Juan He, Lusha Zhang, Chunxiao Li, Qianyi Wang, Wenjie Yang, Wei Sun, Yuze Leng, Hong Shi, Shaoxia Wang, Xiumei Gao & Hong Wang
Pages: 250-259
Published online: 08 Mar 2021
AbstractforNaoxintong accelerates diabetic wound healing by attenuating inflammatory response | Full Text | References | PDF (2.7 MB) | EPUB
  • 3760 Views
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Article
Guizhi-Shaoyao-Zhimu decoction attenuates bone erosion in rats that have collagen-induced arthritis via modulating NF‐κB signalling to suppress osteoclastogenesis
Shu-jun Wei, Qing Zhang, Yong-jing Xiang, Lan-yu Peng, Wei Peng, Qiang Ren & Yong-xiang Gao
Pages: 260-272
Published online: 24 Feb 2021
AbstractforGuizhi-Shaoyao-Zhimu decoction attenuates bone erosion in rats that have collagen-induced arthritis via modulating NF‐κB signalling to suppress osteoclastogenesis | Full Text | References | PDF (4.9 MB) | EPUB
  • 2758 Views
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Article
Hypouricaemic and nephroprotective effects of Poria cocos in hyperuricemic mice by up-regulating ATP-binding cassette super-family G member 2
Danling Liang, Tianqiao Yong, Xue Diao, Shaodan Chen, Diling Chen, Chun Xiao, Dan Zuo, Yizhen Xie, Xinxin Zhou & Huiping Hu
Pages: 273-284
Published online: 02 Mar 2021
AbstractforHypouricaemic and nephroprotective effects of Poria cocos in hyperuricemic mice by up-regulating ATP-binding cassette super-family G member 2 | Full Text | References | PDF (3.9 MB) | EPUB
  • 2682 Views
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Review Article

Review
A review of anti-inflammatory, antioxidant, and immunomodulatory effects of Allium cepa and its main constituents
Narges Marefati, Vahideh Ghorani, Farzaneh Shakeri, Marzie Boskabady, Farzaneh Kianian, Ramin Rezaee & Mohammad Hosein Boskabady
Pages: 285-300
Published online: 28 Feb 2021
AbstractforA review of anti-inflammatory, antioxidant, and immunomodulatory effects of Allium cepa and its main constituents | Full Text | References | PDF (1.7 MB) | EPUB
  • 11110 Views
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Research Article

Article
The anti-breast cancer property of physcion via oxidative stress-mediated mitochondrial apoptosis and immune response
Luping Zhang, Ruitao Dong, Yu Wang, Longxiang Wang, Tian Zhou, Dongxu Jia & Zhaoli Meng
Pages: 301-308
Published online: 14 Mar 2021
AbstractforThe anti-breast cancer property of physcion via oxidative stress-mediated mitochondrial apoptosis and immune response | Full Text | References | PDF (2 MB) | EPUB
  • 2724 Views
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Article
Aconiti lateralis Radix Praeparata inhibits Alzheimer’s disease by regulating the complex regulation network with the core of GRIN1 and MAPK1
Yutao Wang, Huixiang Zhang, Jing Wang, Ming Yu, Qianqian Zhang, Shan Yan, Dingyun You, Lanlan Shi, Lihuan Zhang, Limei Wang, Hongxiang Wu & Xue Cao
Pages: 309-318
Published online: 30 Mar 2021
AbstractforAconiti lateralis Radix Praeparata inhibits Alzheimer’s disease by regulating the complex regulation network with the core of GRIN1 and MAPK1 | Full Text | References | PDF (2.4 MB) | EPUB
  • 2594 Views
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Article
Anti-inflammatory, expectorant, and antitussive properties of Kyeongok-go in ICR mice
Jin-Ryul Hu, Chul-Jong Jung, Seong-Min Ku, Dae-Hwa Jung, Khawaja Muhammad Imran Bashir, Sae-Kwang Ku & Jae-Suk Choi
Pages: 319-332
Published online: 26 Mar 2021
AbstractforAnti-inflammatory, expectorant, and antitussive properties of Kyeongok-go in ICR mice | Full Text | References | PDF (4.1 MB) | EPUB
  • 2875 Views
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Review article

Review
Study on the protective effects of danshen-honghua herb pair (DHHP) on myocardial ischaemia/reperfusion injury (MIRI) and potential mechanisms based on apoptosis and mitochondria
Jiqing Bai, Xiaoping Wang, Shaobing Du, Pengfei Wang, Yaheng Wang, Lina Quan & Yundong Xie
Pages: 333-344
Published online: 27 Jan 2022
AbstractforStudy on the protective effects of danshen-honghua herb pair (DHHP) on myocardial ischaemia/reperfusion injury (MIRI) and potential mechanisms based on apoptosis and mitochondria | Full Text | References | PDF (2.6 MB) | EPUB
  • 2006 Views
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Research Article

Article
Identification of the protective effect of Polygonatum sibiricum polysaccharide on d-galactose-induced brain ageing in mice by the systematic characterization of a circular RNA-associated ceRNA network
Zheyu Zhang, Bo Yang, Jianhua Huang, Wenqun Li, Pengji Yi, Min Yi & Weijun Peng
Pages: 345-364
Published online: 01 Apr 2021
AbstractforIdentification of the protective effect of Polygonatum sibiricum polysaccharide on d-galactose-induced brain ageing in mice by the systematic characterization of a circular RNA-associated ceRNA network | Full Text | References | PDF (3.3 MB) | EPUB
  • 3365 Views
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Article
Acute enhancing effect of a standardized extract of Centella asiatica (ECa 233) on synaptic plasticity: an investigation via hippocampal long-term potentiation
Yingrak Boondam, Mayuree H. Tantisira, Kanokwan Tilokskulchai, Sompol Tapechum & Narawut Pakaprot
Pages: 365-372
Published online: 31 Mar 2021
AbstractforAcute enhancing effect of a standardized extract of Centella asiatica (ECa 233) on synaptic plasticity: an investigation via hippocampal long-term potentiation | Full Text | References | PDF (1.3 MB) | EPUB
  • 2276 Views
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Article
Effect of Lupinus rotundiflorus gamma conglutin treatment on JNK1 gene expression and protein activation in a rat model of type 2 diabetes
Andrea Catalina Zepeda-Peña, Carmen Magdalena Gurrola-Díaz, José Alfredo Domínguez-Rosales, Pedro Macedonio García-López, Juan Carlos Pizano-Andrade, Zamira Helena Hernández-Nazará & Belinda Vargas-Guerrero
Pages: 373-379
Published online: 30 Mar 2021
AbstractforEffect of Lupinus rotundiflorus gamma conglutin treatment on JNK1 gene expression and protein activation in a rat model of type 2 diabetes | Full Text | References | PDF (1.6 MB) | EPUB
  • 2523 Views
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Article
Pueraria lobata root polysaccharide alleviates glucose and lipid metabolic dysfunction in diabetic db/db mice
Dan Luo, Xiaokang Dong, Jie Huang, Chengcheng Huang, Guowei Fang & Yanqin Huang
Pages: 380-388
Published online: 01 Apr 2021
AbstractforPueraria lobata root polysaccharide alleviates glucose and lipid metabolic dysfunction in diabetic db/db mice | Full Text | References | PDF (2.6 MB) | EPUB
  • 3928 Views
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Article
Antioxidant and antifatigue effect of a standardized fraction (HemoHIM) from Angelica gigas, Cnidium officinale, and Paeonia lactiflora
Da-Ae Kwon, Yong Sang Kim, Seul-Ki Kim, Sin Hwa Baek, Hyun Kyu Kim & Hak Sung Lee
Pages: 389-398
Published online: 04 Apr 2021
AbstractforAntioxidant and antifatigue effect of a standardized fraction (HemoHIM) from Angelica gigas, Cnidium officinale, and Paeonia lactiflora | Full Text | References | PDF (2.3 MB) | EPUB
  • 9566 Views
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Article
Pomelo peel oil suppresses TNF-α-induced necroptosis and cerebral ischaemia–reperfusion injury in a rat model of cardiac arrest
Wenyan Wang, Lu Xie, Xinsen Zou, Wanxiang Hu, Xinyue Tian, Gaoyang Zhao & Menghua Chen
Pages: 399-407
Published online: 01 Apr 2021
AbstractforPomelo peel oil suppresses TNF-α-induced necroptosis and cerebral ischaemia–reperfusion injury in a rat model of cardiac arrest | Full Text | References | PDF (2.9 MB) | EPUB
  • 2724 Views
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Article
Vinegar-processed Curcuma phaeocaulis promotes anti-angiogenic activity and reduces toxicity in zebrafish and rat models
Wan Liao, Yi Chen, Zongping Zhu, Jiao Chen, Tianhui Gao, Boonjai Limsila, Yenchit Techadamrongsin, Lei Wang, Jiali Yu, Chaomei Fu & Rui Li
Pages: 408-415
Published online: 23 May 2021
AbstractforVinegar-processed Curcuma phaeocaulis promotes anti-angiogenic activity and reduces toxicity in zebrafish and rat models | Full Text | References | PDF (1.4 MB) | EPUB
  • 2236 Views
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Brief Report
The anti-depressant effects of a novel PDE4 inhibitor derived from resveratrol
Yingcong Yu, Jinhui Wang & Xianfeng Huang
Pages: 416-421
Published online: 13 Apr 2021
AbstractforThe anti-depressant effects of a novel PDE4 inhibitor derived from resveratrol | Full Text | References | PDF (902.6 KB) | EPUB
  • 3441 Views
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Article
Cytotoxic activity of standardized extracts, a fraction, and individual secondary metabolites from fenugreek seeds against SKOV-3, HeLa and MOLT-4 cell lines
Justyna Stefanowicz-Hajduk, Barbara Król-Kogus, Barbara Sparzak-Stefanowska, Katarzyna Kimel, J. Renata Ochocka & Mirosława Krauze-Baranowska
Pages: 422-435
Published online: 13 Apr 2021
AbstractforCytotoxic activity of standardized extracts, a fraction, and individual secondary metabolites from fenugreek seeds against SKOV-3, HeLa and MOLT-4 cell lines | Full Text | References | PDF (4.4 MB) | EPUB
  • 2999 Views
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Article
HPLC-UV/HRMS methods for the unambiguous detection of adulterations of Ginkgo biloba leaves with Sophora japonica fruits on an extract level
Evangelia Bampali, Stefan Germer, Rudolf Bauer & Žarko Kulić
Pages: 436-441
Published online: 22 Apr 2021
AbstractforHPLC-UV/HRMS methods for the unambiguous detection of adulterations of Ginkgo biloba leaves with Sophora japonica fruits on an extract level | Full Text | References | PDF (1.3 MB) | EPUB
  • 2808 Views
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Article
UPLC-PDA-ESI-QTOF-MS/MS fingerprint of purified flavonoid enriched fraction of Bryophyllum pinnatum; antioxidant properties, anticholinesterase activity and in silico studies
Joyce Oloaigbe Ogidigo, Chioma Assumpta Anosike, Parker Elijah Joshua, Collins U. Ibeji, Daniel Emmanuel Ekpo, Bennett C. Nwanguma & Okwesili Fred Chiletugo Nwodo
Pages: 442-454
Published online: 30 Apr 2021
AbstractforUPLC-PDA-ESI-QTOF-MS/MS fingerprint of purified flavonoid enriched fraction of Bryophyllum pinnatum; antioxidant properties, anticholinesterase activity and in silico studies | Full Text | References | PDF (3.7 MB) | EPUB
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Article
Effects of dacomitinib on the pharmacokinetics of poziotinib in vivo and in vitro
Weiping Ji, Jiquan Shen, Bo Wang, Feifei Chen, Deru Meng, Shuanghu Wang, Dapeng Dai, Yunfang Zhou, Changxiong Wang & Quan Zhou
Pages: 455-462
Published online: 26 Apr 2021
AbstractforEffects of dacomitinib on the pharmacokinetics of poziotinib in vivo and in vitro | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Cryptotanshinone possesses therapeutic effects on ischaemic stroke through regulating STAT5 in a rat model
Feihong Zhu, Hehe Chen, Meifei Xu, Xiajun Zhang, Jing Yu, Yali Pan & Weixin Zhu
Pages: 463-469
Published online: 29 Apr 2021
AbstractforCryptotanshinone possesses therapeutic effects on ischaemic stroke through regulating STAT5 in a rat model | Full Text | References | PDF (1.6 MB) | EPUB
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Review Article

Review
Efficacy and safety of Chinese patent medicine (Kang-ai injection) as an adjuvant in the treatment of patients with hepatocellular carcinoma: a meta-analysis
Chuihua Sun, Fang Dong, Ting Xiao & Wenni Gao
Pages: 470-481
Published online: 27 Apr 2021
AbstractforEfficacy and safety of Chinese patent medicine (Kang-ai injection) as an adjuvant in the treatment of patients with hepatocellular carcinoma: a meta-analysis | Full Text | References | PDF (3.3 MB) | EPUB
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Research Article

Article
The safety and tolerability of alkaloids from Alstonia scholaris leaves in healthy Chinese volunteers: a single-centre, randomized, double-blind, placebo-controlled phase I clinical trial
Zhong-Ping Gou, Yun-Li Zhao, Lin-Ling Zou, Ying Wang, Shi-Qing Shu, Xiao-Hong Zhu, Li Zheng, Qi Shen, Zhu Luo, Jia Miao, Yong-Sheng Wang, Xiao-Dong Luo & Ping Feng
Pages: 482-491
Published online: 26 Apr 2021
AbstractforThe safety and tolerability of alkaloids from Alstonia scholaris leaves in healthy Chinese volunteers: a single-centre, randomized, double-blind, placebo-controlled phase I clinical trial | Full Text | References | PDF (1.2 MB) | EPUB
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Review Article

Review
Green synthesis of metallic nanoparticles using pectin as a reducing agent: a systematic review of the biological activities
Kogilavanee Devasvaran & Vuanghao Lim
Pages: 492-501
Published online: 27 Apr 2021
AbstractforGreen synthesis of metallic nanoparticles using pectin as a reducing agent: a systematic review of the biological activities | Full Text | References | PDF (1.7 MB) | EPUB
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Research Article

Article
Ethanol extract of Gynura bicolour reduces atherosclerosis risk by enhancing antioxidant capacity and reducing adhesion molecule levels
Shu-Ling Hsieh, Jinn-Chyi Wang, Yun-Shan Huang & Chih-Chung Wu
Pages: 502-510
Published online: 27 Apr 2021
AbstractforEthanol extract of Gynura bicolour reduces atherosclerosis risk by enhancing antioxidant capacity and reducing adhesion molecule levels | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Alisol A 24-acetate protects oxygen–glucose deprivation-induced brain microvascular endothelial cells against apoptosis through miR-92a-3p inhibition by targeting the B-cell lymphoma-2 gene
Yangjie Zhou, Wei Wei, Julian Shen, Lu Lu, Taotao Lu, Hong Wang & Xiehua Xue
Pages: 511-522
Published online: 27 Apr 2021
AbstractforAlisol A 24-acetate protects oxygen–glucose deprivation-induced brain microvascular endothelial cells against apoptosis through miR-92a-3p inhibition by targeting the B-cell lymphoma-2 gene | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Quantification of thonningianin a in rat plasma by liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study
Qian Liu, Chunmin Li, Pan Zhao, Jing Li & Zhipeng Deng
Pages: 523-529
Published online: 29 Apr 2021
AbstractforQuantification of thonningianin a in rat plasma by liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Pogostone inhibits the activity of CYP3A4, 2C9, and 2E1 in vitro
Guiying Zhang, Yanping Zhang, Xianjie Ma, Xin Yang, Yuyan Cai & Wenli Yin
Pages: 530-534
Published online: 29 Apr 2021
AbstractforPogostone inhibits the activity of CYP3A4, 2C9, and 2E1 in vitro | Full Text | References | PDF (944.5 KB) | EPUB
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Article
Establishment of an anti-inflammation-based bioassay for the quality control of the 13-component TCM formula (Lianhua Qingwen)
Shuaishuai Chen, Xiaojuan Yang, Ziying Wei, Yanru Zhang, Ying Huang, Zhuo Shi, Ziteng Zhang, Jiabo Wang, Haizhu Zhang, Jianli Ma, Xiaohe Xiao & Ming Niu
Pages: 535-543
Published online: 03 May 2021
AbstractforEstablishment of an anti-inflammation-based bioassay for the quality control of the 13-component TCM formula (Lianhua Qingwen) | Full Text | References | PDF (2.7 MB) | EPUB
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Correction

Correction
Correction
Page: 544
Published online: 26 Apr 2021
CitationforCorrection | Full Text | PDF (144.3 KB) | EPUB
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Research Article

Article
Potential mechanism of Achyranthis bidentatae radix plus semen vaccariae granules in the treatment of diabetes mellitus-induced erectile dysfunction in rats utilizing combined experimental model and network pharmacology
Ji-Sheng Wang, Jun-Long Feng, Heng-Heng Dai, Zi-Long Chen, Xiao Li, Bing-Hao Bao, Sheng Deng, Fan-Chao Meng, Qi Zhao, Hong-Sheng Xu, Bin Wang & Hai-Song Li
Pages: 545-554
Published online: 07 May 2021
AbstractforPotential mechanism of Achyranthis bidentatae radix plus semen vaccariae granules in the treatment of diabetes mellitus-induced erectile dysfunction in rats utilizing combined experimental model and network pharmacology | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Effect of dihydromyricetin on hepatic encephalopathy associated with acute hepatic failure in mice
Long Cheng, Xiaoying Wang, Xueni Ma, Huimei Xu, Yifan Yang & Dekui Zhang
Pages: 555-562
Published online: 13 May 2021
AbstractforEffect of dihydromyricetin on hepatic encephalopathy associated with acute hepatic failure in mice | Full Text | References | PDF (2.5 MB) | EPUB
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Article
Metabolomic assessment of mechanisms underlying anti-renal fibrosis properties of petroleum ether extract from Amygdalus mongolica
Chen Gao, Wan-fu Bai, Hong-bing Zhou, Hai-mei Hao, Ying-chun Bai, Quan-li Liu, Hong Chang & Song-li Shi
Pages: 563-572
Published online: 14 May 2021
AbstractforMetabolomic assessment of mechanisms underlying anti-renal fibrosis properties of petroleum ether extract from Amygdalus mongolica | Full Text | References | PDF (3.4 MB) | EPUB
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Article
Cytotoxic furanosesquiterpenoids and steroids from Ircinia mutans sponges
Fatemeh Heidary Jamebozorgi, Morteza Yousefzadi, Omidreza Firuzi, Melika Nazemi, Somayeh Zare, Jima N. Chandran, Bernd Schneider, Ian T. Baldwin & Amir Reza Jassbi
Pages: 573-581
Published online: 27 May 2021
AbstractforCytotoxic furanosesquiterpenoids and steroids from Ircinia mutans sponges | Full Text | References | PDF (1.4 MB) | EPUB
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Article
Myrtenol improves brain damage and promotes angiogenesis in rats with cerebral infarction by activating the ERK1/2 signalling pathway
Shengming Huang, Zhanguo Tan, Jirui Cai, Zhiping Wang & Yuejun Tian
Pages: 582-591
Published online: 19 May 2021
AbstractforMyrtenol improves brain damage and promotes angiogenesis in rats with cerebral infarction by activating the ERK1/2 signalling pathway | Full Text | References | PDF (2.5 MB) | EPUB
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Article
Xinmai 'an extract enhances the efficacy of sildenafil in the treatment of pulmonary arterial hypertension via inhibiting MAPK signalling pathway
Yaolu Zhu, Yabin Sun, Shichang Zhang, Chuyuan Li, Yiwei Zhao, Boxin Zhao & Guofeng Li
Pages: 592-603
Published online: 19 May 2021
AbstractforXinmai 'an extract enhances the efficacy of sildenafil in the treatment of pulmonary arterial hypertension via inhibiting MAPK signalling pathway | Full Text | References | PDF (3.8 MB) | EPUB
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Article
Mechanism of allergic rhinitis treated by Centipeda minima from different geographic areas
Yanzhuo Jia, Junbo Zou, Yao Wang, Xiaofei Zhang, Yajun Shi, Yulin Liang, Dongyan Guo & Ming Yang
Pages: 604-616
Published online: 19 May 2021
AbstractforMechanism of allergic rhinitis treated by Centipeda minima from different geographic areas | Full Text | References | PDF (3.9 MB) | EPUB
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Article
Lappaol F, an anticancer agent, inhibits YAP via transcriptional and post-translational regulation
Xiao Li, Yi-Ying Lin, Jia-Yi Tan, Kang-Lun Liu, Xiao-Ling Shen, Ying-Jie Hu & Rui-Yi Yang
Pages: 617-626
Published online: 19 May 2021
AbstractforLappaol F, an anticancer agent, inhibits YAP via transcriptional and post-translational regulation | Full Text | References | PDF (3.6 MB) | EPUB
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Article
Selenium-containing protein from selenium-enriched Spirulina platensis antagonizes oxygen glucose deprivation-induced neurotoxicity by inhibiting ROS-mediated oxidative damage through regulating MPTP opening
Xiaojie Song, Lijun Zhang, Xin Hui, Xiangfu Sun, Juntao Yang, Jinlei Wang, Hualian Wu, Xianjun Wang, Zuncheng Zheng, Fengyuan Che & Guojun Wang
Pages: 627-636
Published online: 01 Jun 2021
AbstractforSelenium-containing protein from selenium-enriched Spirulina platensis antagonizes oxygen glucose deprivation-induced neurotoxicity by inhibiting ROS-mediated oxidative damage through regulating MPTP opening | Full Text | References | PDF (2.5 MB) | EPUB
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Article
The influence of Javanese turmeric (Curcuma xanthorrhiza) on the pharmacokinetics of warfarin in rats with single and multiple-dose studies
Taofik Rusdiana, Yanni D. Mardhiani, Norisca A. Putriana, Dolih Gozali, Daisuke Nagano, Takuya Araki & Koujirou Yamamoto
Pages: 637-644
Published online: 01 Jun 2021
AbstractforThe influence of Javanese turmeric (Curcuma xanthorrhiza) on the pharmacokinetics of warfarin in rats with single and multiple-dose studies | Full Text | References | PDF (1.1 MB) | EPUB
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Article
Effect of fermented milk on upper respiratory tract infection in adults who lived in the haze area of Northern China: a randomized clinical trial
Hong Zhang, Junli Miao, Miya Su, Bryan Y. Liu & Zhenmin Liu
Pages: 645-650
Published online: 01 Jun 2021
AbstractforEffect of fermented milk on upper respiratory tract infection in adults who lived in the haze area of Northern China: a randomized clinical trial | Full Text | References | PDF (662.3 KB) | EPUB
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Article
Comparative pharmacokinetic analysis of raw and steamed Panax notoginseng roots in rats by UPLC-MS/MS for simultaneously quantifying seven saponins
Jiajia Dong, Zhenzhen Yin, Lianlin Su, Mengting Yu, Meng Wang, Lin Li, Chunqin Mao & Tulin Lu
Pages: 651-659
Published online: 01 Jun 2021
AbstractforComparative pharmacokinetic analysis of raw and steamed Panax notoginseng roots in rats by UPLC-MS/MS for simultaneously quantifying seven saponins | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Angelica gigas root ameliorates ischaemic stroke-induced brain injury in mice by activating the PI3K/AKT/mTOR and MAPK pathways
Se-Eun Lee, Chiyeon Lim & Suin Cho
Pages: 660-669
Published online: 01 Jun 2021
AbstractforAngelica gigas root ameliorates ischaemic stroke-induced brain injury in mice by activating the PI3K/AKT/mTOR and MAPK pathways | Full Text | References | PDF (3 MB) | EPUB
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Article
Anti-allergic actions of a Chinese patent medicine, huoxiangzhengqi oral liquid, in RBL-2H3 cells and in mice
Jianbin Sun, Sixing Huang, Yao Qin, Ping Zhang, Ziwei Li, Li Zhang, Xin Wang, Ruijun Wu, Shaorong Qin, Jiayong Huo, Kunquan Xiao & Weizao Luo
Pages: 670-680
Published online: 02 Jun 2021
AbstractforAnti-allergic actions of a Chinese patent medicine, huoxiangzhengqi oral liquid, in RBL-2H3 cells and in mice | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Effects of Jian Pi Qing Chang Hua Shi decoction on mucosal injuries in a 2,4,6-trinitrobenzene sulphonic acid-induced inflammatory bowel disease rat model
Huicun Zhang, Na Ta, Hong Shen & Hongbing Wang
Pages: 681-693
Published online: 10 Jun 2021
AbstractforEffects of Jian Pi Qing Chang Hua Shi decoction on mucosal injuries in a 2,4,6-trinitrobenzene sulphonic acid-induced inflammatory bowel disease rat model | Full Text | References | PDF (2.4 MB) | EPUB
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Review Article

Review
Possible therapeutic effects of Nigella sativa and its thymoquinone on COVID-19
Mohammad Reza Khazdair, Shoukouh Ghafari & Mahmood Sadeghi
Pages: 694-701
Published online: 10 Jun 2021
AbstractforPossible therapeutic effects of Nigella sativa and its thymoquinone on COVID-19 | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Extract of Ganoderma sinensis spores induces cell cycle arrest of hepatoma cell via endoplasmic reticulum stress
Weiming Lin, Li Gu, Ling-Yan Zhu, Sha Zhou, Danhong Lian, Yongquan Xu, Limin Zheng, Xin Liu & Lian Li
Pages: 702-712
Published online: 10 Jun 2021
AbstractforExtract of Ganoderma sinensis spores induces cell cycle arrest of hepatoma cell via endoplasmic reticulum stress | Full Text | References | PDF (3 MB) | EPUB
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Article
Verbascoside attenuates experimental varicocele-induced damage to testes and sperm levels through up-regulation of the hypothalamus-pituitary-gonadal (HPG) axis
Letian Han, Shan Xiang, Baohai Rong, Yanchen Liang & Shengtian Zhao
Pages: 713-720
Published online: 19 Jun 2021
AbstractforVerbascoside attenuates experimental varicocele-induced damage to testes and sperm levels through up-regulation of the hypothalamus-pituitary-gonadal (HPG) axis | Full Text | References | PDF (2 MB) | EPUB
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Article
Tocopheryl quinone improves non-alcoholic steatohepatitis (NASH) associated dysmetabolism of glucose and lipids by upregulating the expression of glucagon-like peptide 1 (GLP-1) via restoring the balance of intestinal flora in rats
Tao Sun, Bing Zhang, Qing-jing Ru, Xiao-mei Chen & Bo-dong Lv
Pages: 721-729
Published online: 17 Jun 2021
AbstractforTocopheryl quinone improves non-alcoholic steatohepatitis (NASH) associated dysmetabolism of glucose and lipids by upregulating the expression of glucagon-like peptide 1 (GLP-1) via restoring the balance of intestinal flora in rats | Full Text | References | PDF (2.2 MB) | EPUB
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Short Communication

Brief Report
2,4,6-Trihydroxy-3-geranyl acetophenone suppresses vascular leakage and leukocyte infiltration in lipopolysaccharide-induced endotoxemic mice
Yee Han Chan, Nazmi Firdaus Musa, Yi Joong Chong, Siti Arfah Saat, Faizul Hafiz, Khozirah Shaari, Daud Ahmad Israf & Chau Ling Tham
Pages: 730-738
Published online: 22 Jun 2021
Abstractfor2,4,6-Trihydroxy-3-geranyl acetophenone suppresses vascular leakage and leukocyte infiltration in lipopolysaccharide-induced endotoxemic mice | Full Text | References | PDF (1.7 MB) | EPUB
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Research Article

Article
Simiao Qingwen Baidu decoction inhibits Epstein–Barr virus-induced B lymphoproliferative disease and lytic viral replication
Xianhui Yang, Lingling Liu, Huijuan Zhang, Xiaoxu Sun, Yongbin Yan & Ruiying Ran
Pages: 739-745
Published online: 22 Jun 2021
AbstractforSimiao Qingwen Baidu decoction inhibits Epstein–Barr virus-induced B lymphoproliferative disease and lytic viral replication | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Pharmacokinetics of gallic acid and protocatechuic acid in humans after dosing with Relinqing (RLQ) and the potential for RLQ-perpetrated drug–drug interactions on organic anion transporter (OAT) 1/3
Ziqiang Li, Xi Du, Yanfen Li, Ruihua Wang, Changxiao Liu, Yanguang Cao, Weidang Wu, Jinxia Sun, Baohe Wang & Yuhong Huang
Pages: 746-757
Published online: 18 Jun 2021
AbstractforPharmacokinetics of gallic acid and protocatechuic acid in humans after dosing with Relinqing (RLQ) and the potential for RLQ-perpetrated drug–drug interactions on organic anion transporter (OAT) 1/3 | Full Text | References | PDF (2.5 MB) | EPUB
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Article
Salidroside protects against ventilation-induced lung injury by inhibiting the expression of matrix metalloproteinase-9
Hui Zhang, Wenwen Dong, Siyuan Li, Yunqian Zhang, Zhou Lv, Lu Yang, Lai Jiang, Tao Wu & Yan Wang
Pages: 758-766
Published online: 13 Sep 2021
AbstractforSalidroside protects against ventilation-induced lung injury by inhibiting the expression of matrix metalloproteinase-9 | Full Text | References | PDF (2.6 MB) | EPUB
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Short Communication

Brief Report
A pharmacokinetics–pharmacodynamics study of single-dose total glucosides of paeony capsule on reducing serum total bile acid in hepatic injury rats
Ninghua Jiang, Bohong Zheng, Yihan Feng, Lei Yin, Yuanrong Liu, Lujing Cao, Ning Zheng, Suxiang Wu, Baoyue Ding, Xuan Huang, Jeffrey Wang & Shuyu Zhan
Pages: 767-775
Published online: 21 Jun 2021
AbstractforA pharmacokinetics–pharmacodynamics study of single-dose total glucosides of paeony capsule on reducing serum total bile acid in hepatic injury rats | Full Text | References | PDF (2.1 MB) | EPUB
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Research Article

Article
Traditional medicines and their common uses in central region of Syria: Hama and Homs – an ethnomedicinal survey
Chadi Khatib, Abdulhakim Nattouf & Mohamad Isam Hasan Agha
Pages: 776-786
Published online: 24 Jun 2021
AbstractforTraditional medicines and their common uses in central region of Syria: Hama and Homs – an ethnomedicinal survey | Full Text | References | PDF (1.4 MB) | EPUB
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Article
Therapeutic effects of Sheng Xue Fang in a cyclophosphamide-induced anaemia mouse model
Lu Dou, Xue Gong, Qing Wu & Fangzheng Mou
Pages: 787-796
Published online: 27 Jun 2021
AbstractforTherapeutic effects of Sheng Xue Fang in a cyclophosphamide-induced anaemia mouse model | Full Text | References | PDF (4.7 MB) | EPUB
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Original Paper

Article
Anti-inflammatory effect of Barringtonia angusta methanol extract is mediated by targeting of Src in the NF-κB signalling pathway
Minkyeong Jo, Jongsung Lee, Han Gyung Kim, Jin Kyeong Kim, Haeyeop Kim, Kon Kuk Shin, Tran The Bach, Sang Mi Eum, Jong Sub Lee, Eui Su Choung, Yoonyong Yang, Kyung-Hee Kim, Gi-Ho Sung, Byong Chul Yoo & Jae Youl Cho
Pages: 797-808
Published online: 30 Jun 2021
AbstractforAnti-inflammatory effect of Barringtonia angusta methanol extract is mediated by targeting of Src in the NF-κB signalling pathway | Full Text | References | PDF (2.8 MB) | EPUB
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Research Article

Article
Wutou decoction attenuates rheumatoid arthritis by modulating the Ahr/LOC101928120/SHC1 pathway
Dan Wu, Xi Li, Jun Liu, Can Hu & Jiefang Li
Pages: 809-820
Published online: 29 Jun 2021
AbstractforWutou decoction attenuates rheumatoid arthritis by modulating the Ahr/LOC101928120/SHC1 pathway | Full Text | References | PDF (3.6 MB) | EPUB
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Brief Report

Brief Report
Antithrombotic effects of Huanglian Jiedu decoction in a rat model of ischaemia-reperfusion-induced cerebral stroke
Huan Liu, Xiaoyan Chen, Yanling Liu, Chunjuan Fang & Shaofen Chen
Pages: 821-825
Published online: 01 Jul 2021
AbstractforAntithrombotic effects of Huanglian Jiedu decoction in a rat model of ischaemia-reperfusion-induced cerebral stroke | Full Text | References | PDF (926.8 KB) | EPUB
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Research Article

Article
Pien-Tze-Huang attenuates neuroinflammation in cerebral ischaemia-reperfusion injury in rats through the TLR4/NF-κB/MAPK pathway
Xiaoqin Zhang, Qing Zhang, Lili Huang, Mingzhen Liu, Zaixing Cheng, Yanfang Zheng, Wen Xu, Jinjian Lu, Jian Liu & Mingqing Huang
Pages: 826-837
Published online: 01 Jul 2021
AbstractforPien-Tze-Huang attenuates neuroinflammation in cerebral ischaemia-reperfusion injury in rats through the TLR4/NF-κB/MAPK pathway | Full Text | References | PDF (3.8 MB) | EPUB
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Article
Effects of the methanol fraction of modified Seonghyangjeongki-san water extract on transient ischaemic brain injury in mice
Eun-Jin Kang, Suin Cho, Chiyeon Lim, Byoungho Lee, Young Kyun Kim & Kyoung-Min Kim
Pages: 838-851
Published online: 29 Jun 2021
AbstractforEffects of the methanol fraction of modified Seonghyangjeongki-san water extract on transient ischaemic brain injury in mice | Full Text | References | PDF (3.4 MB) | EPUB
  • 2201 Views
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Article
Thermoregulatory effects of guava leaf extract-menthol toner application for post-exercise use
Titeyut Wongsanao, Wipavadee Leemingsawat, Vipaporn Panapisal & Thanomwong Kritpet
Pages: 852-857
Published online: 01 Jul 2021
AbstractforThermoregulatory effects of guava leaf extract-menthol toner application for post-exercise use | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Schizandrin A ameliorates cognitive functions via modulating microglial polarisation in Alzheimer’s disease mice
Qi Wang, Li Liu, Huibo Guan, Yanyan Zhou & Quan Li
Pages: 858-865
Published online: 02 Jul 2021
AbstractforSchizandrin A ameliorates cognitive functions via modulating microglial polarisation in Alzheimer’s disease mice | Full Text | References | PDF (1.9 MB) | EPUB
  • 2299 Views
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Article
Taxifolin, a novel food, attenuates acute alcohol-induced liver injury in mice through regulating the NF-κB-mediated inflammation and PI3K/Akt signalling pathways
Chuanbo Ding, Yingchun Zhao, Xueyan Chen, Yinan Zheng, Wencong Liu & Xinglong Liu
Pages: 866-877
Published online: 05 Jul 2021
AbstractforTaxifolin, a novel food, attenuates acute alcohol-induced liver injury in mice through regulating the NF-κB-mediated inflammation and PI3K/Akt signalling pathways | Full Text | References | PDF (3.4 MB) | EPUB
  • 2394 Views
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Article
Baicalein inhibits the pharmacokinetics of simvastatin in rats via regulating the activity of CYP3A4
Meng Meng, Xin Li, Xiuwen Zhang & Bin Sun
Pages: 878-881
Published online: 02 Jul 2021
AbstractforBaicalein inhibits the pharmacokinetics of simvastatin in rats via regulating the activity of CYP3A4 | Full Text | References | PDF (564.8 KB) | EPUB
  • 1886 Views
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Article
Study on the pharmacokinetics, tissue distribution and excretion of laurolitsine from Litsea glutinosa in Sprague-Dawley rats
Yin-Feng Tan, Rui-Qi Wang, Wen-Ting Wang, Ying Wu, Ning Ma, Wei-Ying Lu, Yong Zhang & Xiao-Po Zhang
Pages: 882-890
Published online: 03 Jul 2021
AbstractforStudy on the pharmacokinetics, tissue distribution and excretion of laurolitsine from Litsea glutinosa in Sprague-Dawley rats | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Cryptotanshinone enhances the efficacy of Bcr-Abl tyrosine kinase inhibitors via inhibiting STAT3 and eIF4E signalling pathways in chronic myeloid leukaemia
Rubin Cheng, Yilan Huang, Yun Fang, Qirui Wang, Meixiu Yan & Yuqing Ge
Pages: 891-901
Published online: 02 Jul 2021
AbstractforCryptotanshinone enhances the efficacy of Bcr-Abl tyrosine kinase inhibitors via inhibiting STAT3 and eIF4E signalling pathways in chronic myeloid leukaemia | Full Text | References | PDF (3.6 MB) | EPUB
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Article
PTPRM methylation induced by FN1 promotes the development of glioblastoma by activating STAT3 signalling
Jian Song, Di Zhao, Guozhu Sun, Jiankai Yang, Zhongqiang Lv & Baohua Jiao
Pages: 902-909
Published online: 05 Jul 2021
AbstractforPTPRM methylation induced by FN1 promotes the development of glioblastoma by activating STAT3 signalling | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Antidepressant effects of total iridoids of Valeriana jatamansi via the intestinal flora-blood–brain barrier pathway
Li Zhang, Liwen Wang, Li Huang, Yanni Zhao, Hongling Ding, Binglong Li, Lingmiao Wen, Wei Xiong, Yanjun Liu, Tinglan Zhang, Liudai Zhang, Lanlan Wu, Qing Xu, Yuqing Fan, Guihua Wei, Qiaozhi Yin, Yunhui Chen, Tiane Zhang & Zhiyong Yan
Pages: 910-919
Published online: 08 Jul 2021
AbstractforAntidepressant effects of total iridoids of Valeriana jatamansi via the intestinal flora-blood–brain barrier pathway | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Esculin protects against methionine choline-deficient diet-induced non-alcoholic steatohepatitis by regulating the Sirt1/NF-κB p65 pathway
Xi-Ding Yang, Zhuo Chen, Ling Ye, Jing Chen & Yong-Yu Yang
Pages: 920-930
Published online: 09 Jul 2021
AbstractforEsculin protects against methionine choline-deficient diet-induced non-alcoholic steatohepatitis by regulating the Sirt1/NF-κB p65 pathway | Full Text | References | PDF (3.8 MB) | EPUB
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Note

Note
Maculosin, a non-toxic antioxidant compound isolated from Streptomyces sp. KTM18
Babita Paudel, Rukusha Maharjan, Prajwal Rajbhandari, Niraj Aryal, Saefuddin Aziz, Keshab Bhattarai, Bikash Baral, Rajani Malla & Hari Datta Bhattarai
Pages: 931-934
Published online: 08 Jul 2021
AbstractforMaculosin, a non-toxic antioxidant compound isolated from Streptomyces sp. KTM18 | Full Text | References | PDF (707.9 KB) | EPUB
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Research Article

Article
In vitro study on the effect of peucedanol on the activity of cytochrome P450 enzymes
Cun Zhang, Yongwei Li, Changlong Yin, Jie Zheng & Guozhi Liu
Pages: 935-940
Published online: 10 Jul 2021
AbstractforIn vitro study on the effect of peucedanol on the activity of cytochrome P450 enzymes | Full Text | References | PDF (1.1 MB) | EPUB
  • 1387 Views
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Article
Cytotoxicity and molecular docking analysis of racemolactone I, a new sesquiterpene lactone isolated from Inula racemosa
Perwez Alam, Rama Tyagi, Mohammad Abul Farah, Md. Tabish Rehman, Afzal Hussain, Mohamed Fahad AlAjmi, Nasir Ali Siddiqui, Khalid Mashay Al-Anazi, Saima Amin, Mohd. Mujeeb & Showkat R. Mir
Pages: 941-952
Published online: 11 Jul 2021
AbstractforCytotoxicity and molecular docking analysis of racemolactone I, a new sesquiterpene lactone isolated from Inula racemosa | Full Text | References | PDF (2.7 MB) | EPUB
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Review Article

Review
Pseudocedrela kotschyi: a review of ethnomedicinal uses, pharmacology and phytochemistry
Alhassan M. Alhassan, Qamar Uddin Ahmed, Ibrahim Malami & Zainul Amiruddin Zakaria
Pages: 953-961
Published online: 20 Jul 2021
AbstractforPseudocedrela kotschyi: a review of ethnomedicinal uses, pharmacology and phytochemistry | Full Text | References | PDF (1.5 MB) | EPUB
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Research Article

Article
α-Amylase and dipeptidyl peptidase-4 (DPP-4) inhibitory effects of Melicope latifolia bark extracts and identification of bioactive constituents using in vitro and in silico approaches
Alexandra Quek, Nur Kartinee Kassim, Pei Cee Lim, Dai Chuan Tan, Muhammad Alif Mohammad Latif, Amin Ismail, Khozirah Shaari & Khalijah Awang
Pages: 962-971
Published online: 04 Aug 2021
Abstractforα-Amylase and dipeptidyl peptidase-4 (DPP-4) inhibitory effects of Melicope latifolia bark extracts and identification of bioactive constituents using in vitro and in silico approaches | Full Text | References | PDF (2 MB) | EPUB
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Article
Eriodictyol attenuates dextran sodium sulphate-induced colitis in mice by regulating the sonic hedgehog signalling pathway
Ru Wang, Lei Shen, Huimin Li & Hao Peng
Pages: 972-983
Published online: 04 Aug 2021
AbstractforEriodictyol attenuates dextran sodium sulphate-induced colitis in mice by regulating the sonic hedgehog signalling pathway | Full Text | References | PDF (4 MB) | EPUB
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Article
Hepatoprotective effects of Tagetes lucida root extract in carbon tetrachloride-induced hepatotoxicity in Wistar albino rats through amelioration of oxidative stress
Samah Ali El-Newary, Rasha Fouad Ismail, Nermeen Mohammed Shaffie, Saber Fayez Hendawy, Elsayed Omer, Mahgoub Mohammed Ahmed & Wael M. ELsayed
Pages: 984-995
Published online: 04 Aug 2021
AbstractforHepatoprotective effects of Tagetes lucida root extract in carbon tetrachloride-induced hepatotoxicity in Wistar albino rats through amelioration of oxidative stress | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Anti-depressant effects of ethanol extract from Cannabis sativa (hemp) seed in chlorpromazine-induced Drosophila melanogaster depression model
Yejin Ahn, Sung Hee Han, Min Guk Kim, Ki-Bae Hong, Woo Jung Kim, Hyung Joo Suh & Kyungae Jo
Pages: 996-1005
Published online: 06 Aug 2021
AbstractforAnti-depressant effects of ethanol extract from Cannabis sativa (hemp) seed in chlorpromazine-induced Drosophila melanogaster depression model | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Cucumis sativus extract elicits chloride secretion by stimulation of the intestinal TMEM16A ion channel
Tultul Saha, Joydeep Aoun, Paramita Sarkar, Andrea J. Bourdelais, Daniel G. Baden, Normand Leblanc, John M. Hamlyn, Owen M. Woodward & Kazi Mirajul Hoque
Pages: 1006-1013
Published online: 06 Aug 2021
AbstractforCucumis sativus extract elicits chloride secretion by stimulation of the intestinal TMEM16A ion channel | Full Text | References | PDF (1.7 MB) | EPUB
  • 1895 Views
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Article
A metabolomic approach to elucidate the inhibitory effects of baicalin in pulmonary fibrosis
Hong Chang, Hong-yu Meng, Wan-fu Bai & Qing-gang Meng
Pages: 1014-1023
Published online: 06 Aug 2021
AbstractforA metabolomic approach to elucidate the inhibitory effects of baicalin in pulmonary fibrosis | Full Text | References | PDF (2.6 MB) | EPUB
  • 2370 Views
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Article
Curcumin attenuates prostatic hyperplasia caused by inflammation via up-regulation of bone morphogenetic protein and activin membrane-bound inhibitor
Yuhang Liu, Zhaohui Wang, Yu Gan, Xiang Chen, Bo Zhang, Zhi Chen, Peihuan Liu, Bingsheng Li, Feng Ru & Yao He
Pages: 1024-1033
Published online: 06 Aug 2021
AbstractforCurcumin attenuates prostatic hyperplasia caused by inflammation via up-regulation of bone morphogenetic protein and activin membrane-bound inhibitor | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Methyl-β-cyclodextrin suppresses the monocyte-endothelial adhesion triggered by lipopolysaccharide (LPS) or oxidized low-density lipoprotein (oxLDL)
Guo Chen, Yun Zhou, Wendiao Zhang, Ying Qin, Bo Wei, Yanan Sun & Yong Chen
Pages: 1034-1042
Published online: 06 Aug 2021
AbstractforMethyl-β-cyclodextrin suppresses the monocyte-endothelial adhesion triggered by lipopolysaccharide (LPS) or oxidized low-density lipoprotein (oxLDL) | Full Text | References | PDF (2.6 MB) | EPUB
  • 2137 Views
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Article
Huoxue Qianyang Qutan recipe attenuates cardiac fibrosis by inhibiting the NLRP3 inflammasome signalling pathway in obese hypertensive rats
Bo Lu, Jun Xie, Deyu Fu, Xiaozhe Chen, Mingyi Zhao, Mingtai Gui, Lei Yao, Xunjie Zhou & Jianhua Li
Pages: 1043-1055
Published online: 06 Aug 2021
AbstractforHuoxue Qianyang Qutan recipe attenuates cardiac fibrosis by inhibiting the NLRP3 inflammasome signalling pathway in obese hypertensive rats | Full Text | References | PDF (3.7 MB) | EPUB
  • 2269 Views
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Article
Streblus asper attenuates alloxan-induced diabetes in rats and demonstrates antioxidant and cytotoxic effects
M. Oliur Rahman, Ali S. Alqahtani, Sayma Binte Huda, Shah Alam Siddiqui, Omar M. Noman, Fahd Nasr, Md. Abul Hassan & Sheikh Nazrul Islam
Pages: 1056-1062
Published online: 07 Aug 2021
AbstractforStreblus asper attenuates alloxan-induced diabetes in rats and demonstrates antioxidant and cytotoxic effects | Full Text | References | PDF (1.4 MB) | EPUB
  • 1765 Views
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Article
Cerebrospinal fluid proteomics reveal potential protein targets of JiaWeiSiNiSan in preventing chronic psychological stress damage
Han-Zhang Wang, Wu-Long Luo, Ning-Xi Zeng, Hui-Zhen Li, Ling Li, Can Yan & Li-Li Wu
Pages: 1063-1074
Published online: 12 Aug 2021
AbstractforCerebrospinal fluid proteomics reveal potential protein targets of JiaWeiSiNiSan in preventing chronic psychological stress damage | Full Text | References | PDF (2.9 MB) | EPUB
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Article
Kazak faecal microbiota transplantation induces short-chain fatty acids that promote glucagon-like peptide-1 secretion by regulating gut microbiota in db/db mice
Xue Han, Ye Wang, Peipei Zhang, Manli Zhu, Ling Li, Xinmin Mao, Xiaoting Sha & Linlin Li
Pages: 1075-1085
Published online: 15 Aug 2021
AbstractforKazak faecal microbiota transplantation induces short-chain fatty acids that promote glucagon-like peptide-1 secretion by regulating gut microbiota in db/db mice | Full Text | References | PDF (2.3 MB) | EPUB
  • 2687 Views
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Article
Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension
Yousef A. Bin Jardan, Abdul Ahad, Mohammad Raish, Mohd Aftab Alam, Abdullah M. Al-Mohizea & Fahad I. Al-Jenoobi
Pages: 1086-1095
Published online: 15 Aug 2021
AbstractforEffects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension | Full Text | References | PDF (3.8 MB) | EPUB
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Retracted Article

Article
RETRACTED ARTICLE: 18β-Glycyrrhetinic acid inhibits the apoptosis of cells infected with rotavirus SA11 via the Fas/FasL pathway
Xiaoyan Wang, Fang Xie, Xiaofeng Zhou, Ting Chen, Ye Xue & Wei Wang
Pages: 1096-1103
Published online: 19 Aug 2021
AbstractforRETRACTED ARTICLE: 18β-Glycyrrhetinic acid inhibits the apoptosis of cells infected with rotavirus SA11 via the Fas/FasL pathway | PDF (3.1 MB)
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Research Article

Article
Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway
Zhuo Feng, Changyuan Wang, Yue Jin, Qiang Meng, Jingjing Wu & Huijun Sun
Pages: 1104-1114
Published online: 17 Aug 2021
AbstractforKaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway | Full Text | References | PDF (2.6 MB) | EPUB
  • 3757 Views
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Article
Saponins from Panax japonicus attenuate cognitive impairment in ageing rats through regulating microglial polarisation and autophagy
Xue-Jiao Pi, Qing-Qing Zhao, Jin-Xin Wang, Xu-Lan Zhang, Ding Yuan, Shan-Shan Hu, Yu-Min He, Chang-Cheng Zhang, Zhi-Yong Zhou & Ting Wang
Pages: 1115-1123
Published online: 17 Aug 2021
AbstractforSaponins from Panax japonicus attenuate cognitive impairment in ageing rats through regulating microglial polarisation and autophagy | Full Text | References | PDF (2.7 MB) | EPUB
  • 2086 Views
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Article
Anticancer effect of myristicin on hepatic carcinoma and related molecular mechanism
Hailan Bao & Qi Muge
Pages: 1124-1130
Published online: 19 Aug 2021
AbstractforAnticancer effect of myristicin on hepatic carcinoma and related molecular mechanism | Full Text | References | PDF (2.6 MB) | EPUB
  • 1900 Views
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Article
Evaluation of herb-drug interaction of ambrisentan with shikonin based on UPLC-MS/MS
Tian Lan, Ping Fang, Xuemei Ye, Xia Lan & Ren-ai Xu
Pages: 1131-1136
Published online: 19 Aug 2021
AbstractforEvaluation of herb-drug interaction of ambrisentan with shikonin based on UPLC-MS/MS | Full Text | References | PDF (1.4 MB) | EPUB
  • 1805 Views
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Article
Bioadhesive hydrogel comprising bilirubin/β-cyclodextrin inclusion complexes promote diabetic wound healing
Qing Yao, Yannan Shi, Xing Xia, Yingying Tang, Xue Jiang, Ya-Wen Zheng, Hailin Zhang, Ruijie Chen & Longfa Kou
Pages: 1137-1147
Published online: 23 Aug 2021
AbstractforBioadhesive hydrogel comprising bilirubin/β-cyclodextrin inclusion complexes promote diabetic wound healing | Full Text | References | PDF (4.2 MB) | EPUB
  • 3213 Views
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Article
Yiguanjian decoction inhibits macrophage M1 polarization and attenuates hepatic fibrosis induced by CCl4/2-AAF
Ying Xu, Wen Xu, Wei Liu, Gaofeng Chen, Shili Jiang, Jiamei Chen, Xun Jian, Hua Zhang, Ping Liu & Yongping Mu
Pages: 1148-1158
Published online: 23 Aug 2021
AbstractforYiguanjian decoction inhibits macrophage M1 polarization and attenuates hepatic fibrosis induced by CCl4/2-AAF | Full Text | References | PDF (3.1 MB) | EPUB
  • 3667 Views
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Review Article

Review
The beneficial effects of Ganoderma lucidum on cardiovascular and metabolic disease risk
Sze Wa Chan, Brian Tomlinson, Paul Chan & Christopher Wai Kei Lam
Pages: 1159-1169
Published online: 31 Aug 2021
AbstractforThe beneficial effects of Ganoderma lucidum on cardiovascular and metabolic disease risk | Full Text | References | PDF (1.5 MB) | EPUB
  • 8247 Views
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Research Article

Article
Hepatoprotective effect and metabonomics studies of radix gentianae in rats with acute liver injury
Shizhao Xu, Fanli Kong, Zhengwu Sun, Yalin Xi, Fei Qi & Jianzhi Sun
Pages: 1170-1178
Published online: 31 Aug 2021
AbstractforHepatoprotective effect and metabonomics studies of radix gentianae in rats with acute liver injury | Full Text | References | PDF (2.6 MB) | EPUB
  • 1964 Views
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Article
Long-term toxicological studies on the Chinese medicine 2036 Specialty-Qiangxin recipe in rats
Andong Zhao, Yi Yang, Xiaohua Pan, Manhon Chung, Sa Cai & Yu Pan
Pages: 1179-1188
Published online: 31 Aug 2021
AbstractforLong-term toxicological studies on the Chinese medicine 2036 Specialty-Qiangxin recipe in rats | Full Text | References | PDF (2.3 MB) | EPUB
  • 1982 Views
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Article
Network pharmacology-based analysis in determining the mechanisms of Huoxin pill in protecting against myocardial infarction
Jia He, Da Wo, En Ma, Qing Wang, Jinxiao Chen, Jun Peng, Weidong Zhu & Dan-ni Ren
Pages: 1189-1200
Published online: 07 Sep 2021
AbstractforNetwork pharmacology-based analysis in determining the mechanisms of Huoxin pill in protecting against myocardial infarction | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Gynura procumbens ethanol extract improves vascular dysfunction by suppressing inflammation in postmenopausal rats fed a high-fat diet
Khuzaidatul Azidah Ahmad Nazri, Qodriyah Haji Mohd Saad, Norsyahida Mohd Fauzi, Fhataheya Buang, Ibrahim Jantan & Zakiah Jubri
Pages: 1201-1213
Published online: 07 Sep 2021
AbstractforGynura procumbens ethanol extract improves vascular dysfunction by suppressing inflammation in postmenopausal rats fed a high-fat diet | Full Text | References | PDF (2.5 MB) | EPUB
  • 1683 Views
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Article
Modified BuShenYiQi formula alleviates experimental allergic asthma in mice by negative regulation of type 2 innate lymphoid cells and CD4+ type 9 helper T cells and the VIP–VPAC2 signalling pathway
Muhua Huang, Jinfeng Wu & Jingcheng Dong
Pages: 1214-1230
Published online: 07 Sep 2021
AbstractforModified BuShenYiQi formula alleviates experimental allergic asthma in mice by negative regulation of type 2 innate lymphoid cells and CD4+ type 9 helper T cells and the VIP–VPAC2 signalling pathway | Full Text | References | PDF (5 MB) | EPUB
  • 2094 Views
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Article
Edaravone prevents high glucose-induced injury in retinal Müller cells through thioredoxin1 and the PGC-1α/NRF1/TFAM pathway
Juanping Yin & Xinke Chen
Pages: 1231-1242
Published online: 10 Sep 2021
AbstractforEdaravone prevents high glucose-induced injury in retinal Müller cells through thioredoxin1 and the PGC-1α/NRF1/TFAM pathway | Full Text | References | PDF (3.1 MB) | EPUB
  • 2053 Views
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Article
Effects of icariin on the fracture healing in young and old rats and its mechanism
Xiaoyun Zhang, Yueping Chen, Chi Zhang, Xuan Zhang, Tian Xia, Jie Han, Shilei Song, Canhong Xu & Feng Chen
Pages: 1243-1253
Published online: 12 Sep 2021
AbstractforEffects of icariin on the fracture healing in young and old rats and its mechanism | Full Text | References | PDF (4.2 MB) | EPUB
  • 2267 Views
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Article
Pharmacokinetic study on the interaction between pachymic acid and bavachin and its potential mechanism
Jie Zhang, Lu Liu, Hong Li & Bin Zhang
Pages: 1254-1257
Published online: 13 Sep 2021
AbstractforPharmacokinetic study on the interaction between pachymic acid and bavachin and its potential mechanism | Full Text | References | PDF (685.3 KB) | EPUB
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Review

Review
Aidi injection as adjunctive treatment to gemcitabine-based chemotherapy for advanced non-small cell lung cancer: a systematic review and meta-analysis
Sitong Guo, Yan Li, Henghai Su, Mingyu Meng, Jiaxi Xi, Guangyan Mo & Xiaoyu Chen
Pages: 1258-1273
Published online: 19 Sep 2021
AbstractforAidi injection as adjunctive treatment to gemcitabine-based chemotherapy for advanced non-small cell lung cancer: a systematic review and meta-analysis | Full Text | References | PDF (3.1 MB) | EPUB
  • 2178 Views
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Review Article

Review
Efficiency and safety of desloratadine in combination with compound glycyrrhizin in the treatment of chronic urticaria: a meta-analysis and systematic review of randomised controlled trials
Yulong Wen, Yidan Tang, Miaoyue Li & Yu Lai
Pages: 1274-1283
Published online: 13 Sep 2021
AbstractforEfficiency and safety of desloratadine in combination with compound glycyrrhizin in the treatment of chronic urticaria: a meta-analysis and systematic review of randomised controlled trials | Full Text | References | PDF (2.1 MB) | EPUB
  • 2117 Views
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Research Article

Article
Rosmarinic acid ameliorates acetaminophen-induced acute liver injury in mice via RACK1/TNF-α mediated antioxidant effect
Yang Yu, Yao Wu, Hao-zheng Yan, Zi-ru Xia, Wen Wen, Dan-yang Liu & Li-hong Wan
Pages: 1284-1291
Published online: 13 Sep 2021
AbstractforRosmarinic acid ameliorates acetaminophen-induced acute liver injury in mice via RACK1/TNF-α mediated antioxidant effect | Full Text | References | PDF (1.9 MB) | EPUB
  • 1985 Views
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Article
Yang-Yin-Jie-Du decoction overcomes gefitinib resistance in non-small cell lung cancer via down-regulation of the PI3K/Akt signalling pathway
Shu-yi Chen, Gao-chen-xi Zhang & Qi-jin Shu
Pages: 1292-1302
Published online: 20 Sep 2021
AbstractforYang-Yin-Jie-Du decoction overcomes gefitinib resistance in non-small cell lung cancer via down-regulation of the PI3K/Akt signalling pathway | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway
Yue Cui, Yongqiang Wang & Gang Liu
Pages: 1303-1311
Published online: 04 Oct 2021
AbstractforEpigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway | Full Text | References | PDF (2 MB) | EPUB
  • 1839 Views
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Article
SIRT 3 was involved in Lycium barbarum seed oil protection testis from oxidative stress: in vitro and in vivo analyses
Zhang-Jie Yang, Yu-Xin Wang, Shuai Zhao, Na Hu, Dong-Mei Chen & Hui-Ming Ma
Pages: 1312-1323
Published online: 26 Sep 2021
AbstractforSIRT 3 was involved in Lycium barbarum seed oil protection testis from oxidative stress: in vitro and in vivo analyses | Full Text | References | PDF (3.3 MB) | EPUB
  • 1955 Views
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Article
Isovitexin alleviates acute gouty arthritis in rats by inhibiting inflammation via the TLR4/MyD88/NF-κB pathway
Xiujiang Sun, Peng Li, Xiaoyi Qu & Wenguang Liu
Pages: 1324-1331
Published online: 28 Sep 2021
AbstractforIsovitexin alleviates acute gouty arthritis in rats by inhibiting inflammation via the TLR4/MyD88/NF-κB pathway | Full Text | References | PDF (1.6 MB) | EPUB
  • 2466 Views
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Article
Pharmacokinetic study of Tangwang Mingmu granule for the management of diabetic retinopathy based on network pharmacology
Yucheng Wang, Beibei Xue, Xiaoli Wang, Qilong Wang, Erwei Liu & Xiaopeng Chen
Pages: 1332-1348
Published online: 30 Sep 2021
AbstractforPharmacokinetic study of Tangwang Mingmu granule for the management of diabetic retinopathy based on network pharmacology | Full Text | References | PDF (4 MB) | EPUB
  • 2728 Views
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Retracted Article

Article
RETRACTED ARTICLE: Pristimerin inhibits neuronal inflammation and protects cognitive function in mice with sepsis-induced brain injuries by regulating PI3K/Akt signalling
Weimin Xue, Yaqiang Li & Mei Zhang
Pages: 1349-1356
Published online: 30 Sep 2021
AbstractforRETRACTED ARTICLE: Pristimerin inhibits neuronal inflammation and protects cognitive function in mice with sepsis-induced brain injuries by regulating PI3K/Akt signalling | PDF (2.1 MB)
  • 1828 Views
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Research Article

Article
Jiang Zhi Granule protects immunological barrier of intestinal mucosa in rats with non-alcoholic steatohepatitis
Xiao Yu, Haiyan Zhang, Jielu Pan, Lu Zou, Ling Tang, Hongyu Miao, Peiyong Zheng & Lianjun Xing
Pages: 1357-1366
Published online: 16 Dec 2021
AbstractforJiang Zhi Granule protects immunological barrier of intestinal mucosa in rats with non-alcoholic steatohepatitis | Full Text | References | PDF (2.8 MB) | EPUB
  • 1686 Views
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Article
Ginsenoside Rb1 attenuates age-associated vascular impairment by modulating the Gas6 pathway
Shiye Ke, Lin Wu, Min Wang, Dinghui Liu, Guangyao Shi, Jieming Zhu & Xiaoxian Qian
Pages: 1367-1375
Published online: 09 Oct 2021
AbstractforGinsenoside Rb1 attenuates age-associated vascular impairment by modulating the Gas6 pathway | Full Text | References | PDF (2 MB) | EPUB
  • 1878 Views
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Article
Chrysanthemi Flos extract alleviated acetaminophen-induced rat liver injury via inhibiting oxidative stress and apoptosis based on network pharmacology analysis
Yunfeng Zhou, Chunli Wang, Jiejian Kou, Minghui Wang, Xuli Rong, Xiaohui Pu, Xinmei Xie, Guang Han & Xiaobin Pang
Pages: 1376-1385
Published online: 09 Oct 2021
AbstractforChrysanthemi Flos extract alleviated acetaminophen-induced rat liver injury via inhibiting oxidative stress and apoptosis based on network pharmacology analysis | Full Text | References | PDF (3.1 MB) | EPUB
  • 2841 Views
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Article
Genistein alleviates H2O2-induced senescence of human umbilical vein endothelial cells via regulating the TXNIP/NLRP3 axis
Guihua Wu, Siming Li, Guangjin Qu, Jiajia Hua, Jing Zong, Xiaofeng Li & Fanghui Xu
Pages: 1386-1399
Published online: 18 Oct 2021
AbstractforGenistein alleviates H2O2-induced senescence of human umbilical vein endothelial cells via regulating the TXNIP/NLRP3 axis | Full Text | References | PDF (4.2 MB) | EPUB
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Article
Erzhi pills ameliorate cognitive dysfunction and alter proteomic hippocampus profiles induced by d-galactose and Aβ1–40 injection in ovariectomized Alzheimer’s disease model rats
Yongyan Xie, Bo Yan, Min Hou, Maofu Zhou, Chao Liu, Mengsheng Sun, Kun He, Cong Fang, Yaohui Chen & Liping Huang
Pages: 1400-1412
Published online: 21 Oct 2021
AbstractforErzhi pills ameliorate cognitive dysfunction and alter proteomic hippocampus profiles induced by d-galactose and Aβ1–40 injection in ovariectomized Alzheimer’s disease model rats | Full Text | References | PDF (3.3 MB) | EPUB
  • 2403 Views
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Article
Simultaneous measurement of tadehaginoside and its principal metabolite in rats by HPLC–MS/MS and its application in pharmacokinetics and tissue distribution study
Cai-Yun Zhang, Ya-Ting Lu, Yin-Feng Tan, Qi-Bing Liu, Lin Dong, Ning Ma, Wei-Ying Lu, Zhi-Heng Su & Xiao-Po Zhang
Pages: 1413-1422
Published online: 24 Oct 2021
AbstractforSimultaneous measurement of tadehaginoside and its principal metabolite in rats by HPLC–MS/MS and its application in pharmacokinetics and tissue distribution study | Full Text | References | PDF (1.9 MB) | EPUB
  • 1251 Views
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Article
Huaiqihuang (HQH) granule alleviates cyclophosphamide-induced nephrotoxicity via suppressing the MAPK/NF-κB pathway and NLRP3 inflammasome activation
Yueming Zhang, Jian Chang, Huan Gao, Xiaoyu Qu, Jinghui Zhai, Lina Tao, Jingmeng Sun & Yanqing Song
Pages: 1423-1429
Published online: 25 Oct 2021
AbstractforHuaiqihuang (HQH) granule alleviates cyclophosphamide-induced nephrotoxicity via suppressing the MAPK/NF-κB pathway and NLRP3 inflammasome activation | Full Text | References | PDF (2.1 MB) | EPUB
  • 1957 Views
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Article
Clinacanthus nutans attenuates atherosclerosis progression in rats with type 2 diabetes by reducing vascular oxidative stress and inflammation
Ahmad Khusairi Azemi, Siti Safiah Mokhtar, Sharifah Emilia Tuan Sharif & Aida Hanum Ghulam Rasool
Pages: 1430-1438
Published online: 25 Oct 2021
AbstractforClinacanthus nutans attenuates atherosclerosis progression in rats with type 2 diabetes by reducing vascular oxidative stress and inflammation | Full Text | References | PDF (1.5 MB) | EPUB
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Article
Qingluoyin granules protect against adjuvant-induced arthritis in rats via downregulating the CXCL12/CXCR4-NF-κB signalling pathway
Min Si, Zheng Ma, Jie Zhang, Xinwei Li, Rui Li, Chao Wang, Huiyu Jia & Shengyong Luo
Pages: 1439-1449
Published online: 25 Oct 2021
AbstractforQingluoyin granules protect against adjuvant-induced arthritis in rats via downregulating the CXCL12/CXCR4-NF-κB signalling pathway | Full Text | References | PDF (3.4 MB) | EPUB
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Article
Wei Chang An pill regulates gastrointestinal motility in a bidirectional manner
Sitong Jia, Lijuan Chai, Jing Zhang, Min Zhang, Lin Li, Yaxin Qi, Yafen Pang, Xi Chen, Nana Fan, Lin Wang, Yujing Wang, Jixiang Song, Yingjie Sun, Yi Wang, Lin Miao & Han Zhang
Pages: 1450-1461
Published online: 28 Oct 2021
AbstractforWei Chang An pill regulates gastrointestinal motility in a bidirectional manner | Full Text | References | PDF (3.6 MB) | EPUB
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Article
Polyphenol containing Sargassum horneri attenuated Th2 differentiation in splenocytes of ovalbumin-sensitised mice: involvement of the transcription factors GATA3/STAT5/NLRP3 in Th2 polarization
Kalahe Hewage Iresha Nadeeka Madushani Herath, Jinhee Cho, Hyo Jin Kim, Duong Thi Thuy Dinh, Hyun-Soo Kim, Ginnae Ahn, You-Jin Jeon & Youngheun Jee
Pages: 1462-1470
Published online: 02 Nov 2021
AbstractforPolyphenol containing Sargassum horneri attenuated Th2 differentiation in splenocytes of ovalbumin-sensitised mice: involvement of the transcription factors GATA3/STAT5/NLRP3 in Th2 polarization | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Icariin inhibits the expression of IL-1β, IL-6 and TNF-α induced by OGD/R through the IRE1/XBP1s pathway in microglia
Zhen-Tao Mo, Jie Zheng & Yu-ling Liao
Pages: 1471-1477
Published online: 28 Oct 2021
AbstractforIcariin inhibits the expression of IL-1β, IL-6 and TNF-α induced by OGD/R through the IRE1/XBP1s pathway in microglia | Full Text | References | PDF (1.5 MB) | EPUB
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Review Article

Review
Saikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics
Piao Zhou, Wei Shi, Xiao-Yan He, Quan-Yu Du, Fei Wang & Jing Guo
Pages: 1478-1487
Published online: 29 Oct 2021
AbstractforSaikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics | Full Text | References | PDF (970.3 KB) | EPUB
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Research Article

Article
Nanoencapsulation of sulforaphane in broccoli membrane vesicles and their in vitro antiproliferative activity
Lucía Yepes-Molina & Micaela Carvajal
Pages: 1488-1502
Published online: 29 Oct 2021
AbstractforNanoencapsulation of sulforaphane in broccoli membrane vesicles and their in vitro antiproliferative activity | Full Text | References | PDF (3.2 MB) | EPUB
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The potential of Zishen Yutai pills to facilitate endometrial recovery and restore fertility after induced abortion in rats
Mianmian Li, Na Ning, Yu Liu, Xiaohui Li, Qiaojuan Mei, Jiebin Zhou, Qiuling Huang, Wenpei Xiang, Ling Zhang & Xiaoyan Xu
Pages: 1503-1514
Published online: 28 Oct 2021
AbstractforThe potential of Zishen Yutai pills to facilitate endometrial recovery and restore fertility after induced abortion in rats | Full Text | References | PDF (4.6 MB) | EPUB
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Article
Neochlorogenic acid: an anti-HIV active compound identified by screening of Cortex Mori [Morus Alba L. (Moraceae)]
Jing Li, Lu Dou, Shuangfeng Chen, Honghao Zhou & Fangzheng Mou
Pages: 1515-1525
Published online: 29 Oct 2021
AbstractforNeochlorogenic acid: an anti-HIV active compound identified by screening of Cortex Mori [Morus Alba L. (Moraceae)] | Full Text | References | PDF (2.6 MB) | EPUB
  • 1555 Views
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Article
The pharmacokinetic study on the interaction between nobiletin and anemarsaponin BII in vivo and in vitro
Jie Zhang, Meiling Fan, Xia Yu & Bin Zhang
Pages: 1526-1530
Published online: 02 Nov 2021
AbstractforThe pharmacokinetic study on the interaction between nobiletin and anemarsaponin BII in vivo and in vitro | Full Text | References | PDF (802.1 KB) | EPUB
  • 1285 Views
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Article
Astragalus polysacharin inhibits hepatocellular carcinoma-like phenotypes in a murine HCC model through repression of M2 polarization of tumour-associated macrophages
Chun Li, Xin-You Pan, Mingyun Ma, Jun Zhao, Fengda Zhao & Ya-Ping Lv
Pages: 1531-1537
Published online: 02 Nov 2021
AbstractforAstragalus polysacharin inhibits hepatocellular carcinoma-like phenotypes in a murine HCC model through repression of M2 polarization of tumour-associated macrophages | Full Text | References | PDF (2 MB) | EPUB
  • 2041 Views
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Salidroside orchestrates metabolic reprogramming by regulating the Hif-1α signalling pathway in acute mountain sickness
Xiaoning Yan, Jie Liu, Meixia Zhu, Lirong Liu, Yijun Chen, Yinhuan Zhang, Menghan Feng, Zhixin Jia & Hongbin Xiao
Pages: 1538-1548
Published online: 05 Nov 2021
AbstractforSalidroside orchestrates metabolic reprogramming by regulating the Hif-1α signalling pathway in acute mountain sickness | Full Text | References | PDF (3.1 MB) | EPUB
  • 2037 Views
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Pharmacokinetic interaction between rhynchopylline and pellodendrine via CYP450 enzymes and P-gp
Qingzhen Meng, Yongheng Cheng & Cui Zhou
Pages: 1549-1553
Published online: 10 Nov 2021
AbstractforPharmacokinetic interaction between rhynchopylline and pellodendrine via CYP450 enzymes and P-gp | Full Text | References | PDF (858.8 KB) | EPUB
  • 1193 Views
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Article
Aucubin slows the development of osteoporosis by inhibiting osteoclast differentiation via the nuclear factor erythroid 2-related factor 2-mediated antioxidation pathway
Yongfeng Zhang, Xin Liu, Yangyang Li, Minkai Song, Yutong Li, Anhui Yang, Yaqin Zhang, Di Wang & Min Hu
Pages: 1554-1563
Published online: 10 Nov 2021
AbstractforAucubin slows the development of osteoporosis by inhibiting osteoclast differentiation via the nuclear factor erythroid 2-related factor 2-mediated antioxidation pathway | Full Text | References | PDF (3.9 MB) | EPUB
  • 2614 Views
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Article
Gambogic amide inhibits angiogenesis by suppressing VEGF/VEGFR2 in endothelial cells in a TrkA-independent manner
Tongtong Sui, Bojun Qiu, Jiaorong Qu, Yuxin Wang, Kunnian Ran, Wei Han & Xiaozhong Peng
Pages: 1564-1573
Published online: 12 Nov 2021
AbstractforGambogic amide inhibits angiogenesis by suppressing VEGF/VEGFR2 in endothelial cells in a TrkA-independent manner | Full Text | References | PDF (2.4 MB) | EPUB
  • 1425 Views
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Article
In vitro-in vivo availability of metformin hydrochloride-PLGA nanoparticles in diabetic rats in a periodontal disease experimental model
Aline de Sousa Barbosa Freitas Pereira, Maria Laura de Souza Lima, Arnobio Antonio da Silva-Junior, Emanuell dos Santos Silva, Raimundo Fernandes de Araújo Júnior, Agnes Andrade Martins, Jovelina Samara Ferreira Alves, Artur de Santana Oliveira, Leandro De Santis Ferreira, Emily Cintia Tossi de Araújo Costa, Gerlane Coelho Bernardo Guerra, Caroline Addison Carvalho Xavier de Medeiros, Gerly A. C. Brito, Renata Ferreira de Carvalho Leitao & Aurigena Antunes de Araújo
Pages: 1574-1582
Published online: 22 Nov 2021
AbstractforIn vitro-in vivo availability of metformin hydrochloride-PLGA nanoparticles in diabetic rats in a periodontal disease experimental model | Full Text | References | PDF (1.9 MB) | EPUB
  • 2380 Views
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Rapid Communication

Brief Report
Compound Danshen Dripping Pill inhibits high altitude-induced hypoxic damage by suppressing oxidative stress and inflammatory responses
Yunhui Hu, Jia Sun, Tongxing Wang, Hairong Wang, Chunlai Zhao, Wenjia Wang, Kaijing Yan, Xijun Yan & He Sun
Pages: 1583-1591
Published online: 22 Nov 2021
AbstractforCompound Danshen Dripping Pill inhibits high altitude-induced hypoxic damage by suppressing oxidative stress and inflammatory responses | Full Text | References | PDF (2.3 MB) | EPUB
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Research Article

Article
Development of a novel anti-liver fibrosis formula with luteolin, licochalcone A, aloe-emodin and acacetin by network pharmacology and transcriptomics analysis
Yuan Zhou, Rong Wu, Fei-fei Cai, Wen-Jun Zhou, Yi-Yu Lu, Hui Zhang, Qi-Long Chen, Ming-Yu Sun & Shi-Bing Su
Pages: 1592-1604
Published online: 22 Nov 2021
AbstractforDevelopment of a novel anti-liver fibrosis formula with luteolin, licochalcone A, aloe-emodin and acacetin by network pharmacology and transcriptomics analysis | Full Text | References | PDF (3.6 MB) | EPUB
  • 3566 Views
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Article
Protective effect of Qingre Huoxue decoction against myocardial infarction via PI3K/Akt autophagy pathway based on UPLC-MS, network pharmacology, and in vivo evidence
Zheng Jin, Wenbo Zhang, Yuan Luo, Xiushen Li, Lijin Qing, Qiang Zuo, Junfeng Fang & Wei Wu
Pages: 1605-1616
Published online: 24 Nov 2021
AbstractforProtective effect of Qingre Huoxue decoction against myocardial infarction via PI3K/Akt autophagy pathway based on UPLC-MS, network pharmacology, and in vivo evidence | Full Text | References | PDF (3.9 MB) | EPUB
  • 2130 Views
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Article
Pharmacokinetic study on the interaction between succinic acid and irbesartan in rats and its potential mechanism
Yongpeng Wang, Ruping Rui, Xiaoyan Zhang & Bin Sun
Pages: 1617-1620
Published online: 24 Nov 2021
AbstractforPharmacokinetic study on the interaction between succinic acid and irbesartan in rats and its potential mechanism | Full Text | References | PDF (550.4 KB) | EPUB
  • 1117 Views
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