Bioengineered, Volume 13, Issue 4 (2022)

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Bioengineered, Volume 13, Issue 4 (2022)

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Research paper

Article
N6-methyladenosine methyltransferase WTAP-stabilized FOXD2-AS1 promotes the osteosarcoma progression through m6A/FOXM1 axis
Zhipeng Ren, Yongcheng Hu, Jie Sun, Yuxiang Kang, Guishi Li & Hejun Zhao
Pages: 7963-7973
Published online: 31 Mar 2022
AbstractforN6-methyladenosine methyltransferase WTAP-stabilized FOXD2-AS1 promotes the osteosarcoma progression through m6A/FOXM1 axis | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Research Paper

Article
GATA binding protein 5-mediated transcriptional activation of transmembrane protein 100 suppresses cell proliferation, migration and epithelial-to-mesenchymal transition in prostate cancer DU145 cells
Jiaolin Liu, Fanlu Lin, Xin Wang, Chaopeng Li & Qiangyuan Qi
Pages: 7972-7983
Published online: 31 Mar 2022
AbstractforGATA binding protein 5-mediated transcriptional activation of transmembrane protein 100 suppresses cell proliferation, migration and epithelial-to-mesenchymal transition in prostate cancer DU145 cells | Full Text | References | PDF (3 MB) | EPUB
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Open Access
Article
Magnesium isoglycyrrhizinate suppresses bladder cancer progression by modulating the miR-26b/Nox4 axis
Zhihao Yuan, Guancheng Guo, Guifang Sun, Qi Li, Lihui Wang & Baoping Qiao
Pages: 7986-7999
Published online: 16 Mar 2022
AbstractforMagnesium isoglycyrrhizinate suppresses bladder cancer progression by modulating the miR-26b/Nox4 axis | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 1362 Views
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Open Access
Article
UBE2B promotes ovarian cancer growth via promoting RAD18 mediated ZMYM2 monoubiquitination and stabilization
Xi Zeng, Wen Zheng, Yuting Sheng & Hongwei Ma
Pages: 8000-8012
Published online: 22 Mar 2022
AbstractforUBE2B promotes ovarian cancer growth via promoting RAD18 mediated ZMYM2 monoubiquitination and stabilization | Full Text | References | PDF (3.8 MB) | EPUB
  • 1703 Views
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Open Access
Article
The effect and mechanism of miR-30e-5p targeting SNAI1 to regulate epithelial-mesenchymal transition on pancreatic cancer
Ziyu Liang, Shaomei Tang, Rongquan He, Wei Luo, Shanyu Qin & Haixing Jiang
Pages: 8013-8028
Published online: 18 Mar 2022
AbstractforThe effect and mechanism of miR-30e-5p targeting SNAI1 to regulate epithelial-mesenchymal transition on pancreatic cancer | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
  • 1269 Views
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Open Access
Article
Study on the pro-inflammatory mechanism of the HuD antibody in promoting M1 polarization and paraneoplastic neurological syndrome occurrence
Liang Yin, Wen-Ling Yuan, Ke Wu, Li-Na Zhang & Qian-Qian Li
Pages: 8029-8037
Published online: 16 Mar 2022
AbstractforStudy on the pro-inflammatory mechanism of the HuD antibody in promoting M1 polarization and paraneoplastic neurological syndrome occurrence | Full Text | References | PDF (1 MB) | EPUB
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Open Access
Article
Fat mass and obesity associated (FTO)-mediated N6-methyladenosine modification of Krüppel-like factor 3 (KLF3) promotes osteosarcoma progression
Hong-Jian Shan, Wen-Xiang Gu, Gang Duan & Hong-Liang Chen
Pages: 8038-8050
Published online: 21 Mar 2022
AbstractforFat mass and obesity associated (FTO)-mediated N6-methyladenosine modification of Krüppel-like factor 3 (KLF3) promotes osteosarcoma progression | Full Text | References | PDF (3 MB) | EPUB | Supplemental
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Open Access
Article
Knockdown of long noncoding RNA HUMT inhibits the proliferation and metastasis by regulating miR-455-5p/LRP4 axis in hepatocellular carcinoma
Xianzhi Zou, Peng Sun, Hui Xie, Lu Fan, Kun Ding, Jiyang Wang & Yang Li
Pages: 8051-8063
Published online: 16 Mar 2022
AbstractforKnockdown of long noncoding RNA HUMT inhibits the proliferation and metastasis by regulating miR-455-5p/LRP4 axis in hepatocellular carcinoma | Full Text | References | PDF (4 MB) | EPUB
  • 1409 Views
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Open Access
Article
RAB26 contributes to the progression of non-small cell lung cancer after being transcriptionally activated by SMAD3
Haixia Ren, Bo Yang, Mingjiang Li, Chunling Lu & Xiaoping Li
Pages: 8064-8075
Published online: 16 Mar 2022
AbstractforRAB26 contributes to the progression of non-small cell lung cancer after being transcriptionally activated by SMAD3 | Full Text | References | PDF (3.8 MB) | EPUB
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Article
Ribosomal protein L5 (RPL5)/ E2F transcription factor 1 (E2F1) signaling suppresses breast cancer progression via regulating endoplasmic reticulum stress and autophagy
Xiaoping Ma, Yan Li & Bing Zhao
Pages: 8076-8086
Published online: 16 Mar 2022
AbstractforRibosomal protein L5 (RPL5)/ E2F transcription factor 1 (E2F1) signaling suppresses breast cancer progression via regulating endoplasmic reticulum stress and autophagy | Full Text | References | PDF (2.1 MB) | EPUB
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Article
LEM domain containing 1 (LEMD1) transcriptionally activated by SRY-related high-mobility-group box 4 (SOX4) accelerates the progression of colon cancer by upregulating phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway
Ding Li, Ding Wang, Haofeng Liu & Xiaohui Jiang
Pages: 8087-8100
Published online: 16 Mar 2022
AbstractforLEM domain containing 1 (LEMD1) transcriptionally activated by SRY-related high-mobility-group box 4 (SOX4) accelerates the progression of colon cancer by upregulating phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway | Full Text | References | PDF (3.9 MB) | EPUB
  • 1264 Views
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Article
Neuropeptide Y in the amygdala contributes to neuropathic pain-like behaviors in rats via the neuropeptide Y receptor type 2/mitogen-activated protein kinase axis
Wenhui Yan, Wuchao Liu, Junlu Wu, Lipei Wu, Shihai Xuan, Weiwei Wang & Anquan Shang
Pages: 8101-8114
Published online: 21 Mar 2022
AbstractforNeuropeptide Y in the amygdala contributes to neuropathic pain-like behaviors in rats via the neuropeptide Y receptor type 2/mitogen-activated protein kinase axis | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Review

Review Article
Microbial electrolysis: a promising approach for treatment and resource recovery from industrial wastewater
Yamini Koul, Viralkunvar Devda, Sunita Varjani, Wenshan Guo, Huu Hao Ngo, Mohammad J. Taherzadeh, Jo-Shu Chang, Jonathan W. C. Wong, Muhammad Bilal, Sang-Hyoun Kim, Xuan-Thanh Bui & Roberto Parra-Saldívar
Pages: 8115-8134
Published online: 17 Mar 2022
AbstractforMicrobial electrolysis: a promising approach for treatment and resource recovery from industrial wastewater | Full Text | References | PDF (1.2 MB) | EPUB
  • 4458 Views
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Review Article
Recent advances in metabolic engineering of microorganisms for advancing lignocellulose-derived biofuels
Abhishek Joshi, Krishan K. Verma, Vishnu D Rajput, Tatiana Minkina & Jaya Arora
Pages: 8135-8163
Published online: 17 Mar 2022
AbstractforRecent advances in metabolic engineering of microorganisms for advancing lignocellulose-derived biofuels | Full Text | References | PDF (1.6 MB) | EPUB
  • 5354 Views
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Research Paper

Article
The double homeobox a pseudogene 8 accelerates cell proliferation, migration, and invasion in colon cancer
Shengxun Mao, Zhaohong Mo, Runxin Wu, Bin Lai, Zhiyong Zhou, Yi Song, Xi Ouyang & Xingen Zhu
Pages: 8164-8173
Published online: 24 Mar 2022
AbstractforThe double homeobox a pseudogene 8 accelerates cell proliferation, migration, and invasion in colon cancer | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 1061 Views
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Open Access
Article
miR-877-3p inhibits tumor growth and angiogenesis of osteosarcoma through fibroblast growth factor 2 signaling
Mingji Chen, Zhi Li, Lei cao, Chi Fang, Rufeng Gao & Chao Liu
Pages: 8174-8186
Published online: 21 Mar 2022
AbstractformiR-877-3p inhibits tumor growth and angiogenesis of osteosarcoma through fibroblast growth factor 2 signaling | Full Text | References | PDF (2.8 MB) | EPUB
  • 1538 Views
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Open Access
Article
Danhong injection represses diabetic retinopathy and nephropathy advancement in diabetic mice by upregulating microRNA-30d-5p and targeting JAK1
Wei Deng, Dan Huang, HongWu Xie, LiMin Wang, Qun Shen, RongRong Zeng, YuanLian Huang, JianHua Li & Bo Yang
Pages: 8187-8200
Published online: 31 Mar 2022
AbstractforDanhong injection represses diabetic retinopathy and nephropathy advancement in diabetic mice by upregulating microRNA-30d-5p and targeting JAK1 | Full Text | References | PDF (5 MB) | EPUB
  • 1948 Views
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Open Access
Article
Long non-coding RNA metastasis-related lung adenocarcinoma transcript 1 (MALAT1) forms a negative feedback loop with long non-coding RNA colorectal neoplasia differentially expressed (CRNDE) in sepsis to regulate lung cell apoptosis
Caifang Yue, Muhan He, Yanping Teng & Xiaoli Bian
Pages: 8201-8207
Published online: 18 Mar 2022
AbstractforLong non-coding RNA metastasis-related lung adenocarcinoma transcript 1 (MALAT1) forms a negative feedback loop with long non-coding RNA colorectal neoplasia differentially expressed (CRNDE) in sepsis to regulate lung cell apoptosis | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Long non-coding RNA PTPRG-AS1/microRNA-124-3p regulates radiosensitivity of nasopharyngeal carcinoma via the LIM Homeobox 2-dependent Notch pathway through competitive endogenous RNA mechanism
Zhangquan Shen, Yang Wu & Guijun He
Pages: 8208-8225
Published online: 17 Mar 2022
AbstractforLong non-coding RNA PTPRG-AS1/microRNA-124-3p regulates radiosensitivity of nasopharyngeal carcinoma via the LIM Homeobox 2-dependent Notch pathway through competitive endogenous RNA mechanism | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
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Article
Long non-coding RNA ADAMTS9-AS1 attenuates ferroptosis by Targeting microRNA-587/solute carrier family 7 member 11 axis in epithelial ovarian cancer
Li Cai, Xiaoqing Hu, Lu Ye, Pingjuan Bai, Youkun Jie & Kuanyong Shu
Pages: 8226-8239
Published online: 21 Mar 2022
AbstractforLong non-coding RNA ADAMTS9-AS1 attenuates ferroptosis by Targeting microRNA-587/solute carrier family 7 member 11 axis in epithelial ovarian cancer | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Astragaloside-IV alleviates high glucose-induced ferroptosis in retinal pigment epithelial cells by disrupting the expression of miR-138-5p/Sirt1/Nrf2
Xuyuan Tang, Xiuyi Li, Dongyan Zhang & Wei Han
Pages: 8238-8253
Published online: 18 Mar 2022
AbstractforAstragaloside-IV alleviates high glucose-induced ferroptosis in retinal pigment epithelial cells by disrupting the expression of miR-138-5p/Sirt1/Nrf2 | Full Text | References | PDF (9.4 MB) | EPUB
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Article
MicroRNA miR-124-3p suppresses proliferation and epithelial–mesenchymal transition of hepatocellular carcinoma via ARRDC1 (arrestin domain containing 1)
Qiannan Zhao, Fen Jiang, Hui Zhuang, Yanfeng Chu, Fang Zhang & Chenghong Wang
Pages: 8255-8265
Published online: 18 Mar 2022
AbstractforMicroRNA miR-124-3p suppresses proliferation and epithelial–mesenchymal transition of hepatocellular carcinoma via ARRDC1 (arrestin domain containing 1) | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 1298 Views
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Open Access
Article
Serum miR-497-5p serves as a diagnostic biomarker for acute coronary syndrome and predicts the occurrence of major adverse cardiovascular events after percutaneous coronary intervention
Tao Chen, Xueshan Zhang, Wei Qian, Ran Zhou, Mingyu Su & Yanfeng Ma
Pages: 8266-8276
Published online: 18 Mar 2022
AbstractforSerum miR-497-5p serves as a diagnostic biomarker for acute coronary syndrome and predicts the occurrence of major adverse cardiovascular events after percutaneous coronary intervention | Full Text | References | PDF (832.8 KB) | EPUB
  • 950 Views
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Article
Hsa_circ_0000081 promotes the function of gastric cancer through sponging hsa-miR-423-5p to influence 3-phosphoinositide-dependent kinase 1 expression
Fei Jiang, Xueju Hu, Hongyong Cao & Xiaobing Shen
Pages: 8277-8290
Published online: 18 Mar 2022
AbstractforHsa_circ_0000081 promotes the function of gastric cancer through sponging hsa-miR-423-5p to influence 3-phosphoinositide-dependent kinase 1 expression | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 1264 Views
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Open Access
Article
Chrysin reduces inflammation and oxidative stress and improves ovarian function in D-gal-induced premature ovarian failure
Xinning Li, Xuelan Li & Ling Deng
Pages: 8291-8301
Published online: 24 Mar 2022
AbstractforChrysin reduces inflammation and oxidative stress and improves ovarian function in D-gal-induced premature ovarian failure | Full Text | References | PDF (2.2 MB) | EPUB
  • 2313 Views
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Article
Long non-coding RNA NCK1-AS1 is overexpressed in esophageal squamous cell carcinoma and predicts survival
Xin Fu, Xi Chen, Yuanyuan Si, Youjie Yao, Zhengming Jiang & Kui Chen
Pages: 8302-8310
Published online: 21 Mar 2022
AbstractforLong non-coding RNA NCK1-AS1 is overexpressed in esophageal squamous cell carcinoma and predicts survival | Full Text | References | PDF (2.1 MB) | EPUB
  • 743 Views
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Article
Hsa_circ_0072008 regulates cell proliferation, migration, and invasion in cervical squamous cell carcinoma via miR-1305/helicase, lymphoid specific (HELLS) axis
Chunhua He & Leng Liu
Pages: 8311-8322
Published online: 21 Mar 2022
AbstractforHsa_circ_0072008 regulates cell proliferation, migration, and invasion in cervical squamous cell carcinoma via miR-1305/helicase, lymphoid specific (HELLS) axis | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 884 Views
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Article
Tripartite motif 27 promotes cardiac hypertrophy via PTEN/Akt/mTOR signal pathways
Yan Chen, Zewen Liu, Zhengqing Hu, Xiuyuan Feng & Li Zuo
Pages: 8321-8331
Published online: 21 Mar 2022
AbstractforTripartite motif 27 promotes cardiac hypertrophy via PTEN/Akt/mTOR signal pathways | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 1659 Views
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Article
Liraglutide attenuates hepatic iron levels and ferroptosis in db/db mice
Ji-Xian Song, Ji-Ren An, Qi Chen, Xin-Yue Yang, Cui-Ling Jia, Shan Xu, Ya-shuo Zhao & En-Sheng Ji
Pages: 8334-8348
Published online: 21 Mar 2022
AbstractforLiraglutide attenuates hepatic iron levels and ferroptosis in db/db mice | Full Text | References | PDF (4.6 MB) | EPUB
  • 6471 Views
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Article
Nuclear receptor 4A1 (NR4A1) silencing protects hepatocyte against hypoxia-reperfusion injury in vitro by activating liver kinase B1 (LKB1)/AMP-activated protein kinase (AMPK) signaling
Yu Zheng, Yingying Tao, Xiaobo Zhan & Qi Wu
Pages: 8349-8359
Published online: 21 Mar 2022
AbstractforNuclear receptor 4A1 (NR4A1) silencing protects hepatocyte against hypoxia-reperfusion injury in vitro by activating liver kinase B1 (LKB1)/AMP-activated protein kinase (AMPK) signaling | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 1713 Views
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Article
Fibroblast growth factor receptor 2 promotes the proliferation, migration, and invasion of ectopic stromal cells via activation of extracellular-signal-regulated kinase signaling pathway in endometriosis
Yuan Xu, Feng Gao, Jingyong Zhang, Pingping Cai & Dongsheng Xu
Pages: 8360-8371
Published online: 21 Mar 2022
AbstractforFibroblast growth factor receptor 2 promotes the proliferation, migration, and invasion of ectopic stromal cells via activation of extracellular-signal-regulated kinase signaling pathway in endometriosis | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 1638 Views
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Article
Long non-coding RNA GAS5 contributes to the progression of nonalcoholic fatty liver disease by targeting the microRNA-29a-3p/NOTCH2 axis
Juanjuan Cui, Yang Wang & Haowei Xue
Pages: 8370-8381
Published online: 24 Mar 2022
AbstractforLong non-coding RNA GAS5 contributes to the progression of nonalcoholic fatty liver disease by targeting the microRNA-29a-3p/NOTCH2 axis | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 1818 Views
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Article
MicroRNA-631 deriving from bone marrow mesenchymal stem cell exosomes facilitates the malignant behavior of non-small cell lung cancer via modulating the E2F family of transcription factor 2/phosphatidylinositol 3‐kinase/Akt signaling pathway
Hong Lv, Jing Yu, Hao Zhang, Xingjia Qian, Qian Wang, Bing Lu & Yifeng Sun
Pages: 8382-8395
Published online: 30 Mar 2022
AbstractforMicroRNA-631 deriving from bone marrow mesenchymal stem cell exosomes facilitates the malignant behavior of non-small cell lung cancer via modulating the E2F family of transcription factor 2/phosphatidylinositol 3‐kinase/Akt signaling pathway | Full Text | References | PDF (3.9 MB) | EPUB
  • 1150 Views
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Article
Fluoxetine attenuates apoptosis in early brain injury after subarachnoid hemorrhage through Notch1/ASK1/p38 MAPK signaling pathway
Ming Liu, Weiying Zhong, Chao Li & Wandong Su
Pages: 8396-8411
Published online: 06 Apr 2022
AbstractforFluoxetine attenuates apoptosis in early brain injury after subarachnoid hemorrhage through Notch1/ASK1/p38 MAPK signaling pathway | Full Text | References | PDF (4.1 MB) | EPUB
  • 1188 Views
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Article
LINC01315 accelerates the growth and epithelial-mesenchymal transition of colorectal cancer cells via activating the Wnt/β-catenin signal
Yang Liu & Wen Li Zhou
Pages: 8396-8406
Published online: 24 Mar 2022
AbstractforLINC01315 accelerates the growth and epithelial-mesenchymal transition of colorectal cancer cells via activating the Wnt/β-catenin signal | Full Text | References | PDF (3.4 MB) | EPUB
  • 885 Views
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Article
Circ_0005526 contributes to interleukin-1β-induced chondrocyte injury in osteoarthritis via upregulating transcription factor 4 by interacting with miR-142-5p
Paerhati Wahafu, Aixian Xu, Bo Zhao, Yanan Tuo & Junkui Yang
Pages: 8407-8418
Published online: 24 Mar 2022
AbstractforCirc_0005526 contributes to interleukin-1β-induced chondrocyte injury in osteoarthritis via upregulating transcription factor 4 by interacting with miR-142-5p | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 1071 Views
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Article
Delivery of astragalus polysaccharide by ultrasound microbubbles attenuate doxorubicin-induced cardiomyopathy in rodent animals
Yanjie Liu, Li Chen, Hao Wu & Hebin Zhang
Pages: 8419-8431
Published online: 24 Mar 2022
AbstractforDelivery of astragalus polysaccharide by ultrasound microbubbles attenuate doxorubicin-induced cardiomyopathy in rodent animals | Full Text | References | PDF (1.6 MB) | EPUB
  • 1597 Views
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Review

Review Article
A review on biofiltration techniques: recent advancements in the removal of volatile organic compounds and heavy metals in the treatment of polluted water
Rekha Pachaiappan, Lorena Cornejo-Ponce, Rathika Rajendran, Kovendhan Manavalan, Vincent Femilaa Rajan & Fathi Awad
Pages: 8432-8477
Published online: 28 Mar 2022
AbstractforA review on biofiltration techniques: recent advancements in the removal of volatile organic compounds and heavy metals in the treatment of polluted water | Full Text | References | PDF (3.9 MB) | EPUB
  • 10917 Views
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Research Paper

Article
The cancer-testis antigen a-kinase anchor protein 3 facilitates breast cancer progression via activation of the PTEN/PI3K/AKT/mTOR signaling
Chuan-Hua Zhan, Dong-Shen Ding, Wei Zhang, Hong-Liang Wang, Zhe-Yu Mao & Guo-Jun Liu
Pages: 8478-8489
Published online: 24 Mar 2022
AbstractforThe cancer-testis antigen a-kinase anchor protein 3 facilitates breast cancer progression via activation of the PTEN/PI3K/AKT/mTOR signaling | Full Text | References | PDF (2.7 MB) | EPUB
  • 1106 Views
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Article
Epigallocatechin-3-gallate suppresses the growth of human osteosarcoma by inhibiting the Wnt/β-catenin signalling pathway
Chaoqun Dong, Zhigang Wang, Peng Shen, Yingguo Chen, Jinshu Wang & Hongbo Wang
Pages: 8490-8502
Published online: 29 Mar 2022
AbstractforEpigallocatechin-3-gallate suppresses the growth of human osteosarcoma by inhibiting the Wnt/β-catenin signalling pathway | Full Text | References | PDF (19.1 MB) | EPUB
  • 1124 Views
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Article
miR-125a attenuates the malignant biological behaviors of cervical squamous cell carcinoma cells through Rad51
Zeping Liu, Jinchang Huang, Qiuju Jiang, Xiaoling Li, Xiaohui Tang, Shasha Chen, Liling Jiang, Genghua Fu & Sijun Liu
Pages: 8503-8514
Published online: 25 Mar 2022
AbstractformiR-125a attenuates the malignant biological behaviors of cervical squamous cell carcinoma cells through Rad51 | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 918 Views
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Article
Exosomes from human adipose-derived mesenchymal stem cells inhibit production of extracellular matrix in keloid fibroblasts via downregulating transforming growth factor-β2 and Notch-1 expression
Jing Li, Zhiyu Li, Song Wang, Jianhai Bi & Ran Huo
Pages: 8515-8525
Published online: 25 Mar 2022
AbstractforExosomes from human adipose-derived mesenchymal stem cells inhibit production of extracellular matrix in keloid fibroblasts via downregulating transforming growth factor-β2 and Notch-1 expression | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 3011 Views
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Article
Upregulated long intergenic non-protein coding RNA 1094 (LINC01094) is linked to poor prognosis and alteration of cell function in colorectal cancer
Guangliang Zhang, Yingjie Gao, Zhen Yu & Hui Su
Pages: 8526-8537
Published online: 24 Mar 2022
AbstractforUpregulated long intergenic non-protein coding RNA 1094 (LINC01094) is linked to poor prognosis and alteration of cell function in colorectal cancer | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 716 Views
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Article
Lysine (K)-specific demethylase 5C regulates the incidence of severe preeclampsia by adjusting the expression of bone morphogenetic protein-7
Xu-Feng Shi, Zhan Zhang, Hai-Ying Wu, Yu Wang, Ai-Min Chang, Jun-Jun Gao, Kan Liu, Wan-Yu Song, Li Wang & Huan-Ping Wang
Pages: 8538-8547
Published online: 24 Mar 2022
AbstractforLysine (K)-specific demethylase 5C regulates the incidence of severe preeclampsia by adjusting the expression of bone morphogenetic protein-7 | Full Text | References | PDF (1.2 MB) | EPUB
  • 867 Views
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Article
The abnormal phosphorylation of the Rac1, Lim-kinase 1, and Cofilin proteins in the pathogenesis of Hirschsprung’s disease
Wan-Kang Zhou, Yan Qu, Yuan-Mei Liu, Ming-Juan Gao, Cheng-Yan Tang, Lu Huang, Qing Du & Jia Yin
Pages: 8548-8557
Published online: 24 Mar 2022
AbstractforThe abnormal phosphorylation of the Rac1, Lim-kinase 1, and Cofilin proteins in the pathogenesis of Hirschsprung’s disease | Full Text | References | PDF (1.5 MB) | EPUB
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Article
Application of two on-site quantitative methods for the detection of total chlorine in the water in the hemodialysis industry
Wen Zhang & Wen Huang
Pages: 8558-8566
Published online: 24 Mar 2022
AbstractforApplication of two on-site quantitative methods for the detection of total chlorine in the water in the hemodialysis industry | Full Text | References | PDF (1.2 MB) | EPUB
  • 585 Views
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Article
Targeting Forkhead box O1-aquaporin 5 axis mitigates neuropathic pain in a CCI rat model through inhibiting astrocytic and microglial activation
Yaoping Yu, Meng Wang, Xiao Yu, Yi Yan, Bo Yu & Dayin Zhang
Pages: 8567-8580
Published online: 24 Mar 2022
AbstractforTargeting Forkhead box O1-aquaporin 5 axis mitigates neuropathic pain in a CCI rat model through inhibiting astrocytic and microglial activation | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 1764 Views
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Article
PolyC-RNA-binding protein 1 (PCBP1) enhances tropomyosin 3 (TPM3) mRNA stability to promote the progression of esophageal squamous cell carcinoma
Kaiming Peng, Xiaoqiang Chen, Anqin Lin, Zhangwei Tong & Wenwei Lin
Pages: 8581-8592
Published online: 24 Mar 2022
AbstractforPolyC-RNA-binding protein 1 (PCBP1) enhances tropomyosin 3 (TPM3) mRNA stability to promote the progression of esophageal squamous cell carcinoma | Full Text | References | PDF (3.2 MB) | EPUB
  • 1255 Views
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Article
MCC950 ameliorates ventricular arrhythmia vulnerability induced by heart failure
Xiaobo Jiang, Fan Yang, Dengke Ou, Luyong Huang, Hongfei Li & Mingjian Lang
Pages: 8593-8604
Published online: 24 Mar 2022
AbstractforMCC950 ameliorates ventricular arrhythmia vulnerability induced by heart failure | Full Text | References | PDF (3.3 MB) | EPUB
  • 1531 Views
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Article
Male-specific long non-coding RNA testis-specific transcript, Y-linked 15 promotes gastric cancer cell growth by regulating Wnt family member 1/β-catenin signaling by sponging microRNA let-7a-5p
XiaoYing Zheng, BingJun Peng, XinChun Wu, JunLing Ye, HaiYun Zhao, YanJun Li, RuiHui Chen, Xue Gong, HaiYan Zhang & XinJian Guo
Pages: 8605-8616
Published online: 25 Mar 2022
AbstractforMale-specific long non-coding RNA testis-specific transcript, Y-linked 15 promotes gastric cancer cell growth by regulating Wnt family member 1/β-catenin signaling by sponging microRNA let-7a-5p | Full Text | References | PDF (2 MB) | EPUB
  • 1226 Views
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Article
Hyaluronan-mediated motility receptor antisense RNA 1 promotes hepatitis B virus-related hepatocellular carcinoma progression by regulating miR-627-3p/High Mobility Group AT-hook 2 axis
Hai Zhuang, Xiaoxia Ma, Xiaoyan Liu, Chao Li, Xinying Li, Ling Wu, Maofei Wen, Wenli Shi & Xiaozhou Yang
Pages: 8617-8630
Published online: 24 Mar 2022
AbstractforHyaluronan-mediated motility receptor antisense RNA 1 promotes hepatitis B virus-related hepatocellular carcinoma progression by regulating miR-627-3p/High Mobility Group AT-hook 2 axis | Full Text | References | PDF (2.9 MB) | EPUB
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Article
Potent anti-tumor activity of CD45RA-targeting Hm3A4-Ranpirnase against myeloid lineage leukemias
Sisi Li, Zhujun Wang, Xiaoping Guo, Ping Chen & Yongmin Tang
Pages: 8631-8642
Published online: 24 Mar 2022
AbstractforPotent anti-tumor activity of CD45RA-targeting Hm3A4-Ranpirnase against myeloid lineage leukemias | Full Text | References | PDF (1.4 MB) | EPUB
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Article
Terpinen-4-ol inhibits the proliferation and mobility of pancreatic cancer cells by downregulating Rho-associated coiled-coil containing protein kinase 2
Wenpeng Cao, Ruhua Tian, Runsang Pan, Baofei Sun, Chaolun Xiao, Yunhua Chen, Zhirui Zeng & Shan Lei
Pages: 8643-8656
Published online: 24 Mar 2022
AbstractforTerpinen-4-ol inhibits the proliferation and mobility of pancreatic cancer cells by downregulating Rho-associated coiled-coil containing protein kinase 2 | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
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Article
Hyperoside exerts osteoprotective effect on dexamethasone-induced osteoblasts by targeting NADPH Oxidase 4 (NOX4) to inhibit the reactive oxygen species (ROS) accumulation and activate c-Jun N-terminal kinase (JNK) pathway
Siqi Fan, Haida Pan, Jiaxing Huang, Zhiqiang Lei & Jinfu Liu
Pages: 8657-8666
Published online: 24 Mar 2022
AbstractforHyperoside exerts osteoprotective effect on dexamethasone-induced osteoblasts by targeting NADPH Oxidase 4 (NOX4) to inhibit the reactive oxygen species (ROS) accumulation and activate c-Jun N-terminal kinase (JNK) pathway | Full Text | References | PDF (3 MB) | EPUB
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Article
MicroRNA-486-5p functions as a diagnostic marker for carotid artery stenosis and prevents endothelial dysfunction through inhibiting inflammation and oxidative stress
Bin Zhu, Wei Liu, Qiang Xu & Hong-Liang Liu
Pages: 8667-8675
Published online: 24 Mar 2022
AbstractforMicroRNA-486-5p functions as a diagnostic marker for carotid artery stenosis and prevents endothelial dysfunction through inhibiting inflammation and oxidative stress | Full Text | References | PDF (996.1 KB) | EPUB | Supplemental
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Article
Long non-coding RNA MEG3 promotes tumor necrosis factor-alpha induced oxidative stress and apoptosis in interstitial cells of cajal via targeting the microRNA-21 /I-kappa-B-kinase beta axis
Jia Li, Junbo Bai, Nafeisha Tuerdi & Kaifang Liu
Pages: 8676-8688
Published online: 24 Mar 2022
AbstractforLong non-coding RNA MEG3 promotes tumor necrosis factor-alpha induced oxidative stress and apoptosis in interstitial cells of cajal via targeting the microRNA-21 /I-kappa-B-kinase beta axis | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
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Research article

Article
The protective effect of hederagenin on renal fibrosis by targeting muscarinic acetylcholine receptor
Wei Yang & Lijuan He
Pages: 8689-8698
Published online: 24 Mar 2022
AbstractforThe protective effect of hederagenin on renal fibrosis by targeting muscarinic acetylcholine receptor | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
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Research Paper

Article
LncRNA RPSAP52 promotes cell proliferation and inhibits cell apoptosis via modulating miR-665/STAT3 in gastric cancer
Chao He, Yuanyuan Liu, Jinhou Li, Xiao Zheng, Jianwei Liang, Gang Cui & Hong Chang
Pages: 8699-8711
Published online: 24 Mar 2022
AbstractforLncRNA RPSAP52 promotes cell proliferation and inhibits cell apoptosis via modulating miR-665/STAT3 in gastric cancer | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Cullin 4A/protein arginine methyltransferase 5 (CUL4A/PRMT5) promotes cell malignant phenotypes and tumor growth in nasopharyngeal carcinoma
Xiuying Sun, Jinhui Zhou & Zhicun Zhang
Pages: 8712-8723
Published online: 25 Mar 2022
AbstractforCullin 4A/protein arginine methyltransferase 5 (CUL4A/PRMT5) promotes cell malignant phenotypes and tumor growth in nasopharyngeal carcinoma | Full Text | References | PDF (6.6 MB) | EPUB
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Article
MicroRNA-30a contributes to pre-eclampsia through regulating the proliferation, apoptosis, and angiogenesis modulation potential of mesenchymal stem cells by targeting AVEN
Fangle Gu, Dan Lu & Liying Zhang
Pages: 8724-8734
Published online: 24 Mar 2022
AbstractforMicroRNA-30a contributes to pre-eclampsia through regulating the proliferation, apoptosis, and angiogenesis modulation potential of mesenchymal stem cells by targeting AVEN | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Carboxymethyl chitosan-grafted polyvinylpyrrolidone-iodine microspheres for promoting the healing of chronic wounds
Jie Yu, Pei Wang, Mengting Yin, Kaiwen Zhang, Xiansong Wang & Bing Han
Pages: 8735-8746
Published online: 24 Mar 2022
AbstractforCarboxymethyl chitosan-grafted polyvinylpyrrolidone-iodine microspheres for promoting the healing of chronic wounds | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
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Article
Echinococcus multilocularis drives the polarization of macrophages by regulating the RhoA-MAPK signaling pathway and thus affects liver fibrosis
Shigui Chong, Gen Chen, Zhisheng Dang, Fuqiu Niu, Linghui Zhang, Hui Ma & Yumin Zhao
Pages: 8747-8758
Published online: 24 Mar 2022
AbstractforEchinococcus multilocularis drives the polarization of macrophages by regulating the RhoA-MAPK signaling pathway and thus affects liver fibrosis | Full Text | References | PDF (2.1 MB) | EPUB
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Article
Circular RNA Sirtuin1 represses pulmonary artery smooth muscle cell proliferation, migration and autophagy to ameliorate pulmonary hypertension via targeting microRNA-145-5p/protein kinase-B3 axis
Xiaogang Jing, Shujun Wu, Ying Liu, Huan Wang & QingFeng Huang
Pages: 8759-8771
Published online: 03 Apr 2022
AbstractforCircular RNA Sirtuin1 represses pulmonary artery smooth muscle cell proliferation, migration and autophagy to ameliorate pulmonary hypertension via targeting microRNA-145-5p/protein kinase-B3 axis | Full Text | References | PDF (7.8 MB) | EPUB
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Article
Kukoamine A attenuates lipopolysaccharide-induced apoptosis, extracellular matrix degradation, and inflammation in nucleus pulposus cells by activating the P13K/Akt pathway
Dan Wang, Hao Qu, Hui Kang, Feng Xu, Wei Huang & Xianhua Cai
Pages: 8772-8784
Published online: 25 Mar 2022
AbstractforKukoamine A attenuates lipopolysaccharide-induced apoptosis, extracellular matrix degradation, and inflammation in nucleus pulposus cells by activating the P13K/Akt pathway | Full Text | References | PDF (3.2 MB) | EPUB
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Article
Serine hydroxymethyltransferase 2 (SHMT2) potentiates the aggressive process of oral squamous cell carcinoma by binding to interleukin enhancer-binding factor 2 (ILF2)
Hui Zhang, Yilei Che, Bin Xuan, Xiaozhen Wu & Hui Li
Pages: 8785-8797
Published online: 25 Mar 2022
AbstractforSerine hydroxymethyltransferase 2 (SHMT2) potentiates the aggressive process of oral squamous cell carcinoma by binding to interleukin enhancer-binding factor 2 (ILF2) | Full Text | References | PDF (5.5 MB) | EPUB
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Article
MicorRNA-195 links long non-coding RNA SEMA3B antisense RNA 1 (head to head) and cyclin D1 to regulate the proliferation of glioblastoma cells
Kaijun Liu, Yan Deng, Yongxia Yang, Hui Wang & Ping Zhou
Pages: 8798-8805
Published online: 31 Mar 2022
AbstractforMicorRNA-195 links long non-coding RNA SEMA3B antisense RNA 1 (head to head) and cyclin D1 to regulate the proliferation of glioblastoma cells | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Article
Hsa_circ_0017639 regulates cisplatin resistance and tumor growth via acting as a miR-1296-5p molecular sponge and modulating sine oculis homeobox 1 expression in non-small cell lung cancer
Feiyun Chang, Jiali Li, Quan Sun, Shuqing Wei & Yongming Song
Pages: 8806-8822
Published online: 28 Mar 2022
AbstractforHsa_circ_0017639 regulates cisplatin resistance and tumor growth via acting as a miR-1296-5p molecular sponge and modulating sine oculis homeobox 1 expression in non-small cell lung cancer | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
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Article
Circular RNA LONP2 regulates proliferation, invasion, and apoptosis of bladder cancer cells by sponging microRNA-584-5p
Xu Zhang, Hao Xiong, Yong Zhao, Shengqiang Lin, Xiang Huang, Cheng Lin, Shihui Mao & Demin Chen
Pages: 8823-8835
Published online: 31 Mar 2022
AbstractforCircular RNA LONP2 regulates proliferation, invasion, and apoptosis of bladder cancer cells by sponging microRNA-584-5p | Full Text | References | PDF (2.9 MB) | EPUB
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Article
The crystallin alpha B (HSPB5)-tripartite motif containing 33 (TRIM33) axis mediates myocardial fibrosis induced by angiotensinogen II through transforming growth factor-β (TGF-β1)-Smad3/4 signaling
Tianwen Wei, Yingqiang Du, Tiankai Shan, Jiawen Chen, Dongwei Shi, Tongtong Yang, Jiankang Wang, Jun Zhang & Yafei Li
Pages: 8836-8849
Published online: 25 Mar 2022
AbstractforThe crystallin alpha B (HSPB5)-tripartite motif containing 33 (TRIM33) axis mediates myocardial fibrosis induced by angiotensinogen II through transforming growth factor-β (TGF-β1)-Smad3/4 signaling | Full Text | References | PDF (4.1 MB) | EPUB
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Research Article

Article
Human umbilical vein endothelial cells-derived exosomes enhance cardiac function after acute myocardial infarction by activating the PI3K/AKT signaling pathway
Wei Liu, Yu Feng, Xuehua Wang, Jiaxing Ding, Huili Li, Hongquan Guan & Zhijian Chen
Pages: 8850-8865
Published online: 31 Mar 2022
AbstractforHuman umbilical vein endothelial cells-derived exosomes enhance cardiac function after acute myocardial infarction by activating the PI3K/AKT signaling pathway | Full Text | References | PDF (7 MB) | EPUB | Supplemental
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Research Paper

Article
Analysis of volatile organic compounds and metabolites of three cultivars of asparagus (Asparagus officinalis L.) using E-nose, GC-IMS, and LC-MS/MS
Chun Yang, Zheng Ye, Liping Mao, Ling Zhang, Jiangning Zhang, Weiying Ding, Jiming Han & Kai Mao
Pages: 8866-8880
Published online: 28 Mar 2022
AbstractforAnalysis of volatile organic compounds and metabolites of three cultivars of asparagus (Asparagus officinalis L.) using E-nose, GC-IMS, and LC-MS/MS | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Article
Restoration of miR-23a expression by chidamide sensitizes CML cells to imatinib treatment with concomitant downregulation of CRYAB
Xunxun Zhu, Jingru Zhang, Yanping Sun, Yan Wang, Qian Liu, Peng Li, Shuang Yu, Na Liu, Jingjing Ye, Daoxin Ma & Chunyan Ji
Pages: 8881-8892
Published online: 25 Mar 2022
AbstractforRestoration of miR-23a expression by chidamide sensitizes CML cells to imatinib treatment with concomitant downregulation of CRYAB | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
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Review

Review Article
Multifunctional applications of bamboo crop beyond environmental management: an Indian prospective
Rashmi Rathour, Hemant Kumar, Komal Prasad, Prathmesh Anerao, Manish Kumar, Atya Kapley, Ashok Pandey, Mukesh Kumar Awasthi & Lal Singh
Pages: 8893-8914
Published online: 25 Mar 2022
AbstractforMultifunctional applications of bamboo crop beyond environmental management: an Indian prospective | Full Text | References | PDF (549.7 KB) | EPUB
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Research Paper

Article
Necdin, one of the important pathway proteins in the regulation of osteosarcoma progression by microRNA-200c
Jian Li, Zhuangzhuang Wu, Jiani Wang, Taiyong Wu, Zhen Shen, Long Zhang, Jia Lv, Junjun Bai & Yi Feng
Pages: 8915-8925
Published online: 25 Mar 2022
AbstractforNecdin, one of the important pathway proteins in the regulation of osteosarcoma progression by microRNA-200c | Full Text | References | PDF (5 MB) | EPUB
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Article
Knockdown of lectin-like oxidized low-density lipoprotein-1 ameliorates alcoholic cardiomyopathy via inactivating the p38 mitogen-activated protein kinase pathway
Yifan Zhang, Ruiqi Zhang, Lan Lu, Na Zhou, Xiaoyan Lv, Xin Wang & Zhanbin Feng
Pages: 8926-8936
Published online: 25 Mar 2022
AbstractforKnockdown of lectin-like oxidized low-density lipoprotein-1 ameliorates alcoholic cardiomyopathy via inactivating the p38 mitogen-activated protein kinase pathway | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
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Article
Cancer-released exosomal circular RNA circ_0008717 promotes cell tumorigenicity through microRNA-1287-5p/P21-activated kinase 2 (PAK2) axis in non-small cell lung cancer
Huimin Wang, Zhiqin Tang, Jihui Duan, Chunlei Zhou, Ke Xu & Hong Mu
Pages: 8937-8949
Published online: 25 Mar 2022
AbstractforCancer-released exosomal circular RNA circ_0008717 promotes cell tumorigenicity through microRNA-1287-5p/P21-activated kinase 2 (PAK2) axis in non-small cell lung cancer | Full Text | References | PDF (3.5 MB) | EPUB
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Article
Epigallocatechin gallate attenuates tumor necrosis factor (TNF)-α-induced inhibition of osteoblastic differentiation by up-regulating lncRNA TUG1 in osteoporosis
Yanfeng Han, Dening Pei, Wenjing Li, Bin Luo & Qingsong Jiang
Pages: 8950-8961
Published online: 31 Mar 2022
AbstractforEpigallocatechin gallate attenuates tumor necrosis factor (TNF)-α-induced inhibition of osteoblastic differentiation by up-regulating lncRNA TUG1 in osteoporosis | Full Text | References | PDF (3.8 MB) | EPUB
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Article
Inhibition of LncRNA-NEAT1 alleviates intestinal epithelial cells (IECs) dysfunction in ulcerative colitis by maintaining the homeostasis of the glucose metabolism through the miR-410-3p-LDHA axis
Siyi Ni, Yingchao Liu, Jihong Zhong & Yan Shen
Pages: 8961-8971
Published online: 28 Mar 2022
AbstractforInhibition of LncRNA-NEAT1 alleviates intestinal epithelial cells (IECs) dysfunction in ulcerative colitis by maintaining the homeostasis of the glucose metabolism through the miR-410-3p-LDHA axis | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Article
Collagen type IV alpha 1 (COL4A1) silence hampers the invasion, migration and epithelial–mesenchymal transition (EMT) of gastric cancer cells through blocking Hedgehog signaling pathway
Xijuan Cui, Tao Shan & Lina Qiao
Pages: 8972-8981
Published online: 29 Mar 2022
AbstractforCollagen type IV alpha 1 (COL4A1) silence hampers the invasion, migration and epithelial–mesenchymal transition (EMT) of gastric cancer cells through blocking Hedgehog signaling pathway | Full Text | References | PDF (3.3 MB) | EPUB
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Article
MicroRNA miR-27a-3p accelerates cardiac hypertrophy by targeting neuro-oncological ventral antigen 1
Dongyun Li, Mingzhi Shen, Xinxin Deng & Yongyi Bai
Pages: 8982-8993
Published online: 29 Mar 2022
AbstractforMicroRNA miR-27a-3p accelerates cardiac hypertrophy by targeting neuro-oncological ventral antigen 1 | Full Text | References | PDF (2.6 MB) | EPUB
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Article
LncRNA LINC01270 aggravates the progression of gastric cancer through modulation of miR-326/EFNA3 axis
Bing Jiang, Kankan Yang, Chao Tang, Rui Chen & Chao Wang
Pages: 8995-9006
Published online: 29 Mar 2022
AbstractforLncRNA LINC01270 aggravates the progression of gastric cancer through modulation of miR-326/EFNA3 axis | Full Text | References | PDF (6.2 MB) | EPUB | Supplemental
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Article
Targeting kinesin family member 21B by miR-132-3p represses cell proliferation, migration and invasion in gastric cancer
Bingtian Liu, Ling Qiang, Bingxin Guan & Zhipeng Ji
Pages: 9006-9018
Published online: 28 Mar 2022
AbstractforTargeting kinesin family member 21B by miR-132-3p represses cell proliferation, migration and invasion in gastric cancer | Full Text | References | PDF (3.6 MB) | EPUB
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Article
Actin-binding Rho activating C-terminal like (ABRACL) transcriptionally regulated by MYB proto-oncogene like 2 (MYBL2) promotes the proliferation, invasion, migration and epithelial-mesenchymal transition of breast cancer cells
Jie Li & Hui Chen
Pages: 9019-9031
Published online: 28 Mar 2022
AbstractforActin-binding Rho activating C-terminal like (ABRACL) transcriptionally regulated by MYB proto-oncogene like 2 (MYBL2) promotes the proliferation, invasion, migration and epithelial-mesenchymal transition of breast cancer cells | Full Text | References | PDF (4.7 MB) | EPUB
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Article
CircSEC24A (hsa_circ_0003528) interference suppresses epithelial-mesenchymal transition of hepatocellular carcinoma cells via miR-421/MMP3 axis
Bo Zhang & Jian Zhou
Pages: 9050-9063
Published online: 10 Apr 2022
AbstractforCircSEC24A (hsa_circ_0003528) interference suppresses epithelial-mesenchymal transition of hepatocellular carcinoma cells via miR-421/MMP3 axis | Full Text | References | PDF (10.4 MB) | EPUB
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Article
Suppression of the transforming growth factor-β signaling pathway produces a synergistic effect of combination therapy with programmed death receptor 1 blockade and radiofrequency ablation against hepatic carcinoma in mice
Xiaoxiang Fan, Lihu Gu, Shuyi Lv, Meiwu Zhang, Luhui Zhuang, Yan Zhang & Ping Chen
Pages: 9046-9058
Published online: 30 Mar 2022
AbstractforSuppression of the transforming growth factor-β signaling pathway produces a synergistic effect of combination therapy with programmed death receptor 1 blockade and radiofrequency ablation against hepatic carcinoma in mice | Full Text | References | PDF (3.6 MB) | EPUB
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Article
Mesenchymal stem cells inhibited the apoptosis of alveolar epithelial cells caused by ARDS through CXCL12/CXCR4 axis
Xiqiang He, Chenyan Li, Hua Yin, Xiaojun Tan, Jun Yi, Shujun Tian, Yan Wang & Jian Liu
Pages: 9060-9070
Published online: 04 Apr 2022
AbstractforMesenchymal stem cells inhibited the apoptosis of alveolar epithelial cells caused by ARDS through CXCL12/CXCR4 axis | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Article
Circular RNA circ_0002360 regulates the Taxol resistance and malignant behaviors of Taxol-resistant non-small cell lung cancer cells by microRNA-585-3p-dependent modulation of G protein regulated inducer of neurite outgrowth 1
Xiaohai Cui, Boxiang Zhang, Baocheng Li & Xinju Li
Pages: 9070-9085
Published online: 04 Apr 2022
AbstractforCircular RNA circ_0002360 regulates the Taxol resistance and malignant behaviors of Taxol-resistant non-small cell lung cancer cells by microRNA-585-3p-dependent modulation of G protein regulated inducer of neurite outgrowth 1 | Full Text | References | PDF (7.8 MB) | EPUB | Supplemental
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Article
Recombinant expression and biophysical characterization of Mrt4 protein that involved in mRNA turnover and ribosome assembly from Saccharomyces cerevisiae
Mohd Kashif, Mohd Asalam, Saad S. Al Shehri, Bhupendra Kumar, Neha Singh & Md Sohail Akhtar
Pages: 9103-9113
Published online: 07 Apr 2022
AbstractforRecombinant expression and biophysical characterization of Mrt4 protein that involved in mRNA turnover and ribosome assembly from Saccharomyces cerevisiae | Full Text | References | PDF (4.2 MB) | EPUB
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Article
The role of microRNA-4723-5p regulated by c-myc in triple-negative breast cancer
Xi-Xin Jin, Chao Gao, Wen-Xin Wei, Chong Jiao, Li Li, Bin-Lin Ma & Chao Dong
Pages: 9097-9105
Published online: 06 Apr 2022
AbstractforThe role of microRNA-4723-5p regulated by c-myc in triple-negative breast cancer | Full Text | References | PDF (1.1 MB) | EPUB
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Article
Overexpression of OTU domain-containing ubiquitin aldehyde-binding protein 1 exacerbates colorectal cancer malignancy by inhibiting protein degradation of β-Catenin via Ubiquitin-proteasome pathway
Daoxiong Ye, Sisi Wang, Xiaojie Wang, Yu Lin, Ying Huang & Pan Chi
Pages: 9106-9116
Published online: 30 Mar 2022
AbstractforOverexpression of OTU domain-containing ubiquitin aldehyde-binding protein 1 exacerbates colorectal cancer malignancy by inhibiting protein degradation of β-Catenin via Ubiquitin-proteasome pathway | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
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Article
MicroRNA-22-3p targeted regulating transcription factor 7-like 2 (TCF7L2) constrains the Wnt/β-catenin pathway and malignant behavior in osteosarcoma
YuanLiang Xue, Ya Guo, Ning Liu & XiangQi Meng
Pages: 9135-9147
Published online: 03 May 2022
AbstractforMicroRNA-22-3p targeted regulating transcription factor 7-like 2 (TCF7L2) constrains the Wnt/β-catenin pathway and malignant behavior in osteosarcoma | Full Text | References | PDF (5.3 MB) | EPUB
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Article
Transcriptome analysis of thymic tissues from Chinese Partridge Shank chickens with or without Newcastle disease virus LaSota vaccine injection via high-throughput RNA sequencing
Furong Nie, Jingfeng Zhang, Mengyun Li, Xuanniu Chang, Haitao Duan, Haoyan Li, Jia Zhou, Yudan Ji & Liangxing Guo
Pages: 9131-9144
Published online: 09 Apr 2022
AbstractforTranscriptome analysis of thymic tissues from Chinese Partridge Shank chickens with or without Newcastle disease virus LaSota vaccine injection via high-throughput RNA sequencing | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Article
Propofol protects cardiomyocytes from doxorubicin-induced toxic injury by activating the nuclear factor erythroid 2-related factor 2/glutathione peroxidase 4 signaling pathways
Ziyun Lu, Zhiyi Liu & Bei Fang
Pages: 9145-9155
Published online: 01 Apr 2022
AbstractforPropofol protects cardiomyocytes from doxorubicin-induced toxic injury by activating the nuclear factor erythroid 2-related factor 2/glutathione peroxidase 4 signaling pathways | Full Text | References | PDF (2.5 MB) | EPUB
  • 2015 Views
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Article
LINC01088 promotes the growth and invasion of glioma cells through regulating small nuclear ribonucleoprotein polypeptide A transcription
Tao Peng, Dong-Liang Chen & Shi-Lan Chen
Pages: 9172-9183
Published online: 07 Apr 2022
AbstractforLINC01088 promotes the growth and invasion of glioma cells through regulating small nuclear ribonucleoprotein polypeptide A transcription | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
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Article
Novel dual glucagon-like peptide-1/ glucose-dependent insulinotropic polypeptide receptor agonist attenuates diabetes and myocardial injury through inhibiting hyperglycemia, inflammation and oxidative stress in rodent animals
Ying Wang, Fei Cai, Gang Li & Yong Tao
Pages: 9184-9196
Published online: 06 Apr 2022
AbstractforNovel dual glucagon-like peptide-1/ glucose-dependent insulinotropic polypeptide receptor agonist attenuates diabetes and myocardial injury through inhibiting hyperglycemia, inflammation and oxidative stress in rodent animals | Full Text | References | PDF (14.8 MB) | EPUB
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Article
Vacuolar protein sorting-associated protein 72 homolog (VPS72) binding to lysine acetyltransferase 5 (KAT5) promotes the proliferation, invasion and migration of hepatocellular carcinoma through regulating phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway
Tiejun Chen, Yinuo Tu, Dongnuo Lv, Kunpeng Lin, Hui Tang & Wenjie Huang
Pages: 9197-9210
Published online: 06 Apr 2022
AbstractforVacuolar protein sorting-associated protein 72 homolog (VPS72) binding to lysine acetyltransferase 5 (KAT5) promotes the proliferation, invasion and migration of hepatocellular carcinoma through regulating phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway | Full Text | References | PDF (7.6 MB) | EPUB | Supplemental
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Article
Lamin B1 is a potential therapeutic target and prognostic biomarker for hepatocellular carcinoma
Yongyu Yang, Lei Gao, Junzhang Chen, Wang Xiao, Ruoqi Liu & Heping Kan
Pages: 9211-9231
Published online: 18 Apr 2022
AbstractforLamin B1 is a potential therapeutic target and prognostic biomarker for hepatocellular carcinoma | Full Text | References | PDF (41.5 MB) | EPUB | Supplemental
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Article
c-Met specific CAR-T cells as a targeted therapy for non-small cell lung cancer cell A549
Jingting Min, Chirong Long, Lu Zhang, Jiakang Duan, Honglian Fan, Fei Chu & Zhenghong Li
Pages: 9232-9248
Published online: 04 Apr 2022
Abstractforc-Met specific CAR-T cells as a targeted therapy for non-small cell lung cancer cell A549 | Full Text | References | PDF (7 MB) | EPUB | Supplemental
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Article
Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway
Wenrun Zhu, Han Tang, Juncheng Li, Rui Miranda Guedes, Lu Cao & Changan Guo
Pages: 9249-9263
Published online: 04 Apr 2022
AbstractforEllagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway | Full Text | References | PDF (4.2 MB) | EPUB
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Article
Long non-coding RNA Opa interacting protein 5-antisense RNA 1 binds to micorRNA-34a to upregulate oncogenic PD-L1 in non-small cell lung cancer
Xinwei Qiao & Feng Zhao
Pages: 9264-9273
Published online: 12 Apr 2022
AbstractforLong non-coding RNA Opa interacting protein 5-antisense RNA 1 binds to micorRNA-34a to upregulate oncogenic PD-L1 in non-small cell lung cancer | Full Text | References | PDF (12.8 MB) | EPUB | Supplemental
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Article
Matrine Combined with Mammalian Target of Rapamycin Inhibitor Enhances Anti-Tumor Efficacy of dendritic cell Vaccines in hepatocellular carcinoma
Ning Zhou, Sheng Li, Fan Zhang, Cong Chen & Yumin Li
Pages: 9274-9283
Published online: 10 Apr 2022
AbstractforMatrine Combined with Mammalian Target of Rapamycin Inhibitor Enhances Anti-Tumor Efficacy of dendritic cell Vaccines in hepatocellular carcinoma | Full Text | References | PDF (16 MB) | EPUB
  • 1496 Views
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Article
GMFG (glia maturation factor gamma) inhibits lung cancer growth by activating p53 signaling pathway
Hua Tang, Jie Liu & Jun Huang
Pages: 9284-9293
Published online: 06 Apr 2022
AbstractforGMFG (glia maturation factor gamma) inhibits lung cancer growth by activating p53 signaling pathway | Full Text | References | PDF (2.2 MB) | EPUB
  • 1091 Views
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Article
MM-associated circular RNA downregulates microRNA-19a through methylation to suppress proliferation of pancreatic adenocarcinoma cells
Xinye Qian, Wenru Zong, Liqing Ma, Zhoujing Yang, Wei Chen, Jun Yan & Jianghui Xu
Pages: 9294-9300
Published online: 07 Apr 2022
AbstractforMM-associated circular RNA downregulates microRNA-19a through methylation to suppress proliferation of pancreatic adenocarcinoma cells | Full Text | References | PDF (6.2 MB) | EPUB | Supplemental
  • 973 Views
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Article
HLA complex P5 upregulation is correlated with poor prognosis and tumor progression in esophageal squamous cell carcinoma
Yaqin Wang, Zhijun Yu, Weidong Shi, Jian Shen, Yun Guan & Feng Ni
Pages: 9302-9312
Published online: 07 Apr 2022
AbstractforHLA complex P5 upregulation is correlated with poor prognosis and tumor progression in esophageal squamous cell carcinoma | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 1690 Views
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Article
Circle RNA circ_0007331 promotes colorectal carcinoma by targeting miR-205-5p/high-mobility group A2 axis
Linhui Wang, Weiming Weng, Shuhui Yang, Shasha Yang & Richang Du
Pages: 9312-9321
Published online: 10 Apr 2022
AbstractforCircle RNA circ_0007331 promotes colorectal carcinoma by targeting miR-205-5p/high-mobility group A2 axis | Full Text | References | PDF (8.7 MB) | EPUB
  • 1042 Views
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Article
Protecting effect of emodin in experimental autoimmune encephalomyelitis mice by inhibiting microglia activation and inflammation via Myd88/PI3K/Akt/NF-κB signalling pathway
Kenan Zheng, Baojiang Lv, Lulu Wu, Chen Wang, Haoyou Xu, Xiaojun Li, Zhibing Wu, Yuanqi Zhao & Zequan Zheng
Pages: 9322-9344
Published online: 07 Apr 2022
AbstractforProtecting effect of emodin in experimental autoimmune encephalomyelitis mice by inhibiting microglia activation and inflammation via Myd88/PI3K/Akt/NF-κB signalling pathway | Full Text | References | PDF (9.3 MB) | EPUB
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Article
Fraxetin down-regulates polo-like kinase 4 (PLK4) to inhibit proliferation, migration and invasion of prostate cancer cells through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway
Zheng Ma, Yanfang Sun & Weixing Peng
Pages: 9345-9356
Published online: 07 Apr 2022
AbstractforFraxetin down-regulates polo-like kinase 4 (PLK4) to inhibit proliferation, migration and invasion of prostate cancer cells through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway | Full Text | References | PDF (5.7 MB) | EPUB | Supplemental
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Article
Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways
Zhongliang Liu, Baogui Xu, Yaping Ding, Xianjun Ding & Zuisu Yang
Pages: 9357-9368
Published online: 07 Apr 2022
AbstractforGuizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
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Article
Dexmedetomidine prevents cardiomyocytes from hypoxia/reoxygenation injury via modulating tetmethylcytosine dioxygenase 1-mediated DNA demethylation of Sirtuin1
Li Wang, Shaowei Wang, Tong Jia, Xiaojia Sun, Zhen Xing, Hui Liu, Jie Yao & Yanlin Chen
Pages: 9369-9386
Published online: 07 Apr 2022
AbstractforDexmedetomidine prevents cardiomyocytes from hypoxia/reoxygenation injury via modulating tetmethylcytosine dioxygenase 1-mediated DNA demethylation of Sirtuin1 | Full Text | References | PDF (5.9 MB) | EPUB
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Article
Omarigliptin alleviates cognitive dysfunction in Streptozotocin-induced diabetic mouse
Xiaoyan Li, Ying Yin, Wenfeng Li, Shanshan Li, Dandan Zhang & Zehong Liu
Pages: 9387-9396
Published online: 07 Apr 2022
AbstractforOmarigliptin alleviates cognitive dysfunction in Streptozotocin-induced diabetic mouse | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Hox transcript antisense RNA knockdown inhibits osteosarcoma progression by regulating the phosphoinositide 3-kinase/AKT pathway through the microRNA miR-6888-3p/spleen tyrosine kinase axis
Wei Wu, Linxiu Wang & Sen Li
Pages: 9397-9410
Published online: 17 Apr 2022
AbstractforHox transcript antisense RNA knockdown inhibits osteosarcoma progression by regulating the phosphoinositide 3-kinase/AKT pathway through the microRNA miR-6888-3p/spleen tyrosine kinase axis | Full Text | References | PDF (5.4 MB) | EPUB | Supplemental
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Article
Long non-coding RNA-PCGEM1 contributes to prostate cancer progression by sponging microRNA miR-129-5p to enhance chromatin licensing and DNA replication factor 1 expression
Qiao Fu, Fangfang Wang, Jun Yang, Wei Sun, Zhi Hu, Lv Xu, Hao Chu, Xiao Wang & Wei Zhang
Pages: 9411-9424
Published online: 12 Apr 2022
AbstractforLong non-coding RNA-PCGEM1 contributes to prostate cancer progression by sponging microRNA miR-129-5p to enhance chromatin licensing and DNA replication factor 1 expression | Full Text | References | PDF (4.3 MB) | EPUB | Supplemental
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Article
Long non-coding RNA human leucocyte antigen complex group-18 HCG18 (HCG18) promoted cell proliferation and migration in head and neck squamous cell carcinoma through cyclin D1-WNT pathway
Bin Mao, Fan Wang, Jingxia Zhang, Qianqian Li & Kai Ying
Pages: 9425-9434
Published online: 07 Apr 2022
AbstractforLong non-coding RNA human leucocyte antigen complex group-18 HCG18 (HCG18) promoted cell proliferation and migration in head and neck squamous cell carcinoma through cyclin D1-WNT pathway | Full Text | References | PDF (6 MB) | EPUB
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Review

Review Article
Peptide candidates for the development of therapeutics and vaccines against β-coronavirus infection
Rounak Chourasia, Srichandan Padhi, Loreni Chiring Phukon, Md Minhajul Abedin, Ranjana Sirohi, Sudhir P Singh & Amit Kumar Rai
Pages: 9435-9454
Published online: 07 Apr 2022
AbstractforPeptide candidates for the development of therapeutics and vaccines against β-coronavirus infection | Full Text | References | PDF (2 MB) | EPUB
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Research Paper

Article
Role of sirtuin 1 in the brain development in congenital hypothyroidism rats via the regulation of p53 signaling pathway
Xiaofang Wei, Juan Tan & Hui Gao
Pages: 9455-9466
Published online: 06 Apr 2022
AbstractforRole of sirtuin 1 in the brain development in congenital hypothyroidism rats via the regulation of p53 signaling pathway | Full Text | References | PDF (7.4 MB) | EPUB | Supplemental
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Article
Downregulation of Low-density lipoprotein receptor-related protein 1B (LRP1B) inhibits the progression of hepatocellular carcinoma cells by activating the endoplasmic reticulum stress signaling pathway
Zili Zhen, Zhemin Shen & Peilong Sun
Pages: 9467-9481
Published online: 07 Apr 2022
AbstractforDownregulation of Low-density lipoprotein receptor-related protein 1B (LRP1B) inhibits the progression of hepatocellular carcinoma cells by activating the endoplasmic reticulum stress signaling pathway | Full Text | References | PDF (7.6 MB) | EPUB | Supplemental
  • 1338 Views
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Article
Kruppel like factor 16 promotes lung adenocarcinoma progression by upregulating lamin B2
Xiaodan Jiao, Weinian Gao, Hongxin Ren, Yanning Wu, Tiezhi Li, Shujun Li & Hongjiang Yan
Pages: 9483-9495
Published online: 07 Apr 2022
AbstractforKruppel like factor 16 promotes lung adenocarcinoma progression by upregulating lamin B2 | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
  • 969 Views
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Article
Kinetochore-associated protein 1 promotes the invasion and tumorigenicity of cervical cancer cells via matrix metalloproteinase-2 and matrix metalloproteinase-9
Caimei Wang, Yiyuan Wang, Congrong Liu, Xiaoyu Meng & Zhongxia Hang
Pages: 9495-9507
Published online: 07 Apr 2022
AbstractforKinetochore-associated protein 1 promotes the invasion and tumorigenicity of cervical cancer cells via matrix metalloproteinase-2 and matrix metalloproteinase-9 | Full Text | References | PDF (3.3 MB) | EPUB
  • 1355 Views
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Review

Review Article
Genetic modifications associated with sustainability aspects for sustainable developments
Pooja Sharma, Surendra Pratap Singh, Hafiz M.N. Iqbal, Roberto Parra-Saldivar, Sunita Varjani & Yen Wah Tong
Pages: 9509-9521
Published online: 07 Apr 2022
AbstractforGenetic modifications associated with sustainability aspects for sustainable developments | Full Text | References | PDF (1.9 MB) | EPUB
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Review Article
An overview of microalgae biomass as a sustainable aquaculture feed ingredient: food security and circular economy
Ashfaq Ahmad, Shadi W. Hassan & Fawzi Banat
Pages: 9521-9547
Published online: 07 Apr 2022
AbstractforAn overview of microalgae biomass as a sustainable aquaculture feed ingredient: food security and circular economy | Full Text | References | PDF (2.2 MB) | EPUB
  • 11835 Views
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Article
Emodin suppresses hepatocellular carcinoma growth by regulating macrophage polarization via microRNA-26a/transforming growth factor beta 1/protein kinase B
Jiao Yin, Xiansheng Zhao, Xuejiao Chen & Guanxin Shen
Pages: 9549-9564
Published online: 07 Apr 2022
AbstractforEmodin suppresses hepatocellular carcinoma growth by regulating macrophage polarization via microRNA-26a/transforming growth factor beta 1/protein kinase B | Full Text | References | PDF (6.4 MB) | EPUB
  • 1581 Views
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Article
Transplantation of umbilical cord blood-derived mesenchymal stem cells as therapy for adriamycin induced-cardiomyopathy
Jingyue Zhang, Shiheng Zhang, Yueming Yang & Ling Liu
Pages: 9564-9574
Published online: 07 Apr 2022
AbstractforTransplantation of umbilical cord blood-derived mesenchymal stem cells as therapy for adriamycin induced-cardiomyopathy | Full Text | References | PDF (3.8 MB) | EPUB
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Article
Oncogenic magnesium transporter 1 upregulates programmed death-1-ligand 1 expression and contributes to growth and radioresistance of glioma cells through the ERK/MAPK signaling pathway
Yuanyuan Wu, Hongbing Wang & Dongdong Wei
Pages: 9575-9587
Published online: 13 Apr 2022
AbstractforOncogenic magnesium transporter 1 upregulates programmed death-1-ligand 1 expression and contributes to growth and radioresistance of glioma cells through the ERK/MAPK signaling pathway | Full Text | References | PDF (5.6 MB) | EPUB | Supplemental
  • 1279 Views
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Article
Melatonin promotes apoptosis of thyroid cancer cells via regulating the signaling of microRNA-21 (miR-21) and microRNA-30e (miR-30e)
Hao Jia, Wei Sun, Xiangbo Li & Wenhao Xu
Pages: 9588-9601
Published online: 12 Apr 2022
AbstractforMelatonin promotes apoptosis of thyroid cancer cells via regulating the signaling of microRNA-21 (miR-21) and microRNA-30e (miR-30e) | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Article
Long non-coding RNA Linc01133 promotes osteogenic differentiation of human periodontal ligament stem cells via microRNA-30c / bone gamma-carboxyglutamate protein axis
Qiang Li, Hangyu Zhou, Chuan Wang & Zhibin Zhu
Pages: 9603-9613
Published online: 17 Apr 2022
AbstractforLong non-coding RNA Linc01133 promotes osteogenic differentiation of human periodontal ligament stem cells via microRNA-30c / bone gamma-carboxyglutamate protein axis | Full Text | References | PDF (9.2 MB) | EPUB
  • 925 Views
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Article
MicroRNA-642b-3p functions as an oncomiR in gastric cancer by down-regulating the CUB and sushi multiple domains protein 1/smad axis
Haofeng Liu, Yuan Chen, Linsen Zhou, Xiaohui Jiang & Xiaojun Zhou
Pages: 9614-9628
Published online: 12 Apr 2022
AbstractforMicroRNA-642b-3p functions as an oncomiR in gastric cancer by down-regulating the CUB and sushi multiple domains protein 1/smad axis | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
  • 958 Views
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Article
Oxycodone protects cardiac microvascular endothelial cells against ischemia/reperfusion injury by binding to Sigma-1 Receptor
Meihua Ji, Jing Cheng & Daimin Zhang
Pages: 9628-9644
Published online: 12 Apr 2022
AbstractforOxycodone protects cardiac microvascular endothelial cells against ischemia/reperfusion injury by binding to Sigma-1 Receptor | Full Text | References | PDF (10.1 MB) | EPUB | Supplemental
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Review

Review Article
Comprehensive review on biotechnological production of hyaluronic acid: status, innovation, market and applications
Ruschoni Ucm, Mera Aem, Zamudio Lhb, Vinod Kumar, Mohammad J. Taherzadeh, Vijay Kumar Garlapati & Anuj Kumar Chandel
Pages: 9645-9661
Published online: 18 Apr 2022
AbstractforComprehensive review on biotechnological production of hyaluronic acid: status, innovation, market and applications | Full Text | References | PDF (4.6 MB) | EPUB
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Article
Circular RNA circ_0004277 Inhibits Acute Myeloid Leukemia Progression Through MicroRNA-134-5p / Single stranded DNA binding protein 2
Yao Liu, Xi Chen, Jingyang Liu, Yinglan Jin & Wei Wang
Pages: 9662-9673
Published online: 12 Apr 2022
AbstractforCircular RNA circ_0004277 Inhibits Acute Myeloid Leukemia Progression Through MicroRNA-134-5p / Single stranded DNA binding protein 2 | Full Text | References | PDF (2.6 MB) | EPUB
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Article
The role of Sirt6 in osteoarthritis and its effect on macrophage polarization
Jinwei Chen, Sichun Chen, Dawei Cai, Qiugen Wang & Jian Qin
Pages: 9677-9689
Published online: 21 Apr 2022
AbstractforThe role of Sirt6 in osteoarthritis and its effect on macrophage polarization | Full Text | References | PDF (3.4 MB) | EPUB
  • 3208 Views
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Article
Protective effect of growth differentiation factor 15 in sepsis by regulating macrophage polarization and its mechanism
Xinliang Zhang & Shimin Dong
Pages: 9687-9707
Published online: 14 Apr 2022
AbstractforProtective effect of growth differentiation factor 15 in sepsis by regulating macrophage polarization and its mechanism | Full Text | References | PDF (4.3 MB) | EPUB
  • 1881 Views
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Article
miR-129-5p targets FEZ1/SCOC/ULK1/NBR1 complex to restore neuronal function in mice with post-stroke depression
Fan Qinlin, Wang Bingqiao, Hu Linlin, Shi Peixia, Xie Lexing, Yang Lijun & Yang Qingwu
Pages: 9708-9728
Published online: 17 Apr 2022
AbstractformiR-129-5p targets FEZ1/SCOC/ULK1/NBR1 complex to restore neuronal function in mice with post-stroke depression | Full Text | References | PDF (22 MB) | EPUB
  • 1462 Views
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Article
Circular RNA Eps15-homology domain-containing protein 2 induce resistance of renal cell carcinoma to sunitinib via microRNA-4731-5p/ABCF2 axis
Wen Li, GaiXia Li & LuQuan Cao
Pages: 9729-9740
Published online: 12 Apr 2022
AbstractforCircular RNA Eps15-homology domain-containing protein 2 induce resistance of renal cell carcinoma to sunitinib via microRNA-4731-5p/ABCF2 axis | Full Text | References | PDF (6.5 MB) | EPUB
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Article
Suppression of bone remodeling associated with long-term bisphosphonate treatment is mediated by microRNA-30a-5p
Xia Li, Ruisheng Xu, Jun-Xing Ye & Feng-Lai Yuan
Pages: 9741-9753
Published online: 12 Apr 2022
AbstractforSuppression of bone remodeling associated with long-term bisphosphonate treatment is mediated by microRNA-30a-5p | Full Text | References | PDF (6.1 MB) | EPUB | Supplemental
  • 900 Views
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Article
Tumor targetable and pH-sensitive polymer nanoparticles for simultaneously improve the Type 2 Diabetes Mellitus and malignant breast cancer
Shi Tang, Peiqi Wen, Kaiheng Li, Jiehua Deng & Bo Yang
Pages: 9757-9768
Published online: 12 Apr 2022
AbstractforTumor targetable and pH-sensitive polymer nanoparticles for simultaneously improve the Type 2 Diabetes Mellitus and malignant breast cancer | Full Text | References | PDF (1.7 MB) | EPUB
  • 1308 Views
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Article
circHIPK3 regulates cell proliferation and migration by sponging microRNA-124 and regulating serine/threonine kinase 3 expression in esophageal squamous cell carcinoma
Da Yao, Shengcheng Lin, Size Chen & Zhe Wang
Pages: 9767-9780
Published online: 21 Apr 2022
AbstractforcircHIPK3 regulates cell proliferation and migration by sponging microRNA-124 and regulating serine/threonine kinase 3 expression in esophageal squamous cell carcinoma | Full Text | References | PDF (9.1 MB) | EPUB | Supplemental
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Article
Matrine impedes colorectal cancer proliferation and migration by downregulating endoplasmic reticulum lipid raft associated protein 1 expression
Hongtao Ren, Yali Wang, Ya Guo, Mincong Wang, Xiulong Ma, Wen Li, Yuyan Guo & Yiming Li
Pages: 9780-9791
Published online: 12 Apr 2022
AbstractforMatrine impedes colorectal cancer proliferation and migration by downregulating endoplasmic reticulum lipid raft associated protein 1 expression | Full Text | References | PDF (2.9 MB) | EPUB
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Article
Long non-coding RNA DHRS4 antisense RNA 1 inhibits ectopic endometrial cell proliferation, migration, and invasion in endometriosis by regulating microRNA-139-5p expression
Xuan Cui, Shisan Zhou & Yongtao Lin
Pages: 9792-9804
Published online: 12 Apr 2022
AbstractforLong non-coding RNA DHRS4 antisense RNA 1 inhibits ectopic endometrial cell proliferation, migration, and invasion in endometriosis by regulating microRNA-139-5p expression | Full Text | References | PDF (9.2 MB) | EPUB | Supplemental
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Article
Discoidin domain receptor 1a (DDR1a) confers 5-fluorouracil cytotoxicity in LoVo cell via PI3K/AKT/Bcl-2 pathway
Bin Xiong, Fei-Xue Song, Hui-Ling Chen, Xiao-Juan Wang, Zheng-Xu Jin, Ti-Yun Han, Yi Li & De-Kui Zhang
Pages: 9805-9814
Published online: 13 Apr 2022
AbstractforDiscoidin domain receptor 1a (DDR1a) confers 5-fluorouracil cytotoxicity in LoVo cell via PI3K/AKT/Bcl-2 pathway | Full Text | References | PDF (2.9 MB) | EPUB
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Review

Review Article
Bioprospecting and biotechnological insights into sweet-tasting proteins by microbial hosts―a review
Muhammad Bilal, Liyun Ji, Shuo Xu, Yue Zhang, Hafiz M. N. Iqbal & Hairong Cheng
Pages: 9816-9829
Published online: 17 Apr 2022
AbstractforBioprospecting and biotechnological insights into sweet-tasting proteins by microbial hosts―a review | Full Text | References | PDF (3.5 MB) | EPUB
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Research Paper

Article
Knockdown of lncRNA ACTA2-AS1 reverses cisplatin resistance of ovarian cancer cells via inhibition of miR-378a-3p-regulated Wnt5a
Chenxiao Lin, Meiyun Zheng, Youlin Yang, Yi Chen, Xiahui Zhang, Lingping Zhu & Haiyan Zhang
Pages: 9829-9838
Published online: 12 Apr 2022
AbstractforKnockdown of lncRNA ACTA2-AS1 reverses cisplatin resistance of ovarian cancer cells via inhibition of miR-378a-3p-regulated Wnt5a | Full Text | References | PDF (5.2 MB) | EPUB
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Article
Identifying the shared genes and KEGG pathways of Resolvin D1-targeted network and osteoarthritis using bioinformatics
Wenjun Jiang, Xiaoying Wang, Siwei Su, Sen Du & Hongqiang Song
Pages: 9839-9854
Published online: 18 Apr 2022
AbstractforIdentifying the shared genes and KEGG pathways of Resolvin D1-targeted network and osteoarthritis using bioinformatics | Full Text | References | PDF (11.4 MB) | EPUB | Supplemental
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Article
Calcium-binding protein 39 overexpression promotes macrophages from ‘M1’ into ‘M2’ phenotype and improves chondrocyte damage in osteoarthritis by activating the AMP-activated protein kinase/sirtuin 1 axis
Qiuliang Liu, Kai Pian, Zhen Tian, Haitao Duan, Qi Wang, Hui Zhang, Longyan Shi & Dongjian Song
Pages: 9855-9871
Published online: 12 Apr 2022
AbstractforCalcium-binding protein 39 overexpression promotes macrophages from ‘M1’ into ‘M2’ phenotype and improves chondrocyte damage in osteoarthritis by activating the AMP-activated protein kinase/sirtuin 1 axis | Full Text | References | PDF (4.2 MB) | EPUB
  • 2175 Views
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Article
Long non-coding RNAs PGM5-AS1 upregulates Decorin (DCN) to inhibit cervical cancer progression by sponging miR-4284
Huimin Wang, Dan Wang, Qiong Wei, Chun Li, Chunyan Li & Jing Yang
Pages: 9872-9884
Published online: 14 Apr 2022
AbstractforLong non-coding RNAs PGM5-AS1 upregulates Decorin (DCN) to inhibit cervical cancer progression by sponging miR-4284 | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 1200 Views
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Article
Research and experimental verification of the molecular mechanism of berberine in improving premature ovarian failure based on network pharmacology
Wu Xue, Fan Xue, Tao Jia & Ai Hao
Pages: 9885-9900
Published online: 14 Apr 2022
AbstractforResearch and experimental verification of the molecular mechanism of berberine in improving premature ovarian failure based on network pharmacology | Full Text | References | PDF (13.1 MB) | EPUB | Supplemental
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Article
Human umbilical cord mesenchymal stromal cells promotes the proliferation and osteogenic differentiation of autologous bone marrow stem cells by secreting exosomes
Yao Hai, Cao Zhidong & Wu Wenyan
Pages: 9901-9915
Published online: 12 Apr 2022
AbstractforHuman umbilical cord mesenchymal stromal cells promotes the proliferation and osteogenic differentiation of autologous bone marrow stem cells by secreting exosomes | Full Text | References | PDF (6.7 MB) | EPUB
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Article
Proteomics identifies new potential therapeutic targets of diabetic retinopathy
Huanran Zhou, Qian Xu, Hongxue Li, Yuxin Hu & Hongyu Kuang
Pages: 9916-9927
Published online: 12 Apr 2022
AbstractforProteomics identifies new potential therapeutic targets of diabetic retinopathy | Full Text | References | PDF (8 MB) | EPUB | Supplemental
  • 1555 Views
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Article
Sp1 transcription factor represses transcription of phosphatase and tensin homolog to aggravate lung injury in mice with type 2 diabetes mellitus-pulmonary tuberculosis
Hongmei Zhao, Lian Shi, Xiaohong Wang, Xiuli Yu & Danfeng Wang
Pages: 9928-9944
Published online: 14 Apr 2022
AbstractforSp1 transcription factor represses transcription of phosphatase and tensin homolog to aggravate lung injury in mice with type 2 diabetes mellitus-pulmonary tuberculosis | Full Text | References | PDF (8.1 MB) | EPUB | Supplemental
  • 1198 Views
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Article
Identification of differential microRNAs and messenger RNAs resulting from ASXL transcriptional regulator 3 knockdown during during heart development
Ze-Qun Liu, Mi Cheng, Fang Fu, Ru Li, Jin Han, Xin Yang, Qiong Deng, Lu-Shan Li, Ting-Ying Lei, Dong-Zhi Li & Can Liao
Pages: 9948-9961
Published online: 17 Apr 2022
AbstractforIdentification of differential microRNAs and messenger RNAs resulting from ASXL transcriptional regulator 3 knockdown during during heart development | Full Text | References | PDF (6.6 MB) | EPUB | Supplemental
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Article
MicroRNA-18 facilitates the stemness of gastric cancer by downregulating HMGB3 though targeting Meis2
Yingjun Zhang, Weijian Lin, Weiping Jiang & Zhenfa Wang
Pages: 9959-9972
Published online: 13 Apr 2022
AbstractforMicroRNA-18 facilitates the stemness of gastric cancer by downregulating HMGB3 though targeting Meis2 | Full Text | References | PDF (5.9 MB) | EPUB
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Article
Quercetin inhibits fibroblasts proliferation and reduces surgery-induced epidural fibrosis via the autophagy-mediated PI3K/Akt/mTOR pathway
Yile Cao, Hui Chen, Yu Sun, Zhehao Fan & Hong Cheng
Pages: 9973-9986
Published online: 12 Apr 2022
AbstractforQuercetin inhibits fibroblasts proliferation and reduces surgery-induced epidural fibrosis via the autophagy-mediated PI3K/Akt/mTOR pathway | Full Text | References | PDF (6 MB) | EPUB
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Article
Long intergenic non-protein coding RNA 847 promotes laryngeal squamous cell carcinoma progression through the microRNA-181a-5p/zinc finger E-box binding homeobox 2 axis
Wei Li, Xionghui Hu & Xiaolin Huang
Pages: 9987-10000
Published online: 17 Apr 2022
AbstractforLong intergenic non-protein coding RNA 847 promotes laryngeal squamous cell carcinoma progression through the microRNA-181a-5p/zinc finger E-box binding homeobox 2 axis | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 924 Views
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Article
lncRNA LINC01315 promotes malignancy of triple-negative breast cancer and predicts poor outcomes by modulating microRNA-876-5p/GRK5
Yan Xiu, Shannan Cao, Ru Jiang & Yuming Zhou
Pages: 10001-10009
Published online: 12 Apr 2022
AbstractforlncRNA LINC01315 promotes malignancy of triple-negative breast cancer and predicts poor outcomes by modulating microRNA-876-5p/GRK5 | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Article
Bacterial Cellulose Production from agricultural Residues by two Komagataeibacter sp. Strains
Moyinoluwa O. Akintunde, Bukola C. Adebayo-Tayo, Mofoluwake M. Ishola, Akram Zamani & Ilona Sárvári Horváth
Pages: 10010-10025
Published online: 13 Apr 2022
AbstractforBacterial Cellulose Production from agricultural Residues by two Komagataeibacter sp. Strains | Full Text | References | PDF (4.6 MB) | EPUB
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Article
Long non-coding RNA NRAV enhances proliferation and invasion of hepatocellular carcinoma cells by modulating the Wnt/β-catenin signaling pathway
Qingxian Wang, Yumei Tang, Yuansen Ge, Songming Zhang & Meiyuan Zheng
Pages: 10026-10037
Published online: 18 Apr 2022
AbstractforLong non-coding RNA NRAV enhances proliferation and invasion of hepatocellular carcinoma cells by modulating the Wnt/β-catenin signaling pathway | Full Text | References | PDF (4.4 MB) | EPUB
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Article
Endothelium-dependent vasorelaxant effects of praeruptorin a in isolated rat thoracic aorta
Zhenkun Li, Fengrong Zhang, Shicong Wang, Honghe Xiao, Jingyi Wang, Xianyu Li & Hongjun Yang
Pages: 10038-10046
Published online: 13 Apr 2022
AbstractforEndothelium-dependent vasorelaxant effects of praeruptorin a in isolated rat thoracic aorta | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Cleavage stimulation factor 2 promotes malignant progression of liver hepatocellular carcinoma by activating phosphatidylinositol 3′-kinase/protein kinase B/mammalian target of rapamycin pathway
Meng-Hui Zhang & Jun Liu
Pages: 10047-10060
Published online: 12 Apr 2022
AbstractforCleavage stimulation factor 2 promotes malignant progression of liver hepatocellular carcinoma by activating phosphatidylinositol 3′-kinase/protein kinase B/mammalian target of rapamycin pathway | Full Text | References | PDF (17.1 MB) | EPUB
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Article
MicroRNA-218-5p affects lung adenocarcinoma progression through targeting endoplasmic reticulum oxidoreductase 1 alpha
Gang Chen, Qihao Wang & Kunyu Wang
Pages: 10061-10070
Published online: 20 Apr 2022
AbstractforMicroRNA-218-5p affects lung adenocarcinoma progression through targeting endoplasmic reticulum oxidoreductase 1 alpha | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Article
SIA-IgG confers poor prognosis and represents a novel therapeutic target in breast cancer
Man Zhang, Jinhua Zheng, Junying Guo, Qiujin Zhang, Juan Du, Xiangfeng Zhao, Zhihua Wang & Qinyuan Liao
Pages: 10072-10087
Published online: 26 Apr 2022
AbstractforSIA-IgG confers poor prognosis and represents a novel therapeutic target in breast cancer | Full Text | References | PDF (12.7 MB) | EPUB | Supplemental
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Article
Simple and robust 3D bioprinting of full-thickness human skin tissue
Jing Liu, Zhengtong Zhou, Min Zhang, Feng Song, Chong Feng & Haochen Liu
Pages: 10090-10100
Published online: 12 Apr 2022
AbstractforSimple and robust 3D bioprinting of full-thickness human skin tissue | Full Text | References | PDF (6.8 MB) | EPUB
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Article
Adiponectin inhibits the activation of lung fibroblasts and pulmonary fibrosis by regulating the nuclear factor kappa B (NF-κB) pathway
Xin Wang, Jian Yang, Liangquan Wu, Chunran Tong, Ying Zhu, Wei Cai, Bing Wan & Xiuwei Zhang
Pages: 10098-10110
Published online: 17 Apr 2022
AbstractforAdiponectin inhibits the activation of lung fibroblasts and pulmonary fibrosis by regulating the nuclear factor kappa B (NF-κB) pathway | Full Text | References | PDF (5.5 MB) | EPUB
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Article
Astragaloside IV exhibits anti-tumor function in gastric cancer via targeting circRNA dihydrolipoamide S-succinyltransferase (circDLST)/miR-489-3p/ eukaryotic translation initiation factor 4A1(EIF4A1) pathway
Fagen Li, Ke Cao, Maoyun Wang, Yi Liu & Yin Zhang
Pages: 10112-10123
Published online: 17 Apr 2022
AbstractforAstragaloside IV exhibits anti-tumor function in gastric cancer via targeting circRNA dihydrolipoamide S-succinyltransferase (circDLST)/miR-489-3p/ eukaryotic translation initiation factor 4A1(EIF4A1) pathway | Full Text | References | PDF (6.4 MB) | EPUB
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Article
Plasmacytoma variant translocation 1 stabilized by EIF4A3 promoted malignant biological behaviors of lung adenocarcinoma by generating circular RNA LMNB2
Minglian Qiu, Meizhen Chen, Zhongping Lan, Bo Liu, Jinbao Xie & Xu Li
Pages: 10123-10140
Published online: 17 Apr 2022
AbstractforPlasmacytoma variant translocation 1 stabilized by EIF4A3 promoted malignant biological behaviors of lung adenocarcinoma by generating circular RNA LMNB2 | Full Text | References | PDF (17.6 MB) | EPUB | Supplemental
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Article
Peptide YY 3–36 attenuates trinitrobenzene sulfonic acid-induced colitis in mice by modulating Th1/Th2 differentiation
Zhiqiang Li, Xiaoyuan Kuang, Tao Chen, Tao Shen & Jiahong Wu
Pages: 10144-10158
Published online: 20 Apr 2022
AbstractforPeptide YY 3–36 attenuates trinitrobenzene sulfonic acid-induced colitis in mice by modulating Th1/Th2 differentiation | Full Text | References | PDF (5.4 MB) | EPUB
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Article
Dexmedetomidine promotes cell proliferation and inhibits cell apoptosis by regulating LINC00982 and activating the phosphoinositide-3-kinase (PI3K)/protein kinase B (AKT) signaling in hypoxia/reoxygenation-induced H9c2 cells
Tao Wang, Zhen Li, Shuyun Xia, Zhixin Xu, Xiaofang Chen & Hu Sun
Pages: 10159-10167
Published online: 24 Apr 2022
AbstractforDexmedetomidine promotes cell proliferation and inhibits cell apoptosis by regulating LINC00982 and activating the phosphoinositide-3-kinase (PI3K)/protein kinase B (AKT) signaling in hypoxia/reoxygenation-induced H9c2 cells | Full Text | References | PDF (3.2 MB) | EPUB
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Article
Circular RNA circ_0067741 regulates the Hippo/YAP pathway to suppress lung adenocarcinoma progression by targeting microRNA-183-5p
Jianming Mo, Hao Nie, Chao Zeng, Hui Han, Ping Xu & Xingyuan Shi
Pages: 10165-10176
Published online: 17 Apr 2022
AbstractforCircular RNA circ_0067741 regulates the Hippo/YAP pathway to suppress lung adenocarcinoma progression by targeting microRNA-183-5p | Full Text | References | PDF (4.2 MB) | EPUB
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Article
CTSV (cathepsin V) promotes bladder cancer progression by increasing NF-κB activity
Yue Xia, Minghuan Ge, Ling Xia, Guang Shan & Huijun Qian
Pages: 10180-10190
Published online: 20 Apr 2022
AbstractforCTSV (cathepsin V) promotes bladder cancer progression by increasing NF-κB activity | Full Text | References | PDF (3 MB) | EPUB
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Article
CircSETD3 (hsa_circ_0000567) inhibits proliferation and induces apoptosis in cholangiocarcinoma cells via downregulation of microRNA-421 expression
Wei Xiong, Aiqing Zhang, Xiuli Xiao & Wenjuan Liu
Pages: 10191-10201
Published online: 17 Apr 2022
AbstractforCircSETD3 (hsa_circ_0000567) inhibits proliferation and induces apoptosis in cholangiocarcinoma cells via downregulation of microRNA-421 expression | Full Text | References | PDF (4.2 MB) | EPUB
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Article
U2 small nuclear RNA auxiliary factor 2, transcriptionally activated by the transcription factor Dp-1/E2F transcription factor 1 complex, enhances the growth and aerobic glycolysis of leiomyosarcoma cells
Yuguo Li, Sihao Chen, Xin Zhang & Naiqiang Zhuo
Pages: 10200-10212
Published online: 03 May 2022
AbstractforU2 small nuclear RNA auxiliary factor 2, transcriptionally activated by the transcription factor Dp-1/E2F transcription factor 1 complex, enhances the growth and aerobic glycolysis of leiomyosarcoma cells | Full Text | References | PDF (6.7 MB) | EPUB | Supplemental
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Article
Long non-coding RNA-small nucleolar RNA host gene 7 regulates inflammatory responses following spinal cord injury by regulating the microRNA-449a/TNF-α-induced protein 3-interacting protein 2 axis
Chunlei He, Jianhua Xiao, Yongjun Ye, Shiqiao Huang, Yanchun Zhong, Lulin Liu, Wuyang Liu & Sheng Liu
Pages: 10215-10226
Published online: 20 Apr 2022
AbstractforLong non-coding RNA-small nucleolar RNA host gene 7 regulates inflammatory responses following spinal cord injury by regulating the microRNA-449a/TNF-α-induced protein 3-interacting protein 2 axis | Full Text | References | PDF (6.6 MB) | EPUB
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Retracted Article

Article
RETRACTED ARTICLE: PSB0788 ameliorates maternal inflammation‐induced periventricular leukomalacia-like injury
Yilu Li, Dan Wang, Zhuoyang Li & Zhi Ouyang
Pages: 10224-10234
Published online: 18 Apr 2022
AbstractforRETRACTED ARTICLE: PSB0788 ameliorates maternal inflammation‐induced periventricular leukomalacia-like injury | PDF (13 MB)
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Research Paper

Article
Protective effects of asiaticoside on renal ischemia reperfusion injury in vivo and in vitro
Shengjie Tang, Xiangcheng Xie, Ming Wang, Lili Yang & Wei Wei
Pages: 10235-10243
Published online: 17 Apr 2022
AbstractforProtective effects of asiaticoside on renal ischemia reperfusion injury in vivo and in vitro | Full Text | References | PDF (1.5 MB) | EPUB
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Article
Yin Yang 1-stimulated long noncoding RNA bladder cancer-associated transcript 1 upregulation facilitates esophageal carcinoma progression via the microRNA-5590-3p/programmed cell death-ligand 1 pathway
Jingge Cheng, Qian Yang, Xia Han, Haotian Wang, Kun Wu & Hongye Zhao
Pages: 10244-10257
Published online: 17 Apr 2022
AbstractforYin Yang 1-stimulated long noncoding RNA bladder cancer-associated transcript 1 upregulation facilitates esophageal carcinoma progression via the microRNA-5590-3p/programmed cell death-ligand 1 pathway | Full Text | References | PDF (5.6 MB) | EPUB | Supplemental
  • 957 Views
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Article
CircRNA CTNNB1 (circCTNNB1) ameliorates cerebral ischemia/reperfusion injury by sponging miR-96-5p to up-regulate scavenger receptor class B type 1 (SRB1) expression
Chun Chen, Xiaolong Chang, Shifei Zhang, Qi Zhao & Chunyan Lei
Pages: 10258-10273
Published online: 17 Apr 2022
AbstractforCircRNA CTNNB1 (circCTNNB1) ameliorates cerebral ischemia/reperfusion injury by sponging miR-96-5p to up-regulate scavenger receptor class B type 1 (SRB1) expression | Full Text | References | PDF (4 MB) | EPUB
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Article
LncRNA growth arrest specific transcript 5 inhibits the growth of pituitary neuroendocrine tumors via miR-27a-5p/cylindromatosis axis
Heyuan Wang, Bing Wu, Haotian Wang, Chunyan Jiang & Zhonghui Liu
Pages: 10274-10286
Published online: 17 Apr 2022
AbstractforLncRNA growth arrest specific transcript 5 inhibits the growth of pituitary neuroendocrine tumors via miR-27a-5p/cylindromatosis axis | Full Text | References | PDF (7.7 MB) | EPUB | Supplemental
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Article
MicroRNA-103a-3p enhances sepsis-induced acute kidney injury via targeting CXCL12
Gaihong Ding, Jinhua an & Luyao Li
Pages: 10288-10298
Published online: 05 May 2022
AbstractforMicroRNA-103a-3p enhances sepsis-induced acute kidney injury via targeting CXCL12 | Full Text | References | PDF (5.3 MB) | EPUB
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Article
Electroacupuncture improves endometrial receptivity through miRNA-223-3p-mediated regulation of leukemia inhibitory factor / signal transducer and activator of transcription 3 signaling pathway
Fang You, Xin Du, Taiwei Zhang, Yang Wang, Yuxia Lv & Li Zeng
Pages: 10298-10312
Published online: 17 Apr 2022
AbstractforElectroacupuncture improves endometrial receptivity through miRNA-223-3p-mediated regulation of leukemia inhibitory factor / signal transducer and activator of transcription 3 signaling pathway | Full Text | References | PDF (5.8 MB) | EPUB
  • 1435 Views
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Article
Wnt10b-overexpressing umbilical cord mesenchymal stem cells promote fracture healing via accelerated cartilage callus to bone remodeling
Yuxiang Hu, Yu He, Jiarui Fang, Yunlu Liu, Yulin Cao, Wei Tong, Wei Chen, Zengwu Shao, Yong Liu & Hongtao Tian
Pages: 10314-10324
Published online: 18 Apr 2022
AbstractforWnt10b-overexpressing umbilical cord mesenchymal stem cells promote fracture healing via accelerated cartilage callus to bone remodeling | Full Text | References | PDF (5.2 MB) | EPUB | Supplemental
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Article
Heat shock factor 2-binding protein promotes tumor progression via activation of MAPK signaling pathway in lung adenocarcinoma
Junyuan Liu, Yuting Zhang, Jie Tao, Tingting Yu & Tao Zhang
Pages: 10324-10334
Published online: 17 Apr 2022
AbstractforHeat shock factor 2-binding protein promotes tumor progression via activation of MAPK signaling pathway in lung adenocarcinoma | Full Text | References | PDF (4.5 MB) | EPUB
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Article
Circular RNA 0001823 aggravates the growth and metastasis of the cervical cancer cells through modulating the microRNA-613/RAB8A axis
Hong Ji & Naijun Hu
Pages: 10335-10349
Published online: 17 Apr 2022
AbstractforCircular RNA 0001823 aggravates the growth and metastasis of the cervical cancer cells through modulating the microRNA-613/RAB8A axis | Full Text | References | PDF (25.3 MB) | EPUB
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Article
Sulforaphane alleviates hypoxic vestibular vertigo (HVV) by increasing NO production via upregulating the expression of NRF2
Liyuan Zhou, Changchen Hu, Yujun Li & Binquan Wang
Pages: 10351-10361
Published online: 20 Apr 2022
AbstractforSulforaphane alleviates hypoxic vestibular vertigo (HVV) by increasing NO production via upregulating the expression of NRF2 | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
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Article
MiR-192 attenuates high glucose-induced pyroptosis in retinal pigment epithelial cells via inflammasome modulation
Cao Gu, Hongjun Zhang, Qing Li, Shaofei Zhao & Yu Gao
Pages: 10362-10372
Published online: 20 Apr 2022
AbstractforMiR-192 attenuates high glucose-induced pyroptosis in retinal pigment epithelial cells via inflammasome modulation | Full Text | References | PDF (3.5 MB) | EPUB
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Article
LINC00173 regulates polycystic ovarian syndrome progression by promoting apoptosis and repressing proliferation in ovarian granulosa cells via the microRNA-124-3p (miR-124-3p)/jagged canonical Notch ligand 1 (JAG1) pathway
Lan Chen & Caixia Kong
Pages: 10373-10385
Published online: 20 Apr 2022
AbstractforLINC00173 regulates polycystic ovarian syndrome progression by promoting apoptosis and repressing proliferation in ovarian granulosa cells via the microRNA-124-3p (miR-124-3p)/jagged canonical Notch ligand 1 (JAG1) pathway | Full Text | References | PDF (3.8 MB) | EPUB
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Article
Tribbles homolog 3 contributes to high glucose-induced injury in retinal pigment epithelial cells via binding to growth factor receptor-bound 2
Qin Liao & Xuefeng Gao
Pages: 10386-10398
Published online: 23 Apr 2022
AbstractforTribbles homolog 3 contributes to high glucose-induced injury in retinal pigment epithelial cells via binding to growth factor receptor-bound 2 | Full Text | References | PDF (7.7 MB) | EPUB
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Article
Silencing of LncRNA KCNQ1OT1 confers an inhibitory effect on renal fibrosis through repressing miR-124-3p activity
Jian Hao, Yun Zhou, Weimin Yu, Hui Li & Dandan He
Pages: 10399-10411
Published online: 21 Apr 2022
AbstractforSilencing of LncRNA KCNQ1OT1 confers an inhibitory effect on renal fibrosis through repressing miR-124-3p activity | Full Text | References | PDF (5.4 MB) | EPUB | Supplemental
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Review

Review Article
A comprehensive review on the use of algal-bacterial systems for wastewater treatment with emphasis on nutrient and micropollutant removal
Raj Kumar Oruganti, Keerthi Katam, Pau Loke Show, Venkataramana Gadhamshetty, Venkata Krishna Kumar Upadhyayula & Debraj Bhattacharyya
Pages: 10412-10453
Published online: 20 Apr 2022
AbstractforA comprehensive review on the use of algal-bacterial systems for wastewater treatment with emphasis on nutrient and micropollutant removal | Full Text | References | PDF (3.6 MB) | EPUB
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Research Paper

Article
LncRNA FLVCR1-AS1 mediates miR-23a-5p/SLC7A11 axis to promote malignant behavior of cervical cancer cells
Xi Zhou, Xia Zhao, ZhouYi Wu, Yan Ma & Heng Li
Pages: 10454-10466
Published online: 23 Apr 2022
AbstractforLncRNA FLVCR1-AS1 mediates miR-23a-5p/SLC7A11 axis to promote malignant behavior of cervical cancer cells | Full Text | References | PDF (7.2 MB) | EPUB
  • 1138 Views
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Article
Noncoding-RNA mediated high expression of zinc finger protein 268 suppresses clear cell renal cell carcinoma progression by promoting apoptosis and regulating immune cell infiltration
Keyi Wang, Yongzhe Gu, Jinliang Ni, Houliang Zhang, Yidi Wang, Yifan Zhang, Xianchao Sun, Tianyuan Xu, Weipu Mao & Bo Peng
Pages: 10467-10481
Published online: 23 Apr 2022
AbstractforNoncoding-RNA mediated high expression of zinc finger protein 268 suppresses clear cell renal cell carcinoma progression by promoting apoptosis and regulating immune cell infiltration | Full Text | References | PDF (5.2 MB) | EPUB | Supplemental
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Article
Fusion of a proline-rich oligopeptide to the C-terminus of a ruminal xylanase improves catalytic efficiency
Ruyue Dong, Xiaoqing Liu, Yaru Wang, Xing Qin, Xiaolu Wang, Honglian Zhang, Yuan Wang, Huiying Luo, Bin Yao, Yingguo Bai & Tao Tu
Pages: 10482-10492
Published online: 20 Apr 2022
AbstractforFusion of a proline-rich oligopeptide to the C-terminus of a ruminal xylanase improves catalytic efficiency | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Article
Methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit-induced long intergenic non-protein coding RNA 1833 N6-methyladenosine methylation promotes the non-small cell lung cancer progression via regulating heterogeneous nuclear ribonucleoprotein A2/B1 expression
Dongliang Li, Zejun Fu, Chaoqun Dong & Yongming Song
Pages: 10493-10503
Published online: 20 Apr 2022
AbstractforMethyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit-induced long intergenic non-protein coding RNA 1833 N6-methyladenosine methylation promotes the non-small cell lung cancer progression via regulating heterogeneous nuclear ribonucleoprotein A2/B1 expression | Full Text | References | PDF (9.8 MB) | EPUB | Supplemental
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Article
The interferon regulatory factor 6 promotes cisplatin sensitivity in colorectal cancer
Lin Tan, Weiming Qu, Dajun Wu, Minji Liu, Qiongjia Ai, Hongsai Hu, Qian Wang, Weishun Chen & Hongbing Zhou
Pages: 10504-10517
Published online: 20 Apr 2022
AbstractforThe interferon regulatory factor 6 promotes cisplatin sensitivity in colorectal cancer | Full Text | References | PDF (6.2 MB) | EPUB
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Review

Review Article
Mechano-chemical and biological energetics of immobilized enzymes onto functionalized polymers and their applications
Tanvi Sharma, Changlei Xia, Abhishek Sharma, Pankaj Raizada, Pardeep Singh, Swati Sharma, Pooja Sharma, Sunil Kumar, SuShiung Lam & Ashok Kumar Nadda
Pages: 10518-10539
Published online: 21 Apr 2022
AbstractforMechano-chemical and biological energetics of immobilized enzymes onto functionalized polymers and their applications | Full Text | References | PDF (5.7 MB) | EPUB
  • 2649 Views
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Research Paper

Report
Downregulation of fatty acid binding protein 4 alleviates lipid peroxidation and oxidative stress in diabetic retinopathy by regulating peroxisome proliferator-activated receptor γ-mediated ferroptosis
Xiao’e Fan, Manhong Xu, Qianfeng Ren, Yan Fan, Boshi Liu, Jiaqi Chen, Zhengmin Wang & Xiaoyan Sun
Pages: 10540-10551
Published online: 20 Apr 2022
AbstractforDownregulation of fatty acid binding protein 4 alleviates lipid peroxidation and oxidative stress in diabetic retinopathy by regulating peroxisome proliferator-activated receptor γ-mediated ferroptosis | Full Text | References | PDF (3.8 MB) | EPUB
  • 4763 Views
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Article
CircMYC promotes proliferation, migration, invasion and inhibits apoptosis of small cell lung cancer by targeting miR-145/ Matrix Metallopeptidase 2 axis
Xi Yang, Lianqin Tao, Yani Xu, Sujian Li, Weiwei Yang, Lijuan Wang & Junfei Zhu
Pages: 10552-10563
Published online: 20 Apr 2022
AbstractforCircMYC promotes proliferation, migration, invasion and inhibits apoptosis of small cell lung cancer by targeting miR-145/ Matrix Metallopeptidase 2 axis | Full Text | References | PDF (4.1 MB) | EPUB
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Article
Inhibition of endoplasmic reticulum stress alleviates triple-negative breast cancer cell viability, migration, and invasion by Syntenin/SOX4/Wnt/β-catenin pathway via regulation of heat shock protein A4
Jinniang Nan, Xuguang Hu, Binbin Guo, Meiyun Xu & Yufeng Yao
Pages: 10564-10577
Published online: 20 Apr 2022
AbstractforInhibition of endoplasmic reticulum stress alleviates triple-negative breast cancer cell viability, migration, and invasion by Syntenin/SOX4/Wnt/β-catenin pathway via regulation of heat shock protein A4 | Full Text | References | PDF (8.7 MB) | EPUB
  • 1821 Views
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Article
CircRNA circ_0023984 promotes the progression of esophageal squamous cell carcinoma via regulating miR-134-5p/cystatin-s axis
Ge Yang, Yu Zhang, Hongni Lin, Jinnbo Liu, Shengjie Huang, Wei Zhong, Chao Peng & Lin Du
Pages: 10578-10593
Published online: 20 Apr 2022
AbstractforCircRNA circ_0023984 promotes the progression of esophageal squamous cell carcinoma via regulating miR-134-5p/cystatin-s axis | Full Text | References | PDF (4.9 MB) | EPUB
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Article
Long non-coding MELTF Antisense RNA 1 promotes and prognosis the progression of non-small cell lung cancer by targeting miR-1299
Jin Chai, Li Qin, Guangxin Zhang, Peiyan Hua & Chengyan Jin
Pages: 10594-10604
Published online: 20 Apr 2022
AbstractforLong non-coding MELTF Antisense RNA 1 promotes and prognosis the progression of non-small cell lung cancer by targeting miR-1299 | Full Text | References | PDF (2.3 MB) | EPUB
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Article
The protective effects of cabozantinib against high glucose-induced damages in in vitro renal glomerular endothelial cells model via inhibition of early growth response-1 (Egr-1)
Hanlu Ye, Jingjing Yan, Qiong Wang, Hui Tian & Lei Zhou
Pages: 10605-10616
Published online: 20 Apr 2022
AbstractforThe protective effects of cabozantinib against high glucose-induced damages in in vitro renal glomerular endothelial cells model via inhibition of early growth response-1 (Egr-1) | Full Text | References | PDF (2.8 MB) | EPUB
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Article
The biological behavior of tRNA-derived fragment tRF-Leu-AAG in pancreatic cancer cells
Shizhen Sui, Zhihuai Wang, Xiaohan Cui, Lei Jin & Chunfu Zhu
Pages: 10617-10628
Published online: 20 Apr 2022
AbstractforThe biological behavior of tRNA-derived fragment tRF-Leu-AAG in pancreatic cancer cells | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
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Article
Family with sequence similarity 46 member a confers chemo-resistance to ovarian carcinoma via TGF-β/Smad2 signaling
Suiying Liang, Yueyang Liu, Jianhui He, Tian Gao, Lanying Li & Shanyang He
Pages: 10629-10639
Published online: 23 Apr 2022
AbstractforFamily with sequence similarity 46 member a confers chemo-resistance to ovarian carcinoma via TGF-β/Smad2 signaling | Full Text | References | PDF (8.6 MB) | EPUB | Supplemental
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Article
The potential mechanism of Fructus Ligustri Lucidi promoting osteogenetic differentiation of bone marrow mesenchymal stem cells based on network pharmacology, molecular docking and experimental identification
Yuanhang Kong, Xinnan Ma, Xin Zhang, Leilei Wu, Dechun Chen, Bo Su, Daqian Liu & Xintao Wang
Pages: 10640-10653
Published online: 27 Apr 2022
AbstractforThe potential mechanism of Fructus Ligustri Lucidi promoting osteogenetic differentiation of bone marrow mesenchymal stem cells based on network pharmacology, molecular docking and experimental identification | Full Text | References | PDF (16.4 MB) | EPUB | Supplemental
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Article
High expression of H2A histone family member Y promotes the proliferation and autophagy of hepatocellular carcinoma cells
Jiasheng Lei, Shuoshuo Ma, Wanliang Sun, Dongdong Wang, Zheng Lu & Dengyong Zhang
Pages: 10654-10664
Published online: 26 Apr 2022
AbstractforHigh expression of H2A histone family member Y promotes the proliferation and autophagy of hepatocellular carcinoma cells | Full Text | References | PDF (6.5 MB) | EPUB
  • 976 Views
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Article
Plin5 inhibits proliferation and migration of vascular smooth muscle cell through interacting with PGC-1α following vascular injury
Xueqing Gan, Jiaqi Zhao, Yingmei Chen, Yong Li, Bing Xuan, Min Gu, Feifei Feng, Yongjian Yang, Dachun Yang & Xiongshan Sun
Pages: 10665-10678
Published online: 26 Apr 2022
AbstractforPlin5 inhibits proliferation and migration of vascular smooth muscle cell through interacting with PGC-1α following vascular injury | Full Text | References | PDF (5.4 MB) | EPUB | Supplemental
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Article
The biological function of the long non-coding RNA endogenous born avirus-like nucleoprotein in lung adenocarcinoma is mediated through the microRNA-655-3p/B-cell lymphoma-2 axis
Xiaopeng Wang & Jing Yin
Pages: 10679-10690
Published online: 27 Apr 2022
AbstractforThe biological function of the long non-coding RNA endogenous born avirus-like nucleoprotein in lung adenocarcinoma is mediated through the microRNA-655-3p/B-cell lymphoma-2 axis | Full Text | References | PDF (5.2 MB) | EPUB | Supplemental
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Article
MiR-4733-5p promotes gallbladder carcinoma progression via directly targeting kruppel like factor 7
Xiaoqiang Hu, Junzhe Zhang, Junfeng Bu, Kaini Yang, Sunwang Xu, Mengqiao Pan, Dongxi Xiang & Wei Chen
Pages: 10691-10706
Published online: 21 Apr 2022
AbstractforMiR-4733-5p promotes gallbladder carcinoma progression via directly targeting kruppel like factor 7 | Full Text | References | PDF (6.4 MB) | EPUB | Supplemental
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Article
Long non-coding RNA MIR4435-2HG/microRNA-125a-5p axis is involved in myocardial ischemic injuries
Xiuling Wang, Lina Ren, Shuai Chen, Yanli Tao, Dandan Zhao & Chunwei Wu
Pages: 10707-10720
Published online: 27 Apr 2022
AbstractforLong non-coding RNA MIR4435-2HG/microRNA-125a-5p axis is involved in myocardial ischemic injuries | Full Text | References | PDF (13.9 MB) | EPUB
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Article
LINC01578 affects the radiation resistance of lung cancer cells through regulating microRNA-216b-5p/TBL1XR1 axis
Peirong Wang, Linchun Ke, Chuanshu Cai & Feng Dong
Pages: 10721-10733
Published online: 27 Apr 2022
AbstractforLINC01578 affects the radiation resistance of lung cancer cells through regulating microRNA-216b-5p/TBL1XR1 axis | Full Text | References | PDF (8.3 MB) | EPUB | Supplemental
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Article
CircMCTP2 (has-circ-0000658) facilitates the proliferation and metastasis of bladder carcinoma through modulating the miR-498/murine double minute-2 axis
Qiao Gu, Wenjie Hou, Lijuan Shi, Zonghao Zhu, Huan Liu & Xiaozhou He
Pages: 10734-10748
Published online: 27 Apr 2022
AbstractforCircMCTP2 (has-circ-0000658) facilitates the proliferation and metastasis of bladder carcinoma through modulating the miR-498/murine double minute-2 axis | Full Text | References | PDF (13.9 MB) | EPUB | Supplemental
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Article
Long noncoding RNA regulatory factor X3- antisense RNA 1 promotes non-small cell lung cancer via the microRNA-577/signal transducer and activator of transcription 3 axis
Yanjing Hu, Zhi Zhao, Gang Jin, Junhao Guo, Fangyuan Nan, Xin Hu, Yunsheng Hu & Qun Han
Pages: 10749-10764
Published online: 27 Apr 2022
AbstractforLong noncoding RNA regulatory factor X3- antisense RNA 1 promotes non-small cell lung cancer via the microRNA-577/signal transducer and activator of transcription 3 axis | Full Text | References | PDF (5.1 MB) | EPUB
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Article
Long non-coding RNA placenta‑specific protein 2 regulates the chemosensitivity of cancer cells to cisplatin in hepatocellular carcinoma (HCC) by sponging microRNA-96 to upregulate X-linked inhibitor of apoptosis protein
Huixiong Wang, Xin Zhang, Xiaoting Chen, Shengbin Zhang, Zhelin Yun, Qiang Gao, Haitao Sheng & Junjie Wang
Pages: 10765-10773
Published online: 27 Apr 2022
AbstractforLong non-coding RNA placenta‑specific protein 2 regulates the chemosensitivity of cancer cells to cisplatin in hepatocellular carcinoma (HCC) by sponging microRNA-96 to upregulate X-linked inhibitor of apoptosis protein | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
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Article
Protective effect of miR-33-5p on the M1/M2 polarization of microglia and the underlying mechanism
Song Chai, Yilan Sheng, Ran Sun, Jieshi He, Lihua Chen, Fei He, Wenhua Chen, Dingying Ma & Bo Yu
Pages: 10774-10785
Published online: 29 Apr 2022
AbstractforProtective effect of miR-33-5p on the M1/M2 polarization of microglia and the underlying mechanism | Full Text | References | PDF (5.4 MB) | EPUB
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Article
Suppression of lncRNA Gm47283 attenuates myocardial infarction via miR-706/ Ptgs2/ferroptosis axis
Feng Gao, Yongcheng Zhao, Bin Zhang, Chunwei Xiao, Zhanfa Sun, Yuan Gao & Xueyong Dou
Pages: 10786-10802
Published online: 29 Apr 2022
AbstractforSuppression of lncRNA Gm47283 attenuates myocardial infarction via miR-706/ Ptgs2/ferroptosis axis | Full Text | References | PDF (16.5 MB) | EPUB | Supplemental
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Article
Angiotensin-converting enzyme 2 inhibits inflammation and apoptosis in high glucose-stimulated microvascular endothelial cell damage by regulating the JAK2/STAT3 signaling pathway
Yi Ren, Wei Xie, Song Yang, Ying Jiang, Danni Wu, Hao Zhang & Shiying Sheng
Pages: 10803-10811
Published online: 27 Apr 2022
AbstractforAngiotensin-converting enzyme 2 inhibits inflammation and apoptosis in high glucose-stimulated microvascular endothelial cell damage by regulating the JAK2/STAT3 signaling pathway | Full Text | References | PDF (5.1 MB) | EPUB
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Article
Livogrit Prevents Methionine-Cystine Deficiency Induced Nonalcoholic Steatohepatitis by Modulation of Steatosis and Oxidative Stress in Human Hepatocyte-Derived Spheroid and in Primary Rat Hepatocytes
Acharya Balkrishna, Vivek Gohel, Priya Kumari, Moumita Manik, Kunal Bhattacharya, Rishabh Dev & Anurag Varshney
Pages: 10811-10826
Published online: 29 Apr 2022
AbstractforLivogrit Prevents Methionine-Cystine Deficiency Induced Nonalcoholic Steatohepatitis by Modulation of Steatosis and Oxidative Stress in Human Hepatocyte-Derived Spheroid and in Primary Rat Hepatocytes | Full Text | References | PDF (7.3 MB) | EPUB
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Article
Colorectal cancer stem cell-derived exosomal long intergenic noncoding RNA 01315 (LINC01315) promotes proliferation, migration, and stemness of colorectal cancer cells
Youran Li, Minna Wu, Shanshan Xu, Hua Huang, Lei Yan & Yunfei Gu
Pages: 10827-10842
Published online: 26 Apr 2022
AbstractforColorectal cancer stem cell-derived exosomal long intergenic noncoding RNA 01315 (LINC01315) promotes proliferation, migration, and stemness of colorectal cancer cells | Full Text | References | PDF (10.8 MB) | EPUB | Supplemental
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Article
Chronic Sigma 1 receptor activation alleviates right ventricular dysfunction secondary to pulmonary arterial hypertension
Yazhou Sun, Weiguo Wan, Xin Zhao, Xueyu Han, Tianxin Ye, Xiaoli Chen, Qian Ran, Xiukun Wang, Xin Liu, Chuan Qu, Shaobo Shi, Cui Zhang & Bo Yang
Pages: 10843-10856
Published online: 27 Apr 2022
AbstractforChronic Sigma 1 receptor activation alleviates right ventricular dysfunction secondary to pulmonary arterial hypertension | Full Text | References | PDF (5.5 MB) | EPUB | Supplemental
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Article
Sufentanil inhibits the proliferation and epithelial mesenchymal transition of lung cancer cells through Wnt/beta-catenin signaling pathway
Minghan Guan, Yifeng Huang & Xiaowen Lin
Pages: 10857-10865
Published online: 27 Apr 2022
AbstractforSufentanil inhibits the proliferation and epithelial mesenchymal transition of lung cancer cells through Wnt/beta-catenin signaling pathway | Full Text | References | PDF (3.8 MB) | EPUB
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Article
Arctiin elevates osteogenic differentiation of MC3T3-E1 cells by modulating cyclin D1
Ziye Liu & Yongsheng Wu
Pages: 10866-10874
Published online: 27 Apr 2022
AbstractforArctiin elevates osteogenic differentiation of MC3T3-E1 cells by modulating cyclin D1 | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
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Article
Increased homocysteine regulated by androgen activates autophagy by suppressing the mammalian target of rapamycin pathway in the granulosa cells of polycystic ovary syndrome mice
Ting Li, Guogang Dong, Yani Kang, Mei Zhang, Xiaoqiang Sheng, Zhilong Wang, Yang Liu, Na Kong & Haixiang Sun
Pages: 10875-10888
Published online: 29 Apr 2022
AbstractforIncreased homocysteine regulated by androgen activates autophagy by suppressing the mammalian target of rapamycin pathway in the granulosa cells of polycystic ovary syndrome mice | Full Text | References | PDF (8.1 MB) | EPUB | Supplemental
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Article
Long noncoding RNA BACE1-antisense transcript plays a critical role in Parkinson’s disease via microRNA-214-3p/Cell death-inducing p53-target protein 1 axis
Lina Li, Hongjuan Wang, Huicang Li, Xin Lu, Yanxiang Gao & Xiaofeng Guo
Pages: 10889-10901
Published online: 28 Apr 2022
AbstractforLong noncoding RNA BACE1-antisense transcript plays a critical role in Parkinson’s disease via microRNA-214-3p/Cell death-inducing p53-target protein 1 axis | Full Text | References | PDF (8.2 MB) | EPUB | Supplemental
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Article
Role of circRNA circ_0000080 in myocardial hypoxia injury
Bo Wang, Yuyang Zhang, Shunmiao Fang & Hui Wang
Pages: 10902-10913
Published online: 27 Apr 2022
AbstractforRole of circRNA circ_0000080 in myocardial hypoxia injury | Full Text | References | PDF (4.3 MB) | EPUB | Supplemental
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Article
Selective bromodomain and extra-terminal bromodomain inhibitor inactivates macrophages and hepatic stellate cells to inhibit liver inflammation and fibrosis
Rong Fu, Shi-Jia Zu, Yan-Jun Liu, Jia-Cheng Li, Wen-Zhen Dang, Li-Ping Liao, Li-Ping Liu, Pan-Yu Chen, He-Ming Huang, Kang-Hui Wu, Bing Zhou, Qin Pan, Cheng Luo, Yuan-Yuan Zhang & Guang-Ming Li
Pages: 10914-10930
Published online: 01 May 2022
AbstractforSelective bromodomain and extra-terminal bromodomain inhibitor inactivates macrophages and hepatic stellate cells to inhibit liver inflammation and fibrosis | Full Text | References | PDF (5.5 MB) | EPUB | Supplemental
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Article
An extraction from Trametes robiniophila Murr. (Huaier) inhibits non-small cell lung cancer proliferation via targeting to epidermal growth factor receptor
Fei Lv, Xiaoqi Li & Ying Wang
Pages: 10931-10943
Published online: 26 Apr 2022
AbstractforAn extraction from Trametes robiniophila Murr. (Huaier) inhibits non-small cell lung cancer proliferation via targeting to epidermal growth factor receptor | Full Text | References | PDF (4.3 MB) | EPUB | Supplemental
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Article
GDC-0941 activates integrin linked kinase (ILK) expression to cause resistance to GDC-0941 in breast cancer by the tumor necrosis factor (TNF)-α signaling pathway
Haifeng Chen, Mingming Cheng, Pengcheng Gao, Xiangzhong Zhang, Ganggang Li, Liting Wang, Long Qin & Hongrui Li
Pages: 10944-10955
Published online: 27 Apr 2022
AbstractforGDC-0941 activates integrin linked kinase (ILK) expression to cause resistance to GDC-0941 in breast cancer by the tumor necrosis factor (TNF)-α signaling pathway | Full Text | References | PDF (12.6 MB) | EPUB | Supplemental
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Article
CCDC106 promotes the proliferation and invasion of ovarian cancer cells by suppressing p21 transcription through a p53-independent pathway
Na Zhao, Chen Wang, Peng Guo, Jun Hou, Hong Yang, Ting Lan, Yehan Zhou, Jiayu Li, Ujjal K. Bhawal & Yang Liu
Pages: 10957-10973
Published online: 29 Apr 2022
AbstractforCCDC106 promotes the proliferation and invasion of ovarian cancer cells by suppressing p21 transcription through a p53-independent pathway | Full Text | References | PDF (6 MB) | EPUB | Supplemental
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Article
Curcumin relieved the rheumatoid arthritis progression via modulating the linc00052/miR-126-5p/PIAS2 axis
Jianwei Xiao, Xu Cai, Weijian Zhou, Rongsheng Wang & Zhizhong Ye
Pages: 10973-10983
Published online: 27 Apr 2022
AbstractforCurcumin relieved the rheumatoid arthritis progression via modulating the linc00052/miR-126-5p/PIAS2 axis | Full Text | References | PDF (7.4 MB) | EPUB
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Article
Euphorbia factor L3 ameliorates rheumatoid arthritis by suppressing the inflammatory response by targeting Rac family small GTPase 1
Haojun Shi, Shufeng Li, Yun Geng, Huancai Fan, Ruojia Zhang, Yuang Zhang, Jihong Pan, Guanhua Song, Luna Ge, Tianhua Xie & Lin Wang
Pages: 10985-10998
Published online: 27 Apr 2022
AbstractforEuphorbia factor L3 ameliorates rheumatoid arthritis by suppressing the inflammatory response by targeting Rac family small GTPase 1 | Full Text | References | PDF (8.4 MB) | EPUB | Supplemental
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Article
Luteolin impacts deoxyribonucleic acid repair by modulating the mitogen-activated protein kinase pathway in colorectal cancer
Yelin Song, Jie Yu, LingLing Li, Lei Wang, Liangle Dong, Guangmin Xi, Yun Jing Lu & Zuowei Li
Pages: 10998-11011
Published online: 27 Apr 2022
AbstractforLuteolin impacts deoxyribonucleic acid repair by modulating the mitogen-activated protein kinase pathway in colorectal cancer | Full Text | References | PDF (6.3 MB) | EPUB | Supplemental
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Article
Circular GOLPH3 RNA exerts oncogenic effects in vitro by regulating the miRNA-1299/LIF axis in oral squamous cell carcinoma
Chen Zou, Xia Li, Haigang Wei, Siyuan Wu, Jing Song, Zhe Tang, Hailing Luo, Xiaozhi Lv & Yilong Ai
Pages: 11012-11025
Published online: 28 Apr 2022
AbstractforCircular GOLPH3 RNA exerts oncogenic effects in vitro by regulating the miRNA-1299/LIF axis in oral squamous cell carcinoma | Full Text | References | PDF (4.8 MB) | EPUB | Supplemental
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Review

Review Article
The role of long non-coding RNA FGD5-AS1 in cancer
Na He, Linbiao Xiang, Lei Chen, Haobin Tong, Keshen Wang, Jie Zhao, Feixue Song, Hanteng Yang, Xinyuan Wei & Zuoyi Jiao
Pages: 11026-11041
Published online: 27 Apr 2022
AbstractforThe role of long non-coding RNA FGD5-AS1 in cancer | Full Text | References | PDF (2.7 MB) | EPUB
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Research Paper

Article
Effects of silencing neuropilin-2 on proliferation, migration, and invasion of colorectal cancer HT-29
Qi-Qi Zhan, Qian-Yu Liu, Xin Yang, Yu-Hui Ge, Lei Xu, Guan-Yi Ding, Shang Guo, Bing Zhu & Wei-Guo Xu
Pages: 11042-11049
Published online: 27 Apr 2022
AbstractforEffects of silencing neuropilin-2 on proliferation, migration, and invasion of colorectal cancer HT-29 | Full Text | References | PDF (4.1 MB) | EPUB
  • 829 Views
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Article
Ultrasound microbubble-mediated RNA interference targeting WNT1 inducible signaling pathway protein 1(WISP1) suppresses the proliferation and metastasis of breast cancer cells
Faying Fang, Weizhi Xu, Jian Zhang, Jin Gu & Gaoyi Yang
Pages: 11050-11060
Published online: 28 Apr 2022
AbstractforUltrasound microbubble-mediated RNA interference targeting WNT1 inducible signaling pathway protein 1(WISP1) suppresses the proliferation and metastasis of breast cancer cells | Full Text | References | PDF (2.7 MB) | EPUB
  • 847 Views
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Article
Translocator protein (18 kDa) regulates the microglial phenotype in Parkinson’s disease through P47
Xue Xue, Rui Duan, Guoyan Zheng, Hucheng Chen, Weiwei Zhang & Liang Shi
Pages: 11062-11072
Published online: 27 Apr 2022
AbstractforTranslocator protein (18 kDa) regulates the microglial phenotype in Parkinson’s disease through P47 | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 1374 Views
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Article
Diosmetin attenuates oxidative stress-induced damage to lens epithelial cells via the mitogen-activated protein kinase (MAPK) pathway
Guanghai Guo & Jin Dong
Pages: 11072-11081
Published online: 28 Apr 2022
AbstractforDiosmetin attenuates oxidative stress-induced damage to lens epithelial cells via the mitogen-activated protein kinase (MAPK) pathway | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
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Article
The long non-coding RNA T cell leukemia homeobox 1 neighbor enhances signal transducer and activator of transcription 5A phosphorylation to promote colon cancer cell invasion, migration, and metastasis
Guanyang Chen, Dongbo Lian, Lei Zhao, Zheng Wang, Qiqige Wuyun & Nengwei Zhang
Pages: 11083-11095
Published online: 03 May 2022
AbstractforThe long non-coding RNA T cell leukemia homeobox 1 neighbor enhances signal transducer and activator of transcription 5A phosphorylation to promote colon cancer cell invasion, migration, and metastasis | Full Text | References | PDF (12.7 MB) | EPUB
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Article
Expression of ATP-binding cassette subfamily B member 1 gene in peripheral blood of patients with acute myocardial infarction
Jianjun Ruan, Heyu Meng, Yanqiu Chen, Zhaohan Yan, Xiangdong Li & Fanbo Meng
Pages: 11095-11105
Published online: 27 Apr 2022
AbstractforExpression of ATP-binding cassette subfamily B member 1 gene in peripheral blood of patients with acute myocardial infarction | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Article
Identification of the metabolic remodeling profile in the early-stage of myocardial ischemia and the contributory role of mitochondrion
Jun He, Qian Liu, Jie Wang, Fangjing Xu, Yucheng Fan, Ruhua He, Ru Yan & Li Zhu
Pages: 11106-11121
Published online: 26 Apr 2022
AbstractforIdentification of the metabolic remodeling profile in the early-stage of myocardial ischemia and the contributory role of mitochondrion | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
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Article
Caffeic acid dimethyl ether alleviates alcohol-induced hepatic steatosis via microRNA-378b-mediated CaMKK2-AMPK pathway
Jun Lu, Yan Zhang, Ying-Zhao Wang, Yuan-Yuan Li, Rui Wang, Yu-Juan Zhong, Li Chen, Meng-Wei Song, Lin Shi, Li Li & Yong-Wen Li
Pages: 11123-11137
Published online: 28 Apr 2022
AbstractforCaffeic acid dimethyl ether alleviates alcohol-induced hepatic steatosis via microRNA-378b-mediated CaMKK2-AMPK pathway | Full Text | References | PDF (4.5 MB) | EPUB | Supplemental
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Article
Long non-coding RNA BBOX1-antisense RNA 1 enhances cell proliferation and migration and suppresses apoptosis in oral squamous cell carcinoma via the miR-3940-3p/laminin subunit gamma 2 axis
Chunguang Zhao, Wei Shi & Min Chen
Pages: 11138-11153
Published online: 04 May 2022
AbstractforLong non-coding RNA BBOX1-antisense RNA 1 enhances cell proliferation and migration and suppresses apoptosis in oral squamous cell carcinoma via the miR-3940-3p/laminin subunit gamma 2 axis | Full Text | References | PDF (8.4 MB) | EPUB
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Article
Long intergenic non-protein coding RNA 00707 regulates chondrocyte apoptosis and proliferation in osteoarthritis by serving as a sponge for microRNA-199-3p
Yan Xu, Liang Duan, Shizhang Liu, Yuanyuan Yang, Zhi Qiao & Liang Shi
Pages: 11137-11145
Published online: 29 Apr 2022
AbstractforLong intergenic non-protein coding RNA 00707 regulates chondrocyte apoptosis and proliferation in osteoarthritis by serving as a sponge for microRNA-199-3p | Full Text | References | PDF (3.7 MB) | EPUB
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Article
Shikonin combined with methotrexate regulate macrophage polarization to treat psoriasis
Tingjun Tao, Yan Chen, Bochen Lai, Jinhua Wang, Weiliang Wang, Weimian Xiao & Xushan Cha
Pages: 11146-11155
Published online: 29 Apr 2022
AbstractforShikonin combined with methotrexate regulate macrophage polarization to treat psoriasis | Full Text | References | PDF (4.2 MB) | EPUB
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Article
Targeting CC chemokine ligand (CCL) 20 by miR-143-5p alleviate lead poisoning-induced renal fibrosis by regulating interstitial fibroblasts excessive proliferation and dysfunction
Lin Han, Yanfang Zou & Chen Yu
Pages: 11156-11168
Published online: 29 Apr 2022
AbstractforTargeting CC chemokine ligand (CCL) 20 by miR-143-5p alleviate lead poisoning-induced renal fibrosis by regulating interstitial fibroblasts excessive proliferation and dysfunction | Full Text | References | PDF (6.8 MB) | EPUB | Supplemental
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Article
Functional deficiency of succinate dehydrogenase promotes tumorigenesis and development of clear cell renal cell carcinoma through weakening of ferroptosis
Jing Yang, Yi Zhou, Yanchun Li, Wanye Hu, Chen Yuan, Shida Chen, Gaoqi Ye, Yuzhou Chen, Yunyi Wu, Jing Liu, Ying Wang, Jing Du & Xiangmin Tong
Pages: 11187-11207
Published online: 05 May 2022
AbstractforFunctional deficiency of succinate dehydrogenase promotes tumorigenesis and development of clear cell renal cell carcinoma through weakening of ferroptosis | Full Text | References | PDF (9.6 MB) | EPUB
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Article
Galangin alleviates rheumatoid arthritis in rats by downregulating the phosphatidylinositol 3-kinase/protein kinase B signaling pathway
Xiongwei Deng, Hailang Le, Taohong Wan, Meizhi Weng & Yongzhen Tan
Pages: 11192-11201
Published online: 29 Apr 2022
AbstractforGalangin alleviates rheumatoid arthritis in rats by downregulating the phosphatidylinositol 3-kinase/protein kinase B signaling pathway | Full Text | References | PDF (5.9 MB) | EPUB
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Article
P75 neurotrophin receptor positively regulates the odontogenic/osteogenic differentiation of ectomesenchymal stem cells via nuclear factor kappa-B signaling pathway
Peifen Shan, Xiaole Wang, Yanyan Zhang, Zhisheng Teng, Yunxiao Zhang, Qiu Jin, Jiefan Liu, Jianfeng Ma & Xin Nie
Pages: 11201-11213
Published online: 29 Apr 2022
AbstractforP75 neurotrophin receptor positively regulates the odontogenic/osteogenic differentiation of ectomesenchymal stem cells via nuclear factor kappa-B signaling pathway | Full Text | References | PDF (5.3 MB) | EPUB | Supplemental
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MEK1/2 inhibitor inhibits neointima formation by activating miR-126-3p/ C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 4 (CXCR4) axis
Yali Yan, Mengmeng Zhu, Jialing Ma, Xiaoyu He, Xiaoxiao Yang, Hongmei Xu, Meixiu Jiang, Shuang Zhang, Yajun Duan, Jihong Han & Yuanli Chen
Pages: 11214-11227
Published online: 29 Apr 2022
AbstractforMEK1/2 inhibitor inhibits neointima formation by activating miR-126-3p/ C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 4 (CXCR4) axis | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
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Article
LncRNA00978 contributes to growth and metastasis of hepatocellular carcinoma cells via mediating microRNA-125b-5p/SOX12 pathway
Zhiqing Cheng, Limei Gong & Qinghe Cai
Pages: 11228-11239
Published online: 29 Apr 2022
AbstractforLncRNA00978 contributes to growth and metastasis of hepatocellular carcinoma cells via mediating microRNA-125b-5p/SOX12 pathway | Full Text | References | PDF (3.2 MB) | EPUB
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Everolimus (RAD001) combined with programmed death-1 (PD-1) blockade enhances radiosensitivity of cervical cancer and programmed death-ligand 1 (PD-L1) expression by blocking the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR)/S6 kinase 1 (S6K1) pathway
Lili Song, Shikai Liu & Sufen Zhao
Pages: 11240-11257
Published online: 29 Apr 2022
AbstractforEverolimus (RAD001) combined with programmed death-1 (PD-1) blockade enhances radiosensitivity of cervical cancer and programmed death-ligand 1 (PD-L1) expression by blocking the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR)/S6 kinase 1 (S6K1) pathway | Full Text | References | PDF (5.8 MB) | EPUB
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Untargeted metabolomics profiling in a mouse model of lung cancer treated with thermal ablation
Haoyue Pang, Kaiwen Hu, Fuyao Li, Hua Duan, Yu Chen, Yaqi Hu, Dan Wang & Min Jiang
Pages: 11258-11268
Published online: 28 Apr 2022
AbstractforUntargeted metabolomics profiling in a mouse model of lung cancer treated with thermal ablation | Full Text | References | PDF (4.8 MB) | EPUB | Supplemental
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Article
Down-regulated HSA_circ_0003528 inhibits hepatocellular carcinoma aggressiveness via the miR-212-3p/XIAP axis
Qi Liu, Xin Xu & Wei Sun
Pages: 11269-11280
Published online: 29 Apr 2022
AbstractforDown-regulated HSA_circ_0003528 inhibits hepatocellular carcinoma aggressiveness via the miR-212-3p/XIAP axis | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
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Downregulated miR-18a and miR-92a synergistically suppress non-small cell lung cancer via targeting Sprouty 4
Xinju Zhang, Xianyi Wang, Binshu Chai, Zong Wu, Xiaomin Liu, Heng Zou, Ziyi Hua, Zhongliang Ma & Weiwei Wang
Pages: 11281-11295
Published online: 29 Apr 2022
AbstractforDownregulated miR-18a and miR-92a synergistically suppress non-small cell lung cancer via targeting Sprouty 4 | Full Text | References | PDF (7.8 MB) | EPUB | Supplemental
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Article
Inhibition of long noncoding RNA cancer susceptibility candidate 7 attenuates hepatocellular carcinoma development by targeting microRNA-30a-5p
Dongsheng Li, Lin Lu, Miaomiao Liu & Jufeng Sun
Pages: 11296-11308
Published online: 29 Apr 2022
AbstractforInhibition of long noncoding RNA cancer susceptibility candidate 7 attenuates hepatocellular carcinoma development by targeting microRNA-30a-5p | Full Text | References | PDF (13 MB) | EPUB | Supplemental
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Article
Overexpression of microRNA-145 enhanced docetaxel sensitivity in breast cancer cells via inactivation of protein kinase B gamma-mediated phosphoinositide 3-kinase -protein kinase B pathway
Ying Zhou, Wei Cai & Hailin Lu
Pages: 11310-11320
Published online: 01 May 2022
AbstractforOverexpression of microRNA-145 enhanced docetaxel sensitivity in breast cancer cells via inactivation of protein kinase B gamma-mediated phosphoinositide 3-kinase -protein kinase B pathway | Full Text | References | PDF (8.5 MB) | EPUB | Supplemental
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Article
GATA binding protein 1 recruits histone deacetylase 2 to the promoter region of nuclear receptor binding protein 2 to affect the tumor microenvironment and malignancy of thyroid carcinoma
Mengyuan Li, Hongwei Jiang, Shengjiang Chen & Yujin Ma
Pages: 11336-11357
Published online: 01 May 2022
AbstractforGATA binding protein 1 recruits histone deacetylase 2 to the promoter region of nuclear receptor binding protein 2 to affect the tumor microenvironment and malignancy of thyroid carcinoma | Full Text | References | PDF (14.2 MB) | EPUB
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